Web Desc
Translational Vaccinology for Global Health
Organizer(s): Christopher L. Karp, Gagandeep Kang and Rino Rappuoli
Date: October 25 - 29, 2016
Location: Park Plaza Riverbank London, London, United Kingdom
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation.
Summary of Meeting:
The time required to launch new global health vaccines is too long and the late failure rate is unsustainably high. Key barriers include insufficient diversity and quality of preclinical concepts and candidates, immunobiological ignorance, and a lack of understanding of correlates or mechanisms of protection. Root causes include siloed science and linear thinking; poor integration across the discovery/development/delivery ecosystem; and slow entry and limited throughput in early human proof of concept testing. This Keystone Symposia meeting aims to bring together those pioneering novel, creative solutions to these problems of global vaccine discovery and development across the academic/biotech/product development partner/pharma spectrum.
Global Health Travel Award Deadline: May 24 2016
Scholarship Deadline: June 27 2016
Discounted Abstract Deadline: June 27 2016
Abstract Deadline: July 26 2016
Discounted Registration Deadline: September 8 2016
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates Foundation
We gratefully acknowledge additional support for this conference from:
Sanofi Pasteur
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline Vaccines
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI126822-01
Funding for this conference was made possible (in part) by 1 R13 AI 126822 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, October 25 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Tuesday, October 25 | 6:30PM - 8:00PM
Social Hour with Lite Bites
Room: Plaza Foyer


Wednesday, October 26 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Wednesday, October 26 | 8:30AM - 11:30AM
Controlled Human Infection Models
Room: Ballroom

Speaker 1 of 7
* Gagandeep Kang, Christian Medical College/Translational Health Science and Technology Institute, India

Wednesday, October 26 | 8:30AM - 11:30AM
Controlled Human Infection Models
Room: Ballroom

Speaker 2 of 7
Robert Sauerwein, Radboud University, Netherlands
Protection and Immune Responses in Malaria after Whole Sporozoite Immunization

Wednesday, October 26 | 8:30AM - 11:30AM
Controlled Human Infection Models
Room: Ballroom

Speaker 3 of 7
Andrew J. Pollard, University of Oxford, UK
Insights into the Biology of Enteric Fever and Typhoid Vaccine Efficacy Using Experimental Human Challenge with Typhoidal Salmonellae

Wednesday, October 26 | 8:30AM - 11:30AM
Controlled Human Infection Models
Room: Ballroom


Coffee Break

Wednesday, October 26 | 8:30AM - 11:30AM
Controlled Human Infection Models
Room: Ballroom

Speaker 5 of 7
Anna P. Durbin, Johns Hopkins Bloomberg School of Public Health, USA
The Dengue Human Infection Model: A Tool to Advance Vaccine Development and the Search for Immune Correlates of Protection


Wednesday, October 26 | 8:30AM - 11:30AM
Controlled Human Infection Models
Room: Ballroom

Speaker 6 of 7
Daniela M. Ferreira, Liverpool School of Tropical Medicine, UK
Short Talk: Controlled Human Co-Infection with Live Attenuated Influenza Vaccine (LAIV) and Pneumococcus

Wednesday, October 26 | 8:30AM - 11:30AM
Controlled Human Infection Models
Room: Ballroom

Speaker 7 of 7
Hedda Wardemann, German Cancer Research Center, Germany
Short Talk: Development and Clonal Evolution of Human Anti-CSP Memory B Cell Antibody Responses

Wednesday, October 26 | 11:45AM - 1:00PM
Transportation to Central Hall Westminster


Wednesday, October 26 | 12:15PM - 1:30PM
Light Lunch
Room: Central Hall Westminster


Wednesday, October 26 | 1:30PM - 3:30PM
Joint Session with Grand Challenges and Keystone Symposia
Room: Central Hall Westminister

UK & Global Innovations to Achieve the Sustainable Development Goals

Emcee: Chris Karp, Bill & Melinda Gates Foundation

Jeremy Farrar, Wellcome Trust

Welcome Address



Spotlight Speaker: Clare Elwell

Biomarkers of Nutrition Related Cognitive Development

Floriane Fidegnon-Edoh, Ursuline Academy




Keynote Conversation: Leadership in Science & Innovation - Good for Britain, Good for the World

Bill Gates, Bill & Melinda Gates Foundation

Opening Remarks

Moderator: Natasha Kaplinsky

Bill Gates, Bill & Melinda Gates Foundation

Minister Priti Patel, Secretary of State for International Development, UK

Sir Richard Branson, Virgin Group



Closing Remarks

Trevor Mundel, Bill & Melinda Gates Foundation

Gayle E. Smith, USAID (Video Address)


Wednesday, October 26 | 3:30PM - 5:00PM
Networking and Welcome Mixer with Grand Challenges and Keyst
one Symposia
Room: QEII Churchill


Wednesday, October 26 | 5:00PM - 5:30PM
Transportation to Park Plaza Riverbank London


Wednesday, October 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Plaza Ballroom


Thursday, October 27 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Thursday, October 27 | 8:30AM - 11:30AM
Human Immune Profiling
Room: Ballroom

Speaker 1 of 7
* Lynda M. Stuart, Bill & Melinda Gates Foundation, USA

Thursday, October 27 | 8:30AM - 11:30AM
Human Immune Profiling
Room: Ballroom

Speaker 2 of 7
Galit Alter, MIT and Harvard University, USA
A Systems Level Approach to Defining Humoral Mechanisms of HIV Control

Thursday, October 27 | 8:30AM - 11:30AM
Human Immune Profiling
Room: Ballroom

Speaker 3 of 7
Mario Roederer, NIAID, National Institutes of Health, USA
Integrating High-Content Technologies for Cellular Analysis

Thursday, October 27 | 8:30AM - 11:30AM
Human Immune Profiling
Room: Ballroom


Coffee Break

Thursday, October 27 | 8:30AM - 11:30AM
Human Immune Profiling
Room: Ballroom

Speaker 5 of 7
Beate Kampmann, London School of Hygiene and Tropical Medicine, UK
Correlates of Protection for Maternal Immunization: A Way Forward?

Thursday, October 27 | 8:30AM - 11:30AM
Human Immune Profiling
Room: Ballroom

Speaker 6 of 7
Leticia Kuri-Cervantes, University of Pennsylvania, USA
Short Talk: Immune Correlates to Butantan-DV/NIH-TV003 Dengue Vaccine

Thursday, October 27 | 8:30AM - 11:30AM
Human Immune Profiling
Room: Ballroom

Speaker 7 of 7
Darragh Duffy, Institut Pasteur, France
Short Talk: Milieu Interieur – Defining the Boundaries of a Healthy Immune Response through Standardized Immunophenotyping

Thursday, October 27 | 11:30AM - 1:30PM
On Own for Lunch


Thursday, October 27 | 11:30AM - 1:00PM
Poster Setup
Room: Plaza Suite


Thursday, October 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Plaza Suite


Thursday, October 27 | 1:30PM - 3:30PM
Workshop 1: Correlates of Protection
Room: Ballroom

Speaker 1 of 5
* Penny M. Heaton, Bill & Melinda Gates Medical Research Institute, USA
Correlates of Protection for Vaccine Discovery and Development

Thursday, October 27 | 1:30PM - 3:30PM
Workshop 1: Correlates of Protection
Room: Ballroom

Speaker 2 of 5
Gemma Moncunill, ISGlobal, Spain
Immune Correlates Associated with RTS,S/AS01E Malaria Vaccination in a Pediatric Phase III Trial in Africa

Thursday, October 27 | 1:30PM - 3:30PM
Workshop 1: Correlates of Protection
Room: Ballroom

Speaker 3 of 5
Raquel Furtado, Albert Einstein College of Medicine, USA
Defining Novel Immune Correlates of Protection in Human Malaria Using Time-of-Flight Cytometry (CyTOF) and Antibody Functional Analyses

Thursday, October 27 | 1:30PM - 3:30PM
Workshop 1: Correlates of Protection
Room: Ballroom

Speaker 4 of 5
Robert Mauro DiFazio, Stanford Medicine, USA
Serial PET-CT Imaging Predicts Vaccine Efficacy Against Tuberculosis in the Non-Human Primate Model

Thursday, October 27 | 1:30PM - 3:30PM
Workshop 1: Correlates of Protection
Room: Ballroom

Speaker 5 of 5
Sophie Rhodes, London School of Hygiene and Tropical Medicine, UK
Use of Mathematical Modelling for Dose Finding in T Cell-Mediated Vaccines

Thursday, October 27 | 3:30PM - 4:00PM
Coffee Available
Room: Ballroom Foyer


Thursday, October 27 | 4:00PM - 6:30PM
Toward PK/PD in B Cell Vaccinology
Room: Ballroom

Speaker 1 of 6
* Chris Wilson, Bill & Melinda Gates Foundation, USA

Thursday, October 27 | 4:00PM - 6:30PM
Toward PK/PD in B Cell Vaccinology
Room: Ballroom

Speaker 2 of 6
Michael G. McHeyzer-Williams, The Scripps Research Institute, USA
Reprogramming B Cell Memory

Thursday, October 27 | 4:00PM - 6:30PM
Toward PK/PD in B Cell Vaccinology
Room: Ballroom

Speaker 3 of 6
Arup K. Chakraborty, Massachusetts Institute of Technology, USA
Modeling Selection Forces during Antibody Affinity Maturation

Thursday, October 27 | 4:00PM - 6:30PM
Toward PK/PD in B Cell Vaccinology
Room: Ballroom

Speaker 4 of 6
William Ballou, GlaxoSmithKline, USA
Optimizing Somatic Hypermutation? An Intriguing Observation from the Clinic

Thursday, October 27 | 4:00PM - 6:30PM
Toward PK/PD in B Cell Vaccinology
Room: Ballroom

Speaker 5 of 6
John T. Schiller, NCI, National Institutes of Health, USA
HPV VLP Vaccines: Asymtoting to a Single Dose?

Thursday, October 27 | 4:00PM - 6:30PM
Toward PK/PD in B Cell Vaccinology
Room: Ballroom

Speaker 6 of 6
Monia Bardelli, GlaxoSmithKline, Italy
Short Talk: Profiling the Molecular Mechanisms that Drive the Fate of Human B Cells in Response to Vaccination

Thursday, October 27 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: Plaza Suite
No registration fees are used to fund alcohol served at this function.

Thursday, October 27 | 7:00PM - 10:00PM
Poster Session 1
Room: Plaza Suite


Friday, October 28 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Friday, October 28 | 8:30AM - 11:30AM
T Cells
Room: Ballroom

Speaker 1 of 7
* Karen S. Anderson, Arizona State University, USA

Friday, October 28 | 8:30AM - 11:30AM
T Cells
Room: Ballroom

Speaker 2 of 7
Louis J. Picker, Oregon Health & Science University, USA
Cytomegalovirus Vectors: Exploiting Viral Control of the CD8+ T Cell Epitope Targeting

Friday, October 28 | 8:30AM - 11:30AM
T Cells
Room: Ballroom

Speaker 3 of 7
Bette Tina Marie Korber, Los Alamos National Laboratory, USA
Epigraph Vaccine Designs for Variable Pathogens

Friday, October 28 | 8:30AM - 11:30AM
T Cells
Room: Ballroom


Coffee Break

Friday, October 28 | 8:30AM - 11:30AM
T Cells
Room: Ballroom

Speaker 5 of 7
D. Branch Moody, Brigham and Women's Hospital, USA
Beyond the MHC: Activation of T Cells by CD1 and M. tuberculosis Lipids

Friday, October 28 | 8:30AM - 11:30AM
T Cells
Room: Ballroom

Speaker 6 of 7
Andrew J. McMichael, Oxford University, UK
HLA-E-Restricted CD8 T Cells

Friday, October 28 | 8:30AM - 11:30AM
T Cells
Room: Ballroom

Speaker 7 of 7
Denise L. Doolan, James Cook University, Australia
Short Talk: Rational Vaccine Design against Complex Pathogens using Genomic Sequence

Friday, October 28 | 11:30AM - 5:00PM
On Own for Lunch


Friday, October 28 | 11:30AM - 1:00PM
Poster Setup
Room: Plaza Suite


Friday, October 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Plaza Suite


Friday, October 28 | 1:30PM - 3:30PM
Workshop 2: Human Immunophenotyping
Room: Ballroom

Speaker 1 of 7
* Mark M. Davis, Stanford University School of Medicine, USA
Systems Immunology and Vaccine Development

Friday, October 28 | 1:30PM - 3:30PM
Workshop 2: Human Immunophenotyping
Room: Ballroom

Speaker 2 of 7
Margherita Coccia, GlaxoSmithKline Vaccines, Belgium
Mass Cytometry Analysis of a Mosquirix™ Controlled Human Malaria Challenge Trial: A Multivariate Approach

Friday, October 28 | 1:30PM - 3:30PM
Workshop 2: Human Immunophenotyping
Room: Ballroom

Speaker 3 of 7
Christine Dahlke, University Medical Center Hamburg-Eppendorf, Germany
The rVSV-Vaccine Platform: Comprehensive Analysis of Immunogenicity against Vector and Insert following rVSV-Vectored Ebola Vaccination

Friday, October 28 | 1:30PM - 3:30PM
Workshop 2: Human Immunophenotyping
Room: Ballroom

Speaker 4 of 7
Tracey Day, Infectious Disease Research Institute, USA
First-in-Human Evaluation of Safety and Immunogenicity of the Tetravalent Mycobacterium tuberculosis Vaccine, ID93+GLA-SE

Friday, October 28 | 1:30PM - 3:30PM
Workshop 2: Human Immunophenotyping
Room: Ballroom

Speaker 5 of 7
Florian Rubelt, Stanford University, USA
Distinctive Differences in B and T Cell Receptor Repertoire and Cell Frequencies Are Evident in Individual Immune Responses

Friday, October 28 | 1:30PM - 3:30PM
Workshop 2: Human Immunophenotyping
Room: Ballroom

Speaker 6 of 7
Eita Sasaki, National Institute of Infectious Disease, Japan
Establishment of a Novel Safety Evaluating System for Vaccines and Adjuvants Using the Genes Expression Profile and Statistical Model

Friday, October 28 | 1:30PM - 3:30PM
Workshop 2: Human Immunophenotyping
Room: Ballroom

Speaker 7 of 7
Gianna Triller, German Cancer Research Center, Germany
Single-Cell Analysis of Rare Memory B Cell Antibodies to Natural Human Malaria Infection

Friday, October 28 | 3:30PM - 4:00PM
Coffee Available
Room: Ballroom Foyer


Friday, October 28 | 4:00PM - 6:45PM
Novel Approaches to Antigen Identification and Immunogen Des
ign

Room: Ballroom

Speaker 1 of 7
* Rino Rappuoli, GlaxoSmithKline Vaccines, Italy

Friday, October 28 | 4:00PM - 6:45PM
Novel Approaches to Antigen Identification and Immunogen Des
ign

Room: Ballroom

Speaker 2 of 7
Ashley J. Birkett, PATH, USA
Development of Vaccines for Malaria Parasite Elimination and Eradication: The Role of Monoclonal Antibodies in Accelerating Development

Friday, October 28 | 4:00PM - 6:45PM
Novel Approaches to Antigen Identification and Immunogen Des
ign

Room: Ballroom

Speaker 3 of 7
Peter D. Kwong, NIAID, National Institutes of Health, USA
Structure-Based Design of Fusion-Glycoprotein Vaccines for Paramyxoviruses

Friday, October 28 | 4:00PM - 6:45PM
Novel Approaches to Antigen Identification and Immunogen Des
ign

Room: Ballroom

Speaker 4 of 7
Louis Schofield, James Cook University, Australia
Carbohydrate-Based Vaccines for Malaria

Friday, October 28 | 4:00PM - 6:45PM
Novel Approaches to Antigen Identification and Immunogen Des
ign

Room: Ballroom

Speaker 5 of 7
Florian Krammer, Icahn School of Medicine at Mount Sinai, USA
Towards a Universal Influenza Virus Vaccine

Friday, October 28 | 4:00PM - 6:45PM
Novel Approaches to Antigen Identification and Immunogen Des
ign

Room: Ballroom

Speaker 6 of 7
Masaru Kanekiyo, NIAID, National Institutes of Health, USA
Short Talk: Vaccine-Induced Broad and Potent Influenza H1N1 Neutralizing Antibody Targets a Novel Viral Site of Vulnerability in the Hemagglutinin Head Domain

Friday, October 28 | 4:00PM - 6:45PM
Novel Approaches to Antigen Identification and Immunogen Des
ign

Room: Ballroom

Speaker 7 of 7
Kizzmekia S. Corbett, NIAID, National Institutes of Health, USA
Short Talk: Immunogenicity of MERS Coronavirus Spike Trimer Vaccine

Friday, October 28 | 6:45PM - 7:45PM
Social Hour with Lite Bites
Room: Plaza Suite
No registration fees are used to fund alcohol served at this function.

Friday, October 28 | 7:00PM - 10:00PM
Poster Session 2
Room: Plaza Suite


Saturday, October 29 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Saturday, October 29 | 8:30AM - 11:30AM
Adjuvants, Mucosal and Otherwise
Room: Ballroom

Speaker 1 of 7
* Anna P. Durbin, Johns Hopkins Bloomberg School of Public Health, USA

Saturday, October 29 | 8:30AM - 11:30AM
Adjuvants, Mucosal and Otherwise
Room: Ballroom

Speaker 2 of 7
Gagandeep Kang, Christian Medical College/Translational Health Science and Technology Institute, India
Mucosal Barriers to Oral Vaccination in Developing Countries

Saturday, October 29 | 8:30AM - 11:30AM
Adjuvants, Mucosal and Otherwise
Room: Ballroom

Speaker 3 of 7
Ulrich H. Von Andrian, Harvard Medical School, USA
Induction of Mucosal Immune Responses

Saturday, October 29 | 8:30AM - 11:30AM
Adjuvants, Mucosal and Otherwise
Room: Ballroom


Coffee Break

Saturday, October 29 | 8:30AM - 11:30AM
Adjuvants, Mucosal and Otherwise
Room: Ballroom

Speaker 5 of 7
Arnaud Marchant, Université libre de Bruxelles, Belgium
Impact of Adjuvants on the Functional Program of Vaccine-Induced T Lymphocytes

Saturday, October 29 | 8:30AM - 11:30AM
Adjuvants, Mucosal and Otherwise
Room: Ballroom

Speaker 6 of 7
Aideen C. Allen, Institut de Pharmacologie et de Biologie Structurale, France
Short Talk: Exploiting Synergy between STING and TLR Agonists as Adjuvants for a Pertussis Vaccine

Saturday, October 29 | 8:30AM - 11:30AM
Adjuvants, Mucosal and Otherwise
Room: Ballroom

Speaker 7 of 7
Wivine Burny, GlaxoSmithKline, Belgium
Short Talk: Early Responses to Adjuvanted Vaccination in Humans: Relationships with Adaptive Responses

Saturday, October 29 | 11:30AM - 1:30PM
On Own for Lunch


Saturday, October 29 | 1:30PM - 3:30PM
Clinical Trial Readouts
Room: Ballroom

Speaker 1 of 5
* William Ballou, GlaxoSmithKline, USA

Saturday, October 29 | 1:30PM - 3:30PM
Clinical Trial Readouts
Room: Ballroom

Speaker 2 of 5
Carolyn E. Clark, Norwegian Institute of Public Health, Norway
The rVSV-Vectored Ebola Vaccine: Fast-tracked Clinical Testing during the 2014-15 Epidemic

Saturday, October 29 | 1:30PM - 3:30PM
Clinical Trial Readouts
Room: Ballroom

Speaker 3 of 5
Thomas Heineman, GlaxoSmithKline Vaccines, USA
Herpes Zoster Subunit Vaccine - Overcoming Immunosenescence in the Elderly

Saturday, October 29 | 1:30PM - 3:30PM
Clinical Trial Readouts
Room: Ballroom

Speaker 4 of 5
Neil Ferguson, Imperial College London, UK
Modelling the Efficacy Profile of the Sanofi Dengue Vaccine: Implications for Use

Saturday, October 29 | 1:30PM - 3:30PM
Clinical Trial Readouts
Room: Ballroom

Speaker 5 of 5
Leo Swadling, University of Oxford, UK
Short Talk: Potent Virally Vectored T-Cell Vaccines Fail to Reconstitute an Effective HCV-Specific T-Cell Response during Chronic Infection

Saturday, October 29 | 3:30PM - 4:00PM
Coffee Available
Room: Ballroom Foyer


Saturday, October 29 | 4:00PM - 5:45PM
Accelerating Global Health Vaccine R&D
Room: Ballroom

Speaker 1 of 4
* Christopher L. Karp, Bill & Melinda Gates Foundation, USA

Saturday, October 29 | 4:00PM - 5:45PM
Accelerating Global Health Vaccine R&D
Room: Ballroom

Speaker 2 of 4
Rino Rappuoli, GlaxoSmithKline Vaccines, Italy
Reverse Vaccinology 2.0: Human Immunology Instructs Vaccine Antigen Design

Saturday, October 29 | 4:00PM - 5:45PM
Accelerating Global Health Vaccine R&D
Room: Ballroom

Speaker 3 of 4
Karen S. Anderson, Arizona State University, USA
Frontiers of T Cell Epitope Prediction/Discovery for Cancer Vaccines

Saturday, October 29 | 4:00PM - 5:45PM
Accelerating Global Health Vaccine R&D
Room: Ballroom

Speaker 4 of 4
Rafi Ahmed, Emory University School of Medicine, USA
Antibody Repertoires in Vaccinated Populations

Saturday, October 29 | 5:45PM - 6:30PM
Closing Keynote Address
Room: Ballroom

Speaker 1 of 1
Chris Wilson, Bill & Melinda Gates Foundation, USA
Collaboration Across Traditional Boundaries to Accelerate Global Health Vaccine R&D

Saturday, October 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Plaza Suite
No registration fees are used to fund alcohol served at this function.

Saturday, October 29 | 8:00PM - 11:00PM
Entertainment
Room: Plaza Suite
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Saturday, October 29 | 8:00PM - 11:00PM
Cash Bar
Room: Plaza Suite


Sunday, October 30 | 10:25AM - 10:25AM
Departure


*Session Chair.