Web Desc
Adaptations to Hypoxia in Physiology and Disease
joint with Tumor Metabolism: Mechanisms and Targets
Organizer(s): M. Celeste Simon, Amato J. Giaccia and Randall S. Johnson
Date: March 05 - 09, 2017
Location: Whistler Conference Centre, Whistler, BC, Canada
Sponsored by Takeda Pharmaceutical Company Limited
For important information on the coronavirus, please click here
Summary of Meeting:
Cellular responses to changes in oxygen availability have important implications for both physiology and pathophysiology, in particular in the setting of solid tumor progression. A number of hypoxia-inducible pathways have been characterized, such as the large transcriptome regulated by hypoxia-inducible factors (HIFs). However, many other oxygen-sensing pathways exist within the cell. The aim of this meeting is to disseminate up-to-date information on basic mechanisms of cellular and tissue hypoxia responses, and discuss the impact of these responses on physiology and cancer, with an emphasis on HIF-independent, but nevertheless fundamental, oxygen-sensing pathways. Outcomes of this meeting will include the dissemination of new scientific knowledge, the discussion of new methodologies, the education of graduate students and postdoctoral fellows in this discipline, and promotion of new collaborations between clinicians, basic researchers and industrial partners. This will be the eighth Keystone Symposia meeting on Hypoxia, which brings together academic, clinical and industrial researchers to enhance synergy between these groups and develop translational strategies for targeting hypoxic stress responses for therapeutic benefit.
Scholarship Deadline: November 8 2016
Discounted Abstract Deadline: November 8 2016
Abstract Deadline: December 8 2016
Discounted Registration Deadline: January 12 2017
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Takeda Pharmaceutical Company Limited
We gratefully acknowledge additional support for this conference from:
Baker RuskinnHypOxygenXcell Biosciences
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Peloton Therapeutics
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 05 | 4:00PM - 8:00PM
Arrival and Registration
Room: Grand Foyer


Sunday, March 05 | 6:00PM - 8:00PM
Welcome Mixer
Room: Grand Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Monday, March 06 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Sea to Sky B/C

Speaker 1 of 2
* M. Celeste Simon, University of Pennsylvania, USA

Monday, March 06 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Sea to Sky B/C

Speaker 2 of 2
Chi Van Dang, University of Pennsylvania, USA
MYC as the Master Regulator of Proliferative Metabolism

Monday, March 06 | 9:00AM - 11:30AM
Hypoxia and Tumor Metabolism (Joint)
Room: Sea to Sky B/C

Speaker 1 of 7
* Amato J. Giaccia, Stanford University, USA

Monday, March 06 | 9:00AM - 11:30AM
Hypoxia and Tumor Metabolism (Joint)
Room: Sea to Sky B/C

Speaker 2 of 7
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
2-Oxoglutarate-Dependent Dioxygenases and Cancer

Monday, March 06 | 9:00AM - 11:30AM
Hypoxia and Tumor Metabolism (Joint)
Room: Sea to Sky B/C


Coffee Break

Monday, March 06 | 9:00AM - 11:30AM
Hypoxia and Tumor Metabolism (Joint)
Room: Sea to Sky B/C

Speaker 4 of 7
Nicholas Denko, Ohio State University, USA
Hypoxic Regulation of Mitochondrial Function

Monday, March 06 | 9:00AM - 11:30AM
Hypoxia and Tumor Metabolism (Joint)
Room: Sea to Sky B/C

Speaker 5 of 7
Andrew M. Intlekofer, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Acidification Enhances Production of L-2-Hydroxyglutarate through Alternative Substrate use by Dehydrogenase Enzymes

Monday, March 06 | 9:00AM - 11:30AM
Hypoxia and Tumor Metabolism (Joint)
Room: Sea to Sky B/C

Speaker 6 of 7
James A. Nathan, Cambridge Institute for Medical Research, UK
Short Talk: Oxygen Sensing and Metabolism: The Role of the 2-Oxoglutarate Dehydrogenase Complex and Mitochondrial Protein Lipoylation

Monday, March 06 | 9:00AM - 11:30AM
Hypoxia and Tumor Metabolism (Joint)
Room: Sea to Sky B/C

Speaker 7 of 7
Karen H. Vousden, Francis Crick Institute, UK
A Role for p53 in the Adaptation to Metabolic Stress

Monday, March 06 | 11:15AM - 5:00PM
On Own for Lunch


Monday, March 06 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Monday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Monday, March 06 | 2:30PM - 4:30PM
Workshop 1
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 1 of 9
* Costas A. Lyssiotis, University of Michigan, USA


Monday, March 06 | 2:30PM - 4:30PM
Workshop 1
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 2 of 9
Sumin Kang, Emory University, USA
Phosphorylation-Mediated Activation of Lactate Dehydrogenase A Promotes Cancer Cell Invasion and Tumor Metastasis


Monday, March 06 | 2:30PM - 4:30PM
Workshop 1
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 3 of 9
Issam Ben-Sahra, Northwestern University, USA
Nucleotide Sensing by the mTORC1 Signaling Network


Monday, March 06 | 2:30PM - 4:30PM
Workshop 1
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 4 of 9
Atsuo T. Sasaki, University of Cincinnati, USA
SSK2 Couples Nucleolar Transcription and Anabolic GTP Metabolism for Gliomagenesis


Monday, March 06 | 2:30PM - 4:30PM
Workshop 1
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 5 of 9
Isaac Spencer Harris, University of Rochester, USA
Understanding the Vulnerabilities in Cancer Cells Upon Inhibition of Glutathione Synthesis


Monday, March 06 | 2:30PM - 4:30PM
Workshop 1
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 6 of 9
Won Dong Lee, Princeton University, USA
Inferring Compartmentalized Mitochondrial, Nuclear, and Cytosolic Metabolic Fluxes via Isotope Tracing with Cell Fractionation


Monday, March 06 | 2:30PM - 4:30PM
Workshop 1
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 7 of 9
Lauren E. Drake, University of Chicago, USA
BNip3 Loss Promotes Hepatocellular Carcinoma Growth through Increased Lipogenesis


Monday, March 06 | 2:30PM - 4:30PM
Workshop 1
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 8 of 9
Salvador Aznar Benitah, ICREA and Institute for Research in Biomedicine, Spain
Identifying and Targeting Metastatic-Initiating Cells through the Fatty Acid Receptor CD36


Monday, March 06 | 2:30PM - 4:30PM
Workshop 1
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 9 of 9
Jing Chen, Winship Cancer Institute, Emory University, USA
Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth


Monday, March 06 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Monday, March 06 | 5:00PM - 7:00PM
Hypoxic Influences on Intracellular and Tissue Homeostasis
Room: Sea to Sky B

Speaker 1 of 5
* Richard K. Bruick, University of Texas Southwestern Medical Center, USA

Monday, March 06 | 5:00PM - 7:00PM
Hypoxic Influences on Intracellular and Tissue Homeostasis
Room: Sea to Sky B

Speaker 2 of 5
Young Il Yeom, Korea Research Institute of Bioscience and Biotechnology, South Korea
Lactate-Induced Responses to Hypoxia

Monday, March 06 | 5:00PM - 7:00PM
Hypoxic Influences on Intracellular and Tissue Homeostasis
Room: Sea to Sky B

Speaker 3 of 5
Geert Carmeliet, KU Leuven, Belgium
Glutamine, Glycogen and Bioenergetics

Monday, March 06 | 5:00PM - 7:00PM
Hypoxic Influences on Intracellular and Tissue Homeostasis
Room: Sea to Sky B

Speaker 4 of 5
Othon Iliopoulos, Massachusetts General Hospital Cancer Center, USA
Glutaminase and PARP Inhibitors Synergistically Suppress ROS and Pyrimidine Dependent Growth of VHL-Deficient Renal Cell Cancer: A Novel Strategy for Treatment of Hypoxia-Driven and HIF-Expressing Tumors

Monday, March 06 | 5:00PM - 7:00PM
Hypoxic Influences on Intracellular and Tissue Homeostasis
Room: Sea to Sky B

Speaker 5 of 5
Thomas Markus Leissing, University of Oxford, UK
Short Talk: Structural Basis for the Inhibition of Prolyl-Hydroxylase Domain Containing Proteins (PHDs) by Clinical Candidates for Anaemia Treatment

Monday, March 06 | 5:00PM - 7:00PM
Oncogenic Control of Metabolism
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 1 of 5
* Heather Christofk, University of California, Los Angeles, USA


Monday, March 06 | 5:00PM - 7:00PM
Oncogenic Control of Metabolism
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 2 of 5
Lewis C. Cantley, Weill Cornell Medicine, USA
PI3K Signaling and Glucose Metabolism in Tumors


Monday, March 06 | 5:00PM - 7:00PM
Oncogenic Control of Metabolism
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 3 of 5
Almut Schulze, University of Würzburg/Theodor-Boveri Institute, Germany
Targeting Glucose and Lipid Metabolism in Cancer


Monday, March 06 | 5:00PM - 7:00PM
Oncogenic Control of Metabolism
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 4 of 5
Brendan D. Manning, Harvard School of Public Health, USA
A Coordinated Anabolic Program Downstream of mTOR


Monday, March 06 | 5:00PM - 7:00PM
Oncogenic Control of Metabolism
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 5 of 5
Alejo Efeyan, Spanish National Cancer Research Institute, Spain
Short Talk: Oncogenic Mutations in the Nutrient Sensing Pathway Upstream of mTORC1 Alter B Lymphocyte Functions in Novel Genetically-engineered Mice


Monday, March 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Monday, March 06 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A


Tuesday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Tuesday, March 07 | 8:00AM - 11:15AM
Physiological Responses to Hypoxia
Room: Sea to Sky B

Speaker 1 of 8
* Maria F. Czyzyk-Krzeska, University of Cincinnati, USA

Tuesday, March 07 | 8:00AM - 11:15AM
Physiological Responses to Hypoxia
Room: Sea to Sky B

Speaker 2 of 8
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Metabolic Adaptations of Tumor Blood Vessels

Tuesday, March 07 | 8:00AM - 11:15AM
Physiological Responses to Hypoxia
Room: Sea to Sky B

Speaker 3 of 8
Frank S. Lee, University of Pennsylvania School of Medicine, USA
Short Talk: Studies on the Zinc Finger of Prolyl Hydroxylase Domain Protein 2 (PHD2), a Hypoxia Inducible Factor-alpha Hydroxylase

Tuesday, March 07 | 8:00AM - 11:15AM
Physiological Responses to Hypoxia
Room: Sea to Sky B

Speaker 4 of 8
Francisco J. Quintana, Harvard Medical School, USA
Regulation of CNS Inflammation by Hypoxia-Responsive Signaling

Tuesday, March 07 | 8:00AM - 11:15AM
Physiological Responses to Hypoxia
Room: Sea to Sky B


Coffee Break

Tuesday, March 07 | 8:00AM - 11:15AM
Physiological Responses to Hypoxia
Room: Sea to Sky B

Speaker 6 of 8
Mark R. Boothby, Vanderbilt University Medical Center, USA
Short Talk: Germinal Center Hypoxia and Regulation of mTORC1 Activity in B Cells Shape Antibody Response Qualities

Tuesday, March 07 | 8:00AM - 11:15AM
Physiological Responses to Hypoxia
Room: Sea to Sky B

Speaker 7 of 8
Janine T. Erler, University of Copenhagen, Denmark
Hypoxia-Driven ECM Remodelling during Cancer Progression

Tuesday, March 07 | 8:00AM - 11:15AM
Physiological Responses to Hypoxia
Room: Sea to Sky B

Speaker 8 of 8
Navdeep S. Chandel, Northwestern University, USA
Why Mammalian Cells Respire?

Tuesday, March 07 | 8:00AM - 11:15AM
Metabolic Strategies in Cancer
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 1 of 8
* Jared Rutter, University of Utah, USA


Tuesday, March 07 | 8:00AM - 11:15AM
Metabolic Strategies in Cancer
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 2 of 8
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Metabolic Adaptations to Allow Tumor Cell Proliferation


Tuesday, March 07 | 8:00AM - 11:15AM
Metabolic Strategies in Cancer
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 3 of 8
Jurre J. Kamphorst, Rheos Medicines, USA
Triglycerides Buffer Membrane Phospholipid Saturation during Hypoxic Stress


Tuesday, March 07 | 8:00AM - 11:15AM
Metabolic Strategies in Cancer
This session is from Tumor Metabolism
Room: Sea to Sky C


Coffee Break


Tuesday, March 07 | 8:00AM - 11:15AM
Metabolic Strategies in Cancer
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 5 of 8
Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Heterogeneous Metabolic Phenotypes and Liabilities in Human Cancer


Tuesday, March 07 | 8:00AM - 11:15AM
Metabolic Strategies in Cancer
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 6 of 8
Sarah-Maria Fendt, VIB Leuven, Belgium
Cancer Metabolism during Metastasis Formation


Tuesday, March 07 | 8:00AM - 11:15AM
Metabolic Strategies in Cancer
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 7 of 8
Cosimo Commisso, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Not Dying of Starvation: Nutrient Stress Controls Macropinocytosis in Tumor Cells


Tuesday, March 07 | 8:00AM - 11:15AM
Metabolic Strategies in Cancer
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 8 of 8
Elizabeth Petri Henske, Brigham and Women's Hospital, USA
Short Talk: Therapeutic Targeting of mTORC1-Dependent Metabolic Vulnerabilities in TSC and LAM


Tuesday, March 07 | 11:15AM - 2:30PM
On Own for Lunch


Tuesday, March 07 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Tuesday, March 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1: Fundamental Processes of Oxygen Sensing
Room: Sea to Sky B

Speaker 1 of 7
James A. Smythies, University of Oxford, UK
Utilisation of Next Generation Sequencing Technologies to Identify Novel Contributors to Hypoxia Inducible Factor Binding Site Selectivity

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1: Fundamental Processes of Oxygen Sensing
Room: Sea to Sky B

Speaker 2 of 7
* Luis del Peso, Universidad Autonoma, Spain
Transcriptional Repression in Hypoxia is Mediated by the Sin3A Histone Deacetylase Complex

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1: Fundamental Processes of Oxygen Sensing
Room: Sea to Sky B

Speaker 3 of 7
Johannes Schödel, Universitätsklinikum Erlangen, Germany
Complex Regulation of Glucose Transporter 3 Expression by HIF

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1: Fundamental Processes of Oxygen Sensing
Room: Sea to Sky B

Speaker 4 of 7
Andrew Fraser, University of Toronto, Canada
How Worms Hold Their Breath: The Unusual Metabolic Response of Nematodes to Hypoxia and the Importance for 2 Billion Humans

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1: Fundamental Processes of Oxygen Sensing
Room: Sea to Sky B

Speaker 5 of 7
Roman Vozdek, University of California, San Francisco, USA
Novel Uncharacterized Protein Tyrosine Kinase Senses Hypoxia to Mediate HIF-1 Independent Transcriptional Response in C. elegans

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1: Fundamental Processes of Oxygen Sensing
Room: Sea to Sky B

Speaker 6 of 7
Austin Gabel, University of Maryland, Baltimore County, USA
Understanding Induction of Suspended Animation In Zebrafish

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1: Fundamental Processes of Oxygen Sensing
Room: Sea to Sky B

Speaker 7 of 7
Farhad B. Imam, Bill & Melinda Gates Foundation, USA
Cellular and Metabolic Studies of Hypoxia-Sensitive Mutants in irs2 and ctrc3, Key Regulators of Glucose and Fatty Acid Metabolism

Tuesday, March 07 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Tuesday, March 07 | 5:00PM - 7:00PM
Metabolic Adaptations of Cells within the Tumor Microenviron
ment (Joint)

Room: Sea to Sky B/C

Speaker 1 of 5
* Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany

Tuesday, March 07 | 5:00PM - 7:00PM
Metabolic Adaptations of Cells within the Tumor Microenviron
ment (Joint)

Room: Sea to Sky B/C

Speaker 2 of 5
Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
The Functional Contribution of Exosomes in Cancer Metabolism and Metastasis

Tuesday, March 07 | 5:00PM - 7:00PM
Metabolic Adaptations of Cells within the Tumor Microenviron
ment (Joint)

Room: Sea to Sky B/C

Speaker 3 of 5
Randall S. Johnson, University of Cambridge, UK
The Metabolic Role of Hypoxic Response in T Cell Activation

Tuesday, March 07 | 5:00PM - 7:00PM
Metabolic Adaptations of Cells within the Tumor Microenviron
ment (Joint)

Room: Sea to Sky B/C

Speaker 4 of 5
Shannon J. Turley, Genentech, Inc., USA
Leukocyte Function and Positioning in Diverse Stromal Niches

Tuesday, March 07 | 5:00PM - 7:00PM
Metabolic Adaptations of Cells within the Tumor Microenviron
ment (Joint)

Room: Sea to Sky B/C

Speaker 5 of 5
Hong Xie, University of Pennsylvania, USA
Short Talk: Balancing Anabolic Metabolism with Homeostatic Stress Responses in Myc-Transformed Cancer Cells

Tuesday, March 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Tuesday, March 07 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Wednesday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Wednesday, March 08 | 8:00AM - 11:15AM
Biochemical and Epigenetic Responses to Hypoxia
Room: Sea to Sky B

Speaker 1 of 8
* Frank S. Lee, University of Pennsylvania School of Medicine, USA

Wednesday, March 08 | 8:00AM - 11:15AM
Biochemical and Epigenetic Responses to Hypoxia
Room: Sea to Sky B

Speaker 2 of 8
Peter J. Ratcliffe, University of Oxford, UK
Genome Wide Studies of the Hypoxia Transcriptome

Wednesday, March 08 | 8:00AM - 11:15AM
Biochemical and Epigenetic Responses to Hypoxia
Room: Sea to Sky B

Speaker 3 of 8
Daniel Cooper, Duke University School of Medicine, USA
Short Talk: Hypoxia and Radiation Regulate HIF1alpha Gene Targets in a Context-Dependent manner

Wednesday, March 08 | 8:00AM - 11:15AM
Biochemical and Epigenetic Responses to Hypoxia
Room: Sea to Sky B

Speaker 4 of 8
Fraydoon Rastinejad, University of Oxford, UK
Structures and Drug-Binding Potentials of HIF-alpha-ARNT Heterodimers

Wednesday, March 08 | 8:00AM - 11:15AM
Biochemical and Epigenetic Responses to Hypoxia
Room: Sea to Sky B


Coffee Break

Wednesday, March 08 | 8:00AM - 11:15AM
Biochemical and Epigenetic Responses to Hypoxia
Room: Sea to Sky B

Speaker 6 of 8
Isha Jain, Massachusetts General Hospital, USA
Short Talk: Hypoxia as a Therapy for Mitochondrial Disease

Wednesday, March 08 | 8:00AM - 11:15AM
Biochemical and Epigenetic Responses to Hypoxia
Room: Sea to Sky B

Speaker 7 of 8
Eli M. Wallace, Merck, USA
Small Molecule HIF-2a Antagonists and Their Therapeutic Applications


Wednesday, March 08 | 8:00AM - 11:15AM
Biochemical and Epigenetic Responses to Hypoxia
Room: Sea to Sky B

Speaker 8 of 8
Maria F. Czyzyk-Krzeska, University of Cincinnati, USA
Oncogenic and Tumor Suppressive Autophagic Programs in Renal Cell Carcinoma

Wednesday, March 08 | 8:00AM - 11:15AM
Metabolism, Signaling and Epigenetics
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 1 of 8
* Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA


Wednesday, March 08 | 8:00AM - 11:15AM
Metabolism, Signaling and Epigenetics
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 2 of 8
Aimee L. Edinger, University of California, Irvine, USA
Macropinocytosis Drives Cancer Cell Growth in Both Nutrient-Limiting and-Replete Conditions


Wednesday, March 08 | 8:00AM - 11:15AM
Metabolism, Signaling and Epigenetics
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 3 of 8
Jason Locasale, Duke University School of Medicine, USA
Diet, Cancer, and Epigenetics


Wednesday, March 08 | 8:00AM - 11:15AM
Metabolism, Signaling and Epigenetics
This session is from Tumor Metabolism
Room: Sea to Sky C


Coffee Break


Wednesday, March 08 | 8:00AM - 11:15AM
Metabolism, Signaling and Epigenetics
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 5 of 8
Joshua D. Rabinowitz, Princeton University, USA
Multiple Functions of Mitochondrial Folate Metabolism


Wednesday, March 08 | 8:00AM - 11:15AM
Metabolism, Signaling and Epigenetics
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 6 of 8
Kathryn E. Wellen, University of Pennsylvania, USA
Acetyl-CoA at the Crossroads of Metabolism and Epigenetics


Wednesday, March 08 | 8:00AM - 11:15AM
Metabolism, Signaling and Epigenetics
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 7 of 8
Christian C. Dibble, Beth Israel Deaconess Medical Center, USA
Short Talk: PI3K Signaling Controls de novo Biosynthesis of Coenzyme A from Vitamin B5


Wednesday, March 08 | 8:00AM - 11:15AM
Metabolism, Signaling and Epigenetics
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 8 of 8
Jordan Meier, NCI, National Institutes of Health, USA
Short Talk: Defining Metabolic Mechanisms of Epigenetic Signaling using Chemoproteomics


Wednesday, March 08 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, March 08 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Wednesday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Wednesday, March 08 | 2:30PM - 4:30PM
Workshop 2
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 1 of 9
* Aimee L. Edinger, University of California, Irvine, USA


Wednesday, March 08 | 2:30PM - 4:30PM
Workshop 2
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 2 of 9
Liron Bar-Peled, The Scripps Research Institute, USA
A Druggable Transcriptional Vulnerability in NRF2-Dependent Lung Cancers


Wednesday, March 08 | 2:30PM - 4:30PM
Workshop 2
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 3 of 9
Volkan I. Sayin, Sahlgrenska Cancer Center, Sweden
Somatic Editing of Keap1/Nrf2 Antioxidant Response is Pro-Tumorigenic and Promotes a Targetable Genotype-Dependent Metabolic Switch in KRAS-Driven Lung Cancer


Wednesday, March 08 | 2:30PM - 4:30PM
Workshop 2
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 4 of 9
Valeria Santoro, Bayer Pharma AG, Germany
Mitochondrial Folate Transporter (SLC25A32) Protects Against ROS-Mediated Cancer Cell Death


Wednesday, March 08 | 2:30PM - 4:30PM
Workshop 2
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 5 of 9
Zhimin Lu, University of Texas MD Anderson Cancer Center, USA
Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy


Wednesday, March 08 | 2:30PM - 4:30PM
Workshop 2
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 6 of 9
Boyi Gan, MD Anderson Cancer Center, USA
LncRNA NBR2 Regulates AMPK-Mediated Energy Stress Response and Modulates Cancer Cell Sensitivity to Biguanides


Wednesday, March 08 | 2:30PM - 4:30PM
Workshop 2
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 7 of 9
Bin Zheng, Harvard Medical School, USA
Targeting Metabolic Vulnerabilities of MDSCs to Enhance the Anti-Tumor Activity of PD-1 Blockade


Wednesday, March 08 | 2:30PM - 4:30PM
Workshop 2
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 8 of 9
Giulia Agnello, Aeglea BioTherapeutics, USA
Therapeutic Depletion of Arginine via Arginase I (AEB1102, Pegzilarginase) Administration Inhibits Tumor Growth and Further Sensitizes the Tumor to Immunotherapy with Anti-PD1 and Anti-PD-L1


Wednesday, March 08 | 2:30PM - 4:30PM
Workshop 2
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 9 of 9
Prasenjit Dey, MD Anderson Cancer Center, USA
Collateral Lethality as a Therapeutic Target in Cancer


Wednesday, March 08 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Wednesday, March 08 | 5:00PM - 7:00PM
Hypoxia and the Tumor Stroma
Room: Sea to Sky B

Speaker 1 of 5
* Ester M. Hammond, University of Oxford, UK

Wednesday, March 08 | 5:00PM - 7:00PM
Hypoxia and the Tumor Stroma
Room: Sea to Sky B

Speaker 2 of 5
M. Celeste Simon, University of Pennsylvania, USA
HIFs and Metabolic Adaptations in Renal Cancer

Wednesday, March 08 | 5:00PM - 7:00PM
Hypoxia and the Tumor Stroma
Room: Sea to Sky B

Speaker 3 of 5
Mia J. Phillipson, Uppsala University, Sweden
Contribution of Immune Cells in Restoration of Hypoxic Tissues

Wednesday, March 08 | 5:00PM - 7:00PM
Hypoxia and the Tumor Stroma
Room: Sea to Sky B

Speaker 4 of 5
Sonia Rocha, University of Liverpool, UK
PBRM1, a Highly Mutated Member of the SWI/SNF Complex in Renal Cancer, has an Unconventional Role in the Control of the Hypoxia Response

Wednesday, March 08 | 5:00PM - 7:00PM
Hypoxia and the Tumor Stroma
Room: Sea to Sky B

Speaker 5 of 5
Jong Park, University of Maryland, Baltimore County, USA
Short Talk: Role of Lactate-NDRG Signaling in Low Oxygen Tolerance

Wednesday, March 08 | 5:00PM - 7:00PM
Interplay with Other Cell Types and Tissues
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 1 of 5
* Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA


Wednesday, March 08 | 5:00PM - 7:00PM
Interplay with Other Cell Types and Tissues
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 2 of 5
Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Biosynthetic Needs of Immune Cells and Effects on Immunotherapy


Wednesday, March 08 | 5:00PM - 7:00PM
Interplay with Other Cell Types and Tissues
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 3 of 5
Nada Y. Kalaany, Boston Children's Hospital at Harvard Medical School, USA
Metabolic Dependencies in Obesity-Associated Pancreatic Cancer


Wednesday, March 08 | 5:00PM - 7:00PM
Interplay with Other Cell Types and Tissues
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 4 of 5
Scott Bultman, University of North Carolina at Chapel Hill, USA
Regulation of Tumor Metabolism by the Microbiome


Wednesday, March 08 | 5:00PM - 7:00PM
Interplay with Other Cell Types and Tissues
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 5 of 5
Costas A. Lyssiotis, University of Michigan, USA
Short Talk: Stromal Support of Pancreatic Tumor Metabolism


Wednesday, March 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Wednesday, March 08 | 7:30PM - 10:00PM
Poster Session 3
Room: Sea to Sky A


Thursday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Thursday, March 09 | 8:00AM - 11:15AM
Hypoxia, Inflammation and Tumor Progression
Room: Sea to Sky B

Speaker 1 of 8
* Emin Maltepe, University of California, San Francisco, USA

Thursday, March 09 | 8:00AM - 11:15AM
Hypoxia, Inflammation and Tumor Progression
Room: Sea to Sky B

Speaker 2 of 8
Amato J. Giaccia, Stanford University, USA
Clear Cell Renal Cancers: Lipid Droplets

Thursday, March 09 | 8:00AM - 11:15AM
Hypoxia, Inflammation and Tumor Progression
Room: Sea to Sky B

Speaker 3 of 8
Cormac Taylor, University College Dublin, Ireland
The Role of Hypoxia in Immunity and Inflammation



Thursday, March 09 | 8:00AM - 11:15AM
Hypoxia, Inflammation and Tumor Progression
Room: Sea to Sky B

Speaker 4 of 8
G-One Ahn, Pohang University of Science and Technology, South Korea
Short Talk: Tumor-Associated Macrophages Can Exacerbate Tumor Hypoxia and Glycolysis

Thursday, March 09 | 8:00AM - 11:15AM
Hypoxia, Inflammation and Tumor Progression
Room: Sea to Sky B


Coffee Break

Thursday, March 09 | 8:00AM - 11:15AM
Hypoxia, Inflammation and Tumor Progression
Room: Sea to Sky B

Speaker 6 of 8
Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance and Lung Metastasis

Thursday, March 09 | 8:00AM - 11:15AM
Hypoxia, Inflammation and Tumor Progression
Room: Sea to Sky B

Speaker 7 of 8
Christian Metallo, University of California, San Diego, USA
Reprogramming of Amino Acid Metabolism by Hypoxia

Thursday, March 09 | 8:00AM - 11:15AM
Hypoxia, Inflammation and Tumor Progression
Room: Sea to Sky B

Speaker 8 of 8
Erinn B. Rankin, Stanford University, USA
Short Talk: Hypoxic Signaling in the Tumor-Mesothelial Niche

Thursday, March 09 | 8:00AM - 11:15AM
Tumor Progression and Suppression by Metabolic Enzymes
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 1 of 8
* Sarah-Maria Fendt, VIB Leuven, Belgium


Thursday, March 09 | 8:00AM - 11:15AM
Tumor Progression and Suppression by Metabolic Enzymes
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 2 of 8
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
CRISPR Screening for Metabolic Dependencies in Cancer Cells


Thursday, March 09 | 8:00AM - 11:15AM
Tumor Progression and Suppression by Metabolic Enzymes
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 3 of 8
Jared Rutter, University of Utah, USA
Pyruvate Metabolism and Cell Fate Decisions


Thursday, March 09 | 8:00AM - 11:15AM
Tumor Progression and Suppression by Metabolic Enzymes
This session is from Tumor Metabolism
Room: Sea to Sky C


Coffee Break


Thursday, March 09 | 8:00AM - 11:15AM
Tumor Progression and Suppression by Metabolic Enzymes
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 5 of 8
Heather Christofk, University of California, Los Angeles, USA
Metabolic Transitions in Cancer: Lessons from Viral Infection


Thursday, March 09 | 8:00AM - 11:15AM
Tumor Progression and Suppression by Metabolic Enzymes
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 6 of 8
Eyal Gottlieb, Technion - Israel Institute of Technology, Israel
Metabolic Dependencies of Leukemic Stem Cells


Thursday, March 09 | 8:00AM - 11:15AM
Tumor Progression and Suppression by Metabolic Enzymes
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 7 of 8
Oliver Maddocks, University of Glasgow, UK
Short Talk: MTAP Deletion and Polyamine Pathway Activity Combine to Confer Cysteine Essentiality in Cancer Cells


Thursday, March 09 | 8:00AM - 11:15AM
Tumor Progression and Suppression by Metabolic Enzymes
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 8 of 8
Susan Demo, Calithera Biosciences, USA
Short Talk: CB-839, a Selective Glutaminase Inhibitor, has Anti-Tumor Activity in Renal Cell Carcinoma and Synergizes with Everolimus and Cabozantinib


Thursday, March 09 | 11:15AM - 12:00PM
Lunch
Room: Sea to Sky A


Thursday, March 09 | 2:30PM - 4:30PM
Workshop 2: Hypoxia and Disease Processes
Room: Sea to Sky B

Speaker 1 of 7
* Peppi Koivunen, University of Oulu, Finland
Notch Downregulation and Extramedullary Erythrocytosis in HIF Prolyl 4-Hydroxylase-2-Deficient Mice

Thursday, March 09 | 2:30PM - 4:30PM
Workshop 2: Hypoxia and Disease Processes
Room: Sea to Sky B

Speaker 2 of 7
* Qing Zhang, UT Southwestern Medical Center, USA
ZHX2 Promotes ccRCC as a Potential pVHL Target by Activating NF-kB

Thursday, March 09 | 2:30PM - 4:30PM
Workshop 2: Hypoxia and Disease Processes
Room: Sea to Sky B

Speaker 3 of 7
Jason Boehme, University of California, San Francisco, USA
Preservation of Myocardial Contractility during Acute Hypoxia with OMX—A Novel Oxygen Delivery Biotherapeutic

Thursday, March 09 | 2:30PM - 4:30PM
Workshop 2: Hypoxia and Disease Processes
Room: Sea to Sky B

Speaker 4 of 7
Sara M. Timpano, University of Guelph, Canada
Human Cells Cultured Under Physiological Oxygen Utilize a Different Mode of Translation Initiation, Have Higher Proliferation Rates, Less Oxidized DNA and More Tubular Mitochondria

Thursday, March 09 | 2:30PM - 4:30PM
Workshop 2: Hypoxia and Disease Processes
Room: Sea to Sky B

Speaker 5 of 7
Norihiko Takeda, University of Tokyo, Japan
HIF-1-PDK1 Axis Induced Active Glycolysis Plays an Essential Role in Macrophage Migratory Capacity

Thursday, March 09 | 2:30PM - 4:30PM
Workshop 2: Hypoxia and Disease Processes
Room: Sea to Sky B

Speaker 6 of 7
Merve Erdem, Uniklinik Aachen, Germany
HIF-1alpha in Myeloid Cells Affects Peripheral Lipid Metabolism in Cancer Cachexia

Thursday, March 09 | 2:30PM - 4:30PM
Workshop 2: Hypoxia and Disease Processes
Room: Sea to Sky B

Speaker 7 of 7
Jamie D. Weyandt, Vanderbilt University Medical Center, USA
Loss of Fumarate Hydratase Upregulates Glycolytic Metabolism in a Mouse Renal Carcinoma Cell Line

Thursday, March 09 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Thursday, March 09 | 5:00PM - 6:45PM
O2 Availability and Stress Responses
Room: Sea to Sky B

Speaker 1 of 4
* Randall S. Johnson, University of Cambridge, UK

Thursday, March 09 | 5:00PM - 6:45PM
O2 Availability and Stress Responses
Room: Sea to Sky B

Speaker 2 of 4
Constantinos Koumenis, University of Pennsylvania, USA
Genome-Wide Analysis of Hypoxic Responses in Cells and Tumors Reveals Novel Splicing Pathways Impacting Macromolecular Synthesis

Thursday, March 09 | 5:00PM - 6:45PM
O2 Availability and Stress Responses
Room: Sea to Sky B

Speaker 3 of 4
Bradly G. Wouters, University Health Network, Canada
ULK1 Regulates Oxygen Metabolism, Hypoxia Tolerance and Is a Therapeutic Target in Pancreatic Cancer

Thursday, March 09 | 5:00PM - 6:45PM
O2 Availability and Stress Responses
Room: Sea to Sky B

Speaker 4 of 4
Ester M. Hammond, University of Oxford, UK
Ribonucleotide Reductase Favors the RRM2B Subunit to Maintain DNA Replication in Hypoxia

Thursday, March 09 | 5:00PM - 6:45PM
Metabolic Vulnerabilities in Cancer
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 1 of 4
* Almut Schulze, University of Würzburg/Theodor-Boveri Institute, Germany


Thursday, March 09 | 5:00PM - 6:45PM
Metabolic Vulnerabilities in Cancer
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 2 of 4
Eileen P. White, Rutgers University, USA
Inhibiting Autophagy as a Cancer Therapy


Thursday, March 09 | 5:00PM - 6:45PM
Metabolic Vulnerabilities in Cancer
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 3 of 4
Katya Marjon, Agios Pharmaceuticals, USA
Metabolic Collateral Vulnerabilities of MTAP-Deleted Cancers as Therapeutic Opportunities


Thursday, March 09 | 5:00PM - 6:45PM
Metabolic Vulnerabilities in Cancer
This session is from Tumor Metabolism
Room: Sea to Sky C

Speaker 4 of 4
Reuben J. Shaw, The Salk Institute for Biological Studies, USA
The AMPK Pathway: Cancer Fighter, Cancer Promoter


Thursday, March 09 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Sea to Sky B


Thursday, March 09 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Tumor Metabolism
Room: Sea to Sky C


Thursday, March 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Thursday, March 09 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 09 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Friday, March 10 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.