Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Hypoxia: Molecules, Mechanisms and Disease (2020A3)
Therapeutic Targeting of Hypoxia-Sensitive Pathways (2018V1)

Web Desc
Adaptations to Hypoxia in Physiology and Disease joint with Tumor Metabolism: Mechanisms and Targets Organizer(s): M. Celeste Simon, Amato J. Giaccia and Randall S. Johnson Date: March 05 - 09, 2017 Location: Whistler Conference Centre, Whistler, BC, Canada Sponsored by Takeda Pharmaceutical Company Limited For important information on the coronavirus, please click here Summary of Meeting: Cellular responses to changes in oxygen availability have important implications for both physiology and pathophysiology, in particular in the setting of solid tumor progression. A number of hypoxia-inducible pathways have been characterized, such as the large transcriptome regulated by hypoxia-inducible factors (HIFs). However, many other oxygen-sensing pathways exist within the cell. The aim of this meeting is to disseminate up-to-date information on basic mechanisms of cellular and tissue hypoxia responses, and discuss the impact of these responses on physiology and cancer, with an emphasis on HIF-independent, but nevertheless fundamental, oxygen-sensing pathways. Outcomes of this meeting will include the dissemination of new scientific knowledge, the discussion of new methodologies, the education of graduate students and postdoctoral fellows in this discipline, and promotion of new collaborations between clinicians, basic researchers and industrial partners. This will be the eighth Keystone Symposia meeting on Hypoxia, which brings together academic, clinical and industrial researchers to enhance synergy between these groups and develop translational strategies for targeting hypoxic stress responses for therapeutic benefit. Scholarship Deadline: November 8 2016 Discounted Abstract Deadline: November 8 2016 Abstract Deadline: December 8 2016 Discounted Registration Deadline: January 12 2017 Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested. Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Peloton Therapeutics We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Adaptations to Hypoxia in Physiology and Disease

joint with Tumor Metabolism: Mechanisms and Targets

Organizer(s): M. Celeste Simon, Amato J. Giaccia and Randall S. Johnson

Date: March 05 - 09, 2017
Location: Whistler Conference Centre, Whistler, BC, Canada

Sponsored by Takeda Pharmaceutical Company Limited

For important information on the coronavirus, please click here

Summary of Meeting:

Cellular responses to changes in oxygen availability have important implications for both physiology and pathophysiology, in particular in the setting of solid tumor progression. A number of hypoxia-inducible pathways have been characterized, such as the large transcriptome regulated by hypoxia-inducible factors (HIFs). However, many other oxygen-sensing pathways exist within the cell. The aim of this meeting is to disseminate up-to-date information on basic mechanisms of cellular and tissue hypoxia responses, and discuss the impact of these responses on physiology and cancer, with an emphasis on HIF-independent, but nevertheless fundamental, oxygen-sensing pathways. Outcomes of this meeting will include the dissemination of new scientific knowledge, the discussion of new methodologies, the education of graduate students and postdoctoral fellows in this discipline, and promotion of new collaborations between clinicians, basic researchers and industrial partners. This will be the eighth Keystone Symposia meeting on Hypoxia, which brings together academic, clinical and industrial researchers to enhance synergy between these groups and develop translational strategies for targeting hypoxic stress responses for therapeutic benefit.

Scholarship Deadline: November 8 2016

Discounted Abstract Deadline: November 8 2016

Abstract Deadline: December 8 2016

Discounted Registration Deadline: January 12 2017

Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Peloton Therapeutics

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, March 05 \| 4:00PM - 8:00PM Arrival and Registration Room: Grand Foyer
Sunday, March 05 \| 6:00PM - 8:00PM Welcome Mixer Room: Grand Foyer No registration fees are used to fund alcohol served at this function.
Monday, March 06 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky A
Monday, March 06 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Sea to Sky B/C Speaker 1 of 2 * M. Celeste Simon, University of Pennsylvania, USA
Monday, March 06 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Sea to Sky B/C Speaker 2 of 2 Chi Van Dang, University of Pennsylvania, USA MYC as the Master Regulator of Proliferative Metabolism
Monday, March 06 \| 9:00AM - 11:30AM Hypoxia and Tumor Metabolism (Joint) Room: Sea to Sky B/C Speaker 1 of 7 * Amato J. Giaccia, Stanford University, USA
Monday, March 06 \| 9:00AM - 11:30AM Hypoxia and Tumor Metabolism (Joint) Room: Sea to Sky B/C Speaker 2 of 7 William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA 2-Oxoglutarate-Dependent Dioxygenases and Cancer
Monday, March 06 \| 9:00AM - 11:30AM Hypoxia and Tumor Metabolism (Joint) Room: Sea to Sky B/C Coffee Break
Monday, March 06 \| 9:00AM - 11:30AM Hypoxia and Tumor Metabolism (Joint) Room: Sea to Sky B/C Speaker 4 of 7 Nicholas Denko, Ohio State University, USA Hypoxic Regulation of Mitochondrial Function
Monday, March 06 \| 9:00AM - 11:30AM Hypoxia and Tumor Metabolism (Joint) Room: Sea to Sky B/C Speaker 5 of 7 Andrew M. Intlekofer, Memorial Sloan Kettering Cancer Center, USA Short Talk: Acidification Enhances Production of L-2-Hydroxyglutarate through Alternative Substrate use by Dehydrogenase Enzymes
Monday, March 06 \| 9:00AM - 11:30AM Hypoxia and Tumor Metabolism (Joint) Room: Sea to Sky B/C Speaker 6 of 7 James A. Nathan, Cambridge Institute for Medical Research, UK Short Talk: Oxygen Sensing and Metabolism: The Role of the 2-Oxoglutarate Dehydrogenase Complex and Mitochondrial Protein Lipoylation
Monday, March 06 \| 9:00AM - 11:30AM Hypoxia and Tumor Metabolism (Joint) Room: Sea to Sky B/C Speaker 7 of 7 Karen H. Vousden, Francis Crick Institute, UK A Role for p53 in the Adaptation to Metabolic Stress
Monday, March 06 \| 11:15AM - 5:00PM On Own for Lunch
Monday, March 06 \| 11:15AM - 1:00PM Poster Setup Room: Sea to Sky A
Monday, March 06 \| 1:00PM - 10:00PM Poster Viewing Room: Sea to Sky A
Monday, March 06 \| 2:30PM - 4:30PM Workshop 1 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 1 of 9 * Costas A. Lyssiotis, University of Michigan, USA
Monday, March 06 \| 2:30PM - 4:30PM Workshop 1 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 2 of 9 Sumin Kang, Emory University, USA Phosphorylation-Mediated Activation of Lactate Dehydrogenase A Promotes Cancer Cell Invasion and Tumor Metastasis
Monday, March 06 \| 2:30PM - 4:30PM Workshop 1 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 3 of 9 Issam Ben-Sahra, Northwestern University, USA Nucleotide Sensing by the mTORC1 Signaling Network
Monday, March 06 \| 2:30PM - 4:30PM Workshop 1 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 4 of 9 Atsuo T. Sasaki, University of Cincinnati, USA SSK2 Couples Nucleolar Transcription and Anabolic GTP Metabolism for Gliomagenesis
Monday, March 06 \| 2:30PM - 4:30PM Workshop 1 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 5 of 9 Isaac Spencer Harris, University of Rochester, USA Understanding the Vulnerabilities in Cancer Cells Upon Inhibition of Glutathione Synthesis
Monday, March 06 \| 2:30PM - 4:30PM Workshop 1 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 6 of 9 Won Dong Lee, Princeton University, USA Inferring Compartmentalized Mitochondrial, Nuclear, and Cytosolic Metabolic Fluxes via Isotope Tracing with Cell Fractionation
Monday, March 06 \| 2:30PM - 4:30PM Workshop 1 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 7 of 9 Lauren E. Drake, University of Chicago, USA BNip3 Loss Promotes Hepatocellular Carcinoma Growth through Increased Lipogenesis
Monday, March 06 \| 2:30PM - 4:30PM Workshop 1 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 8 of 9 Salvador Aznar Benitah, ICREA and Institute for Research in Biomedicine, Spain Identifying and Targeting Metastatic-Initiating Cells through the Fatty Acid Receptor CD36
Monday, March 06 \| 2:30PM - 4:30PM Workshop 1 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 9 of 9 Jing Chen, Winship Cancer Institute, Emory University, USA Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth
Monday, March 06 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Monday, March 06 \| 5:00PM - 7:00PM Hypoxic Influences on Intracellular and Tissue Homeostasis Room: Sea to Sky B Speaker 1 of 5 * Richard K. Bruick, University of Texas Southwestern Medical Center, USA
Monday, March 06 \| 5:00PM - 7:00PM Hypoxic Influences on Intracellular and Tissue Homeostasis Room: Sea to Sky B Speaker 2 of 5 Young Il Yeom, Korea Research Institute of Bioscience and Biotechnology, South Korea Lactate-Induced Responses to Hypoxia
Monday, March 06 \| 5:00PM - 7:00PM Hypoxic Influences on Intracellular and Tissue Homeostasis Room: Sea to Sky B Speaker 3 of 5 Geert Carmeliet, KU Leuven, Belgium Glutamine, Glycogen and Bioenergetics
Monday, March 06 \| 5:00PM - 7:00PM Hypoxic Influences on Intracellular and Tissue Homeostasis Room: Sea to Sky B Speaker 4 of 5 Othon Iliopoulos, Massachusetts General Hospital Cancer Center, USA Glutaminase and PARP Inhibitors Synergistically Suppress ROS and Pyrimidine Dependent Growth of VHL-Deficient Renal Cell Cancer: A Novel Strategy for Treatment of Hypoxia-Driven and HIF-Expressing Tumors
Monday, March 06 \| 5:00PM - 7:00PM Hypoxic Influences on Intracellular and Tissue Homeostasis Room: Sea to Sky B Speaker 5 of 5 Thomas Markus Leissing, University of Oxford, UK Short Talk: Structural Basis for the Inhibition of Prolyl-Hydroxylase Domain Containing Proteins (PHDs) by Clinical Candidates for Anaemia Treatment
Monday, March 06 \| 5:00PM - 7:00PM Oncogenic Control of Metabolism This session is from Tumor Metabolism Room: Sea to Sky C Speaker 1 of 5 * Heather Christofk, University of California, Los Angeles, USA
Monday, March 06 \| 5:00PM - 7:00PM Oncogenic Control of Metabolism This session is from Tumor Metabolism Room: Sea to Sky C Speaker 2 of 5 Lewis C. Cantley, Weill Cornell Medicine, USA PI3K Signaling and Glucose Metabolism in Tumors
Monday, March 06 \| 5:00PM - 7:00PM Oncogenic Control of Metabolism This session is from Tumor Metabolism Room: Sea to Sky C Speaker 3 of 5 Almut Schulze, University of Würzburg/Theodor-Boveri Institute, Germany Targeting Glucose and Lipid Metabolism in Cancer
Monday, March 06 \| 5:00PM - 7:00PM Oncogenic Control of Metabolism This session is from Tumor Metabolism Room: Sea to Sky C Speaker 4 of 5 Brendan D. Manning, Harvard School of Public Health, USA A Coordinated Anabolic Program Downstream of mTOR
Monday, March 06 \| 5:00PM - 7:00PM Oncogenic Control of Metabolism This session is from Tumor Metabolism Room: Sea to Sky C Speaker 5 of 5 Alejo Efeyan, Spanish National Cancer Research Institute, Spain Short Talk: Oncogenic Mutations in the Nutrient Sensing Pathway Upstream of mTORC1 Alter B Lymphocyte Functions in Novel Genetically-engineered Mice
Monday, March 06 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Sea to Sky A No registration fees are used to fund alcohol served at this function.
Monday, March 06 \| 7:30PM - 10:00PM Poster Session 1 Room: Sea to Sky A
Tuesday, March 07 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky A
Tuesday, March 07 \| 8:00AM - 11:15AM Physiological Responses to Hypoxia Room: Sea to Sky B Speaker 1 of 8 * Maria F. Czyzyk-Krzeska, University of Cincinnati, USA
Tuesday, March 07 \| 8:00AM - 11:15AM Physiological Responses to Hypoxia Room: Sea to Sky B Speaker 2 of 8 Peter F. Carmeliet, University of Leuven, VIB, Belgium Metabolic Adaptations of Tumor Blood Vessels
Tuesday, March 07 \| 8:00AM - 11:15AM Physiological Responses to Hypoxia Room: Sea to Sky B Speaker 3 of 8 Frank S. Lee, University of Pennsylvania School of Medicine, USA Short Talk: Studies on the Zinc Finger of Prolyl Hydroxylase Domain Protein 2 (PHD2), a Hypoxia Inducible Factor-alpha Hydroxylase
Tuesday, March 07 \| 8:00AM - 11:15AM Physiological Responses to Hypoxia Room: Sea to Sky B Speaker 4 of 8 Francisco J. Quintana, Harvard Medical School, USA Regulation of CNS Inflammation by Hypoxia-Responsive Signaling
Tuesday, March 07 \| 8:00AM - 11:15AM Physiological Responses to Hypoxia Room: Sea to Sky B Coffee Break
Tuesday, March 07 \| 8:00AM - 11:15AM Physiological Responses to Hypoxia Room: Sea to Sky B Speaker 6 of 8 Mark R. Boothby, Vanderbilt University Medical Center, USA Short Talk: Germinal Center Hypoxia and Regulation of mTORC1 Activity in B Cells Shape Antibody Response Qualities
Tuesday, March 07 \| 8:00AM - 11:15AM Physiological Responses to Hypoxia Room: Sea to Sky B Speaker 7 of 8 Janine T. Erler, University of Copenhagen, Denmark Hypoxia-Driven ECM Remodelling during Cancer Progression
Tuesday, March 07 \| 8:00AM - 11:15AM Physiological Responses to Hypoxia Room: Sea to Sky B Speaker 8 of 8 Navdeep S. Chandel, Northwestern University, USA Why Mammalian Cells Respire?
Tuesday, March 07 \| 8:00AM - 11:15AM Metabolic Strategies in Cancer This session is from Tumor Metabolism Room: Sea to Sky C Speaker 1 of 8 * Jared Rutter, University of Utah, USA
Tuesday, March 07 \| 8:00AM - 11:15AM Metabolic Strategies in Cancer This session is from Tumor Metabolism Room: Sea to Sky C Speaker 2 of 8 Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA Metabolic Adaptations to Allow Tumor Cell Proliferation
Tuesday, March 07 \| 8:00AM - 11:15AM Metabolic Strategies in Cancer This session is from Tumor Metabolism Room: Sea to Sky C Speaker 3 of 8 Jurre J. Kamphorst, Rheos Medicines, USA Triglycerides Buffer Membrane Phospholipid Saturation during Hypoxic Stress
Tuesday, March 07 \| 8:00AM - 11:15AM Metabolic Strategies in Cancer This session is from Tumor Metabolism Room: Sea to Sky C Coffee Break
Tuesday, March 07 \| 8:00AM - 11:15AM Metabolic Strategies in Cancer This session is from Tumor Metabolism Room: Sea to Sky C Speaker 5 of 8 Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA Heterogeneous Metabolic Phenotypes and Liabilities in Human Cancer
Tuesday, March 07 \| 8:00AM - 11:15AM Metabolic Strategies in Cancer This session is from Tumor Metabolism Room: Sea to Sky C Speaker 6 of 8 Sarah-Maria Fendt, VIB Leuven, Belgium Cancer Metabolism during Metastasis Formation
Tuesday, March 07 \| 8:00AM - 11:15AM Metabolic Strategies in Cancer This session is from Tumor Metabolism Room: Sea to Sky C Speaker 7 of 8 Cosimo Commisso, Sanford Burnham Prebys Medical Discovery Institute, USA Short Talk: Not Dying of Starvation: Nutrient Stress Controls Macropinocytosis in Tumor Cells
Tuesday, March 07 \| 8:00AM - 11:15AM Metabolic Strategies in Cancer This session is from Tumor Metabolism Room: Sea to Sky C Speaker 8 of 8 Elizabeth Petri Henske, Brigham and Women's Hospital, USA Short Talk: Therapeutic Targeting of mTORC1-Dependent Metabolic Vulnerabilities in TSC and LAM
Tuesday, March 07 \| 11:15AM - 2:30PM On Own for Lunch
Tuesday, March 07 \| 11:15AM - 1:00PM Poster Setup Room: Sea to Sky A
Tuesday, March 07 \| 1:00PM - 10:00PM Poster Viewing Room: Sea to Sky A
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1: Fundamental Processes of Oxygen Sensing Room: Sea to Sky B Speaker 1 of 7 James A. Smythies, University of Oxford, UK Utilisation of Next Generation Sequencing Technologies to Identify Novel Contributors to Hypoxia Inducible Factor Binding Site Selectivity
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1: Fundamental Processes of Oxygen Sensing Room: Sea to Sky B Speaker 2 of 7 * Luis del Peso, Universidad Autonoma, Spain Transcriptional Repression in Hypoxia is Mediated by the Sin3A Histone Deacetylase Complex
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1: Fundamental Processes of Oxygen Sensing Room: Sea to Sky B Speaker 3 of 7 Johannes Schödel, Universitätsklinikum Erlangen, Germany Complex Regulation of Glucose Transporter 3 Expression by HIF
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1: Fundamental Processes of Oxygen Sensing Room: Sea to Sky B Speaker 4 of 7 Andrew Fraser, University of Toronto, Canada How Worms Hold Their Breath: The Unusual Metabolic Response of Nematodes to Hypoxia and the Importance for 2 Billion Humans
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1: Fundamental Processes of Oxygen Sensing Room: Sea to Sky B Speaker 5 of 7 Roman Vozdek, University of California, San Francisco, USA Novel Uncharacterized Protein Tyrosine Kinase Senses Hypoxia to Mediate HIF-1 Independent Transcriptional Response in C. elegans
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1: Fundamental Processes of Oxygen Sensing Room: Sea to Sky B Speaker 6 of 7 Austin Gabel, University of Maryland, Baltimore County, USA Understanding Induction of Suspended Animation In Zebrafish
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1: Fundamental Processes of Oxygen Sensing Room: Sea to Sky B Speaker 7 of 7 Farhad B. Imam, Bill & Melinda Gates Foundation, USA Cellular and Metabolic Studies of Hypoxia-Sensitive Mutants in irs2 and ctrc3, Key Regulators of Glucose and Fatty Acid Metabolism
Tuesday, March 07 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Tuesday, March 07 \| 5:00PM - 7:00PM Metabolic Adaptations of Cells within the Tumor Microenviron ment (Joint) Room: Sea to Sky B/C Speaker 1 of 5 * Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Tuesday, March 07 \| 5:00PM - 7:00PM Metabolic Adaptations of Cells within the Tumor Microenviron ment (Joint) Room: Sea to Sky B/C Speaker 2 of 5 Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA The Functional Contribution of Exosomes in Cancer Metabolism and Metastasis
Tuesday, March 07 \| 5:00PM - 7:00PM Metabolic Adaptations of Cells within the Tumor Microenviron ment (Joint) Room: Sea to Sky B/C Speaker 3 of 5 Randall S. Johnson, University of Cambridge, UK The Metabolic Role of Hypoxic Response in T Cell Activation
Tuesday, March 07 \| 5:00PM - 7:00PM Metabolic Adaptations of Cells within the Tumor Microenviron ment (Joint) Room: Sea to Sky B/C Speaker 4 of 5 Shannon J. Turley, Genentech, Inc., USA Leukocyte Function and Positioning in Diverse Stromal Niches
Tuesday, March 07 \| 5:00PM - 7:00PM Metabolic Adaptations of Cells within the Tumor Microenviron ment (Joint) Room: Sea to Sky B/C Speaker 5 of 5 Hong Xie, University of Pennsylvania, USA Short Talk: Balancing Anabolic Metabolism with Homeostatic Stress Responses in Myc-Transformed Cancer Cells
Tuesday, March 07 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Sea to Sky A No registration fees are used to fund alcohol served at this function.
Tuesday, March 07 \| 7:30PM - 10:00PM Poster Session 2 Room: Sea to Sky A
Wednesday, March 08 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky A
Wednesday, March 08 \| 8:00AM - 11:15AM Biochemical and Epigenetic Responses to Hypoxia Room: Sea to Sky B Speaker 1 of 8 * Frank S. Lee, University of Pennsylvania School of Medicine, USA
Wednesday, March 08 \| 8:00AM - 11:15AM Biochemical and Epigenetic Responses to Hypoxia Room: Sea to Sky B Speaker 2 of 8 Peter J. Ratcliffe, University of Oxford, UK Genome Wide Studies of the Hypoxia Transcriptome
Wednesday, March 08 \| 8:00AM - 11:15AM Biochemical and Epigenetic Responses to Hypoxia Room: Sea to Sky B Speaker 3 of 8 Daniel Cooper, Duke University School of Medicine, USA Short Talk: Hypoxia and Radiation Regulate HIF1alpha Gene Targets in a Context-Dependent manner
Wednesday, March 08 \| 8:00AM - 11:15AM Biochemical and Epigenetic Responses to Hypoxia Room: Sea to Sky B Speaker 4 of 8 Fraydoon Rastinejad, University of Oxford, UK Structures and Drug-Binding Potentials of HIF-alpha-ARNT Heterodimers
Wednesday, March 08 \| 8:00AM - 11:15AM Biochemical and Epigenetic Responses to Hypoxia Room: Sea to Sky B Coffee Break
Wednesday, March 08 \| 8:00AM - 11:15AM Biochemical and Epigenetic Responses to Hypoxia Room: Sea to Sky B Speaker 6 of 8 Isha Jain, Massachusetts General Hospital, USA Short Talk: Hypoxia as a Therapy for Mitochondrial Disease
Wednesday, March 08 \| 8:00AM - 11:15AM Biochemical and Epigenetic Responses to Hypoxia Room: Sea to Sky B Speaker 7 of 8 Eli M. Wallace, Merck, USA Small Molecule HIF-2a Antagonists and Their Therapeutic Applications
Wednesday, March 08 \| 8:00AM - 11:15AM Biochemical and Epigenetic Responses to Hypoxia Room: Sea to Sky B Speaker 8 of 8 Maria F. Czyzyk-Krzeska, University of Cincinnati, USA Oncogenic and Tumor Suppressive Autophagic Programs in Renal Cell Carcinoma
Wednesday, March 08 \| 8:00AM - 11:15AM Metabolism, Signaling and Epigenetics This session is from Tumor Metabolism Room: Sea to Sky C Speaker 1 of 8 * Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Wednesday, March 08 \| 8:00AM - 11:15AM Metabolism, Signaling and Epigenetics This session is from Tumor Metabolism Room: Sea to Sky C Speaker 2 of 8 Aimee L. Edinger, University of California, Irvine, USA Macropinocytosis Drives Cancer Cell Growth in Both Nutrient-Limiting and-Replete Conditions
Wednesday, March 08 \| 8:00AM - 11:15AM Metabolism, Signaling and Epigenetics This session is from Tumor Metabolism Room: Sea to Sky C Speaker 3 of 8 Jason Locasale, Duke University School of Medicine, USA Diet, Cancer, and Epigenetics
Wednesday, March 08 \| 8:00AM - 11:15AM Metabolism, Signaling and Epigenetics This session is from Tumor Metabolism Room: Sea to Sky C Coffee Break
Wednesday, March 08 \| 8:00AM - 11:15AM Metabolism, Signaling and Epigenetics This session is from Tumor Metabolism Room: Sea to Sky C Speaker 5 of 8 Joshua D. Rabinowitz, Princeton University, USA Multiple Functions of Mitochondrial Folate Metabolism
Wednesday, March 08 \| 8:00AM - 11:15AM Metabolism, Signaling and Epigenetics This session is from Tumor Metabolism Room: Sea to Sky C Speaker 6 of 8 Kathryn E. Wellen, University of Pennsylvania, USA Acetyl-CoA at the Crossroads of Metabolism and Epigenetics
Wednesday, March 08 \| 8:00AM - 11:15AM Metabolism, Signaling and Epigenetics This session is from Tumor Metabolism Room: Sea to Sky C Speaker 7 of 8 Christian C. Dibble, Beth Israel Deaconess Medical Center, USA Short Talk: PI3K Signaling Controls de novo Biosynthesis of Coenzyme A from Vitamin B5
Wednesday, March 08 \| 8:00AM - 11:15AM Metabolism, Signaling and Epigenetics This session is from Tumor Metabolism Room: Sea to Sky C Speaker 8 of 8 Jordan Meier, NCI, National Institutes of Health, USA Short Talk: Defining Metabolic Mechanisms of Epigenetic Signaling using Chemoproteomics
Wednesday, March 08 \| 11:15AM - 5:00PM On Own for Lunch
Wednesday, March 08 \| 11:15AM - 1:00PM Poster Setup Room: Sea to Sky A
Wednesday, March 08 \| 1:00PM - 10:00PM Poster Viewing Room: Sea to Sky A
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop 2 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 1 of 9 * Aimee L. Edinger, University of California, Irvine, USA
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop 2 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 2 of 9 Liron Bar-Peled, The Scripps Research Institute, USA A Druggable Transcriptional Vulnerability in NRF2-Dependent Lung Cancers
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop 2 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 3 of 9 Volkan I. Sayin, Sahlgrenska Cancer Center, Sweden Somatic Editing of Keap1/Nrf2 Antioxidant Response is Pro-Tumorigenic and Promotes a Targetable Genotype-Dependent Metabolic Switch in KRAS-Driven Lung Cancer
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop 2 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 4 of 9 Valeria Santoro, Bayer Pharma AG, Germany Mitochondrial Folate Transporter (SLC25A32) Protects Against ROS-Mediated Cancer Cell Death
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop 2 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 5 of 9 Zhimin Lu, University of Texas MD Anderson Cancer Center, USA Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop 2 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 6 of 9 Boyi Gan, MD Anderson Cancer Center, USA LncRNA NBR2 Regulates AMPK-Mediated Energy Stress Response and Modulates Cancer Cell Sensitivity to Biguanides
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop 2 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 7 of 9 Bin Zheng, Harvard Medical School, USA Targeting Metabolic Vulnerabilities of MDSCs to Enhance the Anti-Tumor Activity of PD-1 Blockade
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop 2 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 8 of 9 Giulia Agnello, Aeglea BioTherapeutics, USA Therapeutic Depletion of Arginine via Arginase I (AEB1102, Pegzilarginase) Administration Inhibits Tumor Growth and Further Sensitizes the Tumor to Immunotherapy with Anti-PD1 and Anti-PD-L1
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop 2 This session is from Tumor Metabolism Room: Sea to Sky C Speaker 9 of 9 Prasenjit Dey, MD Anderson Cancer Center, USA Collateral Lethality as a Therapeutic Target in Cancer
Wednesday, March 08 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Wednesday, March 08 \| 5:00PM - 7:00PM Hypoxia and the Tumor Stroma Room: Sea to Sky B Speaker 1 of 5 * Ester M. Hammond, University of Oxford, UK
Wednesday, March 08 \| 5:00PM - 7:00PM Hypoxia and the Tumor Stroma Room: Sea to Sky B Speaker 2 of 5 M. Celeste Simon, University of Pennsylvania, USA HIFs and Metabolic Adaptations in Renal Cancer
Wednesday, March 08 \| 5:00PM - 7:00PM Hypoxia and the Tumor Stroma Room: Sea to Sky B Speaker 3 of 5 Mia J. Phillipson, Uppsala University, Sweden Contribution of Immune Cells in Restoration of Hypoxic Tissues
Wednesday, March 08 \| 5:00PM - 7:00PM Hypoxia and the Tumor Stroma Room: Sea to Sky B Speaker 4 of 5 Sonia Rocha, University of Liverpool, UK PBRM1, a Highly Mutated Member of the SWI/SNF Complex in Renal Cancer, has an Unconventional Role in the Control of the Hypoxia Response
Wednesday, March 08 \| 5:00PM - 7:00PM Hypoxia and the Tumor Stroma Room: Sea to Sky B Speaker 5 of 5 Jong Park, University of Maryland, Baltimore County, USA Short Talk: Role of Lactate-NDRG Signaling in Low Oxygen Tolerance
Wednesday, March 08 \| 5:00PM - 7:00PM Interplay with Other Cell Types and Tissues This session is from Tumor Metabolism Room: Sea to Sky C Speaker 1 of 5 * Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Wednesday, March 08 \| 5:00PM - 7:00PM Interplay with Other Cell Types and Tissues This session is from Tumor Metabolism Room: Sea to Sky C Speaker 2 of 5 Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany Biosynthetic Needs of Immune Cells and Effects on Immunotherapy
Wednesday, March 08 \| 5:00PM - 7:00PM Interplay with Other Cell Types and Tissues This session is from Tumor Metabolism Room: Sea to Sky C Speaker 3 of 5 Nada Y. Kalaany, Boston Children's Hospital at Harvard Medical School, USA Metabolic Dependencies in Obesity-Associated Pancreatic Cancer
Wednesday, March 08 \| 5:00PM - 7:00PM Interplay with Other Cell Types and Tissues This session is from Tumor Metabolism Room: Sea to Sky C Speaker 4 of 5 Scott Bultman, University of North Carolina at Chapel Hill, USA Regulation of Tumor Metabolism by the Microbiome
Wednesday, March 08 \| 5:00PM - 7:00PM Interplay with Other Cell Types and Tissues This session is from Tumor Metabolism Room: Sea to Sky C Speaker 5 of 5 Costas A. Lyssiotis, University of Michigan, USA Short Talk: Stromal Support of Pancreatic Tumor Metabolism
Wednesday, March 08 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Sea to Sky A No registration fees are used to fund alcohol served at this function.
Wednesday, March 08 \| 7:30PM - 10:00PM Poster Session 3 Room: Sea to Sky A
Thursday, March 09 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky A
Thursday, March 09 \| 8:00AM - 11:15AM Hypoxia, Inflammation and Tumor Progression Room: Sea to Sky B Speaker 1 of 8 * Emin Maltepe, University of California, San Francisco, USA
Thursday, March 09 \| 8:00AM - 11:15AM Hypoxia, Inflammation and Tumor Progression Room: Sea to Sky B Speaker 2 of 8 Amato J. Giaccia, Stanford University, USA Clear Cell Renal Cancers: Lipid Droplets
Thursday, March 09 \| 8:00AM - 11:15AM Hypoxia, Inflammation and Tumor Progression Room: Sea to Sky B Speaker 3 of 8 Cormac Taylor, University College Dublin, Ireland The Role of Hypoxia in Immunity and Inflammation
Thursday, March 09 \| 8:00AM - 11:15AM Hypoxia, Inflammation and Tumor Progression Room: Sea to Sky B Speaker 4 of 8 G-One Ahn, Pohang University of Science and Technology, South Korea Short Talk: Tumor-Associated Macrophages Can Exacerbate Tumor Hypoxia and Glycolysis
Thursday, March 09 \| 8:00AM - 11:15AM Hypoxia, Inflammation and Tumor Progression Room: Sea to Sky B Coffee Break
Thursday, March 09 \| 8:00AM - 11:15AM Hypoxia, Inflammation and Tumor Progression Room: Sea to Sky B Speaker 6 of 8 Gregg L. Semenza, Johns Hopkins University School of Medicine, USA PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance and Lung Metastasis
Thursday, March 09 \| 8:00AM - 11:15AM Hypoxia, Inflammation and Tumor Progression Room: Sea to Sky B Speaker 7 of 8 Christian Metallo, University of California, San Diego, USA Reprogramming of Amino Acid Metabolism by Hypoxia
Thursday, March 09 \| 8:00AM - 11:15AM Hypoxia, Inflammation and Tumor Progression Room: Sea to Sky B Speaker 8 of 8 Erinn B. Rankin, Stanford University, USA Short Talk: Hypoxic Signaling in the Tumor-Mesothelial Niche
Thursday, March 09 \| 8:00AM - 11:15AM Tumor Progression and Suppression by Metabolic Enzymes This session is from Tumor Metabolism Room: Sea to Sky C Speaker 1 of 8 * Sarah-Maria Fendt, VIB Leuven, Belgium
Thursday, March 09 \| 8:00AM - 11:15AM Tumor Progression and Suppression by Metabolic Enzymes This session is from Tumor Metabolism Room: Sea to Sky C Speaker 2 of 8 David M. Sabatini, Whitehead Institute for Biomedical Research, USA CRISPR Screening for Metabolic Dependencies in Cancer Cells
Thursday, March 09 \| 8:00AM - 11:15AM Tumor Progression and Suppression by Metabolic Enzymes This session is from Tumor Metabolism Room: Sea to Sky C Speaker 3 of 8 Jared Rutter, University of Utah, USA Pyruvate Metabolism and Cell Fate Decisions
Thursday, March 09 \| 8:00AM - 11:15AM Tumor Progression and Suppression by Metabolic Enzymes This session is from Tumor Metabolism Room: Sea to Sky C Coffee Break
Thursday, March 09 \| 8:00AM - 11:15AM Tumor Progression and Suppression by Metabolic Enzymes This session is from Tumor Metabolism Room: Sea to Sky C Speaker 5 of 8 Heather Christofk, University of California, Los Angeles, USA Metabolic Transitions in Cancer: Lessons from Viral Infection
Thursday, March 09 \| 8:00AM - 11:15AM Tumor Progression and Suppression by Metabolic Enzymes This session is from Tumor Metabolism Room: Sea to Sky C Speaker 6 of 8 Eyal Gottlieb, Technion - Israel Institute of Technology, Israel Metabolic Dependencies of Leukemic Stem Cells
Thursday, March 09 \| 8:00AM - 11:15AM Tumor Progression and Suppression by Metabolic Enzymes This session is from Tumor Metabolism Room: Sea to Sky C Speaker 7 of 8 Oliver Maddocks, University of Glasgow, UK Short Talk: MTAP Deletion and Polyamine Pathway Activity Combine to Confer Cysteine Essentiality in Cancer Cells
Thursday, March 09 \| 8:00AM - 11:15AM Tumor Progression and Suppression by Metabolic Enzymes This session is from Tumor Metabolism Room: Sea to Sky C Speaker 8 of 8 Susan Demo, Calithera Biosciences, USA Short Talk: CB-839, a Selective Glutaminase Inhibitor, has Anti-Tumor Activity in Renal Cell Carcinoma and Synergizes with Everolimus and Cabozantinib
Thursday, March 09 \| 11:15AM - 12:00PM Lunch Room: Sea to Sky A
Thursday, March 09 \| 2:30PM - 4:30PM Workshop 2: Hypoxia and Disease Processes Room: Sea to Sky B Speaker 1 of 7 * Peppi Koivunen, University of Oulu, Finland Notch Downregulation and Extramedullary Erythrocytosis in HIF Prolyl 4-Hydroxylase-2-Deficient Mice
Thursday, March 09 \| 2:30PM - 4:30PM Workshop 2: Hypoxia and Disease Processes Room: Sea to Sky B Speaker 2 of 7 * Qing Zhang, UT Southwestern Medical Center, USA ZHX2 Promotes ccRCC as a Potential pVHL Target by Activating NF-kB
Thursday, March 09 \| 2:30PM - 4:30PM Workshop 2: Hypoxia and Disease Processes Room: Sea to Sky B Speaker 3 of 7 Jason Boehme, University of California, San Francisco, USA Preservation of Myocardial Contractility during Acute Hypoxia with OMX—A Novel Oxygen Delivery Biotherapeutic
Thursday, March 09 \| 2:30PM - 4:30PM Workshop 2: Hypoxia and Disease Processes Room: Sea to Sky B Speaker 4 of 7 Sara M. Timpano, University of Guelph, Canada Human Cells Cultured Under Physiological Oxygen Utilize a Different Mode of Translation Initiation, Have Higher Proliferation Rates, Less Oxidized DNA and More Tubular Mitochondria
Thursday, March 09 \| 2:30PM - 4:30PM Workshop 2: Hypoxia and Disease Processes Room: Sea to Sky B Speaker 5 of 7 Norihiko Takeda, University of Tokyo, Japan HIF-1-PDK1 Axis Induced Active Glycolysis Plays an Essential Role in Macrophage Migratory Capacity
Thursday, March 09 \| 2:30PM - 4:30PM Workshop 2: Hypoxia and Disease Processes Room: Sea to Sky B Speaker 6 of 7 Merve Erdem, Uniklinik Aachen, Germany HIF-1alpha in Myeloid Cells Affects Peripheral Lipid Metabolism in Cancer Cachexia
Thursday, March 09 \| 2:30PM - 4:30PM Workshop 2: Hypoxia and Disease Processes Room: Sea to Sky B Speaker 7 of 7 Jamie D. Weyandt, Vanderbilt University Medical Center, USA Loss of Fumarate Hydratase Upregulates Glycolytic Metabolism in a Mouse Renal Carcinoma Cell Line
Thursday, March 09 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Thursday, March 09 \| 5:00PM - 6:45PM O2 Availability and Stress Responses Room: Sea to Sky B Speaker 1 of 4 * Randall S. Johnson, University of Cambridge, UK
Thursday, March 09 \| 5:00PM - 6:45PM O2 Availability and Stress Responses Room: Sea to Sky B Speaker 2 of 4 Constantinos Koumenis, University of Pennsylvania, USA Genome-Wide Analysis of Hypoxic Responses in Cells and Tumors Reveals Novel Splicing Pathways Impacting Macromolecular Synthesis
Thursday, March 09 \| 5:00PM - 6:45PM O2 Availability and Stress Responses Room: Sea to Sky B Speaker 3 of 4 Bradly G. Wouters, University Health Network, Canada ULK1 Regulates Oxygen Metabolism, Hypoxia Tolerance and Is a Therapeutic Target in Pancreatic Cancer
Thursday, March 09 \| 5:00PM - 6:45PM O2 Availability and Stress Responses Room: Sea to Sky B Speaker 4 of 4 Ester M. Hammond, University of Oxford, UK Ribonucleotide Reductase Favors the RRM2B Subunit to Maintain DNA Replication in Hypoxia
Thursday, March 09 \| 5:00PM - 6:45PM Metabolic Vulnerabilities in Cancer This session is from Tumor Metabolism Room: Sea to Sky C Speaker 1 of 4 * Almut Schulze, University of Würzburg/Theodor-Boveri Institute, Germany
Thursday, March 09 \| 5:00PM - 6:45PM Metabolic Vulnerabilities in Cancer This session is from Tumor Metabolism Room: Sea to Sky C Speaker 2 of 4 Eileen P. White, Rutgers University, USA Inhibiting Autophagy as a Cancer Therapy
Thursday, March 09 \| 5:00PM - 6:45PM Metabolic Vulnerabilities in Cancer This session is from Tumor Metabolism Room: Sea to Sky C Speaker 3 of 4 Katya Marjon, Agios Pharmaceuticals, USA Metabolic Collateral Vulnerabilities of MTAP-Deleted Cancers as Therapeutic Opportunities
Thursday, March 09 \| 5:00PM - 6:45PM Metabolic Vulnerabilities in Cancer This session is from Tumor Metabolism Room: Sea to Sky C Speaker 4 of 4 Reuben J. Shaw, The Salk Institute for Biological Studies, USA The AMPK Pathway: Cancer Fighter, Cancer Promoter
Thursday, March 09 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Sea to Sky B
Thursday, March 09 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) This session is from Tumor Metabolism Room: Sea to Sky C
Thursday, March 09 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Sea to Sky A No registration fees are used to fund alcohol served at this function.
Thursday, March 09 \| 8:00PM - 11:00PM Entertainment Room: Sea to Sky A Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, March 09 \| 8:00PM - 11:00PM Cash Bar Room: Sea to Sky A
Friday, March 10 \| 10:24AM - 10:24AM Departure *Session Chair †Invited, not yet responded.