Web Desc
Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease
joint with Type I Interferon: Friend and Foe Alike
Organizer(s): Thirumala-Devi Kanneganti, Vishva M. Dixit and Mohamed Lamkanfi
Date: March 19 - 23, 2017
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by AbbVie Inc., Genentech, Inc. and Merck & Co., Inc.
Summary of Meeting:
Understanding of the signaling mechanisms by which pattern recognition receptors (PRRs) sense microbial infections and cellular stress engage innate immune responses is moving at an unprecedented rate. Developments in the past few years shed new light on how NOD-like receptors and inflammasomes are activated to promote cytokine production and cell death responses in the context of autoimmunity and microbial infection. Other findings clarified how extracellular and intracellular receptors of the Toll-like receptor, PYHIN/IFI, and helicase families respond to infections. In addition, intricate communication between PRRs and microbial commensals has emerged as a critical mechanism controlling immunity, and several fine-tuning mechanisms modulating PRR-induced immune responses have been discovered. Finally, a wealth of clinical information supporting the key roles of PRRs not only in host-microbe interactions, but also chronic autoinflammatory and autoimmune diseases in patients has emerged. This has spurred important translational medicine efforts to bring new therapies and diagnostics to the clinic. This conference unites an international group of academic and industry immunologists and microbiologists who study basic mechanisms of PRR signaling and their interaction with microbes in inflammatory disease models with clinicians and geneticists addressing the etiology of autoinflammatory and autoimmune diseases in patients. Gathering experts from these disparate research communities offers a unique opportunity to discuss new concepts of innate immune signaling and formulate novel approaches for modulating pathological mechanisms in human inflammatory diseases.
Scholarship Deadline: November 17 2016
Discounted Abstract Deadline: November 17 2016
Abstract Deadline: December 20 2016
Discounted Registration Deadline: January 19 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AbbVie Inc.Genentech, Inc.Merck & Co., Inc.
We gratefully acknowledge additional support for this conference from:
Adipogen InternationalCEDARLANE
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Arthritis Research & Therapy (published by BioMed Central Ltd)
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Van Horne Foyer


Sunday, March 19 | 6:00PM - 8:00PM
Welcome Mixer
Room: Van Horne Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 20 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Monday, March 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 1 of 5
* Alan Sher, NIAID, National Institutes of Health, USA

Monday, March 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 2 of 5
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

Monday, March 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 3 of 5
Anne O'Garra, Francis Crick Institute, UK
Type I IFN Regulation of Cytokine Networks and Consequences for Infection

Monday, March 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 4 of 5
Daniel Kastner, National Institutes of Health, USA
PRR Signaling and Inflammatory Disease

Monday, March 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B


Coffee Break

Monday, March 20 | 9:50AM - 12:15PM
Nucleic Acid Recognition Pathways Regulating Type I IFN Indu
ction (Joint)

Room: Van Horne A/B

Speaker 1 of 4
* Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Cytosolic Recognition of DNA through cGAS/STING Pathway

Monday, March 20 | 9:50AM - 12:15PM
Nucleic Acid Recognition Pathways Regulating Type I IFN Indu
ction (Joint)

Room: Van Horne A/B

Speaker 2 of 4
Sun Hur, Harvard Medical School, USA
Cytosolic Sensing of Viral RNA by the RIG-I-Like Receptors

Monday, March 20 | 9:50AM - 12:15PM
Nucleic Acid Recognition Pathways Regulating Type I IFN Indu
ction (Joint)

Room: Van Horne A/B

Speaker 3 of 4
Gregory M. Barton, University of California, Berkeley, USA
Endosomal Recognition of Self-Nucleic Acids

Monday, March 20 | 9:50AM - 12:15PM
Nucleic Acid Recognition Pathways Regulating Type I IFN Indu
ction (Joint)

Room: Van Horne A/B

Speaker 4 of 4
Vishva M. Dixit, Genentech, Inc., USA
Inflammasome Signaling

Monday, March 20 | 12:15PM - 2:30PM
On Own for Lunch


Monday, March 20 | 12:15PM - 1:00PM
Poster Setup
Room: Mezzanine 2


Monday, March 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 1 of 10
* Eicke Latz, University of Bonn, Germany

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 2 of 10
* Fayyaz Sutterwala, Cedars-Sinai Medical Center, USA

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 3 of 10
Sreya Ghosh, University of Massachusetts Medical School, USA
The PYHIN Protein IFI205 Regulates Immune Signaling by Controlling Expression of the Inflammasome Adaptor ASC

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 4 of 10
Mena Abdel-Nour, University of Toronto, Canada
The eIF2 alpha Kinase HRI Senses Protein Aggregation and Facilitates Signaling of Innate Immune Receptors

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 5 of 10
José Santos, University of Basel, Switzerland
Novel GBP-Dependent Mechanisms of Inflammasome Activation

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 6 of 10
Matthew James George Eldridge, Imperial College London, UK
The Atypical Ubiquitin E2 Conjugase UBE2L3 is an Indirect Caspase-1 Target and controls IL-1Beta Secretion by Inflammasomes

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 7 of 10
Nidhi Jain, Cedars-Sinai Medical Center, USA
NLRP12 Mutation Causes C57BL/6J Strain-Specific Defect in Neutrophil Recruitment

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 8 of 10
Nina Van Opdenbosch, Janssen Pharmaceutica, Belgium
Defective Caspase-1 Recruitment Licenses ASC Specks to Engage Non-Inflammatory Caspase-8-Driven Apoptosis in Macrophages and Intestinal Epithelial Cells

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 9 of 10
Charlotte Macleod, University of Cambridge, UK
Determining the Stoichiometry of the TLR-4 Adaptor Protein Mal/TIRAP using TIRF Microscopy

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 10 of 10
Scott W. Canna, Children's Hospital of Pittsburgh, University of Pittsburgh, USA
Chronic IL-18 of Diverse Origins Defines and Drives the Hyperinflammatory State Known as Macrophage Activation Syndrome

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
This session is from Type I Interferon
Room: Van Horne C

Speaker 1 of 10
* Paul J. Hertzog, Hudson Institute of Medical Research, Australia


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
This session is from Type I Interferon
Room: Van Horne C

Speaker 2 of 10
* Dusan Bogunovic, Icahn School of Medicine at Mount Sinai, USA


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
This session is from Type I Interferon
Room: Van Horne C

Speaker 3 of 10
John Ty Crowl, University of Washington, USA
Loss of Sumoylation Triggers a Spontaneous Type I Interferon Response Independent of Cytosolic Nucleic Acid Sensing Pathways


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
This session is from Type I Interferon
Room: Van Horne C

Speaker 4 of 10
Martin R. Jakobsen, department of biomedicine, Denmark
IFI16 Dictates DNA Sensing in Human Macrophages by Promoting Production and Function of cGAMP


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
This session is from Type I Interferon
Room: Van Horne C

Speaker 5 of 10
Stefanie Luecke, Aarhus University, Denmark
Length-Dependent Sensing of Low-Abundance dsDNA by cGAS


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
This session is from Type I Interferon
Room: Van Horne C

Speaker 6 of 10
Jennifer Lumb, Stanford University, USA
Unbiased Haploid Genetic Screen Uncovers a Novel RNA Binding Immune Regulator


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
This session is from Type I Interferon
Room: Van Horne C

Speaker 7 of 10
Nathalie M. Grandvaux, Université de Montréal, Canada
Characterization of a Delayed Transcriptional Program Induced in Response to the Synergistic Action of IFNBeta+TNFalpha Reveals Novel STAT2 and IRF9-Dependent Pathways


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
This session is from Type I Interferon
Room: Van Horne C

Speaker 8 of 10
Jennie B. Altman, Icahn School of Medicine at Mount Sinai, USA
Non-Canonical Type I IFN Signaling in ISG15-/- and USP18-/- Cells


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
This session is from Type I Interferon
Room: Van Horne C

Speaker 9 of 10
Antje Blumenthal, University of Queensland, Australia
Spatiotemporal Regulation of TLR4 Signaling and Promotion of Type I IFN Responses by the RP105-PI3K p110delta Innate Immune Signaling Axis


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
This session is from Type I Interferon
Room: Van Horne C

Speaker 10 of 10
Philippe D. Pierre, Centre d'Immunologie Marseille-Luminy, CIML, France
Ppp1r15a/GADD34 Controls Heterogeneity of Type-I Interferon Production in Response to dsRNA


Monday, March 20 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Monday, March 20 | 5:00PM - 7:00PM
Nucleic Acids in TLR and NLR Signaling
Room: Van Horne A/B

Speaker 1 of 5
* Mohamed Lamkanfi, Ghent University, Belgium

Monday, March 20 | 5:00PM - 7:00PM
Nucleic Acids in TLR and NLR Signaling
Room: Van Horne A/B

Speaker 2 of 5
Jonathan C. Kagan, Boston Children's Hospital, USA
Initiation and Regulation of Innate Immune Signal Transduction

Monday, March 20 | 5:00PM - 7:00PM
Nucleic Acids in TLR and NLR Signaling
Room: Van Horne A/B

Speaker 3 of 5
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Novel Regulators of PRR-Driven Transcriptional Responses

Monday, March 20 | 5:00PM - 7:00PM
Nucleic Acids in TLR and NLR Signaling
Room: Van Horne A/B

Speaker 4 of 5
Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Inflammasomes and Pathogen Sensing

Monday, March 20 | 5:00PM - 7:00PM
Nucleic Acids in TLR and NLR Signaling
Room: Van Horne A/B

Speaker 5 of 5
Osamu Takeuchi, Kyoto University, Japan
Short Talk: Spatiotemporal Regulation of Inflammatory mRNAs in Innate Immune Responses

Monday, March 20 | 5:00PM - 7:00PM
Mendelian Interferonopathies and IFN-Deficiencies
This session is from Type I Interferon
Room: Van Horne C

Speaker 1 of 5
* Virginia Pascual, Cornell University, USA


Monday, March 20 | 5:00PM - 7:00PM
Mendelian Interferonopathies and IFN-Deficiencies
This session is from Type I Interferon
Room: Van Horne C

Speaker 2 of 5
Dusan Bogunovic, Icahn School of Medicine at Mount Sinai, USA
Loss of Type I Interferon Negative Regulation in Humans


Monday, March 20 | 5:00PM - 7:00PM
Mendelian Interferonopathies and IFN-Deficiencies
This session is from Type I Interferon
Room: Van Horne C

Speaker 3 of 5
Min Ae Lee-Kirsch, Technische Universität Dresden, Germany
Defective Intracellular Nucleic Acid Waste Management in Type 1 Interferon-Driven Autoinflammation and Autoimmunity


Monday, March 20 | 5:00PM - 7:00PM
Mendelian Interferonopathies and IFN-Deficiencies
This session is from Type I Interferon
Room: Van Horne C

Speaker 4 of 5
Raphaela Theresia Goldbach-Mansky, NIAID, National Institutes of Health, USA
Novel Insights into the Pathogenesis and Treatment Approaches of the Type I-IFN-Mediated Autoinflammatory Diseases, CANDLE and SAVI


Monday, March 20 | 5:00PM - 7:00PM
Mendelian Interferonopathies and IFN-Deficiencies
This session is from Type I Interferon
Room: Van Horne C

Speaker 5 of 5
Joaquín M. Espinosa, Linda Crnic Institute for Down Syndrome, USA
Short Talk: Trisomy 21 Consistently Activates the Interferon Response: Understanding Down Syndrome as an Interferonopathy


Monday, March 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Monday, March 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Mezzanine 2


Tuesday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
Room: Van Horne A/B

Speaker 1 of 8
* Vishva M. Dixit, Genentech, Inc., USA

Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
Room: Van Horne A/B

Speaker 2 of 8
Fayyaz Sutterwala, Cedars-Sinai Medical Center, USA
Cardiolipin Promotes Mitochondrial Localization of NLRP3 and Caspase-1

Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
Room: Van Horne A/B

Speaker 3 of 8
Mohamed Lamkanfi, Ghent University, Belgium
Inflammasome Regulation in Auto-Inflammation

Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
Room: Van Horne A/B


Coffee Break

Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
Room: Van Horne A/B

Speaker 5 of 8
Kim Newton, Genentech, Inc., USA
Regulation of Inflammation and Cell Death by RIPK1

Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
Room: Van Horne A/B

Speaker 6 of 8
Feng Shao, National Institute of Biological Sciences, China
Pyroptosis in Anti-Bacterial Immunity: Sensing & Execution

Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
Room: Van Horne A/B

Speaker 7 of 8
Bharat Behl, University of Connecticut Health Center, USA
Short Talk: Molecular Determinants of Noncanonical Inflammasome Activation by LPS

Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
Room: Van Horne A/B

Speaker 8 of 8
Olaf Groß, Universitätsklinikum Freiburg, Germany
Short Talk: Caspase-1 Mutant Mouse Reveals a Central Role of Caspase-1 Protease Activity and GSDMD in Fate Decisions After Inflammasome Activation

Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
This session is from Type I Interferon
Room: Van Horne C

Speaker 1 of 8
* Adolfo García-Sastre, Mount Sinai School of Medicine, USA


Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
This session is from Type I Interferon
Room: Van Horne C

Speaker 2 of 8
Ana Fernandez-Sesma, Icahn School of Medicine at Mount Sinai, USA
Modulation of Innate Immunity by Dengue Virus: Feeling the STING


Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
This session is from Type I Interferon
Room: Van Horne C

Speaker 3 of 8
Andreas Wack, Francis Crick Institute, UK
Unique and Overlapping Roles of Type I and Type III Interferons in Influenza Infection


Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
This session is from Type I Interferon
Room: Van Horne C


Coffee Break


Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
This session is from Type I Interferon
Room: Van Horne C

Speaker 5 of 8
John W. Schoggins, University of Texas Southwestern Medical Center, USA
Cell Intrinsic Modulation of Viral and Bacterial Infection by IFN-Stimulated Genes


Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
This session is from Type I Interferon
Room: Van Horne C

Speaker 6 of 8
Thomas J. Braciale, University of Virginia, USA
Innate Immune Control of Respiratory Virus Infection


Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
This session is from Type I Interferon
Room: Van Horne C

Speaker 7 of 8
Gaya K. Amarasinghe, Washington University in St. Louis, USA
Short Talk: Control of Type I IFN Signaling in Negative Sense RNA Viruses


Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
This session is from Type I Interferon
Room: Van Horne C

Speaker 8 of 8
Jason Waithman, Telethon Kids Institute, Australia
Short Talk: IFNalpha Subtypes Drive Distinct Anti-Cancer Activities


Tuesday, March 21 | 11:15AM - 2:30PM
On Own for Lunch


Tuesday, March 21 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Tuesday, March 21 | 11:15AM - 12:15PM
Meet the Editors
Room: Van Horne A/B

Speaker 1 of 1
* Teodoro Pulvirenti, Journal of Experimental Medicine, USA

Tuesday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 1 of 9
* Dmitry M. Shayakhmetov, Emory University, USA

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 2 of 9
* Denise M. Monack, Stanford University, USA

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 3 of 9
Tsan Sam Xiao, Case Western Reserve University, USA
Structures of GSDMD C-Terminal Domain Suggest Mechanisms of Autoinhibition

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 4 of 9
Igor E. Brodsky, University of Pennsylvania, USA
Role of Caspase-8 Enzymatic Activity in Control of TLR-Induced Macrophage Gene Expression

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 5 of 9
Damien Arnoult, Hopital Paul Brousse, France
The Golgi Apparatus Acts as a Platform for TBK1 Activation After Viral RNA Sensing

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 6 of 9
Randilea Nichols, University of California, Los Angeles, USA
NLRC4 Inflammasome Activation in Neutrophils is Sufficient to Cause Systemic Inflammatory Disease

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 7 of 9
Rosalie Heilig, University of Basel, Switzerland
The Role of Gasdermin D in IL-1Beta Release

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 8 of 9
Cindy Chiang, University of Chicago, USA
The Human Papillomavirus E6 Oncoprotein Inhibits TRIM25- and RIG-I-Mediated Innate Immune Signaling

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 9 of 9
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Innate Immune Sensing of Cytosolic Chromatin Fragments through cGAS Promotes Cellular Senescence

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 1 of 9
* Thomas J. Braciale, University of Virginia, USA


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 2 of 9
* Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 3 of 9
Charles S. Dela Cruz, Yale University, USA
Chitinase-Like Protein Chi3l1 Modulates Type I Interferon Response through TLR9-AP3-IRF7 Axis during Streptococcus Pneumoniae Lung Infection


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 4 of 9
Ren Sun, University of California, Los Angeles, USA
Genome-Wide Identification of Anti-Interferon Functions in Influenza A Virus


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 5 of 9
Lindsey Cook, Washington University in St. Louis, USA
Differential Roles of Type I Interferons in Chikungunya Virus Infection


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 6 of 9
Bastian Opitz, Charité University Medicine Berlin, Germany
A Common Loss-of-Function Variant of STING Affects cGAS-Dependent Antibacterial Defense


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 7 of 9
Laura Sinigaglia, Institut Pasteur, France
Transfer of Yellow Fever Virus RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Interferon Production


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 8 of 9
Nick Parekh, Penn State College of Medicine, USA
cGAS Mediates a Protective Local Response to Dermal Vaccinia Infection Independent of Control of Virus Replication


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 9 of 9
Susan Pereira Ribeiro, Case Western Reserve University, USA
Different Interferon Signatures Characterize Two Subclasses of Immune Non-responder Subjects


Tuesday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, March 21 | 5:00PM - 7:00PM
Interfering with Pathogenic TLR and NLR Signaling
Room: Van Horne A/B

Speaker 1 of 5
* Gabriel Nuñez, University of Michigan, USA

Tuesday, March 21 | 5:00PM - 7:00PM
Interfering with Pathogenic TLR and NLR Signaling
Room: Van Horne A/B

Speaker 2 of 5
Dana Philpott, University of Toronto, Canada
Nod2 Signaling

Tuesday, March 21 | 5:00PM - 7:00PM
Interfering with Pathogenic TLR and NLR Signaling
Room: Van Horne A/B

Speaker 3 of 5
Dmitry M. Shayakhmetov, Emory University, USA
Non-canonical Regulated Necrotic Death and Sensing Danger

Tuesday, March 21 | 5:00PM - 7:00PM
Interfering with Pathogenic TLR and NLR Signaling
Room: Van Horne A/B

Speaker 4 of 5
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Intracellular Innate Immune Receptors: Regulators of Inflammation, Cancer and Immunity

Tuesday, March 21 | 5:00PM - 7:00PM
Interfering with Pathogenic TLR and NLR Signaling
Room: Van Horne A/B

Speaker 5 of 5
Vikram R. Rao, Pfizer, USA
Short Talk: IRAK4 Kinase Inhibitors: Emerging Biology and Therapeutic Implications

Tuesday, March 21 | 5:00PM - 7:00PM
Type I IFN Regulation of Viral Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 1 of 5
* Andreas Wack, Francis Crick Institute, UK


Tuesday, March 21 | 5:00PM - 7:00PM
Type I IFN Regulation of Viral Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 2 of 5
Netanya Sandler Utay, University of Texas Health Science Center at Houston, USA
Type I Interferons: Barrier or Pathway to HIV Disease?


Tuesday, March 21 | 5:00PM - 7:00PM
Type I IFN Regulation of Viral Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 3 of 5
Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Regulation of Influenza Virus Sensing and Antiviral Responses by Host and Virus Factors


Tuesday, March 21 | 5:00PM - 7:00PM
Type I IFN Regulation of Viral Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 4 of 5
Andreas Pichlmair, Max-Planck Institute of Biochemistry, Germany
Interactions of Cellular Proteins with Viral Nucleic Acids


Tuesday, March 21 | 5:00PM - 7:00PM
Type I IFN Regulation of Viral Infection
This session is from Type I Interferon
Room: Van Horne C

Speaker 5 of 5
Ricardo Rajsbaum, University of Texas Medical Branch, USA
Short Talk: Friend and Foe in the Regulation of IFN Pathways: Pro-Viral and Anti-Viral Functions of the Host E3-Ubiquitin Ligase TRIM6


Tuesday, March 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Tuesday, March 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Mezzanine 2


Wednesday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
Room: Van Horne A/B

Speaker 1 of 9
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
Room: Van Horne A/B

Speaker 2 of 9
Russell E. Vance, University of California, Berkeley, USA
Activation of Inflammasomes by Bacterial Pathogens

Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
Room: Van Horne A/B

Speaker 3 of 9
Amal Amer, Ohio State University, USA
Unconventional Functions of Inflammasomes

Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
Room: Van Horne A/B


Coffee Break

Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
Room: Van Horne A/B

Speaker 5 of 9
Denise M. Monack, Stanford University, USA
Inflammasomes and Bacterial Infections

Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
Room: Van Horne A/B

Speaker 6 of 9
Christian Holm, Aarhus University, Denmark
Short Talk: Nitro-Fatty Acids Can Suppress STING Signaling

Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
Room: Van Horne A/B

Speaker 7 of 9
Peng Li, National Institute of Biological Sciences, China
Short Talk: Ubiquitination and Degradation of GBPs by Shigella Ipha9.8 Effector to Suppress Host Defenses

Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
Room: Van Horne A/B

Speaker 8 of 9
Valesca Lindenberg, Institute of Medical Microbiology and Hospital Hygiene, Germany
Short Talk: Extensive Characterization of mGBPs Localization Chlamydia trachomatis Infection

Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
Room: Van Horne A/B

Speaker 9 of 9
Katelyn Susanne Burleigh, University of Washington, USA
Short Talk: Uncovering the Mechanism of E1A Antagonism of the cGAS-STING Pathway

Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
This session is from Type I Interferon
Room: Van Horne C

Speaker 1 of 8
* Alan Sher, NIAID, National Institutes of Health, USA


Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
This session is from Type I Interferon
Room: Van Horne C

Speaker 2 of 8
Thomas J. Scriba, University of Cape Town, South Africa
IFN Signatures that Predict Human Tuberculosis


Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
This session is from Type I Interferon
Room: Van Horne C

Speaker 3 of 8
Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA
The Dichotomy between Interleukin 1 and Type I Interferon during Mycobacterium Tuberculosis Infection Exposes Distinct and Opposing Classes of Inflammation


Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
This session is from Type I Interferon
Room: Van Horne C


Coffee Break


Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
This session is from Type I Interferon
Room: Van Horne C

Speaker 5 of 8
Craig R. Roy, Yale University School of Medicine, USA
Modulation of Type I Interferon Production during Infection by Vacuolar Pathogens


Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
This session is from Type I Interferon
Room: Van Horne C

Speaker 6 of 8
Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Human Dendritic Cell Subsets Differentially Respond to Vaccines


Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
This session is from Type I Interferon
Room: Van Horne C

Speaker 7 of 8
Terje Espevik, Norwegian University of Science and Technology, Norway
Short Talk: CD150 Positively Regulates TRAM Recruitment to E.coli Phagosomes and Type I IFN Secretion


Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
This session is from Type I Interferon
Room: Van Horne C

Speaker 8 of 8
Beiyun Caitlin Liu, Tufts University, USA
Short Talk: Host-Intrinsic Interferon Signaling Licenses GBP-Mediated Attack on Cytosolic Bacteria


Wednesday, March 22 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, March 22 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Wednesday, March 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Wednesday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, March 22 | 5:00PM - 7:00PM
Inflammasome and NF-kB Regulatory Mechanisms
Room: Van Horne A/B

Speaker 1 of 5
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

Wednesday, March 22 | 5:00PM - 7:00PM
Inflammasome and NF-kB Regulatory Mechanisms
Room: Van Horne A/B

Speaker 2 of 5
Christian Stehlik, Cedars-Sinai Medical Center, USA
Inflammasome Inhibition

Wednesday, March 22 | 5:00PM - 7:00PM
Inflammasome and NF-kB Regulatory Mechanisms
Room: Van Horne A/B

Speaker 3 of 5
Eicke Latz, University of Bonn, Germany
Inflammasomes in Health and Disease

Wednesday, March 22 | 5:00PM - 7:00PM
Inflammasome and NF-kB Regulatory Mechanisms
Room: Van Horne A/B

Speaker 4 of 5
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Metabolic Reprogramming in Innate Immunity and Inflammation

Wednesday, March 22 | 5:00PM - 7:00PM
Inflammasome and NF-kB Regulatory Mechanisms
Room: Van Horne A/B

Speaker 5 of 5
Ali A. Zarrin, Genentech, Inc., USA
Short Talk: TPL2 Kinase Activates MEK-1/2 and/or MEK-3/6 to Regulate Inflammatory Pathways in Myeloid Cells

Wednesday, March 22 | 5:00PM - 7:00PM
Role of Type I IFN in Complex Autoimmunity
This session is from Type I Interferon
Room: Van Horne C

Speaker 1 of 4
* Virginia Pascual, Cornell University, USA
Pathogenic Functions of Type I IFN in SLE


Wednesday, March 22 | 5:00PM - 7:00PM
Role of Type I IFN in Complex Autoimmunity
This session is from Type I Interferon
Room: Van Horne C

Speaker 2 of 4
* Richard M. Siegel, NIAMS, National Institutes of Health, USA
Interferon, Anti-Interferon Antibodies and NK Cells in Systemic Autoimmunity


Wednesday, March 22 | 5:00PM - 7:00PM
Role of Type I IFN in Complex Autoimmunity
This session is from Type I Interferon
Room: Van Horne C

Speaker 3 of 4
Robert C. Axtell, Oklahoma Medical Research Foundation, USA
Immunological Heterogeneity in Neurological Autoimmunity: Lessons from Studying Type I Interferon Responses


Wednesday, March 22 | 5:00PM - 7:00PM
Role of Type I IFN in Complex Autoimmunity
This session is from Type I Interferon
Room: Van Horne C

Speaker 4 of 4
Mari L. Shinohara, Duke University, USA
Short Talk: Type-I Interferons and the NLRP3 Inflammasome in CNS Autoimmunity


Wednesday, March 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Wednesday, March 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Mezzanine 2


Thursday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
Room: Van Horne A/B

Speaker 1 of 9
* Mihai G. Netea, Radboud University, Netherlands

Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
Room: Van Horne A/B

Speaker 2 of 9
Daniel Graham, Massachusetts General Hospital, USA
Host Genetics and Microbe Interactions in Human Disease

Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
Room: Van Horne A/B

Speaker 3 of 9
Kathy D. McCoy, University of Calgary, Canada
Intestinal Commensal Microbiota and Education of the Innate Immune System

Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
Room: Van Horne A/B


Coffee Break

Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
Room: Van Horne A/B

Speaker 5 of 9
Gabriel Nuñez, University of Michigan, USA
Control of Pathogen Colonization by Host Immunity and the Microbiota in the Gut

Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
Room: Van Horne A/B

Speaker 6 of 9
Andrew T. Gewirtz, Georgia State University / Frontiers, USA
Microbial-Mediated Protection from Infectious Disease

Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
Room: Van Horne A/B

Speaker 7 of 9
Prosper N. Boyaka, Ohio State University, USA
Regulation of Mucosal Immunity by Toxins and Microbiota

Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
Room: Van Horne A/B

Speaker 8 of 9
Grace Yi Chen, University of Michigan, USA
Short Talk: NLRP6 Limits Colonization of Akkermansia to Protect Against the Development of Colitis and Colon Tumorigenesis

Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
Room: Van Horne A/B

Speaker 9 of 9
Felix Yarovinsky, University of Rochester Medical Center, USA
Short Talk: Loss of Paneth Cell Autophagy Leads to Catastrophic Susceptibility to Acute Gastrointestinal Inflammation

Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
This session is from Type I Interferon
Room: Van Horne C

Speaker 1 of 8
* Anne O'Garra, Francis Crick Institute, UK


Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
This session is from Type I Interferon
Room: Van Horne C

Speaker 2 of 8
Jae U. Jung, Keck School of Medicine of University of Southern California, USA
TRIM-Mediated Control of Type I IFN Pathway


Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
This session is from Type I Interferon
Room: Van Horne C

Speaker 3 of 8
Marco Colonna, Washington University School of Medicine, USA
Targeting Type I IFN Activity through Plasmacytoid DC


Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
This session is from Type I Interferon
Room: Van Horne C


Coffee Break


Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
This session is from Type I Interferon
Room: Van Horne C

Speaker 5 of 8
Laurel L. Lenz, University of Colorado, USA
Role of Type I - Type II IFN Crosstalk in Macrophage Effector Function


Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
This session is from Type I Interferon
Room: Van Horne C

Speaker 6 of 8
Gideon Schreiber, Weizmann Institute, Israel
The Molecular Basis for Differential Activity of Type I Interferons


Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
This session is from Type I Interferon
Room: Van Horne C

Speaker 7 of 8
Paul J. Hertzog, Hudson Institute of Medical Research, Australia
Short Talk: Systems Biology of Type I Interferon Responses


Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
This session is from Type I Interferon
Room: Van Horne C

Speaker 8 of 8
Ronald L. Rabin, US Food and Drug Administration, USA
Short Talk: A Potential Modulatory Role for IFNalpha1 Dependent on its Low Affinity for IFNAR2


Thursday, March 23 | 11:45AM - 5:00PM
On Own for Lunch


Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 1 of 8
* Amal Amer, Ohio State University, USA

Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 2 of 8
* Dana Philpott, University of Toronto, Canada

Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 3 of 8
Eric P. Hanson, National Institutes of Health, USA
A Novel NEMO Isoform Mediates Enhanced Antiviral Activity and Autoinflammatory Disease via Stabilization of IKKepsilon

Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 4 of 8
Kiva V. Brennan, Trinity College Dublin, Ireland
Designing Vaccines for the Paediatric Population; Potential for Cytosolic Nucleic Acids as Vaccine Adjuvants

Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 5 of 8
Nesrin Ozoren, Bogazici University, Turkey
ASC Specks as Vaccine Technology

Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 6 of 8
Jingjin Ding, National Institute of Biological Sciences, China
LPS Binding to Caspase-11/4/5 Triggers Pyroptosis by Releasing the Pore-Forming Activity of GSDMD

Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 7 of 8
Orna Rabinovich-Ernst, NIAID, National Institutes of Health, USA
An Arrayed Genome-Wide RNAi Screen for the Discovery of Novel Inflammasome Regulators

Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
Room: Van Horne A/B

Speaker 8 of 8
Thomas A. Kufer, University of Hohenheim, Germany
Roles of NLRP10 in Innate and Adaptive Immunity

Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
This session is from Type I Interferon
Room: Van Horne C

Speaker 1 of 9
* Marco Colonna, Washington University School of Medicine, USA


Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
This session is from Type I Interferon
Room: Van Horne C

Speaker 2 of 9
* Raphaela Theresia Goldbach-Mansky, NIAID, National Institutes of Health, USA


Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
This session is from Type I Interferon
Room: Van Horne C

Speaker 3 of 9
Kebin Liu, Medical College of Georgia, USA
Jak-STAT-Mediated Chronic Inflammation Impairs Cytotoxic T Lymphocyte Activation to Decrease Anti-PD-1 Immunotherapy Efficacy in Pancreatic Cancer


Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
This session is from Type I Interferon
Room: Van Horne C

Speaker 4 of 9
Jacquelyn Gorman, Seattle Children's Research Institute, USA
The IFIH1A946T Coding Variant Mediates an Interferon Program that Limits Viral Infection but Increases the Risk for Autoimmunity


Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
This session is from Type I Interferon
Room: Van Horne C

Speaker 5 of 9
Mark E. Kleinman, University of Kentucky, USA
Epigenetic Regulation of Type I IFN Response in Age-Related Macular Degeneration


Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
This session is from Type I Interferon
Room: Van Horne C

Speaker 6 of 9
Elisaveta Voynova, Medimmune, USA
Blockade of Critical Immune Regulators Results in Different Roads to Pathogenesis in Primary Sjögren’s Syndrome


Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
This session is from Type I Interferon
Room: Van Horne C

Speaker 7 of 9
Mona Motwani, University of Massachusetts, USA
The cGAS-STING Pathway Restrains Systemic Autoimmunity


Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
This session is from Type I Interferon
Room: Van Horne C

Speaker 8 of 9
Simone Caielli, Baylor Institute for Immunology Research, USA
Oxidized Mitochondrial DNA is a Powerful Activator of Human pDCs and Induces a Lupus-Specific CD4 T Cell Phenotype


Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
This session is from Type I Interferon
Room: Van Horne C

Speaker 9 of 9
Stephen Rubino, Brigham and Women's Hospital, USA
Activated Microglia Induce Type 1-interferon Dependent Neurodegeneration


Thursday, March 23 | 4:00PM - 4:30PM
Navigating the Peer Review Process
Room: Van Horne A/B
Information will be provided about how to understand the NIH peer review system with a focus on recent changes to the review process. Anyone interested in learning more about preparing an NIH grant application and tips about the review of grant applications is welcome to attend.
Speaker 1 of 1
* Tina M. McIntyre, National Institutes of Health, USA

Thursday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, March 23 | 5:00PM - 6:45PM
Innate Immune Receptors and Metabolism
Room: Van Horne A/B

Speaker 1 of 5
* Prosper N. Boyaka, Ohio State University, USA

Thursday, March 23 | 5:00PM - 6:45PM
Innate Immune Receptors and Metabolism
Room: Van Horne A/B

Speaker 2 of 5
Marcia A. Munoz, Garvan Institute of Medical Research, Australia
Short Talk: Defective Protein Prenylation Is a Diagnostic Biomarker for Mevalonate Kinase Deficiency

Thursday, March 23 | 5:00PM - 6:45PM
Innate Immune Receptors and Metabolism
Room: Van Horne A/B

Speaker 3 of 5
Je-Wook Yu, Yonsei University College of Medicine, South Korea
Short Talk: 25-Hydroxycholesterol Contributes to Cerebral Inflammation of X-Linked Adrenoleukodystrophy (X-ALD) through Activation of the NLRP3 Inflammasome

Thursday, March 23 | 5:00PM - 6:45PM
Innate Immune Receptors and Metabolism
Room: Van Horne A/B

Speaker 4 of 5
Vishwa Deep Dixit, Yale University, USA
Metabolic Control of Inflammasomes

Thursday, March 23 | 5:00PM - 6:45PM
Innate Immune Receptors and Metabolism
Room: Van Horne A/B

Speaker 5 of 5
Mihai G. Netea, Radboud University, Netherlands
Metabolic Basis for Trained Innate Immunity

Thursday, March 23 | 5:00PM - 6:45PM
Tailoring Type I IFN Interventions to Achieve Cure
This session is from Type I Interferon
Room: Van Horne C

Speaker 1 of 4
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA


Thursday, March 23 | 5:00PM - 6:45PM
Tailoring Type I IFN Interventions to Achieve Cure
This session is from Type I Interferon
Room: Van Horne C

Speaker 2 of 4
Geraldine P. Grouard-Vogel, Neovacs, France
Overexpression of IFNalpha and Derived Diseases: Innovative Approach with a Therapeutic Vaccine IFNalpha Kinoid


Thursday, March 23 | 5:00PM - 6:45PM
Tailoring Type I IFN Interventions to Achieve Cure
This session is from Type I Interferon
Room: Van Horne C

Speaker 3 of 4
Gary P. Sims, MedImmune Inc, USA
Novel Pathogenic Role for IgE in SLE, and Pharmacological Blockade of Type I IFN Receptor in Patients


Thursday, March 23 | 5:00PM - 6:45PM
Tailoring Type I IFN Interventions to Achieve Cure
This session is from Type I Interferon
Room: Van Horne C

Speaker 4 of 4
John J. O'Shea, NIAMS, National Institutes of Health, USA
Targeting Type I IFN Signaling Pathways


Thursday, March 23 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Van Horne A/B


Thursday, March 23 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions
This session is from Type I Interferon
Room: Van Horne C

Speaker 1 of 1
* Alan Sher, NIAID, National Institutes of Health, USA


Thursday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Thursday, March 23 | 8:00PM - 11:00PM
Entertainment
Room: Mezzanine 2
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 23 | 8:00PM - 11:00PM
Cash Bar
Room: Mezzanine 2


Friday, March 24 | 10:25AM - 10:25AM
Departure


*Session Chair.