Web Desc
Type I Interferon: Friend and Foe Alike
joint with Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease
Organizer(s): Alan Sher, Virginia Pascual, Adolfo García-Sastre and Anne O'Garra
Date: March 19 - 23, 2017
Location: Fairmont Banff Springs, Banff, AB, Canada
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
While cytokines play critical roles in host defense and immune homeostasis, they in other settings can be key mediators of inflammatory pathology. This important functional dichotomy is perhaps best exemplified in the diverse activities of Type I interferon(s) in health and disease. Type I IFNs regulate a broad family of genes that either stimulate or inhibit immune function and in so doing have host protective or detrimental effects. Thus, while Type I IFNs are well-known for their anti-viral activity and stimulation of effector T cell responses, they can also promote autoimmune, bacterial and even certain viral diseases. Understanding this contextual dependency is crucial for unraveling the pathogenesis of Type I IFN-dependent diseases and for the design of interferon-based therapies and will be the central focus of the meeting. The conference will open with talks presenting an overview of Type I IFN genes and their regulation, innate recognition mechanisms and signaling pathways for Type I IFN induction and Mendelian-based interferonopathies. Additional sessions will focus on the role of Type I IFN in viral, bacterial and autoimmune diseases. The symposium will conclude with a discussion of the mechanistic and contextual factors that determine the beneficial versus deleterious outcome of Type I IFN induction and how this information can be applied to the development of targeted therapeutic interventions. Because of the timeliness of the topic, the conference should draw a broad audience from the fields of cytokine biology, inflammation, infectious disease and translational medicine and attract a solid industry representation.
Scholarship Deadline: November 17 2016
Discounted Abstract Deadline: November 17 2016
Abstract Deadline: December 20 2016
Discounted Registration Deadline: January 19 2017
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


We gratefully acknowledge additional support for this conference from:
CEDARLANE
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

MedImmune
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Arthritis Research & Therapy (published by BioMed Central Ltd)
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI128981-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Van Horne Foyer


Sunday, March 19 | 6:00PM - 8:00PM
Welcome Mixer
Room: Van Horne Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 20 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Monday, March 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 1 of 5
* Alan Sher, NIAID, National Institutes of Health, USA

Monday, March 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 2 of 5
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

Monday, March 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 3 of 5
Anne O'Garra, Francis Crick Institute, UK
Type I IFN Regulation of Cytokine Networks and Consequences for Infection

Monday, March 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 4 of 5
Daniel Kastner, National Institutes of Health, USA
PRR Signaling and Inflammatory Disease

Monday, March 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B


Coffee Break

Monday, March 20 | 9:50AM - 12:15PM
Nucleic Acid Recognition Pathways Regulating Type I IFN Indu
ction (Joint)

Room: Van Horne A/B

Speaker 1 of 4
* Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Cytosolic Recognition of DNA through cGAS/STING Pathway

Monday, March 20 | 9:50AM - 12:15PM
Nucleic Acid Recognition Pathways Regulating Type I IFN Indu
ction (Joint)

Room: Van Horne A/B

Speaker 2 of 4
Sun Hur, Harvard Medical School, USA
Cytosolic Sensing of Viral RNA by the RIG-I-Like Receptors

Monday, March 20 | 9:50AM - 12:15PM
Nucleic Acid Recognition Pathways Regulating Type I IFN Indu
ction (Joint)

Room: Van Horne A/B

Speaker 3 of 4
Gregory M. Barton, University of California, Berkeley, USA
Endosomal Recognition of Self-Nucleic Acids

Monday, March 20 | 9:50AM - 12:15PM
Nucleic Acid Recognition Pathways Regulating Type I IFN Indu
ction (Joint)

Room: Van Horne A/B

Speaker 4 of 4
Vishva M. Dixit, Genentech, Inc., USA
Inflammasome Signaling

Monday, March 20 | 12:15PM - 2:30PM
On Own for Lunch


Monday, March 20 | 12:15PM - 1:00PM
Poster Setup
Room: Mezzanine 2


Monday, March 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
Room: Van Horne C

Speaker 1 of 10
* Paul J. Hertzog, Hudson Institute of Medical Research, Australia

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
Room: Van Horne C

Speaker 2 of 10
* Dusan Bogunovic, Icahn School of Medicine at Mount Sinai, USA

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
Room: Van Horne C

Speaker 3 of 10
John Ty Crowl, University of Washington, USA
Loss of Sumoylation Triggers a Spontaneous Type I Interferon Response Independent of Cytosolic Nucleic Acid Sensing Pathways

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
Room: Van Horne C

Speaker 4 of 10
Martin R. Jakobsen, department of biomedicine, Denmark
IFI16 Dictates DNA Sensing in Human Macrophages by Promoting Production and Function of cGAMP

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
Room: Van Horne C

Speaker 5 of 10
Stefanie Luecke, Aarhus University, Denmark
Length-Dependent Sensing of Low-Abundance dsDNA by cGAS

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
Room: Van Horne C

Speaker 6 of 10
Jennifer Lumb, Stanford University, USA
Unbiased Haploid Genetic Screen Uncovers a Novel RNA Binding Immune Regulator

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
Room: Van Horne C

Speaker 7 of 10
Nathalie M. Grandvaux, Université de Montréal, Canada
Characterization of a Delayed Transcriptional Program Induced in Response to the Synergistic Action of IFNBeta+TNFalpha Reveals Novel STAT2 and IRF9-Dependent Pathways

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
Room: Van Horne C

Speaker 8 of 10
Jennie B. Altman, Icahn School of Medicine at Mount Sinai, USA
Non-Canonical Type I IFN Signaling in ISG15-/- and USP18-/- Cells

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
Room: Van Horne C

Speaker 9 of 10
Antje Blumenthal, University of Queensland, Australia
Spatiotemporal Regulation of TLR4 Signaling and Promotion of Type I IFN Responses by the RP105-PI3K p110delta Innate Immune Signaling Axis

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Innate Signals for Type I IFN Induction
Room: Van Horne C

Speaker 10 of 10
Philippe D. Pierre, Centre d'Immunologie Marseille-Luminy, CIML, France
Ppp1r15a/GADD34 Controls Heterogeneity of Type-I Interferon Production in Response to dsRNA

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 1 of 10
* Eicke Latz, University of Bonn, Germany


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 2 of 10
* Fayyaz Sutterwala, Cedars-Sinai Medical Center, USA


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 3 of 10
Sreya Ghosh, University of Massachusetts Medical School, USA
The PYHIN Protein IFI205 Regulates Immune Signaling by Controlling Expression of the Inflammasome Adaptor ASC


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 4 of 10
Mena Abdel-Nour, University of Toronto, Canada
The eIF2 alpha Kinase HRI Senses Protein Aggregation and Facilitates Signaling of Innate Immune Receptors


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 5 of 10
José Santos, University of Basel, Switzerland
Novel GBP-Dependent Mechanisms of Inflammasome Activation


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 6 of 10
Matthew James George Eldridge, Imperial College London, UK
The Atypical Ubiquitin E2 Conjugase UBE2L3 is an Indirect Caspase-1 Target and controls IL-1Beta Secretion by Inflammasomes


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 7 of 10
Nidhi Jain, Cedars-Sinai Medical Center, USA
NLRP12 Mutation Causes C57BL/6J Strain-Specific Defect in Neutrophil Recruitment


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 8 of 10
Nina Van Opdenbosch, Janssen Pharmaceutica, Belgium
Defective Caspase-1 Recruitment Licenses ASC Specks to Engage Non-Inflammatory Caspase-8-Driven Apoptosis in Macrophages and Intestinal Epithelial Cells


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 9 of 10
Charlotte Macleod, University of Cambridge, UK
Determining the Stoichiometry of the TLR-4 Adaptor Protein Mal/TIRAP using TIRF Microscopy


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 10 of 10
Scott W. Canna, Children's Hospital of Pittsburgh, University of Pittsburgh, USA
Chronic IL-18 of Diverse Origins Defines and Drives the Hyperinflammatory State Known as Macrophage Activation Syndrome


Monday, March 20 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Monday, March 20 | 5:00PM - 7:00PM
Mendelian Interferonopathies and IFN-Deficiencies
Room: Van Horne C

Speaker 1 of 5
* Virginia Pascual, Cornell University, USA

Monday, March 20 | 5:00PM - 7:00PM
Mendelian Interferonopathies and IFN-Deficiencies
Room: Van Horne C

Speaker 2 of 5
Dusan Bogunovic, Icahn School of Medicine at Mount Sinai, USA
Loss of Type I Interferon Negative Regulation in Humans

Monday, March 20 | 5:00PM - 7:00PM
Mendelian Interferonopathies and IFN-Deficiencies
Room: Van Horne C

Speaker 3 of 5
Min Ae Lee-Kirsch, Technische Universität Dresden, Germany
Defective Intracellular Nucleic Acid Waste Management in Type 1 Interferon-Driven Autoinflammation and Autoimmunity

Monday, March 20 | 5:00PM - 7:00PM
Mendelian Interferonopathies and IFN-Deficiencies
Room: Van Horne C

Speaker 4 of 5
Raphaela Theresia Goldbach-Mansky, NIAID, National Institutes of Health, USA
Novel Insights into the Pathogenesis and Treatment Approaches of the Type I-IFN-Mediated Autoinflammatory Diseases, CANDLE and SAVI

Monday, March 20 | 5:00PM - 7:00PM
Mendelian Interferonopathies and IFN-Deficiencies
Room: Van Horne C

Speaker 5 of 5
Joaquín M. Espinosa, Linda Crnic Institute for Down Syndrome, USA
Short Talk: Trisomy 21 Consistently Activates the Interferon Response: Understanding Down Syndrome as an Interferonopathy

Monday, March 20 | 5:00PM - 7:00PM
Nucleic Acids in TLR and NLR Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 1 of 5
* Mohamed Lamkanfi, Ghent University, Belgium


Monday, March 20 | 5:00PM - 7:00PM
Nucleic Acids in TLR and NLR Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 2 of 5
Jonathan C. Kagan, Boston Children's Hospital, USA
Initiation and Regulation of Innate Immune Signal Transduction


Monday, March 20 | 5:00PM - 7:00PM
Nucleic Acids in TLR and NLR Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 3 of 5
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Novel Regulators of PRR-Driven Transcriptional Responses


Monday, March 20 | 5:00PM - 7:00PM
Nucleic Acids in TLR and NLR Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 4 of 5
Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Inflammasomes and Pathogen Sensing


Monday, March 20 | 5:00PM - 7:00PM
Nucleic Acids in TLR and NLR Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 5 of 5
Osamu Takeuchi, Kyoto University, Japan
Short Talk: Spatiotemporal Regulation of Inflammatory mRNAs in Innate Immune Responses


Monday, March 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Monday, March 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Mezzanine 2


Tuesday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
Room: Van Horne C

Speaker 1 of 8
* Adolfo García-Sastre, Mount Sinai School of Medicine, USA

Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
Room: Van Horne C

Speaker 2 of 8
Ana Fernandez-Sesma, Icahn School of Medicine at Mount Sinai, USA
Modulation of Innate Immunity by Dengue Virus: Feeling the STING

Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
Room: Van Horne C

Speaker 3 of 8
Andreas Wack, Francis Crick Institute, UK
Unique and Overlapping Roles of Type I and Type III Interferons in Influenza Infection

Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
Room: Van Horne C


Coffee Break

Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
Room: Van Horne C

Speaker 5 of 8
John W. Schoggins, University of Texas Southwestern Medical Center, USA
Cell Intrinsic Modulation of Viral and Bacterial Infection by IFN-Stimulated Genes

Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
Room: Van Horne C

Speaker 6 of 8
Thomas J. Braciale, University of Virginia, USA
Innate Immune Control of Respiratory Virus Infection

Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
Room: Van Horne C

Speaker 7 of 8
Gaya K. Amarasinghe, Washington University in St. Louis, USA
Short Talk: Control of Type I IFN Signaling in Negative Sense RNA Viruses

Tuesday, March 21 | 8:00AM - 11:15AM
Type I IFN Regulation of Viral Infection and Cancer
Room: Van Horne C

Speaker 8 of 8
Jason Waithman, Telethon Kids Institute, Australia
Short Talk: IFNalpha Subtypes Drive Distinct Anti-Cancer Activities

Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 1 of 8
* Vishva M. Dixit, Genentech, Inc., USA


Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 2 of 8
Fayyaz Sutterwala, Cedars-Sinai Medical Center, USA
Cardiolipin Promotes Mitochondrial Localization of NLRP3 and Caspase-1


Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 3 of 8
Mohamed Lamkanfi, Ghent University, Belgium
Inflammasome Regulation in Auto-Inflammation


Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
This session is from Innate Immunity
Room: Van Horne A/B


Coffee Break


Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 5 of 8
Kim Newton, Genentech, Inc., USA
Regulation of Inflammation and Cell Death by RIPK1


Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 6 of 8
Feng Shao, National Institute of Biological Sciences, China
Pyroptosis in Anti-Bacterial Immunity: Sensing & Execution


Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 7 of 8
Bharat Behl, University of Connecticut Health Center, USA
Short Talk: Molecular Determinants of Noncanonical Inflammasome Activation by LPS


Tuesday, March 21 | 8:00AM - 11:15AM
Recent Insights in Inflammasome Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 8 of 8
Olaf Groß, Universitätsklinikum Freiburg, Germany
Short Talk: Caspase-1 Mutant Mouse Reveals a Central Role of Caspase-1 Protease Activity and GSDMD in Fate Decisions After Inflammasome Activation


Tuesday, March 21 | 11:15AM - 2:30PM
On Own for Lunch


Tuesday, March 21 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Tuesday, March 21 | 11:15AM - 12:15PM
Meet the Editors
Room: Van Horne A/B

Speaker 1 of 1
* Teodoro Pulvirenti, Journal of Experimental Medicine, USA

Tuesday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
Room: Van Horne C

Speaker 1 of 9
* Thomas J. Braciale, University of Virginia, USA

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
Room: Van Horne C

Speaker 2 of 9
* Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
Room: Van Horne C

Speaker 3 of 9
Charles S. Dela Cruz, Yale University, USA
Chitinase-Like Protein Chi3l1 Modulates Type I Interferon Response through TLR9-AP3-IRF7 Axis during Streptococcus Pneumoniae Lung Infection

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
Room: Van Horne C

Speaker 4 of 9
Ren Sun, University of California, Los Angeles, USA
Genome-Wide Identification of Anti-Interferon Functions in Influenza A Virus

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
Room: Van Horne C

Speaker 5 of 9
Lindsey Cook, Washington University in St. Louis, USA
Differential Roles of Type I Interferons in Chikungunya Virus Infection

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
Room: Van Horne C

Speaker 6 of 9
Bastian Opitz, Charité University Medicine Berlin, Germany
A Common Loss-of-Function Variant of STING Affects cGAS-Dependent Antibacterial Defense

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
Room: Van Horne C

Speaker 7 of 9
Laura Sinigaglia, Institut Pasteur, France
Transfer of Yellow Fever Virus RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Interferon Production

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
Room: Van Horne C

Speaker 8 of 9
Nick Parekh, Penn State College of Medicine, USA
cGAS Mediates a Protective Local Response to Dermal Vaccinia Infection Independent of Control of Virus Replication

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: Role of Type I IFNs in Control and Enhancement o
f Infection
Room: Van Horne C

Speaker 9 of 9
Susan Pereira Ribeiro, Case Western Reserve University, USA
Different Interferon Signatures Characterize Two Subclasses of Immune Non-responder Subjects

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 1 of 9
* Dmitry M. Shayakhmetov, Emory University, USA


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 2 of 9
* Denise M. Monack, Stanford University, USA


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 3 of 9
T. Sam Xiao, Case Western Reserve University, USA
Structures of GSDMD C-Terminal Domain Suggest Mechanisms of Autoinhibition


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 4 of 9
Igor E. Brodsky, University of Pennsylvania, USA
Role of Caspase-8 Enzymatic Activity in Control of TLR-Induced Macrophage Gene Expression


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 5 of 9
Damien Arnoult, Hopital Paul Brousse, France
The Golgi Apparatus Acts as a Platform for TBK1 Activation After Viral RNA Sensing


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 6 of 9
Randilea Nichols, University of California, Los Angeles, USA
NLRC4 Inflammasome Activation in Neutrophils is Sufficient to Cause Systemic Inflammatory Disease


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 7 of 9
Rosalie Heilig, University of Basel, Switzerland
The Role of Gasdermin D in IL-1Beta Release


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 8 of 9
Cindy Chiang, University of Chicago, USA
The Human Papillomavirus E6 Oncoprotein Inhibits TRIM25- and RIG-I-Mediated Innate Immune Signaling


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 9 of 9
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Innate Immune Sensing of Cytosolic Chromatin Fragments through cGAS Promotes Cellular Senescence


Tuesday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, March 21 | 5:00PM - 7:00PM
Type I IFN Regulation of Viral Infection
Room: Van Horne C

Speaker 1 of 5
* Andreas Wack, Francis Crick Institute, UK

Tuesday, March 21 | 5:00PM - 7:00PM
Type I IFN Regulation of Viral Infection
Room: Van Horne C

Speaker 2 of 5
Netanya Sandler Utay, University of Texas Health Science Center at Houston, USA
Type I Interferons: Barrier or Pathway to HIV Disease?

Tuesday, March 21 | 5:00PM - 7:00PM
Type I IFN Regulation of Viral Infection
Room: Van Horne C

Speaker 3 of 5
Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Regulation of Influenza Virus Sensing and Antiviral Responses by Host and Virus Factors

Tuesday, March 21 | 5:00PM - 7:00PM
Type I IFN Regulation of Viral Infection
Room: Van Horne C

Speaker 4 of 5
Andreas Pichlmair, Max-Planck Institute of Biochemistry, Germany
Interactions of Cellular Proteins with Viral Nucleic Acids

Tuesday, March 21 | 5:00PM - 7:00PM
Type I IFN Regulation of Viral Infection
Room: Van Horne C

Speaker 5 of 5
Ricardo Rajsbaum, University of Texas Medical Branch, USA
Short Talk: Friend and Foe in the Regulation of IFN Pathways: Pro-Viral and Anti-Viral Functions of the Host E3-Ubiquitin Ligase TRIM6

Tuesday, March 21 | 5:00PM - 7:00PM
Interfering with Pathogenic TLR and NLR Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 1 of 5
* Gabriel Nuñez, University of Michigan, USA


Tuesday, March 21 | 5:00PM - 7:00PM
Interfering with Pathogenic TLR and NLR Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 2 of 5
Dana Philpott, University of Toronto, Canada
Nod2 Signaling


Tuesday, March 21 | 5:00PM - 7:00PM
Interfering with Pathogenic TLR and NLR Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 3 of 5
Dmitry M. Shayakhmetov, Emory University, USA
Non-canonical Regulated Necrotic Death and Sensing Danger


Tuesday, March 21 | 5:00PM - 7:00PM
Interfering with Pathogenic TLR and NLR Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 4 of 5
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Intracellular Innate Immune Receptors: Regulators of Inflammation, Cancer and Immunity


Tuesday, March 21 | 5:00PM - 7:00PM
Interfering with Pathogenic TLR and NLR Signaling
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 5 of 5
Vikram R. Rao, Pfizer, USA
Short Talk: IRAK4 Kinase Inhibitors: Emerging Biology and Therapeutic Implications


Tuesday, March 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Tuesday, March 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Mezzanine 2


Wednesday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
Room: Van Horne C

Speaker 1 of 8
* Alan Sher, NIAID, National Institutes of Health, USA

Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
Room: Van Horne C

Speaker 2 of 8
Thomas J. Scriba, University of Cape Town, South Africa
IFN Signatures that Predict Human Tuberculosis

Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
Room: Van Horne C

Speaker 3 of 8
Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA
The Dichotomy between Interleukin 1 and Type I Interferon during Mycobacterium Tuberculosis Infection Exposes Distinct and Opposing Classes of Inflammation

Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
Room: Van Horne C


Coffee Break

Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
Room: Van Horne C

Speaker 5 of 8
Craig R. Roy, Yale University School of Medicine, USA
Modulation of Type I Interferon Production during Infection by Vacuolar Pathogens

Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
Room: Van Horne C

Speaker 6 of 8
Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Human Dendritic Cell Subsets Differentially Respond to Vaccines

Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
Room: Van Horne C

Speaker 7 of 8
Terje Espevik, Norwegian University of Science and Technology, Norway
Short Talk: CD150 Positively Regulates TRAM Recruitment to E.coli Phagosomes and Type I IFN Secretion

Wednesday, March 22 | 8:00AM - 11:15AM
Type I IFN Regulation of Bacterial Infection and Disease
Room: Van Horne C

Speaker 8 of 8
Beiyun Caitlin Liu, Tufts University, USA
Short Talk: Host-Intrinsic Interferon Signaling Licenses GBP-Mediated Attack on Cytosolic Bacteria

Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 1 of 9
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA


Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 2 of 9
Russell E. Vance, University of California, Berkeley, USA
Activation of Inflammasomes by Bacterial Pathogens


Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 3 of 9
Amal Amer, Ohio State University, USA
Unconventional Functions of Inflammasomes


Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
This session is from Innate Immunity
Room: Van Horne A/B


Coffee Break


Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 5 of 9
Denise M. Monack, Stanford University, USA
Inflammasomes and Bacterial Infections


Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 6 of 9
Christian Holm, Aarhus University, Denmark
Short Talk: Nitro-Fatty Acids Can Suppress STING Signaling


Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 7 of 9
Peng Li, National Institute of Biological Sciences, China
Short Talk: Ubiquitination and Degradation of GBPs by Shigella Ipha9.8 Effector to Suppress Host Defenses


Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 8 of 9
Valesca Lindenberg, Institute of Medical Microbiology and Hospital Hygiene, Germany
Short Talk: Extensive Characterization of mGBPs Localization Chlamydia trachomatis Infection


Wednesday, March 22 | 8:00AM - 11:15AM
PRR Signaling in Bacterial and Viral Infection
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 9 of 9
Katelyn Susanne Burleigh, University of Washington, USA
Short Talk: Uncovering the Mechanism of E1A Antagonism of the cGAS-STING Pathway


Wednesday, March 22 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, March 22 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Wednesday, March 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Wednesday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, March 22 | 5:00PM - 7:00PM
Role of Type I IFN in Complex Autoimmunity
Room: Van Horne C

Speaker 1 of 4
* Virginia Pascual, Cornell University, USA
Pathogenic Functions of Type I IFN in SLE

Wednesday, March 22 | 5:00PM - 7:00PM
Role of Type I IFN in Complex Autoimmunity
Room: Van Horne C

Speaker 2 of 4
* Richard M. Siegel, NIAMS, National Institutes of Health, USA
Interferon, Anti-Interferon Antibodies and NK Cells in Systemic Autoimmunity


Wednesday, March 22 | 5:00PM - 7:00PM
Role of Type I IFN in Complex Autoimmunity
Room: Van Horne C

Speaker 3 of 4
Robert C. Axtell, Oklahoma Medical Research Foundation, USA
Immunological Heterogeneity in Neurological Autoimmunity: Lessons from Studying Type I Interferon Responses

Wednesday, March 22 | 5:00PM - 7:00PM
Role of Type I IFN in Complex Autoimmunity
Room: Van Horne C

Speaker 4 of 4
Mari L. Shinohara, Duke University, USA
Short Talk: Type-I Interferons and the NLRP3 Inflammasome in CNS Autoimmunity

Wednesday, March 22 | 5:00PM - 7:00PM
Inflammasome and NF-kB Regulatory Mechanisms
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 1 of 5
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA


Wednesday, March 22 | 5:00PM - 7:00PM
Inflammasome and NF-kB Regulatory Mechanisms
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 2 of 5
Christian Stehlik, Cedars-Sinai Medical Center, USA
Inflammasome Inhibition


Wednesday, March 22 | 5:00PM - 7:00PM
Inflammasome and NF-kB Regulatory Mechanisms
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 3 of 5
Eicke Latz, University of Bonn, Germany
Inflammasomes in Health and Disease


Wednesday, March 22 | 5:00PM - 7:00PM
Inflammasome and NF-kB Regulatory Mechanisms
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 4 of 5
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Metabolic Reprogramming in Innate Immunity and Inflammation


Wednesday, March 22 | 5:00PM - 7:00PM
Inflammasome and NF-kB Regulatory Mechanisms
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 5 of 5
Ali A. Zarrin, Genentech, Inc., USA
Short Talk: TPL2 Kinase Activates MEK-1/2 and/or MEK-3/6 to Regulate Inflammatory Pathways in Myeloid Cells


Wednesday, March 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Wednesday, March 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Mezzanine 2


Thursday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
Room: Van Horne C

Speaker 1 of 8
* Anne O'Garra, Francis Crick Institute, UK

Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
Room: Van Horne C

Speaker 2 of 8
Jae U. Jung, Keck School of Medicine of University of Southern California, USA
TRIM-Mediated Control of Type I IFN Pathway

Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
Room: Van Horne C

Speaker 3 of 8
Marco Colonna, Washington University School of Medicine, USA
Targeting Type I IFN Activity through Plasmacytoid DC

Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
Room: Van Horne C


Coffee Break

Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
Room: Van Horne C

Speaker 5 of 8
Laurel L. Lenz, University of Colorado, USA
Role of Type I - Type II IFN Crosstalk in Macrophage Effector Function

Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
Room: Van Horne C

Speaker 6 of 8
Gideon Schreiber, Weizmann Institute, Israel
The Molecular Basis for Differential Activity of Type I Interferons

Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
Room: Van Horne C

Speaker 7 of 8
Paul J. Hertzog, Hudson Institute of Medical Research, Australia
Short Talk: Systems Biology of Type I Interferon Responses

Thursday, March 23 | 8:00AM - 11:15AM
Mechanisms Underlying Divergent Functions of Type I IFNs
Room: Van Horne C

Speaker 8 of 8
Ronald L. Rabin, US Food and Drug Administration, USA
Short Talk: A Potential Modulatory Role for IFNalpha1 Dependent on its Low Affinity for IFNAR2

Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 1 of 9
* Mihai G. Netea, Radboud University, Netherlands


Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 2 of 9
Daniel Graham, Massachusetts General Hospital, USA
Host Genetics and Microbe Interactions in Human Disease


Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 3 of 9
Kathy D. McCoy, University of Calgary, Canada
Intestinal Commensal Microbiota and Education of the Innate Immune System


Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
This session is from Innate Immunity
Room: Van Horne A/B


Coffee Break


Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 5 of 9
Gabriel Nuñez, University of Michigan, USA
Control of Pathogen Colonization by Host Immunity and the Microbiota in the Gut


Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 6 of 9
Andrew T. Gewirtz, Georgia State University, USA
Microbial-Mediated Protection from Infectious Disease


Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 7 of 9
Prosper N. Boyaka, Ohio State University, USA
Regulation of Mucosal Immunity by Toxins and Microbiota


Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 8 of 9
Grace Yi Chen, University of Michigan, USA
Short Talk: NLRP6 Limits Colonization of Akkermansia to Protect Against the Development of Colitis and Colon Tumorigenesis


Thursday, March 23 | 8:00AM - 11:45AM
Interactions between Microbiota and the Innate Immune System
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 9 of 9
Felix Yarovinsky, University of Rochester Medical Center, USA
Short Talk: Loss of Paneth Cell Autophagy Leads to Catastrophic Susceptibility to Acute Gastrointestinal Inflammation


Thursday, March 23 | 11:00AM - 2:30PM
On Own for Lunch


Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
Room: Van Horne C

Speaker 1 of 9
* Marco Colonna, Washington University School of Medicine, USA

Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
Room: Van Horne C

Speaker 2 of 9
* Raphaela Theresia Goldbach-Mansky, NIAID, National Institutes of Health, USA

Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
Room: Van Horne C

Speaker 3 of 9
Kebin Liu, Medical College of Georgia, USA
Jak-STAT-Mediated Chronic Inflammation Impairs Cytotoxic T Lymphocyte Activation to Decrease Anti-PD-1 Immunotherapy Efficacy in Pancreatic Cancer

Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
Room: Van Horne C

Speaker 4 of 9
Jacquelyn Gorman, Seattle Children's Research Institute, USA
The IFIH1A946T Coding Variant Mediates an Interferon Program that Limits Viral Infection but Increases the Risk for Autoimmunity

Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
Room: Van Horne C

Speaker 5 of 9
Mark E. Kleinman, University of Kentucky, USA
Epigenetic Regulation of Type I IFN Response in Age-Related Macular Degeneration

Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
Room: Van Horne C

Speaker 6 of 9
Elisaveta Voynova, Medimmune, USA
Blockade of Critical Immune Regulators Results in Different Roads to Pathogenesis in Primary Sjögren’s Syndrome

Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
Room: Van Horne C

Speaker 7 of 9
Mona Motwani, University of Massachusetts, USA
The cGAS-STING Pathway Restrains Systemic Autoimmunity

Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
Room: Van Horne C

Speaker 8 of 9
Simone Caielli, Baylor Institute for Immunology Research, USA
Oxidized Mitochondrial DNA is a Powerful Activator of Human pDCs and Induces a Lupus-Specific CD4 T Cell Phenotype

Thursday, March 23 | 2:30PM - 4:30PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignan
cy
Room: Van Horne C

Speaker 9 of 9
Stephen Rubino, Brigham and Women's Hospital, USA
Activated Microglia Induce Type 1-interferon Dependent Neurodegeneration

Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 1 of 8
* Amal Amer, Ohio State University, USA


Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 2 of 8
* Dana Philpott, University of Toronto, Canada


Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 3 of 8
Eric P. Hanson, National Institutes of Health, USA
A Novel NEMO Isoform Mediates Enhanced Antiviral Activity and Autoinflammatory Disease via Stabilization of IKKepsilon


Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 4 of 8
Kiva V. Brennan, Trinity College Dublin, Ireland
Designing Vaccines for the Paediatric Population; Potential for Cytosolic Nucleic Acids as Vaccine Adjuvants


Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 5 of 8
Nesrin Ozoren, Bogazici University, Turkey
ASC Specks as Vaccine Technology


Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 6 of 8
Jingjin Ding, National Institute of Biological Sciences, China
LPS Binding to Caspase-11/4/5 Triggers Pyroptosis by Releasing the Pore-Forming Activity of GSDMD


Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 7 of 8
Orna Rabinovich-Ernst, NIAID, National Institutes of Health, USA
An Arrayed Genome-Wide RNAi Screen for the Discovery of Novel Inflammasome Regulators


Thursday, March 23 | 2:30PM - 4:00PM
Workshop 3: PRRs in Inflammatory Diseases
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 8 of 8
Thomas A. Kufer, University of Hohenheim, Germany
Roles of NLRP10 in Innate and Adaptive Immunity


Thursday, March 23 | 4:00PM - 4:30PM
Navigating the Peer Review Process
This session is from Innate Immunity
Room: Van Horne A/B
Information will be provided about how to understand the NIH peer review system with a focus on recent changes to the review process. Anyone interested in learning more about preparing an NIH grant application and tips about the review of grant applications is welcome to attend.
Speaker 1 of 1
* Tina M. McIntyre, National Institutes of Health, USA


Thursday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, March 23 | 5:00PM - 6:45PM
Tailoring Type I IFN Interventions to Achieve Cure
Room: Van Horne C

Speaker 1 of 4
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA

Thursday, March 23 | 5:00PM - 6:45PM
Tailoring Type I IFN Interventions to Achieve Cure
Room: Van Horne C

Speaker 2 of 4
Geraldine P. Grouard-Vogel, Neovacs, France
Overexpression of IFNalpha and Derived Diseases: Innovative Approach with a Therapeutic Vaccine IFNalpha Kinoid

Thursday, March 23 | 5:00PM - 6:45PM
Tailoring Type I IFN Interventions to Achieve Cure
Room: Van Horne C

Speaker 3 of 4
Gary P. Sims, MedImmune Inc, USA
Novel Pathogenic Role for IgE in SLE, and Pharmacological Blockade of Type I IFN Receptor in Patients

Thursday, March 23 | 5:00PM - 6:45PM
Tailoring Type I IFN Interventions to Achieve Cure
Room: Van Horne C

Speaker 4 of 4
John J. O'Shea, NIAMS, National Institutes of Health, USA
Targeting Type I IFN Signaling Pathways

Thursday, March 23 | 5:00PM - 6:45PM
Innate Immune Receptors and Metabolism
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 1 of 5
* Prosper N. Boyaka, Ohio State University, USA


Thursday, March 23 | 5:00PM - 6:45PM
Innate Immune Receptors and Metabolism
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 2 of 5
Marcia A. Munoz, Garvan Institute of Medical Research, Australia
Short Talk: Defective Protein Prenylation Is a Diagnostic Biomarker for Mevalonate Kinase Deficiency


Thursday, March 23 | 5:00PM - 6:45PM
Innate Immune Receptors and Metabolism
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 3 of 5
Je-Wook Yu, Yonsei University College of Medicine, South Korea
Short Talk: 25-Hydroxycholesterol Contributes to Cerebral Inflammation of X-Linked Adrenoleukodystrophy (X-ALD) through Activation of the NLRP3 Inflammasome


Thursday, March 23 | 5:00PM - 6:45PM
Innate Immune Receptors and Metabolism
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 4 of 5
Vishwa Deep Dixit, Yale University, USA
Metabolic Control of Inflammasomes


Thursday, March 23 | 5:00PM - 6:45PM
Innate Immune Receptors and Metabolism
This session is from Innate Immunity
Room: Van Horne A/B

Speaker 5 of 5
Mihai G. Netea, Radboud University, Netherlands
Metabolic Basis for Trained Innate Immunity


Thursday, March 23 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Van Horne C

Speaker 1 of 1
* Alan Sher, NIAID, National Institutes of Health, USA

Thursday, March 23 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Innate Immunity
Room: Van Horne A/B


Thursday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Thursday, March 23 | 8:00PM - 11:00PM
Entertainment
Room: Mezzanine 2
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 23 | 8:00PM - 11:00PM
Cash Bar
Room: Mezzanine 2


Friday, March 24 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.