Web Desc
Molecular Mechanisms of Heart Development
joint with RNA-Based Approaches in Cardiovascular Disease
Organizer(s): Benoit G. Bruneau, Brian L. Black and Margaret E. Buckingham
Date: March 26 - 30, 2017
Location: Keystone Resort, Keystone, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
The heart is the first organ to form in the embryo, and its development and function is essential for life. Defects in heart formation result in congenital heart disease, which affects at least 1% of live births. The lessons learned from heart development are also critical for the development of strategies aimed at regenerating diseased adult hearts. This meeting will address advances in our understanding of cellular and molecular mechanisms of heart development, with a view toward congenital heart disease and cardiac regeneration. It will bring together developmental biologists, cardiologists, geneticists and basic scientists from many disciplines to discuss current findings and to promote multi-disciplinary collaborations. The pairing with the Keystone Symposia meeting on “RNA-Based Approaches in Cardiovascular Disease” presents an opportunity to bridge exciting fields in cardiovascular biology.
Scholarship Deadline: November 30 2016
Discounted Abstract Deadline: November 30 2016
Abstract Deadline: January 11 2017
Discounted Registration Deadline: January 26 2017
We gratefully acknowledge additional support for this conference from:
Bethyl Laboratories, Inc.March of Dimes Foundation, Grant No. 4-FY16-317
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL135924-01
Funding for this conference was made possible (in part) by 1R13HL135924-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 26 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, March 26 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Monday, March 27 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Grays/Longs Peak

Speaker 1 of 3
* Benoit G. Bruneau, Gladstone Institutes, USA

Monday, March 27 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Grays/Longs Peak

Speaker 2 of 3
* Thomas Thum, Medical School Hannover, Germany

Monday, March 27 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Grays/Longs Peak

Speaker 3 of 3
Eric N. Olson, University of Texas Southwestern Medical Center, USA
Following the Heart

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak

Speaker 1 of 7
* Benoit G. Bruneau, Gladstone Institutes, USA

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak

Speaker 2 of 7
* Thomas Thum, Medical School Hannover, Germany

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak

Speaker 3 of 7
Stefanie Dimmeler, University of Frankfurt, Germany
Non-coding RNAs in Cardiovascular Repair and Aging

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak


Coffee Break

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak

Speaker 5 of 7
William C. Sessa, Yale University School of Medicine, USA
Vascular Therapeutics Approaches using miRNAs

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak

Speaker 6 of 7
Laurie A. Boyer, Massachusetts Institute of Technology, USA
Long Noncoding RNAs in Heart Development and Differentiation

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak

Speaker 7 of 7
Tilman Ziegler, Klinikum rechts der Isar der TU München, Germany
Short Talk: LNA Mediated Inhibition of miR-132 Prevents Hypertrophy Induced Cardiomyopathy in Pigs

Monday, March 27 | 11:15AM - 2:30PM
On Own for Lunch


Monday, March 27 | 11:15AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Monday, March 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
Room: Longs Peak

Speaker 1 of 7
* Eric Small, University of Rochester, USA

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
Room: Longs Peak

Speaker 2 of 7
Nicole Schlüßler, Goethe University Frankfurt, Germany
A LncRNA Locus in the Genomic Region of Hand2 is Essential for Cardiac Development

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
Room: Longs Peak

Speaker 3 of 7
Alexandre R. Colas, Sanford-Burnham Medical Research Institute, USA
Id Genes Are Essential For Early Heart Formation

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
Room: Longs Peak

Speaker 4 of 7
Sunil K. Verma, University of Texas Medical Branch, USA
Role of the RNA Binding Protein Rbfox2 in Hypoplastic Left Heart Syndrome

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
Room: Longs Peak

Speaker 5 of 7
Christian Mosimann, University of Zürich, Switzerland
An Ancient Regulatory Program Controls the Emergence of Cardiogenic Lateral Plate Mesoderm

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
Room: Longs Peak

Speaker 6 of 7
Li Qian, University of North Carolina at Chapel Hill, USA
Single Cell Transcriptomics Reveals a Deterministic Trajectory of Cell Fate Conversion during Direct Cardiac Reprogramming

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
Room: Longs Peak

Speaker 7 of 7
Min Zhang, Shanghai Children's Medical Center, China
Atrial Fibrillation-Associated Functional Element Regulates Pitx2 Expression via CTCF-Mediated Long-Range Interaction

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Basic and Novel Tools for RNA Research
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 1 of 6
* Carlos Fernandez-Hernando, Yale School of Medicine, USA


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Basic and Novel Tools for RNA Research
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 2 of 6
* Leon Johannes De Windt, Maastricht University, Netherlands


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Basic and Novel Tools for RNA Research
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 3 of 6
Esther E. Creemers, Academic Medical Center, Netherlands
Circular RNA Profiling and Implications for Cardiac Disease


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Basic and Novel Tools for RNA Research
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 4 of 6
Mark Mercola, Stanford University, USA
High Throughput Screening as a Massive Omics Approach to Understand the Heart


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Basic and Novel Tools for RNA Research
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 5 of 6
Lior Zangi, Icahn School of Medicine at Mount Sinai, USA
Gene Therapy Approach for Cardiac Regeneration using Modified mRNA


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Basic and Novel Tools for RNA Research
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 6 of 6
Cristina Espinosa-Diez, Oregon Health and Science University, USA
A MicroRNA Regulated Incoherent Feedforward Loop Drives Vascular Senescence


Monday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 27 | 5:00PM - 7:00PM
Cardiac Lineages
Room: Longs Peak

Speaker 1 of 5
* Kristy Red-Horse, Stanford University, USA

Monday, March 27 | 5:00PM - 7:00PM
Cardiac Lineages
Room: Longs Peak

Speaker 2 of 5
Margaret E. Buckingham, Institut Pasteur, France
Cardiac Cell Lineages and the Second Heart Field

Monday, March 27 | 5:00PM - 7:00PM
Cardiac Lineages
Room: Longs Peak

Speaker 3 of 5
Lionel Christiaen, New York University, USA
Regulation of Cardiopharyngeal Multipotency and Early Fate Specification in a Simple Chordate

Monday, March 27 | 5:00PM - 7:00PM
Cardiac Lineages
Room: Longs Peak

Speaker 4 of 5
Caroline E. Burns, Harvard Medical School, Boston Children's Hospital, USA
Development of the Cardiopharyngeal Lineage in Zebrafish

Monday, March 27 | 5:00PM - 7:00PM
Cardiac Lineages
Room: Longs Peak

Speaker 5 of 5
Nicole Dubois, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Foxa2 Marks a Ventricular Progenitor Population during Heart Development

Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 1 of 8
* Manuel Mayr, King's College, University of London, UK


Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 2 of 8
* Susmita Sahoo, Icahn School of Medicine at Mount Sinai, USA


Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 3 of 8
Carlos Fernandez-Hernando, Yale School of Medicine, USA
Noncoding RNAs as Paracrine Players in Vascular Inflammation and Lipid Metabolism


Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 4 of 8
Denise Hilfiker-Kleiner, Medizinische Hochschule Hannover, Germany
Pathophysiology of Peripartum Cardiomyopathy Links Prolactin to the PAI-1/uPAR System: Modulation of NF-kB Signaling and miR146a as Therapeutic Options


Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 5 of 8
Paula da Costa Martins, Maastricht University, Netherlands
Short Talk: Cardiomyocyte-Derived Exosomes Mediate Pathological Cardiac Microvascular Remodeling


Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 6 of 8
Yuri D'Alessandra, Centro Cardiologico Monzino, Italy
Short Talk: Circulating MicroRNAs as Biomarkers of Long-Term Doxorubicin-Induced Cardiotoxicity


Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 7 of 8
Stefanie Novakowski, University of British Columbia, Canada
Short Talk: Engineering Platelets for the Delivery of RNA


Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 8 of 8
Christa L. Trexler, University of Colorado Boulder, USA
Short Talk: Cardiomyocyte Function and Gene Expression are Influenced by Biological Sex


Monday, March 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Monday, March 27 | 7:30PM - 10:00PM
Poster Session 1
Room: Red Cloud/Shavano/Torreys


Tuesday, March 28 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
Room: Longs Peak

Speaker 1 of 7
* Kelly Smith, University of Queensland, Australia

Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
Room: Longs Peak

Speaker 2 of 7
Kristy Red-Horse, Stanford University, USA
Cell Fate Decisions during Coronary Artery Development

Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
Room: Longs Peak

Speaker 3 of 7
Kenneth D. Poss, Duke University Medical Center, USA
Cardiac Regeneration

Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
Room: Longs Peak


Coffee Break

Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
Room: Longs Peak

Speaker 5 of 7
Bin Zhou, Albert Einstein College of Medicine, USA
Developmental Mechanisms of Coronary Artery Formation

Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
Room: Longs Peak

Speaker 6 of 7
Paul R. Riley, University of Oxford, UK
Developmental Programming of the Cardiac Lymphatics

Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
Room: Longs Peak

Speaker 7 of 7
Michael A. Trembley, University of Rochester Medical Center, USA
Short Talk: Novel Mechanisms of Epicardial-Derived Cell Mobilization

Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 1 of 9
* Roger J. Hajjar, Mount Sinai School of Medicine, USA


Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 2 of 9
* Gerald W. Dorn, II, Washington University School of Medicine, USA


Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 3 of 9
Susmita Sahoo, Icahn School of Medicine at Mount Sinai, USA
Exosomes as a Diagnostic and Therapeutic Tool in Cardiovascular Disease


Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak


Coffee Break


Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 5 of 9
Eva van Rooij, Hubrecht Institute, Netherlands
Advances in Targeting miRNAs in the Heart


Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 6 of 9
Gianluigi Condorelli, Humanitas University, Italy
Chheaf1: A Novel lncRNA Regulating Cardiac Hypertrophy and Failure


Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 7 of 9
Elizabeth M. McNally, Northwestern University, USA
Targeting Muscular Dystrophy


Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 8 of 9
Robin Verjans, Maastricht University, Netherlands
Short Talk: Downregulation of the microRNA-221/222 Family Upon Heart Failure Contributes to Adverse Cardiac Fibrotic Remodeling


Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 9 of 9
Christine Wahlquist, Stanford University, USA
Short Talk: Modulation of Cardiomyocyte Physiology by Stretch-Induced miRNAs


Tuesday, March 28 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, March 28 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Tuesday, March 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Tuesday, March 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, March 28 | 5:00PM - 7:00PM
Gene Regulatory Mechanisms
Room: Longs Peak

Speaker 1 of 5
* Laurie A. Boyer, Massachusetts Institute of Technology, USA

Tuesday, March 28 | 5:00PM - 7:00PM
Gene Regulatory Mechanisms
Room: Longs Peak

Speaker 2 of 5
Vincent M. Christoffels, Academic Medical Center, Netherlands
Transcriptional Regulation of the Electrical Activity Pattern of the Heart

Tuesday, March 28 | 5:00PM - 7:00PM
Gene Regulatory Mechanisms
Room: Longs Peak

Speaker 3 of 5
Benoit G. Bruneau, Gladstone Institutes, USA
Transcriptional Regulation of Heart Development

Tuesday, March 28 | 5:00PM - 7:00PM
Gene Regulatory Mechanisms
Room: Longs Peak

Speaker 4 of 5
Brian L. Black, University of California, San Francisco, USA
Cooperative Activation of Cardiac Transcription through Myocardin Bridging of Paired MEF2 Sites

Tuesday, March 28 | 5:00PM - 7:00PM
Gene Regulatory Mechanisms
Room: Longs Peak

Speaker 5 of 5
Rangarajan Nadadur, University of Chicago, USA
Short Talk: Differential Enhancer Transcription Defines a Disease-Associated Gene Regulatory Network

Tuesday, March 28 | 5:00PM - 7:00PM
Novel Approaches in RNA Detection and Networks
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 1 of 6
* Gianluigi Condorelli, Humanitas University, Italy


Tuesday, March 28 | 5:00PM - 7:00PM
Novel Approaches in RNA Detection and Networks
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 2 of 6
* Christian Kupatt, Technical University Munich, Germany


Tuesday, March 28 | 5:00PM - 7:00PM
Novel Approaches in RNA Detection and Networks
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 3 of 6
Stefan Engelhardt, Technical University of Munich, Germany
Approaches to Identify Crucial miRNA Mechanisms of Action


Tuesday, March 28 | 5:00PM - 7:00PM
Novel Approaches in RNA Detection and Networks
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 4 of 6
Arthur A. Levin, Avidity Biosciences, USA
Toxicological Considerations in Oligonucleotide Therapeutics Development


Tuesday, March 28 | 5:00PM - 7:00PM
Novel Approaches in RNA Detection and Networks
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 5 of 6
Anne Katrine Johansen, Hubrecht Institute, Netherlands
Short Talk: CRISPR/Cas9-based Postnatal Gene Editing to Study Cardiac Gene Function in vivo


Tuesday, March 28 | 5:00PM - 7:00PM
Novel Approaches in RNA Detection and Networks
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 6 of 6
Prabhu Mathiyalagan, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Dynamic Regulation of m6A RNA methylation is a Novel Remodeling Mechanism of the Ischemic Heart


Tuesday, March 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Tuesday, March 28 | 7:30PM - 10:00PM
Poster Session 2
Room: Red Cloud/Shavano/Torreys


Wednesday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
Room: Longs Peak

Speaker 1 of 7
* Vincent M. Christoffels, Academic Medical Center, Netherlands

Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
Room: Longs Peak

Speaker 2 of 7
Christine E. Seidman, Harvard Medical School, USA
Steps and Missteps in Building the Heart

Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
Room: Longs Peak

Speaker 3 of 7
Ivan P. Moskowitz, University of Chicago, USA
A Timing Switch for Cardiac Progenitor Differentiation

Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
Room: Longs Peak


Coffee Break

Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
Room: Longs Peak

Speaker 5 of 7
William T. Pu, Children's Hospital, Harvard Medical School, USA
iPSC-CM Models of Congenital Heart Disease

Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
Room: Longs Peak

Speaker 6 of 7
Richard P. Harvey, University of New South Wales, Victor Chang Cardiac Research Institute, Australia
Transcriptional Targets and Off-Targets in Congenital Heart Disease

Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
Room: Longs Peak

Speaker 7 of 7
Zhe Han, Children's National Health System, USA
Short Talk: High Throughput in vivo Functional Validation of Candidate Congenital Heart Disease Genes in Drosophila

Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 1 of 8
* Stefan Engelhardt, Technical University of Munich, Germany


Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 2 of 8
Gerald W. Dorn, II, Washington University School of Medicine, USA
Orchestration of Smoothened/Hedgehog/GATA Transcriptional Activity by GRKs 2, 5, and 6 in Developing Mouse Hearts


Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 3 of 8
Yibin Wang, University of California, Los Angeles, David Geffen School of Medicine, USA
A lncRNA-Dependent Epigenetic Check-Point for Cardiac Hypertrophy and Remodeling


Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak


Coffee Break


Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 5 of 8
Thomas Thum, Medical School Hannover, Germany
lncRNAs in Cardiac Remodeling


Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 6 of 8
Venkata Naga Srikanth Garikipati, Temple University, USA
Short Talk: Long Noncoding Circular RNA mmu_circ_008396 Modulates Cardiac Repair After Myocardial Infarction


Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 7 of 8
Da-Zhi Wang, Children's Hospital Boston, USA
Short Talk: Genome-Wide Identification and Characterization of Cardiac Hypertrophy-Related Long Noncoding RNAs


Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 8 of 8
Samir Ounzain, HAYA Therapeutics, Switzerland
Short Talk: Transposable Elements Contribute to the Functional and Regulatory Characteristics of Cardiovascular lncRNAs


Wednesday, March 29 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, March 29 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Wednesday, March 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Wednesday, March 29 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, March 29 | 5:00PM - 7:00PM
Mechanisms of Cardiac Growth and Morphogenesis
Room: Longs Peak

Speaker 1 of 5
* Caroline E. Burns, Harvard Medical School, Boston Children's Hospital, USA

Wednesday, March 29 | 5:00PM - 7:00PM
Mechanisms of Cardiac Growth and Morphogenesis
Room: Longs Peak

Speaker 2 of 5
Anthony B. Firulli, Wells Center for Pediatrics Research, USA
Characterization of a Hand1 Left Ventricular Enhancer and Development of a Left Ventricular Specific Cre Driver

Wednesday, March 29 | 5:00PM - 7:00PM
Mechanisms of Cardiac Growth and Morphogenesis
Room: Longs Peak

Speaker 3 of 5
Katherine E. Yutzey, Cincinnati Children's Hospital Medical Center, USA
Developmental Mechanisms of Heart Valve Disease

Wednesday, March 29 | 5:00PM - 7:00PM
Mechanisms of Cardiac Growth and Morphogenesis
Room: Longs Peak

Speaker 4 of 5
James F. Martin, Baylor College of Medicine, USA
The Hippo Pathway in Heart Development and Regeneration

Wednesday, March 29 | 5:00PM - 7:00PM
Mechanisms of Cardiac Growth and Morphogenesis
Room: Longs Peak

Speaker 5 of 5
Daniela Panakova, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Planar Cell Polarity Pathway Links Mechanosensitive Feedback between Cardiac Remodeling and Muscle Differentiation

Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 1 of 8
* Yibin Wang, University of California, Los Angeles, David Geffen School of Medicine, USA


Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 2 of 8
* Patrick Most, University of Heidelberg, Germany


Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 3 of 8
Rusty Montgomery, miRagen Therapeutics, Inc., USA
Pharmacokinetic/Dynamic Aspects of Oligonucleotide Therapeutics


Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 4 of 8
Christian Kupatt, Technical University Munich, Germany
Micro-RNAs based Therapeutics in Porcine Cardiac Disease Models


Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 5 of 8
Rabea Hinkel, Klinikum rechts der Isar, TUM, Germany
Short Talk: Cardio-Protective Potential of miR-92a Inhibition in Myocardial Ischemia


Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 6 of 8
Dongtak Jeong, Ichan School of Medicine at Mount Sinai, USA
Short Talk: AAV9 miR-25 Tough Decoy Transfer Improves Cardiac Function in HF and Aged MDX/UTRN KO Mice


Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 7 of 8
Adam E. Mullick, Ionis Pharmaceuticals, Inc., USA
Short Talk: Characterization of Cardiac Gen 2.5 Antisense Oligonucleotide Activity


Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 8 of 8
Deepak Prabhu Ramanujam, Institute of Pharmakologie und Toxikologie, Technische Universitaet Muenchen, Germany
Short Talk: Inhibition of microRNA-21 Prevents Myocardial Remodeling in a Pig Model of Ischemia/Reperfusion Injury


Wednesday, March 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Wednesday, March 29 | 7:30PM - 10:00PM
Poster Session 3
Room: Red Cloud/Shavano/Torreys


Thursday, March 30 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak

Speaker 1 of 7
* Mauro Giacca, International Center for Genetic Engineering, Italy

Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak

Speaker 2 of 7
Deepak Srivastava, Gladstone Institutes, USA
Cellular Reprogramming Approaches for Cardiovascular Disease


Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak

Speaker 3 of 7
Nadia Mercader, Institut of Anatomy, University of Bern, Switzerland
Plasticity of Cardiomyocyte Fate during Heart Regeneration in Zebrafish

Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak


Coffee Break

Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak

Speaker 5 of 7
Leon Johannes De Windt, Maastricht University, Netherlands
Fetal miRNAs Play Large at Heart Failure

Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak

Speaker 6 of 7
Andrew H. Baker, University of Edinburgh, UK
Non Coding RNA Therapeutics in Cardiovascular Pathophysiology

Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak

Speaker 7 of 7
Chen Gao, University of California, Los Angeles, USA
Short Talk: Cytosolic RBFox1 In Cardiac Fibrosis Regulation

Thursday, March 30 | 11:00AM - 2:30PM
On Own for Lunch


Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 1 of 10
* Masaki Ieda, Keio University School of Medicine, Japan

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 2 of 10
* Eva van Rooij, Hubrecht Institute, Netherlands

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 3 of 10
Monika M. Gladka, Hubrecht Institute, Netherlands
Zeb2 Protects the Heart from Ischemic Damage


Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 4 of 10
Ajit Magadum, Icahn School of Medicine, Mount Sinai Hospital, USA
Cardiomyocyte-Specific Expression of Cell Cycle Inducer modRNA Induces Cardiac Regeneration

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 5 of 10
Shin Watanabe, Icahn School of Medicine at Mount Sinai, USA
miR-146a Regulates Cardiac Function by Targeting SUMO1/SERCA2a Pathway

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 6 of 10
Lina A. Shehadeh, University of Miami Miller School of Medicine, USA
Osteopontin RNA Aptamer Can Prevent and Reverse Pressure Overload-Induced Heart Failure

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 7 of 10
C. Geoffrey Burns, Harvard Medical School, Massachusetts General Hospital, USA
Cardiomyocyte Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 8 of 10
Honghai Liu, Children's Hospital of Pittsburgh of UPMC, USA
Repression of Epithelial Cell Transforming 2 (Ect2) Induces Binucleation of Cardiomyocytes

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 9 of 10
Thomas J. Cahill, University of Oxford, UK
Macrophages Activate Distinct Programs of Regeneration and Scar Formation to Direct Repair following Myocardial Infarction

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 10 of 10
Hamid el Azzouzi, Maastricht University, Netherlands
Targeted Deletion of ADAR1 in the Adult Heart Causes Severe Cardiac Dysfunction and Increased Lethality

Thursday, March 30 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 30 | 5:00PM - 6:45PM
Modeling Human Heart Development
Room: Longs Peak

Speaker 1 of 4
* Benoit G. Bruneau, Gladstone Institutes, USA

Thursday, March 30 | 5:00PM - 6:45PM
Modeling Human Heart Development
Room: Longs Peak

Speaker 2 of 4
Christine L. Mummery, Leiden University Medical Center, Netherlands
Developmental Patterning of Human Pluripotent Stem Cells: From Beating Cardiomycoytes to Heart Disease Models

Thursday, March 30 | 5:00PM - 6:45PM
Modeling Human Heart Development
Room: Longs Peak

Speaker 3 of 4
Charles E. Murry, University of Washington, USA
Networks Underlying Human Cardiovascular Differentiation

Thursday, March 30 | 5:00PM - 6:45PM
Modeling Human Heart Development
Room: Longs Peak

Speaker 4 of 4
Gordon M. Keller, University Health Network, MaRS Centre, Canada
Modeling Cardiovascular Development with Human Pluripotent Stem Cells

Thursday, March 30 | 5:00PM - 6:45PM
RNA Therapeutics in Clinical Translation
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 1 of 4
* Wolfram H. Zimmermann, University Medical Center Göttingen, Germany


Thursday, March 30 | 5:00PM - 6:45PM
RNA Therapeutics in Clinical Translation
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 2 of 4
Roger J. Hajjar, Mount Sinai School of Medicine, USA
Gene Therapy and Genome Editing for Heart Failure


Thursday, March 30 | 5:00PM - 6:45PM
RNA Therapeutics in Clinical Translation
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 3 of 4
Patrick Most, University of Heidelberg, Germany
Development of Nucleic-Acid Therapeutics for Cardiac and Vascular Disorder Treatment


Thursday, March 30 | 5:00PM - 6:45PM
RNA Therapeutics in Clinical Translation
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak

Speaker 4 of 4
Mauro Giacca, International Center for Genetic Engineering, Italy
Small RNA Therapy for Cardiac Regeneration


Thursday, March 30 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Longs Peak


Thursday, March 30 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from RNAs & Cardiovascular Disease
Room: Grays Peak


Thursday, March 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Thursday, March 30 | 8:00PM - 11:00PM
Entertainment
Room: Red Cloud/Shavano/Torreys
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 30 | 8:00PM - 11:00PM
Cash Bar
Room: Red Cloud/Shavano/Torreys


Friday, March 31 | 10:25AM - 10:25AM
Departure


*Session Chair.