Web Desc
RNA-Based Approaches in Cardiovascular Disease
joint with Molecular Mechanisms of Heart Development
Organizer(s): Thomas Thum and Roger J. Hajjar
Date: March 26 - 30, 2017
Location: Keystone Resort, Keystone, CO, USA
Sponsored by AstraZeneca
Summary of Meeting:
Cardiac diseases are the leading cause of death worldwide. RNA-based mechanisms and therapeutic approaches are emerging fields in cardiovascular science. This meeting will present and discuss latest developments using both coding RNA and noncoding RNA (such as microRNAs, long noncoding RNAs and circular RNAs) -based approaches to better understand and develop new therapeutic strategies for cardiac diseases. Attendees will benefit from workshops, specific sessions and industrial perspectives covering everything from basic science to clinical translation employing RNA therapeutics in cardiovascular medicine.
Scholarship Deadline: November 30 2016
Discounted Abstract Deadline: November 30 2016
Abstract Deadline: January 11 2017
Discounted Registration Deadline: January 26 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZeneca
We gratefully acknowledge additional support for this conference from:
Exiqon A/S
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL135954-01
Funding for this conference was made possible (in part) by 1R13HL135954-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 26 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, March 26 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Monday, March 27 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Grays/Longs Peak

Speaker 1 of 3
* Benoit G. Bruneau, Gladstone Institutes, USA

Monday, March 27 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Grays/Longs Peak

Speaker 2 of 3
* Thomas Thum, Medical School Hannover, Germany

Monday, March 27 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Grays/Longs Peak

Speaker 3 of 3
Eric N. Olson, University of Texas Southwestern Medical Center, USA
Following the Heart

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak

Speaker 1 of 7
* Benoit G. Bruneau, Gladstone Institutes, USA

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak

Speaker 2 of 7
* Thomas Thum, Medical School Hannover, Germany

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak

Speaker 3 of 7
Stefanie Dimmeler, University of Frankfurt, Germany
Non-coding RNAs in Cardiovascular Repair and Aging

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak


Coffee Break

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak

Speaker 5 of 7
William C. Sessa, Yale University School of Medicine, USA
Vascular Therapeutics Approaches using miRNAs

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak

Speaker 6 of 7
Laurie A. Boyer, Massachusetts Institute of Technology, USA
Long Noncoding RNAs in Heart Development and Differentiation

Monday, March 27 | 9:00AM - 11:15AM
Common RNA-Based Mechanisms in Cardiovascular Development an
d Pathology (Joint)

Room: Grays/Longs Peak

Speaker 7 of 7
Tilman Ziegler, Klinikum rechts der Isar der TU München, Germany
Short Talk: LNA Mediated Inhibition of miR-132 Prevents Hypertrophy Induced Cardiomyopathy in Pigs

Monday, March 27 | 11:15AM - 2:30PM
On Own for Lunch


Monday, March 27 | 11:15AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Monday, March 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Basic and Novel Tools for RNA Research
Room: Grays Peak

Speaker 1 of 6
* Carlos Fernandez-Hernando, Yale School of Medicine, USA

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Basic and Novel Tools for RNA Research
Room: Grays Peak

Speaker 2 of 6
* Leon Johannes De Windt, Maastricht University, Netherlands

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Basic and Novel Tools for RNA Research
Room: Grays Peak

Speaker 3 of 6
Esther E. Creemers, Academic Medical Center, Netherlands
Circular RNA Profiling and Implications for Cardiac Disease

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Basic and Novel Tools for RNA Research
Room: Grays Peak

Speaker 4 of 6
Mark Mercola, Stanford University, USA
High Throughput Screening as a Massive Omics Approach to Understand the Heart

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Basic and Novel Tools for RNA Research
Room: Grays Peak

Speaker 5 of 6
Lior Zangi, Icahn School of Medicine at Mount Sinai, USA
Gene Therapy Approach for Cardiac Regeneration using Modified mRNA

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Basic and Novel Tools for RNA Research
Room: Grays Peak

Speaker 6 of 6
Cristina Espinosa-Diez, Oregon Health and Science University, USA
A MicroRNA Regulated Incoherent Feedforward Loop Drives Vascular Senescence

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
This session is from Cardiac Development
Room: Longs Peak

Speaker 1 of 7
* Eric Small, University of Rochester, USA


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
This session is from Cardiac Development
Room: Longs Peak

Speaker 2 of 7
Nicole Schlüßler, Goethe University Frankfurt, Germany
A LncRNA Locus in the Genomic Region of Hand2 is Essential for Cardiac Development


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
This session is from Cardiac Development
Room: Longs Peak

Speaker 3 of 7
Alexandre R. Colas, Sanford-Burnham Medical Research Institute, USA
Id Genes Are Essential For Early Heart Formation


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
This session is from Cardiac Development
Room: Longs Peak

Speaker 4 of 7
Sunil K. Verma, University of Texas Medical Branch, USA
Role of the RNA Binding Protein Rbfox2 in Hypoplastic Left Heart Syndrome


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
This session is from Cardiac Development
Room: Longs Peak

Speaker 5 of 7
Christian Mosimann, University of Zürich, Switzerland
An Ancient Regulatory Program Controls the Emergence of Cardiogenic Lateral Plate Mesoderm


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
This session is from Cardiac Development
Room: Longs Peak

Speaker 6 of 7
Li Qian, University of North Carolina at Chapel Hill, USA
Single Cell Transcriptomics Reveals a Deterministic Trajectory of Cell Fate Conversion during Direct Cardiac Reprogramming


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Gene Regulatory Mechanisms
This session is from Cardiac Development
Room: Longs Peak

Speaker 7 of 7
Min Zhang, Shanghai Children's Medical Center, China
Atrial Fibrillation-Associated Functional Element Regulates Pitx2 Expression via CTCF-Mediated Long-Range Interaction


Monday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
Room: Grays Peak

Speaker 1 of 8
* Manuel Mayr, King's College, University of London, UK

Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
Room: Grays Peak

Speaker 2 of 8
* Susmita Sahoo, Icahn School of Medicine at Mount Sinai, USA

Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
Room: Grays Peak

Speaker 3 of 8
Carlos Fernandez-Hernando, Yale School of Medicine, USA
Noncoding RNAs as Paracrine Players in Vascular Inflammation and Lipid Metabolism


Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
Room: Grays Peak

Speaker 4 of 8
Denise Hilfiker-Kleiner, Medizinische Hochschule Hannover, Germany
Pathophysiology of Peripartum Cardiomyopathy Links Prolactin to the PAI-1/uPAR System: Modulation of NF-kB Signaling and miR146a as Therapeutic Options

Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
Room: Grays Peak

Speaker 5 of 8
Paula da Costa Martins, Maastricht University, Netherlands
Short Talk: Cardiomyocyte-Derived Exosomes Mediate Pathological Cardiac Microvascular Remodeling

Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
Room: Grays Peak

Speaker 6 of 8
Yuri D'Alessandra, Centro Cardiologico Monzino, Italy
Short Talk: Circulating MicroRNAs as Biomarkers of Long-Term Doxorubicin-Induced Cardiotoxicity

Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
Room: Grays Peak

Speaker 7 of 8
Stefanie Novakowski, University of British Columbia, Canada
Short Talk: Engineering Platelets for the Delivery of RNA

Monday, March 27 | 5:00PM - 7:15PM
Fundamentals in RNA Diagnostics and Paracrine Effects
Room: Grays Peak

Speaker 8 of 8
Christa L. Trexler, University of Colorado Boulder, USA
Short Talk: Cardiomyocyte Function and Gene Expression are Influenced by Biological Sex

Monday, March 27 | 5:00PM - 7:00PM
Cardiac Lineages
This session is from Cardiac Development
Room: Longs Peak

Speaker 1 of 5
* Kristy Red-Horse, Stanford University, USA


Monday, March 27 | 5:00PM - 7:00PM
Cardiac Lineages
This session is from Cardiac Development
Room: Longs Peak

Speaker 2 of 5
Margaret E. Buckingham, Institut Pasteur, France
Cardiac Cell Lineages and the Second Heart Field


Monday, March 27 | 5:00PM - 7:00PM
Cardiac Lineages
This session is from Cardiac Development
Room: Longs Peak

Speaker 3 of 5
Lionel Christiaen, New York University, USA
Regulation of Cardiopharyngeal Multipotency and Early Fate Specification in a Simple Chordate


Monday, March 27 | 5:00PM - 7:00PM
Cardiac Lineages
This session is from Cardiac Development
Room: Longs Peak

Speaker 4 of 5
Caroline E. Burns, Harvard Medical School, Boston Children's Hospital, USA
Development of the Cardiopharyngeal Lineage in Zebrafish


Monday, March 27 | 5:00PM - 7:00PM
Cardiac Lineages
This session is from Cardiac Development
Room: Longs Peak

Speaker 5 of 5
Nicole Dubois, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Foxa2 Marks a Ventricular Progenitor Population during Heart Development


Monday, March 27 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Monday, March 27 | 7:30PM - 10:00PM
Poster Session 1
Room: Red Cloud/Shavano/Torreys


Tuesday, March 28 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Tuesday, March 28 | 8:00AM - 8:45AM
Keynote Address
Room: Grays Peak

Speaker 1 of 3
* Roger J. Hajjar, Mount Sinai School of Medicine, USA

Tuesday, March 28 | 8:00AM - 8:45AM
Keynote Address
Room: Grays Peak

Speaker 2 of 3
* Gerald W. Dorn, II, Washington University School of Medicine, USA

Tuesday, March 28 | 8:00AM - 8:45AM
Keynote Address
Room: Grays Peak

Speaker 3 of 3
Manuel Mayr, King's College, University of London, UK
A Systems Biology Approach: Circulating Noncoding RNAs as Innovative Diagnostic and Prognostic Markers of Cardiovascular Disease

Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
This session is from Cardiac Development
Room: Longs Peak

Speaker 1 of 7
* Kelly Smith, University of Queensland, Australia


Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
This session is from Cardiac Development
Room: Longs Peak

Speaker 2 of 7
Kristy Red-Horse, Stanford University, USA
Cell Fate Decisions during Coronary Artery Development


Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
This session is from Cardiac Development
Room: Longs Peak

Speaker 3 of 7
Kenneth D. Poss, Duke University Medical Center, USA
Cardiac Regeneration


Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
This session is from Cardiac Development
Room: Longs Peak


Coffee Break


Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
This session is from Cardiac Development
Room: Longs Peak

Speaker 5 of 7
Bin Zhou, Albert Einstein College of Medicine, USA
Developmental Mechanisms of Coronary Artery Formation


Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
This session is from Cardiac Development
Room: Longs Peak

Speaker 6 of 7
Paul R. Riley, University of Oxford, UK
Developmental Programming of the Cardiac Lymphatics


Tuesday, March 28 | 8:00AM - 11:00AM
Epicardium and Coronaries
This session is from Cardiac Development
Room: Longs Peak

Speaker 7 of 7
Michael A. Trembley, University of Rochester Medical Center, USA
Short Talk: Novel Mechanisms of Epicardial-Derived Cell Mobilization


Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
Room: Grays Peak

Speaker 1 of 9
* Roger J. Hajjar, Mount Sinai School of Medicine, USA

Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
Room: Grays Peak

Speaker 2 of 9
* Gerald W. Dorn, II, Washington University School of Medicine, USA

Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
Room: Grays Peak

Speaker 3 of 9
Susmita Sahoo, Icahn School of Medicine at Mount Sinai, USA
Exosomes as a Diagnostic and Therapeutic Tool in Cardiovascular Disease

Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
Room: Grays Peak


Coffee Break

Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
Room: Grays Peak

Speaker 5 of 9
Eva van Rooij, Hubrecht Institute, Netherlands
Advances in Targeting miRNAs in the Heart

Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
Room: Grays Peak

Speaker 6 of 9
Gianluigi Condorelli, Humanitas University, Italy
Chheaf1: A Novel lncRNA Regulating Cardiac Hypertrophy and Failure

Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
Room: Grays Peak

Speaker 7 of 9
Elizabeth M. McNally, Northwestern University, USA
Targeting Muscular Dystrophy

Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
Room: Grays Peak

Speaker 8 of 9
Robin Verjans, Maastricht University, Netherlands
Short Talk: Downregulation of the microRNA-221/222 Family Upon Heart Failure Contributes to Adverse Cardiac Fibrotic Remodeling

Tuesday, March 28 | 8:45AM - 12:00PM
Noncoding RNA Therapeutics: What Have We Learned?
Room: Grays Peak

Speaker 9 of 9
Christine Wahlquist, Stanford University, USA
Short Talk: Modulation of Cardiomyocyte Physiology by Stretch-Induced miRNAs

Tuesday, March 28 | 12:00PM - 5:00PM
On Own for Lunch


Tuesday, March 28 | 12:00PM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Tuesday, March 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Tuesday, March 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, March 28 | 5:00PM - 7:00PM
Novel Approaches in RNA Detection and Networks
Room: Grays Peak

Speaker 1 of 6
* Gianluigi Condorelli, Humanitas University, Italy

Tuesday, March 28 | 5:00PM - 7:00PM
Novel Approaches in RNA Detection and Networks
Room: Grays Peak

Speaker 2 of 6
* Christian Kupatt, Technical University Munich, Germany

Tuesday, March 28 | 5:00PM - 7:00PM
Novel Approaches in RNA Detection and Networks
Room: Grays Peak

Speaker 3 of 6
Stefan Engelhardt, Technical University of Munich, Germany
Approaches to Identify Crucial miRNA Mechanisms of Action

Tuesday, March 28 | 5:00PM - 7:00PM
Novel Approaches in RNA Detection and Networks
Room: Grays Peak

Speaker 4 of 6
Arthur A. Levin, Avidity Biosciences, USA
Toxicological Considerations in Oligonucleotide Therapeutics Development

Tuesday, March 28 | 5:00PM - 7:00PM
Novel Approaches in RNA Detection and Networks
Room: Grays Peak

Speaker 5 of 6
Anne Katrine Johansen, Hubrecht Institute, Netherlands
Short Talk: CRISPR/Cas9-based Postnatal Gene Editing to Study Cardiac Gene Function in vivo

Tuesday, March 28 | 5:00PM - 7:00PM
Novel Approaches in RNA Detection and Networks
Room: Grays Peak

Speaker 6 of 6
Prabhu Mathiyalagan, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Dynamic Regulation of m6A RNA methylation is a Novel Remodeling Mechanism of the Ischemic Heart

Tuesday, March 28 | 5:00PM - 7:00PM
Gene Regulatory Mechanisms
This session is from Cardiac Development
Room: Longs Peak

Speaker 1 of 5
* Laurie A. Boyer, Massachusetts Institute of Technology, USA


Tuesday, March 28 | 5:00PM - 7:00PM
Gene Regulatory Mechanisms
This session is from Cardiac Development
Room: Longs Peak

Speaker 2 of 5
Vincent M. Christoffels, Academic Medical Center, Netherlands
Transcriptional Regulation of the Electrical Activity Pattern of the Heart


Tuesday, March 28 | 5:00PM - 7:00PM
Gene Regulatory Mechanisms
This session is from Cardiac Development
Room: Longs Peak

Speaker 3 of 5
Benoit G. Bruneau, Gladstone Institutes, USA
Transcriptional Regulation of Heart Development


Tuesday, March 28 | 5:00PM - 7:00PM
Gene Regulatory Mechanisms
This session is from Cardiac Development
Room: Longs Peak

Speaker 4 of 5
Brian L. Black, University of California, San Francisco, USA
Cooperative Activation of Cardiac Transcription through Myocardin Bridging of Paired MEF2 Sites


Tuesday, March 28 | 5:00PM - 7:00PM
Gene Regulatory Mechanisms
This session is from Cardiac Development
Room: Longs Peak

Speaker 5 of 5
Rangarajan Nadadur, University of Chicago, USA
Short Talk: Differential Enhancer Transcription Defines a Disease-Associated Gene Regulatory Network


Tuesday, March 28 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Tuesday, March 28 | 7:30PM - 10:00PM
Poster Session 2
Room: Red Cloud/Shavano/Torreys


Wednesday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
Room: Grays Peak

Speaker 1 of 8
* Stefan Engelhardt, Technical University of Munich, Germany

Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
Room: Grays Peak

Speaker 2 of 8
Gerald W. Dorn, II, Washington University School of Medicine, USA
Orchestration of Smoothened/Hedgehog/GATA Transcriptional Activity by GRKs 2, 5, and 6 in Developing Mouse Hearts

Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
Room: Grays Peak

Speaker 3 of 8
Yibin Wang, University of California, Los Angeles, David Geffen School of Medicine, USA
A lncRNA-Dependent Epigenetic Check-Point for Cardiac Hypertrophy and Remodeling

Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
Room: Grays Peak


Coffee Break

Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
Room: Grays Peak

Speaker 5 of 8
Thomas Thum, Medical School Hannover, Germany
lncRNAs in Cardiac Remodeling

Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
Room: Grays Peak

Speaker 6 of 8
Venkata Naga Srikanth Garikipati, Temple University, USA
Short Talk: Long Noncoding Circular RNA mmu_circ_008396 Modulates Cardiac Repair After Myocardial Infarction

Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
Room: Grays Peak

Speaker 7 of 8
Da-Zhi Wang, Children's Hospital Boston, USA
Short Talk: Genome-Wide Identification and Characterization of Cardiac Hypertrophy-Related Long Noncoding RNAs

Wednesday, March 29 | 8:00AM - 11:00AM
Non-Coding RNAs Going Looooong . . .
Room: Grays Peak

Speaker 8 of 8
Samir Ounzain, HAYA Therapeutics, Switzerland
Short Talk: Transposable Elements Contribute to the Functional and Regulatory Characteristics of Cardiovascular lncRNAs

Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
This session is from Cardiac Development
Room: Longs Peak

Speaker 1 of 7
* Vincent M. Christoffels, Academic Medical Center, Netherlands


Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
This session is from Cardiac Development
Room: Longs Peak

Speaker 2 of 7
Christine E. Seidman, Harvard Medical School, USA
Steps and Missteps in Building the Heart


Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
This session is from Cardiac Development
Room: Longs Peak

Speaker 3 of 7
Ivan P. Moskowitz, University of Chicago, USA
A Timing Switch for Cardiac Progenitor Differentiation


Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
This session is from Cardiac Development
Room: Longs Peak


Coffee Break


Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
This session is from Cardiac Development
Room: Longs Peak

Speaker 5 of 7
William T. Pu, Children's Hospital, Harvard Medical School, USA
iPSC-CM Models of Congenital Heart Disease


Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
This session is from Cardiac Development
Room: Longs Peak

Speaker 6 of 7
Richard P. Harvey, University of New South Wales, Victor Chang Cardiac Research Institute, Australia
Transcriptional Targets and Off-Targets in Congenital Heart Disease


Wednesday, March 29 | 8:00AM - 11:00AM
Congenital Heart Disease: Genes and Pathways
This session is from Cardiac Development
Room: Longs Peak

Speaker 7 of 7
Zhe Han, Children's National Health System, USA
Short Talk: High Throughput in vivo Functional Validation of Candidate Congenital Heart Disease Genes in Drosophila


Wednesday, March 29 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, March 29 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Wednesday, March 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Wednesday, March 29 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
Room: Grays Peak

Speaker 1 of 8
* Yibin Wang, University of California, Los Angeles, David Geffen School of Medicine, USA

Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
Room: Grays Peak

Speaker 2 of 8
* Patrick Most, University of Heidelberg, Germany

Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
Room: Grays Peak

Speaker 3 of 8
Rusty Montgomery, miRagen Therapeutics, Inc., USA
Pharmacokinetic/Dynamic Aspects of Oligonucleotide Therapeutics

Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
Room: Grays Peak

Speaker 4 of 8
Christian Kupatt, Technical University Munich, Germany
Micro-RNAs based Therapeutics in Porcine Cardiac Disease Models

Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
Room: Grays Peak

Speaker 5 of 8
Rabea Hinkel, Klinikum rechts der Isar, TUM, Germany
Short Talk: Cardio-Protective Potential of miR-92a Inhibition in Myocardial Ischemia

Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
Room: Grays Peak

Speaker 6 of 8
Dongtak Jeong, Ichan School of Medicine at Mount Sinai, USA
Short Talk: AAV9 miR-25 Tough Decoy Transfer Improves Cardiac Function in HF and Aged MDX/UTRN KO Mice

Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
Room: Grays Peak

Speaker 7 of 8
Adam E. Mullick, Ionis Pharmaceuticals, Inc., USA
Short Talk: Characterization of Cardiac Gen 2.5 Antisense Oligonucleotide Activity

Wednesday, March 29 | 5:00PM - 7:15PM
Preclinical Approaches Using RNA Therapeutics
Room: Grays Peak

Speaker 8 of 8
Deepak Prabhu Ramanujam, Institute of Pharmakologie und Toxikologie, Technische Universitaet Muenchen, Germany
Short Talk: Inhibition of microRNA-21 Prevents Myocardial Remodeling in a Pig Model of Ischemia/Reperfusion Injury

Wednesday, March 29 | 5:00PM - 7:00PM
Mechanisms of Cardiac Growth and Morphogenesis
This session is from Cardiac Development
Room: Longs Peak

Speaker 1 of 5
* Caroline E. Burns, Harvard Medical School, Boston Children's Hospital, USA


Wednesday, March 29 | 5:00PM - 7:00PM
Mechanisms of Cardiac Growth and Morphogenesis
This session is from Cardiac Development
Room: Longs Peak

Speaker 2 of 5
Anthony B. Firulli, Wells Center for Pediatrics Research, USA
Characterization of a Hand1 Left Ventricular Enhancer and Development of a Left Ventricular Specific Cre Driver


Wednesday, March 29 | 5:00PM - 7:00PM
Mechanisms of Cardiac Growth and Morphogenesis
This session is from Cardiac Development
Room: Longs Peak

Speaker 3 of 5
Katherine E. Yutzey, Cincinnati Children's Hospital Medical Center, USA
Developmental Mechanisms of Heart Valve Disease


Wednesday, March 29 | 5:00PM - 7:00PM
Mechanisms of Cardiac Growth and Morphogenesis
This session is from Cardiac Development
Room: Longs Peak

Speaker 4 of 5
James F. Martin, Baylor College of Medicine, USA
The Hippo Pathway in Heart Development and Regeneration


Wednesday, March 29 | 5:00PM - 7:00PM
Mechanisms of Cardiac Growth and Morphogenesis
This session is from Cardiac Development
Room: Longs Peak

Speaker 5 of 5
Daniela Panakova, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Planar Cell Polarity Pathway Links Mechanosensitive Feedback between Cardiac Remodeling and Muscle Differentiation


Wednesday, March 29 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Wednesday, March 29 | 7:30PM - 10:00PM
Poster Session 3
Room: Red Cloud/Shavano/Torreys


Thursday, March 30 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak

Speaker 1 of 7
* Mauro Giacca, International Center for Genetic Engineering, Italy

Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak

Speaker 2 of 7
Deepak Srivastava, Gladstone Institutes, USA
Cellular Reprogramming Approaches for Cardiovascular Disease


Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak

Speaker 3 of 7
Nadia Mercader, Institut of Anatomy, University of Bern, Switzerland
Plasticity of Cardiomyocyte Fate during Heart Regeneration in Zebrafish

Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak


Coffee Break

Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak

Speaker 5 of 7
Leon Johannes De Windt, Maastricht University, Netherlands
Fetal miRNAs Play Large at Heart Failure

Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak

Speaker 6 of 7
Andrew H. Baker, University of Edinburgh, UK
Non Coding RNA Therapeutics in Cardiovascular Pathophysiology

Thursday, March 30 | 8:00AM - 11:00AM
Mechanisms of Cardiovascular Regeneration (Joint)
Room: Grays/Longs Peak

Speaker 7 of 7
Chen Gao, University of California, Los Angeles, USA
Short Talk: Cytosolic RBFox1 In Cardiac Fibrosis Regulation

Thursday, March 30 | 11:00AM - 2:30PM
On Own for Lunch


Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 1 of 10
* Masaki Ieda, Keio University School of Medicine, Japan

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 2 of 10
* Eva van Rooij, Hubrecht Institute, Netherlands

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 3 of 10
Monika M. Gladka, Hubrecht Institute, Netherlands
Zeb2 Protects the Heart from Ischemic Damage


Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 4 of 10
Ajit Magadum, Icahn School of Medicine, Mount Sinai Hospital, USA
Cardiomyocyte-Specific Expression of Cell Cycle Inducer modRNA Induces Cardiac Regeneration

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 5 of 10
Shin Watanabe, Icahn School of Medicine at Mount Sinai, USA
miR-146a Regulates Cardiac Function by Targeting SUMO1/SERCA2a Pathway

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 6 of 10
Lina A. Shehadeh, University of Miami Miller School of Medicine, USA
Osteopontin RNA Aptamer Can Prevent and Reverse Pressure Overload-Induced Heart Failure

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 7 of 10
C. Geoffrey Burns, Harvard Medical School, Massachusetts General Hospital, USA
Cardiomyocyte Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 8 of 10
Honghai Liu, Children's Hospital of Pittsburgh of UPMC, USA
Repression of Epithelial Cell Transforming 2 (Ect2) Induces Binucleation of Cardiomyocytes

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 9 of 10
Thomas J. Cahill, University of Oxford, UK
Macrophages Activate Distinct Programs of Regeneration and Scar Formation to Direct Repair following Myocardial Infarction

Thursday, March 30 | 2:30PM - 4:30PM
Workshop 2: Cardiovascular Repair Mechanisms (Joint)
Room: Longs Peak

Speaker 10 of 10
Hamid el Azzouzi, Maastricht University, Netherlands
Targeted Deletion of ADAR1 in the Adult Heart Causes Severe Cardiac Dysfunction and Increased Lethality

Thursday, March 30 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 30 | 5:00PM - 6:45PM
RNA Therapeutics in Clinical Translation
Room: Grays Peak

Speaker 1 of 4
* Wolfram H. Zimmermann, University Medical Center Göttingen, Germany

Thursday, March 30 | 5:00PM - 6:45PM
RNA Therapeutics in Clinical Translation
Room: Grays Peak

Speaker 2 of 4
Roger J. Hajjar, Mount Sinai School of Medicine, USA
Gene Therapy and Genome Editing for Heart Failure


Thursday, March 30 | 5:00PM - 6:45PM
RNA Therapeutics in Clinical Translation
Room: Grays Peak

Speaker 3 of 4
Patrick Most, University of Heidelberg, Germany
Development of Nucleic-Acid Therapeutics for Cardiac and Vascular Disorder Treatment

Thursday, March 30 | 5:00PM - 6:45PM
RNA Therapeutics in Clinical Translation
Room: Grays Peak

Speaker 4 of 4
Mauro Giacca, International Center for Genetic Engineering, Italy
Small RNA Therapy for Cardiac Regeneration

Thursday, March 30 | 5:00PM - 6:45PM
Modeling Human Heart Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 1 of 4
* Benoit G. Bruneau, Gladstone Institutes, USA


Thursday, March 30 | 5:00PM - 6:45PM
Modeling Human Heart Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 2 of 4
Christine L. Mummery, Leiden University Medical Center, Netherlands
Developmental Patterning of Human Pluripotent Stem Cells: From Beating Cardiomycoytes to Heart Disease Models


Thursday, March 30 | 5:00PM - 6:45PM
Modeling Human Heart Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 3 of 4
Charles E. Murry, University of Washington, USA
Networks Underlying Human Cardiovascular Differentiation


Thursday, March 30 | 5:00PM - 6:45PM
Modeling Human Heart Development
This session is from Cardiac Development
Room: Longs Peak

Speaker 4 of 4
Gordon M. Keller, University Health Network, MaRS Centre, Canada
Modeling Cardiovascular Development with Human Pluripotent Stem Cells


Thursday, March 30 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Grays Peak


Thursday, March 30 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Cardiac Development
Room: Longs Peak


Thursday, March 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Thursday, March 30 | 8:00PM - 11:00PM
Entertainment
Room: Red Cloud/Shavano/Torreys
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 30 | 8:00PM - 11:00PM
Cash Bar
Room: Red Cloud/Shavano/Torreys


Friday, March 31 | 10:25AM - 10:25AM
Departure


*Session Chair.