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Web Desc
RNA-Based Approaches in Cardiovascular Disease joint with Molecular Mechanisms of Heart Development Organizer(s): Thomas Thum and Roger J. Hajjar Date: March 26 - 30, 2017 Location: Keystone Resort, Keystone, CO, USA Sponsored by AstraZeneca Summary of Meeting: Cardiac diseases are the leading cause of death worldwide. RNA-based mechanisms and therapeutic approaches are emerging fields in cardiovascular science. This meeting will present and discuss latest developments using both coding RNA and noncoding RNA (such as microRNAs, long noncoding RNAs and circular RNAs) -based approaches to better understand and develop new therapeutic strategies for cardiac diseases. Attendees will benefit from workshops, specific sessions and industrial perspectives covering everything from basic science to clinical translation employing RNA therapeutics in cardiovascular medicine. Scholarship Deadline: November 30 2016 Discounted Abstract Deadline: November 30 2016 Abstract Deadline: January 11 2017 Discounted Registration Deadline: January 26 2017 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge the generous grant for this conference provided by: National Heart, Lung, and Blood Institute (NHLBI) Grant No. 1R13HL135954-01 Funding for this conference was made possible (in part) by 1R13HL135954-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

RNA-Based Approaches in Cardiovascular Disease

joint with Molecular Mechanisms of Heart Development

Organizer(s): Thomas Thum and Roger J. Hajjar

Date: March 26 - 30, 2017
Location: Keystone Resort, Keystone, CO, USA

Program


Sunday, March 26 \| 4:00PM - 8:00PM Arrival and Registration Room: Longs Peak Foyer
Sunday, March 26 \| 6:00PM - 8:00PM Welcome Mixer Room: Longs Peak Foyer No registration fees are used to fund alcohol served at this function.
Monday, March 27 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Monday, March 27 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Grays/Longs Peak Speaker 1 of 3 * Benoit G. Bruneau, Gladstone Institutes, USA
Monday, March 27 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Grays/Longs Peak Speaker 2 of 3 * Thomas Thum, Medical School Hannover, Germany
Monday, March 27 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Grays/Longs Peak Speaker 3 of 3 Eric N. Olson, University of Texas Southwestern Medical Center, USA Following the Heart
Monday, March 27 \| 9:00AM - 11:15AM Common RNA-Based Mechanisms in Cardiovascular Development an d Pathology (Joint) Room: Grays/Longs Peak Speaker 1 of 7 * Benoit G. Bruneau, Gladstone Institutes, USA
Monday, March 27 \| 9:00AM - 11:15AM Common RNA-Based Mechanisms in Cardiovascular Development an d Pathology (Joint) Room: Grays/Longs Peak Speaker 2 of 7 * Thomas Thum, Medical School Hannover, Germany
Monday, March 27 \| 9:00AM - 11:15AM Common RNA-Based Mechanisms in Cardiovascular Development an d Pathology (Joint) Room: Grays/Longs Peak Speaker 3 of 7 Stefanie Dimmeler, University of Frankfurt, Germany Non-coding RNAs in Cardiovascular Repair and Aging
Monday, March 27 \| 9:00AM - 11:15AM Common RNA-Based Mechanisms in Cardiovascular Development an d Pathology (Joint) Room: Grays/Longs Peak Coffee Break
Monday, March 27 \| 9:00AM - 11:15AM Common RNA-Based Mechanisms in Cardiovascular Development an d Pathology (Joint) Room: Grays/Longs Peak Speaker 5 of 7 William C. Sessa, Yale University School of Medicine, USA Vascular Therapeutics Approaches using miRNAs
Monday, March 27 \| 9:00AM - 11:15AM Common RNA-Based Mechanisms in Cardiovascular Development an d Pathology (Joint) Room: Grays/Longs Peak Speaker 6 of 7 Laurie A. Boyer, Massachusetts Institute of Technology, USA Long Noncoding RNAs in Heart Development and Differentiation
Monday, March 27 \| 9:00AM - 11:15AM Common RNA-Based Mechanisms in Cardiovascular Development an d Pathology (Joint) Room: Grays/Longs Peak Speaker 7 of 7 Tilman Ziegler, Klinikum rechts der Isar der TU München, Germany Short Talk: LNA Mediated Inhibition of miR-132 Prevents Hypertrophy Induced Cardiomyopathy in Pigs
Monday, March 27 \| 11:15AM - 2:30PM On Own for Lunch
Monday, March 27 \| 11:15AM - 1:00PM Poster Setup Room: Red Cloud/Shavano/Torreys
Monday, March 27 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano/Torreys
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Basic and Novel Tools for RNA Research Room: Grays Peak Speaker 1 of 6 * Carlos Fernandez-Hernando, Yale School of Medicine, USA
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Basic and Novel Tools for RNA Research Room: Grays Peak Speaker 2 of 6 * Leon Johannes De Windt, Maastricht University, Netherlands
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Basic and Novel Tools for RNA Research Room: Grays Peak Speaker 3 of 6 Esther E. Creemers, Academic Medical Center, Netherlands Circular RNA Profiling and Implications for Cardiac Disease
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Basic and Novel Tools for RNA Research Room: Grays Peak Speaker 4 of 6 Mark Mercola, Stanford University, USA High Throughput Screening as a Massive Omics Approach to Understand the Heart
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Basic and Novel Tools for RNA Research Room: Grays Peak Speaker 5 of 6 Lior Zangi, Icahn School of Medicine at Mount Sinai, USA Gene Therapy Approach for Cardiac Regeneration using Modified mRNA
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Basic and Novel Tools for RNA Research Room: Grays Peak Speaker 6 of 6 Cristina Espinosa-Diez, Oregon Health and Science University, USA A MicroRNA Regulated Incoherent Feedforward Loop Drives Vascular Senescence
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Gene Regulatory Mechanisms This session is from Cardiac Development Room: Longs Peak Speaker 1 of 7 * Eric Small, University of Rochester, USA
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Gene Regulatory Mechanisms This session is from Cardiac Development Room: Longs Peak Speaker 2 of 7 Nicole Schlüßler, Goethe University Frankfurt, Germany A LncRNA Locus in the Genomic Region of Hand2 is Essential for Cardiac Development
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Gene Regulatory Mechanisms This session is from Cardiac Development Room: Longs Peak Speaker 3 of 7 Alexandre R. Colas, Sanford-Burnham Medical Research Institute, USA Id Genes Are Essential For Early Heart Formation
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Gene Regulatory Mechanisms This session is from Cardiac Development Room: Longs Peak Speaker 4 of 7 Sunil K. Verma, University of Texas Medical Branch, USA Role of the RNA Binding Protein Rbfox2 in Hypoplastic Left Heart Syndrome
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Gene Regulatory Mechanisms This session is from Cardiac Development Room: Longs Peak Speaker 5 of 7 Christian Mosimann, University of Zürich, Switzerland An Ancient Regulatory Program Controls the Emergence of Cardiogenic Lateral Plate Mesoderm
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Gene Regulatory Mechanisms This session is from Cardiac Development Room: Longs Peak Speaker 6 of 7 Li Qian, University of North Carolina at Chapel Hill, USA Single Cell Transcriptomics Reveals a Deterministic Trajectory of Cell Fate Conversion during Direct Cardiac Reprogramming
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Gene Regulatory Mechanisms This session is from Cardiac Development Room: Longs Peak Speaker 7 of 7 Min Zhang, Shanghai Children's Medical Center, China Atrial Fibrillation-Associated Functional Element Regulates Pitx2 Expression via CTCF-Mediated Long-Range Interaction
Monday, March 27 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, March 27 \| 5:00PM - 7:15PM Fundamentals in RNA Diagnostics and Paracrine Effects Room: Grays Peak Speaker 1 of 8 * Manuel Mayr, King's College, University of London, UK
Monday, March 27 \| 5:00PM - 7:15PM Fundamentals in RNA Diagnostics and Paracrine Effects Room: Grays Peak Speaker 2 of 8 * Susmita Sahoo, Icahn School of Medicine at Mount Sinai, USA
Monday, March 27 \| 5:00PM - 7:15PM Fundamentals in RNA Diagnostics and Paracrine Effects Room: Grays Peak Speaker 3 of 8 Carlos Fernandez-Hernando, Yale School of Medicine, USA Noncoding RNAs as Paracrine Players in Vascular Inflammation and Lipid Metabolism
Monday, March 27 \| 5:00PM - 7:15PM Fundamentals in RNA Diagnostics and Paracrine Effects Room: Grays Peak Speaker 4 of 8 Denise Hilfiker-Kleiner, Medizinische Hochschule Hannover, Germany Pathophysiology of Peripartum Cardiomyopathy Links Prolactin to the PAI-1/uPAR System: Modulation of NF-kB Signaling and miR146a as Therapeutic Options
Monday, March 27 \| 5:00PM - 7:15PM Fundamentals in RNA Diagnostics and Paracrine Effects Room: Grays Peak Speaker 5 of 8 Paula da Costa Martins, Maastricht University, Netherlands Short Talk: Cardiomyocyte-Derived Exosomes Mediate Pathological Cardiac Microvascular Remodeling
Monday, March 27 \| 5:00PM - 7:15PM Fundamentals in RNA Diagnostics and Paracrine Effects Room: Grays Peak Speaker 6 of 8 Yuri D'Alessandra, Centro Cardiologico Monzino, Italy Short Talk: Circulating MicroRNAs as Biomarkers of Long-Term Doxorubicin-Induced Cardiotoxicity
Monday, March 27 \| 5:00PM - 7:15PM Fundamentals in RNA Diagnostics and Paracrine Effects Room: Grays Peak Speaker 7 of 8 Stefanie Novakowski, University of British Columbia, Canada Short Talk: Engineering Platelets for the Delivery of RNA
Monday, March 27 \| 5:00PM - 7:15PM Fundamentals in RNA Diagnostics and Paracrine Effects Room: Grays Peak Speaker 8 of 8 Christa L. Trexler, University of Colorado Boulder, USA Short Talk: Cardiomyocyte Function and Gene Expression are Influenced by Biological Sex
Monday, March 27 \| 5:00PM - 7:00PM Cardiac Lineages This session is from Cardiac Development Room: Longs Peak Speaker 1 of 5 * Kristy Red-Horse, Stanford University, USA
Monday, March 27 \| 5:00PM - 7:00PM Cardiac Lineages This session is from Cardiac Development Room: Longs Peak Speaker 2 of 5 Margaret E. Buckingham, Institut Pasteur, France Cardiac Cell Lineages and the Second Heart Field
Monday, March 27 \| 5:00PM - 7:00PM Cardiac Lineages This session is from Cardiac Development Room: Longs Peak Speaker 3 of 5 Lionel Christiaen, New York University, USA Regulation of Cardiopharyngeal Multipotency and Early Fate Specification in a Simple Chordate
Monday, March 27 \| 5:00PM - 7:00PM Cardiac Lineages This session is from Cardiac Development Room: Longs Peak Speaker 4 of 5 Caroline E. Burns, Harvard Medical School, Boston Children's Hospital, USA Development of the Cardiopharyngeal Lineage in Zebrafish
Monday, March 27 \| 5:00PM - 7:00PM Cardiac Lineages This session is from Cardiac Development Room: Longs Peak Speaker 5 of 5 Nicole Dubois, Icahn School of Medicine at Mount Sinai, USA Short Talk: Foxa2 Marks a Ventricular Progenitor Population during Heart Development
Monday, March 27 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Monday, March 27 \| 7:30PM - 10:00PM Poster Session 1 Room: Red Cloud/Shavano/Torreys
Tuesday, March 28 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Tuesday, March 28 \| 8:00AM - 8:45AM Keynote Address Room: Grays Peak Speaker 1 of 3 * Roger J. Hajjar, Mount Sinai School of Medicine, USA
Tuesday, March 28 \| 8:00AM - 8:45AM Keynote Address Room: Grays Peak Speaker 2 of 3 * Gerald W. Dorn, II, Washington University School of Medicine, USA
Tuesday, March 28 \| 8:00AM - 8:45AM Keynote Address Room: Grays Peak Speaker 3 of 3 Manuel Mayr, King's College, University of London, UK A Systems Biology Approach: Circulating Noncoding RNAs as Innovative Diagnostic and Prognostic Markers of Cardiovascular Disease
Tuesday, March 28 \| 8:00AM - 11:00AM Epicardium and Coronaries This session is from Cardiac Development Room: Longs Peak Speaker 1 of 7 * Kelly Smith, University of Queensland, Australia
Tuesday, March 28 \| 8:00AM - 11:00AM Epicardium and Coronaries This session is from Cardiac Development Room: Longs Peak Speaker 2 of 7 Kristy Red-Horse, Stanford University, USA Cell Fate Decisions during Coronary Artery Development
Tuesday, March 28 \| 8:00AM - 11:00AM Epicardium and Coronaries This session is from Cardiac Development Room: Longs Peak Speaker 3 of 7 Kenneth D. Poss, Duke University Medical Center, USA Cardiac Regeneration
Tuesday, March 28 \| 8:00AM - 11:00AM Epicardium and Coronaries This session is from Cardiac Development Room: Longs Peak Coffee Break
Tuesday, March 28 \| 8:00AM - 11:00AM Epicardium and Coronaries This session is from Cardiac Development Room: Longs Peak Speaker 5 of 7 Bin Zhou, Albert Einstein College of Medicine, USA Developmental Mechanisms of Coronary Artery Formation
Tuesday, March 28 \| 8:00AM - 11:00AM Epicardium and Coronaries This session is from Cardiac Development Room: Longs Peak Speaker 6 of 7 Paul R. Riley, University of Oxford, UK Developmental Programming of the Cardiac Lymphatics
Tuesday, March 28 \| 8:00AM - 11:00AM Epicardium and Coronaries This session is from Cardiac Development Room: Longs Peak Speaker 7 of 7 Michael A. Trembley, University of Rochester Medical Center, USA Short Talk: Novel Mechanisms of Epicardial-Derived Cell Mobilization
Tuesday, March 28 \| 8:45AM - 12:00PM Noncoding RNA Therapeutics: What Have We Learned? Room: Grays Peak Speaker 1 of 9 * Roger J. Hajjar, Mount Sinai School of Medicine, USA
Tuesday, March 28 \| 8:45AM - 12:00PM Noncoding RNA Therapeutics: What Have We Learned? Room: Grays Peak Speaker 2 of 9 * Gerald W. Dorn, II, Washington University School of Medicine, USA
Tuesday, March 28 \| 8:45AM - 12:00PM Noncoding RNA Therapeutics: What Have We Learned? Room: Grays Peak Speaker 3 of 9 Susmita Sahoo, Icahn School of Medicine at Mount Sinai, USA Exosomes as a Diagnostic and Therapeutic Tool in Cardiovascular Disease
Tuesday, March 28 \| 8:45AM - 12:00PM Noncoding RNA Therapeutics: What Have We Learned? Room: Grays Peak Coffee Break
Tuesday, March 28 \| 8:45AM - 12:00PM Noncoding RNA Therapeutics: What Have We Learned? Room: Grays Peak Speaker 5 of 9 Eva van Rooij, Hubrecht Institute, Netherlands Advances in Targeting miRNAs in the Heart
Tuesday, March 28 \| 8:45AM - 12:00PM Noncoding RNA Therapeutics: What Have We Learned? Room: Grays Peak Speaker 6 of 9 Gianluigi Condorelli, Humanitas University, Italy Chheaf1: A Novel lncRNA Regulating Cardiac Hypertrophy and Failure
Tuesday, March 28 \| 8:45AM - 12:00PM Noncoding RNA Therapeutics: What Have We Learned? Room: Grays Peak Speaker 7 of 9 Elizabeth M. McNally, Northwestern University, USA Targeting Muscular Dystrophy
Tuesday, March 28 \| 8:45AM - 12:00PM Noncoding RNA Therapeutics: What Have We Learned? Room: Grays Peak Speaker 8 of 9 Robin Verjans, Maastricht University, Netherlands Short Talk: Downregulation of the microRNA-221/222 Family Upon Heart Failure Contributes to Adverse Cardiac Fibrotic Remodeling
Tuesday, March 28 \| 8:45AM - 12:00PM Noncoding RNA Therapeutics: What Have We Learned? Room: Grays Peak Speaker 9 of 9 Christine Wahlquist, Stanford University, USA Short Talk: Modulation of Cardiomyocyte Physiology by Stretch-Induced miRNAs
Tuesday, March 28 \| 12:00PM - 5:00PM On Own for Lunch
Tuesday, March 28 \| 12:00PM - 1:00PM Poster Setup Room: Red Cloud/Shavano/Torreys
Tuesday, March 28 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano/Torreys
Tuesday, March 28 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, March 28 \| 5:00PM - 7:00PM Novel Approaches in RNA Detection and Networks Room: Grays Peak Speaker 1 of 6 * Gianluigi Condorelli, Humanitas University, Italy
Tuesday, March 28 \| 5:00PM - 7:00PM Novel Approaches in RNA Detection and Networks Room: Grays Peak Speaker 2 of 6 * Christian Kupatt, Technical University Munich, Germany
Tuesday, March 28 \| 5:00PM - 7:00PM Novel Approaches in RNA Detection and Networks Room: Grays Peak Speaker 3 of 6 Stefan Engelhardt, Technical University of Munich, Germany Approaches to Identify Crucial miRNA Mechanisms of Action
Tuesday, March 28 \| 5:00PM - 7:00PM Novel Approaches in RNA Detection and Networks Room: Grays Peak Speaker 4 of 6 Arthur A. Levin, Avidity Biosciences, USA Toxicological Considerations in Oligonucleotide Therapeutics Development
Tuesday, March 28 \| 5:00PM - 7:00PM Novel Approaches in RNA Detection and Networks Room: Grays Peak Speaker 5 of 6 Anne Katrine Johansen, Hubrecht Institute, Netherlands Short Talk: CRISPR/Cas9-based Postnatal Gene Editing to Study Cardiac Gene Function in vivo
Tuesday, March 28 \| 5:00PM - 7:00PM Novel Approaches in RNA Detection and Networks Room: Grays Peak Speaker 6 of 6 Prabhu Mathiyalagan, Icahn School of Medicine at Mount Sinai, USA Short Talk: Dynamic Regulation of m6A RNA methylation is a Novel Remodeling Mechanism of the Ischemic Heart
Tuesday, March 28 \| 5:00PM - 7:00PM Gene Regulatory Mechanisms This session is from Cardiac Development Room: Longs Peak Speaker 1 of 5 * Laurie A. Boyer, Massachusetts Institute of Technology, USA
Tuesday, March 28 \| 5:00PM - 7:00PM Gene Regulatory Mechanisms This session is from Cardiac Development Room: Longs Peak Speaker 2 of 5 Vincent M. Christoffels, Academic Medical Center, Netherlands Transcriptional Regulation of the Electrical Activity Pattern of the Heart
Tuesday, March 28 \| 5:00PM - 7:00PM Gene Regulatory Mechanisms This session is from Cardiac Development Room: Longs Peak Speaker 3 of 5 Benoit G. Bruneau, Gladstone Institutes, USA Transcriptional Regulation of Heart Development
Tuesday, March 28 \| 5:00PM - 7:00PM Gene Regulatory Mechanisms This session is from Cardiac Development Room: Longs Peak Speaker 4 of 5 Brian L. Black, University of California, San Francisco, USA Cooperative Activation of Cardiac Transcription through Myocardin Bridging of Paired MEF2 Sites
Tuesday, March 28 \| 5:00PM - 7:00PM Gene Regulatory Mechanisms This session is from Cardiac Development Room: Longs Peak Speaker 5 of 5 Rangarajan Nadadur, University of Chicago, USA Short Talk: Differential Enhancer Transcription Defines a Disease-Associated Gene Regulatory Network
Tuesday, March 28 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Tuesday, March 28 \| 7:30PM - 10:00PM Poster Session 2 Room: Red Cloud/Shavano/Torreys
Wednesday, March 29 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Wednesday, March 29 \| 8:00AM - 11:00AM Non-Coding RNAs Going Looooong . . . Room: Grays Peak Speaker 1 of 8 * Stefan Engelhardt, Technical University of Munich, Germany
Wednesday, March 29 \| 8:00AM - 11:00AM Non-Coding RNAs Going Looooong . . . Room: Grays Peak Speaker 2 of 8 Gerald W. Dorn, II, Washington University School of Medicine, USA Orchestration of Smoothened/Hedgehog/GATA Transcriptional Activity by GRKs 2, 5, and 6 in Developing Mouse Hearts
Wednesday, March 29 \| 8:00AM - 11:00AM Non-Coding RNAs Going Looooong . . . Room: Grays Peak Speaker 3 of 8 Yibin Wang, University of California, Los Angeles, David Geffen School of Medicine, USA A lncRNA-Dependent Epigenetic Check-Point for Cardiac Hypertrophy and Remodeling
Wednesday, March 29 \| 8:00AM - 11:00AM Non-Coding RNAs Going Looooong . . . Room: Grays Peak Coffee Break
Wednesday, March 29 \| 8:00AM - 11:00AM Non-Coding RNAs Going Looooong . . . Room: Grays Peak Speaker 5 of 8 Thomas Thum, Medical School Hannover, Germany lncRNAs in Cardiac Remodeling
Wednesday, March 29 \| 8:00AM - 11:00AM Non-Coding RNAs Going Looooong . . . Room: Grays Peak Speaker 6 of 8 Venkata Naga Srikanth Garikipati, Temple University, USA Short Talk: Long Noncoding Circular RNA mmu_circ_008396 Modulates Cardiac Repair After Myocardial Infarction
Wednesday, March 29 \| 8:00AM - 11:00AM Non-Coding RNAs Going Looooong . . . Room: Grays Peak Speaker 7 of 8 Da-Zhi Wang, Children's Hospital Boston, USA Short Talk: Genome-Wide Identification and Characterization of Cardiac Hypertrophy-Related Long Noncoding RNAs
Wednesday, March 29 \| 8:00AM - 11:00AM Non-Coding RNAs Going Looooong . . . Room: Grays Peak Speaker 8 of 8 Samir Ounzain, HAYA Therapeutics, Switzerland Short Talk: Transposable Elements Contribute to the Functional and Regulatory Characteristics of Cardiovascular lncRNAs
Wednesday, March 29 \| 8:00AM - 11:00AM Congenital Heart Disease: Genes and Pathways This session is from Cardiac Development Room: Longs Peak Speaker 1 of 7 * Vincent M. Christoffels, Academic Medical Center, Netherlands
Wednesday, March 29 \| 8:00AM - 11:00AM Congenital Heart Disease: Genes and Pathways This session is from Cardiac Development Room: Longs Peak Speaker 2 of 7 Christine E. Seidman, Harvard Medical School, USA Steps and Missteps in Building the Heart
Wednesday, March 29 \| 8:00AM - 11:00AM Congenital Heart Disease: Genes and Pathways This session is from Cardiac Development Room: Longs Peak Speaker 3 of 7 Ivan P. Moskowitz, University of Chicago, USA A Timing Switch for Cardiac Progenitor Differentiation
Wednesday, March 29 \| 8:00AM - 11:00AM Congenital Heart Disease: Genes and Pathways This session is from Cardiac Development Room: Longs Peak Coffee Break
Wednesday, March 29 \| 8:00AM - 11:00AM Congenital Heart Disease: Genes and Pathways This session is from Cardiac Development Room: Longs Peak Speaker 5 of 7 William T. Pu, Children's Hospital, Harvard Medical School, USA iPSC-CM Models of Congenital Heart Disease
Wednesday, March 29 \| 8:00AM - 11:00AM Congenital Heart Disease: Genes and Pathways This session is from Cardiac Development Room: Longs Peak Speaker 6 of 7 Richard P. Harvey, University of New South Wales, Victor Chang Cardiac Research Institute, Australia Transcriptional Targets and Off-Targets in Congenital Heart Disease
Wednesday, March 29 \| 8:00AM - 11:00AM Congenital Heart Disease: Genes and Pathways This session is from Cardiac Development Room: Longs Peak Speaker 7 of 7 Zhe Han, Children's National Health System, USA Short Talk: High Throughput in vivo Functional Validation of Candidate Congenital Heart Disease Genes in Drosophila
Wednesday, March 29 \| 11:00AM - 5:00PM On Own for Lunch
Wednesday, March 29 \| 11:00AM - 1:00PM Poster Setup Room: Red Cloud/Shavano/Torreys
Wednesday, March 29 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano/Torreys
Wednesday, March 29 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, March 29 \| 5:00PM - 7:15PM Preclinical Approaches Using RNA Therapeutics Room: Grays Peak Speaker 1 of 8 * Yibin Wang, University of California, Los Angeles, David Geffen School of Medicine, USA
Wednesday, March 29 \| 5:00PM - 7:15PM Preclinical Approaches Using RNA Therapeutics Room: Grays Peak Speaker 2 of 8 * Patrick Most, University of Heidelberg, Germany
Wednesday, March 29 \| 5:00PM - 7:15PM Preclinical Approaches Using RNA Therapeutics Room: Grays Peak Speaker 3 of 8 Rusty Montgomery, miRagen Therapeutics, Inc., USA Pharmacokinetic/Dynamic Aspects of Oligonucleotide Therapeutics
Wednesday, March 29 \| 5:00PM - 7:15PM Preclinical Approaches Using RNA Therapeutics Room: Grays Peak Speaker 4 of 8 Christian Kupatt, Technical University Munich, Germany Micro-RNAs based Therapeutics in Porcine Cardiac Disease Models
Wednesday, March 29 \| 5:00PM - 7:15PM Preclinical Approaches Using RNA Therapeutics Room: Grays Peak Speaker 5 of 8 Rabea Hinkel, Klinikum rechts der Isar, TUM, Germany Short Talk: Cardio-Protective Potential of miR-92a Inhibition in Myocardial Ischemia
Wednesday, March 29 \| 5:00PM - 7:15PM Preclinical Approaches Using RNA Therapeutics Room: Grays Peak Speaker 6 of 8 Dongtak Jeong, Ichan School of Medicine at Mount Sinai, USA Short Talk: AAV9 miR-25 Tough Decoy Transfer Improves Cardiac Function in HF and Aged MDX/UTRN KO Mice
Wednesday, March 29 \| 5:00PM - 7:15PM Preclinical Approaches Using RNA Therapeutics Room: Grays Peak Speaker 7 of 8 Adam E. Mullick, Ionis Pharmaceuticals, Inc., USA Short Talk: Characterization of Cardiac Gen 2.5 Antisense Oligonucleotide Activity
Wednesday, March 29 \| 5:00PM - 7:15PM Preclinical Approaches Using RNA Therapeutics Room: Grays Peak Speaker 8 of 8 Deepak Prabhu Ramanujam, Institute of Pharmakologie und Toxikologie, Technische Universitaet Muenchen, Germany Short Talk: Inhibition of microRNA-21 Prevents Myocardial Remodeling in a Pig Model of Ischemia/Reperfusion Injury
Wednesday, March 29 \| 5:00PM - 7:00PM Mechanisms of Cardiac Growth and Morphogenesis This session is from Cardiac Development Room: Longs Peak Speaker 1 of 5 * Caroline E. Burns, Harvard Medical School, Boston Children's Hospital, USA
Wednesday, March 29 \| 5:00PM - 7:00PM Mechanisms of Cardiac Growth and Morphogenesis This session is from Cardiac Development Room: Longs Peak Speaker 2 of 5 Anthony B. Firulli, Wells Center for Pediatrics Research, USA Characterization of a Hand1 Left Ventricular Enhancer and Development of a Left Ventricular Specific Cre Driver
Wednesday, March 29 \| 5:00PM - 7:00PM Mechanisms of Cardiac Growth and Morphogenesis This session is from Cardiac Development Room: Longs Peak Speaker 3 of 5 Katherine E. Yutzey, Cincinnati Children's Hospital Medical Center, USA Developmental Mechanisms of Heart Valve Disease
Wednesday, March 29 \| 5:00PM - 7:00PM Mechanisms of Cardiac Growth and Morphogenesis This session is from Cardiac Development Room: Longs Peak Speaker 4 of 5 James F. Martin, Baylor College of Medicine, USA The Hippo Pathway in Heart Development and Regeneration
Wednesday, March 29 \| 5:00PM - 7:00PM Mechanisms of Cardiac Growth and Morphogenesis This session is from Cardiac Development Room: Longs Peak Speaker 5 of 5 Daniela Panakova, Max Delbrück Center for Molecular Medicine, Germany Short Talk: Planar Cell Polarity Pathway Links Mechanosensitive Feedback between Cardiac Remodeling and Muscle Differentiation
Wednesday, March 29 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Wednesday, March 29 \| 7:30PM - 10:00PM Poster Session 3 Room: Red Cloud/Shavano/Torreys
Thursday, March 30 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Thursday, March 30 \| 8:00AM - 11:00AM Mechanisms of Cardiovascular Regeneration (Joint) Room: Grays/Longs Peak Speaker 1 of 7 * Mauro Giacca, International Center for Genetic Engineering, Italy
Thursday, March 30 \| 8:00AM - 11:00AM Mechanisms of Cardiovascular Regeneration (Joint) Room: Grays/Longs Peak Speaker 2 of 7 Deepak Srivastava, Gladstone Institutes, USA Cellular Reprogramming Approaches for Cardiovascular Disease
Thursday, March 30 \| 8:00AM - 11:00AM Mechanisms of Cardiovascular Regeneration (Joint) Room: Grays/Longs Peak Speaker 3 of 7 Nadia Mercader, Institut of Anatomy, University of Bern, Switzerland Plasticity of Cardiomyocyte Fate during Heart Regeneration in Zebrafish
Thursday, March 30 \| 8:00AM - 11:00AM Mechanisms of Cardiovascular Regeneration (Joint) Room: Grays/Longs Peak Coffee Break
Thursday, March 30 \| 8:00AM - 11:00AM Mechanisms of Cardiovascular Regeneration (Joint) Room: Grays/Longs Peak Speaker 5 of 7 Leon Johannes De Windt, Maastricht University, Netherlands Fetal miRNAs Play Large at Heart Failure
Thursday, March 30 \| 8:00AM - 11:00AM Mechanisms of Cardiovascular Regeneration (Joint) Room: Grays/Longs Peak Speaker 6 of 7 Andrew H. Baker, University of Edinburgh, UK Non Coding RNA Therapeutics in Cardiovascular Pathophysiology
Thursday, March 30 \| 8:00AM - 11:00AM Mechanisms of Cardiovascular Regeneration (Joint) Room: Grays/Longs Peak Speaker 7 of 7 Chen Gao, University of California, Los Angeles, USA Short Talk: Cytosolic RBFox1 In Cardiac Fibrosis Regulation
Thursday, March 30 \| 11:00AM - 2:30PM On Own for Lunch
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Cardiovascular Repair Mechanisms (Joint) Room: Longs Peak Speaker 1 of 10 * Masaki Ieda, Keio University School of Medicine, Japan
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Cardiovascular Repair Mechanisms (Joint) Room: Longs Peak Speaker 2 of 10 * Eva van Rooij, Hubrecht Institute, Netherlands
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Cardiovascular Repair Mechanisms (Joint) Room: Longs Peak Speaker 3 of 10 Monika M. Gladka, Hubrecht Institute, Netherlands Zeb2 Protects the Heart from Ischemic Damage
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Cardiovascular Repair Mechanisms (Joint) Room: Longs Peak Speaker 4 of 10 Ajit Magadum, Icahn School of Medicine, Mount Sinai Hospital, USA Cardiomyocyte-Specific Expression of Cell Cycle Inducer modRNA Induces Cardiac Regeneration
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Cardiovascular Repair Mechanisms (Joint) Room: Longs Peak Speaker 5 of 10 Shin Watanabe, Icahn School of Medicine at Mount Sinai, USA miR-146a Regulates Cardiac Function by Targeting SUMO1/SERCA2a Pathway
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Cardiovascular Repair Mechanisms (Joint) Room: Longs Peak Speaker 6 of 10 Lina A. Shehadeh, University of Miami Miller School of Medicine, USA Osteopontin RNA Aptamer Can Prevent and Reverse Pressure Overload-Induced Heart Failure
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Cardiovascular Repair Mechanisms (Joint) Room: Longs Peak Speaker 7 of 10 C. Geoffrey Burns, Harvard Medical School, Massachusetts General Hospital, USA Cardiomyocyte Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Cardiovascular Repair Mechanisms (Joint) Room: Longs Peak Speaker 8 of 10 Honghai Liu, Children's Hospital of Pittsburgh of UPMC, USA Repression of Epithelial Cell Transforming 2 (Ect2) Induces Binucleation of Cardiomyocytes
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Cardiovascular Repair Mechanisms (Joint) Room: Longs Peak Speaker 9 of 10 Thomas J. Cahill, University of Oxford, UK Macrophages Activate Distinct Programs of Regeneration and Scar Formation to Direct Repair following Myocardial Infarction
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Cardiovascular Repair Mechanisms (Joint) Room: Longs Peak Speaker 10 of 10 Hamid el Azzouzi, Maastricht University, Netherlands Targeted Deletion of ADAR1 in the Adult Heart Causes Severe Cardiac Dysfunction and Increased Lethality
Thursday, March 30 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, March 30 \| 5:00PM - 6:45PM RNA Therapeutics in Clinical Translation Room: Grays Peak Speaker 1 of 4 * Wolfram H. Zimmermann, University Medical Center Göttingen, Germany
Thursday, March 30 \| 5:00PM - 6:45PM RNA Therapeutics in Clinical Translation Room: Grays Peak Speaker 2 of 4 Roger J. Hajjar, Mount Sinai School of Medicine, USA Gene Therapy and Genome Editing for Heart Failure
Thursday, March 30 \| 5:00PM - 6:45PM RNA Therapeutics in Clinical Translation Room: Grays Peak Speaker 3 of 4 Patrick Most, University of Heidelberg, Germany Development of Nucleic-Acid Therapeutics for Cardiac and Vascular Disorder Treatment
Thursday, March 30 \| 5:00PM - 6:45PM RNA Therapeutics in Clinical Translation Room: Grays Peak Speaker 4 of 4 Mauro Giacca, International Center for Genetic Engineering, Italy Small RNA Therapy for Cardiac Regeneration
Thursday, March 30 \| 5:00PM - 6:45PM Modeling Human Heart Development This session is from Cardiac Development Room: Longs Peak Speaker 1 of 4 * Benoit G. Bruneau, Gladstone Institutes, USA
Thursday, March 30 \| 5:00PM - 6:45PM Modeling Human Heart Development This session is from Cardiac Development Room: Longs Peak Speaker 2 of 4 Christine L. Mummery, Leiden University Medical Center, Netherlands Developmental Patterning of Human Pluripotent Stem Cells: From Beating Cardiomycoytes to Heart Disease Models
Thursday, March 30 \| 5:00PM - 6:45PM Modeling Human Heart Development This session is from Cardiac Development Room: Longs Peak Speaker 3 of 4 Charles E. Murry, University of Washington, USA Networks Underlying Human Cardiovascular Differentiation
Thursday, March 30 \| 5:00PM - 6:45PM Modeling Human Heart Development This session is from Cardiac Development Room: Longs Peak Speaker 4 of 4 Gordon M. Keller, University Health Network, MaRS Centre, Canada Modeling Cardiovascular Development with Human Pluripotent Stem Cells
Thursday, March 30 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Grays Peak
Thursday, March 30 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) This session is from Cardiac Development Room: Longs Peak
Thursday, March 30 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Thursday, March 30 \| 8:00PM - 11:00PM Entertainment Room: Red Cloud/Shavano/Torreys Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, March 30 \| 8:00PM - 11:00PM Cash Bar Room: Red Cloud/Shavano/Torreys
Friday, March 31 \| 10:25AM - 10:25AM Departure *Session Chair.