Web Desc
Mitochondria, Metabolism and Heart
joint with Angiogenesis and Vascular Disease
Organizer(s): Junichi Sadoshima, Toren Finkel and Åsa B. Gustafsson
Date: May 08 - 12, 2017
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Supported by Bayer HealthCare Pharmaceuticals
Summary of Meeting:
Mitochondria play a central role in regulating energy metabolism, redox status and cell death. The homeostasis of mitochondrial function is maintained by multiple mechanisms, collectively called mitochondrial quality control mechanisms. During the past decade, we have witnessed an explosion of research identifying novel mechanisms by which mitochondria control various cellular functions and cells maintain the homeostasis of mitochondria and metabolism in various cell types. Mitochondria are particularly abundant in the heart, and mitochondrial dysfunction and changes in cellular metabolism are commonly observed in failing or stressed hearts. However, there is a significant gap in our understanding of these mechanisms in cardiomyocytes and those in other cell types. The overall learning objectives of this meeting are to: 1) Understand how the novel functions of mitochondria contribute to the development or the prevention of myocardial injury and heart failure, and 2) Discuss how the quality of mitochondria is maintained in adult cardiomyocytes, whose mitochondrial dynamics are quite distinct from other commonly investigated cell types. Special emphasis will be placed on discussing the function and the mechanism of mitophagy; a novel mechanism of cell death mediated through autophagy; interaction between mitochondria dynamics and mitophagy; mitochondrial unfolded protein response (UPR) controlling aging, stress resistance and longevity; the role of metabolic intermediates as signaling mechanisms; and novel biomarkers identified through metabolomics analyses. With a joint session on angiogenesis shared with the meeting on “Angiogenesis and Vascular Disease,” attendees will get a quick overview regarding how mitochondria and metabolism regulate angiogenesis, a critical determinant for physiological versus pathological hypertrophy and ischemic injury. Overall, the audience will obtain better understanding regarding how the function of mitochondria is regulated in the heart, how it affects the overall function of the cardiovascular system, and how one intervenes with mitochondria and metabolism to achieve better treatment for heart failure and other cardiovascular diseases.
Scholarship Deadline: January 11 2017
Discounted Abstract Deadline: January 11 2017
Abstract Deadline: February 8 2017
Discounted Registration Deadline: March 8 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer HealthCare Pharmaceuticals
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
American Association for the Advancement of Science (AAAS)American Association for the Advancement of Science (AAAS)
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL137293-01
Funding for this conference was made possible (in part) by HL137293-01 from the National Heart, Lung and Blood Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the NIH; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, May 08 | 4:00PM - 8:00PM
Arrival and Registration
Room: Eldorado Lounge


Monday, May 08 | 6:00PM - 8:00PM
Welcome Mixer
Room: Eldorado Lounge
No registration fees are used to fund alcohol served at this function.

Tuesday, May 09 | 7:30AM - 8:30AM
Breakfast
Room: Anasazi Ballroom


Tuesday, May 09 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Eldorado Grand Ballroom

Speaker 1 of 5
* Junichi Sadoshima, Rutgers New Jersey Medical School, USA

Tuesday, May 09 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Eldorado Grand Ballroom

Speaker 2 of 5
* Luisa Iruela-Arispe, University of California, Los Angeles, USA

Tuesday, May 09 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Eldorado Grand Ballroom

Speaker 3 of 5
Kari K. Alitalo, University of Helsinki, Finland
Therapeutic Potential of Vascular Growth Factors

Tuesday, May 09 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Eldorado Grand Ballroom

Speaker 4 of 5
David C. Chan, California Institute of Technology, USA
Mitochondria Dynamics

Tuesday, May 09 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Eldorado Grand Ballroom


Coffee Break

Tuesday, May 09 | 10:20AM - 12:30PM
Metabolism and Disease (Joint)
Room: Eldorado Grand Ballroom

Speaker 1 of 5
Robert E. Gerszten, Beth Israel Deaconess Medical Center, USA
Metabolic Profiles and the Risk of Cardiometabolic Diseases

Tuesday, May 09 | 10:20AM - 12:30PM
Metabolism and Disease (Joint)
Room: Eldorado Grand Ballroom

Speaker 2 of 5
* Andrew G. Dillin, University of California, Berkeley, USA
Mitochondria Mitokines and Aging

Tuesday, May 09 | 10:20AM - 12:30PM
Metabolism and Disease (Joint)
Room: Eldorado Grand Ballroom

Speaker 3 of 5
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Angiogenesis Revisited: Role and (Therapeutic) Implications of Endothelial Metabolism

Tuesday, May 09 | 10:20AM - 12:30PM
Metabolism and Disease (Joint)
Room: Eldorado Grand Ballroom

Speaker 4 of 5
Arpita Chowdhury, Universitätsmedizin Göttingen, Germany
Short Talk: Oxidative Stress and Altered Mitochondrial Signaling in Barth Syndrome Models

Tuesday, May 09 | 10:20AM - 12:30PM
Metabolism and Disease (Joint)
Room: Eldorado Grand Ballroom

Speaker 5 of 5
Nicholas Sibinga, Albert Einstein College of Medicine, USA
Short Talk: Control of Mitochondrial Function by Atypical Cadherins

Tuesday, May 09 | 12:30PM - 5:00PM
On Own for Lunch


Tuesday, May 09 | 12:30PM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Tuesday, May 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Tuesday, May 09 | 2:30PM - 4:30PM
Workshop 1: How to Evaluate Metabolism in the Heart: From th
e Langendorff Perfusion to Metabolome Analyses
Room: Eldorado B

Speaker 1 of 7
* Toren Finkel, University of Pittsburgh, UPMC, USA

Tuesday, May 09 | 2:30PM - 4:30PM
Workshop 1: How to Evaluate Metabolism in the Heart: From th
e Langendorff Perfusion to Metabolome Analyses
Room: Eldorado B

Speaker 2 of 7
Larissa Pfisterer, Boehringer Ingelheim Pharma GmbH & Co KG, Germany
Regulation of Endothelial Cell Metabolism by Long Noncoding RNA lncflow2

Tuesday, May 09 | 2:30PM - 4:30PM
Workshop 1: How to Evaluate Metabolism in the Heart: From th
e Langendorff Perfusion to Metabolome Analyses
Room: Eldorado B

Speaker 3 of 7
Jessica M. Pfleger, Temple University, USA
Bioenergetics as a Tool for Assessing Cardiomyocyte Response to ß–Adrenergic Stimulation and Insulin Resistance

Tuesday, May 09 | 2:30PM - 4:30PM
Workshop 1: How to Evaluate Metabolism in the Heart: From th
e Langendorff Perfusion to Metabolome Analyses
Room: Eldorado B

Speaker 4 of 7
Paul T. Schumacker, Northwestern University, USA
Mitochondrial Complexes I and III Regulate Cardiomyocyte Proliferation in Adult Mouse Hearts

Tuesday, May 09 | 2:30PM - 4:30PM
Workshop 1: How to Evaluate Metabolism in the Heart: From th
e Langendorff Perfusion to Metabolome Analyses
Room: Eldorado B

Speaker 5 of 7
Junco Shibayama Warren, University of Utah, USA
The Histone Methyltransferase Smyd1 Regulates Mitochondrial Energetics in Cardiomyocytes

Tuesday, May 09 | 2:30PM - 4:30PM
Workshop 1: How to Evaluate Metabolism in the Heart: From th
e Langendorff Perfusion to Metabolome Analyses
Room: Eldorado B

Speaker 6 of 7
Yuan Zhang, University of Iowa, USA
Ketogenic Diet Rescues Cardiac Hypertrophy and Heart Failure Induced by Loss of the Mitochondrial Pyruvate Carrier 1

Tuesday, May 09 | 2:30PM - 4:30PM
Workshop 1: How to Evaluate Metabolism in the Heart: From th
e Langendorff Perfusion to Metabolome Analyses
Room: Eldorado B

Speaker 7 of 7
Dan Shao, University of Washington, USA
Glucose Promotes Cell Growth by Suppressing Branched-Chain Amino Acid Degradation

Tuesday, May 09 | 2:30PM - 4:30PM
Workshop 1: Current Strategies for Funding Angiogenesis and
Vascular Disease Research
This session is from Angiogenesis
Room: Eldorado A

Speaker 1 of 6
* Luisa Iruela-Arispe, University of California, Los Angeles, USA


Tuesday, May 09 | 2:30PM - 4:30PM
Workshop 1: Current Strategies for Funding Angiogenesis and
Vascular Disease Research
This session is from Angiogenesis
Room: Eldorado A

Speaker 2 of 6
Yunling Gao, NHLBI, National Institutes of Health, USA
Angiogenesis Research: The Extramural Portfolio Supported by the National Heart, Lung, and Blood Institute, 2008-2015


Tuesday, May 09 | 2:30PM - 4:30PM
Workshop 1: Current Strategies for Funding Angiogenesis and
Vascular Disease Research
This session is from Angiogenesis
Room: Eldorado A

Speaker 3 of 6
Morris J. Birnbaum, Pfizer Inc., USA


Tuesday, May 09 | 2:30PM - 4:30PM
Workshop 1: Current Strategies for Funding Angiogenesis and
Vascular Disease Research
This session is from Angiogenesis
Room: Eldorado A

Speaker 4 of 6
Philip Tagari, Amgen, Inc., USA
Amgen – Funding External Innovation


Tuesday, May 09 | 2:30PM - 4:30PM
Workshop 1: Current Strategies for Funding Angiogenesis and
Vascular Disease Research
This session is from Angiogenesis
Room: Eldorado A

Speaker 5 of 6
Courtney Griffin, Oklahoma Medical Research Foundation, USA
Updates on the American Heart Association Research Funding Portfolio


Tuesday, May 09 | 2:30PM - 4:30PM
Workshop 1: Current Strategies for Funding Angiogenesis and
Vascular Disease Research
This session is from Angiogenesis
Room: Eldorado A

Speaker 6 of 6
Christer Betsholtz, Uppsala University, Sweden


Tuesday, May 09 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Tuesday, May 09 | 5:00PM - 7:00PM
Mitochondria Quality Control
Room: Eldorado B

Speaker 1 of 4
Gerald W. Dorn, II, Washington University School of Medicine, USA
The Cardiomyopathy of Defective Mitochondrial Fusion

Tuesday, May 09 | 5:00PM - 7:00PM
Mitochondria Quality Control
Room: Eldorado B

Speaker 2 of 4
* Junichi Sadoshima, Rutgers New Jersey Medical School, USA
Mitophagy in the Heart

Tuesday, May 09 | 5:00PM - 7:00PM
Mitochondria Quality Control
Room: Eldorado B

Speaker 3 of 4
R. Luke Wiseman, The Scripps Research Institute, USA
Stress-Responsive Regulation of Mitochondria Inner Membrane Proteostasis

Tuesday, May 09 | 5:00PM - 7:00PM
Mitochondria Quality Control
Room: Eldorado B

Speaker 4 of 4
Ana Victoria Lechuga Vieco, Spanish National Center for Cardiovascular Research, Spain
Short Talk: Conflict between Mitochondrial DNA Variants

Tuesday, May 09 | 5:00PM - 7:00PM
Metabolite Signaling in Angiogenesis and Vascular Disease
This session is from Angiogenesis
Room: Eldorado A

Speaker 1 of 5
* William C. Sessa, Yale University School of Medicine, USA


Tuesday, May 09 | 5:00PM - 7:00PM
Metabolite Signaling in Angiogenesis and Vascular Disease
This session is from Angiogenesis
Room: Eldorado A

Speaker 2 of 5
Morris J. Birnbaum, Pfizer Inc., USA
Control of Hepatic Lipid Metabolism


Tuesday, May 09 | 5:00PM - 7:00PM
Metabolite Signaling in Angiogenesis and Vascular Disease
This session is from Angiogenesis
Room: Eldorado A

Speaker 3 of 5
Christer Betsholtz, Uppsala University, Sweden
Pericytes as Regulators of Vascular Stability


Tuesday, May 09 | 5:00PM - 7:00PM
Metabolite Signaling in Angiogenesis and Vascular Disease
This session is from Angiogenesis
Room: Eldorado A

Speaker 4 of 5
J. David Symons, University of Utah, USA
Short Talk: Endothelial Cell Autophagy Maintains Shear-Stress-Induced Nitric Oxide Generation via Glycolysis-Dependent Purinergic Signaling to eNOS


Tuesday, May 09 | 5:00PM - 7:00PM
Metabolite Signaling in Angiogenesis and Vascular Disease
This session is from Angiogenesis
Room: Eldorado A

Speaker 5 of 5
Andreas M. Beyer, Medical College of Wisconsin, USA
Short Talk: Autophagy is a Novel Regulatory Mechanism in the Human Microcirculation


Tuesday, May 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, May 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Anasazi Ballroom


Wednesday, May 10 | 7:30AM - 8:30AM
Breakfast
Room: Anasazi Ballroom


Wednesday, May 10 | 8:30AM - 11:45AM
Autophagy and Metabolism
Room: Eldorado B

Speaker 1 of 7
Heidi M. McBride, McGill University, Canada
Emerging Functions of Mitochondrial-Derived Vesicles in Health and Disease.

Wednesday, May 10 | 8:30AM - 11:45AM
Autophagy and Metabolism
Room: Eldorado B

Speaker 2 of 7
* Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Control of Metabolism by Chaperone-Mediated Autophagy

Wednesday, May 10 | 8:30AM - 11:45AM
Autophagy and Metabolism
Room: Eldorado B


Coffee Break

Wednesday, May 10 | 8:30AM - 11:45AM
Autophagy and Metabolism
Room: Eldorado B

Speaker 4 of 7
Daniel P. Kelly, University of Pennsylvania, USA
Mitochondrial Remodeling in the Developing and Diseased Heart

Wednesday, May 10 | 8:30AM - 11:45AM
Autophagy and Metabolism
Room: Eldorado B

Speaker 5 of 7
E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Myocardial Autophagy and Metabolic Regulation

Wednesday, May 10 | 8:30AM - 11:45AM
Autophagy and Metabolism
Room: Eldorado B

Speaker 6 of 7
Helena C. Kenny, University of Iowa, USA
Short Talk: Inducible Deletion of OPA1 Causes Heart Failure in Part by mTOR - Mediated Suppression of Autophagy

Wednesday, May 10 | 8:30AM - 11:45AM
Autophagy and Metabolism
Room: Eldorado B

Speaker 7 of 7
Iain Scott, University of Pittsburgh, USA
Short Talk: Acetylation of Mitochondrial Proteins by Gcn5l1 Promotes Enhanced Fatty Acid Oxidation in the Heart

Wednesday, May 10 | 8:30AM - 11:45AM
Transcriptional Control of Endothelial Fate
This session is from Angiogenesis
Room: Eldorado A

Speaker 1 of 8
* Courtney Griffin, Oklahoma Medical Research Foundation, USA


Wednesday, May 10 | 8:30AM - 11:45AM
Transcriptional Control of Endothelial Fate
This session is from Angiogenesis
Room: Eldorado A

Speaker 2 of 8
William T. Pu, Children's Hospital, Harvard Medical School, USA
Transcriptional and Epigenetic Regulation of Endothelial Gene Expression


Wednesday, May 10 | 8:30AM - 11:45AM
Transcriptional Control of Endothelial Fate
This session is from Angiogenesis
Room: Eldorado A

Speaker 3 of 8
Michael Potente, Max Planck Institute for Heart and Lung Research, Germany
EMBO Young Investigator Lecture: Metabolism, Metabolites and Endothelial Plasticity


Wednesday, May 10 | 8:30AM - 11:45AM
Transcriptional Control of Endothelial Fate
This session is from Angiogenesis
Room: Eldorado A


Coffee Break


Wednesday, May 10 | 8:30AM - 11:45AM
Transcriptional Control of Endothelial Fate
This session is from Angiogenesis
Room: Eldorado A

Speaker 5 of 8
Brian L. Black, University of California, San Francisco, USA
Identification of Injury- and Regeneration-Responsive Cardiac Endothelium Enhancer Elements


Wednesday, May 10 | 8:30AM - 11:45AM
Transcriptional Control of Endothelial Fate
This session is from Angiogenesis
Room: Eldorado A

Speaker 6 of 8
William C. Sessa, Yale University School of Medicine, USA
New Insights into Endothelial Lipid Metabolism


Wednesday, May 10 | 8:30AM - 11:45AM
Transcriptional Control of Endothelial Fate
This session is from Angiogenesis
Room: Eldorado A

Speaker 7 of 8
Manu Beerens, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: Prdm16 Modifies the Canonical Notch Output to Establish Proper Arterial Development


Wednesday, May 10 | 8:30AM - 11:45AM
Transcriptional Control of Endothelial Fate
This session is from Angiogenesis
Room: Eldorado A

Speaker 8 of 8
Akiko Mammoto, Medical College of Wisconsin, USA
Short Talk: YAP1 in Angiogenesis and Lung Regeneration


Wednesday, May 10 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, May 10 | 11:45AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Wednesday, May 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Wednesday, May 10 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Wednesday, May 10 | 5:00PM - 7:00PM
Cell Signaling and Metabolism
Room: Eldorado B

Speaker 1 of 4
Pinchas Cohen, University of Southern California, USA
Mitochondrial-Derived Peptides and their Role in Vascular Disease

Wednesday, May 10 | 5:00PM - 7:00PM
Cell Signaling and Metabolism
Room: Eldorado B

Speaker 2 of 4
Xiang-Dong Fu, University of California, San Diego, USA
A Novel Strategy to Inhibit Angiogenesis in Cancer

Wednesday, May 10 | 5:00PM - 7:00PM
Cell Signaling and Metabolism
Room: Eldorado B

Speaker 3 of 4
Arieh Moussaieff, Hebrew University of Jerusalem, Israel
The Metabolic Switch of Cells Exiting Pluripotency

Wednesday, May 10 | 5:00PM - 7:00PM
Cell Signaling and Metabolism
Room: Eldorado B

Speaker 4 of 4
* Lorrie A. Kirshenbaum, University of Manitoba, Canada
Short Talk: Alternative Spliced Form of Bnip3 Preferentially Interacts with Mitofusion2 and Endoplasmic Reticulum for Cell Survival

Wednesday, May 10 | 5:00PM - 7:00PM
Epigenetic Regulation of Vascular Growth
This session is from Angiogenesis
Room: Eldorado A

Speaker 1 of 5
* Brian L. Black, University of California, San Francisco, USA


Wednesday, May 10 | 5:00PM - 7:00PM
Epigenetic Regulation of Vascular Growth
This session is from Angiogenesis
Room: Eldorado A

Speaker 2 of 5
Stefanie Dimmeler, University of Frankfurt, Germany
Function of Long Noncoding RNAs in the Regulation of the Vasculature


Wednesday, May 10 | 5:00PM - 7:00PM
Epigenetic Regulation of Vascular Growth
This session is from Angiogenesis
Room: Eldorado A

Speaker 3 of 5
Philip Tagari, Amgen, Inc., USA
Pharmacological and Genetic Inhibition of Hypoxia-Inducible Factor Prolyl Hydroxylases


Wednesday, May 10 | 5:00PM - 7:00PM
Epigenetic Regulation of Vascular Growth
This session is from Angiogenesis
Room: Eldorado A

Speaker 4 of 5
Courtney Griffin, Oklahoma Medical Research Foundation, USA
Chromatin Remodeling and Vascular Development


Wednesday, May 10 | 5:00PM - 7:00PM
Epigenetic Regulation of Vascular Growth
This session is from Angiogenesis
Room: Eldorado A

Speaker 5 of 5
Federico Bussolino, University of Torino, Italy
Short Talk: Transcription Factor EB Regulates VEGFR2 Function


Wednesday, May 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, May 10 | 7:30PM - 10:00PM
Poster Session 2
Room: Anasazi Ballroom


Thursday, May 11 | 7:30AM - 8:30AM
Breakfast
Room: Anasazi Ballroom


Thursday, May 11 | 8:30AM - 11:45AM
Hypoxia Sensing Mechanism and Mitophagy (Joint)
Room: Eldorado Grand Ballroom

Speaker 1 of 8
* Stefanie Dimmeler, University of Frankfurt, Germany

Thursday, May 11 | 8:30AM - 11:45AM
Hypoxia Sensing Mechanism and Mitophagy (Joint)
Room: Eldorado Grand Ballroom

Speaker 2 of 8
Åsa B. Gustafsson, University of California, San Diego, USA
Parkin-Dependent Degradation of Mitochondria by a Rab5 Endosomal Pathway


Thursday, May 11 | 8:30AM - 11:45AM
Hypoxia Sensing Mechanism and Mitophagy (Joint)
Room: Eldorado Grand Ballroom

Speaker 3 of 8
* Kenneth Walsh, University of Virginia School of Medicine, USA
Clonal Hematopoiesis and Cardio-metabolic Disease: New Mechanisms, New Therapeutic Opportunities

Thursday, May 11 | 8:30AM - 11:45AM
Hypoxia Sensing Mechanism and Mitophagy (Joint)
Room: Eldorado Grand Ballroom


Coffee Break

Thursday, May 11 | 8:30AM - 11:45AM
Hypoxia Sensing Mechanism and Mitophagy (Joint)
Room: Eldorado Grand Ballroom

Speaker 5 of 8
Marlene Rabinovitch, Stanford University, USA
A BMP-Notch Axis Coordinates Mitochondrial Function, Chromatin Remodeling and Gene Regulation to Regenerate Endothelium in Response to Injury

Thursday, May 11 | 8:30AM - 11:45AM
Hypoxia Sensing Mechanism and Mitophagy (Joint)
Room: Eldorado Grand Ballroom

Speaker 6 of 8
M. Celeste Simon, University of Pennsylvania, USA
Balancing Cell Growth with Homeostasis in the Tumor Microenvironment

Thursday, May 11 | 8:30AM - 11:45AM
Hypoxia Sensing Mechanism and Mitophagy (Joint)
Room: Eldorado Grand Ballroom

Speaker 7 of 8
Ivan Menendez-Montes, Fundacion CNIC, Spain
Short Talk: Cardiac HIF/VHL Signaling Regulates Glycolytic and Oxidative Metabolic Programs and Is Essential for Myocardial Maturation during Heart Development

Thursday, May 11 | 8:30AM - 11:45AM
Hypoxia Sensing Mechanism and Mitophagy (Joint)
Room: Eldorado Grand Ballroom

Speaker 8 of 8
Erin Reineke, Houston Methodist Research Institute, USA
Short Talk: Coordination of Cellular Function by Steroid-Receptor Coactivator 2 in Stress-Induced Cardiac Angiogenesis

Thursday, May 11 | 11:45AM - 5:00PM
On Own for Lunch


Thursday, May 11 | 11:45AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Thursday, May 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Thursday, May 11 | 2:30PM - 4:30PM
Workshop 2: Intracellular Signaling and Vascular Function
This session is from Angiogenesis
Room: Eldorado A

Speaker 1 of 6
* George E. Davis, University of Missouri School of Medicine, USA


Thursday, May 11 | 2:30PM - 4:30PM
Workshop 2: Intracellular Signaling and Vascular Function
This session is from Angiogenesis
Room: Eldorado A

Speaker 2 of 6
Christopher D. Kontos, Duke University Medical Center, USA
Caskin2: A Novel Regulator of Endothelial Cell Quiescence


Thursday, May 11 | 2:30PM - 4:30PM
Workshop 2: Intracellular Signaling and Vascular Function
This session is from Angiogenesis
Room: Eldorado A

Speaker 3 of 6
Qing Robert Miao, Medical College of Wisconsin, USA
Ras Signaling Is Required for Preventing Cerebrovascular Malformation


Thursday, May 11 | 2:30PM - 4:30PM
Workshop 2: Intracellular Signaling and Vascular Function
This session is from Angiogenesis
Room: Eldorado A

Speaker 4 of 6
Sarah J. Parker, Cedars Sinai Medical Center, USA
Proteomics Reveals Context-Dependent Shifts in Mitochondrial Protein Expression and Novel Non-Canonical TGFß Signaling Activation in the Aorta of Marfan Syndrome Mice


Thursday, May 11 | 2:30PM - 4:30PM
Workshop 2: Intracellular Signaling and Vascular Function
This session is from Angiogenesis
Room: Eldorado A

Speaker 5 of 6
Vivek Venkataramani, University Medical Center Göttingen, Germany
CD31 Expression Determines Redox Status and Chemoresistance in Human Angiosarcomas


Thursday, May 11 | 2:30PM - 4:30PM
Workshop 2: Intracellular Signaling and Vascular Function
This session is from Angiogenesis
Room: Eldorado A

Speaker 6 of 6
Ruowen Ge, National University of Singapore, Singapore
Extracellular Antiangiogenic Proteins Target Mitochondria through a Novel Route of Protein Trafficking via Endocytosis and Direct Endosome-Mitochondrion Fusion


Thursday, May 11 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Thursday, May 11 | 5:00PM - 7:00PM
Metabolic Regulation of Cell Signaling
Room: Eldorado B

Speaker 1 of 4
* Guido Kroemer, Cordeliers Research Center, France
Metabolic Regulation of Autophagy

Thursday, May 11 | 5:00PM - 7:00PM
Metabolic Regulation of Cell Signaling
Room: Eldorado B

Speaker 2 of 4
Michael N. Sack, NHLBI, National Institutes of Health, USA
Nutrient Sensing, Mitochondria and the Inflammasome


Thursday, May 11 | 5:00PM - 7:00PM
Metabolic Regulation of Cell Signaling
Room: Eldorado B

Speaker 3 of 4
Stephen Y. Chan, University of Pittsburgh School of Medicine, USA
The Emerging Nexus between Matrix Stiffness and Cellular Metabolism in the Diseased Pulmonary Vasculature: New Targets for Treating Pulmonary Hypertension

Thursday, May 11 | 5:00PM - 7:00PM
Metabolic Regulation of Cell Signaling
Room: Eldorado B

Speaker 4 of 4
Jianhua Xiong, NHLBI, National Institutes of Health, USA
Short Talk: Fatty Acid Oxidation Regulates Endothelial Cell Fate

Thursday, May 11 | 5:00PM - 7:00PM
Vascular Stability and Cell-Cell Interactions
This session is from Angiogenesis
Room: Eldorado A

Speaker 1 of 5
* Ralf H. Adams, Max Planck Institute for Molecular Biomedicine, Germany


Thursday, May 11 | 5:00PM - 7:00PM
Vascular Stability and Cell-Cell Interactions
This session is from Angiogenesis
Room: Eldorado A

Speaker 2 of 5
Harry (Hal) C. Dietz, Johns Hopkins University School of Medicine, Blade Therapeutics, USA
TGFbeta in Inherited Vasculopathies: A Matter of Aneurysmic Proportions


Thursday, May 11 | 5:00PM - 7:00PM
Vascular Stability and Cell-Cell Interactions
This session is from Angiogenesis
Room: Eldorado A

Speaker 3 of 5
George E. Davis, University of Missouri School of Medicine, USA
Molecular Determinants Governing EC-Pericyte Tube Co-Assembly and Stability


Thursday, May 11 | 5:00PM - 7:00PM
Vascular Stability and Cell-Cell Interactions
This session is from Angiogenesis
Room: Eldorado A

Speaker 4 of 5
Luisa Iruela-Arispe, University of California, Los Angeles, USA
Vascular Stability and Cell-Cell Interactions during Endothelial Regeneration


Thursday, May 11 | 5:00PM - 7:00PM
Vascular Stability and Cell-Cell Interactions
This session is from Angiogenesis
Room: Eldorado A

Speaker 5 of 5
Arie Horowitz, USA
Short Talk: Dynamic Equilibrium of Endothelial Cell Junctions Is Required for Vascular Morphogenesis


Thursday, May 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, May 11 | 7:30PM - 10:00PM
Poster Session 3
Room: Anasazi Ballroom


Friday, May 12 | 7:30AM - 8:30AM
Breakfast
Room: Anasazi Ballroom


Friday, May 12 | 8:30AM - 11:45AM
Regulation of mPTP Opening
Room: Eldorado B

Speaker 1 of 7
Toren Finkel, University of Pittsburgh, UPMC, USA
Mouse Models of the Mitochondrial Calcium Uniporter Complex

Friday, May 12 | 8:30AM - 11:45AM
Regulation of mPTP Opening
Room: Eldorado B

Speaker 2 of 7
Elizabeth A. Jonas, Yale University, USA
The Mitochondrial Permeability Transition Pore: Molecular Structure and Function in Health and Disease

Friday, May 12 | 8:30AM - 11:45AM
Regulation of mPTP Opening
Room: Eldorado B


Coffee Break

Friday, May 12 | 8:30AM - 11:45AM
Regulation of mPTP Opening
Room: Eldorado B

Speaker 4 of 7
John W. Elrod, Lewis Katz School of Medicine at Temple University, USA
Mitochondrial Calcium Exchange in Heart Disease

Friday, May 12 | 8:30AM - 11:45AM
Regulation of mPTP Opening
Room: Eldorado B

Speaker 5 of 7
* Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
Mitochondrial Calcium Regulated by MCU Underlies Skeletal Muscle Adaptation

Friday, May 12 | 8:30AM - 11:45AM
Regulation of mPTP Opening
Room: Eldorado B

Speaker 6 of 7
Amit U. Joshi, Stanford University SOM, USA
Short Talk: Mitochondrial Dynamics in Neurodegeneration in Patient-Derived Cells and in Animal Models

Friday, May 12 | 8:30AM - 11:45AM
Regulation of mPTP Opening
Room: Eldorado B

Speaker 7 of 7
Vivian W. Moraes, The Scripps Research Institute, USA
Short Talk: PERK Activation Regulates Mitochondrial Quality Control during Endoplasmic Reticulum Stress

Friday, May 12 | 8:30AM - 11:45AM
Organ Specific Vasculature
This session is from Angiogenesis
Room: Eldorado A

Speaker 1 of 8
* Kathleen M. Caron, University of North Carolina at Chapel Hill, USA


Friday, May 12 | 8:30AM - 11:45AM
Organ Specific Vasculature
This session is from Angiogenesis
Room: Eldorado A

Speaker 2 of 8
Ralf H. Adams, Max Planck Institute for Molecular Biomedicine, Germany
Organ-Specific and Functional Specialization of Blood Vessels


Friday, May 12 | 8:30AM - 11:45AM
Organ Specific Vasculature
This session is from Angiogenesis
Room: Eldorado A

Speaker 3 of 8
Susan Quaggin, Northwestern University, USA
Unique Molecular and Functional Requirements of the Renal Vasculature


Friday, May 12 | 8:30AM - 11:45AM
Organ Specific Vasculature
This session is from Angiogenesis
Room: Eldorado A


Coffee Break


Friday, May 12 | 8:30AM - 11:45AM
Organ Specific Vasculature
This session is from Angiogenesis
Room: Eldorado A

Speaker 5 of 8
Anne C. Eichmann, Yale University School of Medicine, USA
Cross-Talk between Vessels and Nerves


Friday, May 12 | 8:30AM - 11:45AM
Organ Specific Vasculature
This session is from Angiogenesis
Room: Eldorado A

Speaker 6 of 8
Paul S. Frenette, Albert Einstein College of Medicine, USA
Bone Marrow Vascular Niche


Friday, May 12 | 8:30AM - 11:45AM
Organ Specific Vasculature
This session is from Angiogenesis
Room: Eldorado A

Speaker 7 of 8
Lisandra Vila Ellis, MD Anderson Cancer Center, USA
Short Talk: Investigating Alveolar Angiogenesis in the Developing Mouse Lung


Friday, May 12 | 8:30AM - 11:45AM
Organ Specific Vasculature
This session is from Angiogenesis
Room: Eldorado A

Speaker 8 of 8
Ching-Ling Ellen Lien, Saban Research Institute, Children's Hospital, USA
Short Talk: Coordinated Development of Coronary Vessels, Cortical Cardiomyocytes and Cardiac Lymphatics Supports Heart Morphogenesis and Regeneration


Friday, May 12 | 11:45AM - 5:00PM
On Own for Lunch


Friday, May 12 | 2:30PM - 4:30PM
Workshop 2: How to Evaluate Mitophagy and Mitochondrial Func
tion in the Cardiovascular System
Room: Eldorado B

Speaker 1 of 7
* Åsa B. Gustafsson, University of California, San Diego, USA

Friday, May 12 | 2:30PM - 4:30PM
Workshop 2: How to Evaluate Mitophagy and Mitochondrial Func
tion in the Cardiovascular System
Room: Eldorado B

Speaker 2 of 7
Brian Glancy, NHLBI and NIAMS, National Institutes of Health, USA
The Mitochondrial Reticulum of the Heart


Friday, May 12 | 2:30PM - 4:30PM
Workshop 2: How to Evaluate Mitophagy and Mitochondrial Func
tion in the Cardiovascular System
Room: Eldorado B

Speaker 3 of 7
Knut Lauritzen, Oslo University Hospital, Norway
Impaired Dynamics and Function of Mitochondria Caused by mtDNA Damage Leads to Heart Failure

Friday, May 12 | 2:30PM - 4:30PM
Workshop 2: How to Evaluate Mitophagy and Mitochondrial Func
tion in the Cardiovascular System
Room: Eldorado B

Speaker 4 of 7
Xiyuan Lu, University of California, Davis, USA
Mitochondrial Subpopulations and Heterogeneity in Adult Cardiac Myocytes Revealed by Confocal Imaging

Friday, May 12 | 2:30PM - 4:30PM
Workshop 2: How to Evaluate Mitophagy and Mitochondrial Func
tion in the Cardiovascular System
Room: Eldorado B

Speaker 5 of 7
Liming Pei, Children's Hospital of Philadelphia/University of Pennsylvania, USA
A Heart-Derived Hormone that Regulates Body Growth

Friday, May 12 | 2:30PM - 4:30PM
Workshop 2: How to Evaluate Mitophagy and Mitochondrial Func
tion in the Cardiovascular System
Room: Eldorado B

Speaker 6 of 7
Venkatesh Sundararajan, Rutgers New Jersey Medical School, USA
Mitochondrial Lon Protease Protects the Heart in vivo Against Ischemia-Reperfusion Injury by Reducing Oxidative Damage

Friday, May 12 | 2:30PM - 4:30PM
Workshop 2: How to Evaluate Mitophagy and Mitochondrial Func
tion in the Cardiovascular System
Room: Eldorado B

Speaker 7 of 7
Nuo Sun, NHLBI, National Institutes of Health, USA
Measuring Cardiac Mitophagy and the Role of USP30 in Heart Failure

Friday, May 12 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Friday, May 12 | 5:00PM - 7:00PM
Metabolism and Heart Failure
Room: Eldorado B

Speaker 1 of 4
* Richard N. Kitsis, Albert Einstein College of Medicine, USA
Chaperone-Mediated Autophagy in the Regulation of Mitochondrial Function and Heart Failure

Friday, May 12 | 5:00PM - 7:00PM
Metabolism and Heart Failure
Room: Eldorado B

Speaker 2 of 4
Rong Tian, University of Washington, USA
The Signaling Role of Branched Chain Amino Acids

Friday, May 12 | 5:00PM - 7:00PM
Metabolism and Heart Failure
Room: Eldorado B

Speaker 3 of 4
Stephen L. Archer, Queen's University, Canada
Role of Acquired Abnormalities in Mitochondrial Dynamics and the Mitochondrial Calcium Uniporter (MCU) in Pulmonary Hypertension

Friday, May 12 | 5:00PM - 7:00PM
Metabolism and Heart Failure
Room: Eldorado B

Speaker 4 of 4
Katsuhito Fujiu, University of Tokyo, Japan
Short Talk: Cardiac Macrophage Is Required to Avoid Heart Failure and Cardiac Sudden Death after Pressure Overload

Friday, May 12 | 5:00PM - 6:45PM
Lymphangiogenesis
This session is from Angiogenesis
Room: Eldorado A

Speaker 1 of 4
* Anne C. Eichmann, Yale University School of Medicine, USA


Friday, May 12 | 5:00PM - 6:45PM
Lymphangiogenesis
This session is from Angiogenesis
Room: Eldorado A

Speaker 2 of 4
Tsutomu Kume, Northwestern University, USA
Regulation of Postnatal Lymphatic Vessel Development by Foxc1 and Foxc2


Friday, May 12 | 5:00PM - 6:45PM
Lymphangiogenesis
This session is from Angiogenesis
Room: Eldorado A

Speaker 3 of 4
Tatiana V. Petrova, CHUV, University of Lausanne, Switzerland
Mechanisms of Lymphatic Vessel Specialization


Friday, May 12 | 5:00PM - 6:45PM
Lymphangiogenesis
This session is from Angiogenesis
Room: Eldorado A

Speaker 4 of 4
Kathleen M. Caron, University of North Carolina at Chapel Hill, USA
Lymphatics in Myocardial Injury and Repair


Friday, May 12 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Angiogenesis
Room: Eldorado A


Friday, May 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Friday, May 12 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Eldorado B


Friday, May 12 | 8:00PM - 11:00PM
Entertainment
Room: Anasazi Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Friday, May 12 | 8:00PM - 11:00PM
Cash Bar
Room: Anasazi Ballroom


Saturday, May 13 | 10:25AM - 10:25AM
Departure


*Session Chair.