Web Desc
T Cell Dysfunction, Cancer and Infection
Organizer(s): Daniel C. Douek, W. Nicholas Haining and Jedd D. Wolchok
Date: January 16 - 20, 2018
Location: Beaver Run Resort, Breckenridge, CO, USA
Sponsored by Amgen Inc., Incyte Corporation, Juno Therapeutics, Merck & Co., Inc., Regeneron Pharmaceuticals, Inc., Surface Oncology and TESARO, Inc.
Summary of Meeting:
T cell exhaustion is an acquired state of T cell dysfunction, associated with reduced T cell function, sustained expression of inhibitory receptors and a transcriptional state that is distinct from memory and effector T cells. T cell exhaustion is now recognized as a defining feature not only of chronic infections such as HIV, malaria and tuberculosis, but also of cancer. As a result, the search for effective approaches to reverse T cell exhaustion is the focus of immense therapeutic development. However, the similarities and differences between T cell dysfunction arising in chronic infection and tumors are not fully understood. Moreover, opportunities to identify new therapeutic approaches to reverse dysfunction based on parallels between the two disease states remain to be explored. This meeting will focus on the comparative biology and clinical therapeutics of T cell dysfunction in chronic viral infection and cancer. Drawing on leaders in fundamental T cell biology, computational science and clinical investigation, it will focus on common features and distinctive aspects of T cell dysfunction in cancer and chronic infection. The meeting will have broad relevance for T cell biology, tumor immunity, infectious disease and therapeutic development.
Scholarship Deadline: September 21 2017
Discounted Abstract Deadline: September 21 2017
Abstract Deadline: October 19 2017
Discounted Registration Deadline: November 20 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Amgen Inc.
Incyte CorporationJuno TherapeuticsMerck & Co., Inc.Regeneron Pharmaceuticals, Inc.Surface OncologyTESARO, Inc.
We gratefully acknowledge additional support for this conference from:
Oncotarget
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA224785-01
Funding for this conference was made possible (in part) by 1 R13 CA224785-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 16 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Tuesday, January 16 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Wednesday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Breckenridge Ballroom


Wednesday, January 17 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Colorado Ballroom

Speaker 1 of 3
* Daniel C. Douek, NIAID, National Institutes of Health, USA

Wednesday, January 17 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Colorado Ballroom

Speaker 2 of 3
* W. Nicholas Haining, Merck Research Laboratories, USA

Wednesday, January 17 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Colorado Ballroom

Speaker 3 of 3
Rafi Ahmed, Emory University School of Medicine, USA
A New Look at T Cell Exhaustion

Wednesday, January 17 | 9:00AM - 11:30AM
Adoptive T Cell Therapy for Cancer
Room: Colorado Ballroom

Speaker 1 of 7
* Susan M. Kaech, The Salk Institute, USA

Wednesday, January 17 | 9:00AM - 11:30AM
Adoptive T Cell Therapy for Cancer
Room: Colorado Ballroom

Speaker 2 of 7
Crystal L. Mackall, Stanford University, USA
Use of Adoptive T Cell Transfer in Pediatric Patients

Wednesday, January 17 | 9:00AM - 11:30AM
Adoptive T Cell Therapy for Cancer
Room: Colorado Ballroom


Coffee Break

Wednesday, January 17 | 9:00AM - 11:30AM
Adoptive T Cell Therapy for Cancer
Room: Colorado Ballroom

Speaker 4 of 7
Cassian Yee, University of Texas MD Anderson Cancer Center, USA
Endogenous T Cell Therapy: Finding Dory


Wednesday, January 17 | 9:00AM - 11:30AM
Adoptive T Cell Therapy for Cancer
Room: Colorado Ballroom

Speaker 5 of 7
Michael C. Jensen, Seattle Children's Research Institute, USA
Overcoming Barriers to Achieving Curative Outcomes Following CD19CAR T Cell Therapy For Recurrent/Refractory Pediatric ALL

Wednesday, January 17 | 9:00AM - 11:30AM
Adoptive T Cell Therapy for Cancer
Room: Colorado Ballroom

Speaker 6 of 7
Cyrille J. Cohen, Bar-Ilan University, Israel
Short Talk: Improved Targeting of Multiple Tumors and Viral-Infected Cells using T-Cells Engineered to Express NCR-Based Chimeric Receptors

Wednesday, January 17 | 9:00AM - 11:30AM
Adoptive T Cell Therapy for Cancer
Room: Colorado Ballroom

Speaker 7 of 7
Lexus Johnson, University of Pennsylvania, USA
Short Talk: Intratumoral Immune Activation Informs Rational CAR T Cell Design

Wednesday, January 17 | 11:30AM - 5:00PM
On Own for Lunch


Wednesday, January 17 | 11:30AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Wednesday, January 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Wednesday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, January 17 | 5:00PM - 7:00PM
T Cells and their Microenvironment
Room: Colorado Ballroom

Speaker 1 of 5
* W. Nicholas Haining, Merck Research Laboratories, USA

Wednesday, January 17 | 5:00PM - 7:00PM
T Cells and their Microenvironment
Room: Colorado Ballroom

Speaker 2 of 5
Daniel C. Douek, NIAID, National Institutes of Health, USA
Influence of the Systemic Microbiome on Inflammation During HIV Infection

Wednesday, January 17 | 5:00PM - 7:00PM
T Cells and their Microenvironment
Room: Colorado Ballroom

Speaker 3 of 5
David G. Brooks, Princess Margaret Cancer Center, Canada
Type I Interferons and Inflammation in T Cell Immunity

Wednesday, January 17 | 5:00PM - 7:00PM
T Cells and their Microenvironment
Room: Colorado Ballroom

Speaker 4 of 5
Susan M. Kaech, The Salk Institute, USA
Anti-Tumor T Cells: You Are What You Eat

Wednesday, January 17 | 5:00PM - 7:00PM
T Cells and their Microenvironment
Room: Colorado Ballroom

Speaker 5 of 5
Rafick Sekaly, Emory University, USA
Short Talk: PD-1 and IL-1 Control Two Independent Mechanisms of Immune Dysfunction and Response to Treatment in Cancer and HIV

Wednesday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, January 17 | 7:30PM - 10:00PM
Poster Session 1
Room: Breckenridge Ballroom


Thursday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Breckenridge Ballroom


Thursday, January 18 | 8:00AM - 11:15AM
Basic Biology of T Cell Exhaustion
Room: Colorado Ballroom

Speaker 1 of 8
* E. John Wherry, University of Pennsylvania, USA

Thursday, January 18 | 8:00AM - 11:15AM
Basic Biology of T Cell Exhaustion
Room: Colorado Ballroom

Speaker 2 of 8
W. Nicholas Haining, Merck Research Laboratories, USA
The Epigenetic Landscape of T Cell Exhaustion

Thursday, January 18 | 8:00AM - 11:15AM
Basic Biology of T Cell Exhaustion
Room: Colorado Ballroom

Speaker 3 of 8
Ananda W. Goldrath, University of California, San Diego, USA
Transcriptional Regulation of CD8 T Cell Immunity

Thursday, January 18 | 8:00AM - 11:15AM
Basic Biology of T Cell Exhaustion
Room: Colorado Ballroom


Coffee Break

Thursday, January 18 | 8:00AM - 11:15AM
Basic Biology of T Cell Exhaustion
Room: Colorado Ballroom

Speaker 5 of 8
Andrea Schietinger, Memorial Sloan Kettering Cancer Center, USA
Tumor-Specific T Cell Dysfunction

Thursday, January 18 | 8:00AM - 11:15AM
Basic Biology of T Cell Exhaustion
Room: Colorado Ballroom

Speaker 6 of 8
Dietmar Zehn, Technical University of Munich, Germany
Subsets and T Cell Differentiation in Chronic LCMV Infection

Thursday, January 18 | 8:00AM - 11:15AM
Basic Biology of T Cell Exhaustion
Room: Colorado Ballroom

Speaker 7 of 8
Curtis H. Cai, University of New South Wales, Australia
Short Talk: Elucidating the Factors Associated with Dysfunctional T-cell Responses in HCV Infection using scRNA-seq and Functional Analyses

Thursday, January 18 | 8:00AM - 11:15AM
Basic Biology of T Cell Exhaustion
Room: Colorado Ballroom

Speaker 8 of 8
Jennifer M. Dan, University of California, San Diego, USA
Short Talk: Recurrent Group A Streptococcus Tonsillitis Is a Genetic Immunosusceptibility Disease with Aberrant Follicular
Helper CD4+ T Cells


Thursday, January 18 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, January 18 | 11:15AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Thursday, January 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Thursday, January 18 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, January 18 | 5:00PM - 7:00PM
Adoptive T Cell Transfer for Infection
Room: Colorado Ballroom

Speaker 1 of 5
* Robert Thimme, University Medical Center Freiburg, Germany

Thursday, January 18 | 5:00PM - 7:00PM
Adoptive T Cell Transfer for Infection
Room: Colorado Ballroom

Speaker 2 of 5
Philip D. Greenberg, University of Washington, USA
Novel Approaches to Isolating Receptors and Engineering Cells to Target Tumor Antigens

Thursday, January 18 | 5:00PM - 7:00PM
Adoptive T Cell Transfer for Infection
Room: Colorado Ballroom

Speaker 3 of 5
James L. Riley, University of Pennsylvania, USA
Engineering T Cells to Functionally Cure HIV-1 Infection

Thursday, January 18 | 5:00PM - 7:00PM
Adoptive T Cell Transfer for Infection
Room: Colorado Ballroom

Speaker 4 of 5
Catherine M. Bollard, Children’s National Health System, USA
Virus-Specific T Cells Post HSCT- Broadening Applicability

Thursday, January 18 | 5:00PM - 7:00PM
Adoptive T Cell Transfer for Infection
Room: Colorado Ballroom

Speaker 5 of 5
Sanjivan Sanjivan Gautam, NCI, National Institutes of Health, USA
Short Talk: The Transcription Factor Myb Enhances CD8+ T Cell Memory and Anti-Tumor Function by Inducing Tcf7 and Restraining Zeb2 Transcription

Thursday, January 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, January 18 | 7:30PM - 10:00PM
Poster Session 2
Room: Breckenridge Ballroom


Friday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Breckenridge Ballroom


Friday, January 19 | 8:00AM - 11:15AM
Basic Biology of Inhibitory Receptors
Room: Colorado Ballroom

Speaker 1 of 8
* Rafick Sekaly, Emory University, USA

Friday, January 19 | 8:00AM - 11:15AM
Basic Biology of Inhibitory Receptors
Room: Colorado Ballroom

Speaker 2 of 8
Arlene H. Sharpe, Harvard Medical School, USA
The Role of the PD-1 Pathway in Regulating Immunity

Friday, January 19 | 8:00AM - 11:15AM
Basic Biology of Inhibitory Receptors
Room: Colorado Ballroom

Speaker 3 of 8
Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
LAG3: Function, Mode of Action and its Impact on Cancer Immunotherapy

Friday, January 19 | 8:00AM - 11:15AM
Basic Biology of Inhibitory Receptors
Room: Colorado Ballroom


Coffee Break

Friday, January 19 | 8:00AM - 11:15AM
Basic Biology of Inhibitory Receptors
Room: Colorado Ballroom

Speaker 5 of 8
Sadna Budhu, Memorial Sloan Kettering Cancer Center, USA
Blockade of Surface-Bound TGF-ß on Regulatory T Cells Abrogates Suppression of Effector T Cell Function in the Tumor Microenvironment

Friday, January 19 | 8:00AM - 11:15AM
Basic Biology of Inhibitory Receptors
Room: Colorado Ballroom

Speaker 6 of 8
Ira Mellman, Genentech, Inc., USA
PD-L1 Blockade and Targeted Therapy

Friday, January 19 | 8:00AM - 11:15AM
Basic Biology of Inhibitory Receptors
Room: Colorado Ballroom

Speaker 7 of 8
Frédéric Duval, University of Montreal, Canada
Short Talk: Notch Signaling Dampens Cd8 T Cell Exhaustion During Chronic Infection

Friday, January 19 | 8:00AM - 11:15AM
Basic Biology of Inhibitory Receptors
Room: Colorado Ballroom

Speaker 8 of 8
Hazem E. Ghoneim, St Jude Children's Research Hospital, USA
Short Talk: Inhibiting Exhaustion-Associated Epigenetic Programs Enhances PD-1 Blockade-Mediated T Cell Rejuvenation

Friday, January 19 | 11:15AM - 5:00PM
On Own for Lunch


Friday, January 19 | 11:15AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Friday, January 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Friday, January 19 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, January 19 | 5:00PM - 7:00PM
Checkpoint Blockade
Room: Colorado Ballroom

Speaker 1 of 5
* Daniel C. Douek, NIAID, National Institutes of Health, USA

Friday, January 19 | 5:00PM - 7:00PM
Checkpoint Blockade
Room: Colorado Ballroom

Speaker 2 of 5
Roberta Zappasodi, Memorial Sloan-Kettering Cancer Center, USA
Non-conventional Immunosuppressive TFH-like CD4+ T Cells Promote Resistance to Immune Checkpoint Blockade Therapy

Friday, January 19 | 5:00PM - 7:00PM
Checkpoint Blockade
Room: Colorado Ballroom

Speaker 3 of 5
Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA
PD-1 Blockade in Virus-Associated Cancers: Intersection of Antitumor Immunity and Infectious Immunity

Friday, January 19 | 5:00PM - 7:00PM
Checkpoint Blockade
Room: Colorado Ballroom

Speaker 4 of 5
E. John Wherry, University of Pennsylvania, USA
T Cell Exhaustion and Immunotherapy

Friday, January 19 | 5:00PM - 7:00PM
Checkpoint Blockade
Room: Colorado Ballroom

Speaker 5 of 5
Rebecca Dookie, University of Manchester, UK
Short Talk: Investigating the Role of Checkpoint Inhibitors in Malaria-Induced T Cell Exhaustion

Friday, January 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Friday, January 19 | 7:30PM - 10:00PM
Poster Session 3
Room: Breckenridge Ballroom


Saturday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Breckenridge Ballroom


Saturday, January 20 | 8:00AM - 11:00AM
Targets for T Cells
Room: Colorado Ballroom

Speaker 1 of 7
* Robert A. Seder, NIAID, National Institutes of Health, USA

Saturday, January 20 | 8:00AM - 11:00AM
Targets for T Cells
Room: Colorado Ballroom

Speaker 2 of 7
Robert Thimme, University Medical Center Freiburg, Germany
Impact of Antigen Recognition on T Cell Diversification in Chronic Viral Hepatitis

Saturday, January 20 | 8:00AM - 11:00AM
Targets for T Cells
Room: Colorado Ballroom

Speaker 3 of 7
Pramod K. Srivastava, University of Connecticut School of Medicine, USA
Broadening the View of Mutational Antigens for Cancer Immunotherapy

Saturday, January 20 | 8:00AM - 11:00AM
Targets for T Cells
Room: Colorado Ballroom


Coffee Break

Saturday, January 20 | 8:00AM - 11:00AM
Targets for T Cells
Room: Colorado Ballroom

Speaker 5 of 7
Lélia Delamarre, Genentech, Inc., USA
Determinants of Cancer Neoantigen Immunogenicity

Saturday, January 20 | 8:00AM - 11:00AM
Targets for T Cells
Room: Colorado Ballroom

Speaker 6 of 7
Brendan Bulik-Sullivan, Gritstone Oncology, USA
Short Talk: Antigen Identification for Cancer Immunotherapy by Deep Learning on Tumor HLA Peptides

Saturday, January 20 | 8:00AM - 11:00AM
Targets for T Cells
Room: Colorado Ballroom

Speaker 7 of 7
Thomas Duhen, Agonox, USA
Short Talk: Co-Expression of CD39 and CD103 Identifies Tumor-Reactive CD8 TIL in Human Solid Tumors

Saturday, January 20 | 11:00AM - 5:00PM
On Own for Lunch


Saturday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, January 20 | 5:00PM - 6:15PM
Vaccines to Revive T Cell Responses
Room: Colorado Ballroom

Speaker 1 of 3
* Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA

Saturday, January 20 | 5:00PM - 6:15PM
Vaccines to Revive T Cell Responses
Room: Colorado Ballroom

Speaker 2 of 3
Robert A. Seder, NIAID, National Institutes of Health, USA
Adjuvants for T Cell Vaccines

Saturday, January 20 | 5:00PM - 6:15PM
Vaccines to Revive T Cell Responses
Room: Colorado Ballroom

Speaker 3 of 3
Darrell J. Irvine, Massachusetts Institute of Technology, USA
Boosting T Cells by Getting Vaccines Where They Need to Go

Saturday, January 20 | 6:15PM - 7:00PM
Closing Keynote Address
Room: Colorado Ballroom

Speaker 1 of 2
* Daniel C. Douek, NIAID, National Institutes of Health, USA

Saturday, January 20 | 6:15PM - 7:00PM
Closing Keynote Address
Room: Colorado Ballroom

Speaker 2 of 2
Carl H. June, University of Pennsylvania, USA
Enhancing Engineered T Cell Therapy for Cancer

Saturday, January 20 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Colorado Ballroom


Saturday, January 20 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Saturday, January 20 | 8:00PM - 11:00PM
Entertainment
Room: Breckenridge Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Saturday, January 20 | 8:00PM - 11:00PM
Cash Bar
Room: Breckenridge Ballroom


Sunday, January 21 | 10:24AM - 10:24AM
Departure


*Session Chair.