Web Desc
Cell Death, Inflammation and Adaptation to Tissue Stress
Organizer(s): Pascal Meier, Eric H. Baehrecke and Kim Newton
Date: January 21 - 25, 2018
Location: Beaver Run Resort, Breckenridge, CO, USA
Sponsored by Akebia Therapeutics, Amgen Inc., Boehringer Ingelheim Pharmaceuticals, Inc., Cancer Research UK, Genentech, Inc. and Roche
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Summary of Meeting:
Cell death and inflammation are ancient processes of fundamental biological importance in both normal physiology and human disease pathologies. The recent observation that cell death regulatory components have dual roles in cell death and inflammation suggests that these proteins function not primarily to kill, but to coordinate tissue repair and adaptation to tissue stress. This perspective unifies cell death components as positive regulators of tissue repair that replace malfunctioning or damaged tissues and enhances the resilience of epithelia to insult. It is now recognized that cells that die do not do so silently, but release a variety of paracrine signals to communicate with their cellular environment to ensure tissue regeneration and wound healing. Moreover, inflammatory signaling pathways, such as those emanating from the TNF-receptor or Toll-related receptors, take part in cell competition to eliminate developmentally aberrant clones. Understanding how dead and dying cells initiate and escalate inflammation has important implications for the development of novel treatment strategies for diseases associated with aging, such as chronic inflammation and cancer. This conference explores the complex relationship between cell death and inflammation, and how this cross-talk impacts on adaptation to tissue stress, inflammatory diseases, tumor formation and drug resistance. Overall, the goals of the conference are to: 1) Explore the gaps in our current understanding of how dead and dying cells influence inflammatory responses in tissue repair and disease settings; 2) Foster communication and collaborations between scientists focusing on different areas of biology (cell death, innate immunity, adaptive immunity, cancer and model organisms); 3) Pinpoint nodes of intersection linking all research fields; 4) Define key-regulatory paradigms at these intersections, and discuss molecular mechanisms that control these processes; 5) Share information on possible consequences of deregulation; 6) Discuss translational aspects and potential drug targets, e.g. in pre-clinical models of malignant disease.
Scholarship Deadline: September 27 2017
Discounted Abstract Deadline: September 27 2017
Abstract Deadline: October 25 2017
Discounted Registration Deadline: November 28 2017
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Akebia Therapeutics
Amgen Inc.
Boehringer Ingelheim Pharmaceuticals, Inc.Cancer Research UKGenentech, Inc.Roche
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI136036-01
Funding for this conference was made possible (in part) by 1 R13 AI136036-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 21 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Sunday, January 21 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Monday, January 22 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Peaks 4 & 5

Speaker 1 of 2
* Pascal Meier, Institute of Cancer Research, UK

Monday, January 22 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Peaks 4 & 5

Speaker 2 of 2
Douglas R. Green, St. Jude Children's Research Hospital, USA
Programmed Necrosis in Inflammation: Toward Identification of the Effector Molecules

Monday, January 22 | 9:00AM - 11:30AM
RIP Kinases and the Regulation of Tissue Homeostasis
Room: Peaks 4 & 5

Speaker 1 of 7
* Kevin M. Ryan, Beatson Institute for Cancer Research, UK

Monday, January 22 | 9:00AM - 11:30AM
RIP Kinases and the Regulation of Tissue Homeostasis
Room: Peaks 4 & 5

Speaker 2 of 7
Manolis Pasparakis, University of Cologne, Germany
Epithelial Cell Death in Tissue Homeostasis and Inflammation

Monday, January 22 | 9:00AM - 11:30AM
RIP Kinases and the Regulation of Tissue Homeostasis
Room: Peaks 4 & 5


Coffee Break

Monday, January 22 | 9:00AM - 11:30AM
RIP Kinases and the Regulation of Tissue Homeostasis
Room: Peaks 4 & 5

Speaker 4 of 7
John Silke, Walter and Eliza Hall Institute of Medical Research, Australia
Primed to Die - The in vivo Consequences of Activating Mutations in the Necroptotic Cell Death Pathway

Monday, January 22 | 9:00AM - 11:30AM
RIP Kinases and the Regulation of Tissue Homeostasis
Room: Peaks 4 & 5

Speaker 5 of 7
Igor E. Brodsky, University of Pennsylvania, USA
Short Talk: RIPK1-Dependent Apoptosis Mediates Effector-Triggered Immunity in Response to Pathogen Blockade of Innate Immune Signaling

Monday, January 22 | 9:00AM - 11:30AM
RIP Kinases and the Regulation of Tissue Homeostasis
Room: Peaks 4 & 5

Speaker 6 of 7
Alessandro Barbarulo, University College London, UK
Short Talk: RIPK1 Regulates Mature Thymocyte Death and Survival in vivo in Response to TNF Independently of NF-?B

Monday, January 22 | 9:00AM - 11:30AM
RIP Kinases and the Regulation of Tissue Homeostasis
Room: Peaks 4 & 5

Speaker 7 of 7
Vishva M. Dixit, Genentech, Inc., USA
Inflammasomes and their Roles in Health and Disease

Monday, January 22 | 11:30AM - 5:00PM
On Own for Lunch


Monday, January 22 | 11:30AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Monday, January 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Monday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, January 22 | 5:00PM - 7:00PM
Autophagy, Cell Health and Death
Room: Peaks 4 & 5

Speaker 1 of 5
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Monday, January 22 | 5:00PM - 7:00PM
Autophagy, Cell Health and Death
Room: Peaks 4 & 5

Speaker 2 of 5
Eric H. Baehrecke, University of Massachusetts Medical School, USA
Autophagy and Cell Death

Monday, January 22 | 5:00PM - 7:00PM
Autophagy, Cell Health and Death
Room: Peaks 4 & 5

Speaker 3 of 5
Kevin M. Ryan, Beatson Institute for Cancer Research, UK
The Role of Autophagy in Cellular Stress Responses and Tumor Development

Monday, January 22 | 5:00PM - 7:00PM
Autophagy, Cell Health and Death
Room: Peaks 4 & 5

Speaker 4 of 5
Kim McCall, Boston University, USA
Short Talk: Lysosomal Machinery Promotes Extracellular Acidification to Direct Non-Apoptotic Programmed Cell Death

Monday, January 22 | 5:00PM - 7:00PM
Autophagy, Cell Health and Death
Room: Peaks 4 & 5

Speaker 5 of 5
Ivan Dikic, Goethe University Medical School, Germany
Catalysis and Inhibition of Phosphoribosyl-Dependent Ubiquitination

Monday, January 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3
No registration fees are used to fund alcohol served at this function.

Monday, January 22 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 1-3


Tuesday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Tuesday, January 23 | 8:00AM - 11:15AM
Inflammatory Cell Death
Room: Peaks 4 & 5

Speaker 1 of 9
* John Silke, Walter and Eliza Hall Institute of Medical Research, Australia

Tuesday, January 23 | 8:00AM - 11:15AM
Inflammatory Cell Death
Room: Peaks 4 & 5

Speaker 2 of 9
* Manolis Pasparakis, University of Cologne, Germany

Tuesday, January 23 | 8:00AM - 11:15AM
Inflammatory Cell Death
Room: Peaks 4 & 5

Speaker 3 of 9
Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Cell Death by Inflammasomes

Tuesday, January 23 | 8:00AM - 11:15AM
Inflammatory Cell Death
Room: Peaks 4 & 5

Speaker 4 of 9
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Regulation of Inflammatory Responses

Tuesday, January 23 | 8:00AM - 11:15AM
Inflammatory Cell Death
Room: Peaks 4 & 5


Coffee Break

Tuesday, January 23 | 8:00AM - 11:15AM
Inflammatory Cell Death
Room: Peaks 4 & 5

Speaker 6 of 9
Feng Shao, National Institute of Biological Sciences, China
Pyroptosis: From Innate Immunity to Cancer

Tuesday, January 23 | 8:00AM - 11:15AM
Inflammatory Cell Death
Room: Peaks 4 & 5

Speaker 7 of 9
Swarna Lekha Vijayaraj, University of Melbourne, Australia
Short Talk: Post-Translational Regulation of Interleukin-1ß

Tuesday, January 23 | 8:00AM - 11:15AM
Inflammatory Cell Death
Room: Peaks 4 & 5

Speaker 8 of 9
Moritz Gaidt, Ludwig Maximilians University, Germany
Short Talk: The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Tuesday, January 23 | 8:00AM - 11:15AM
Inflammatory Cell Death
Room: Peaks 4 & 5

Speaker 9 of 9
Kim Newton, Genentech, Inc., USA
Exploring the Pro-Survival Functions of Caspase-8 and RIPK1

Tuesday, January 23 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, January 23 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Tuesday, January 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Tuesday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, January 23 | 5:00PM - 7:00PM
Cancer as a Systemic Disease
Room: Peaks 4 & 5

Speaker 1 of 5
* Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia

Tuesday, January 23 | 5:00PM - 7:00PM
Cancer as a Systemic Disease
Room: Peaks 4 & 5

Speaker 2 of 5
Laura D. Attardi, Stanford University School of Medicine, USA
Deciphering p53 Transcriptional Networks in Tumor Suppression

Tuesday, January 23 | 5:00PM - 7:00PM
Cancer as a Systemic Disease
Room: Peaks 4 & 5

Speaker 3 of 5
Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Constructing and Deconstructing Cancer Using Mouse Models

Tuesday, January 23 | 5:00PM - 7:00PM
Cancer as a Systemic Disease
Room: Peaks 4 & 5

Speaker 4 of 5
Mads Daugaard, University of British Columbia, Canada
Short Talk: Targeting Cancer Using Malaria Host Cell-Anchor Proteins

Tuesday, January 23 | 5:00PM - 7:00PM
Cancer as a Systemic Disease
Room: Peaks 4 & 5

Speaker 5 of 5
Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA
Somatic p53 Mutations Drive Development of Triple-Negative Breast Cancer with Evolutionarily Distinct Metastases

Tuesday, January 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3
No registration fees are used to fund alcohol served at this function.

Tuesday, January 23 | 7:30PM - 10:00PM
Poster Session 2
Room: Peaks 1-3


Wednesday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Wednesday, January 24 | 8:00AM - 11:15AM
Adaptive Responses to Tissue Stress
Room: Peaks 4 & 5

Speaker 1 of 7
* John Silke, Walter and Eliza Hall Institute of Medical Research, Australia

Wednesday, January 24 | 8:00AM - 11:15AM
Adaptive Responses to Tissue Stress
Room: Peaks 4 & 5

Speaker 2 of 7
Pascal Meier, Institute of Cancer Research, UK
RIPK1 and the Maintenance of Tissue Homeostasis

Wednesday, January 24 | 8:00AM - 11:15AM
Adaptive Responses to Tissue Stress
Room: Peaks 4 & 5

Speaker 3 of 7
Andrew Oberst, University of Washington, USA
The RIP Kinases as Modulators of Inflammation and Immunity

Wednesday, January 24 | 8:00AM - 11:15AM
Adaptive Responses to Tissue Stress
Room: Peaks 4 & 5


Coffee Break

Wednesday, January 24 | 8:00AM - 11:15AM
Adaptive Responses to Tissue Stress
Room: Peaks 4 & 5

Speaker 5 of 7
Mathieu JM Bertrand, VIB / Ghent University, Belgium
Cell Death Checkpoints in TNF Signaling

Wednesday, January 24 | 8:00AM - 11:15AM
Adaptive Responses to Tissue Stress
Room: Peaks 4 & 5

Speaker 6 of 7
Henning Walczak, University College London, Cancer Institute, UK
Deficiency in LUBAC Components: A Surprise in Three Acts

Wednesday, January 24 | 8:00AM - 11:15AM
Adaptive Responses to Tissue Stress
Room: Peaks 4 & 5

Speaker 7 of 7
Andreas Villunger, Medical University Innsbruck, Austria
The Resurrection of the PIDDosome


Wednesday, January 24 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, January 24 | 2:30PM - 4:30PM
Workshop: Signaling in Cell Death and Inflammation
Room: Peaks 4 & 5

Speaker 1 of 8
* Pascal Meier, Institute of Cancer Research, UK

Wednesday, January 24 | 2:30PM - 4:30PM
Workshop: Signaling in Cell Death and Inflammation
Room: Peaks 4 & 5

Speaker 2 of 8
Aditya Murthy, Genentech, Inc., USA
Selective Autophagy of the Innate Adaptor TRIF Regulates Inflammatory Signaling

Wednesday, January 24 | 2:30PM - 4:30PM
Workshop: Signaling in Cell Death and Inflammation
Room: Peaks 4 & 5

Speaker 3 of 8
Piya Ghose, Rockefeller University, USA
The Fusogen EFF-1 Drives Phagosome Sealing during Dismantling of Morphologically Complex Cells

Wednesday, January 24 | 2:30PM - 4:30PM
Workshop: Signaling in Cell Death and Inflammation
Room: Peaks 4 & 5

Speaker 4 of 8
Mausita Karmakar, Case Western Reserve University, USA
An Alternate Role for Neutrophil GasderminD (GSDMD) in Mediating Caspase-1 Activation and IL-1 Release in the Absence of Pyroptosis

Wednesday, January 24 | 2:30PM - 4:30PM
Workshop: Signaling in Cell Death and Inflammation
Room: Peaks 4 & 5

Speaker 5 of 8
Huibing Wang, Harvard Medical School, USA
PELI1 Functions as a Dual Modulator of Necroptosis and Apoptosis by Mediating Ubiquitination of RIPK1 and Regulating the mRNA Levels of c-FLIP

Wednesday, January 24 | 2:30PM - 4:30PM
Workshop: Signaling in Cell Death and Inflammation
Room: Peaks 4 & 5

Speaker 6 of 8
Justin Shaun Arnold Perry, University of Virginia, USA
A Chloride Sensing Pathway Regulates Phagocyte Volume Homeostasis and the Inflammatory Switch

Wednesday, January 24 | 2:30PM - 4:30PM
Workshop: Signaling in Cell Death and Inflammation
Room: Peaks 4 & 5

Speaker 7 of 8
Andrew J. Davidson, University of Bristol, UK
An Irrepressible Appetite: Gnawing Away at the Robustness Underlying Macrophage Phagocytosis

Wednesday, January 24 | 2:30PM - 4:30PM
Workshop: Signaling in Cell Death and Inflammation
Room: Peaks 4 & 5

Speaker 8 of 8
Michael Alan Davis, University of Washington, USA
Pyroptotic Cell Swelling: A New Model of Inflammation Initiation Independent of Osmotic Lysis

Wednesday, January 24 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, January 24 | 5:00PM - 7:00PM
Death-Induced Tissue Remodeling
Room: Peaks 4 & 5

Speaker 1 of 5
* Mary A. Logan, Oregon Health & Science University, USA

Wednesday, January 24 | 5:00PM - 7:00PM
Death-Induced Tissue Remodeling
Room: Peaks 4 & 5

Speaker 2 of 5
Andreas Bergmann, University of Massachusetts Medical School, USA
Non-apoptotic Roles of Caspases for Proliferation and Cancer in Drosophila

Wednesday, January 24 | 5:00PM - 7:00PM
Death-Induced Tissue Remodeling
Room: Peaks 4 & 5

Speaker 3 of 5
Laura A. Johnston, Columbia University, USA
Spatially Restricted Signal Activation during Myc-induced Super-Competition

Wednesday, January 24 | 5:00PM - 7:00PM
Death-Induced Tissue Remodeling
Room: Peaks 4 & 5

Speaker 4 of 5
Shruti Singla, University of Cambridge, UK
Short Talk: Elimination of Aneuploid Cells in the Early Mammalian Embryo

Wednesday, January 24 | 5:00PM - 7:00PM
Death-Induced Tissue Remodeling
Room: Peaks 4 & 5

Speaker 5 of 5
Michael Overholtzer, Memorial Sloan Kettering Cancer Center, USA
LC3 Lipidation in LAP-Related Processes

Wednesday, January 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3
No registration fees are used to fund alcohol served at this function.

Thursday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Thursday, January 25 | 8:00AM - 11:15AM
Resolution and Healing
Room: Peaks 4 & 5

Speaker 1 of 8
* Eric H. Baehrecke, University of Massachusetts Medical School, USA

Thursday, January 25 | 8:00AM - 11:15AM
Resolution and Healing
Room: Peaks 4 & 5

Speaker 2 of 8
* Will Wood, University of Edinburgh, UK
Detecting Death and Damage; Understanding Macrophage Migration in Drosophila

Thursday, January 25 | 8:00AM - 11:15AM
Resolution and Healing
Room: Peaks 4 & 5

Speaker 3 of 8
Mary A. Logan, Oregon Health & Science University, USA
Genetic Regulation of Glial Cell Migration following Nerve Injury in Drosophila

Thursday, January 25 | 8:00AM - 11:15AM
Resolution and Healing
Room: Peaks 4 & 5


Coffee Break

Thursday, January 25 | 8:00AM - 11:15AM
Resolution and Healing
Room: Peaks 4 & 5

Speaker 5 of 8
Christopher D. Gregory, University of Edinburgh, UK
Sinister Self-Sacrifice: Contributions of Apoptosis to Malignant Disease

Thursday, January 25 | 8:00AM - 11:15AM
Resolution and Healing
Room: Peaks 4 & 5

Speaker 6 of 8
Jennifer Martinez, NIEHS, National Institutes of Health, USA
Short Talk: Non-Canonical Autophagy Mediates Immunosuppression during Challenge

Thursday, January 25 | 8:00AM - 11:15AM
Resolution and Healing
Room: Peaks 4 & 5

Speaker 7 of 8
Danielle Sliter, NINDS, National Institutes of Health, USA
Short Talk: Parkin, PINK1 and Inflammation

Thursday, January 25 | 8:00AM - 11:15AM
Resolution and Healing
Room: Peaks 4 & 5

Speaker 8 of 8
Kodi S. Ravichandran, University of Virginia, USA
Eating a Good Apoptotic Meal: Implications for Health and Disease

Thursday, January 25 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, January 25 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, January 25 | 5:00PM - 6:15PM
Immune Response Against Dying Tumor Cells
Room: Peaks 4 & 5

Speaker 1 of 4
* Kim Newton, Genentech, Inc., USA

Thursday, January 25 | 5:00PM - 6:15PM
Immune Response Against Dying Tumor Cells
Room: Peaks 4 & 5

Speaker 2 of 4
Matthew L. Albert, Genentech, Inc., USA
Apoptotic Cell-Mediated Antigen Presentation

Thursday, January 25 | 5:00PM - 6:15PM
Immune Response Against Dying Tumor Cells
Room: Peaks 4 & 5

Speaker 3 of 4
Scott Cameron, Novartis Institutes for BioMedical Research, USA
Clinical Experience with an IAP Antagonist, LCL161

Thursday, January 25 | 5:00PM - 6:15PM
Immune Response Against Dying Tumor Cells
Room: Peaks 4 & 5

Speaker 4 of 4
Marcus Conrad, Helmholtz Zentrum München, Germany
Short Talk: Mechanisms Controlling Ferroptotic Cell Death

Thursday, January 25 | 6:15PM - 7:00PM
Keynote Address
Room: Peaks 4 & 5

Speaker 1 of 3
* Pascal Meier, Institute of Cancer Research, UK

Thursday, January 25 | 6:15PM - 7:00PM
Keynote Address
Room: Peaks 4 & 5

Speaker 2 of 3
* Eric H. Baehrecke, University of Massachusetts Medical School, USA

Thursday, January 25 | 6:15PM - 7:00PM
Keynote Address
Room: Peaks 4 & 5

Speaker 3 of 3
Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
Towards Targeting MCL-1 for Cancer Therapy


Thursday, January 25 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Peaks 4 & 5


Thursday, January 25 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Peaks 1-3
No registration fees are used to fund alcohol served at this function.

Thursday, January 25 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 1-3
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 25 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 1-3


Friday, January 26 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.