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Web Desc
Ubiquitin Signaling Organizer(s): David Komander and Sylvie Urbé Date: January 28 - February 01, 2018 Location: Granlibakken Tahoe, Tahoe City, CA, USA Sponsored by Cell Research For important information on the coronavirus, please click here Summary of Meeting: These are exciting times for ubiquitin research: potential targets for small molecule inhibitors are emerging in a variety of human diseases and being exploited by the pharmaceutical industry. At the same time, new enzymes regulating ubiquitin modifications are still being discovered, and the complexity of ubiquitin modifications continues to increase with the emerging cross-talk between post-translational modifications. This conference will focus on the latest insights in the large area of cellular regulation mediated by ubiquitin and ubiquitin-like modifiers. Key goals are to provide overviews and updates on emerging frontiers, and encourage efforts to exploit the ubiquitin system to provide new treatments for human diseases. Rather than being organized around key enzymes in the cascade, sessions will focus on biological areas, ensuring a balanced mix of mechanistic and physiology aspects. The meeting will feature both key opinion leaders on ubiquitination who are known to present unpublished results and leading researchers from peripheral fields who will contribute new ideas. A short selection of company-associated academic speakers will provide insights into the translational opportunities in this area. Scholarship Deadline: October 2 2017 Discounted Abstract Deadline: October 2 2017 Abstract Deadline: October 31 2017 Discounted Registration Deadline: December 1 2017 Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested. Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Genentech, Inc. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Ubiquitin Signaling

Organizer(s): David Komander and Sylvie Urbé

Date: January 28 - February 01, 2018
Location: Granlibakken Tahoe, Tahoe City, CA, USA

Program


Sunday, January 28 \| 4:00PM - 8:00PM Arrival and Registration Room: Pre Function
Sunday, January 28 \| 6:00PM - 8:00PM Welcome Mixer Room: Granhall No registration fees are used to fund alcohol served at this function.
Sunday, January 28 \| 6:00PM - 8:00PM Light Meal - Provided by Granlibakken Room: Granhall
Monday, January 29 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Monday, January 29 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Mountain/Lake Speaker 1 of 2 * David Komander, Walter and Eliza Hall Institute of Medical Research, Australia
Monday, January 29 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Mountain/Lake Speaker 2 of 2 Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany Celebrating 20 Years of Cullin Neddylation
Monday, January 29 \| 9:00AM - 11:30AM The Ubiquitin Code I - Ubiquitin Chains Room: Mountain/Lake Speaker 1 of 7 * David Komander, Walter and Eliza Hall Institute of Medical Research, Australia
Monday, January 29 \| 9:00AM - 11:30AM The Ubiquitin Code I - Ubiquitin Chains Room: Mountain/Lake Speaker 2 of 7 Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research, Switzerland How Thalidomide Analogues Recruit Zinc-Finger Degrons to the CRL4-CRBN Ubiquitin Ligase
Monday, January 29 \| 9:00AM - 11:30AM The Ubiquitin Code I - Ubiquitin Chains Room: Mountain/Lake Coffee Break
Monday, January 29 \| 9:00AM - 11:30AM The Ubiquitin Code I - Ubiquitin Chains Room: Mountain/Lake Speaker 4 of 7 David Toczyski, University of California, San Francisco, USA Genetic Analysis Reveals Functions of Atypical Polyubiquitin Chains
Monday, January 29 \| 9:00AM - 11:30AM The Ubiquitin Code I - Ubiquitin Chains Room: Mountain/Lake Speaker 5 of 7 Steve Cappell, NCI, National Institutes of Health, USA Short Talk: Emi1 Switches from being a Substrate to an Inhibitor of APC/C-Cdh1 to Start the Cell Cycle
Monday, January 29 \| 9:00AM - 11:30AM The Ubiquitin Code I - Ubiquitin Chains Room: Mountain/Lake Speaker 6 of 7 Achim Werner, NIDCR, National Institutes of Health, USA Short Talk: Multisite Phosphorylation Regulates Ubiquitin-dependent Neural Crest Formation
Monday, January 29 \| 9:00AM - 11:30AM The Ubiquitin Code I - Ubiquitin Chains Room: Mountain/Lake Speaker 7 of 7 Raymond J. Deshaies, California Institute of Technology and Cleave Biosciences, USA Vms1/Ankzf1: A Novel Peptidyl-tRNA Hydrolase that Releases Nascent Chains from Stalled Ribosomes
Monday, January 29 \| 11:30AM - 5:00PM On Own for Lunch
Monday, January 29 \| 11:30AM - 1:00PM Poster Setup Room: Bay
Monday, January 29 \| 1:00PM - 10:00PM Poster Viewing Room: Bay
Monday, January 29 \| 2:30PM - 4:30PM Workshop 1: New Methods Room: Mountain/Lake Speaker 1 of 6 * Ingrid E. Wertz, Genentech, Inc., USA Reactive Site-centric Chemoproteomics Identifies a Structurally Distinct Class of Deubiquitinase Enzymes
Monday, January 29 \| 2:30PM - 4:30PM Workshop 1: New Methods Room: Mountain/Lake Speaker 2 of 6 Norihito Shibata, National Institute of Health Sciences, Japan Strategy for Protein Degradation against Oncoprotein BCR-ABL
Monday, January 29 \| 2:30PM - 4:30PM Workshop 1: New Methods Room: Mountain/Lake Speaker 3 of 6 Kristin Riching, Promega Corporation, USA Monitoring Functional Mechanisms of Protein Degradation in Living Cells
Monday, January 29 \| 2:30PM - 4:30PM Workshop 1: New Methods Room: Mountain/Lake Speaker 4 of 6 Yu Ye, University of Cambridge, UK Targeting Protein Aggregates with the Proteasome in vitro and in vivo
Monday, January 29 \| 2:30PM - 4:30PM Workshop 1: New Methods Room: Mountain/Lake Speaker 5 of 6 Itay Koren, Bar Ilan University, Israel Discovering Degrons using a Synthetic Human Peptidome
Monday, January 29 \| 2:30PM - 4:30PM Workshop 1: New Methods Room: Mountain/Lake Speaker 6 of 6 * Benedikt M. Kessler, University of Oxford, UK Expanding the Cancer Cell DUBome for Small Molecule Drug Profiling using Advanced Chemoproteomics
Monday, January 29 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Monday, January 29 \| 5:00PM - 7:00PM The Ubiquitin Code II - Ub/Ubl Modifications Room: Mountain/Lake Speaker 1 of 5 * Sylvie Urbé, University of Liverpool, UK
Monday, January 29 \| 5:00PM - 7:00PM The Ubiquitin Code II - Ub/Ubl Modifications Room: Mountain/Lake Speaker 2 of 5 Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA Ubiquitin-like Protein Conjugation Complexes and Genome Integrity
Monday, January 29 \| 5:00PM - 7:00PM The Ubiquitin Code II - Ub/Ubl Modifications Room: Mountain/Lake Speaker 3 of 5 Jon Huibregtse, University of Texas at Austin, USA The Extracellular Signaling Function of ISG15 and Cytokine Secretion
Monday, January 29 \| 5:00PM - 7:00PM The Ubiquitin Code II - Ub/Ubl Modifications Room: Mountain/Lake Speaker 4 of 5 Neil Hunter, University of California, Davis, USA Short Talk: Delineation and Analysis of the SUMO-Modified Proteome during Meiosis
Monday, January 29 \| 5:00PM - 7:00PM The Ubiquitin Code II - Ub/Ubl Modifications Room: Mountain/Lake Speaker 5 of 5 Mark W. Hochstrasser, Yale University, USA Distinct Toxin-Antidote Modules Underlie Reproductive Manipulation of Insect Hosts by Intracellular Wolbachia Bacteria
Monday, January 29 \| 7:00PM - 8:00PM Dinner Room: Granhall
Monday, January 29 \| 7:30PM - 10:00PM Poster Session 1 Room: Bay
Monday, January 29 \| 8:00PM - 9:00PM Social Hour Room: Bay
Tuesday, January 30 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Tuesday, January 30 \| 8:00AM - 11:15AM Ubiquitin in the Host's Response to Infection Room: Mountain/Lake Speaker 1 of 8 * Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany
Tuesday, January 30 \| 8:00AM - 11:15AM Ubiquitin in the Host's Response to Infection Room: Mountain/Lake Speaker 2 of 8 Vishva M. Dixit, Genentech, Inc., USA Ubiquitin in Inflammation
Tuesday, January 30 \| 8:00AM - 11:15AM Ubiquitin in the Host's Response to Infection Room: Mountain/Lake Speaker 3 of 8 Mads Gyrd-Hansen, University of Oxford, UK Deubiquitinases in Innate Immune Signalling
Tuesday, January 30 \| 8:00AM - 11:15AM Ubiquitin in the Host's Response to Infection Room: Mountain/Lake Coffee Break
Tuesday, January 30 \| 8:00AM - 11:15AM Ubiquitin in the Host's Response to Infection Room: Mountain/Lake Speaker 5 of 8 Catherine L. Day, University of Otago, New Zealand TRAFs and the Assembly of Ubiquitin Chains
Tuesday, January 30 \| 8:00AM - 11:15AM Ubiquitin in the Host's Response to Infection Room: Mountain/Lake Speaker 6 of 8 Nicolas Bidère, INSERM, France Short Talk: Regulation of Ciliogenesis and Cell Death by CYLD and Centriolar Satellites
Tuesday, January 30 \| 8:00AM - 11:15AM Ubiquitin in the Host's Response to Infection Room: Mountain/Lake Speaker 7 of 8 Fuminori Tokunaga, Osaka City University, Japan Short Talk: Characterization of a Novel LUBAC Inhibitor, HOIPIN-1
Tuesday, January 30 \| 8:00AM - 11:15AM Ubiquitin in the Host's Response to Infection Room: Mountain/Lake Speaker 8 of 8 Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA Ubiquitin in Host Responses
Tuesday, January 30 \| 11:15AM - 5:00PM On Own for Lunch
Tuesday, January 30 \| 11:15AM - 1:00PM Poster Setup Room: Bay
Tuesday, January 30 \| 1:00PM - 10:00PM Poster Viewing Room: Bay
Tuesday, January 30 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Tuesday, January 30 \| 5:00PM - 7:00PM Genetic Disorders Room: Mountain/Lake Speaker 1 of 5 * Agata Smogorzewska, Rockefeller University, USA
Tuesday, January 30 \| 5:00PM - 7:00PM Genetic Disorders Room: Mountain/Lake Speaker 2 of 5 Ivona Aksentijevich, NHGRI, National Institutes of Health, USA NF-kappaB Pathway in Autoinflammatory Diseases: Ubiquitination meets Autoinflammation
Tuesday, January 30 \| 5:00PM - 7:00PM Genetic Disorders Room: Mountain/Lake Speaker 3 of 5 Ryan Potts, St. Jude Children's Research Hospital, USA MAGE Proteins in Cancer
Tuesday, January 30 \| 5:00PM - 7:00PM Genetic Disorders Room: Mountain/Lake Speaker 4 of 5 Alessandra Rufini, University of Tor Vergata, Italy Short Talk: The E3 Ligase RNF126 as a New Therapeutic Target for Friedreich Ataxia
Tuesday, January 30 \| 5:00PM - 7:00PM Genetic Disorders Room: Mountain/Lake Speaker 5 of 5 Miratul Muqit, University of Dundee, UK Parkinson’s Disease Ubiquitin Signaling Pathways in Mice and Man
Tuesday, January 30 \| 7:00PM - 8:00PM Dinner Room: Granhall
Tuesday, January 30 \| 7:30PM - 10:00PM Poster Session 2 Room: Bay
Tuesday, January 30 \| 8:00PM - 9:00PM Social Hour Room: Bay No registration fees are used to fund alcohol served at this function.
Wednesday, January 31 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Wednesday, January 31 \| 8:00AM - 11:15AM Protein Degradation in Diseases Room: Mountain/Lake Speaker 1 of 8 * Mark W. Hochstrasser, Yale University, USA
Wednesday, January 31 \| 8:00AM - 11:15AM Protein Degradation in Diseases Room: Mountain/Lake Speaker 2 of 8 Daniel J. Finley, Harvard University and Proteostasis, Inc., USA Reciprocal Regulation between Ubp6 and the Proteasome
Wednesday, January 31 \| 8:00AM - 11:15AM Protein Degradation in Diseases Room: Mountain/Lake Speaker 3 of 8 Andreas Matouschek, University of Texas at Austin, USA Selecting Proteins for Proteasomal Degradation
Wednesday, January 31 \| 8:00AM - 11:15AM Protein Degradation in Diseases Room: Mountain/Lake Coffee Break
Wednesday, January 31 \| 8:00AM - 11:15AM Protein Degradation in Diseases Room: Mountain/Lake Speaker 5 of 8 Leo James, MRC Laboratory of Molecular Biology, UK Trim-Away: Targeted Degradation of Pathogens and Proteins by the Cytosolic Antibody Receptor TRIM21
Wednesday, January 31 \| 8:00AM - 11:15AM Protein Degradation in Diseases Room: Mountain/Lake Speaker 6 of 8 Sumana Sanyal, University of Hong Kong, Hong Kong Short Talk: Host Cellular Ubiquitylation Profiling Reveals a Critical Role for Lipid Droplet Metabolism during Flavivirus Infections
Wednesday, January 31 \| 8:00AM - 11:15AM Protein Degradation in Diseases Room: Mountain/Lake Speaker 7 of 8 John Hanna, Harvard Medical School, USA Short Talk: Targeted Degradation of Glucose Transporters Protects against Arsenic Toxicity
Wednesday, January 31 \| 8:00AM - 11:15AM Protein Degradation in Diseases Room: Mountain/Lake Speaker 8 of 8 Craig M. Crews, Yale University and Arvinas, Inc., USA PROTACs: Induced Protein Degradation as a Therapeutic Strategy
Wednesday, January 31 \| 11:15AM - 5:00PM On Own for Lunch
Wednesday, January 31 \| 11:15AM - 1:00PM Poster Setup Room: Bay
Wednesday, January 31 \| 1:00PM - 10:00PM Poster Viewing Room: Bay
Wednesday, January 31 \| 2:30PM - 4:30PM Workshop 2: Drug Discovery Room: Mountain/Lake Speaker 1 of 6 * Lawrence R. Dick, USA Targeting the Proteasome for Antimalarial Drug Discovery
Wednesday, January 31 \| 2:30PM - 4:30PM Workshop 2: Drug Discovery Room: Mountain/Lake Speaker 2 of 6 Thomas Kodadek, The Scripps Research Institute, USA Mining DNA-Encoded Combinatorial Libraries of Electrophilic Compounds for Selective, Covalent Inhibitors of Deubiquitylases
Wednesday, January 31 \| 2:30PM - 4:30PM Workshop 2: Drug Discovery Room: Mountain/Lake Speaker 3 of 6 Peter Tsvetkov, Broad Institute, USA A New Way Cancer Cells Cope with Proteotoxic Stress
Wednesday, January 31 \| 2:30PM - 4:30PM Workshop 2: Drug Discovery Room: Mountain/Lake Speaker 4 of 6 Panagiotis Ntziachristos, Northwestern University, USA USP7 Cooperates with Oncogenes to Drive the Oncogenic Transcriptional Program in Acute Lymphoblastic Leukemia
Wednesday, January 31 \| 2:30PM - 4:30PM Workshop 2: Drug Discovery Room: Mountain/Lake Speaker 5 of 6 Marjolein Kikkert, Leiden University Medical Center, Netherlands Potent and Selective Inhibition of MERS Coronavirus Papain-like Protease by Engineered Ubiquitin Variants
Wednesday, January 31 \| 2:30PM - 4:30PM Workshop 2: Drug Discovery Room: Mountain/Lake Speaker 6 of 6 * Jeanine Harrigan, Mission Therapeutics, UK Development of DUB Inhibitors for the Treatment of Human Disease
Wednesday, January 31 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Wednesday, January 31 \| 5:00PM - 7:00PM Regulation of Autophagy and Mitophagy by Ubiquitin Room: Mountain/Lake Speaker 1 of 5 * Miratul Muqit, University of Dundee, UK
Wednesday, January 31 \| 5:00PM - 7:00PM Regulation of Autophagy and Mitophagy by Ubiquitin Room: Mountain/Lake Speaker 2 of 5 Sylvie Urbé, University of Liverpool, UK Regulation of Basal Mitophagy by Deubiquitylases
Wednesday, January 31 \| 5:00PM - 7:00PM Regulation of Autophagy and Mitophagy by Ubiquitin Room: Mountain/Lake Speaker 3 of 5 J. Wade Harper, Harvard Medical School, USA Digitizing Ubiquitin Signaling for Mitophagy
Wednesday, January 31 \| 5:00PM - 7:00PM Regulation of Autophagy and Mitophagy by Ubiquitin Room: Mountain/Lake Speaker 4 of 5 Kalle Gehring, McGill University, Canada Short Talk: Parkin and PINK1 at the Crossroads of Cell Signaling by Phosphorylation and Ubiquitination
Wednesday, January 31 \| 5:00PM - 7:00PM Regulation of Autophagy and Mitophagy by Ubiquitin Room: Mountain/Lake Speaker 5 of 5 Richard J. Youle, NINDS, National Institutes of Health, USA Synthetic Phenotypes in Mice Lacking PINK1 and Parkin-Mediated Mitophagy
Wednesday, January 31 \| 7:00PM - 8:00PM Dinner Room: Granhall
Wednesday, January 31 \| 7:30PM - 10:00PM Poster Session 3 Room: Bay
Wednesday, January 31 \| 8:00PM - 9:00PM Social Hour Room: Bay No registration fees are used to fund alcohol served at this function.
Thursday, February 01 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Thursday, February 01 \| 8:00AM - 11:15AM Nuclear Roles of Ubiquitin Room: Mountain/Lake Speaker 1 of 7 Titia K. Sixma, Netherlands Cancer Institute, Netherlands Finding the Right Target
Thursday, February 01 \| 8:00AM - 11:15AM Nuclear Roles of Ubiquitin Room: Mountain/Lake Speaker 2 of 7 Niels Mailand, University of Copenhagen, Denmark Regulation of Chromatin Ubiquitylation in the DNA Damage Response
Thursday, February 01 \| 8:00AM - 11:15AM Nuclear Roles of Ubiquitin Room: Mountain/Lake Coffee Break
Thursday, February 01 \| 8:00AM - 11:15AM Nuclear Roles of Ubiquitin Room: Mountain/Lake Speaker 4 of 7 Agata Smogorzewska, Rockefeller University, USA Ubiquitin Shuttle Proteins and the Stress Response at the Replication Fork
Thursday, February 01 \| 8:00AM - 11:15AM Nuclear Roles of Ubiquitin Room: Mountain/Lake Speaker 5 of 7 John L. Nitiss, University of Illinois, USA Short Talk: Ubiquitylation Regulates Repair of Topoisomerase Induced DNA Damage
Thursday, February 01 \| 8:00AM - 11:15AM Nuclear Roles of Ubiquitin Room: Mountain/Lake Speaker 6 of 7 * Christine Katrin Schmidt, University of Manchester, UK Short Talk: Talk Title to be Announced
Thursday, February 01 \| 8:00AM - 11:15AM Nuclear Roles of Ubiquitin Room: Mountain/Lake Speaker 7 of 7 Cynthia Wolberger, Johns Hopkins University School of Medicine, USA Mechanistic Insights into Histone Deubiquitination
Thursday, February 01 \| 11:15AM - 5:00PM On Own for Lunch
Thursday, February 01 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Thursday, February 01 \| 5:00PM - 7:00PM New Paradigms in Ubiquitin Modification(s) Room: Mountain/Lake Speaker 1 of 5 * Sylvie Urbé, University of Liverpool, UK
Thursday, February 01 \| 5:00PM - 7:00PM New Paradigms in Ubiquitin Modification(s) Room: Mountain/Lake Speaker 2 of 5 Ivan Dikic, Goethe University Medical School, Germany Catalysis and Inhibition of Phosphoribosyl-Dependent Ubiquitination
Thursday, February 01 \| 5:00PM - 7:00PM New Paradigms in Ubiquitin Modification(s) Room: Mountain/Lake Speaker 3 of 5 Yuxin Mao, Cornell University, USA Short Talk: The Molecular Mechanism of Phosphoribosyl-ubiquitination Mediated by a Single Legionella Effector
Thursday, February 01 \| 5:00PM - 7:00PM New Paradigms in Ubiquitin Modification(s) Room: Mountain/Lake Speaker 4 of 5 Satpal Virdee, University of Dundee, UK A New Class of Threonine-specific E3 Ligase
Thursday, February 01 \| 5:00PM - 7:00PM New Paradigms in Ubiquitin Modification(s) Room: Mountain/Lake Speaker 5 of 5 David Komander, Walter and Eliza Hall Institute of Medical Research, Australia New Tools to Study Ubiquitin Chain Architecture
Thursday, February 01 \| 7:00PM - 7:15PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Mountain/Lake
Thursday, February 01 \| 7:15PM - 8:15PM Dinner Room: Granhall
Thursday, February 01 \| 7:15PM - 8:15PM Social Hour Room: Granhall No registration fees are used to fund alcohol served at this function.
Thursday, February 01 \| 8:00PM - 11:00PM Entertainment Room: Granhall Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, February 01 \| 8:00PM - 11:00PM Cash Bar Room: Granhall
Friday, February 02 \| 10:24AM - 10:24AM Departure *Session Chair †Invited, not yet responded.