Web Desc
Ubiquitin Signaling
Organizer(s): David Komander and Sylvie Urbé
Date: January 28 - February 01, 2018
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Sponsored by Cell Research
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Summary of Meeting:
These are exciting times for ubiquitin research: potential targets for small molecule inhibitors are emerging in a variety of human diseases and being exploited by the pharmaceutical industry. At the same time, new enzymes regulating ubiquitin modifications are still being discovered, and the complexity of ubiquitin modifications continues to increase with the emerging cross-talk between post-translational modifications. This conference will focus on the latest insights in the large area of cellular regulation mediated by ubiquitin and ubiquitin-like modifiers. Key goals are to provide overviews and updates on emerging frontiers, and encourage efforts to exploit the ubiquitin system to provide new treatments for human diseases. Rather than being organized around key enzymes in the cascade, sessions will focus on biological areas, ensuring a balanced mix of mechanistic and physiology aspects. The meeting will feature both key opinion leaders on ubiquitination who are known to present unpublished results and leading researchers from peripheral fields who will contribute new ideas. A short selection of company-associated academic speakers will provide insights into the translational opportunities in this area.
Scholarship Deadline: October 2 2017
Discounted Abstract Deadline: October 2 2017
Abstract Deadline: October 31 2017
Discounted Registration Deadline: December 1 2017
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Cell Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 28 | 4:00PM - 8:00PM
Arrival and Registration
Room: Pre Function


Sunday, January 28 | 6:00PM - 8:00PM
Welcome Mixer
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Sunday, January 28 | 6:00PM - 8:00PM
Light Meal - Provided by Granlibakken
Room: Granhall


Monday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, January 29 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Mountain/Lake

Speaker 1 of 2
* David Komander, Walter and Eliza Hall Institute of Medical Research, Australia

Monday, January 29 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Mountain/Lake

Speaker 2 of 2
Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Celebrating 20 Years of Cullin Neddylation

Monday, January 29 | 9:00AM - 11:30AM
The Ubiquitin Code I - Ubiquitin Chains
Room: Mountain/Lake

Speaker 1 of 7
* David Komander, Walter and Eliza Hall Institute of Medical Research, Australia

Monday, January 29 | 9:00AM - 11:30AM
The Ubiquitin Code I - Ubiquitin Chains
Room: Mountain/Lake

Speaker 2 of 7
Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research, Switzerland
How Thalidomide Analogues Recruit Zinc-Finger Degrons to the CRL4-CRBN Ubiquitin Ligase

Monday, January 29 | 9:00AM - 11:30AM
The Ubiquitin Code I - Ubiquitin Chains
Room: Mountain/Lake


Coffee Break

Monday, January 29 | 9:00AM - 11:30AM
The Ubiquitin Code I - Ubiquitin Chains
Room: Mountain/Lake

Speaker 4 of 7
David Toczyski, University of California, San Francisco, USA
Genetic Analysis Reveals Functions of Atypical Polyubiquitin Chains

Monday, January 29 | 9:00AM - 11:30AM
The Ubiquitin Code I - Ubiquitin Chains
Room: Mountain/Lake

Speaker 5 of 7
Steve Cappell, NCI, National Institutes of Health, USA
Short Talk: Emi1 Switches from being a Substrate to an Inhibitor of APC/C-Cdh1 to Start the Cell Cycle

Monday, January 29 | 9:00AM - 11:30AM
The Ubiquitin Code I - Ubiquitin Chains
Room: Mountain/Lake

Speaker 6 of 7
Achim Werner, NIDCR, National Institutes of Health, USA
Short Talk: Multisite Phosphorylation Regulates Ubiquitin-dependent Neural Crest Formation

Monday, January 29 | 9:00AM - 11:30AM
The Ubiquitin Code I - Ubiquitin Chains
Room: Mountain/Lake

Speaker 7 of 7
Raymond J. Deshaies, California Institute of Technology and Cleave Biosciences, USA
Vms1/Ankzf1: A Novel Peptidyl-tRNA Hydrolase that Releases Nascent Chains from Stalled Ribosomes

Monday, January 29 | 11:30AM - 5:00PM
On Own for Lunch


Monday, January 29 | 11:30AM - 1:00PM
Poster Setup
Room: Bay


Monday, January 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, January 29 | 2:30PM - 4:30PM
Workshop 1: New Methods
Room: Mountain/Lake

Speaker 1 of 6
* Ingrid E. Wertz, Genentech, Inc., USA
Reactive Site-centric Chemoproteomics Identifies a Structurally Distinct Class of Deubiquitinase Enzymes

Monday, January 29 | 2:30PM - 4:30PM
Workshop 1: New Methods
Room: Mountain/Lake

Speaker 2 of 6
Norihito Shibata, National Institute of Health Sciences, Japan
Strategy for Protein Degradation against Oncoprotein BCR-ABL

Monday, January 29 | 2:30PM - 4:30PM
Workshop 1: New Methods
Room: Mountain/Lake

Speaker 3 of 6
Kristin Riching, Promega Corporation, USA
Monitoring Functional Mechanisms of Protein Degradation in Living Cells

Monday, January 29 | 2:30PM - 4:30PM
Workshop 1: New Methods
Room: Mountain/Lake

Speaker 4 of 6
Yu Ye, University of Cambridge, UK
Targeting Protein Aggregates with the Proteasome in vitro and in vivo

Monday, January 29 | 2:30PM - 4:30PM
Workshop 1: New Methods
Room: Mountain/Lake

Speaker 5 of 6
Itay Koren, Bar Ilan University, Israel
Discovering Degrons using a Synthetic Human Peptidome

Monday, January 29 | 2:30PM - 4:30PM
Workshop 1: New Methods
Room: Mountain/Lake

Speaker 6 of 6
* Benedikt M. Kessler, University of Oxford, UK
Expanding the Cancer Cell DUBome for Small Molecule Drug Profiling using Advanced Chemoproteomics

Monday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, January 29 | 5:00PM - 7:00PM
The Ubiquitin Code II - Ub/Ubl Modifications
Room: Mountain/Lake

Speaker 1 of 5
* Sylvie Urbé, University of Liverpool, UK

Monday, January 29 | 5:00PM - 7:00PM
The Ubiquitin Code II - Ub/Ubl Modifications
Room: Mountain/Lake

Speaker 2 of 5
Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA
Ubiquitin-like Protein Conjugation Complexes and Genome Integrity

Monday, January 29 | 5:00PM - 7:00PM
The Ubiquitin Code II - Ub/Ubl Modifications
Room: Mountain/Lake

Speaker 3 of 5
Jon Huibregtse, University of Texas at Austin, USA
The Extracellular Signaling Function of ISG15 and Cytokine Secretion


Monday, January 29 | 5:00PM - 7:00PM
The Ubiquitin Code II - Ub/Ubl Modifications
Room: Mountain/Lake

Speaker 4 of 5
Neil Hunter, University of California, Davis, USA
Short Talk: Delineation and Analysis of the SUMO-Modified Proteome during Meiosis

Monday, January 29 | 5:00PM - 7:00PM
The Ubiquitin Code II - Ub/Ubl Modifications
Room: Mountain/Lake

Speaker 5 of 5
Mark W. Hochstrasser, Yale University, USA
Distinct Toxin-Antidote Modules Underlie Reproductive Manipulation of Insect Hosts by Intracellular Wolbachia Bacteria

Monday, January 29 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, January 29 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay


Monday, January 29 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Tuesday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, January 30 | 8:00AM - 11:15AM
Ubiquitin in the Host's Response to Infection
Room: Mountain/Lake

Speaker 1 of 8
* Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany

Tuesday, January 30 | 8:00AM - 11:15AM
Ubiquitin in the Host's Response to Infection
Room: Mountain/Lake

Speaker 2 of 8
Vishva M. Dixit, Genentech, Inc., USA
Ubiquitin in Inflammation

Tuesday, January 30 | 8:00AM - 11:15AM
Ubiquitin in the Host's Response to Infection
Room: Mountain/Lake

Speaker 3 of 8
Mads Gyrd-Hansen, University of Oxford, UK
Deubiquitinases in Innate Immune Signalling


Tuesday, January 30 | 8:00AM - 11:15AM
Ubiquitin in the Host's Response to Infection
Room: Mountain/Lake


Coffee Break

Tuesday, January 30 | 8:00AM - 11:15AM
Ubiquitin in the Host's Response to Infection
Room: Mountain/Lake

Speaker 5 of 8
Catherine L. Day, University of Otago, New Zealand
TRAFs and the Assembly of Ubiquitin Chains

Tuesday, January 30 | 8:00AM - 11:15AM
Ubiquitin in the Host's Response to Infection
Room: Mountain/Lake

Speaker 6 of 8
Nicolas Bidère, INSERM, France
Short Talk: Regulation of Ciliogenesis and Cell Death by CYLD and Centriolar Satellites

Tuesday, January 30 | 8:00AM - 11:15AM
Ubiquitin in the Host's Response to Infection
Room: Mountain/Lake

Speaker 7 of 8
Fuminori Tokunaga, Osaka City University, Japan
Short Talk: Characterization of a Novel LUBAC Inhibitor, HOIPIN-1

Tuesday, January 30 | 8:00AM - 11:15AM
Ubiquitin in the Host's Response to Infection
Room: Mountain/Lake

Speaker 8 of 8
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Ubiquitin in Host Responses

Tuesday, January 30 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, January 30 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, January 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, January 30 | 5:00PM - 7:00PM
Genetic Disorders
Room: Mountain/Lake

Speaker 1 of 5
* Agata Smogorzewska, Rockefeller University, USA

Tuesday, January 30 | 5:00PM - 7:00PM
Genetic Disorders
Room: Mountain/Lake

Speaker 2 of 5
Ivona Aksentijevich, NHGRI, National Institutes of Health, USA
NF-kappaB Pathway in Autoinflammatory Diseases: Ubiquitination meets Autoinflammation

Tuesday, January 30 | 5:00PM - 7:00PM
Genetic Disorders
Room: Mountain/Lake

Speaker 3 of 5
Ryan Potts, St. Jude Children's Research Hospital, USA
MAGE Proteins in Cancer

Tuesday, January 30 | 5:00PM - 7:00PM
Genetic Disorders
Room: Mountain/Lake

Speaker 4 of 5
Alessandra Rufini, University of Tor Vergata, Italy
Short Talk: The E3 Ligase RNF126 as a New Therapeutic Target for Friedreich Ataxia

Tuesday, January 30 | 5:00PM - 7:00PM
Genetic Disorders
Room: Mountain/Lake

Speaker 5 of 5
Miratul Muqit, University of Dundee, UK
Parkinson’s Disease Ubiquitin Signaling Pathways in Mice and Man

Tuesday, January 30 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, January 30 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay


Tuesday, January 30 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Wednesday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, January 31 | 8:00AM - 11:15AM
Protein Degradation in Diseases
Room: Mountain/Lake

Speaker 1 of 8
* Mark W. Hochstrasser, Yale University, USA

Wednesday, January 31 | 8:00AM - 11:15AM
Protein Degradation in Diseases
Room: Mountain/Lake

Speaker 2 of 8
Daniel J. Finley, Harvard University and Proteostasis, Inc., USA
Reciprocal Regulation between Ubp6 and the Proteasome

Wednesday, January 31 | 8:00AM - 11:15AM
Protein Degradation in Diseases
Room: Mountain/Lake

Speaker 3 of 8
Andreas Matouschek, University of Texas at Austin, USA
Selecting Proteins for Proteasomal Degradation

Wednesday, January 31 | 8:00AM - 11:15AM
Protein Degradation in Diseases
Room: Mountain/Lake


Coffee Break

Wednesday, January 31 | 8:00AM - 11:15AM
Protein Degradation in Diseases
Room: Mountain/Lake

Speaker 5 of 8
Leo James, MRC Laboratory of Molecular Biology, UK
Trim-Away: Targeted Degradation of Pathogens and Proteins by the Cytosolic Antibody Receptor TRIM21

Wednesday, January 31 | 8:00AM - 11:15AM
Protein Degradation in Diseases
Room: Mountain/Lake

Speaker 6 of 8
Sumana Sanyal, University of Hong Kong, Hong Kong
Short Talk: Host Cellular Ubiquitylation Profiling Reveals a Critical Role for Lipid Droplet Metabolism during Flavivirus Infections

Wednesday, January 31 | 8:00AM - 11:15AM
Protein Degradation in Diseases
Room: Mountain/Lake

Speaker 7 of 8
John Hanna, Harvard Medical School, USA
Short Talk: Targeted Degradation of Glucose Transporters Protects against Arsenic Toxicity

Wednesday, January 31 | 8:00AM - 11:15AM
Protein Degradation in Diseases
Room: Mountain/Lake

Speaker 8 of 8
Craig M. Crews, Yale University and Arvinas, Inc., USA
PROTACs: Induced Protein Degradation as a Therapeutic Strategy

Wednesday, January 31 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, January 31 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Wednesday, January 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Wednesday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery
Room: Mountain/Lake

Speaker 1 of 6
* Lawrence R. Dick, USA
Targeting the Proteasome for Antimalarial Drug Discovery

Wednesday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery
Room: Mountain/Lake

Speaker 2 of 6
Thomas Kodadek, The Scripps Research Institute, USA
Mining DNA-Encoded Combinatorial Libraries of Electrophilic Compounds for Selective, Covalent Inhibitors of Deubiquitylases

Wednesday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery
Room: Mountain/Lake

Speaker 3 of 6
Peter Tsvetkov, Broad Institute, USA
A New Way Cancer Cells Cope with Proteotoxic Stress

Wednesday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery
Room: Mountain/Lake

Speaker 4 of 6
Panagiotis Ntziachristos, Northwestern University, USA
USP7 Cooperates with Oncogenes to Drive the Oncogenic Transcriptional Program in Acute Lymphoblastic Leukemia

Wednesday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery
Room: Mountain/Lake

Speaker 5 of 6
Marjolein Kikkert, Leiden University Medical Center, Netherlands
Potent and Selective Inhibition of MERS Coronavirus Papain-like Protease by Engineered Ubiquitin Variants

Wednesday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery
Room: Mountain/Lake

Speaker 6 of 6
* Jeanine Harrigan, Mission Therapeutics, UK
Development of DUB Inhibitors for the Treatment of Human Disease

Wednesday, January 31 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, January 31 | 5:00PM - 7:00PM
Regulation of Autophagy and Mitophagy by Ubiquitin
Room: Mountain/Lake

Speaker 1 of 5
* Miratul Muqit, University of Dundee, UK

Wednesday, January 31 | 5:00PM - 7:00PM
Regulation of Autophagy and Mitophagy by Ubiquitin
Room: Mountain/Lake

Speaker 2 of 5
Sylvie Urbé, University of Liverpool, UK
Regulation of Basal Mitophagy by Deubiquitylases

Wednesday, January 31 | 5:00PM - 7:00PM
Regulation of Autophagy and Mitophagy by Ubiquitin
Room: Mountain/Lake

Speaker 3 of 5
J. Wade Harper, Harvard Medical School, USA
Digitizing Ubiquitin Signaling for Mitophagy

Wednesday, January 31 | 5:00PM - 7:00PM
Regulation of Autophagy and Mitophagy by Ubiquitin
Room: Mountain/Lake

Speaker 4 of 5
Kalle Gehring, McGill University, Canada
Short Talk: Parkin and PINK1 at the Crossroads of Cell Signaling by Phosphorylation and Ubiquitination

Wednesday, January 31 | 5:00PM - 7:00PM
Regulation of Autophagy and Mitophagy by Ubiquitin
Room: Mountain/Lake

Speaker 5 of 5
Richard J. Youle, NINDS, National Institutes of Health, USA
Synthetic Phenotypes in Mice Lacking PINK1 and Parkin-Mediated Mitophagy

Wednesday, January 31 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Wednesday, January 31 | 7:30PM - 10:00PM
Poster Session 3
Room: Bay


Wednesday, January 31 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Thursday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, February 01 | 8:00AM - 11:15AM
Nuclear Roles of Ubiquitin
Room: Mountain/Lake

Speaker 1 of 7
Titia K. Sixma, Netherlands Cancer Institute, Netherlands
Finding the Right Target

Thursday, February 01 | 8:00AM - 11:15AM
Nuclear Roles of Ubiquitin
Room: Mountain/Lake

Speaker 2 of 7
Niels Mailand, University of Copenhagen, Denmark
Regulation of Chromatin Ubiquitylation in the DNA Damage Response

Thursday, February 01 | 8:00AM - 11:15AM
Nuclear Roles of Ubiquitin
Room: Mountain/Lake


Coffee Break

Thursday, February 01 | 8:00AM - 11:15AM
Nuclear Roles of Ubiquitin
Room: Mountain/Lake

Speaker 4 of 7
Agata Smogorzewska, Rockefeller University, USA
Ubiquitin Shuttle Proteins and the Stress Response at the Replication Fork

Thursday, February 01 | 8:00AM - 11:15AM
Nuclear Roles of Ubiquitin
Room: Mountain/Lake

Speaker 5 of 7
John L. Nitiss, University of Illinois, USA
Short Talk: Ubiquitylation Regulates Repair of Topoisomerase Induced DNA Damage

Thursday, February 01 | 8:00AM - 11:15AM
Nuclear Roles of Ubiquitin
Room: Mountain/Lake

Speaker 6 of 7
* Christine Katrin Schmidt, University of Manchester, UK
Short Talk: Talk Title to be Announced

Thursday, February 01 | 8:00AM - 11:15AM
Nuclear Roles of Ubiquitin
Room: Mountain/Lake

Speaker 7 of 7
Cynthia Wolberger, Johns Hopkins University School of Medicine, USA
Mechanistic Insights into Histone Deubiquitination

Thursday, February 01 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, February 01 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Thursday, February 01 | 5:00PM - 7:00PM
New Paradigms in Ubiquitin Modification(s)
Room: Mountain/Lake

Speaker 1 of 5
* Sylvie Urbé, University of Liverpool, UK

Thursday, February 01 | 5:00PM - 7:00PM
New Paradigms in Ubiquitin Modification(s)
Room: Mountain/Lake

Speaker 2 of 5
Ivan Dikic, Goethe University Medical School, Germany
Catalysis and Inhibition of Phosphoribosyl-Dependent Ubiquitination

Thursday, February 01 | 5:00PM - 7:00PM
New Paradigms in Ubiquitin Modification(s)
Room: Mountain/Lake

Speaker 3 of 5
Yuxin Mao, Cornell University, USA
Short Talk: The Molecular Mechanism of Phosphoribosyl-ubiquitination Mediated by a Single Legionella Effector

Thursday, February 01 | 5:00PM - 7:00PM
New Paradigms in Ubiquitin Modification(s)
Room: Mountain/Lake

Speaker 4 of 5
Satpal Virdee, University of Dundee, UK
A New Class of Threonine-specific E3 Ligase

Thursday, February 01 | 5:00PM - 7:00PM
New Paradigms in Ubiquitin Modification(s)
Room: Mountain/Lake

Speaker 5 of 5
David Komander, Walter and Eliza Hall Institute of Medical Research, Australia
New Tools to Study Ubiquitin Chain Architecture

Thursday, February 01 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Mountain/Lake


Thursday, February 01 | 7:15PM - 8:15PM
Dinner
Room: Granhall


Thursday, February 01 | 7:15PM - 8:15PM
Social Hour
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Thursday, February 01 | 8:00PM - 11:00PM
Entertainment
Room: Granhall
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, February 01 | 8:00PM - 11:00PM
Cash Bar
Room: Granhall


Friday, February 02 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.