Web Desc
Translational Systems Immunology
Organizer(s): Sally John, Soumya Raychaudhuri, Michael Vincent and Mark M. Davis
Date: January 28 - February 01, 2018
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by AbbVie Inc., Biogen, Bioverativ Therapeutics, Merck & Co., Inc. and Theravance Biopharma
Summary of Meeting:
Advances in large-scale data acquisition, immune phenotyping and computational biology are transforming immunology research and allowing unprecedented insights into the networks, pathways and systems that influence human health and disease. This conference will cover the exciting technology advances that are enhancing our ability to elucidate human immune function and networks as well as practical applications in drug and biomarker discovery and patient stratification. The meeting begins with a look at progress in human genetics and the use of sequencing to assign functional mutations to rare human immune phenotypes. The impact of common variants on immune function requires larger sample sizes, and speakers will cover how genome-wide high-throughput genomics in combination with detailed phenotyping and physiologically relevant perturbations are providing foundational data sets that allow an unbiased view of immune function in cells and tissues. Also discussed will be emerging computational and analytical methods that enable integration and interpretation of high-content molecular data. The meeting will then move on to look at the application of these technological advances, expanding investigation to study the immune response in tissues and organs to enable a deeper understanding of interaction between immune and non-immune cells and their respective roles in disease states. Critical to clinical progress is the translation of systems immunology research into novel therapies and diagnostic or prognostic tests. Sessions themed around infectious disease and vaccine development advances in immune-oncology and patient stratification in complex disease and treatment response aim to provide depth from foundational science to clinical translation. Finally, a key goal is fostering collaboration across disciplines and the development of novel ideas. The meeting will be relevant for immunologists, computational biologists and clinicians with an interest in molecular characterization of the immune system.
Scholarship Deadline: October 2 2017
Discounted Abstract Deadline: October 2 2017
Abstract Deadline: October 31 2017
Discounted Registration Deadline: December 1 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AbbVie Inc.BiogenBioverativ TherapeuticsMerck & Co., Inc.Theravance Biopharma
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Pfizer Research Technology Center
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI136444-01
Funding for this conference was made possible (in part) by 1 R13 AI136444-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 28 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Sunday, January 28 | 6:00PM - 8:00PM
Welcome Mixer
Room: Ballroom Lobby
No registration fees are used to fund alcohol served at this function.

Monday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, January 29 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Ballroom 1-2

Speaker 2 of 2
Sarah Teichmann, Wellcome Sanger Institute, UK
Immunogenomics One Cell at a Time

Monday, January 29 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Ballroom 1-2

Speaker 1 of 2
* Sally John, Biogen, USA

Monday, January 29 | 9:00AM - 11:30AM
Human Phenotypic Validation via Rare Genetic Mutations
Room: Ballroom 1-2
Unbiased exome sequencing in Mendelian phenotypes followed by functional annotation of variants are providing unique and direct insights into the function of human immune genes.
Speaker 7 of 7
Michael P. O'Connell, NIAID, National Institutes of Health, USA
Short Talk: EXTL1- and NDST2-mediated Regulation of Allergic Disease

Monday, January 29 | 9:00AM - 11:30AM
Human Phenotypic Validation via Rare Genetic Mutations
Room: Ballroom 1-2
Unbiased exome sequencing in Mendelian phenotypes followed by functional annotation of variants are providing unique and direct insights into the function of human immune genes.
Speaker 6 of 7
Cecilia Dominguez Conde, CeMM/LBI-RUD, Austria
Short Talk: Insights into DOCK2 Deficiency through the Analysis of Protein Interactions

Monday, January 29 | 9:00AM - 11:30AM
Human Phenotypic Validation via Rare Genetic Mutations
Room: Ballroom 1-2
Unbiased exome sequencing in Mendelian phenotypes followed by functional annotation of variants are providing unique and direct insights into the function of human immune genes.
Speaker 5 of 7
Hakon Hakonarson, Children's Hospital of Philadelphia, USA
Exome Sequencing to Diagnosis and Treat Pediatric Immune Disease

Monday, January 29 | 9:00AM - 11:30AM
Human Phenotypic Validation via Rare Genetic Mutations
Room: Ballroom 1-2
Unbiased exome sequencing in Mendelian phenotypes followed by functional annotation of variants are providing unique and direct insights into the function of human immune genes.
Speaker 4 of 7
Helen C. Su, NIAID, National Institutes of Health, USA
Elucidating Molecular Mechanisms of a Novel Inherited Immunodeficiency-Immunodysregulation Disorder

Monday, January 29 | 9:00AM - 11:30AM
Human Phenotypic Validation via Rare Genetic Mutations
Room: Ballroom 1-2
Unbiased exome sequencing in Mendelian phenotypes followed by functional annotation of variants are providing unique and direct insights into the function of human immune genes.

Coffee Break

Monday, January 29 | 9:00AM - 11:30AM
Human Phenotypic Validation via Rare Genetic Mutations
Room: Ballroom 1-2
Unbiased exome sequencing in Mendelian phenotypes followed by functional annotation of variants are providing unique and direct insights into the function of human immune genes.
Speaker 2 of 7
Danish Saleheen, University of Pennsylvania, USA
Human Knockout Program

Monday, January 29 | 9:00AM - 11:30AM
Human Phenotypic Validation via Rare Genetic Mutations
Room: Ballroom 1-2
Unbiased exome sequencing in Mendelian phenotypes followed by functional annotation of variants are providing unique and direct insights into the function of human immune genes.
Speaker 1 of 7
* Sally John, Biogen, USA

Monday, January 29 | 11:30AM - 1:00PM
Poster Setup
Room: Ballroom 3


Monday, January 29 | 11:30AM - 5:00PM
On Own for Lunch


Monday, January 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom 3


Monday, January 29 | 2:30PM - 4:30PM
Workshop 1: Translation from Mice to Man: Friendly Debate
Room: Ballroom 1-2
How can we optimize our ability to translate observations between rodent and human immunology? Advances in human immune-profiling, and genetics now provides us with greater insight into the human immune system. In addition, several failures of therapeutic approaches in humans that had compelling pre-clinical evidence suggests we may have an opportunity to better understand the relationship between the mice and man immunology. The aim of this workshop will be to compare and contrast our knowledge of rodent and human immunology with a view to applying research methods to achieve optimally translatability between species. Selected short talks will highlight research approaches and the moderators will facilitate discussion that focuses us on an end goal of testing novel immunomodulatory mechanisms in humans.
Speaker 5 of 5
Adam Laing, King's College London, UK
Immune Parameters Are Constrained within a Multidimensional Shape that Describes Immune Competence

Monday, January 29 | 2:30PM - 4:30PM
Workshop 1: Translation from Mice to Man: Friendly Debate
Room: Ballroom 1-2
How can we optimize our ability to translate observations between rodent and human immunology? Advances in human immune-profiling, and genetics now provides us with greater insight into the human immune system. In addition, several failures of therapeutic approaches in humans that had compelling pre-clinical evidence suggests we may have an opportunity to better understand the relationship between the mice and man immunology. The aim of this workshop will be to compare and contrast our knowledge of rodent and human immunology with a view to applying research methods to achieve optimally translatability between species. Selected short talks will highlight research approaches and the moderators will facilitate discussion that focuses us on an end goal of testing novel immunomodulatory mechanisms in humans.
Speaker 4 of 5
Richard M. Siegel, NIAMS, National Institutes of Health, USA
A Systems Approach to Defining Contributions of TNF-Family Cytokines to Autoimmune Disease Susceptibility Reveals a Protective Role for TL1A/TNFSF15 in IBD

Monday, January 29 | 2:30PM - 4:30PM
Workshop 1: Translation from Mice to Man: Friendly Debate
Room: Ballroom 1-2
How can we optimize our ability to translate observations between rodent and human immunology? Advances in human immune-profiling, and genetics now provides us with greater insight into the human immune system. In addition, several failures of therapeutic approaches in humans that had compelling pre-clinical evidence suggests we may have an opportunity to better understand the relationship between the mice and man immunology. The aim of this workshop will be to compare and contrast our knowledge of rodent and human immunology with a view to applying research methods to achieve optimally translatability between species. Selected short talks will highlight research approaches and the moderators will facilitate discussion that focuses us on an end goal of testing novel immunomodulatory mechanisms in humans.
Speaker 3 of 5
Jeffrey Barrett, Genomics plc, UK
Using Human Genetics for Target Discovery in Inflammatory Bowel Disease

Monday, January 29 | 2:30PM - 4:30PM
Workshop 1: Translation from Mice to Man: Friendly Debate
Room: Ballroom 1-2
How can we optimize our ability to translate observations between rodent and human immunology? Advances in human immune-profiling, and genetics now provides us with greater insight into the human immune system. In addition, several failures of therapeutic approaches in humans that had compelling pre-clinical evidence suggests we may have an opportunity to better understand the relationship between the mice and man immunology. The aim of this workshop will be to compare and contrast our knowledge of rodent and human immunology with a view to applying research methods to achieve optimally translatability between species. Selected short talks will highlight research approaches and the moderators will facilitate discussion that focuses us on an end goal of testing novel immunomodulatory mechanisms in humans.
Speaker 2 of 5
* Mark M. Davis, Stanford University School of Medicine, USA

Monday, January 29 | 2:30PM - 4:30PM
Workshop 1: Translation from Mice to Man: Friendly Debate
Room: Ballroom 1-2
How can we optimize our ability to translate observations between rodent and human immunology? Advances in human immune-profiling, and genetics now provides us with greater insight into the human immune system. In addition, several failures of therapeutic approaches in humans that had compelling pre-clinical evidence suggests we may have an opportunity to better understand the relationship between the mice and man immunology. The aim of this workshop will be to compare and contrast our knowledge of rodent and human immunology with a view to applying research methods to achieve optimally translatability between species. Selected short talks will highlight research approaches and the moderators will facilitate discussion that focuses us on an end goal of testing novel immunomodulatory mechanisms in humans.
Speaker 1 of 5
* Michael Vincent, Pfizer Inc., USA

Monday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, January 29 | 5:00PM - 7:00PM
Genetics and Epigenetics Variation in Human Immune Traits
Room: Ballroom 1-2
Understanding natural genetic variability as a foundation for investigation for the immune system networks and pathways.
Speaker 3 of 5
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Transcriptional and Epigenetic Regulation in Cancer and Cancer Immunotherapy

Monday, January 29 | 5:00PM - 7:00PM
Genetics and Epigenetics Variation in Human Immune Traits
Room: Ballroom 1-2
Understanding natural genetic variability as a foundation for investigation for the immune system networks and pathways.
Speaker 2 of 5
Julian C. Knight, University of Oxford, UK
Genetic and Epigenetic Modulators of Monocyte Activation in Health and Disease

Monday, January 29 | 5:00PM - 7:00PM
Genetics and Epigenetics Variation in Human Immune Traits
Room: Ballroom 1-2
Understanding natural genetic variability as a foundation for investigation for the immune system networks and pathways.
Speaker 1 of 5
* Sally John, Biogen, USA

Monday, January 29 | 5:00PM - 7:00PM
Genetics and Epigenetics Variation in Human Immune Traits
Room: Ballroom 1-2
Understanding natural genetic variability as a foundation for investigation for the immune system networks and pathways.
Speaker 4 of 5
Nicole Soranzo, Wellcome Trust Sanger Institute, UK
Human Genetic Variation of Hematological Parameters

Monday, January 29 | 5:00PM - 7:00PM
Genetics and Epigenetics Variation in Human Immune Traits
Room: Ballroom 1-2
Understanding natural genetic variability as a foundation for investigation for the immune system networks and pathways.
Speaker 5 of 5
Dafni Glinos, Wellcome Trust Sanger Institute, UK
Short Talk: Genetic Effects on Transcriptional Variation of Human T Regulatory Cells

Monday, January 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 3
No registration fees are used to fund alcohol served at this function.

Monday, January 29 | 7:30PM - 10:00PM
Poster Session 1
Room: Ballroom 3


Tuesday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, January 30 | 8:00AM - 11:15AM
Advancing our Understanding of Immune Cell Repertoires
Room: Ballroom 1-2
Progress in understanding the natural variation in immune receptor repertoires and explore potential diagnostic and therapeutic applications.
Speaker 1 of 8
* Michael Vincent, Pfizer Inc., USA

Tuesday, January 30 | 8:00AM - 11:15AM
Advancing our Understanding of Immune Cell Repertoires
Room: Ballroom 1-2
Progress in understanding the natural variation in immune receptor repertoires and explore potential diagnostic and therapeutic applications.
Speaker 2 of 8
Aleksandra Walczak, École Normale Supérieure, France
Diversity of Immune Receptor Repertoires

Tuesday, January 30 | 8:00AM - 11:15AM
Advancing our Understanding of Immune Cell Repertoires
Room: Ballroom 1-2
Progress in understanding the natural variation in immune receptor repertoires and explore potential diagnostic and therapeutic applications.
Speaker 3 of 8
Mark M. Davis, Stanford University School of Medicine, USA
T-Cell Repertoires and How to Read Them

Tuesday, January 30 | 8:00AM - 11:15AM
Advancing our Understanding of Immune Cell Repertoires
Room: Ballroom 1-2
Progress in understanding the natural variation in immune receptor repertoires and explore potential diagnostic and therapeutic applications.

Coffee Break

Tuesday, January 30 | 8:00AM - 11:15AM
Advancing our Understanding of Immune Cell Repertoires
Room: Ballroom 1-2
Progress in understanding the natural variation in immune receptor repertoires and explore potential diagnostic and therapeutic applications.
Speaker 5 of 8
Harlan Robins, Adaptive Biotechnologies, USA
Reading the Cellular Adaptive Immune System to Diagnose Disease

Tuesday, January 30 | 8:00AM - 11:15AM
Advancing our Understanding of Immune Cell Repertoires
Room: Ballroom 1-2
Progress in understanding the natural variation in immune receptor repertoires and explore potential diagnostic and therapeutic applications.
Speaker 6 of 8
George Georgiou, University of Texas at Austin, USA
The Human Serological and BCR Antibody Repertoires in Cancer, Autoimmunity or following Vaccination

Tuesday, January 30 | 8:00AM - 11:15AM
Advancing our Understanding of Immune Cell Repertoires
Room: Ballroom 1-2
Progress in understanding the natural variation in immune receptor repertoires and explore potential diagnostic and therapeutic applications.
Speaker 7 of 8
Nathaniel D. Chu, Massachusetts Institute of Technology, USA
Short Talk: Longitudinal Immunosequencing in Healthy Individuals Reveals Persistent T Cell Receptors Rich in Public Receptors

Tuesday, January 30 | 8:00AM - 11:15AM
Advancing our Understanding of Immune Cell Repertoires
Room: Ballroom 1-2
Progress in understanding the natural variation in immune receptor repertoires and explore potential diagnostic and therapeutic applications.
Speaker 8 of 8
Scott Nicholas Furlan, Seattle Children's Research Institute, USA
Short Talk: Dissecting the Mechanics of T Cell Alloproliferation

Tuesday, January 30 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, January 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom 3


Tuesday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, January 30 | 5:00PM - 7:00PM
Integrative Analysis, Dynamic Networks and Systems Immunolog
y

Room: Ballroom 1-2
In this session we focus on different methodological approaches to build networks and models of systems.
Speaker 1 of 5
* Soumya Raychaudhuri, Brigham and Women's Hospital, Harvard Medical School, USA

Tuesday, January 30 | 5:00PM - 7:00PM
Integrative Analysis, Dynamic Networks and Systems Immunolog
y

Room: Ballroom 1-2
In this session we focus on different methodological approaches to build networks and models of systems.
Speaker 2 of 5
Kasper Lage, Massachusetts General Hospital, USA
Human Gene and Protein Networks Perturbed by Genetics to Identify Therapeutics

Tuesday, January 30 | 5:00PM - 7:00PM
Integrative Analysis, Dynamic Networks and Systems Immunolog
y

Room: Ballroom 1-2
In this session we focus on different methodological approaches to build networks and models of systems.
Speaker 3 of 5
Manolis Kellis, Massachusetts Institute of Technology, Broad Institute, USA
Talk Title to be Announced

Tuesday, January 30 | 5:00PM - 7:00PM
Integrative Analysis, Dynamic Networks and Systems Immunolog
y

Room: Ballroom 1-2
In this session we focus on different methodological approaches to build networks and models of systems.
Speaker 4 of 5
Shai S. Shen-Orr, Technion, Israel
Connect the Dots – An Integrative Cell-Centered View of Immunity

Tuesday, January 30 | 5:00PM - 7:00PM
Integrative Analysis, Dynamic Networks and Systems Immunolog
y

Room: Ballroom 1-2
In this session we focus on different methodological approaches to build networks and models of systems.
Speaker 5 of 5
Jiyang Yu, St. Jude Children's Research Hospital, USA
Short Talk: NetBID, a Novel Systems Biology Approach, Identifies Hippo Signaling as a “Hidden” Driver Selectively Programming CD8a+ Dendritic Cell Activity

Tuesday, January 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 3
No registration fees are used to fund alcohol served at this function.

Tuesday, January 30 | 7:30PM - 10:00PM
Poster Session 2
Room: Ballroom 3


Wednesday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, January 31 | 8:00AM - 11:15AM
Systems Immunology at the Tissue Level
Room: Ballroom 1-2

Speaker 1 of 8
* Nicole Soranzo, Wellcome Trust Sanger Institute, UK

Wednesday, January 31 | 8:00AM - 11:15AM
Systems Immunology at the Tissue Level
Room: Ballroom 1-2

Speaker 2 of 8
Betty Diamond, Feinstein Institute for Medical Research, USA
Deconstructing Lupus Nephritis through a Single Analysis of Immune Cells in the Kidney

Wednesday, January 31 | 8:00AM - 11:15AM
Systems Immunology at the Tissue Level
Room: Ballroom 1-2

Speaker 3 of 8
Soumya Raychaudhuri, Brigham and Women's Hospital, Harvard Medical School, USA
Single Cell Sequencing in Rheumatoid Synovial Tissue

Wednesday, January 31 | 8:00AM - 11:15AM
Systems Immunology at the Tissue Level
Room: Ballroom 1-2


Coffee Break

Wednesday, January 31 | 8:00AM - 11:15AM
Systems Immunology at the Tissue Level
Room: Ballroom 1-2

Speaker 5 of 8
Carolyn B. Coyne, University of Pittsburgh, USA
Immunology of the Human Placenta

Wednesday, January 31 | 8:00AM - 11:15AM
Systems Immunology at the Tissue Level
Room: Ballroom 1-2

Speaker 6 of 8
Elham Azizi, Memorial Sloan Kettering Cancer Center, USA
Computational Approaches to Understanding Cellular Heterogeneity in the Tumor-Immune Microenvironment

Wednesday, January 31 | 8:00AM - 11:15AM
Systems Immunology at the Tissue Level
Room: Ballroom 1-2

Speaker 7 of 8
Zoltan Maliga, Harvard Medical School, USA
Short Talk: Deep Immunophenotyping of Idiopathic and ICI-Induced Skin Disease with Cyclic Immunofluorescence Microscopy

Wednesday, January 31 | 8:00AM - 11:15AM
Systems Immunology at the Tissue Level
Room: Ballroom 1-2

Speaker 8 of 8
Michelle Miron, Columbia University, USA
Short Talk: Human Lymph Nodes Maintain Resident Memory T Cells with High Proliferative Capacity and Clonal Diversity

Wednesday, January 31 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, January 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom 3


Wednesday, January 31 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, January 31 | 5:00PM - 7:00PM
Human Immune Response to Infectious Disease
Room: Ballroom 1-2

Speaker 1 of 5
* Mark M. Davis, Stanford University School of Medicine, USA

Wednesday, January 31 | 5:00PM - 7:00PM
Human Immune Response to Infectious Disease
Room: Ballroom 1-2

Speaker 2 of 5
Bali Pulendran, Stanford University School of Medicine, USA
Microbiome and B Cell Responses

Wednesday, January 31 | 5:00PM - 7:00PM
Human Immune Response to Infectious Disease
Room: Ballroom 1-2

Speaker 3 of 5
Purvesh Khatri, Stanford University, USA
Adventures of a 'Data Parasite': Translational Medicine using Heterogeneous Public Data

Wednesday, January 31 | 5:00PM - 7:00PM
Human Immune Response to Infectious Disease
Room: Ballroom 1-2

Speaker 4 of 5
Máté Manczinger, MTA Szegedi Biológiai Kutatóközpont, Hungary
Short Talk: Pathogen Diversity Drives the Evolution of Promiscuous Peptide Binding of Human MHC-II Alleles

Wednesday, January 31 | 5:00PM - 7:00PM
Human Immune Response to Infectious Disease
Room: Ballroom 1-2

Speaker 5 of 5
Susanna S. Ng, QIMR Berghofer Medical Research Institute, Australia
Short Talk: Identifying Novel Immune Checkpoint Molecules that can be Targeted to Improve CD4+ T Helper Cell Function during Chronic Infection

Wednesday, January 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 3
No registration fees are used to fund alcohol served at this function.

Wednesday, January 31 | 7:30PM - 10:00PM
Poster Session 3
Room: Ballroom 3


Thursday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, February 01 | 8:00AM - 11:30AM
Immuno-Oncology from Basic Science to Clinical Practice
Room: Ballroom 1-2
The next generation of oncology drugs relies upon a deeper knowledge of the interaction between host immune system and tumour biology.
Speaker 1 of 9
* Kasper Lage, Massachusetts General Hospital, USA

Thursday, February 01 | 8:00AM - 11:30AM
Immuno-Oncology from Basic Science to Clinical Practice
Room: Ballroom 1-2
The next generation of oncology drugs relies upon a deeper knowledge of the interaction between host immune system and tumour biology.
Speaker 2 of 9
Shannon J. Turley, Genentech, Inc., USA
Leukocyte Function and Positioning in Diverse Stromal Niches

Thursday, February 01 | 8:00AM - 11:30AM
Immuno-Oncology from Basic Science to Clinical Practice
Room: Ballroom 1-2
The next generation of oncology drugs relies upon a deeper knowledge of the interaction between host immune system and tumour biology.
Speaker 3 of 9
Alexandra Snyder, Merck, USA
T Cell Receptor Sequencing (TCR) in Immuno-Oncology: Systemic, Intratumoral and Antigen-Specific Immunity

Thursday, February 01 | 8:00AM - 11:30AM
Immuno-Oncology from Basic Science to Clinical Practice
Room: Ballroom 1-2
The next generation of oncology drugs relies upon a deeper knowledge of the interaction between host immune system and tumour biology.

Coffee Break

Thursday, February 01 | 8:00AM - 11:30AM
Immuno-Oncology from Basic Science to Clinical Practice
Room: Ballroom 1-2
The next generation of oncology drugs relies upon a deeper knowledge of the interaction between host immune system and tumour biology.
Speaker 5 of 9
Cassian Yee, University of Texas MD Anderson Cancer Center, USA
Terminators: No Fate but What You Make

Thursday, February 01 | 8:00AM - 11:30AM
Immuno-Oncology from Basic Science to Clinical Practice
Room: Ballroom 1-2
The next generation of oncology drugs relies upon a deeper knowledge of the interaction between host immune system and tumour biology.
Speaker 6 of 9
Wendy Broom, Genocea Biosciences, USA
Neoantigen Identification using ATLAS Across Multiple Tumor Types Highlights Limitations of Prediction Algorithms

Thursday, February 01 | 8:00AM - 11:30AM
Immuno-Oncology from Basic Science to Clinical Practice
Room: Ballroom 1-2
The next generation of oncology drugs relies upon a deeper knowledge of the interaction between host immune system and tumour biology.
Speaker 7 of 9
Pauline L. Gonnord, INSERM UMR1043, France
Short Talk: High-Dimensional Immunophenotyping of Chronic Lymphocytic Leukemia (CLL) Patients Reveals Remodeling of the CD8+ T Cell Compartment by Tumor Progression and Predicts Need for Therapy

Thursday, February 01 | 8:00AM - 11:30AM
Immuno-Oncology from Basic Science to Clinical Practice
Room: Ballroom 1-2
The next generation of oncology drugs relies upon a deeper knowledge of the interaction between host immune system and tumour biology.
Speaker 8 of 9
Daniel Wells, Parker Institute for Cancer Immunotherapy, USA
Short Talk: Genetic Mechanisms of Immune Evasion in Colorectal Cancer

Thursday, February 01 | 8:00AM - 11:30AM
Immuno-Oncology from Basic Science to Clinical Practice
Room: Ballroom 1-2
The next generation of oncology drugs relies upon a deeper knowledge of the interaction between host immune system and tumour biology.
Speaker 9 of 9
Mazlina Ismail, University College London, UK
Short Talk: Characterising the T Cell Receptor Repertoire of Patients with Non-small-cell Lung Cancer (NSCLC) within the Lung TRACERx Study

Thursday, February 01 | 11:30AM - 5:00PM
On Own for Lunch


Thursday, February 01 | 2:30PM - 4:30PM
Workshop 2: CyTOF Change to Human Immunoprofiling
Room: Ballroom 1-2

Speaker 1 of 8
* Soumya Raychaudhuri, Brigham and Women's Hospital, Harvard Medical School, USA

Thursday, February 01 | 2:30PM - 4:30PM
Workshop 2: CyTOF Change to Human Immunoprofiling
Room: Ballroom 1-2

Speaker 2 of 8
Petter Brodin, Karolinska Institutet, Sweden
Convergence of Immune Systems in Diverse Newborn Children during the First Months of Life

Thursday, February 01 | 2:30PM - 4:30PM
Workshop 2: CyTOF Change to Human Immunoprofiling
Room: Ballroom 1-2

Speaker 3 of 8
Jean-Louis Palgen, Commissariat Energie Atomique (CEA), France
Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response

Thursday, February 01 | 2:30PM - 4:30PM
Workshop 2: CyTOF Change to Human Immunoprofiling
Room: Ballroom 1-2

Speaker 4 of 8
Luis Miguel Franco, National Institutes of Health, USA
Immune Regulation by Glucocorticoids Can Be Linked to Cell-Lineage-Specific Transcriptional Responses

Thursday, February 01 | 2:30PM - 4:30PM
Workshop 2: CyTOF Change to Human Immunoprofiling
Room: Ballroom 1-2

Speaker 5 of 8
Oisin Huhn, University of Cambridge, UK
Characterizing the Architecture of the Decidual Natural Killer Cell Niche using Time of Flight Mass Cytometry

Thursday, February 01 | 2:30PM - 4:30PM
Workshop 2: CyTOF Change to Human Immunoprofiling
Room: Ballroom 1-2

Speaker 6 of 8
Ainhoa Perez-Diez, NIAID, National Institutes of Health, USA
Antibody Profiling Identifies a Strong and Widespread Auto-Immune Response in Idiopathic CD4 Lymphopenic Patients

Thursday, February 01 | 2:30PM - 4:30PM
Workshop 2: CyTOF Change to Human Immunoprofiling
Room: Ballroom 1-2

Speaker 7 of 8
Arnon Arazi, Broad Institute, USA
Beyond Clustering: Using scRNA-seq Data to Generate Quantitative, Testable Models of Human Disease

Thursday, February 01 | 2:30PM - 4:30PM
Workshop 2: CyTOF Change to Human Immunoprofiling
Room: Ballroom 1-2

Speaker 8 of 8
Ning Jenny Jiang, University of Texas at Austin, USA
High-Throughput Detection of T Cell Antigen Reactivity at Single T Cell Level using de novo Generated DNA-Linked MHC Tetramers

Thursday, February 01 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, February 01 | 5:00PM - 7:00PM
Clinical Immunoprofiling and Patient Stratification
Room: Ballroom 1-2

Speaker 1 of 5
* David M. Sansom, University College London Medical School, UK

Thursday, February 01 | 5:00PM - 7:00PM
Clinical Immunoprofiling and Patient Stratification
Room: Ballroom 1-2

Speaker 2 of 5
Holden T. Maecker, Stanford School of Medicine, USA
Comprehensive Immune Profiling and Functional Analysis of Human Aging / Response to Therapy

Thursday, February 01 | 5:00PM - 7:00PM
Clinical Immunoprofiling and Patient Stratification
Room: Ballroom 1-2

Speaker 3 of 5
Sally John, Biogen, USA
A Network Approach to Understanding the Role of the Immune System in Neurodegenerative Disease

Thursday, February 01 | 5:00PM - 7:00PM
Clinical Immunoprofiling and Patient Stratification
Room: Ballroom 1-2

Speaker 4 of 5
Sathya Baarathi Shanthi Ravichandran, Indian Institute of Science, India
Short Talk: Identification of a Robust Blood-Based Biomarker Signature for Chronic Systemic Inflammation through a Meta-Analysis of Disease Networks

Thursday, February 01 | 5:00PM - 7:00PM
Clinical Immunoprofiling and Patient Stratification
Room: Ballroom 1-2

Speaker 5 of 5
Maria Gutierrez-Arcelus, Harvard Medical School, USA
Short Talk: Cis Regulatory Variation Determines Time Dependent Allelic Expression of HLA-DQB1 during T Cell Activation

Thursday, February 01 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Ballroom 1-2


Thursday, February 01 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Ballroom 2-3
No registration fees are used to fund alcohol served at this function.

Thursday, February 01 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2-3
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, February 01 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 2-3


Friday, February 02 | 10:24AM - 10:24AM
Departure


*Session Chair.