Web Desc
Emerging Cellular Therapies: T Cells and Beyond
joint with Lymphocytes and their Roles in Cancer
Organizer(s): Carl H. June, Marcela V. Maus and Bruce R. Blazar
Date: February 11 - 15, 2018
Location: Keystone Resort, Keystone, CO, USA
Sponsored by BioLegend, Inc., Editas Medicine, Gilead Sciences, Inc., Juno Therapeutics, Regeneron Pharmaceuticals, Inc., Sangamo Therapeutics, Inc. and Takeda Pharmaceutical Company Limited. This activity was supported by an educational grant from Celgene Corporation.
Summary of Meeting:
A new community of researchers is emerging that focuses on studying and developing cellular therapies against cancer and chronic infections. The field is advancing rapidly due to our deepening understanding of cell biology. New technologies permit efficient cell culture, gene transfer and genetic editing, enabling autologous and allogeneic cell therapy. With rapid development of CAR T cells, breakthrough FDA approval status, and fast-tracking clinical trials, competition is fierce in the biotechnology and pharmaceutical industries. Cell therapies with stem cells and T cells are in advanced clinical development that will enable widespread use for cancer and chronic infections such as HIV. Infusions of regulatory T cells (Tregs) have the potential to benefit patients with autoimmunity and transplantation. A goal of this conference is to bring together basic and translational scientists from these fields to identify current opportunities and challenges in cell therapies. Another goal is to bridge the fields of effector T cell and Treg cell therapies. The interdisciplinary features of this meeting should facilitate new collaborations and interactions between investigators who would not normally meet.
Scholarship Deadline: October 11 2017
Discounted Abstract Deadline: October 11 2017
Abstract Deadline: November 9 2017
Discounted Registration Deadline: December 13 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
BioLegend, Inc.This activity was supported by an educational grant from Celgene CorporationEditas MedicineGilead Sciences, Inc.Juno TherapeuticsRegeneron Pharmaceuticals, Inc.Sangamo Therapeutics, Inc.Takeda Pharmaceutical Company Limited
We gratefully acknowledge additional support from these exhibitors at this conference:
Xcell Biosciences
We gratefully acknowledge additional support for this conference from:
AgilentBellicum PharmaceuticalsBio-Techne
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA224778-01
Funding for this conference was made possible (in part) by 1 R13 CA224778-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 11 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, February 11 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Monday, February 12 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays/Longs Peak

Speaker 1 of 4
* Bruce R. Blazar, University of Minnesota, USA

Monday, February 12 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays/Longs Peak

Speaker 2 of 4
* Carl H. June, University of Pennsylvania, USA

Monday, February 12 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays/Longs Peak

Speaker 3 of 4
* Marcela V. Maus, Harvard Medical School, USA

Monday, February 12 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays/Longs Peak

Speaker 4 of 4
Ton N. Schumacher, Netherlands Cancer Institute, Netherlands
T Cell Recognition in Human Cancer

Monday, February 12 | 9:00AM - 11:30AM
CAR/TCR Preclinical
Room: Grays/Longs Peak

Speaker 1 of 7
* Carl H. June, University of Pennsylvania, USA

Monday, February 12 | 9:00AM - 11:30AM
CAR/TCR Preclinical
Room: Grays/Longs Peak

Speaker 2 of 7
Philip D. Greenberg, University of Washington, USA
Making TCR-Modified T Cells Effective for Leukemia and Solid Tumors

Monday, February 12 | 9:00AM - 11:30AM
CAR/TCR Preclinical
Room: Grays/Longs Peak


Coffee Break

Monday, February 12 | 9:00AM - 11:30AM
CAR/TCR Preclinical
Room: Grays/Longs Peak

Speaker 4 of 7
Crystal L. Mackall, Stanford University, USA
What’s Next? Preclinical Studies Paving the Way for Future CAR T Cell Trials

Monday, February 12 | 9:00AM - 11:30AM
CAR/TCR Preclinical
Room: Grays/Longs Peak

Speaker 5 of 7
Stanley R. Riddell, Fred Hutchinson Cancer Research Center, University of Washington, USA
Strategies to Improve the Efficacy of CAR T Cells in Solid Tumors

Monday, February 12 | 9:00AM - 11:30AM
CAR/TCR Preclinical
Room: Grays/Longs Peak

Speaker 6 of 7
Reno Debets, Erasmus MC Cancer Institute, Netherlands
Short Talk: T Cell Receptors Equipped with ICOS Enhance T Cell Persistence and Mediate Sustainable Anti-Tumor Responses upon Adoptive T Cell Therapy

Monday, February 12 | 9:00AM - 11:30AM
CAR/TCR Preclinical
Room: Grays/Longs Peak

Speaker 7 of 7
James Scott-Browne, La Jolla Institute, USA
Short Talk: Transcriptional Control of CAR-T Cell Function in Solid Tumors

Monday, February 12 | 9:00AM - 11:15AM
Understanding Lymphocytic Malignancy: Leukemia and Lymphoma
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 1 of 6
* Adolfo Ferrando, Columbia University, USA


Monday, February 12 | 9:00AM - 11:15AM
Understanding Lymphocytic Malignancy: Leukemia and Lymphoma
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 2 of 6
Louis M. Staudt, NCI, National Institutes of Health, USA
The MYD88-TLR9-B Cell Receptor Complex as a Target for Therapy in Aggressive Lymphomas


Monday, February 12 | 9:00AM - 11:15AM
Understanding Lymphocytic Malignancy: Leukemia and Lymphoma
This session is from Lymphocytes and Cancer
Room: Quandary Peak


Coffee Break


Monday, February 12 | 9:00AM - 11:15AM
Understanding Lymphocytic Malignancy: Leukemia and Lymphoma
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 4 of 6
Charles G. Mullighan, St. Jude Children's Research Hospital, USA
The Role of CREBBP Mutations in Drug Resistance in Acute Lymphoblastic Leukemia


Monday, February 12 | 9:00AM - 11:15AM
Understanding Lymphocytic Malignancy: Leukemia and Lymphoma
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 5 of 6
Katia Georgopoulos, Massachusetts General Hospital, USA
Super-Enhancer Circuits in B Cell Development and Transformation


Monday, February 12 | 9:00AM - 11:15AM
Understanding Lymphocytic Malignancy: Leukemia and Lymphoma
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 6 of 6
Anastasia N. Tikhonova, New York University Medical School, USA
Short Talk: Single-Cell Dynamics of Bone Marrow Microenvironment


Monday, February 12 | 11:30AM - 5:00PM
On Own for Lunch


Monday, February 12 | 11:30AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Monday, February 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Perspectives from Industry
Room: Grays/Longs Peak

Speaker 1 of 9
* Charles Sentman, Geisel School of Medicine at Dartmouth, USA

Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Perspectives from Industry
Room: Grays/Longs Peak

Speaker 2 of 9
Amy Gilbert, Cell Design Labs, USA
Development of a SynNotch Combinatorial “and” Gate CAR T for Solid Tumors

Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Perspectives from Industry
Room: Grays/Longs Peak

Speaker 3 of 9
Ian R. Hardy, TCR2 Therapeutics, USA
Improving CAR-T Cell Function with Small Molecule Treatment during Production

Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Perspectives from Industry
Room: Grays/Longs Peak

Speaker 4 of 9
Kelan Hlavaty, SQZ Biotech, USA
Engineering T Cells Using a Microfluidic Intracellular Delivery Method for Cell Therapy

Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Perspectives from Industry
Room: Grays/Longs Peak

Speaker 5 of 9
Robert J. Hofmeister, TCR2 Therapeutics, USA
A Novel T Cell Therapy Engaging the Complete T Cell Receptor

Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Perspectives from Industry
Room: Grays/Longs Peak

Speaker 6 of 9
Lenka V. Hurton, ZIOPHARM Oncology, USA
Rapid Production of T Cells Co-expressing CAR and Membrane-bound IL-15 Potentiates Antitumor Activity and Promotes in vivo Memory

Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Perspectives from Industry
Room: Grays/Longs Peak

Speaker 7 of 9
Sumiti Jain, Sangamo Therapeutics, USA
Precise T Cell Engineering using Enhanced Zinc-finger Nucleases (ZFNs) for Highly Specific and Efficient Dual Knock-Out of Endogenous T-Cell Receptor and HLA-Class I with Site-Specific Insertion of a CD19-CAR: Implications for Allogeneic T Cell Therapy

Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Perspectives from Industry
Room: Grays/Longs Peak

Speaker 8 of 9
Inez Johanna, University Medical Center Utrecht, Netherlands
Towards the Next Generation CAR T Cells with TEGs: In vivo Efficacy – Toxicity Profile in Xenografts of Primary Human AML Disease and Healthy Bone Marrow

Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Perspectives from Industry
Room: Grays/Longs Peak

Speaker 9 of 9
Levi Rupp, Cell Design Labs, USA
THROTTLETM CARs: A Novel Platform for Enhanced Safety and Efficacy via Titratable Control of CAR-T Activity using an FDA-Approved Small Molecule

Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Understanding and Targeting Lymphocytes in Cance
r
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 1 of 9
* Iannis Aifantis, New York University School of Medicine, USA


Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Understanding and Targeting Lymphocytes in Cance
r
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 2 of 9
Eirini Giannakopoulou, Radiumhospitalet, Norway
T Cell Receptor-Mediated Targeting of Recurrent Neoantigens in Acute Myeloid Leukemia


Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Understanding and Targeting Lymphocytes in Cance
r
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 3 of 9
Wenting Zheng, St. Jude Children Research Hospital, USA
PI3K Orchestration of the in vivo Persistence of Chimeric Antigen Receptor-Modified T Cells


Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Understanding and Targeting Lymphocytes in Cance
r
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 4 of 9
Elena Montauti, Northwestern University, USA
USP22 Maintains Regulatory T Cells by Stabilizing Foxp3 Protein Level and Impairs Anti-Tumor Immune Response


Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Understanding and Targeting Lymphocytes in Cance
r
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 5 of 9
Jeffrey Ward, Washington University School of Medicine, USA
Remodeling of Myeloid as well as Lymphoid Compartments following Checkpoint Blockade Immunotherapy


Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Understanding and Targeting Lymphocytes in Cance
r
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 6 of 9
Soki Kashima, Kyoto University, Japan
WT1-Specific Cytotoxic T Lymphocytes Regenerated from T Cell-Derived iPS Cells Exert Therapeutic Effect in Xenograft Model of Renal Cell Carcinoma


Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Understanding and Targeting Lymphocytes in Cance
r
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 7 of 9
Chris Nicolai, University of California, Berkeley, USA
Mechanisms of MHC-Deficient Tumor Clearance using STING Agonists


Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Understanding and Targeting Lymphocytes in Cance
r
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 8 of 9
Julie Rytlewski, Bristol-Myers Squibb, USA
History of Prior Immunotherapy Changes Relationship between Tumor Mutations and TIL Repertoire


Monday, February 12 | 2:30PM - 4:30PM
Workshop 1: Understanding and Targeting Lymphocytes in Cance
r
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 9 of 9
Angela Vasaturo, INSERM UMRS 1138, France
Unraveling the Immune Contexture of Pre-Invasive Lesions of the Lung by Multispectral Imaging


Monday, February 12 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 12 | 5:00PM - 7:00PM
Synthetic Biology
Room: Grays/Longs Peak

Speaker 1 of 5
* Crystal L. Mackall, Stanford University, USA

Monday, February 12 | 5:00PM - 7:00PM
Synthetic Biology
Room: Grays/Longs Peak

Speaker 2 of 5
Darrell J. Irvine, Massachusetts Institute of Technology, USA
Chemically Engineering T Cell Therapies

Monday, February 12 | 5:00PM - 7:00PM
Synthetic Biology
Room: Grays/Longs Peak

Speaker 3 of 5
Wendell A. Lim, University of California, San Francisco, USA
Optimizing Synthetic Biology Tools for T Cell Therapies

Monday, February 12 | 5:00PM - 7:00PM
Synthetic Biology
Room: Grays/Longs Peak

Speaker 4 of 5
Travis Young, California Institute for Biomedical Research, USA
Controllable CAR-T Cell Therapy

Monday, February 12 | 5:00PM - 7:00PM
Synthetic Biology
Room: Grays/Longs Peak

Speaker 5 of 5
Patrick Ho, University of California, Los Angeles, USA
Short Talk: COVERT T Cells: Engineering T Cells to Interrogate Intracellular Antigens

Monday, February 12 | 5:00PM - 7:00PM
Therapeutic Targeting of Lymphocytic Malignancy
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 1 of 5
* Charles G. Mullighan, St. Jude Children's Research Hospital, USA


Monday, February 12 | 5:00PM - 7:00PM
Therapeutic Targeting of Lymphocytic Malignancy
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 2 of 5
Adolfo Ferrando, Columbia University, USA
Epigenetic Mechanisms in T-Cell Acute Lymphoblastic Leukemia


Monday, February 12 | 5:00PM - 7:00PM
Therapeutic Targeting of Lymphocytic Malignancy
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 3 of 5
Iannis Aifantis, New York University School of Medicine, USA
Targeting Stress Responses in Acute Lymphocytic Leukemia


Monday, February 12 | 5:00PM - 7:00PM
Therapeutic Targeting of Lymphocytic Malignancy
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 4 of 5
Andrei Thomas-Tikhonenko, Children's Hospital of Philadelphia and University of Pennsylvania, USA
Escape Hatches for Immunotherapies Targeting B-Cell Differentiation Antigens


Monday, February 12 | 5:00PM - 7:00PM
Therapeutic Targeting of Lymphocytic Malignancy
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 5 of 5
Jacques G. M. Ghysdael, Institut Curie, France
Short Talk: Triggering the Tcr Developmental Checkpoint Activates a Therapeutically Targetable Anti-Leukemic Pathway in T-Cell Acute Lymphoblastic Leukemia


Monday, February 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, February 12 | 7:30PM - 10:00PM
Poster Session 1
Room: Colorado Rockies Ballroom


Tuesday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Tuesday, February 13 | 8:00AM - 11:00AM
Engineered T Cells for Viruses
Room: Grays/Longs Peak

Speaker 1 of 7
* Philip D. Greenberg, University of Washington, USA

Tuesday, February 13 | 8:00AM - 11:00AM
Engineered T Cells for Viruses
Room: Grays/Longs Peak

Speaker 2 of 7
Catherine M. Bollard, Children’s National Health System, USA
Developing HIV-Specific T Cell Therapies: Lessons from EBV

Tuesday, February 13 | 8:00AM - 11:00AM
Engineered T Cells for Viruses
Room: Grays/Longs Peak

Speaker 3 of 7
Paula M. Cannon, University of Southern California, Keck School of Medicine, USA
Shutting the Door on HIV by Engineering Hematopoietic Stem Cells

Tuesday, February 13 | 8:00AM - 11:00AM
Engineered T Cells for Viruses
Room: Grays/Longs Peak


Coffee Break

Tuesday, February 13 | 8:00AM - 11:00AM
Engineered T Cells for Viruses
Room: Grays/Longs Peak

Speaker 5 of 7
James L. Riley, University of Pennsylvania, USA
Engineering T Cells to Functionally Cure HIV-1 Infection

Tuesday, February 13 | 8:00AM - 11:00AM
Engineered T Cells for Viruses
Room: Grays/Longs Peak

Speaker 6 of 7
Scott G. Kitchen, University of California, Los Angeles AIDS Institute, USA
Engineering Antiviral CAR T Cell Immunity through Hematopoietic Stem/Progenitor Cells

Tuesday, February 13 | 8:00AM - 11:00AM
Engineered T Cells for Viruses
Room: Grays/Longs Peak

Speaker 7 of 7
Alok Vishnu Joglekar, California Institute of Technology, USA
Short Talk: Hematopoietic Stem/Progenitor Cells Engineered with T Cell Receptors for Immunotherapy for HIV Infection

Tuesday, February 13 | 8:00AM - 11:00AM
Cellular Therapies in Blood Malignancies and Beyond
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 1 of 7
* Ugur Sahin, BioNTech AG, Germany


Tuesday, February 13 | 8:00AM - 11:00AM
Cellular Therapies in Blood Malignancies and Beyond
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 2 of 7
Carl H. June, University of Pennsylvania, USA
CAR T Cells and their Therapeutic Promise in the Treatment of Leukemia


Tuesday, February 13 | 8:00AM - 11:00AM
Cellular Therapies in Blood Malignancies and Beyond
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 3 of 7
Crystal L. Mackall, Stanford University, USA
CAR Vulnerabilities: Emerging Insights from Clinical Trials


Tuesday, February 13 | 8:00AM - 11:00AM
Cellular Therapies in Blood Malignancies and Beyond
This session is from Lymphocytes and Cancer
Room: Quandary Peak


Coffee Break


Tuesday, February 13 | 8:00AM - 11:00AM
Cellular Therapies in Blood Malignancies and Beyond
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 5 of 7
Chiara Bonini, Ospedale San Raffaele, Italy
Gene Editing of Memory Stem T Cells for Cancer Immunotherapy


Tuesday, February 13 | 8:00AM - 11:00AM
Cellular Therapies in Blood Malignancies and Beyond
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 6 of 7
Justin Eyquem, University of California, San Francisco, USA
Precision T Cell Engineering to Advance Adoptive T Cell Therapies


Tuesday, February 13 | 8:00AM - 11:00AM
Cellular Therapies in Blood Malignancies and Beyond
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 7 of 7
Charlotte Mousset, Radboudumc, Netherlands
Short Talk: Superior Multi-Functionality and Glycolytic Function of Tumor-Reactive CD8+ TSCM-Like T Cells by ex vivo Akt-Inhibition


Tuesday, February 13 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, February 13 | 11:00AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Tuesday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Tuesday, February 13 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 13 | 5:00PM - 7:00PM
CAR/TCR in the Clinic for Cancer
Room: Grays/Longs Peak

Speaker 1 of 5
* Jeffrey S. Miller, University of Minnesota, USA

Tuesday, February 13 | 5:00PM - 7:00PM
CAR/TCR in the Clinic for Cancer
Room: Grays/Longs Peak

Speaker 2 of 5
Stephen J. Forman, City of Hope, USA
CAR T Cells for Treatment of Central Nervous System (CNS) Malignancy

Tuesday, February 13 | 5:00PM - 7:00PM
CAR/TCR in the Clinic for Cancer
Room: Grays/Longs Peak

Speaker 3 of 5
Marcela V. Maus, Harvard Medical School, USA
CAR T Cells Multiple Myeloma and Glioblastoma

Tuesday, February 13 | 5:00PM - 7:00PM
CAR/TCR in the Clinic for Cancer
Room: Grays/Longs Peak

Speaker 4 of 5
Saar I. Gill, University of Pennsylvania, USA
CAR T Cells for Acute Myelogenous Leukemia

Tuesday, February 13 | 5:00PM - 7:00PM
CAR/TCR in the Clinic for Cancer
Room: Grays/Longs Peak

Speaker 5 of 5
Jenessa Barbara Smith, Poseida Therapeutics, USA
Short Talk: PSMA-Specific CAR T-Stem Cell Memory Therapy Eliminates Solid Tumor in Prostate Cancer Model

Tuesday, February 13 | 5:00PM - 7:00PM
Lymphocytes as Elements of the Tumor Microenvironment
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 1 of 5
* Katia Georgopoulos, Massachusetts General Hospital, USA


Tuesday, February 13 | 5:00PM - 7:00PM
Lymphocytes as Elements of the Tumor Microenvironment
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 2 of 5
David H. Raulet, University of California, Berkeley, USA
Natural Killer Cell Activation and Inhibition: Potential for Cancer Therapy


Tuesday, February 13 | 5:00PM - 7:00PM
Lymphocytes as Elements of the Tumor Microenvironment
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 3 of 5
Michael Khodadoust, Stanford University, USA
T Cell Recognition of Lymphoma Immunoglobulin


Tuesday, February 13 | 5:00PM - 7:00PM
Lymphocytes as Elements of the Tumor Microenvironment
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 4 of 5
Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Visualization of the Switch from Immune Control to Immune Escape


Tuesday, February 13 | 5:00PM - 7:00PM
Lymphocytes as Elements of the Tumor Microenvironment
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 5 of 5
Annelise Snyder, University of Washington, USA
Short Talk: Anti-tumor Effects of Inflammatory Necroptosis Within the Tumor Microenvironment


Tuesday, February 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, February 13 | 7:30PM - 10:00PM
Poster Session 2
Room: Colorado Rockies Ballroom


Wednesday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Wednesday, February 14 | 8:00AM - 11:15AM
Tregs as Cellular Therapeutics
Room: Grays/Longs Peak

Speaker 1 of 8
* James L. Riley, University of Pennsylvania, USA

Wednesday, February 14 | 8:00AM - 11:15AM
Tregs as Cellular Therapeutics
Room: Grays/Longs Peak

Speaker 2 of 8
Bruce R. Blazar, University of Minnesota, USA
Vimentin Restrains Regulatory T-cell Suppression of Graft-versus-Host Disease

Wednesday, February 14 | 8:00AM - 11:15AM
Tregs as Cellular Therapeutics
Room: Grays/Longs Peak

Speaker 3 of 8
Jeffrey A. Bluestone, University of California, San Francisco, USA
Manipulating Tregs to Control Tolerance in Autoimmunity and Cancer

Wednesday, February 14 | 8:00AM - 11:15AM
Tregs as Cellular Therapeutics
Room: Grays/Longs Peak


Coffee Break

Wednesday, February 14 | 8:00AM - 11:15AM
Tregs as Cellular Therapeutics
Room: Grays/Longs Peak

Speaker 5 of 8
Megan K. Levings, University of British Columbia, Canada
HLA-A2 Directed CAR Tregs

Wednesday, February 14 | 8:00AM - 11:15AM
Tregs as Cellular Therapeutics
Room: Grays/Longs Peak

Speaker 6 of 8
David Klatzmann, Sorbonne University Medical School, France
IL-2 for Treg-Based Immunotherapies: In (and Out)

Wednesday, February 14 | 8:00AM - 11:15AM
Tregs as Cellular Therapeutics
Room: Grays/Longs Peak

Speaker 7 of 8
Angela C. Boroughs, Massachusetts General Hospital/Harvard University, USA
Short Talk: 4-1BB Co-Stimulation Inhibits CAR Treg Suppressive Function

Wednesday, February 14 | 8:00AM - 11:15AM
Tregs as Cellular Therapeutics
Room: Grays/Longs Peak

Speaker 8 of 8
Elmar Jaeckel, Hannover Medical School, Germany
Short Talk: Operational Tolerance in Allotransplantation by Use of Regulatory T Cells with a MHC-Specific Chimeric Antigen Receptor

Wednesday, February 14 | 8:00AM - 11:00AM
Emerging Technologies: Visualization and Dissection of the T
umor Microenvironment
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 1 of 6
* Mikala Egeblad, Cold Spring Harbor Laboratory, USA


Wednesday, February 14 | 8:00AM - 11:00AM
Emerging Technologies: Visualization and Dissection of the T
umor Microenvironment
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 2 of 6
Dana Pe'er, Memorial Sloan Kettering Cancer Center, USA
A Single Cell Approach to Understanding the Tumor Microenvironment


Wednesday, February 14 | 8:00AM - 11:00AM
Emerging Technologies: Visualization and Dissection of the T
umor Microenvironment
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 3 of 6
Matthew F. Krummel, University of California, San Francisco, USA
Imaging a World beyond Checkpoints: Innate Partners for Lymphocytes in Cancer


Wednesday, February 14 | 8:00AM - 11:00AM
Emerging Technologies: Visualization and Dissection of the T
umor Microenvironment
This session is from Lymphocytes and Cancer

Room: Quandary Peak


Coffee Break


Wednesday, February 14 | 8:00AM - 11:00AM
Emerging Technologies: Visualization and Dissection of the T
umor Microenvironment
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 5 of 6
Jerome Galon, INSERM UMRS1138, Cordeliers Research Center, France
Immunoscore as a Stronger Predictor of Patient Survival in Colorectal Cancer


Wednesday, February 14 | 8:00AM - 11:00AM
Emerging Technologies: Visualization and Dissection of the T
umor Microenvironment
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 6 of 6
Michael Goldberg, Dana-Farber Cancer Institute, USA
Enhancing Cancer Immunotherapy through Immuno-engineering


Wednesday, February 14 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, February 14 | 11:15AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Wednesday, February 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Wednesday, February 14 | 2:30PM - 4:30PM
Workshop 2: Cell Engineering
Room: Grays/Longs Peak

Speaker 1 of 9
* Martin Pule, University College London, UK

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop 2: Cell Engineering
Room: Grays/Longs Peak

Speaker 2 of 9
Zinaida Good, Stanford University, USA
Guiding T-Lymphocyte Differentiation in Cancer Immunotherapy Applications

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop 2: Cell Engineering
Room: Grays/Longs Peak

Speaker 3 of 9
Rachel C. Lynn, Lyell Immunopharma, USA
Disrupting the Balance: Engineering AP1 to Overcome CAR T Cell Exhaustion

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop 2: Cell Engineering
Room: Grays/Longs Peak

Speaker 4 of 9
Shannon K. Oda, Fred Hutchinson Cancer Research Center, USA
Cheating Death: A Fas-4-1BB Immunomodulatory Fusion Protein Obviates a Death Signal to Enhance T Cell Function and Adoptive Therapy Targeting Leukemia and Solid Tumors

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop 2: Cell Engineering
Room: Grays/Longs Peak

Speaker 5 of 9
William Lemieux, University of Montréal, Canada
Efficient Transduction of Nk Cells Method Resulting in a Robust and Sustained Transgene Expression for Immunotherapy

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop 2: Cell Engineering
Room: Grays/Longs Peak

Speaker 6 of 9
Masataka Suzuki, Baylor College of Medicine, USA
Adenovirotherapy Delivering Cytokine and Checkpoint Inhibitor Augments Chimeric Antigen Receptor T-Cell against Metastatic Head and Neck Cancer

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop 2: Cell Engineering
Room: Grays/Longs Peak

Speaker 7 of 9
Tori Yamamoto, NCI, University of Pennsylvania, USA
Cell Intrinsic Fas Signaling Inhibition to Improve Therapeutic Efficacy of T Cells

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop 2: Cell Engineering
Room: Grays/Longs Peak

Speaker 8 of 9
Nicholas F. Kuhn, Memorial Sloan Kettering Cancer Center, USA
Design of a Systemic Antitumor Response with CD40L-modified CAR T Cells

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop 2: Cell Engineering
Room: Grays/Longs Peak

Speaker 9 of 9
Joy (Yushu) Xie, Massachusetts Institute of Technology, USA
Engineering Single Domain Antibody-Based Chimeric Antigen Receptor T Cells for Treatment of Solid Tumors

Wednesday, February 14 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 14 | 5:00PM - 7:00PM
Beyond T Cells: HSC, T Progenitor and IPSCs I
Room: Grays/Longs Peak

Speaker 1 of 4
* Juan Carlos Zúñiga-Pflücker, Sunnybrook Research Institute, Canada

Wednesday, February 14 | 5:00PM - 7:00PM
Beyond T Cells: HSC, T Progenitor and IPSCs I
Room: Grays/Longs Peak

Speaker 2 of 4
Martin Pule, University College London, UK
New Designs in Synthetic T Cells

Wednesday, February 14 | 5:00PM - 7:00PM
Beyond T Cells: HSC, T Progenitor and IPSCs I
Room: Grays/Longs Peak

Speaker 3 of 4
Jeffrey S. Miller, University of Minnesota, USA
Novel Ways to Activate and Target NK Cells to Treat Cancer


Wednesday, February 14 | 5:00PM - 7:00PM
Beyond T Cells: HSC, T Progenitor and IPSCs I
Room: Grays/Longs Peak

Speaker 4 of 4
Linda T. Vo, University of California, San Francisco, USA
T Cell Engineering from Human Pluripotent Stem Cells

Wednesday, February 14 | 5:00PM - 7:00PM
Emerging Concepts in the Development of Tumor Vaccines
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 1 of 5
* Dimitris Skokos, Regeneron Pharmaceuticals, USA


Wednesday, February 14 | 5:00PM - 7:00PM
Emerging Concepts in the Development of Tumor Vaccines
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 2 of 5
Ugur Sahin, BioNTech AG, Germany
Systemic RNA Delivery, Dendritic Cell Vaccines and Implications for Cancer Immunotherapy


Wednesday, February 14 | 5:00PM - 7:00PM
Emerging Concepts in the Development of Tumor Vaccines
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 3 of 5
Cornelis J. M. Melief, Leiden University Medical Center & ISA Pharmaceuticals BV, Netherlands
Combination Immunotherapy of Cancers Caused by High-Risk HPV16


Wednesday, February 14 | 5:00PM - 7:00PM
Emerging Concepts in the Development of Tumor Vaccines
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 4 of 5
Johanna Olweus, University of Oslo, Norway
Selecting Immunogenic Targets for Cancer Immunotherapy


Wednesday, February 14 | 5:00PM - 7:00PM
Emerging Concepts in the Development of Tumor Vaccines
This session is from Lymphocytes and Cancer
Room: Quandary Peak

Speaker 5 of 5
Samarth Hegde, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Tumor Antigenicity Accelerates Early Pancreatic Adenocarcinoma Progression


Wednesday, February 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, February 14 | 7:30PM - 10:00PM
Poster Session 3
Room: Colorado Rockies Ballroom


Thursday, February 15 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Thursday, February 15 | 8:00AM - 11:00AM
Beyond T Cells: HSC, T Progenitor and IPSCs II
Room: Grays/Longs Peak

Speaker 1 of 7
* Bruce R. Blazar, University of Minnesota, USA

Thursday, February 15 | 8:00AM - 11:00AM
Beyond T Cells: HSC, T Progenitor and IPSCs II
Room: Grays/Longs Peak

Speaker 2 of 7
Juan Carlos Zúñiga-Pflücker, Sunnybrook Research Institute, Canada
Generation of Human Progenitor T Cells from Stem Cells

Thursday, February 15 | 8:00AM - 11:00AM
Beyond T Cells: HSC, T Progenitor and IPSCs II
Room: Grays/Longs Peak

Speaker 3 of 7
Sjoukje J.C. van der Stegen, Memorial Sloan Kettering Cancer Center, USA
Development of CD8alphabeta+ CAR T Cells from Human Pluripotent Stem Cells

Thursday, February 15 | 8:00AM - 11:00AM
Beyond T Cells: HSC, T Progenitor and IPSCs II
Room: Grays/Longs Peak


Coffee Break

Thursday, February 15 | 8:00AM - 11:00AM
Beyond T Cells: HSC, T Progenitor and IPSCs II
Room: Grays/Longs Peak

Speaker 5 of 7
Jakub Tolar, University of Minnesota, USA
Gene-Edited Stem Cells: From Cloning to Clinic

Thursday, February 15 | 8:00AM - 11:00AM
Beyond T Cells: HSC, T Progenitor and IPSCs II
Room: Grays/Longs Peak

Speaker 6 of 7
Saar I. Gill, University of Pennsylvania, USA
Chimeric Antigen Receptor Macrophages for the Treatment of Solid Tumors

Thursday, February 15 | 8:00AM - 11:00AM
Beyond T Cells: HSC, T Progenitor and IPSCs II
Room: Grays/Longs Peak

Speaker 7 of 7
Katelyn Masiuk, University of California, Los Angeles, USA
Short Talk: Hematopoietic Stem Cell Gene Therapy for IPEX Syndrome

Thursday, February 15 | 8:00AM - 11:00AM
Combinatorial Treatments and their Effects on Lymphocyte Fun
ction in Cancer
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 1 of 7
* Ashley M. Laughney, Memorial Sloan Kettering Cancer Center, USA


Thursday, February 15 | 8:00AM - 11:00AM
Combinatorial Treatments and their Effects on Lymphocyte Fun
ction in Cancer
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 2 of 7
David G. DeNardo, Washington University Medical School, USA
The Pancreatic Tumor Microenvironment; Modulator of Tumor Progression and Response to Therapy


Thursday, February 15 | 8:00AM - 11:00AM
Combinatorial Treatments and their Effects on Lymphocyte Fun
ction in Cancer
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 3 of 7
Dimitris Skokos, Regeneron Pharmaceuticals, USA
T Cell Dysfunction and Combination Immunotherapy


Thursday, February 15 | 8:00AM - 11:00AM
Combinatorial Treatments and their Effects on Lymphocyte Fun
ction in Cancer
This session is from Lymphocytes and Cancer

Room: Quandary Peak


Coffee Break


Thursday, February 15 | 8:00AM - 11:00AM
Combinatorial Treatments and their Effects on Lymphocyte Fun
ction in Cancer
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 5 of 7
Michael A. Curran, University of Texas MD Anderson Cancer Center, USA
Optimizing T Cell Frequency and Function via Checkpoint Antibody / Vaccine Combinations


Thursday, February 15 | 8:00AM - 11:00AM
Combinatorial Treatments and their Effects on Lymphocyte Fun
ction in Cancer
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 6 of 7
Sjoerd H. van der Burg, Leiden University Medical Center, Netherlands
Combination Treatments to Modulate the Microenvironment and Boost Tumor-Specific T Cells


Thursday, February 15 | 8:00AM - 11:00AM
Combinatorial Treatments and their Effects on Lymphocyte Fun
ction in Cancer
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 7 of 7
Yuliya Pylayeva-Gupta, University of North Carolina at Chapel Hill, USA
Short Talk: IL-35+ B Cells Establish Immunosuppressive Network in Pancreatic Ductal Adenocarcinoma


Thursday, February 15 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, February 15 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 15 | 5:00PM - 6:45PM
Intersection of Genetic Editing and Cellular Therapy
Room: Grays/Longs Peak

Speaker 1 of 4
* Marcela V. Maus, Harvard Medical School, USA

Thursday, February 15 | 5:00PM - 6:45PM
Intersection of Genetic Editing and Cellular Therapy
Room: Grays/Longs Peak

Speaker 2 of 4
Alex Marson, University of California, San Francisco, USA
Reprogramming Human T Cell Circuitry

Thursday, February 15 | 5:00PM - 6:45PM
Intersection of Genetic Editing and Cellular Therapy
Room: Grays/Longs Peak

Speaker 3 of 4
Andrew M. Scharenberg, Casebia Therapeutics, USA
Engineering Regulatory T Cells for Inflammatory Disorders

Thursday, February 15 | 5:00PM - 6:45PM
Intersection of Genetic Editing and Cellular Therapy
Room: Grays/Longs Peak

Speaker 4 of 4
Carl H. June, University of Pennsylvania, USA
Adoptive Transfer with Genetically Edited T Cells


Thursday, February 15 | 5:00PM - 6:45PM
Future Directions for Next-Generation Sequencing: Genomics,
Epigenetics and Immunogenomics
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 1 of 4
* Iannis Aifantis, New York University School of Medicine, USA


Thursday, February 15 | 5:00PM - 6:45PM
Future Directions for Next-Generation Sequencing: Genomics,
Epigenetics and Immunogenomics
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 2 of 4
Ashley M. Laughney, Memorial Sloan Kettering Cancer Center, USA
Dissecting Tumor Cell Plasticity and Population Interactions Supporting Metastasis using Single Cell Genomics


Thursday, February 15 | 5:00PM - 6:45PM
Future Directions for Next-Generation Sequencing: Genomics,
Epigenetics and Immunogenomics
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 3 of 4
Mickey Atwal, Cold Spring Harbor Laboratory, USA
High-Throughput Profiling of T Cell Receptor Sequences in Cancer Immunotherapy


Thursday, February 15 | 5:00PM - 6:45PM
Future Directions for Next-Generation Sequencing: Genomics,
Epigenetics and Immunogenomics
This session is from Lymphocytes and Cancer

Room: Quandary Peak

Speaker 4 of 4
Rahul Satija, New York Genome Center, USA
Integrated Analysis of Single Cell Data across Modalities, Technologies and Species


Thursday, February 15 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Grays/Longs Peak


Thursday, February 15 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Lymphocytes and Cancer
Room: Quandary Peak


Thursday, February 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, February 15 | 8:00PM - 11:00PM
Entertainment
Room: Colorado Rockies Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, February 15 | 8:00PM - 11:00PM
Cash Bar
Room: Colorado Rockies Ballroom


Friday, February 16 | 10:24AM - 10:24AM
Departure


*Session Chair.