Web Desc
GPCR Structure and Function: Taking GPCR Drug Development and Discovery to the Next Level
Organizer(s): Roger K. Sunahara and Christian Felder
Date: February 16 - 20, 2018
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Sponsored by Novo Nordisk A/S and Theravance Biopharma
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Summary of Meeting:
G protein-coupled receptors (GPCRs) are a critical family of cell surface receptors that detect extracellular stimuli, facilitate intercellular communication and regulate cellular homeostasis. As such, GPCRs remain highly relevant drug discovery targets addressing key unmet medical needs. Recent advances in understanding GPCR signaling networks, coupled with the unraveling of structural details of GPCRs, their signaling partners and in some cases their signaling complexes, have enhanced our understanding of GPCR function. These advances have provided researchers the basic tools to interrogate critical but diverse aspects of GPCR signaling, such as receptor conformation, receptor-effector specificity and the role of receptor subcellular distribution, in signaling efficacy. All of these factors may influence ligand binding and therefore have impact on drug discovery. The availability of atomic-resolution structures of GPCRs alongside the introduction of functional coupling (e.g., biased signaling) is providing the potential for physiologically tailored and therefore disease-specific therapies. However, challenges remain as the design of small molecule tools and potential drugs is both labor-intensive and very costly, requiring large chemical library screening campaigns. In addition, improvements are still needed in GPCR ligand selectivity, signaling specificity and appropriate kinetics to achieve maximal efficacy and reasonable safety. Rational ligand design could significantly reduce both time and cost of drug discovery. Viable approaches are currently being explored through the combination of molecular dynamic simulations, GPCR crystallization and biophysical analysis. Drug efficacy and safety improvements are slow to emerge and can be addressed by the development of physiologically relevant GPCR ligands. Targeting allosteric sites, hetero- and homo-dimers and specific signaling pathways could provide such context- and disease-specific regulation. This conference will highlight the latest developments in GPCR structure/function, ligand discovery and design, intracellular signaling pathways and their impact on modern drug discovery.
Scholarship Deadline: October 17 2017
Discounted Abstract Deadline: October 17 2017
Abstract Deadline: November 15 2017
Discounted Registration Deadline: December 18 2017
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Novo Nordisk A/STheravance Biopharma
We gratefully acknowledge additional support from these exhibitors at this conference:
Thermo Fisher Scientific
We gratefully acknowledge additional support for this conference from:
Eurofins Pharma Discovery Services
Journal of General Physiology
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Heptares Therapeutics Ltd
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, February 16 | 4:00PM - 8:00PM
Arrival and Registration
Room: Eldorado Lounge


Friday, February 16 | 6:00PM - 8:00PM
Welcome Mixer
Room: Eldorado Lounge
No registration fees are used to fund alcohol served at this function.

Saturday, February 17 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Saturday, February 17 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado Grand Ballroom

Speaker 1 of 2
* Roger K. Sunahara, University of California, San Diego, USA

Saturday, February 17 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado Grand Ballroom

Speaker 2 of 2
Brian K. Kobilka, Stanford University School of Medicine, USA
The Structural Dynamics of GPCR Activation


Saturday, February 17 | 9:00AM - 11:15AM
Structure and Function of GPCRs I
Room: Eldorado Grand Ballroom
Cutting edge research in GPCR structure and function using state of the art structural and biochemical approaches.
Speaker 1 of 6
* Nicolas L. Villanueva, University of California, San Diego, USA

Saturday, February 17 | 9:00AM - 11:15AM
Structure and Function of GPCRs I
Room: Eldorado Grand Ballroom
Cutting edge research in GPCR structure and function using state of the art structural and biochemical approaches.
Speaker 2 of 6
Robert Scott Prosser, University of Toronto, Canada
Molecular Underpinnings of GPCR Pharmacology and Mechanisms of GPCR Activation: Spectroscopic Studies of the Adenosine A2A Receptor

Saturday, February 17 | 9:00AM - 11:15AM
Structure and Function of GPCRs I
Room: Eldorado Grand Ballroom
Cutting edge research in GPCR structure and function using state of the art structural and biochemical approaches.

Coffee Break

Saturday, February 17 | 9:00AM - 11:15AM
Structure and Function of GPCRs I
Room: Eldorado Grand Ballroom
Cutting edge research in GPCR structure and function using state of the art structural and biochemical approaches.
Speaker 4 of 6
Beili Wu, Shanghai Institute of Materia Medical, CAS, China
Structure of the Full-Length Glucagon Receptor

Saturday, February 17 | 9:00AM - 11:15AM
Structure and Function of GPCRs I
Room: Eldorado Grand Ballroom
Cutting edge research in GPCR structure and function using state of the art structural and biochemical approaches.
Speaker 5 of 6
Scott C. Blanchard, Weill Cornell Medicine, USA
Single-Molecule Analysis of Ligand Efficacy in ß2AR-G Protein Activation

Saturday, February 17 | 9:00AM - 11:15AM
Structure and Function of GPCRs I
Room: Eldorado Grand Ballroom
Cutting edge research in GPCR structure and function using state of the art structural and biochemical approaches.
Speaker 6 of 6
Yonghoon Kwon, POSTECH, South Korea
Short Talk: Dimeric b2-Adrenergic Receptor Regulates the Basal Activity Subjected to Inverse Agonism

Saturday, February 17 | 11:15AM - 5:00PM
On Own for Lunch


Saturday, February 17 | 11:15AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Saturday, February 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Saturday, February 17 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Saturday, February 17 | 5:00PM - 7:00PM
Structure and Function of GPCRs II
Room: Eldorado Grand Ballroom
Structural aspects of arrestin-GPCR complexes and their implication to signaling bias.
Speaker 1 of 5
* Vsevolod Katritch, University of Southern California, USA

Saturday, February 17 | 5:00PM - 7:00PM
Structure and Function of GPCRs II
Room: Eldorado Grand Ballroom
Structural aspects of arrestin-GPCR complexes and their implication to signaling bias.
Speaker 2 of 5
Tracy M. Handel, University of California, San Diego, USA
Structure and Signaling Mechanisms of G Protein-Coupled and ß-Arrestin-Biased Chemokine Receptors

Saturday, February 17 | 5:00PM - 7:00PM
Structure and Function of GPCRs II
Room: Eldorado Grand Ballroom
Structural aspects of arrestin-GPCR complexes and their implication to signaling bias.
Speaker 3 of 5
H. Eric Xu, Van Andel Institute, USA
Molecular Assembly of Rhodopsin with GRK1 and Arrestin

Saturday, February 17 | 5:00PM - 7:00PM
Structure and Function of GPCRs II
Room: Eldorado Grand Ballroom
Structural aspects of arrestin-GPCR complexes and their implication to signaling bias.
Speaker 4 of 5
Ka Young Chung, Sungkyunkwan University, South Korea
Conformational Mechanism of GPCR Signaling Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry

Saturday, February 17 | 5:00PM - 7:00PM
Structure and Function of GPCRs II
Room: Eldorado Grand Ballroom
Structural aspects of arrestin-GPCR complexes and their implication to signaling bias.
Speaker 5 of 5
Anita K. Nivedha, City of Hope, USA
Short Talk: Identifying Functional Hotspot Residues for Biased Ligand Design in G-protein Coupled Receptors

Saturday, February 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Saturday, February 17 | 7:30PM - 10:00PM
Poster Session 1
Room: Anasazi Ballroom


Sunday, February 18 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Sunday, February 18 | 8:00AM - 11:15AM
GPCRs: Naturally Great Drug Targets
Room: Eldorado Grand Ballroom
Use of cutting edge approaches in GPCR drug discovery and development.
Speaker 1 of 8
* Irina Kufareva, University of California, San Diego, USA

Sunday, February 18 | 8:00AM - 11:15AM
GPCRs: Naturally Great Drug Targets
Room: Eldorado Grand Ballroom
Use of cutting edge approaches in GPCR drug discovery and development.
Speaker 2 of 8
Nagarajan Vaidehi, City of Hope National Medical Center, USA
Information Pipelines: Forward and Reverse Allostery in GPCRs

Sunday, February 18 | 8:00AM - 11:15AM
GPCRs: Naturally Great Drug Targets
Room: Eldorado Grand Ballroom
Use of cutting edge approaches in GPCR drug discovery and development.
Speaker 3 of 8
Fiona H. Marshall, Heptares Therapeutics Ltd., UK
Using X-Ray Structures of GPCRs to Guide Drug Discovery - Challenges for Allosteric Modulators

Sunday, February 18 | 8:00AM - 11:15AM
GPCRs: Naturally Great Drug Targets
Room: Eldorado Grand Ballroom
Use of cutting edge approaches in GPCR drug discovery and development.

Coffee Break

Sunday, February 18 | 8:00AM - 11:15AM
GPCRs: Naturally Great Drug Targets
Room: Eldorado Grand Ballroom
Use of cutting edge approaches in GPCR drug discovery and development.
Speaker 5 of 8
Kathleen M. Caron, University of North Carolina at Chapel Hill, USA
RAMPS: The Natural Allosteric Modulators and their Role in Disease

Sunday, February 18 | 8:00AM - 11:15AM
GPCRs: Naturally Great Drug Targets
Room: Eldorado Grand Ballroom
Use of cutting edge approaches in GPCR drug discovery and development.
Speaker 6 of 8
Daniel Rosenbaum, University of Texas Southwestern Medical Center, USA
Structure-Function of the CB1 Cannabinoid Receptor

Sunday, February 18 | 8:00AM - 11:15AM
GPCRs: Naturally Great Drug Targets
Room: Eldorado Grand Ballroom
Use of cutting edge approaches in GPCR drug discovery and development.
Speaker 7 of 8
Kaushik Sarkar, UCB Celltech, UK
Short Talk: Discovery of Antibodies against PTH1R, A Class B GPCR: Characterisation of their Binding and Impact on PTH1R Function

Sunday, February 18 | 8:00AM - 11:15AM
GPCRs: Naturally Great Drug Targets
Room: Eldorado Grand Ballroom
Use of cutting edge approaches in GPCR drug discovery and development.
Speaker 8 of 8
Franziska Marie Heydenreich, University of Montreal, Canada
Short Talk: The Inner Workings of a GPCR: Molecular Basis for Signaling Bias and Functional Selectivity

Sunday, February 18 | 11:15AM - 5:00PM
On Own for Lunch


Sunday, February 18 | 11:15AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Sunday, February 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Sunday, February 18 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Sunday, February 18 | 5:00PM - 7:00PM
Novel Approaches to Drug Action and Discovery
Room: Eldorado Grand Ballroom
Use of novel approaches to study the mechanism of action of drugs and their future use in drug discovery.
Speaker 1 of 5
* Dmitry Veprintsev, University of Nottingham, UK

Sunday, February 18 | 5:00PM - 7:00PM
Novel Approaches to Drug Action and Discovery
Room: Eldorado Grand Ballroom
Use of novel approaches to study the mechanism of action of drugs and their future use in drug discovery.
Speaker 2 of 5
Dirk Trauner, New York University, USA
How to Convert Any GPCR into a Photoreceptor

Sunday, February 18 | 5:00PM - 7:00PM
Novel Approaches to Drug Action and Discovery
Room: Eldorado Grand Ballroom
Use of novel approaches to study the mechanism of action of drugs and their future use in drug discovery.
Speaker 3 of 5
Bryan Roth, University of North Carolina at Chapel Hill, USA
New Technologies for Illuminating the Druggable GPCR-ome

Sunday, February 18 | 5:00PM - 7:00PM
Novel Approaches to Drug Action and Discovery
Room: Eldorado Grand Ballroom
Use of novel approaches to study the mechanism of action of drugs and their future use in drug discovery.
Speaker 4 of 5
Jeffrey Jeffrey Conn, Vanderbilt University, USA
Genetic Insights Lead to Discovery of Selective mGlu1 and mGlu3 Metabotropic Glutamate Receptor PAMs as Potential Treatments for Schizophrenia

Sunday, February 18 | 5:00PM - 7:00PM
Novel Approaches to Drug Action and Discovery
Room: Eldorado Grand Ballroom
Use of novel approaches to study the mechanism of action of drugs and their future use in drug discovery.
Speaker 5 of 5
Guan-Da Syu, Johns Hopkins Medicine, USA
Short Talk: Virion Display (VirD) Approach to Characterizing Non-Odorant GPCRs in Humans

Sunday, February 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Sunday, February 18 | 7:30PM - 10:00PM
Poster Session 2
Room: Anasazi Ballroom


Monday, February 19 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Monday, February 19 | 8:00AM - 11:15AM
Complexity of Cellular Signaling
Room: Eldorado Grand Ballroom
Complexity of GPCR-mediated signaling in cells where cellular context and sub-cellular distribution may play a role in specific signal transduction pathway activation.
Speaker 1 of 8
* Jacob Mahoney, Stanford University, USA

Monday, February 19 | 8:00AM - 11:15AM
Complexity of Cellular Signaling
Room: Eldorado Grand Ballroom
Complexity of GPCR-mediated signaling in cells where cellular context and sub-cellular distribution may play a role in specific signal transduction pathway activation.
Speaker 2 of 8
Mark von Zastrow, University of California, San Francisco, USA
Subcellular Organization of GPCR Signaling

Monday, February 19 | 8:00AM - 11:15AM
Complexity of Cellular Signaling
Room: Eldorado Grand Ballroom
Complexity of GPCR-mediated signaling in cells where cellular context and sub-cellular distribution may play a role in specific signal transduction pathway activation.
Speaker 3 of 8
Madan Babu Mohan, MRC Laboratory of Molecular Biology, UK
Pharmacogenomics of G-Protein Coupled Receptor Drug Targets

Monday, February 19 | 8:00AM - 11:15AM
Complexity of Cellular Signaling
Room: Eldorado Grand Ballroom
Complexity of GPCR-mediated signaling in cells where cellular context and sub-cellular distribution may play a role in specific signal transduction pathway activation.

Coffee Break

Monday, February 19 | 8:00AM - 11:15AM
Complexity of Cellular Signaling
Room: Eldorado Grand Ballroom
Complexity of GPCR-mediated signaling in cells where cellular context and sub-cellular distribution may play a role in specific signal transduction pathway activation.
Speaker 5 of 8
Ron O. Dror, Stanford University, USA
One Receptor, Many Partners: How Do GPCRs Stimulate Diverse Signaling Proteins?

Monday, February 19 | 8:00AM - 11:15AM
Complexity of Cellular Signaling
Room: Eldorado Grand Ballroom
Complexity of GPCR-mediated signaling in cells where cellular context and sub-cellular distribution may play a role in specific signal transduction pathway activation.
Speaker 6 of 8
Martin J. Lohse, Max Delbrück Center for Molecular Medicine, Germany
The Kinetics of Biased Signaling in GPCRs

Monday, February 19 | 8:00AM - 11:15AM
Complexity of Cellular Signaling
Room: Eldorado Grand Ballroom
Complexity of GPCR-mediated signaling in cells where cellular context and sub-cellular distribution may play a role in specific signal transduction pathway activation.
Speaker 7 of 8
Nevin A. Lambert, Medical College of Georgia, USA
Short Talk: Cellular Assays Based on Mini G Proteins

Monday, February 19 | 8:00AM - 11:15AM
Complexity of Cellular Signaling
Room: Eldorado Grand Ballroom
Complexity of GPCR-mediated signaling in cells where cellular context and sub-cellular distribution may play a role in specific signal transduction pathway activation.
Speaker 8 of 8
Ieva Sutkeviciute, University of Pittsburgh, USA
Short Talk: Structural Determinants and Physiological Implications of PTH Receptor Endosomal Signaling

Monday, February 19 | 11:15AM - 5:00PM
On Own for Lunch


Monday, February 19 | 11:15AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Monday, February 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Monday, February 19 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Monday, February 19 | 5:00PM - 7:00PM
The GPCR Superfamily: Broad Mechanisms of Action
Room: Eldorado Grand Ballroom
Broad mechanisms of activation of various members of the GPCR superfamily and their implications in disease.
Speaker 1 of 5
* Graeme Milligan, University of Glasgow, UK

Monday, February 19 | 5:00PM - 7:00PM
The GPCR Superfamily: Broad Mechanisms of Action
Room: Eldorado Grand Ballroom
Broad mechanisms of activation of various members of the GPCR superfamily and their implications in disease.
Speaker 2 of 5
Gregory Tall, University of Michigan Medical School, USA
Adhesion GPCRs: A One and Done Family of Receptors and their Implications in Disease

Monday, February 19 | 5:00PM - 7:00PM
The GPCR Superfamily: Broad Mechanisms of Action
Room: Eldorado Grand Ballroom
Broad mechanisms of activation of various members of the GPCR superfamily and their implications in disease.
Speaker 3 of 5
Susan G. Amara, NIMH, National Institutes of Health, USA
GPCR Signaling in Dopamine Neurons: An Intracellular Trace-Amine Receptor, TAAR1, Mediates the Actions of Amphetamines

Monday, February 19 | 5:00PM - 7:00PM
The GPCR Superfamily: Broad Mechanisms of Action
Room: Eldorado Grand Ballroom
Broad mechanisms of activation of various members of the GPCR superfamily and their implications in disease.
Speaker 4 of 5
Patrick M. Sexton, Monash University, Australia
Structure and Function of Class B GPCRs

Monday, February 19 | 5:00PM - 7:00PM
The GPCR Superfamily: Broad Mechanisms of Action
Room: Eldorado Grand Ballroom
Broad mechanisms of activation of various members of the GPCR superfamily and their implications in disease.
Speaker 5 of 5
Benjamin R. Myers, University of Utah School of Medicine, USA
Short Talk: Dissecting the Regulation of the 7TM Oncoprotein Smoothened Using a New Set of in vitro and Cell-Based Tools

Monday, February 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, February 19 | 7:30PM - 10:00PM
Poster Session 3
Room: Anasazi Ballroom


Tuesday, February 20 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Tuesday, February 20 | 8:00AM - 11:15AM
GPCRs in vivo: Implications in Disease
Room: Eldorado Grand Ballroom
GPCR signaling in disease using various animal models to predict and/or simulate human disease.
Speaker 1 of 8
* Debbie L. Hay, University of Auckland, New Zealand

Tuesday, February 20 | 8:00AM - 11:15AM
GPCRs in vivo: Implications in Disease
Room: Eldorado Grand Ballroom
GPCR signaling in disease using various animal models to predict and/or simulate human disease.
Speaker 2 of 8
Arthur Christopoulos, Monash University, Australia
GPCR Allosteric Modulators: Discovery and Relevance to Disease Context

Tuesday, February 20 | 8:00AM - 11:15AM
GPCRs in vivo: Implications in Disease
Room: Eldorado Grand Ballroom
GPCR signaling in disease using various animal models to predict and/or simulate human disease.
Speaker 3 of 8
Michael R. Bruchas, Washington University School of Medicine, USA
Optical Approaches for Dissecting GPCR Signaling in Motivated Behavior

Tuesday, February 20 | 8:00AM - 11:15AM
GPCRs in vivo: Implications in Disease
Room: Eldorado Grand Ballroom
GPCR signaling in disease using various animal models to predict and/or simulate human disease.

Coffee Break

Tuesday, February 20 | 8:00AM - 11:15AM
GPCRs in vivo: Implications in Disease
Room: Eldorado Grand Ballroom
GPCR signaling in disease using various animal models to predict and/or simulate human disease.
Speaker 5 of 8
J. Silvio Gutkind, University of California, San Diego, USA
GPCR and G Protein Mutations in Cancer

Tuesday, February 20 | 8:00AM - 11:15AM
GPCRs in vivo: Implications in Disease
Room: Eldorado Grand Ballroom
GPCR signaling in disease using various animal models to predict and/or simulate human disease.
Speaker 6 of 8
Andrew B. Tobin, University of Glasgow, Scotland
From Cognition to Seizures: Novel Molecular Mechanism Underlying Key Muscarinic Receptor Action


Tuesday, February 20 | 8:00AM - 11:15AM
GPCRs in vivo: Implications in Disease
Room: Eldorado Grand Ballroom
GPCR signaling in disease using various animal models to predict and/or simulate human disease.
Speaker 7 of 8
Li Yang, East Carolina University, USA
Short Talk: Proton-Sensing GPCRs in Inflammation and Cancer

Tuesday, February 20 | 8:00AM - 11:15AM
GPCRs in vivo: Implications in Disease
Room: Eldorado Grand Ballroom
GPCR signaling in disease using various animal models to predict and/or simulate human disease.
Speaker 8 of 8
Nicola J. Smith, Victor Chang Cardiac Research Institute, Australia
Short Talk: Orphan Receptor GPR37L1 Contributes to the Sexual Dimorphism of Central Cardiovascular Control

Tuesday, February 20 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, February 20 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Tuesday, February 20 | 5:00PM - 7:00PM
Drug Discovery and the Realistic Process
Room: Eldorado Grand Ballroom
Drug discovery and development from the industrial perspective. The discussion will focus on how target validation, PK/PD, medicinal chemistry, clinical trials and time influence successful drug development.
Speaker 1 of 5
* Sophie J. Bradley, University of Glasgow, UK

Tuesday, February 20 | 5:00PM - 7:00PM
Drug Discovery and the Realistic Process
Room: Eldorado Grand Ballroom
Drug discovery and development from the industrial perspective. The discussion will focus on how target validation, PK/PD, medicinal chemistry, clinical trials and time influence successful drug development.
Speaker 2 of 5
Kurt Rasmussen, Eli Lilly and Company, USA
Development of Novel Treatments for Opiate Addiction

Tuesday, February 20 | 5:00PM - 7:00PM
Drug Discovery and the Realistic Process
Room: Eldorado Grand Ballroom
Drug discovery and development from the industrial perspective. The discussion will focus on how target validation, PK/PD, medicinal chemistry, clinical trials and time influence successful drug development.
Speaker 3 of 5
Stephen Hitchcock, Takeda Pharmaceuticals, USA
The Journey from Expression Profiling to Clinical Development: Identification of Cell Type Selective Orphan GPCRs and the Discovery of Surrogate Ligands to Probe their Therapeutic Potential

Tuesday, February 20 | 5:00PM - 7:00PM
Drug Discovery and the Realistic Process
Room: Eldorado Grand Ballroom
Drug discovery and development from the industrial perspective. The discussion will focus on how target validation, PK/PD, medicinal chemistry, clinical trials and time influence successful drug development.
Speaker 4 of 5
Kevin M. Biglan, Eli Lilly and Company, USA
Preclinical Profile of a Dopamine D1 Potentiator Suggests Therapeutic Utility in Neuropsychiatric Disorders

Tuesday, February 20 | 5:00PM - 7:00PM
Drug Discovery and the Realistic Process
Room: Eldorado Grand Ballroom
Drug discovery and development from the industrial perspective. The discussion will focus on how target validation, PK/PD, medicinal chemistry, clinical trials and time influence successful drug development.
Speaker 5 of 5
Joshua Allen, Oncoceutics, Inc., USA
Short Talk: Differentiated Receptor Pharmacology of Imipridone ONC201: The First DRD2 Antagonist in Clinical Development for Oncology

Tuesday, February 20 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Eldorado Grand Ballroom


Tuesday, February 20 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, February 20 | 8:00PM - 11:00PM
Entertainment
Room: Anasazi Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Tuesday, February 20 | 8:00PM - 11:00PM
Cash Bar
Room: Anasazi Ballroom


Wednesday, February 21 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.