Web Desc
Regulation and Dysregulation of Innate Immunity in Disease
Organizer(s): Lynda M. Stuart, Kathryn J. Moore and Kate L. Jeffrey
Date: February 18 - 22, 2018
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Supported by the Directors' Fund
Summary of Meeting:
The innate immune system is fundamental to protect us from pathogens. Although the core components were first elucidated in model organisms such as Drosophila and mice, exactly how they are regulated in human health and contribute to disease remains to be fully defined. Over the past several years, our ability to study the innate immune response has been enabled by a number of transformative tools that can be used to assess gene expression, cellular physiology and gene function. Such technological advances have begun to reveal new components of the innate immune system and have led to a better understanding of its regulation and dysregulation. Importantly, these new insights have allowed us to better understand the pathophysiological basis of certain human diseases and to identify new therapeutic targets to alleviate them. This conference aims to gather different viewpoints in the field of innate immunity to discuss advances in signaling and regulatory networks and to understand how their dysregulation contributes to immunopathologies and auto-inflammatory conditions.
Scholarship Deadline: October 18 2017
Discounted Abstract Deadline: October 18 2017
Abstract Deadline: November 16 2017
Discounted Registration Deadline: December 18 2017
We gratefully acknowledge additional support for this conference from:
Adipogen InternationalKenneth Rainin Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI136364-01
Funding for this conference was made possible (in part) by 1 R13 AI136364-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 18 | 4:00PM - 8:00PM
Arrival and Registration
Room: British/Columbia Foyer


Sunday, February 18 | 6:00PM - 8:00PM
Welcome Mixer
Room: British/Columbia Foyer
No registration fees are used to fund alcohol served at this function.

Monday, February 19 | 7:30AM - 8:30AM
Breakfast
Room: Columbia Ballroom


Monday, February 19 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: British Ballroom

Speaker 1 of 2
* Lynda M. Stuart, Bill & Melinda Gates Foundation, USA

Monday, February 19 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: British Ballroom

Speaker 2 of 2
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Regulation of Inflammation by Noncoding RNAs and Nucleic Acid Binding Proteins

Monday, February 19 | 9:30AM - 11:45AM
Looking for More: Screening in the Innate Immune System
Room: British Ballroom

Speaker 1 of 7
* Kate L. Jeffrey, Harvard Medical School, USA

Monday, February 19 | 9:30AM - 11:45AM
Looking for More: Screening in the Innate Immune System
Room: British Ballroom

Speaker 2 of 7
* Kathryn J. Moore, New York University Medical Center, USA

Monday, February 19 | 9:30AM - 11:45AM
Looking for More: Screening in the Innate Immune System
Room: British Ballroom

Speaker 3 of 7
Carl L. Hansen, University of British Columbia, Canada
Single-Cell Analysis for Deep Screening of Human Antibody Responses

Monday, February 19 | 9:30AM - 11:45AM
Looking for More: Screening in the Innate Immune System
Room: British Ballroom


Coffee Break

Monday, February 19 | 9:30AM - 11:45AM
Looking for More: Screening in the Innate Immune System
Room: British Ballroom

Speaker 5 of 7
Lynda M. Stuart, Bill & Melinda Gates Foundation, USA
Transposon Mutagenesis Screens for Host Resistance

Monday, February 19 | 9:30AM - 11:45AM
Looking for More: Screening in the Innate Immune System
Room: British Ballroom

Speaker 6 of 7
Michael Bassik, Stanford University, USA
Systematic Exploration of Endocytosis and Phagocytosis Pathways Using Genome-Wide CRISPR/Cas9 Screens and Genetic Interaction Maps

Monday, February 19 | 9:30AM - 11:45AM
Looking for More: Screening in the Innate Immune System
Room: British Ballroom

Speaker 7 of 7
Iain D.C. Fraser, NIAID, National Institutes of Health, USA
Short Talk: Genome-Wide Screening Combined with an Iterative Bioinformatic Analysis Model Identifies Critical Roles for
Protein Degradation and Alternative Splicing in TLR-Induced Macrophage Activation


Monday, February 19 | 11:45AM - 5:00PM
On Own for Lunch


Monday, February 19 | 11:45AM - 1:00PM
Poster Setup
Room: Columbia Ballroom


Monday, February 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Columbia Ballroom


Monday, February 19 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Monday, February 19 | 5:00PM - 7:00PM
Gene Regulatory Networks in Innate Immunity
Room: British Ballroom

Speaker 1 of 6
* Jose Ordovas-Montanes, Boston Children's Hospital and Harvard Medical School, USA

Monday, February 19 | 5:00PM - 7:00PM
Gene Regulatory Networks in Innate Immunity
Room: British Ballroom

Speaker 2 of 6
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Monday, February 19 | 5:00PM - 7:00PM
Gene Regulatory Networks in Innate Immunity
Room: British Ballroom

Speaker 3 of 6
Julian C. Knight, University of Oxford, UK
Insights into Regulation of Innate Immune Responses Leveraging Human Genetic Variation

Monday, February 19 | 5:00PM - 7:00PM
Gene Regulatory Networks in Innate Immunity
Room: British Ballroom

Speaker 4 of 6
Alex K. Shalek, Massachusetts Institute of Technology, USA
Learning More by Looking at Less – Single Cell Analyses of Pathogen Responses

Monday, February 19 | 5:00PM - 7:00PM
Gene Regulatory Networks in Innate Immunity
Room: British Ballroom

Speaker 5 of 6
Matthew L. Albert, Genentech, Inc., USA
Geographical Variations in the Human Innate Immune Response to Pathogens

Monday, February 19 | 5:00PM - 7:00PM
Gene Regulatory Networks in Innate Immunity
Room: British Ballroom

Speaker 6 of 6
Hiroyuki Oshiumi, Kumamoto University, Japan
Short Talk: miR-451a in Blood-Circulating Extracellular Vesicles Controls the Innate Immune Response of Macrophages

Monday, February 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Columbia Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, February 19 | 7:30PM - 10:00PM
Poster Session 1
Room: Columbia Ballroom


Tuesday, February 20 | 7:30AM - 8:30AM
Breakfast
Room: Columbia Ballroom


Tuesday, February 20 | 8:30AM - 11:45AM
Epigenetic Regulation of Host Defense
Room: British Ballroom

Speaker 1 of 8
* Eicke Latz, University of Bonn, Germany

Tuesday, February 20 | 8:30AM - 11:45AM
Epigenetic Regulation of Host Defense
Room: British Ballroom

Speaker 2 of 8
Kate L. Jeffrey, Harvard Medical School, USA
Loss of Epigenome Reader SP140 Disrupts Macrophage Transcriptional Programs and Contributes to Crohn’s Disease

Tuesday, February 20 | 8:30AM - 11:45AM
Epigenetic Regulation of Host Defense
Room: British Ballroom

Speaker 3 of 8
Gioacchino Natoli, Humanitas University, Italy
Genomic Landscapes in Inflammation

Tuesday, February 20 | 8:30AM - 11:45AM
Epigenetic Regulation of Host Defense
Room: British Ballroom


Coffee Break

Tuesday, February 20 | 8:30AM - 11:45AM
Epigenetic Regulation of Host Defense
Room: British Ballroom

Speaker 5 of 8
Mélanie Hamon, Institut Pasteur, France
Streptococcus Pneumoniae-Induced Epigenetic Alterations

Tuesday, February 20 | 8:30AM - 11:45AM
Epigenetic Regulation of Host Defense
Room: British Ballroom

Speaker 6 of 8
Stephen T. Smale, University of California, Los Angeles, USA
Molecular Mechanisms Regulating Stimulus-Specific Transcriptional Cascades

Tuesday, February 20 | 8:30AM - 11:45AM
Epigenetic Regulation of Host Defense
Room: British Ballroom

Speaker 7 of 8
Steven Z. Josefowicz, Rockefeller University, USA
Short Talk: Signaling to Chromatin for a Rapid and Robust Inflammatory Response

Tuesday, February 20 | 8:30AM - 11:45AM
Epigenetic Regulation of Host Defense
Room: British Ballroom

Speaker 8 of 8
Annette E. Neele, University of Amsterdam, Netherlands
Short Talk: Fine-Tuning of DNA Methylation during the Differentiation and Activation of Human Macrophages

Tuesday, February 20 | 11:45AM - 5:00PM
On Own for Lunch


Tuesday, February 20 | 11:45AM - 1:00PM
Poster Setup
Room: Columbia Ballroom


Tuesday, February 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Columbia Ballroom


Tuesday, February 20 | 3:00PM - 4:30PM
Workshop 1
Room: British Ballroom

Speaker 1 of 7
* Daniel Mucida, Rockefeller University, USA

Tuesday, February 20 | 3:00PM - 4:30PM
Workshop 1
Room: British Ballroom

Speaker 2 of 7
* Mélanie Hamon, Institut Pasteur, France

Tuesday, February 20 | 3:00PM - 4:30PM
Workshop 1
Room: British Ballroom

Speaker 3 of 7
Aditya Murthy, Genentech, Inc., USA
Selective Autophagy of the Innate Adaptor TRIF Regulates Inflammatory Signaling

Tuesday, February 20 | 3:00PM - 4:30PM
Workshop 1
Room: British Ballroom

Speaker 4 of 7
Travis K. Hughes, Harvard Medical School and MIT, USA
Understanding the Multi-Cellular Ecosystem of M. tuberculosis granulomas using High-Throughput Single-Cell mRNA Sequencing

Tuesday, February 20 | 3:00PM - 4:30PM
Workshop 1
Room: British Ballroom

Speaker 5 of 7
Jin Billy Li, Stanford University, USA
ADAR1 RNA editing mediated dsRNA sensing by MDA5

Tuesday, February 20 | 3:00PM - 4:30PM
Workshop 1
Room: British Ballroom

Speaker 6 of 7
Hans-Christian Reinecker, Massachusetts General Hospital, USA
The GEF-H1 Innate Immune Pathway Controls Anti-Tumor Immunity by Signaling Microtubule Depolymerization in Dendritic Cells

Tuesday, February 20 | 3:00PM - 4:30PM
Workshop 1
Room: British Ballroom

Speaker 7 of 7
Jose Ordovas-Montanes, Boston Children's Hospital and Harvard Medical School, USA
Barrier Dysfunction in Human Type 2 Immunity Arises from an Altered Basal Progenitor Cell State and Reduced Epithelial Cellular Diversity

Tuesday, February 20 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Tuesday, February 20 | 5:00PM - 7:00PM
Innate Defense at the Mucosa
Room: British Ballroom

Speaker 1 of 6
* Javier E. Irazoqui, University of Massachusetts Medical School, USA

Tuesday, February 20 | 5:00PM - 7:00PM
Innate Defense at the Mucosa
Room: British Ballroom

Speaker 2 of 6
* Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA

Tuesday, February 20 | 5:00PM - 7:00PM
Innate Defense at the Mucosa
Room: British Ballroom

Speaker 3 of 6
Ramnik Xavier, Massachusetts General Hospital, USA
Microbiome and Mucosal Immunity

Tuesday, February 20 | 5:00PM - 7:00PM
Innate Defense at the Mucosa
Room: British Ballroom

Speaker 4 of 6
P'ng Loke, New York University School of Medicine, USA
Alternatively Activated Macrophages of Tissue or Monocyte Origin

Tuesday, February 20 | 5:00PM - 7:00PM
Innate Defense at the Mucosa
Room: British Ballroom

Speaker 5 of 6
Daniel Mucida, Rockefeller University, USA
Tissue Adaptation of Intestinal Macrophages

Tuesday, February 20 | 5:00PM - 7:00PM
Innate Defense at the Mucosa
Room: British Ballroom

Speaker 6 of 6
Le Son Tran, Monash University, Australia
Short Talk: NOD1 Sensing of Helicobacter Pylori Infection Mediates Processing of Pro-Interleukin-18 in Gastric Epithelial Cells to Maintain Tissue Homeostasis

Tuesday, February 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Columbia Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, February 20 | 7:30PM - 10:00PM
Poster Session 2
Room: Columbia Ballroom


Wednesday, February 21 | 7:30AM - 8:30AM
Breakfast
Room: Columbia Ballroom


Wednesday, February 21 | 8:30AM - 11:30AM
Entraining Immunity
Room: British Ballroom

Speaker 1 of 8
* Kate L. Jeffrey, Harvard Medical School, USA

Wednesday, February 21 | 8:30AM - 11:30AM
Entraining Immunity
Room: British Ballroom

Speaker 2 of 8
* Steven Z. Josefowicz, Rockefeller University, USA

Wednesday, February 21 | 8:30AM - 11:30AM
Entraining Immunity
Room: British Ballroom

Speaker 3 of 8
Mihai G. Netea, Radboud University, Netherlands
Trained Immunity: A Memory for Innate Host Defense

Wednesday, February 21 | 8:30AM - 11:30AM
Entraining Immunity
Room: British Ballroom

Speaker 4 of 8
Judith E. Allen, University of Manchester, UK
Macrophage Education on Site

Wednesday, February 21 | 8:30AM - 11:30AM
Entraining Immunity
Room: British Ballroom


Coffee Break

Wednesday, February 21 | 8:30AM - 11:30AM
Entraining Immunity
Room: British Ballroom

Speaker 6 of 8
Eicke Latz, University of Bonn, Germany
Innate Immune Memory of Western Diet

Wednesday, February 21 | 8:30AM - 11:30AM
Entraining Immunity
Room: British Ballroom

Speaker 7 of 8
Musa M. Mhlanga, Radboud Institute for Molecular Life Sciences, Netherlands
Immune Genes Are Primed for Rapid Transcription by Proximal lncRNAs Located in Preformed Nuclear Compartments

Wednesday, February 21 | 8:30AM - 11:30AM
Entraining Immunity
Room: British Ballroom

Speaker 8 of 8
Vanessa Frodermann, Massachusetts General Hospital, USA
Short Talk: Voluntary Exercise Reduces Hematopoiesis

Wednesday, February 21 | 11:30AM - 5:00PM
On Own for Lunch


Wednesday, February 21 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Wednesday, February 21 | 5:00PM - 7:00PM
Metabolic Control of Innate Immune Cells
Room: British Ballroom

Speaker 1 of 5
* Fred Sheedy, Trinity College Dublin, Ireland

Wednesday, February 21 | 5:00PM - 7:00PM
Metabolic Control of Innate Immune Cells
Room: British Ballroom

Speaker 2 of 5
Kathryn J. Moore, New York University Medical Center, USA
Noncoding RNAs Coordinate the Physiology of Innate Immune Cells

Wednesday, February 21 | 5:00PM - 7:00PM
Metabolic Control of Innate Immune Cells
Room: British Ballroom

Speaker 3 of 5
Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolic Control of Myeloid Responses

Wednesday, February 21 | 5:00PM - 7:00PM
Metabolic Control of Innate Immune Cells
Room: British Ballroom

Speaker 4 of 5
Javier E. Irazoqui, University of Massachusetts Medical School, USA
TFEB: From Lysosome Storage to Innate Defense

Wednesday, February 21 | 5:00PM - 7:00PM
Metabolic Control of Innate Immune Cells
Room: British Ballroom

Speaker 5 of 5
Sonia Sharma, La Jolla Institute for Allergy & Immunology, USA
Short Talk: Metabolic-Epigenetic Dysregulation of Cell-Intrinsic Innate Immunity in a Disease of Systemic Inflammation

Wednesday, February 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Columbia Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, February 22 | 7:30AM - 8:30AM
Breakfast
Room: Columbia Ballroom


Thursday, February 22 | 8:30AM - 11:45AM
In the Balance: Immunodeficiencies and Auto-Inflammation
Room: British Ballroom

Speaker 1 of 9
* Adam Lacy-Hulbert, Benaroya Research Institute, USA

Thursday, February 22 | 8:30AM - 11:45AM
In the Balance: Immunodeficiencies and Auto-Inflammation
Room: British Ballroom

Speaker 2 of 9
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

Thursday, February 22 | 8:30AM - 11:45AM
In the Balance: Immunodeficiencies and Auto-Inflammation
Room: British Ballroom

Speaker 3 of 9
Fred Sheedy, Trinity College Dublin, Ireland
Defective Immunity Against TB via the Modulation of Macrophage Metabolism by Anti-Inflammatory MiR-21

Thursday, February 22 | 8:30AM - 11:45AM
In the Balance: Immunodeficiencies and Auto-Inflammation
Room: British Ballroom

Speaker 4 of 9
Andrew Oberst, University of Washington, USA
The RIP Kinases as Modulators of Inflammation and Immunity

Thursday, February 22 | 8:30AM - 11:45AM
In the Balance: Immunodeficiencies and Auto-Inflammation
Room: British Ballroom


Coffee Break

Thursday, February 22 | 8:30AM - 11:45AM
In the Balance: Immunodeficiencies and Auto-Inflammation
Room: British Ballroom

Speaker 6 of 9
Kim Newton, Genentech, Inc., USA
Cell Death as a Driver of Inflammation

Thursday, February 22 | 8:30AM - 11:45AM
In the Balance: Immunodeficiencies and Auto-Inflammation
Room: British Ballroom

Speaker 7 of 9
Virginia Pascual, Cornell University, USA
Adding New Pieces to the Human SLE Puzzle

Thursday, February 22 | 8:30AM - 11:45AM
In the Balance: Immunodeficiencies and Auto-Inflammation
Room: British Ballroom

Speaker 8 of 9
Hachung Chung, Rockefeller University, USA
Short Talk: Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown during the IFN Response

Thursday, February 22 | 8:30AM - 11:45AM
In the Balance: Immunodeficiencies and Auto-Inflammation
Room: British Ballroom

Speaker 9 of 9
Liudmila Andreeva, Gene Center Munich, LMU Munich, Germany
Short Talk: GAS Forms DNA-Protein Ladders for Cooperative Sensing of Long and TFAM/HMGB-Bound DNA

Thursday, February 22 | 11:45AM - 5:00PM
On Own for Lunch


Thursday, February 22 | 3:00PM - 4:30PM
Workshop 2
Room: British Ballroom

Speaker 1 of 8
* Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany

Thursday, February 22 | 3:00PM - 4:30PM
Workshop 2
Room: British Ballroom

Speaker 2 of 8
* Kim Newton, Genentech, Inc., USA

Thursday, February 22 | 3:00PM - 4:30PM
Workshop 2
Room: British Ballroom

Speaker 3 of 8
Zack Grimmett, University of California, San Francisco, USA
Changes in Expression of Gasdermin-Family Proteins during Monocyte to Macrophage Differentiation May Confer Susceptibility to Inflammatory Cell Death

Thursday, February 22 | 3:00PM - 4:30PM
Workshop 2
Room: British Ballroom

Speaker 4 of 8
Rosario Luque Martin, University of Amsterdam, Netherlands
A Screening Approach to Identify Epigenetic Compounds that Modulate Macrophage Activation

Thursday, February 22 | 3:00PM - 4:30PM
Workshop 2
Room: British Ballroom

Speaker 5 of 8
Cole M. Dovey, Colorado College, USA
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis Downstream of RIPK3

Thursday, February 22 | 3:00PM - 4:30PM
Workshop 2
Room: British Ballroom

Speaker 6 of 8
Chris Cox, Genentech, Inc., USA
Interleukin 1 Controls Susceptibility to Intestinal Pathogens by Directing a Stromal-Stem Cell Axis Required for Epithelial Regeneration

Thursday, February 22 | 3:00PM - 4:30PM
Workshop 2
Room: British Ballroom

Speaker 7 of 8
Sophie Elisabeth Zahalka, Medical University of Vienna, Austria
Exploring Trained Immunity in Lung Infection


Thursday, February 22 | 3:00PM - 4:30PM
Workshop 2
Room: British Ballroom

Speaker 8 of 8
Hao-Sen Chiang, National Taiwan University, Taiwan
DNase I Treatment Suppresses Experimental Colitis in Mice by Reducing Colonic Neutrophil Extracellular Trap Formation

Thursday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Thursday, February 22 | 5:00PM - 6:45PM
Pyroptosis, Necroptosis and Inflammatory Death
Room: British Ballroom

Speaker 1 of 5
* Judith E. Allen, University of Manchester, UK

Thursday, February 22 | 5:00PM - 6:45PM
Pyroptosis, Necroptosis and Inflammatory Death
Room: British Ballroom

Speaker 2 of 5
* Kathryn J. Moore, New York University Medical Center, USA

Thursday, February 22 | 5:00PM - 6:45PM
Pyroptosis, Necroptosis and Inflammatory Death
Room: British Ballroom

Speaker 3 of 5
Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Regulation of Inflammasome Activation and Cell Death

Thursday, February 22 | 5:00PM - 6:45PM
Pyroptosis, Necroptosis and Inflammatory Death
Room: British Ballroom

Speaker 4 of 5
Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Phagocyte Responses to Dying Cells

Thursday, February 22 | 5:00PM - 6:45PM
Pyroptosis, Necroptosis and Inflammatory Death
Room: British Ballroom

Speaker 5 of 5
Vishva M. Dixit, Genentech, Inc., USA
Gasdermin-D: How to Punch Holes in a Dying Cell

Thursday, February 22 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: British/Columbia Ballroom


Thursday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Columbia Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, February 22 | 8:00PM - 11:00PM
Entertainment
Room: Columbia Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, February 22 | 8:00PM - 11:00PM
Cash Bar
Room: Columbia Ballroom


Friday, February 23 | 10:24AM - 10:24AM
Departure


*Session Chair.