Web Desc
Noncoding RNAs: Form, Function, Physiology
Organizer(s): Joshua T. Mendell, Igor Ulitsky and Sohail F. Tavazoie
Date: February 25 - March 01, 2018
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Ionis Pharmaceuticals, Inc.
Summary of Meeting:
Recent research has revealed pervasive transcription of eukaryotic genomes outside of protein-coding genes. The resulting noncoding RNA transcripts come in many forms, perform diverse functions and play critical roles in organismal health and disease. Tens of thousands of noncoding RNAs have been identified so far, but we are still at the earliest stages of understanding their regulation and function. Such knowledge will be critical in order to harness the full potential of noncoding RNAs for the diagnosis and treatment of human diseases. To address this gap in our understanding, this conference aims to: 1) Bring together a multi-disciplinary group of scientists at all career stages to share their latest research in this field; 2) Provide a forum for the presentation of cutting-edge data on noncoding RNA structure, function and their roles in physiology and disease; and 3) Offer junior scientists outstanding mentoring and networking opportunities through close interactions with senior investigators. It is anticipated that the interactions of participants with diverse backgrounds, expertise and experimental models will spur new lines of investigation and collaborations that will lead to breakthroughs in our understanding of the noncoding transcriptome.
Scholarship Deadline: October 24 2017
Discounted Abstract Deadline: October 24 2017
Abstract Deadline: November 21 2017
Discounted Registration Deadline: December 19 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Ionis Pharmaceuticals, Inc.
We gratefully acknowledge additional support from these exhibitors at this conference:
Arraystar Inc.
We gratefully acknowledge additional support for this conference from:
Integrated DNA TechnologiesOncotarget
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Translate Bio
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 25 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, February 25 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Longs/Quandary Peaks


Monday, February 26 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 1 of 2
* Joshua T. Mendell, University of Texas Southwestern Medical Center, USA

Monday, February 26 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 2 of 2
Caroline Dean, John Innes Centre, UK
Antisense-Mediated Chromatin Silencing at FLC


Monday, February 26 | 9:00AM - 11:15AM
Evolution and Structure of Noncoding RNAs
Room: Grays Peak

Speaker 1 of 6
* Joshua T. Mendell, University of Texas Southwestern Medical Center, USA

Monday, February 26 | 9:00AM - 11:15AM
Evolution and Structure of Noncoding RNAs
Room: Grays Peak

Speaker 2 of 6
Igor Ulitsky, Weizmann Institute of Science, Israel
Sequences Enriched in Alu Repeats Drive Nuclear Localization of Long RNAs in Human Cells

Monday, February 26 | 9:00AM - 11:15AM
Evolution and Structure of Noncoding RNAs
Room: Grays Peak


Coffee Break

Monday, February 26 | 9:00AM - 11:15AM
Evolution and Structure of Noncoding RNAs
Room: Grays Peak

Speaker 4 of 6
Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs


Monday, February 26 | 9:00AM - 11:15AM
Evolution and Structure of Noncoding RNAs
Room: Grays Peak

Speaker 5 of 6
Kevin Weeks, University of North Carolina, USA
Structure-Based Discovery of New Functions in Large RNAs

Monday, February 26 | 9:00AM - 11:15AM
Evolution and Structure of Noncoding RNAs
Room: Grays Peak

Speaker 6 of 6
Yashar Niknafs, University of Michigan, USA
Short Talk: Oncogenic Role of THOR, a Conserved Cancer/Testis Long Noncoding RNA

Monday, February 26 | 11:15AM - 5:00PM
On Own for Lunch


Monday, February 26 | 11:15AM - 1:00PM
Poster Setup
Room: Longs/Quandary Peaks


Monday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs/Quandary Peaks


Monday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 26 | 5:00PM - 7:00PM
Prokaryotic and Viral Noncoding RNAs
Room: Grays Peak

Speaker 1 of 5
* Howard Y. Chang, Stanford University, USA

Monday, February 26 | 5:00PM - 7:00PM
Prokaryotic and Viral Noncoding RNAs
Room: Grays Peak

Speaker 2 of 5
Jörg Vogel, University of Würzburg, Germany
Grad-seq Discovers the Third Domain of
Small RNA-mediated Gene Regulation in Bacteria


Monday, February 26 | 5:00PM - 7:00PM
Prokaryotic and Viral Noncoding RNAs
Room: Grays Peak

Speaker 3 of 5
Ronald R. Breaker, Yale University, USA
Comprehensive Discovery of Ribozymes and Riboswitches

Monday, February 26 | 5:00PM - 7:00PM
Prokaryotic and Viral Noncoding RNAs
Room: Grays Peak

Speaker 4 of 5
Joan A. Steitz, Yale University, USA
Nuclear Noncoding RNAs: More Surprises

Monday, February 26 | 5:00PM - 7:00PM
Prokaryotic and Viral Noncoding RNAs
Room: Grays Peak

Speaker 5 of 5
Roee Amit, Technion - Israel Institute of Technology, Israel
Short Talk: Short CU-Rich Motifs Insulate Bacterial Genes from Transcriptional Read-Through

Monday, February 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks
No registration fees are used to fund alcohol served at this function.

Monday, February 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Longs/Quandary Peaks


Tuesday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Longs/Quandary Peaks


Tuesday, February 27 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetic Regulation
Room: Grays Peak

Speaker 1 of 8
* John L. Rinn, University of Colorado Boulder, USA

Tuesday, February 27 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetic Regulation
Room: Grays Peak

Speaker 2 of 8
Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA
How RNA Recruits Epigenetic Complexes to the X-Chromosome

Tuesday, February 27 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetic Regulation
Room: Grays Peak

Speaker 3 of 8
Neil Brockdorff, University of Oxford, UK
Chromosome Silencing by Xist RNA

Tuesday, February 27 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetic Regulation
Room: Grays Peak


Coffee Break

Tuesday, February 27 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetic Regulation
Room: Grays Peak

Speaker 5 of 8
Roberto Bonasio, University of Pennsylvania, USA
Regulation of Chromatin Complexes by Protein–RNA Interactions

Tuesday, February 27 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetic Regulation
Room: Grays Peak

Speaker 6 of 8
Xiaohua Shen, Tsinghua University, China
Cis-Acting lncRNAs in Transcription and Chromatin Regulation

Tuesday, February 27 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetic Regulation
Room: Grays Peak

Speaker 7 of 8
Chen Davidovich, Monash University, Australia
Short Talk: Mechanism for RNA-Mediated Regulation of the Histone Methyltransferase Polycomb Repressive Complex 2 (PRC2)

Tuesday, February 27 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetic Regulation
Room: Grays Peak

Speaker 8 of 8
Amanda J. Whipple, Harvard University, USA
Short Talk: Neuronal Functions of Imprinted, Noncoding RNAs

Tuesday, February 27 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, February 27 | 11:15AM - 1:00PM
Poster Setup
Room: Longs/Quandary Peaks


Tuesday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs/Quandary Peaks


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop: Highlights of Submitted Abstracts
Room: Longs/Quandary Peaks

Speaker 1 of 10
* Susan B. Carpenter, University of California, Santa Cruz, USA

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop: Highlights of Submitted Abstracts
Room: Longs/Quandary Peaks

Speaker 2 of 10
* David L. Spector, Cold Spring Harbor Laboratory, USA

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop: Highlights of Submitted Abstracts
Room: Longs/Quandary Peaks

Speaker 3 of 10
Amanda Louise Gervaise, Baylor College of Medicine, USA
Global Profiling Identifies Germline miRNAs Functioning During Oogenesis in C. elegans

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop: Highlights of Submitted Abstracts
Room: Longs/Quandary Peaks

Speaker 4 of 10
Yunsun Nam, University of Texas Southwestern Medical Center, USA
Heme Enables Proper Positioning of Drosha and DGCR8 on Primary microRNAs

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop: Highlights of Submitted Abstracts
Room: Longs/Quandary Peaks

Speaker 5 of 10
Yoo Jane Han, University of Chicago, USA
Circular RNAs Expressed from the BRCA1 Pseudogene Regulates the DNA Damage Response through SERBP1 RNA-Binding Protein

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop: Highlights of Submitted Abstracts
Room: Longs/Quandary Peaks

Speaker 6 of 10
Rui Zhou, Johns Hopkins University School of Medicine, USA
The Circular RNA Edis Modulates Innate Immunity and Neurodevelopment in Drosophila

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop: Highlights of Submitted Abstracts
Room: Longs/Quandary Peaks

Speaker 7 of 10
Andre Verdel, Institut Albert Bonniot, France
A New lncRNA-based Mechanism Controlling Sexual Differentiation and Heterochromatin Gene Silencing in Fission Yeast

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop: Highlights of Submitted Abstracts
Room: Longs/Quandary Peaks

Speaker 8 of 10
Martina Rossi, Università degli Studi di Genova, Genoa (UNIGE), Italy
LncRNA EPR Orchestrates Epithelial Gene Expression Program in Mammary Gland Cells

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop: Highlights of Submitted Abstracts
Room: Longs/Quandary Peaks

Speaker 9 of 10
Musaddeque Ahmed, Princess Margaret Cancer Centre, Canada
CRISPRi Screening of Susceptibility Regulatory Regions and Long Noncoding RNAs in Prostate Cancer

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop: Highlights of Submitted Abstracts
Room: Longs/Quandary Peaks

Speaker 10 of 10
Joon H. Choi, University of Texas at Austin, USA
The Triphosphatase DUSP11 Controls the Level and Immunostimulatory Activity of Alu Transcripts

Tuesday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 27 | 5:00PM - 7:00PM
Noncoding RNAs in Subcellular Organization
Room: Grays Peak

Speaker 1 of 5
* Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA

Tuesday, February 27 | 5:00PM - 7:00PM
Noncoding RNAs in Subcellular Organization
Room: Grays Peak

Speaker 2 of 5
Tetsuro Hirose, Osaka University, Japan
Dissection of Elements and Machinery of Architectural Noncoding RNAs


Tuesday, February 27 | 5:00PM - 7:00PM
Noncoding RNAs in Subcellular Organization
Room: Grays Peak

Speaker 3 of 5
David L. Spector, Cold Spring Harbor Laboratory, USA
Targeting Long Noncoding RNAs to Impact Breast Cancer Progression

Tuesday, February 27 | 5:00PM - 7:00PM
Noncoding RNAs in Subcellular Organization
Room: Grays Peak

Speaker 4 of 5
John L. Rinn, University of Colorado Boulder, USA
High-Throughput Identification of RNA Nuclear Enrichment Sequences

Tuesday, February 27 | 5:00PM - 7:00PM
Noncoding RNAs in Subcellular Organization
Room: Grays Peak

Speaker 5 of 5
Miha Modic, Helmholtz Zentrum München, Germany
Short Talk: Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition

Tuesday, February 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks
No registration fees are used to fund alcohol served at this function.

Tuesday, February 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Longs/Quandary Peaks


Wednesday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Longs/Quandary Peaks


Wednesday, February 28 | 8:00AM - 11:15AM
Transcriptional and Post-Transcriptional Regulation by Nonco
ding RNAs

Room: Grays Peak

Speaker 1 of 8
* Matthias W. Hentze, European Molecular Biology Laboratory, Germany

Wednesday, February 28 | 8:00AM - 11:15AM
Transcriptional and Post-Transcriptional Regulation by Nonco
ding RNAs

Room: Grays Peak

Speaker 2 of 8
Reuven Agami, Netherlands Cancer Institute, Netherlands
Transcriptional Control by lncRNAs

Wednesday, February 28 | 8:00AM - 11:15AM
Transcriptional and Post-Transcriptional Regulation by Nonco
ding RNAs

Room: Grays Peak

Speaker 3 of 8
Susan B. Carpenter, University of California, Santa Cruz, USA
Genetic Models Reveal Cis and Trans Functions for LincRNA-Cox2

Wednesday, February 28 | 8:00AM - 11:15AM
Transcriptional and Post-Transcriptional Regulation by Nonco
ding RNAs

Room: Grays Peak


Coffee Break

Wednesday, February 28 | 8:00AM - 11:15AM
Transcriptional and Post-Transcriptional Regulation by Nonco
ding RNAs

Room: Grays Peak

Speaker 5 of 8
Joshua T. Mendell, University of Texas Southwestern Medical Center, USA
Noncoding RNAs in Post-Transcriptional Regulatory Circuits

Wednesday, February 28 | 8:00AM - 11:15AM
Transcriptional and Post-Transcriptional Regulation by Nonco
ding RNAs

Room: Grays Peak

Speaker 6 of 8
Irene Bozzoni, University La Sapienza, Rome, Italy
Long Noncoding RNAs and Circular RNAs in the Control of Muscle Differentiation


Wednesday, February 28 | 8:00AM - 11:15AM
Transcriptional and Post-Transcriptional Regulation by Nonco
ding RNAs

Room: Grays Peak

Speaker 7 of 8
Olof S. Dallner, Rockefeller University, USA
Short Talk: Quantitative Regulation of the Leptin Gene by a Fat-Specific lncRNA

Wednesday, February 28 | 8:00AM - 11:15AM
Transcriptional and Post-Transcriptional Regulation by Nonco
ding RNAs

Room: Grays Peak

Speaker 8 of 8
Ramesh S. Pillai, University of Geneva, Switzerland
Short Talk: Regulation of m6A Transcripts by YTHDC2 Is Essential for Meiosis in the Mammalian Germline

Wednesday, February 28 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, February 28 | 11:15AM - 1:00PM
Poster Setup
Room: Longs/Quandary Peaks


Wednesday, February 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs/Quandary Peaks


Wednesday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 28 | 5:00PM - 7:00PM
Non-Canonical Roles of tRNAs, snoRNAs, and Repetitive RNAs
Room: Grays Peak

Speaker 1 of 5
* Irene Bozzoni, University La Sapienza, Rome, Italy

Wednesday, February 28 | 5:00PM - 7:00PM
Non-Canonical Roles of tRNAs, snoRNAs, and Repetitive RNAs
Room: Grays Peak

Speaker 2 of 5
Sohail F. Tavazoie, Rockefeller University, USA
tRNA Fragments in Hypoxic Response and Cancer Progression

Wednesday, February 28 | 5:00PM - 7:00PM
Non-Canonical Roles of tRNAs, snoRNAs, and Repetitive RNAs
Room: Grays Peak

Speaker 3 of 5
Britt Glaunsinger, University of California, Berkeley and HHMI, USA
Repetitive Noncoding RNAs in Viral Pathogenesis

Wednesday, February 28 | 5:00PM - 7:00PM
Non-Canonical Roles of tRNAs, snoRNAs, and Repetitive RNAs
Room: Grays Peak

Speaker 4 of 5
Matthias W. Hentze, European Molecular Biology Laboratory, Germany
Regulation of Selective Autophagy by the Small Noncoding Vault RNA1-1

Wednesday, February 28 | 5:00PM - 7:00PM
Non-Canonical Roles of tRNAs, snoRNAs, and Repetitive RNAs
Room: Grays Peak

Speaker 5 of 5
Benjamin R. Hawley, Weill Cornell Medicine, USA
Short Talk: Drosha Drives the Formation of DNA:RNA Hybrids around DNA Break Sites to Facilitate DNA Damage Repair

Wednesday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks
No registration fees are used to fund alcohol served at this function.

Wednesday, February 28 | 7:30PM - 10:00PM
Poster Session 3
Room: Longs/Quandary Peaks


Thursday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Longs/Quandary Peaks


Thursday, March 01 | 8:00AM - 11:15AM
Noncoding RNAs in Disease
Room: Grays Peak

Speaker 1 of 8
* Sohail F. Tavazoie, Rockefeller University, USA

Thursday, March 01 | 8:00AM - 11:15AM
Noncoding RNAs in Disease
Room: Grays Peak

Speaker 2 of 8
Stefanie Dimmeler, University of Frankfurt, Germany
Noncoding RNAs in Cardiovascular Diseases

Thursday, March 01 | 8:00AM - 11:15AM
Noncoding RNAs in Disease
Room: Grays Peak

Speaker 3 of 8
Nadya Dimitrova, Yale University, USA
Investigation of Long Noncoding RNAs in Tumorigenesis

Thursday, March 01 | 8:00AM - 11:15AM
Noncoding RNAs in Disease
Room: Grays Peak


Coffee Break

Thursday, March 01 | 8:00AM - 11:15AM
Noncoding RNAs in Disease
Room: Grays Peak

Speaker 5 of 8
Caroline Woo, Translate Bio, USA
Targeting lncRNAs for Gene Upregulation Using Oligonucleotides as a Therapeutic Modality

Thursday, March 01 | 8:00AM - 11:15AM
Noncoding RNAs in Disease
Room: Grays Peak

Speaker 6 of 8
Stefano Gustincich, Italian Institute of Technology, Italy
SINEUPs: A Versatile Tool to Increase Protein Synthesis

Thursday, March 01 | 8:00AM - 11:15AM
Noncoding RNAs in Disease
Room: Grays Peak

Speaker 7 of 8
Ashish Lal, NCI, National Institutes of Health, USA
Short Talk: Regulating the Regulator: Long Noncoding RNAs in the p53 Network in Colorectal Cancer

Thursday, March 01 | 8:00AM - 11:15AM
Noncoding RNAs in Disease
Room: Grays Peak

Speaker 8 of 8
Doug Hanniford, New York University Langone Medical Center, USA
Short Talk: CDR1as Arises from a lncRNA Transcript which Is Epigenetically Silenced to Drive Melanoma Metastasis

Thursday, March 01 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, March 01 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 01 | 5:00PM - 6:45PM
Unconventional RNA Form and Function
Room: Grays Peak

Speaker 1 of 4
* Igor Ulitsky, Weizmann Institute of Science, Israel

Thursday, March 01 | 5:00PM - 6:45PM
Unconventional RNA Form and Function
Room: Grays Peak

Speaker 2 of 4
Jeremy E. Wilusz, University of Pennsylvania, USA
Controlling Circular RNA Levels

Thursday, March 01 | 5:00PM - 6:45PM
Unconventional RNA Form and Function
Room: Grays Peak

Speaker 3 of 4
Ling-Ling Chen, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Biogenesis of Circular RNAs


Thursday, March 01 | 5:00PM - 6:45PM
Unconventional RNA Form and Function
Room: Grays Peak

Speaker 4 of 4
Antonio J. Giraldez, Yale University School of Medicine, USA
Noncoding RNAs and Peptides in Zebrafish Development

Thursday, March 01 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Grays Peak


Thursday, March 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks
No registration fees are used to fund alcohol served at this function.

Thursday, March 01 | 8:00PM - 11:00PM
Entertainment
Room: Longs/Quandary Peaks
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 01 | 8:00PM - 11:00PM
Cash Bar
Room: Longs/Quandary Peaks


Friday, March 02 | 10:24AM - 10:24AM
Departure


*Session Chair.