Web Desc
Cells vs. Pathogens: Intrinsic Defenses and Counterdefenses
Organizer(s): Sara R. Cherry, Craig R. Roy and Harmit S. Malik
Date: March 23 - 26, 2018
Location: Hyatt Regency Monterey, Monterey, CA, USA
Supported by the Directors' Fund
Summary of Meeting:
Cells have evolved complex mechanisms to detect and respond to infection. We are only beginning to uncover the cellular mechanisms that engage invading pathogens to restrict infection. While bacteria, viruses and parasites are seemingly different, emerging data suggests that there is a convergence of cellular pathways that target these invading pathogens, which these pathogens have developed subversive strategies to evade. This conference will focus on host processes at the forefront of this battle and how pathogens are targeted. From the initial stages of non-self-recognition to the effector pathways engaged, these diverse pathogens are both manipulated and manipulating the system. Cutting-edge technologies are driving our deeper understanding of how core biological processes can be regulated in the favor of the host, or pathogen, and how these new mechanisms might be harnessed to treat diverse diseases. This meeting focuses on intrinsic mechanisms of defense across pathogens, bringing together diverse areas of expertise showcasing the convergence of pathways engaged.
Scholarship Deadline: November 21 2017
Discounted Abstract Deadline: November 21 2017
Abstract Deadline: December 19 2017
Discounted Registration Deadline: January 16 2018
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI136565-01
Funding for this conference was made possible (in part) by 1 R13 AI136565-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, March 23 | 4:00PM - 8:00PM
Arrival and Registration
Room: Regency Foyer Terrace


Friday, March 23 | 6:00PM - 8:00PM
Welcome Mixer
Room: Regency Foyer Terrace
No registration fees are used to fund alcohol served at this function.

Saturday, March 24 | 7:30AM - 8:30AM
Breakfast
Room: Regency Grand IV-VI


Saturday, March 24 | 8:00AM - 8:30AM
Poster Setup
Room: Regency Grand IV-VI


Saturday, March 24 | 8:30AM - 5:00PM
Poster Viewing
Room: Regency Grand IV-VI


Saturday, March 24 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Regency Grand I-III

Speaker 1 of 2
* Sara R. Cherry, University of Pennsylvania, USA

Saturday, March 24 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Regency Grand I-III

Speaker 2 of 2
Akiko Iwasaki, HHMI/Yale University School of Medicine, USA
Intrinsic Antiviral Defenses

Saturday, March 24 | 9:30AM - 11:45AM
Cellular Barriers to Infection
Room: Regency Grand I-III

Speaker 1 of 6
* Vera Tarakanova, Medical College of Wisconsin, USA

Saturday, March 24 | 9:30AM - 11:45AM
Cellular Barriers to Infection
Room: Regency Grand I-III

Speaker 2 of 6
Carolyn B. Coyne, University of Pittsburgh, USA
Breaking Barriers – Virus Infection of Polarized Host Cells

Saturday, March 24 | 9:30AM - 11:45AM
Cellular Barriers to Infection
Room: Regency Grand I-III


Coffee Break

Saturday, March 24 | 9:30AM - 11:45AM
Cellular Barriers to Infection
Room: Regency Grand I-III

Speaker 4 of 6
Emily Troemel, University of California, San Diego, USA
C. elegans Barriers to Microsporidia

Saturday, March 24 | 9:30AM - 11:45AM
Cellular Barriers to Infection
Room: Regency Grand I-III

Speaker 5 of 6
Andreas J. Bäumler, University of California, Davis, USA
Healthy Guts Exclude Oxygen

Saturday, March 24 | 9:30AM - 11:45AM
Cellular Barriers to Infection
Room: Regency Grand I-III

Speaker 6 of 6
Molly A. Matty, Duke University, USA
Short Talk: Whole Animal Chemical and Genetic Screens Identify P2RX7 Modulation as a Host-Directed Strategy for Control
of Mycobacterial Infection


Saturday, March 24 | 11:45AM - 12:45PM
Lunch
Room: Regency Grand IV-VI


Saturday, March 24 | 12:00PM - 2:30PM
Poster Session 1
Room: Regency Grand IV-VI


Saturday, March 24 | 2:30PM - 4:30PM
Workshop
Room: Regency Grand I-III

Speaker 1 of 9
* Sara R. Cherry, University of Pennsylvania, USA

Saturday, March 24 | 2:30PM - 4:30PM
Workshop
Room: Regency Grand I-III

Speaker 2 of 9
Kim Davis, Johns Hopkins University, Bloomberg School of Public Health, USA
Subpopulations of Stressed Y. Pseudotuberculosis Have Reduced Antibiotic Susceptibility

Saturday, March 24 | 2:30PM - 4:30PM
Workshop
Room: Regency Grand I-III

Speaker 3 of 9
Aaron E. Lin, Princeton University, USA
Improving Detection of ADAR-Mediated A-to-I Viral RNA Editing using ICE-MaP

Saturday, March 24 | 2:30PM - 4:30PM
Workshop
Room: Regency Grand I-III

Speaker 4 of 9
Stephanie Ragland, University of Virginia, USA
Neisseria Gonorrhoeae Employs Two Protein Inhibitors to Evade Killing by Human Lysozyme

Saturday, March 24 | 2:30PM - 4:30PM
Workshop
Room: Regency Grand I-III

Speaker 5 of 9
Laughing Bear Torrez, Stanford University, USA
CD47 Blockade Reduces Cellular Sequestration and Promotes Survival of Cerebral Malaria

Saturday, March 24 | 2:30PM - 4:30PM
Workshop
Room: Regency Grand I-III

Speaker 6 of 9
Melissa Kane, Rockefeller University, USA
Nuclear Pore Heterogeneity Affects HIV-1 Infection and the Antiviral Activity of Mx2

Saturday, March 24 | 2:30PM - 4:30PM
Workshop
Room: Regency Grand I-III

Speaker 7 of 9
Blake Richardson, University of Texas Southwestern Medical Center, USA
IFI6 is an ER-Localized Antiviral Effector that Requires HSPA5 to Inhibit Flavivirus Replication


Saturday, March 24 | 2:30PM - 4:30PM
Workshop
Room: Regency Grand I-III

Speaker 8 of 9
Emily A. Madden, University of North Carolina at Chapel Hill, USA
RNA Structural Analysis of Chikungunya Virus Identifies 3'UTR Isoforms that Impact Viral Host Range and Replication

Saturday, March 24 | 2:30PM - 4:30PM
Workshop
Room: Regency Grand I-III

Speaker 9 of 9
Michal P. Wandel, MRC Laboratory of Molecular Biology, UK
Interferon-Induced GTPases (GBPs) Attack Shigella flexneri Unless Degraded by the Bacterial Ubiquitin Ligase IpaH9.8

Saturday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Regency Foyer Terrace


Saturday, March 24 | 5:00PM - 7:00PM
Pattern Recognition and Evasion
Room: Regency Grand I-III

Speaker 1 of 5
* John W. Schoggins, University of Texas Southwestern Medical Center, USA

Saturday, March 24 | 5:00PM - 7:00PM
Pattern Recognition and Evasion
Room: Regency Grand I-III

Speaker 2 of 5
Sun Hur, Harvard Medical School, USA
MDA5 – Self vs. Non-Self dsRNA Discrimination

Saturday, March 24 | 5:00PM - 7:00PM
Pattern Recognition and Evasion
Room: Regency Grand I-III

Speaker 3 of 5
John C. Boothroyd, Stanford University School of Medicine, USA
The Challenge of Life in a Bubble: How the Intracellular Parasite, Toxoplasma gondii, Manipulates its Host from Inside a Parasitophorous Vacuole

Saturday, March 24 | 5:00PM - 7:00PM
Pattern Recognition and Evasion
Room: Regency Grand I-III

Speaker 4 of 5
Luciano A. Marraffini, Rockefeller University, USA
Generation of Memory during the CRISPR-Cas Immune Response

Saturday, March 24 | 5:00PM - 7:00PM
Pattern Recognition and Evasion
Room: Regency Grand I-III

Speaker 5 of 5
Holly Ramage, University of Pennsylvania, USA
Short Talk: Using Proteomics Tools to Discover New Mechanisms in Flaviviral Infection

Saturday, March 24 | 7:00PM - 7:00PM
On Own for Dinner


Sunday, March 25 | 7:30AM - 8:30AM
Breakfast
Room: Regency Grand IV-VI


Sunday, March 25 | 8:30AM - 11:30AM
Metabolic Control as a Defense
Room: Regency Grand I-III

Speaker 1 of 7
* Jörn Coers, Duke University, USA

Sunday, March 25 | 8:30AM - 11:30AM
Metabolic Control as a Defense
Room: Regency Grand I-III

Speaker 2 of 7
Nihal Altan-Bonnet, NHLBI, National Institutes of Health, USA
Vesicular Transmission of Viral Populations: Strength in Numbers

Sunday, March 25 | 8:30AM - 11:30AM
Metabolic Control as a Defense
Room: Regency Grand I-III

Speaker 3 of 7
Maayan Levy, University of Pennsylvania, USA
Metabolic Control of Intestinal Epithelial Cell Function

Sunday, March 25 | 8:30AM - 11:30AM
Metabolic Control as a Defense
Room: Regency Grand I-III


Coffee Break

Sunday, March 25 | 8:30AM - 11:30AM
Metabolic Control as a Defense
Room: Regency Grand I-III

Speaker 5 of 7
Ken H. Cadwell, New York University School of Medicine, USA
Autophagy in Resistance versus Tolerance during Infectious Disease

Sunday, March 25 | 8:30AM - 11:30AM
Metabolic Control as a Defense
Room: Regency Grand I-III

Speaker 6 of 7
Russell E. Vance, University of California, Berkeley, USA
Cytosolic Sensing of Bacterial Pathogens

Sunday, March 25 | 8:30AM - 11:30AM
Metabolic Control as a Defense
Room: Regency Grand I-III

Speaker 7 of 7
Ram Savan, University of Washington, USA
Short Talk: Infiltrating Enemy Territory: Host RNA Binding Proteins Localized to Viral Factories

Sunday, March 25 | 11:30AM - 5:00PM
On Own for Lunch


Sunday, March 25 | 11:30AM - 1:00PM
Poster Setup
Room: Regency Grand IV-VI


Sunday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Regency Grand IV-VI


Sunday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Regency Foyer Terrace


Sunday, March 25 | 5:00PM - 7:00PM
Cell Biological Control of Infection through Capture
Room: Regency Grand I-III

Speaker 1 of 5
* Jeffery S. Cox, University of California, Berkeley, USA

Sunday, March 25 | 5:00PM - 7:00PM
Cell Biological Control of Infection through Capture
Room: Regency Grand I-III

Speaker 2 of 5
Craig R. Roy, Yale University School of Medicine, USA
Manipulation of Autophagy by Intracellular Pathogens

Sunday, March 25 | 5:00PM - 7:00PM
Cell Biological Control of Infection through Capture
Room: Regency Grand I-III

Speaker 3 of 5
Ivan Dikic, Goethe University Medical School, Germany
Phosphoribosyl-Dependent Ubiquitination in Regulation of Host-Pathogen Interface

Sunday, March 25 | 5:00PM - 7:00PM
Cell Biological Control of Infection through Capture
Room: Regency Grand I-III

Speaker 4 of 5
Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
A Cell Autonomous Stress Response to Bacterial Viability

Sunday, March 25 | 5:00PM - 7:00PM
Cell Biological Control of Infection through Capture
Room: Regency Grand I-III

Speaker 5 of 5
Scott D. Pegan, University of Georgia, USA
Short Talk: Impact of ISG15 Species-Species Variation on ISG15 Structure and Viral-Host Interactions

Sunday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Regency Grand IV-VI
No registration fees are used to fund alcohol served at this function.

Sunday, March 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Regency Grand IV-VI


Monday, March 26 | 7:30AM - 8:30AM
Breakfast
Room: Regency Grand IV-VI


Monday, March 26 | 8:30AM - 11:30AM
Evolution and Co-Evolution of Intrinsic Defenses
Room: Regency Grand I-III

Speaker 1 of 6
Harmit S. Malik, Fred Hutchinson Cancer Research Center, USA
Using Rapid Evolution to Dissect and Enhance Antiviral Specificity

Monday, March 26 | 8:30AM - 11:30AM
Evolution and Co-Evolution of Intrinsic Defenses
Room: Regency Grand I-III

Speaker 2 of 6
Jörn Coers, Duke University, USA
Antibacterial Host Defense by IFN-Inducible Guanylate Binding Proteins

Monday, March 26 | 8:30AM - 11:30AM
Evolution and Co-Evolution of Intrinsic Defenses
Room: Regency Grand I-III


Coffee Break

Monday, March 26 | 8:30AM - 11:30AM
Evolution and Co-Evolution of Intrinsic Defenses
Room: Regency Grand I-III

Speaker 4 of 6
Alan G. Goodman, Washington State University, USA
Conservation of Host-Pathogen Interactions and Innate Immunity in Insects and Mammals

Monday, March 26 | 8:30AM - 11:30AM
Evolution and Co-Evolution of Intrinsic Defenses
Room: Regency Grand I-III

Speaker 5 of 6
Paul E. Turner, Yale University, USA
Using Phage to Select for Evolution of Reduced Virulence in Pathogenic Bacteria

Monday, March 26 | 8:30AM - 11:30AM
Evolution and Co-Evolution of Intrinsic Defenses
Room: Regency Grand I-III

Speaker 6 of 6
* Tamara O'Connor, Johns Hopkins School of Medicine, USA
Short Talk: The Evolution of a Human Bacterial Pathogen from the Combined Selective Pressures of Multiple Environmental Hosts

Monday, March 26 | 11:30AM - 5:00PM
On Own for Lunch


Monday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Regency Foyer Terrace


Monday, March 26 | 5:00PM - 6:45PM
Systems Approaches to Discover Intrinsic Effectors
Room: Regency Grand I-III

Speaker 1 of 3
* Holly Ramage, University of Pennsylvania, USA

Monday, March 26 | 5:00PM - 6:45PM
Systems Approaches to Discover Intrinsic Effectors
Room: Regency Grand I-III

Speaker 2 of 3
Sara R. Cherry, University of Pennsylvania, USA
Using Functional Genomics to Explore Arbovirus-Host Interactions

Monday, March 26 | 5:00PM - 6:45PM
Systems Approaches to Discover Intrinsic Effectors
Room: Regency Grand I-III

Speaker 3 of 3
Nels C. Elde, University of Utah, USA
Interim Immune Functions

Monday, March 26 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Regency Grand I-III


Monday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Regency Grand IV-VI
No registration fees are used to fund alcohol served at this function.

Monday, March 26 | 8:00PM - 11:00PM
Entertainment
Room: Regency Grand IV-VI
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Monday, March 26 | 8:00PM - 11:00PM
Cash Bar
Room: Regency Grand IV-VI


Tuesday, March 27 | 10:24AM - 10:24AM
Departure


*Session Chair.