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Web Desc
Cells vs. Pathogens: Intrinsic Defenses and Counterdefenses Organizer(s): Sara R. Cherry, Craig R. Roy and Harmit S. Malik Date: March 23 - 26, 2018 Location: Hyatt Regency Monterey, Monterey, CA, USA Supported by the Directors' Fund Summary of Meeting: Cells have evolved complex mechanisms to detect and respond to infection. We are only beginning to uncover the cellular mechanisms that engage invading pathogens to restrict infection. While bacteria, viruses and parasites are seemingly different, emerging data suggests that there is a convergence of cellular pathways that target these invading pathogens, which these pathogens have developed subversive strategies to evade. This conference will focus on host processes at the forefront of this battle and how pathogens are targeted. From the initial stages of non-self-recognition to the effector pathways engaged, these diverse pathogens are both manipulated and manipulating the system. Cutting-edge technologies are driving our deeper understanding of how core biological processes can be regulated in the favor of the host, or pathogen, and how these new mechanisms might be harnessed to treat diverse diseases. This meeting focuses on intrinsic mechanisms of defense across pathogens, bringing together diverse areas of expertise showcasing the convergence of pathways engaged. Scholarship Deadline: November 21 2017 Discounted Abstract Deadline: November 21 2017 Abstract Deadline: December 19 2017 Discounted Registration Deadline: January 16 2018 We gratefully acknowledge the generous grant for this conference provided by: National Institute of Allergy and Infectious Diseases (NIAID) Grant No. 1 R13 AI136565-01 Funding for this conference was made possible (in part) by 1 R13 AI136565-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Cells vs. Pathogens: Intrinsic Defenses and Counterdefenses

Organizer(s): Sara R. Cherry, Craig R. Roy and Harmit S. Malik

Date: March 23 - 26, 2018
Location: Hyatt Regency Monterey, Monterey, CA, USA

Supported by the Directors' Fund

Summary of Meeting:

Cells have evolved complex mechanisms to detect and respond to infection. We are only beginning to uncover the cellular mechanisms that engage invading pathogens to restrict infection. While bacteria, viruses and parasites are seemingly different, emerging data suggests that there is a convergence of cellular pathways that target these invading pathogens, which these pathogens have developed subversive strategies to evade. This conference will focus on host processes at the forefront of this battle and how pathogens are targeted. From the initial stages of non-self-recognition to the effector pathways engaged, these diverse pathogens are both manipulated and manipulating the system. Cutting-edge technologies are driving our deeper understanding of how core biological processes can be regulated in the favor of the host, or pathogen, and how these new mechanisms might be harnessed to treat diverse diseases. This meeting focuses on intrinsic mechanisms of defense across pathogens, bringing together diverse areas of expertise showcasing the convergence of pathways engaged.

Scholarship Deadline: November 21 2017

Discounted Abstract Deadline: November 21 2017

Abstract Deadline: December 19 2017

Discounted Registration Deadline: January 16 2018

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI136565-01
Funding for this conference was made possible (in part) by 1 R13 AI136565-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Friday, March 23 \| 4:00PM - 8:00PM Arrival and Registration Room: Regency Foyer Terrace
Friday, March 23 \| 6:00PM - 8:00PM Welcome Mixer Room: Regency Foyer Terrace No registration fees are used to fund alcohol served at this function.
Saturday, March 24 \| 7:30AM - 8:30AM Breakfast Room: Regency Grand IV-VI
Saturday, March 24 \| 8:00AM - 8:30AM Poster Setup Room: Regency Grand IV-VI
Saturday, March 24 \| 8:30AM - 5:00PM Poster Viewing Room: Regency Grand IV-VI
Saturday, March 24 \| 8:30AM - 9:30AM Welcome and Keynote Address Room: Regency Grand I-III Speaker 1 of 2 * Sara R. Cherry, University of Pennsylvania, USA
Saturday, March 24 \| 8:30AM - 9:30AM Welcome and Keynote Address Room: Regency Grand I-III Speaker 2 of 2 Akiko Iwasaki, HHMI/Yale University School of Medicine, USA Intrinsic Antiviral Defenses
Saturday, March 24 \| 9:30AM - 11:45AM Cellular Barriers to Infection Room: Regency Grand I-III Speaker 1 of 6 * Vera Tarakanova, Medical College of Wisconsin, USA
Saturday, March 24 \| 9:30AM - 11:45AM Cellular Barriers to Infection Room: Regency Grand I-III Speaker 2 of 6 Carolyn B. Coyne, University of Pittsburgh, USA Breaking Barriers – Virus Infection of Polarized Host Cells
Saturday, March 24 \| 9:30AM - 11:45AM Cellular Barriers to Infection Room: Regency Grand I-III Coffee Break
Saturday, March 24 \| 9:30AM - 11:45AM Cellular Barriers to Infection Room: Regency Grand I-III Speaker 4 of 6 Emily Troemel, University of California, San Diego, USA C. elegans Barriers to Microsporidia
Saturday, March 24 \| 9:30AM - 11:45AM Cellular Barriers to Infection Room: Regency Grand I-III Speaker 5 of 6 Andreas J. Bäumler, University of California, Davis, USA Healthy Guts Exclude Oxygen
Saturday, March 24 \| 9:30AM - 11:45AM Cellular Barriers to Infection Room: Regency Grand I-III Speaker 6 of 6 Molly A. Matty, Duke University, USA Short Talk: Whole Animal Chemical and Genetic Screens Identify P2RX7 Modulation as a Host-Directed Strategy for Control of Mycobacterial Infection
Saturday, March 24 \| 11:45AM - 12:45PM Lunch Room: Regency Grand IV-VI
Saturday, March 24 \| 12:00PM - 2:30PM Poster Session 1 Room: Regency Grand IV-VI
Saturday, March 24 \| 2:30PM - 4:30PM Workshop Room: Regency Grand I-III Speaker 1 of 9 * Sara R. Cherry, University of Pennsylvania, USA
Saturday, March 24 \| 2:30PM - 4:30PM Workshop Room: Regency Grand I-III Speaker 2 of 9 Kim Davis, Johns Hopkins University, Bloomberg School of Public Health, USA Subpopulations of Stressed Y. Pseudotuberculosis Have Reduced Antibiotic Susceptibility
Saturday, March 24 \| 2:30PM - 4:30PM Workshop Room: Regency Grand I-III Speaker 3 of 9 Aaron E. Lin, Princeton University, USA Improving Detection of ADAR-Mediated A-to-I Viral RNA Editing using ICE-MaP
Saturday, March 24 \| 2:30PM - 4:30PM Workshop Room: Regency Grand I-III Speaker 4 of 9 Stephanie Ragland, University of Virginia, USA Neisseria Gonorrhoeae Employs Two Protein Inhibitors to Evade Killing by Human Lysozyme
Saturday, March 24 \| 2:30PM - 4:30PM Workshop Room: Regency Grand I-III Speaker 5 of 9 Laughing Bear Torrez, Stanford University, USA CD47 Blockade Reduces Cellular Sequestration and Promotes Survival of Cerebral Malaria
Saturday, March 24 \| 2:30PM - 4:30PM Workshop Room: Regency Grand I-III Speaker 6 of 9 Melissa Kane, Rockefeller University, USA Nuclear Pore Heterogeneity Affects HIV-1 Infection and the Antiviral Activity of Mx2
Saturday, March 24 \| 2:30PM - 4:30PM Workshop Room: Regency Grand I-III Speaker 7 of 9 Blake Richardson, University of Texas Southwestern Medical Center, USA IFI6 is an ER-Localized Antiviral Effector that Requires HSPA5 to Inhibit Flavivirus Replication
Saturday, March 24 \| 2:30PM - 4:30PM Workshop Room: Regency Grand I-III Speaker 8 of 9 Emily A. Madden, University of North Carolina at Chapel Hill, USA RNA Structural Analysis of Chikungunya Virus Identifies 3'UTR Isoforms that Impact Viral Host Range and Replication
Saturday, March 24 \| 2:30PM - 4:30PM Workshop Room: Regency Grand I-III Speaker 9 of 9 Michal P. Wandel, MRC Laboratory of Molecular Biology, UK Interferon-Induced GTPases (GBPs) Attack Shigella flexneri Unless Degraded by the Bacterial Ubiquitin Ligase IpaH9.8
Saturday, March 24 \| 4:30PM - 5:00PM Coffee Available Room: Regency Foyer Terrace
Saturday, March 24 \| 5:00PM - 7:00PM Pattern Recognition and Evasion Room: Regency Grand I-III Speaker 1 of 5 * John W. Schoggins, University of Texas Southwestern Medical Center, USA
Saturday, March 24 \| 5:00PM - 7:00PM Pattern Recognition and Evasion Room: Regency Grand I-III Speaker 2 of 5 Sun Hur, Harvard Medical School, USA MDA5 – Self vs. Non-Self dsRNA Discrimination
Saturday, March 24 \| 5:00PM - 7:00PM Pattern Recognition and Evasion Room: Regency Grand I-III Speaker 3 of 5 John C. Boothroyd, Stanford University School of Medicine, USA The Challenge of Life in a Bubble: How the Intracellular Parasite, Toxoplasma gondii, Manipulates its Host from Inside a Parasitophorous Vacuole
Saturday, March 24 \| 5:00PM - 7:00PM Pattern Recognition and Evasion Room: Regency Grand I-III Speaker 4 of 5 Luciano A. Marraffini, Rockefeller University, USA Generation of Memory during the CRISPR-Cas Immune Response
Saturday, March 24 \| 5:00PM - 7:00PM Pattern Recognition and Evasion Room: Regency Grand I-III Speaker 5 of 5 Holly Ramage, University of Pennsylvania, USA Short Talk: Using Proteomics Tools to Discover New Mechanisms in Flaviviral Infection
Saturday, March 24 \| 7:00PM - 7:00PM On Own for Dinner
Sunday, March 25 \| 7:30AM - 8:30AM Breakfast Room: Regency Grand IV-VI
Sunday, March 25 \| 8:30AM - 11:30AM Metabolic Control as a Defense Room: Regency Grand I-III Speaker 1 of 7 * Jörn Coers, Duke University, USA
Sunday, March 25 \| 8:30AM - 11:30AM Metabolic Control as a Defense Room: Regency Grand I-III Speaker 2 of 7 Nihal Altan-Bonnet, NHLBI, National Institutes of Health, USA Vesicular Transmission of Viral Populations: Strength in Numbers
Sunday, March 25 \| 8:30AM - 11:30AM Metabolic Control as a Defense Room: Regency Grand I-III Speaker 3 of 7 Maayan Levy, University of Pennsylvania, USA Metabolic Control of Intestinal Epithelial Cell Function
Sunday, March 25 \| 8:30AM - 11:30AM Metabolic Control as a Defense Room: Regency Grand I-III Coffee Break
Sunday, March 25 \| 8:30AM - 11:30AM Metabolic Control as a Defense Room: Regency Grand I-III Speaker 5 of 7 Ken H. Cadwell, New York University School of Medicine, USA Autophagy in Resistance versus Tolerance during Infectious Disease
Sunday, March 25 \| 8:30AM - 11:30AM Metabolic Control as a Defense Room: Regency Grand I-III Speaker 6 of 7 Russell E. Vance, University of California, Berkeley, USA Cytosolic Sensing of Bacterial Pathogens
Sunday, March 25 \| 8:30AM - 11:30AM Metabolic Control as a Defense Room: Regency Grand I-III Speaker 7 of 7 Ram Savan, University of Washington, USA Short Talk: Infiltrating Enemy Territory: Host RNA Binding Proteins Localized to Viral Factories
Sunday, March 25 \| 11:30AM - 5:00PM On Own for Lunch
Sunday, March 25 \| 11:30AM - 1:00PM Poster Setup Room: Regency Grand IV-VI
Sunday, March 25 \| 1:00PM - 10:00PM Poster Viewing Room: Regency Grand IV-VI
Sunday, March 25 \| 4:30PM - 5:00PM Coffee Available Room: Regency Foyer Terrace
Sunday, March 25 \| 5:00PM - 7:00PM Cell Biological Control of Infection through Capture Room: Regency Grand I-III Speaker 1 of 5 * Jeffery S. Cox, University of California, Berkeley, USA
Sunday, March 25 \| 5:00PM - 7:00PM Cell Biological Control of Infection through Capture Room: Regency Grand I-III Speaker 2 of 5 Craig R. Roy, Yale University School of Medicine, USA Manipulation of Autophagy by Intracellular Pathogens
Sunday, March 25 \| 5:00PM - 7:00PM Cell Biological Control of Infection through Capture Room: Regency Grand I-III Speaker 3 of 5 Ivan Dikic, Goethe University Medical School, Germany Phosphoribosyl-Dependent Ubiquitination in Regulation of Host-Pathogen Interface
Sunday, March 25 \| 5:00PM - 7:00PM Cell Biological Control of Infection through Capture Room: Regency Grand I-III Speaker 4 of 5 Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA A Cell Autonomous Stress Response to Bacterial Viability
Sunday, March 25 \| 5:00PM - 7:00PM Cell Biological Control of Infection through Capture Room: Regency Grand I-III Speaker 5 of 5 Scott D. Pegan, University of Georgia, USA Short Talk: Impact of ISG15 Species-Species Variation on ISG15 Structure and Viral-Host Interactions
Sunday, March 25 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Regency Grand IV-VI No registration fees are used to fund alcohol served at this function.
Sunday, March 25 \| 7:30PM - 10:00PM Poster Session 2 Room: Regency Grand IV-VI
Monday, March 26 \| 7:30AM - 8:30AM Breakfast Room: Regency Grand IV-VI
Monday, March 26 \| 8:30AM - 11:30AM Evolution and Co-Evolution of Intrinsic Defenses Room: Regency Grand I-III Speaker 1 of 6 Harmit S. Malik, Fred Hutchinson Cancer Research Center, USA Using Rapid Evolution to Dissect and Enhance Antiviral Specificity
Monday, March 26 \| 8:30AM - 11:30AM Evolution and Co-Evolution of Intrinsic Defenses Room: Regency Grand I-III Speaker 2 of 6 Jörn Coers, Duke University, USA Antibacterial Host Defense by IFN-Inducible Guanylate Binding Proteins
Monday, March 26 \| 8:30AM - 11:30AM Evolution and Co-Evolution of Intrinsic Defenses Room: Regency Grand I-III Coffee Break
Monday, March 26 \| 8:30AM - 11:30AM Evolution and Co-Evolution of Intrinsic Defenses Room: Regency Grand I-III Speaker 4 of 6 Alan G. Goodman, Washington State University, USA Conservation of Host-Pathogen Interactions and Innate Immunity in Insects and Mammals
Monday, March 26 \| 8:30AM - 11:30AM Evolution and Co-Evolution of Intrinsic Defenses Room: Regency Grand I-III Speaker 5 of 6 Paul E. Turner, Yale University, USA Using Phage to Select for Evolution of Reduced Virulence in Pathogenic Bacteria
Monday, March 26 \| 8:30AM - 11:30AM Evolution and Co-Evolution of Intrinsic Defenses Room: Regency Grand I-III Speaker 6 of 6 * Tamara O'Connor, Johns Hopkins School of Medicine, USA Short Talk: The Evolution of a Human Bacterial Pathogen from the Combined Selective Pressures of Multiple Environmental Hosts
Monday, March 26 \| 11:30AM - 5:00PM On Own for Lunch
Monday, March 26 \| 4:30PM - 5:00PM Coffee Available Room: Regency Foyer Terrace
Monday, March 26 \| 5:00PM - 6:45PM Systems Approaches to Discover Intrinsic Effectors Room: Regency Grand I-III Speaker 1 of 3 * Holly Ramage, University of Pennsylvania, USA
Monday, March 26 \| 5:00PM - 6:45PM Systems Approaches to Discover Intrinsic Effectors Room: Regency Grand I-III Speaker 2 of 3 Sara R. Cherry, University of Pennsylvania, USA Using Functional Genomics to Explore Arbovirus-Host Interactions
Monday, March 26 \| 5:00PM - 6:45PM Systems Approaches to Discover Intrinsic Effectors Room: Regency Grand I-III Speaker 3 of 3 Nels C. Elde, University of Utah, USA Interim Immune Functions
Monday, March 26 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Regency Grand I-III
Monday, March 26 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Regency Grand IV-VI No registration fees are used to fund alcohol served at this function.
Monday, March 26 \| 8:00PM - 11:00PM Entertainment Room: Regency Grand IV-VI Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Monday, March 26 \| 8:00PM - 11:00PM Cash Bar Room: Regency Grand IV-VI
Tuesday, March 27 \| 10:24AM - 10:24AM Departure *Session Chair.