Web Desc
Pushing the Limits of Healthspan and Longevity
Organizer(s): Rochelle Buffenstein, Holly Brown-Borg and Colin Selman
Date: April 15 - 19, 2018
Location: Herrenhausen Palace, Hannover, Germany
Local Co-Organizer: Martin S. Denzel, Max Planck Institute for Biology of Aging.
Organized in collaboration with Volkswagen Foundation
For important information on the coronavirus, please click here
Summary of Meeting:
This conference addresses factors that may contribute to healthier lifestyles and outcomes, thereby delaying the onset of age-associated diseases and extending longevity. The focus is to highlight cutting-edge advances in aging research, novel technologies and potential therapeutic interventions. Included are talks on mechanisms of aging in a wide range of established and non-traditional animal models with the key objective to enhance understanding of the basic biology behind experimental and lifestyle manipulations thought to have direct translational application to human aging. The conference will focus on topics not covered at previous Keystone Symposia meetings on aging biology and will specifically examine both the fundamental mechanisms involved in the aging process as well as interventions and potential therapeutics that may delay aging and the onset of age-associated diseases to forge a deeper understanding of the complex, multifactorial aging process. The discussions of novel interventions and/or therapeutics that appear to slow aging processes will, in turn, guide the field toward facilitating extended periods of good health and prolonging lifespan in humans.
Scholarship Deadline: December 12 2017
Discounted Abstract Deadline: December 12 2017
Abstract Deadline: January 10 2018
Discounted Registration Deadline: February 13 2018
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


We gratefully acknowledge additional support for this conference from:
Aging CellZymo Research Corporation
Keystone Symposia thanks the Volkswagen Foundation for hosting this conference:
in Cooperation with Volkswagen Foundation
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 15 | 4:00PM - 8:00PM
Arrival and Registration
Room: Grand Mussmann Hotel, Tivoli Room


Sunday, April 15 | 6:00PM - 8:00PM
Welcome Mixer
Room: Central-Hotel Kaiserhof
No registration fees are used to fund alcohol served at this function.

Monday, April 16 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Auditorium

Speaker 1 of 2
* Rochelle Buffenstein, Calico Life Sciences LLC, USA

Monday, April 16 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Auditorium

Speaker 2 of 2
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Controlling Metabolism during Aging, Role of Insulin and Adipose Depots

Monday, April 16 | 9:30AM - 12:00PM
Communicating to Save Thyself: Is a Single Signaling Path th
e Answer?

Room: Auditorium

Speaker 1 of 7
* Rochelle Buffenstein, Calico Life Sciences LLC, USA

Monday, April 16 | 9:30AM - 12:00PM
Communicating to Save Thyself: Is a Single Signaling Path th
e Answer?

Room: Auditorium

Speaker 2 of 7
Holly M. Brown-Borg, University of North Dakota School of Medicine, USA
Growth Hormone Signaling and Longevity

Monday, April 16 | 9:30AM - 12:00PM
Communicating to Save Thyself: Is a Single Signaling Path th
e Answer?

Room: Auditorium


Coffee Break

Monday, April 16 | 9:30AM - 12:00PM
Communicating to Save Thyself: Is a Single Signaling Path th
e Answer?

Room: Auditorium

Speaker 4 of 7
Dana L. Miller, University of Washington, USA
Fasting Protects against Hypoxia-Induced Protein Aggregation by Inducing Non-Canonical Insulin Signaling

Monday, April 16 | 9:30AM - 12:00PM
Communicating to Save Thyself: Is a Single Signaling Path th
e Answer?

Room: Auditorium

Speaker 5 of 7
Reinhold G. Erben, University of Veterinary Medicine Vienna, Austria
Role of the Klotho/FGF23 Signaling Axis in Aging

Monday, April 16 | 9:30AM - 12:00PM
Communicating to Save Thyself: Is a Single Signaling Path th
e Answer?

Room: Auditorium

Speaker 6 of 7
Paul L. Fox, Lerner Research Institute, USA
Short Talk: Glutamyl-Prolyl tRNA Synthetase Is a Critical mTORC1-S6K1 Target Determining Adiposity and Lifespan in Mice

Monday, April 16 | 9:30AM - 12:00PM
Communicating to Save Thyself: Is a Single Signaling Path th
e Answer?

Room: Auditorium

Speaker 7 of 7
Christopher G. Proud, South Australian Health & Medical Research Institute, Australia
Short Talk: Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Lifespan

Monday, April 16 | 12:00PM - 1:00PM
Lunch
Room: Ballroom


Monday, April 16 | 12:30PM - 1:00PM
Poster Setup
Room: Ballroom


Monday, April 16 | 1:00PM - 7:30PM
Poster Viewing
Room: Ballroom


Monday, April 16 | 1:00PM - 3:30PM
Poster Session 1
Room: Ballroom


Monday, April 16 | 3:30PM - 4:00PM
Coffee Available
Room: Foyer


Monday, April 16 | 4:00PM - 6:15PM
Good Fat, Bad Fat, Brown Fat, White Fat….
Room: Auditorium

Speaker 1 of 5
* Colin Selman, University of Glasgow, UK

Monday, April 16 | 4:00PM - 6:15PM
Good Fat, Bad Fat, Brown Fat, White Fat….
Room: Auditorium

Speaker 2 of 5
Elisabetta Mueller, New York University, USA
Transcriptional Control of Adipocyte Function in Aging

Monday, April 16 | 4:00PM - 6:15PM
Good Fat, Bad Fat, Brown Fat, White Fat….
Room: Auditorium

Speaker 3 of 5
Barbara Cannon, Stockholm University, Sweden
Environmental Temperature and Longevity

Monday, April 16 | 4:00PM - 6:15PM
Good Fat, Bad Fat, Brown Fat, White Fat….
Room: Auditorium

Speaker 4 of 5
John Speakman, Institute of Genetics and Developmental Biology, CAS, China
Does Dietary Protein Content Leverage Total Food Intake and Hence Drive Obesity?

Monday, April 16 | 4:00PM - 6:15PM
Good Fat, Bad Fat, Brown Fat, White Fat….
Room: Auditorium

Speaker 5 of 5
Susanne Klaus, German Institute of Human Nutrition, Germany
Mitochondrial Uncoupling, Diet, and Aging in Mice

Monday, April 16 | 6:15PM - 7:30PM
Dinner
Room: Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, April 17 | 8:30AM - 11:45AM
Trash Removal: Is Enhanced Proteostasis the Way Forward in A
ging

Room: Auditorium

Speaker 1 of 8
* David Gems, University College London, UK

Tuesday, April 17 | 8:30AM - 11:45AM
Trash Removal: Is Enhanced Proteostasis the Way Forward in A
ging

Room: Auditorium

Speaker 2 of 8
Rochelle Buffenstein, Calico Life Sciences LLC, USA
Extreme Longevity in Naked Mole-Rats Is Associated with Upregulated Proteostasis

Tuesday, April 17 | 8:30AM - 11:45AM
Trash Removal: Is Enhanced Proteostasis the Way Forward in A
ging

Room: Auditorium

Speaker 3 of 8
Martin S. Denzel, Max Planck Institute for Biology of Aging, Germany
Forward Genetic Approaches Reveal Multi-Layered Regulation of the Hexosamine Pathway that Modulates Protein Quality Control

Tuesday, April 17 | 8:30AM - 11:45AM
Trash Removal: Is Enhanced Proteostasis the Way Forward in A
ging

Room: Auditorium


Coffee Break

Tuesday, April 17 | 8:30AM - 11:45AM
Trash Removal: Is Enhanced Proteostasis the Way Forward in A
ging

Room: Auditorium

Speaker 5 of 8
Karyn L. Hamilton, Colorado State University, USA
Contribution of Changes in Cell Proliferation to Proteostasis in Long-Lived Models

Tuesday, April 17 | 8:30AM - 11:45AM
Trash Removal: Is Enhanced Proteostasis the Way Forward in A
ging

Room: Auditorium

Speaker 6 of 8
Louis R. Lapierre, Brown University, USA
A Novel and Druggable Modulator of HLH-30/TFEB, Autophagy and Lifespan

Tuesday, April 17 | 8:30AM - 11:45AM
Trash Removal: Is Enhanced Proteostasis the Way Forward in A
ging

Room: Auditorium

Speaker 7 of 8
Fabian Finger, University of Cologne, Germany
Short Talk: Food Perception through a Pair of Olfactory Neurons Triggers Rewiring of Organismal Proteostasis

Tuesday, April 17 | 8:30AM - 11:45AM
Trash Removal: Is Enhanced Proteostasis the Way Forward in A
ging

Room: Auditorium

Speaker 8 of 8
Mario Ost, German Institute of Human Nutrition, Germany
Short Talk: Elevated FGF21 during Aging Is Required to Preserve Hepatic Proteostasis and Metabolic Health

Tuesday, April 17 | 11:45AM - 1:00PM
Lunch
Room: Ballroom


Tuesday, April 17 | 12:30PM - 1:00PM
Poster Setup
Room: Ballroom


Tuesday, April 17 | 1:00PM - 7:30PM
Poster Viewing
Room: Ballroom


Tuesday, April 17 | 1:00PM - 3:30PM
Poster Session 2
Room: Ballroom


Tuesday, April 17 | 3:30PM - 4:00PM
Coffee Available
Room: Foyer


Tuesday, April 17 | 4:00PM - 6:00PM
Powerhouse of the Cell: Manipulating Energy in Aging
Room: Auditorium

Speaker 1 of 5
* Barbara Cannon, Stockholm University, Sweden

Tuesday, April 17 | 4:00PM - 6:00PM
Powerhouse of the Cell: Manipulating Energy in Aging
Room: Auditorium

Speaker 2 of 5
William B. Mair, Harvard School of Public Health, USA
Mitochondrial Dynamics and Healthy Aging

Tuesday, April 17 | 4:00PM - 6:00PM
Powerhouse of the Cell: Manipulating Energy in Aging
Room: Auditorium

Speaker 3 of 5
Hazel H. Szeto, Social Profit Network Research Laboratory, USA
Novel Peptides Target Cellular Powerhouses to Delay Aging and Mitigate Age-Related Chronic Conditions

Tuesday, April 17 | 4:00PM - 6:00PM
Powerhouse of the Cell: Manipulating Energy in Aging
Room: Auditorium

Speaker 4 of 5
Fernanda Marques da Cunha, Federal University of São Paulo, Brazil
Short Talk: Mitochondrial Effects of Lifespan-Extending Interventions in Caenorhabditis elegans

Tuesday, April 17 | 4:00PM - 6:00PM
Powerhouse of the Cell: Manipulating Energy in Aging
Room: Auditorium

Speaker 5 of 5
Jan Nedergaard, Stockholm University, Sweden
Short Talk: Enhanced ROS Production in Mitochondria from Prematurely Aging mtDNA Mutator Mice

Tuesday, April 17 | 6:00PM - 7:30PM
Social Hour with Lite Bites
Room: Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, April 18 | 8:30AM - 11:30AM
Changing What and How We Eat and its Impact upon Healthspan
Room: Auditorium

Speaker 1 of 7
* Holly M. Brown-Borg, University of North Dakota School of Medicine, USA

Wednesday, April 18 | 8:30AM - 11:30AM
Changing What and How We Eat and its Impact upon Healthspan
Room: Auditorium

Speaker 2 of 7
Colin Selman, University of Glasgow, UK
The Influence of Genetic Background on the Metabolic Responsiveness to Dietary Restriction in Mice

Wednesday, April 18 | 8:30AM - 11:30AM
Changing What and How We Eat and its Impact upon Healthspan
Room: Auditorium

Speaker 3 of 7
Matthew Piper, Monash University, Australia
The Role of Amino Acid Balance in Lifespan and Health in Drosophila

Wednesday, April 18 | 8:30AM - 11:30AM
Changing What and How We Eat and its Impact upon Healthspan
Room: Auditorium


Coffee Break

Wednesday, April 18 | 8:30AM - 11:30AM
Changing What and How We Eat and its Impact upon Healthspan
Room: Auditorium

Speaker 5 of 7
Samantha Marie Biet, University of Sydney, Australia
Extending Healthspan and Lifespan: Insights From Nutritional Geometry

Wednesday, April 18 | 8:30AM - 11:30AM
Changing What and How We Eat and its Impact upon Healthspan
Room: Auditorium

Speaker 6 of 7
Olga Spadaro, Yale University, USA
Short Talk: Caloric Restriction in Humans Inhibits Inflammation: Insights from CALERIE-II

Wednesday, April 18 | 8:30AM - 11:30AM
Changing What and How We Eat and its Impact upon Healthspan
Room: Auditorium

Speaker 7 of 7
YongTian Liang, Free University of Berlin & Charité, Germany
Short Talk: Spermidine and Dietary Restriction Converging on Mitochondrial Metabolism in a Model of Cognitive Aging

Wednesday, April 18 | 11:30AM - 1:00PM
Lunch
Room: Ballroom


Wednesday, April 18 | 12:30PM - 1:00PM
Poster Setup
Room: Ballroom


Wednesday, April 18 | 1:00PM - 7:30PM
Poster Viewing
Room: Ballroom


Wednesday, April 18 | 1:00PM - 3:30PM
Poster Session 3
Room: Ballroom


Wednesday, April 18 | 3:30PM - 4:00PM
Coffee Available
Room: Foyer


Wednesday, April 18 | 4:00PM - 6:00PM
Swords, Targets and Cell Death: Combatting Senescence
Room: Auditorium

Speaker 1 of 5
* Martin S. Denzel, Max Planck Institute for Biology of Aging, Germany

Wednesday, April 18 | 4:00PM - 6:00PM
Swords, Targets and Cell Death: Combatting Senescence
Room: Auditorium

Speaker 2 of 5
Judith Campisi, Buck Institute for Research on Aging, USA
Cellular Senescence: A Double-Edged Sword

Wednesday, April 18 | 4:00PM - 6:00PM
Swords, Targets and Cell Death: Combatting Senescence
Room: Auditorium

Speaker 3 of 5
Manlio Vinciguerra, International Clinical Research Center, Czech Republic
Epigenetic Links between Senescence and Cancer Stemness

Wednesday, April 18 | 4:00PM - 6:00PM
Swords, Targets and Cell Death: Combatting Senescence
Room: Auditorium

Speaker 4 of 5
Nathan K. LeBrasseur, Mayo Clinic, USA
Senolytic Mechanism to Extend Healthspan

Wednesday, April 18 | 4:00PM - 6:00PM
Swords, Targets and Cell Death: Combatting Senescence
Room: Auditorium

Speaker 5 of 5
Anil Bhushan, University of California, San Francisco, USA
Short Talk: Eliminating Senescent Beta Cells Prevents Type 1 Diabetes

Wednesday, April 18 | 6:00PM - 7:30PM
Dinner
Room: Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, April 19 | 8:30AM - 11:45AM
A View from Above: Aging at the Top of the Food Chain
Room: Auditorium

Speaker 1 of 8
* Susanne Klaus, German Institute of Human Nutrition, Germany

Thursday, April 19 | 8:30AM - 11:45AM
A View from Above: Aging at the Top of the Food Chain
Room: Auditorium

Speaker 2 of 8
Riikka Hamalainen, University of Eastern Finland, Finland
Mitochondrial DNA Mutagenesis and Aging

Thursday, April 19 | 8:30AM - 11:45AM
A View from Above: Aging at the Top of the Food Chain
Room: Auditorium

Speaker 3 of 8
P. Eline Slagboom, Leiden University, Netherlands
Three Generations of Human Top Survivors: What Have We Learned

Thursday, April 19 | 8:30AM - 11:45AM
A View from Above: Aging at the Top of the Food Chain
Room: Auditorium


Coffee Break

Thursday, April 19 | 8:30AM - 11:45AM
A View from Above: Aging at the Top of the Food Chain
Room: Auditorium

Speaker 5 of 8
Maiken Nedergaard, University of Rochester, USA
The Gymphatic System

Thursday, April 19 | 8:30AM - 11:45AM
A View from Above: Aging at the Top of the Food Chain
Room: Auditorium

Speaker 6 of 8
Alexander Bürkle, University of Konstanz, Germany
Biomarkers of Human Aging – The EU FP7 MARK-AGE Project and Beyond

Thursday, April 19 | 8:30AM - 11:45AM
A View from Above: Aging at the Top of the Food Chain
Room: Auditorium

Speaker 7 of 8
Pénélope Andreux, Amazentis, Switzerland
Short Talk: Orally Administered Urolithin A Is Safe and Modulates Muscle and Mitochondrial Biomarkers in Elderly

Thursday, April 19 | 8:30AM - 11:45AM
A View from Above: Aging at the Top of the Food Chain
Room: Auditorium

Speaker 8 of 8
Ian R. Lanza, Mayo Clinic College of Medicine, USA
Short Talk: Therapeutic Potential of Dietary Omega-3 Fatty Acids in Aging Skeletal Muscle

Thursday, April 19 | 11:45AM - 1:30PM
Lunch
Room: Ballroom


Thursday, April 19 | 1:30PM - 3:30PM
Workshop
Room: Auditorium

Speaker 1 of 9
* Karyn L. Hamilton, Colorado State University, USA

Thursday, April 19 | 1:30PM - 3:30PM
Workshop
Room: Auditorium

Speaker 2 of 9
David A. Ferenbach, University of Edinburgh, UK
The Impact of a Young Circulation on Renal Injury and Fibrosis in Aged Mice

Thursday, April 19 | 1:30PM - 3:30PM
Workshop
Room: Auditorium

Speaker 3 of 9
Zoe E. Gillespie, University of Saskatchewan, Canada
Metformin Treatment and Amino Acid Restriction Induce Progerin Degradation in Hutchinson-Gilford Progeria Syndrome Fibroblasts

Thursday, April 19 | 1:30PM - 3:30PM
Workshop
Room: Auditorium

Speaker 4 of 9
Samir Morsli, University of Sheffield, UK
Establishing a Model of Stress-Induced Senescence in Zebrafish Larvae

Thursday, April 19 | 1:30PM - 3:30PM
Workshop
Room: Auditorium

Speaker 5 of 9
Teresa G. Valencak, University of Veterinary Medicine, Vienna, Austria
Becoming Obese and Hyperthermic en Miniature in Ames Dwarf Mice (Prop1 df/df)

Thursday, April 19 | 1:30PM - 3:30PM
Workshop
Room: Auditorium

Speaker 6 of 9
Reza Esmaillie, University of Cologne, Germany
Dissecting the Role of Hypoxia-Signaling in Extracellular Matrix Formation of the Nematode

Thursday, April 19 | 1:30PM - 3:30PM
Workshop
Room: Auditorium

Speaker 7 of 9
Johannes Grillari, BOKU - University of Natural Resources and Applied Life Sciences Vienna, Austria
Extracellular Vesicles and their miRNA Cargo in Aging and Age-Associated Diseases

Thursday, April 19 | 1:30PM - 3:30PM
Workshop
Room: Auditorium

Speaker 8 of 9
Irina G. Shabalina, Stockholm University, Sweden
Upregulated Cytochrome b5 May Rescue Normal Androgen Production in Mitochondrial Respiratory Chain Deficient Leydig Cells from Prematurely Aging Mice

Thursday, April 19 | 1:30PM - 3:30PM
Workshop
Room: Auditorium

Speaker 9 of 9
Asael Roichman, Bar Ilan University, Israel
SIRT6 Controls Energy Metabolism to Regulate Lifespan and Healthspan

Thursday, April 19 | 3:30PM - 4:00PM
Coffee Available
Room: Foyer


Thursday, April 19 | 4:00PM - 5:45PM
Drugging Aging - Interventions to Extend Human Health and Li
fespan

Room: Auditorium

Speaker 1 of 4
* Nathan K. LeBrasseur, Mayo Clinic, USA

Thursday, April 19 | 4:00PM - 5:45PM
Drugging Aging - Interventions to Extend Human Health and Li
fespan

Room: Auditorium

Speaker 2 of 4
Andrew Phillips, C4 Therapeutics, USA
Targeted Protein Degradation

Thursday, April 19 | 4:00PM - 5:45PM
Drugging Aging - Interventions to Extend Human Health and Li
fespan

Room: Auditorium

Speaker 3 of 4
David Gems, University College London, UK
What Is an Anti-Aging Drug?

Thursday, April 19 | 4:00PM - 5:45PM
Drugging Aging - Interventions to Extend Human Health and Li
fespan

Room: Auditorium

Speaker 4 of 4
Pedro J. Beltran, UNITY Biotechnology, USA
Senolytic Drugs: From Mutant Mice to Human Clinical Trials

Thursday, April 19 | 5:45PM - 6:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Ballroom


Thursday, April 19 | 6:00PM - 7:30PM
Dinner
Room: Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, April 19 | 7:00PM - 10:00PM
Entertainment
Room: Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Friday, April 20 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.