Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Cancer: Aging in the Driver's Seat (2022C4)
Intra- and Intercellular Mechanisms of Aging (2020B2)
Mitochondria in Aging and Age-Related Disease (2019J2)

Web Desc
Pushing the Limits of Healthspan and Longevity Organizer(s): Rochelle Buffenstein, Holly Brown-Borg and Colin Selman Date: April 15 - 19, 2018 Location: Herrenhausen Palace, Hannover, Germany Local Co-Organizer: Martin S. Denzel, Max Planck Institute for Biology of Aging. Organized in collaboration with Volkswagen Foundation For important information on the coronavirus, please click here Summary of Meeting: This conference addresses factors that may contribute to healthier lifestyles and outcomes, thereby delaying the onset of age-associated diseases and extending longevity. The focus is to highlight cutting-edge advances in aging research, novel technologies and potential therapeutic interventions. Included are talks on mechanisms of aging in a wide range of established and non-traditional animal models with the key objective to enhance understanding of the basic biology behind experimental and lifestyle manipulations thought to have direct translational application to human aging. The conference will focus on topics not covered at previous Keystone Symposia meetings on aging biology and will specifically examine both the fundamental mechanisms involved in the aging process as well as interventions and potential therapeutics that may delay aging and the onset of age-associated diseases to forge a deeper understanding of the complex, multifactorial aging process. The discussions of novel interventions and/or therapeutics that appear to slow aging processes will, in turn, guide the field toward facilitating extended periods of good health and prolonging lifespan in humans. Scholarship Deadline: December 12 2017 Discounted Abstract Deadline: December 12 2017 Abstract Deadline: January 10 2018 Discounted Registration Deadline: February 13 2018 Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested. We gratefully acknowledge additional support for this conference from: Keystone Symposia thanks the Volkswagen Foundation for hosting this conference: We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Pushing the Limits of Healthspan and Longevity

Organizer(s): Rochelle Buffenstein, Holly Brown-Borg and Colin Selman

Date: April 15 - 19, 2018
Location: Herrenhausen Palace, Hannover, Germany

Local Co-Organizer: Martin S. Denzel, Max Planck Institute for Biology of Aging.
Organized in collaboration with Volkswagen Foundation

For important information on the coronavirus, please click here

Summary of Meeting:

This conference addresses factors that may contribute to healthier lifestyles and outcomes, thereby delaying the onset of age-associated diseases and extending longevity. The focus is to highlight cutting-edge advances in aging research, novel technologies and potential therapeutic interventions. Included are talks on mechanisms of aging in a wide range of established and non-traditional animal models with the key objective to enhance understanding of the basic biology behind experimental and lifestyle manipulations thought to have direct translational application to human aging. The conference will focus on topics not covered at previous Keystone Symposia meetings on aging biology and will specifically examine both the fundamental mechanisms involved in the aging process as well as interventions and potential therapeutics that may delay aging and the onset of age-associated diseases to forge a deeper understanding of the complex, multifactorial aging process. The discussions of novel interventions and/or therapeutics that appear to slow aging processes will, in turn, guide the field toward facilitating extended periods of good health and prolonging lifespan in humans.

Scholarship Deadline: December 12 2017

Discounted Abstract Deadline: December 12 2017

Abstract Deadline: January 10 2018

Discounted Registration Deadline: February 13 2018

Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.

We gratefully acknowledge additional support for this conference from:

Keystone Symposia thanks the Volkswagen Foundation for hosting this conference:

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, April 15 \| 4:00PM - 8:00PM Arrival and Registration Room: Grand Mussmann Hotel, Tivoli Room
Sunday, April 15 \| 6:00PM - 8:00PM Welcome Mixer Room: Central-Hotel Kaiserhof No registration fees are used to fund alcohol served at this function.
Monday, April 16 \| 8:30AM - 9:30AM Welcome and Keynote Address Room: Auditorium Speaker 1 of 2 * Rochelle Buffenstein, Calico Life Sciences LLC, USA
Monday, April 16 \| 8:30AM - 9:30AM Welcome and Keynote Address Room: Auditorium Speaker 2 of 2 C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA Controlling Metabolism during Aging, Role of Insulin and Adipose Depots
Monday, April 16 \| 9:30AM - 12:00PM Communicating to Save Thyself: Is a Single Signaling Path th e Answer? Room: Auditorium Speaker 1 of 7 * Rochelle Buffenstein, Calico Life Sciences LLC, USA
Monday, April 16 \| 9:30AM - 12:00PM Communicating to Save Thyself: Is a Single Signaling Path th e Answer? Room: Auditorium Speaker 2 of 7 Holly M. Brown-Borg, University of North Dakota School of Medicine, USA Growth Hormone Signaling and Longevity
Monday, April 16 \| 9:30AM - 12:00PM Communicating to Save Thyself: Is a Single Signaling Path th e Answer? Room: Auditorium Coffee Break
Monday, April 16 \| 9:30AM - 12:00PM Communicating to Save Thyself: Is a Single Signaling Path th e Answer? Room: Auditorium Speaker 4 of 7 Dana L. Miller, University of Washington, USA Fasting Protects against Hypoxia-Induced Protein Aggregation by Inducing Non-Canonical Insulin Signaling
Monday, April 16 \| 9:30AM - 12:00PM Communicating to Save Thyself: Is a Single Signaling Path th e Answer? Room: Auditorium Speaker 5 of 7 Reinhold G. Erben, University of Veterinary Medicine Vienna, Austria Role of the Klotho/FGF23 Signaling Axis in Aging
Monday, April 16 \| 9:30AM - 12:00PM Communicating to Save Thyself: Is a Single Signaling Path th e Answer? Room: Auditorium Speaker 6 of 7 Paul L. Fox, Lerner Research Institute, USA Short Talk: Glutamyl-Prolyl tRNA Synthetase Is a Critical mTORC1-S6K1 Target Determining Adiposity and Lifespan in Mice
Monday, April 16 \| 9:30AM - 12:00PM Communicating to Save Thyself: Is a Single Signaling Path th e Answer? Room: Auditorium Speaker 7 of 7 Christopher G. Proud, South Australian Health & Medical Research Institute, Australia Short Talk: Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Lifespan
Monday, April 16 \| 12:00PM - 1:00PM Lunch Room: Ballroom
Monday, April 16 \| 12:30PM - 1:00PM Poster Setup Room: Ballroom
Monday, April 16 \| 1:00PM - 7:30PM Poster Viewing Room: Ballroom
Monday, April 16 \| 1:00PM - 3:30PM Poster Session 1 Room: Ballroom
Monday, April 16 \| 3:30PM - 4:00PM Coffee Available Room: Foyer
Monday, April 16 \| 4:00PM - 6:15PM Good Fat, Bad Fat, Brown Fat, White Fat…. Room: Auditorium Speaker 1 of 5 * Colin Selman, University of Glasgow, UK
Monday, April 16 \| 4:00PM - 6:15PM Good Fat, Bad Fat, Brown Fat, White Fat…. Room: Auditorium Speaker 2 of 5 Elisabetta Mueller, New York University, USA Transcriptional Control of Adipocyte Function in Aging
Monday, April 16 \| 4:00PM - 6:15PM Good Fat, Bad Fat, Brown Fat, White Fat…. Room: Auditorium Speaker 3 of 5 Barbara Cannon, Stockholm University, Sweden Environmental Temperature and Longevity
Monday, April 16 \| 4:00PM - 6:15PM Good Fat, Bad Fat, Brown Fat, White Fat…. Room: Auditorium Speaker 4 of 5 John Speakman, Institute of Genetics and Developmental Biology, CAS, China Does Dietary Protein Content Leverage Total Food Intake and Hence Drive Obesity?
Monday, April 16 \| 4:00PM - 6:15PM Good Fat, Bad Fat, Brown Fat, White Fat…. Room: Auditorium Speaker 5 of 5 Susanne Klaus, German Institute of Human Nutrition, Germany Mitochondrial Uncoupling, Diet, and Aging in Mice
Monday, April 16 \| 6:15PM - 7:30PM Dinner Room: Ballroom No registration fees are used to fund alcohol served at this function.
Tuesday, April 17 \| 8:30AM - 11:45AM Trash Removal: Is Enhanced Proteostasis the Way Forward in A ging Room: Auditorium Speaker 1 of 8 * David Gems, University College London, UK
Tuesday, April 17 \| 8:30AM - 11:45AM Trash Removal: Is Enhanced Proteostasis the Way Forward in A ging Room: Auditorium Speaker 2 of 8 Rochelle Buffenstein, Calico Life Sciences LLC, USA Extreme Longevity in Naked Mole-Rats Is Associated with Upregulated Proteostasis
Tuesday, April 17 \| 8:30AM - 11:45AM Trash Removal: Is Enhanced Proteostasis the Way Forward in A ging Room: Auditorium Speaker 3 of 8 Martin S. Denzel, Max Planck Institute for Biology of Aging, Germany Forward Genetic Approaches Reveal Multi-Layered Regulation of the Hexosamine Pathway that Modulates Protein Quality Control
Tuesday, April 17 \| 8:30AM - 11:45AM Trash Removal: Is Enhanced Proteostasis the Way Forward in A ging Room: Auditorium Coffee Break
Tuesday, April 17 \| 8:30AM - 11:45AM Trash Removal: Is Enhanced Proteostasis the Way Forward in A ging Room: Auditorium Speaker 5 of 8 Karyn L. Hamilton, Colorado State University, USA Contribution of Changes in Cell Proliferation to Proteostasis in Long-Lived Models
Tuesday, April 17 \| 8:30AM - 11:45AM Trash Removal: Is Enhanced Proteostasis the Way Forward in A ging Room: Auditorium Speaker 6 of 8 Louis R. Lapierre, Brown University, USA A Novel and Druggable Modulator of HLH-30/TFEB, Autophagy and Lifespan
Tuesday, April 17 \| 8:30AM - 11:45AM Trash Removal: Is Enhanced Proteostasis the Way Forward in A ging Room: Auditorium Speaker 7 of 8 Fabian Finger, University of Cologne, Germany Short Talk: Food Perception through a Pair of Olfactory Neurons Triggers Rewiring of Organismal Proteostasis
Tuesday, April 17 \| 8:30AM - 11:45AM Trash Removal: Is Enhanced Proteostasis the Way Forward in A ging Room: Auditorium Speaker 8 of 8 Mario Ost, German Institute of Human Nutrition, Germany Short Talk: Elevated FGF21 during Aging Is Required to Preserve Hepatic Proteostasis and Metabolic Health
Tuesday, April 17 \| 11:45AM - 1:00PM Lunch Room: Ballroom
Tuesday, April 17 \| 12:30PM - 1:00PM Poster Setup Room: Ballroom
Tuesday, April 17 \| 1:00PM - 7:30PM Poster Viewing Room: Ballroom
Tuesday, April 17 \| 1:00PM - 3:30PM Poster Session 2 Room: Ballroom
Tuesday, April 17 \| 3:30PM - 4:00PM Coffee Available Room: Foyer
Tuesday, April 17 \| 4:00PM - 6:00PM Powerhouse of the Cell: Manipulating Energy in Aging Room: Auditorium Speaker 1 of 5 * Barbara Cannon, Stockholm University, Sweden
Tuesday, April 17 \| 4:00PM - 6:00PM Powerhouse of the Cell: Manipulating Energy in Aging Room: Auditorium Speaker 2 of 5 William B. Mair, Harvard School of Public Health, USA Mitochondrial Dynamics and Healthy Aging
Tuesday, April 17 \| 4:00PM - 6:00PM Powerhouse of the Cell: Manipulating Energy in Aging Room: Auditorium Speaker 3 of 5 Hazel H. Szeto, Social Profit Network Research Laboratory, USA Novel Peptides Target Cellular Powerhouses to Delay Aging and Mitigate Age-Related Chronic Conditions
Tuesday, April 17 \| 4:00PM - 6:00PM Powerhouse of the Cell: Manipulating Energy in Aging Room: Auditorium Speaker 4 of 5 Fernanda Marques da Cunha, Federal University of São Paulo, Brazil Short Talk: Mitochondrial Effects of Lifespan-Extending Interventions in Caenorhabditis elegans
Tuesday, April 17 \| 4:00PM - 6:00PM Powerhouse of the Cell: Manipulating Energy in Aging Room: Auditorium Speaker 5 of 5 Jan Nedergaard, Stockholm University, Sweden Short Talk: Enhanced ROS Production in Mitochondria from Prematurely Aging mtDNA Mutator Mice
Tuesday, April 17 \| 6:00PM - 7:30PM Social Hour with Lite Bites Room: Ballroom No registration fees are used to fund alcohol served at this function.
Wednesday, April 18 \| 8:30AM - 11:30AM Changing What and How We Eat and its Impact upon Healthspan Room: Auditorium Speaker 1 of 7 * Holly M. Brown-Borg, University of North Dakota School of Medicine, USA
Wednesday, April 18 \| 8:30AM - 11:30AM Changing What and How We Eat and its Impact upon Healthspan Room: Auditorium Speaker 2 of 7 Colin Selman, University of Glasgow, UK The Influence of Genetic Background on the Metabolic Responsiveness to Dietary Restriction in Mice
Wednesday, April 18 \| 8:30AM - 11:30AM Changing What and How We Eat and its Impact upon Healthspan Room: Auditorium Speaker 3 of 7 Matthew Piper, Monash University, Australia The Role of Amino Acid Balance in Lifespan and Health in Drosophila
Wednesday, April 18 \| 8:30AM - 11:30AM Changing What and How We Eat and its Impact upon Healthspan Room: Auditorium Coffee Break
Wednesday, April 18 \| 8:30AM - 11:30AM Changing What and How We Eat and its Impact upon Healthspan Room: Auditorium Speaker 5 of 7 Samantha Marie Biet, University of Sydney, Australia Extending Healthspan and Lifespan: Insights From Nutritional Geometry
Wednesday, April 18 \| 8:30AM - 11:30AM Changing What and How We Eat and its Impact upon Healthspan Room: Auditorium Speaker 6 of 7 Olga Spadaro, Yale University, USA Short Talk: Caloric Restriction in Humans Inhibits Inflammation: Insights from CALERIE-II
Wednesday, April 18 \| 8:30AM - 11:30AM Changing What and How We Eat and its Impact upon Healthspan Room: Auditorium Speaker 7 of 7 YongTian Liang, Free University of Berlin & Charité, Germany Short Talk: Spermidine and Dietary Restriction Converging on Mitochondrial Metabolism in a Model of Cognitive Aging
Wednesday, April 18 \| 11:30AM - 1:00PM Lunch Room: Ballroom
Wednesday, April 18 \| 12:30PM - 1:00PM Poster Setup Room: Ballroom
Wednesday, April 18 \| 1:00PM - 7:30PM Poster Viewing Room: Ballroom
Wednesday, April 18 \| 1:00PM - 3:30PM Poster Session 3 Room: Ballroom
Wednesday, April 18 \| 3:30PM - 4:00PM Coffee Available Room: Foyer
Wednesday, April 18 \| 4:00PM - 6:00PM Swords, Targets and Cell Death: Combatting Senescence Room: Auditorium Speaker 1 of 5 * Martin S. Denzel, Max Planck Institute for Biology of Aging, Germany
Wednesday, April 18 \| 4:00PM - 6:00PM Swords, Targets and Cell Death: Combatting Senescence Room: Auditorium Speaker 2 of 5 Judith Campisi, Buck Institute for Research on Aging, USA Cellular Senescence: A Double-Edged Sword
Wednesday, April 18 \| 4:00PM - 6:00PM Swords, Targets and Cell Death: Combatting Senescence Room: Auditorium Speaker 3 of 5 Manlio Vinciguerra, International Clinical Research Center, Czech Republic Epigenetic Links between Senescence and Cancer Stemness
Wednesday, April 18 \| 4:00PM - 6:00PM Swords, Targets and Cell Death: Combatting Senescence Room: Auditorium Speaker 4 of 5 Nathan K. LeBrasseur, Mayo Clinic, USA Senolytic Mechanism to Extend Healthspan
Wednesday, April 18 \| 4:00PM - 6:00PM Swords, Targets and Cell Death: Combatting Senescence Room: Auditorium Speaker 5 of 5 Anil Bhushan, University of California, San Francisco, USA Short Talk: Eliminating Senescent Beta Cells Prevents Type 1 Diabetes
Wednesday, April 18 \| 6:00PM - 7:30PM Dinner Room: Ballroom No registration fees are used to fund alcohol served at this function.
Thursday, April 19 \| 8:30AM - 11:45AM A View from Above: Aging at the Top of the Food Chain Room: Auditorium Speaker 1 of 8 * Susanne Klaus, German Institute of Human Nutrition, Germany
Thursday, April 19 \| 8:30AM - 11:45AM A View from Above: Aging at the Top of the Food Chain Room: Auditorium Speaker 2 of 8 Riikka Hamalainen, University of Eastern Finland, Finland Mitochondrial DNA Mutagenesis and Aging
Thursday, April 19 \| 8:30AM - 11:45AM A View from Above: Aging at the Top of the Food Chain Room: Auditorium Speaker 3 of 8 P. Eline Slagboom, Leiden University, Netherlands Three Generations of Human Top Survivors: What Have We Learned
Thursday, April 19 \| 8:30AM - 11:45AM A View from Above: Aging at the Top of the Food Chain Room: Auditorium Coffee Break
Thursday, April 19 \| 8:30AM - 11:45AM A View from Above: Aging at the Top of the Food Chain Room: Auditorium Speaker 5 of 8 Maiken Nedergaard, University of Rochester, USA The Gymphatic System
Thursday, April 19 \| 8:30AM - 11:45AM A View from Above: Aging at the Top of the Food Chain Room: Auditorium Speaker 6 of 8 Alexander Bürkle, University of Konstanz, Germany Biomarkers of Human Aging – The EU FP7 MARK-AGE Project and Beyond
Thursday, April 19 \| 8:30AM - 11:45AM A View from Above: Aging at the Top of the Food Chain Room: Auditorium Speaker 7 of 8 Pénélope Andreux, Amazentis, Switzerland Short Talk: Orally Administered Urolithin A Is Safe and Modulates Muscle and Mitochondrial Biomarkers in Elderly
Thursday, April 19 \| 8:30AM - 11:45AM A View from Above: Aging at the Top of the Food Chain Room: Auditorium Speaker 8 of 8 Ian R. Lanza, Mayo Clinic College of Medicine, USA Short Talk: Therapeutic Potential of Dietary Omega-3 Fatty Acids in Aging Skeletal Muscle
Thursday, April 19 \| 11:45AM - 1:30PM Lunch Room: Ballroom
Thursday, April 19 \| 1:30PM - 3:30PM Workshop Room: Auditorium Speaker 1 of 9 * Karyn L. Hamilton, Colorado State University, USA
Thursday, April 19 \| 1:30PM - 3:30PM Workshop Room: Auditorium Speaker 2 of 9 David A. Ferenbach, University of Edinburgh, UK The Impact of a Young Circulation on Renal Injury and Fibrosis in Aged Mice
Thursday, April 19 \| 1:30PM - 3:30PM Workshop Room: Auditorium Speaker 3 of 9 Zoe E. Gillespie, University of Saskatchewan, Canada Metformin Treatment and Amino Acid Restriction Induce Progerin Degradation in Hutchinson-Gilford Progeria Syndrome Fibroblasts
Thursday, April 19 \| 1:30PM - 3:30PM Workshop Room: Auditorium Speaker 4 of 9 Samir Morsli, University of Sheffield, UK Establishing a Model of Stress-Induced Senescence in Zebrafish Larvae
Thursday, April 19 \| 1:30PM - 3:30PM Workshop Room: Auditorium Speaker 5 of 9 Teresa G. Valencak, University of Veterinary Medicine, Vienna, Austria Becoming Obese and Hyperthermic en Miniature in Ames Dwarf Mice (Prop1 df/df)
Thursday, April 19 \| 1:30PM - 3:30PM Workshop Room: Auditorium Speaker 6 of 9 Reza Esmaillie, University of Cologne, Germany Dissecting the Role of Hypoxia-Signaling in Extracellular Matrix Formation of the Nematode
Thursday, April 19 \| 1:30PM - 3:30PM Workshop Room: Auditorium Speaker 7 of 9 Johannes Grillari, BOKU - University of Natural Resources and Applied Life Sciences Vienna, Austria Extracellular Vesicles and their miRNA Cargo in Aging and Age-Associated Diseases
Thursday, April 19 \| 1:30PM - 3:30PM Workshop Room: Auditorium Speaker 8 of 9 Irina G. Shabalina, Stockholm University, Sweden Upregulated Cytochrome b5 May Rescue Normal Androgen Production in Mitochondrial Respiratory Chain Deficient Leydig Cells from Prematurely Aging Mice
Thursday, April 19 \| 1:30PM - 3:30PM Workshop Room: Auditorium Speaker 9 of 9 Asael Roichman, Bar Ilan University, Israel SIRT6 Controls Energy Metabolism to Regulate Lifespan and Healthspan
Thursday, April 19 \| 3:30PM - 4:00PM Coffee Available Room: Foyer
Thursday, April 19 \| 4:00PM - 5:45PM Drugging Aging - Interventions to Extend Human Health and Li fespan Room: Auditorium Speaker 1 of 4 * Nathan K. LeBrasseur, Mayo Clinic, USA
Thursday, April 19 \| 4:00PM - 5:45PM Drugging Aging - Interventions to Extend Human Health and Li fespan Room: Auditorium Speaker 2 of 4 Andrew Phillips, C4 Therapeutics, USA Targeted Protein Degradation
Thursday, April 19 \| 4:00PM - 5:45PM Drugging Aging - Interventions to Extend Human Health and Li fespan Room: Auditorium Speaker 3 of 4 David Gems, University College London, UK What Is an Anti-Aging Drug?
Thursday, April 19 \| 4:00PM - 5:45PM Drugging Aging - Interventions to Extend Human Health and Li fespan Room: Auditorium Speaker 4 of 4 Pedro J. Beltran, UNITY Biotechnology, USA Senolytic Drugs: From Mutant Mice to Human Clinical Trials
Thursday, April 19 \| 5:45PM - 6:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Ballroom
Thursday, April 19 \| 6:00PM - 7:30PM Dinner Room: Ballroom No registration fees are used to fund alcohol served at this function.
Thursday, April 19 \| 7:00PM - 10:00PM Entertainment Room: Ballroom Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Friday, April 20 \| 10:24AM - 10:24AM Departure *Session Chair †Invited, not yet responded.