Web Desc
Exosomes/Microvesicles: Heterogeneity, Biogenesis, Function and Therapeutic Developments
Organizer(s): Crislyn D'Souza-Schorey and David Lyden
Date: June 04 - 08, 2018
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by Directors' Fund
Summary of Meeting:
Extracellular vesicles (EVs) have emerged as critical mediators of intercellular communication in both local and distant microenvironments, during normal development and physiological processes, as well as in orchestrating systemic pathophysiological events. EVs comprise a large group of heterogeneous particles, including exosomes and microvesicles, and are released from virtually all cell types. Differing in size, macromolecular composition, and mechanism of formation, subpopulations of extracellular vesicles contain biologically active molecules, such as nucleic acids (DNA, mRNA, microRNA and other noncoding RNAs), proteins (transmembrane receptors, transcription factors, enzymes, extracellular matrix proteins), and lipids that can in part or in sum contribute to the functional capabilities of the vesicle itself, or the reprogramming of target cells that interact with EVs. This complexity presents significant challenges to determining the functional roles of the various EV populations during both normal and pathological processes. Conference sessions will focus on EV cargo and composition; the role of EVs in development; EV-mediated immune regulation; EVs in cancer and metastasis, neurodegeneration and infectious disease; emerging technologies; and harnessing the therapeutic potential of EVs. The overall goal is to deepen our understanding of the structural and functional complexity of extracellular vesicles, their biogenesis and function in health and disease, cargo enrichment, potential as ideal biomarkers, and breakthroughs in their use as therapeutic targets/agents.
Scholarship Deadline: February 6 2018
Discounted Abstract Deadline: February 6 2018
Abstract Deadline: March 6 2018
Discounted Registration Deadline: April 10 2018
We gratefully acknowledge additional support from these exhibitors at this conference:
Izon ScienceNanoView Biosciences Inc.The Paul G. Allen Frontiers Group
We gratefully acknowledge additional support for this conference from:
University of Notre Dame
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA228495-01
Funding for this conference was made possible (in part) by 1R13CA228495-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, June 04 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Monday, June 04 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Tuesday, June 05 | 7:30AM - 8:30AM
Breakfast
Room: Summit Gallery


Tuesday, June 05 | 8:00AM - 8:30AM
Poster Setup
Room: Breckenridge Ballroom


Tuesday, June 05 | 8:30AM - 5:00PM
Poster Viewing
Room: Breckenridge Ballroom


Tuesday, June 05 | 8:30AM - 11:45AM
EV Cargo and Delivery
Room: Colorado Ballroom

Speaker 1 of 7
* Xandra O. Breakefield, Massachusetts General Hospital, USA
Functional Delivery by EVs

Tuesday, June 05 | 8:30AM - 11:45AM
EV Cargo and Delivery
Room: Colorado Ballroom

Speaker 2 of 7
Dolores Di Vizio, Cedars-Sinai Medical Center, USA
Oncosomes in Prostate Cancer

Tuesday, June 05 | 8:30AM - 11:45AM
EV Cargo and Delivery
Room: Colorado Ballroom

Speaker 3 of 7
Bruno Costa-Silva, Champalimaud Foundation, Portugal
Population Analysis of Exosomes

Tuesday, June 05 | 8:30AM - 11:45AM
EV Cargo and Delivery
Room: Colorado Ballroom


Coffee Break

Tuesday, June 05 | 8:30AM - 11:45AM
EV Cargo and Delivery
Room: Colorado Ballroom

Speaker 5 of 7
James Clancy, University of Notre Dame, USA
Regulated Cargo Delivery to Tumor Microvesicles: How Do Cells Put their Messages in a Bottle?

Tuesday, June 05 | 8:30AM - 11:45AM
EV Cargo and Delivery
Room: Colorado Ballroom

Speaker 6 of 7
Andrew M. Leidal, University of California, San Francisco, USA
Short Talk: The Autophagy Conjugation Machinery Specifies the Loading of RNA-Binding Proteins into Extracellular
Microvesicles


Tuesday, June 05 | 8:30AM - 11:45AM
EV Cargo and Delivery
Room: Colorado Ballroom

Speaker 7 of 7
Michael Hantak, Loyola University Stritch School of Medicine, USA
Short Talk: Enhancers and Suppressors of EV - Mediated Intercellular Cargo Transfer

Tuesday, June 05 | 11:45AM - 12:30PM
Lunch
Room: Breckenridge Ballroom


Tuesday, June 05 | 12:00PM - 2:30PM
Poster Session 1
Room: Breckenridge Ballroom


Tuesday, June 05 | 2:30PM - 4:30PM
Panel: Meet the Editors
Room: Colorado Ballroom

Speaker 1 of 7
* David Lyden, Weill Cornell Medical College, USA

Tuesday, June 05 | 2:30PM - 4:30PM
Panel: Meet the Editors
Room: Colorado Ballroom

Speaker 2 of 7
Gemma Kathleen Alderton, Science Magazine, UK

Tuesday, June 05 | 2:30PM - 4:30PM
Panel: Meet the Editors
Room: Colorado Ballroom

Speaker 3 of 7
Alexia-Ileana Zaromytidou, Nature Cancer, USA

Tuesday, June 05 | 2:30PM - 4:30PM
Panel: Meet the Editors
Room: Colorado Ballroom

Speaker 4 of 7
Simona Fiorani, Nature Communications, UK

Tuesday, June 05 | 2:30PM - 4:30PM
Panel: Meet the Editors
Room: Colorado Ballroom

Speaker 5 of 7
Elisabetta Argenzio, EMBO Journal, Germany

Tuesday, June 05 | 2:30PM - 4:30PM
Panel: Meet the Editors
Room: Colorado Ballroom

Speaker 6 of 7
Petra Gross, Journal of Cell Science, UK

Tuesday, June 05 | 2:30PM - 4:30PM
Panel: Meet the Editors
Room: Colorado Ballroom

Speaker 7 of 7
Masha Gelfand, Cell Press, USA

Tuesday, June 05 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, June 05 | 5:00PM - 7:15PM
EVs and Regulation of the Immune Response
Room: Colorado Ballroom

Speaker 1 of 5
* Marca H.M. Wauben, Universiteit Utrecht, Netherlands
Cross-Organism Communication: The Immune Regulatory Role of Breast Milk Extracellular Vesicles

Tuesday, June 05 | 5:00PM - 7:15PM
EVs and Regulation of the Immune Response
Room: Colorado Ballroom

Speaker 2 of 5
Susanne Gabrielsson, Karolinska Institutet, Sweden
Potentiating Immune Responses to Exosomes for Cancer Therapy

Tuesday, June 05 | 5:00PM - 7:15PM
EVs and Regulation of the Immune Response
Room: Colorado Ballroom

Speaker 3 of 5
Olga V. Volpert, University of Texas MD Anderson Cancer Center, USA
The Dichotomy of the Innate Immune Response to Cancer Exosomes

Tuesday, June 05 | 5:00PM - 7:15PM
EVs and Regulation of the Immune Response
Room: Colorado Ballroom

Speaker 4 of 5
Simon Heidegger, Klinikum Rechts der Isar, Technical University Munich, Germany
Short Talk: Targeting Tumor-Intrinsic RIG-I Signaling Initiates the Release of Immunogenic Extracellular Vesicles that Mediate
T Cell-Based Antitumor Immunity


Tuesday, June 05 | 5:00PM - 7:15PM
EVs and Regulation of the Immune Response
Room: Colorado Ballroom

Speaker 5 of 5
Jessy S. Deshane, University of Alabama at Birmingham, USA
Short Talk: Extracellular Vesicles from Airways of Asthmatics Promote Th2 and Th17 Polarization

Tuesday, June 05 | 7:15PM - 7:15PM
On Own for Dinner


Wednesday, June 06 | 7:30AM - 8:30AM
Breakfast
Room: Summit Gallery


Wednesday, June 06 | 8:30AM - 11:45AM
EVs and Cancer I (Tumor Growth and Dissemination)
Room: Colorado Ballroom

Speaker 1 of 7
Michael J. Powell, DiaCarta, Inc., USA
Precision Nucleic Acid Based Molecular Diagnostics Powered by Xenonucleic Acids

Wednesday, June 06 | 8:30AM - 11:45AM
EVs and Cancer I (Tumor Growth and Dissemination)
Room: Colorado Ballroom

Speaker 2 of 7
* Richard A. Cerione, Cornell University, USA
Probing the Mechanisms of Extracellular Vesicle Biogenesis and Function in Cancer and Development

Wednesday, June 06 | 8:30AM - 11:45AM
EVs and Cancer I (Tumor Growth and Dissemination)
Room: Colorado Ballroom


Coffee Break

Wednesday, June 06 | 8:30AM - 11:45AM
EVs and Cancer I (Tumor Growth and Dissemination)
Room: Colorado Ballroom

Speaker 4 of 7
Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
Generation and Testing of Clinical-Grade Engineered Exosomes to Facilitate Therapeutic Targeting of Oncogenic KRAS in Pancreatic Cancer

Wednesday, June 06 | 8:30AM - 11:45AM
EVs and Cancer I (Tumor Growth and Dissemination)
Room: Colorado Ballroom

Speaker 5 of 7
Clotilde Théry, Institut Curie, France
Biochemical and Functional Heterogeneity of Extracellular Vesicles in Cancer-Immune Crosstalk

Wednesday, June 06 | 8:30AM - 11:45AM
EVs and Cancer I (Tumor Growth and Dissemination)
Room: Colorado Ballroom

Speaker 6 of 7
Leonora Balaj, Massachusetts General Hospital, USA
Short Talk: Longitudinal Analysis of Serum-Derived Extracellular RNA for Monitoring of Treatment Response to Targeted
Therapy in Glioblastomas


Wednesday, June 06 | 8:30AM - 11:45AM
EVs and Cancer I (Tumor Growth and Dissemination)
Room: Colorado Ballroom

Speaker 7 of 7
Haiying Zhang, Cornell University, USA
Short Talk: Identification of Distinct Nanoparticles and Subsets of Extracellular Vesicles by Asymmetric-Flow Field-Flow Fractionation

Wednesday, June 06 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, June 06 | 11:45AM - 1:00PM
Poster Setup
Room: Colorado Ballroom Foyer


Wednesday, June 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Ballroom Foyer


Wednesday, June 06 | 2:30PM - 4:30PM
Workshop 1
Room: Colorado Ballroom

Speaker 1 of 5
* Crislyn D'Souza-Schorey, University of Notre Dame, USA

Wednesday, June 06 | 2:30PM - 4:30PM
Workshop 1
Room: Colorado Ballroom

Speaker 2 of 5
Philip D. Stahl, Washington University in St. Louis, School of Medicine, USA
Special Lecture: The Exosome Paradigm of Intercellular Communication

Wednesday, June 06 | 2:30PM - 4:30PM
Workshop 1
Room: Colorado Ballroom

Speaker 3 of 5
John Pena, Weill Cornell Medical College, USA
Enhancing Extracellular Vesicle Imaging in Biological Fluids and Tissues using a Non-Reversible Fixative

Wednesday, June 06 | 2:30PM - 4:30PM
Workshop 1
Room: Colorado Ballroom

Speaker 4 of 5
Mikael Klingeborn, Duke University, USA
Retinal Exosomes as Therapeutic Targets and Diagnostic Biomarkers

Wednesday, June 06 | 2:30PM - 4:30PM
Workshop 1
Room: Colorado Ballroom

Speaker 5 of 5
Albert Lu, Stanford University, USA
A Genome-Wide CRISPR Screen using Barcoded-MicroRNAs Enables Systematic Interrogation of Extracellular Vesicle Biology

Wednesday, June 06 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, June 06 | 5:00PM - 7:00PM
EVs in Neurobiology: Neurodevelopment, Degeneration and Rege
neration

Room: Colorado Ballroom

Speaker 1 of 4
Andrew Hill, La Trobe University, Australia
Extracellular Vesicles - Their Role in Neurodegenerative Disease Pathogenesis

Wednesday, June 06 | 5:00PM - 7:00PM
EVs in Neurobiology: Neurodevelopment, Degeneration and Rege
neration

Room: Colorado Ballroom

Speaker 2 of 4
* Stefan Momma, Frankfurt University Hospital, Germany
Extracellular Vesicle-Mediated Communication from Blood to Brain Is Triggered by Neural Activity in vivo

Wednesday, June 06 | 5:00PM - 7:00PM
EVs in Neurobiology: Neurodevelopment, Degeneration and Rege
neration

Room: Colorado Ballroom

Speaker 3 of 4
Tsuneya Ikezu, Boston University School of Medicine, USA
Recent Progress in EV Biology in Neurodegenerative Disorders

Wednesday, June 06 | 5:00PM - 7:00PM
EVs in Neurobiology: Neurodevelopment, Degeneration and Rege
neration

Room: Colorado Ballroom

Speaker 4 of 4
Jason Shepherd, University of Utah, USA
Short Talk: Viral-Like Mechanisms of Neuronal Extracellular Vesicle Biogenesis

Wednesday, June 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, June 06 | 7:30PM - 10:00PM
Poster Session 2
Room: Colorado Ballroom Foyer


Thursday, June 07 | 7:30AM - 8:30AM
Breakfast
Room: Summit Gallery


Thursday, June 07 | 8:30AM - 11:30AM
EVs and Cancer II (Metastases)
Room: Colorado Ballroom

Speaker 1 of 6
David Lyden, Weill Cornell Medical College, USA
The Role of Tumor-Secreted Exosomes in Cancer Metastasis

Thursday, June 07 | 8:30AM - 11:30AM
EVs and Cancer II (Metastases)
Room: Colorado Ballroom

Speaker 2 of 6
* Janusz Rak, McGill University, Canada
Extracellular Vesicles and Brain Malignancies

Thursday, June 07 | 8:30AM - 11:30AM
EVs and Cancer II (Metastases)
Room: Colorado Ballroom


Coffee Break

Thursday, June 07 | 8:30AM - 11:30AM
EVs and Cancer II (Metastases)
Room: Colorado Ballroom

Speaker 4 of 6
Takahiro Ochiya, National Cancer Center Research Institute, Japan
EV-Mediated Micromanaging of Tumor Metastasis

Thursday, June 07 | 8:30AM - 11:30AM
EVs and Cancer II (Metastases)
Room: Colorado Ballroom

Speaker 5 of 6
Dihua Yu, University of Texas MD Anderson Cancer Center, USA
Tumor Microenvironment-Derived Exosomes in Metastasis and Immune Activation

Thursday, June 07 | 8:30AM - 11:30AM
EVs and Cancer II (Metastases)
Room: Colorado Ballroom

Speaker 6 of 6
Viktor Fleming, German Cancer Research Center, Germany
Short Talk: Induction of Myeloid-Derived Suppressor Cells via Tumor-Derived Extracellular Vesicles in Malignant Melanoma

Thursday, June 07 | 11:30AM - 5:00PM
On Own for Lunch


Thursday, June 07 | 11:30AM - 1:00PM
Poster Setup
Room: Colorado Ballroom Foyer


Thursday, June 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Ballroom Foyer


Thursday, June 07 | 2:30PM - 4:30PM
Workshop 2
Room: Colorado Ballroom

Speaker 1 of 4
* Alissa M. Weaver, Vanderbilt University School of Medicine, USA
Investigating the Role of Exosome Secretion in Cellular Migration by Live Imaging

Thursday, June 07 | 2:30PM - 4:30PM
Workshop 2
Room: Colorado Ballroom

Speaker 2 of 4
Amy E. Baek, University of Illinois at Urbana-Champaign, USA
Cholesterol Metabolite Promotes Breast Cancer Progression via Extracellular Vesicles

Thursday, June 07 | 2:30PM - 4:30PM
Workshop 2
Room: Colorado Ballroom

Speaker 3 of 4
Jörg Votteler, University of Utah, USA
Designed Proteins Induce Formation of Nanocage-Containing Vesicles

Thursday, June 07 | 2:30PM - 4:30PM
Workshop 2
Room: Colorado Ballroom

Speaker 4 of 4
Ana O'Loghlen, Queen Mary University of London, UK
The Bystander Effect of Exosomes in Senescence and Aging

Thursday, June 07 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, June 07 | 5:00PM - 7:15PM
Current and Emerging Technologies
Room: Colorado Ballroom

Speaker 1 of 5
Olivier De Wever, University of Ghent, Belgium
Standardized Analysis of Extracellular Vesicles in Liquid Biopsies

Thursday, June 07 | 5:00PM - 7:15PM
Current and Emerging Technologies
Room: Colorado Ballroom

Speaker 2 of 5
Huang-Ge Zhang, University of Louisville, USA
Development of Three Generations of Edible Plant Exosome-Like Nanovectors for Therapy

Thursday, June 07 | 5:00PM - 7:15PM
Current and Emerging Technologies
Room: Colorado Ballroom

Speaker 3 of 5
* David Issadore, University of Pennsylvania, USA
Optofluidics Platforms for Exosome-Based Diagnostics

Thursday, June 07 | 5:00PM - 7:15PM
Current and Emerging Technologies
Room: Colorado Ballroom

Speaker 4 of 5
Jina Ko, University of Pennsylvania, USA
Short Talk: Multiplexed Exosome Diagnostics Using Machine Learning Combined Nanofluidics

Thursday, June 07 | 5:00PM - 7:15PM
Current and Emerging Technologies
Room: Colorado Ballroom

Speaker 5 of 5
Robert R. Kitchen, Exosome Diagnostics, USA
Short Talk: A High-Performance Urine Exosomal-mRNA Signature to Rule-Out Healthy Individuals Suspected of Bladder Cancer

Thursday, June 07 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, June 07 | 7:30PM - 10:00PM
Poster Session 3
Room: Colorado Ballroom Foyer


Friday, June 08 | 7:30AM - 8:30AM
Breakfast
Room: Summit Gallery


Friday, June 08 | 8:30AM - 11:30AM
EVs in Host-Pathogen Interactions
Room: Colorado Ballroom

Speaker 1 of 7
Neta Regev-Rudzki, Weizmann Institute of Science, Israel
Malaria Parasites Regulate Secretion of Exosomes Carrying Distinct Cargo

Friday, June 08 | 8:30AM - 11:30AM
EVs in Host-Pathogen Interactions
Room: Colorado Ballroom

Speaker 2 of 7
* Jeff S. Schorey, University of Notre Dame, USA
Extracellular Vesicles: Friend or Foe in the Immune Response against a Mycobacterium tuberculosis Infection

Friday, June 08 | 8:30AM - 11:30AM
EVs in Host-Pathogen Interactions
Room: Colorado Ballroom


Coffee Break

Friday, June 08 | 8:30AM - 11:30AM
EVs in Host-Pathogen Interactions
Room: Colorado Ballroom

Speaker 4 of 7
Ana Claudia Torrecilhas, Universidade Federal de São Paulo, Brazil
Extracellular Vesicles Modulate Innate Immune Response in Protozoa Infection

Friday, June 08 | 8:30AM - 11:30AM
EVs in Host-Pathogen Interactions
Room: Colorado Ballroom

Speaker 5 of 7
Marlene Dreux, INSERM U1111 International Center for Research in Infectionology (CIRI) Lyon, France
Flavor of Flavivirus by Plasmacytoid Dendritic Cells

Friday, June 08 | 8:30AM - 11:30AM
EVs in Host-Pathogen Interactions
Room: Colorado Ballroom

Speaker 6 of 7
João Pedra, University of Maryland School of Medicine, USA
Short Talk: Trans-Kingdom Intercommunication at the Vector-Pathogen-Host Interface

Friday, June 08 | 8:30AM - 11:30AM
EVs in Host-Pathogen Interactions
Room: Colorado Ballroom

Speaker 7 of 7
Sreenivas Gannavaram, US Food and Drug Administration, USA
Short Talk: Role of Exosomal MicroRNAs in Shaping Protective Immunity Induced by Live Attenuated Leishmania Vaccines

Friday, June 08 | 11:30AM - 5:00PM
On Own for Lunch


Friday, June 08 | 3:00PM - 4:30PM
Meet the NIH Staff: Opportunities
Room: Colorado Ballroom

Speaker 1 of 3
Aaron Pawlyk, Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA
Overview of the NIH and NIDDK

Friday, June 08 | 3:00PM - 4:30PM
Meet the NIH Staff: Opportunities
Room: Colorado Ballroom

Speaker 2 of 3
Olivier Blondel, NIDDK, National Institutes of Health, USA
Exosome/Microvesicle-Relevant Opportunities at the NIDDK

Friday, June 08 | 3:00PM - 4:30PM
Meet the NIH Staff: Opportunities
Room: Colorado Ballroom

Speaker 3 of 3
Matthew R. Young, NCI, National Institutes of Health, USA
Overview and Exosome/Microvesicle-Relevant Opportunities at the NCI

Friday, June 08 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, June 08 | 5:00PM - 6:45PM
EV Therapeutics
Room: Colorado Ballroom

Speaker 1 of 3
* Johan Skog, Exosome Diagnostics, Inc., USA
Current State of Exosome-Based Diagnostics

Friday, June 08 | 5:00PM - 6:45PM
EV Therapeutics
Room: Colorado Ballroom

Speaker 2 of 3
Jan Lötvall, University of Gothenburg, Sweden
Potential of Extracellular Vesicles for Therapeutic Uses

Friday, June 08 | 5:00PM - 6:45PM
EV Therapeutics
Room: Colorado Ballroom

Speaker 3 of 3
Eva Rohde, Paracelsus Medical University Salzburg, Austria
Pharmaceutical Engineering and Clinical Testing of Stromal Cell-Derived Extracellular Vesicles

Friday, June 08 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Colorado Ballroom


Friday, June 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Friday, June 08 | 8:00PM - 11:00PM
Entertainment
Room: Breckenridge Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Friday, June 08 | 8:00PM - 11:00PM
Cash Bar
Room: Breckenridge Ballroom


Saturday, June 09 | 10:24AM - 10:24AM
Departure


*Session Chair.