Web Desc
Novel Aspects of Bone Biology
Organizer(s): Gerard Karsenty and David T. Scadden
Date: June 13 - 16, 2018
Location: Snowbird Resort, Snowbird, UT, USA
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
This conference presents recent progress made in two relatively novel areas of skeletal biology not covered by other meetings. The first one is the cross-talk between bone, hematopoiesis and leukemogenesis. The second is the study of the various endocrine functions of bone and how their study impacts on our understanding of multiple degenerative diseases. Meetings of bone biology are traditionally dominated by the need to explain the basis and to propose treatments for the most frequent bone disease: osteoporosis. Aside from this very vivid field, these two other novel aspects of bone biology have developed in the last decade. A shared feature is that they link bone biology to multiple other organs and to other functions besides making bones. This conference showcases the many advances made in these two aspects of skeleton biology and how these developments have enriched our understanding of the pathogenesis of multiple degenerative diseases affecting the bone marrow, energy metabolism or the brain. Because of its very nature, this conference brings together investigators from different fields rarely afforded an opportunity to meet.
Scholarship Deadline: February 27 2018
Discounted Abstract Deadline: February 27 2018
Abstract Deadline: March 27 2018
Discounted Registration Deadline: April 12 2018
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
The Journal of Rheumatology
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Grant No. 1R13AR073678-01
Funding for this conference was made possible (in part) by 1R13AR073678-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, June 13 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Wednesday, June 13 | 6:00PM - 8:00PM
Welcome Mixer
Room: Ballroom Lobby
No registration fees are used to fund alcohol served at this function.

Thursday, June 14 | 7:30AM - 8:30AM
Breakfast
Room: Primrose


Thursday, June 14 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Ballroom 3

Speaker 1 of 2
* Christa Maes, KU Leuven, Belgium

Thursday, June 14 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Ballroom 3

Speaker 2 of 2
Daniel E. Lieberman, Harvard University, USA
An Evolutionary Medical Perspective on Bone Disease

Thursday, June 14 | 9:30AM - 12:00PM
The Origin of the Osteoblast
Room: Ballroom 3

Speaker 1 of 7
* Christa Maes, KU Leuven, Belgium

Thursday, June 14 | 9:30AM - 12:00PM
The Origin of the Osteoblast
Room: Ballroom 3

Speaker 2 of 7
Roberta Faccio, Washington University, USA
Bone-Derived Dickkopf-Related Protein 1 (Dkk1) Exerts Immune-Suppressive Effects in Cancer

Thursday, June 14 | 9:30AM - 12:00PM
The Origin of the Osteoblast
Room: Ballroom 3


Coffee Break

Thursday, June 14 | 9:30AM - 12:00PM
The Origin of the Osteoblast
Room: Ballroom 3

Speaker 4 of 7
Siddhartha Mukherjee, Columbia University Medical Center, USA
Definition of a Post-Natal Osteoblast Stem Cell

Thursday, June 14 | 9:30AM - 12:00PM
The Origin of the Osteoblast
Room: Ballroom 3

Speaker 5 of 7
Henry M. Kronenberg, Massachusetts General Hospital, USA
Sox9-Expressing Cells Are Progenitors of Osteoblasts, Stromal Cells and Chondrocytes in Mouse Bone

Thursday, June 14 | 9:30AM - 12:00PM
The Origin of the Osteoblast
Room: Ballroom 3

Speaker 6 of 7
Shawon Debnath, Weill Cornell Medicine, Cornell University, USA
Short Talk: Identification of a Novel Periosteal Stem Cell Population that Mediates Intramembranous Bone Formation

Thursday, June 14 | 9:30AM - 12:00PM
The Origin of the Osteoblast
Room: Ballroom 3

Speaker 7 of 7
Constance T. Noguchi, NIDDK, National Institutes of Health, USA
Short Talk: Altered Erythropoietin Signaling Disrupts Bone Marrow Stromal Cell Differentiation

Thursday, June 14 | 12:00PM - 5:00PM
On Own for Lunch


Thursday, June 14 | 12:00PM - 1:00PM
Poster Setup
Room: Primrose


Thursday, June 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Thursday, June 14 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, June 14 | 5:00PM - 7:15PM
The Bone Marrow Niche
Room: Ballroom 3

Speaker 1 of 5
* Sabina Sangaletti, Fondazione IRCCS Istituto Tumori Milano, Italy

Thursday, June 14 | 5:00PM - 7:15PM
The Bone Marrow Niche
Room: Ballroom 3

Speaker 2 of 5
David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Defining (and applying) The Bone Marrow Niche

Thursday, June 14 | 5:00PM - 7:15PM
The Bone Marrow Niche
Room: Ballroom 3

Speaker 3 of 5
Sean J. Morrison, University of Texas Southwestern Medical Center, USA
The Maintenance of the Adult Skeleton

Thursday, June 14 | 5:00PM - 7:15PM
The Bone Marrow Niche
Room: Ballroom 3

Speaker 4 of 5
Paul S. Frenette, Albert Einstein College of Medicine, USA
Neural Regulation of the Aging Bone Marrow Niche


Thursday, June 14 | 5:00PM - 7:15PM
The Bone Marrow Niche
Room: Ballroom 3

Speaker 5 of 5
John Chute, University of California, Los Angeles, USA
Bone Marrow Osteolineage Cells Regulate Hematopoietic Regeneration via Secretion of Dkk1

Thursday, June 14 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Primrose
No registration fees are used to fund alcohol served at this function.

Thursday, June 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Primrose


Friday, June 15 | 7:30AM - 8:30AM
Breakfast
Room: Primrose


Friday, June 15 | 8:30AM - 11:45AM
The Endocrine Function of the Osteoblast

Room: Ballroom 3

Speaker 1 of 8
* Mathieu Ferron, Institut de Recherches Cliniques de Montréal, Canada

Friday, June 15 | 8:30AM - 11:45AM
The Endocrine Function of the Osteoblast

Room: Ballroom 3

Speaker 2 of 8
Gerard Karsenty, Columbia University Medical Center, USA
Osteocalcin Is Necessary and Sufficient to Mount an Acute Stress Response

Friday, June 15 | 8:30AM - 11:45AM
The Endocrine Function of the Osteoblast

Room: Ballroom 3

Speaker 3 of 8
Aline Bozec, University of Erlangen, Germany
High-Fat Diet and Microbiota Control the Bone Marrow Niche and Hematopoietic Stem Cell Differentiation

Friday, June 15 | 8:30AM - 11:45AM
The Endocrine Function of the Osteoblast

Room: Ballroom 3


Coffee Break

Friday, June 15 | 8:30AM - 11:45AM
The Endocrine Function of the Osteoblast

Room: Ballroom 3

Speaker 5 of 8
Seiji Fukumoto, Tokushima University, Japan
The Biology of FGF23

Friday, June 15 | 8:30AM - 11:45AM
The Endocrine Function of the Osteoblast

Room: Ballroom 3

Speaker 6 of 8
Yihong Wan, University of Texas Southwestern Medical Center, USA
Endocrine and Metabolic Regulation of Osteoclastogenesis

Friday, June 15 | 8:30AM - 11:45AM
The Endocrine Function of the Osteoblast

Room: Ballroom 3

Speaker 7 of 8
Omar Al Rifai, Clinical Research Institute of Montreal, IRCM, Canada
Short Talk: Proprotein Convertase Furin is a Novel Pleiotropic Regulator of Bone Endocrine Functions

Friday, June 15 | 8:30AM - 11:45AM
The Endocrine Function of the Osteoblast

Room: Ballroom 3

Speaker 8 of 8
Julian Berger, Columbia University Medical Center, USA
Short Talk: Osteocalcin Signaling in the Adrenal Cortex is Necessary for Steroid Hormones Biosynthesis and Adrenal Gland Growth

Friday, June 15 | 11:45AM - 5:00PM
On Own for Lunch


Friday, June 15 | 11:45AM - 1:00PM
Poster Setup
Room: Primrose


Friday, June 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Friday, June 15 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Friday, June 15 | 5:00PM - 7:00PM
The Relationship between Bone and Leukemia
Room: Ballroom 3

Speaker 1 of 5
* Lev Silberstein, Fred Hutchinson Cancer Research Center, USA

Friday, June 15 | 5:00PM - 7:00PM
The Relationship between Bone and Leukemia
Room: Ballroom 3

Speaker 2 of 5
Emmanuelle Passegué, Columbia University, USA
Aging of Stem Cells and Leukemogenesis

Friday, June 15 | 5:00PM - 7:00PM
The Relationship between Bone and Leukemia
Room: Ballroom 3

Speaker 3 of 5
Stavroula Kousteni, Columbia University, USA
The Osteoblast as an Inducer of Leukemogenesis

Friday, June 15 | 5:00PM - 7:00PM
The Relationship between Bone and Leukemia
Room: Ballroom 3

Speaker 4 of 5
Stéphane J. C. Mancini, INSERM, France
Short Talk: Hematopoietic Stem Cells and Early B Cells Form Specific Interaction Networks with A Unique Peri-Sinusoidal Stromal Cell Niche in the Bone Marrow

Friday, June 15 | 5:00PM - 7:00PM
The Relationship between Bone and Leukemia
Room: Ballroom 3

Speaker 5 of 5
Annas Al-Sharea, Baker IDI Heart and Diabetes Institute, Australia
Short Talk: Cholinergic Regulation of Bone Marrow Vascular Microenvironment Influences Hematopoietic Stem Cell Mobilization

Friday, June 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Primrose
No registration fees are used to fund alcohol served at this function.

Friday, June 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Primrose


Saturday, June 16 | 7:30AM - 8:30AM
Breakfast
Room: Primrose


Saturday, June 16 | 8:30AM - 11:30AM
Molecular Genetics of Bone Metastasis
Room: Ballroom 3

Speaker 1 of 7
* Patricia Ducy, Columbia University, USA

Saturday, June 16 | 8:30AM - 11:30AM
Molecular Genetics of Bone Metastasis
Room: Ballroom 3

Speaker 2 of 7
Yibin Kang, Princeton University, USA
The Role of Bone Stromal Niches in the Seeding, Outgrowth and Treatment Resistance of Bone Metastasis

Saturday, June 16 | 8:30AM - 11:30AM
Molecular Genetics of Bone Metastasis
Room: Ballroom 3

Speaker 3 of 7
Theresa A. Guise, Indiana University, USA
Systemic Effects of the Tumor-Bone Microenvironment: Mechanisms and Therapeutic Approaches

Saturday, June 16 | 8:30AM - 11:30AM
Molecular Genetics of Bone Metastasis
Room: Ballroom 3


Coffee Break

Saturday, June 16 | 8:30AM - 11:30AM
Molecular Genetics of Bone Metastasis
Room: Ballroom 3

Speaker 5 of 7
G. David Roodman, Indiana University, USA
The Pathogenesis of Multiple Myeloma

Saturday, June 16 | 8:30AM - 11:30AM
Molecular Genetics of Bone Metastasis
Room: Ballroom 3

Speaker 6 of 7
Camilla Engblom, Massachusetts General Hospital, USA
Lung Tumors Talk to Bones and Bones Answer Back

Saturday, June 16 | 8:30AM - 11:30AM
Molecular Genetics of Bone Metastasis
Room: Ballroom 3

Speaker 7 of 7
Aaron E. Chiou, Cornell University, USA
Short Talk: Investigating Pre-Metastatic Alterations of Bone Extracellular Matrix

Saturday, June 16 | 11:30AM - 5:00PM
On Own for Lunch


Saturday, June 16 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Saturday, June 16 | 5:00PM - 6:45PM
The Relationship between Bone and the Immune System
Room: Ballroom 3

Speaker 1 of 3
Hiroshi Takayanagi, University of Tokyo, Japan
Interaction between Bone and the Immune System


Saturday, June 16 | 5:00PM - 6:45PM
The Relationship between Bone and the Immune System
Room: Ballroom 3

Speaker 2 of 3
Rheinallt M. Jones, Emory University, USA
The Influence of the Gut Microbiota on Bone Metabolism: In Pursuit of Mechanisms

Saturday, June 16 | 5:00PM - 6:45PM
The Relationship between Bone and the Immune System
Room: Ballroom 3

Speaker 3 of 3
Ralf H. Adams, Max Planck Institute for Molecular Biomedicine, Germany
Blood Vessel Growth, Function and Aging in the Skeletal System

Saturday, June 16 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Ballroom 3


Saturday, June 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 2
No registration fees are used to fund alcohol served at this function.

Saturday, June 16 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Saturday, June 16 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 2


Sunday, June 17 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.