Web Desc
B Cells: Mechanisms in Immunity and Autoimmunity
Organizer(s): Lars Nitschke, Michael Reth, Roberta Pelanda and David M. Tarlinton
Date: June 17 - 21, 2018
Location: Maritim Hotel & International Congress Center Dresden, Dresden, Germany
Sponsored by Genentech, Inc., MSD, and Roche
Summary of Meeting:
B cells play an important role in immunity and immunology research. New findings about the relevance and contribution of B cells to autoimmunity have rejuvenated interest in B cell immunology research. B cell functions unrelated to the production of antibodies have also been recently uncovered, indicating B cells operate in the context of both humoral and cellular adaptive immune responses. These B cell properties have stimulated a plethora of studies aimed at discovering the molecular mechanisms of B cell development and diversification, B cell activation, B cell memory responses and B cell tolerance induction. Affinity maturation of antibodies within the germinal center is now considered to be more complex than previously thought. The generation of broadly neutralizing antibodies against viruses in a few, but not all individuals, and the generation of autoantibodies during germinal center responses, have challenged existing dogmas. B cell metabolism and its intersection with the microbiome are stimulating and exciting areas only now beginning to be explored. Antibody-independent functions of B cells, for example in secreting inflammatory or regulatory cytokines, suggest B cells are relevant in many inflammatory and allergic diseases. This conference aims to address the mechanisms of B cell activation, B cell differentiation and B cell responses, and the contribution of B cells to the development of autoimmune diseases. Potential new treatment options for these diseases will also be covered.
Scholarship Deadline: February 14 2018
Discounted Abstract Deadline: February 14 2018
Abstract Deadline: March 14 2018
Discounted Registration Deadline: April 17 2018
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Genentech, Inc.MSDRoche
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI138574-01
Funding for this conference was made possible (in part) by 1R13AI138574-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, June 17 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Sunday, June 17 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Monday, June 18 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Saal 4/5

Speaker 1 of 2
* Roberta Pelanda, University of Colorado Denver, USA

Monday, June 18 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Saal 4/5

Speaker 2 of 2
Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Germinal Centers and Memory B Cells

Monday, June 18 | 9:30AM - 12:00PM
B Cell Differentiation
Room: Saal 4/5

Speaker 1 of 8
* Anja Erika Hauser, Charité-Universitätsmedizin, Germany

Monday, June 18 | 9:30AM - 12:00PM
B Cell Differentiation
Room: Saal 4/5

Speaker 2 of 8
* Lill Martensson, University of Gothenburg, Sweden

Monday, June 18 | 9:30AM - 12:00PM
B Cell Differentiation
Room: Saal 4/5

Speaker 3 of 8
Martin Turner, Babraham Institute, UK
Regulation of B Cell Development by RNA Binding Proteins

Monday, June 18 | 9:30AM - 12:00PM
B Cell Differentiation
Room: Saal 4/5


Coffee Break

Monday, June 18 | 9:30AM - 12:00PM
B Cell Differentiation
Room: Saal 4/5

Speaker 5 of 8
Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Suppression of Autoimmunity by the Transcription Factor Ikaros

Monday, June 18 | 9:30AM - 12:00PM
B Cell Differentiation
Room: Saal 4/5

Speaker 6 of 8
Marion Pepper, University of Washington, USA
Memory B Cells in Malaria Infections

Monday, June 18 | 9:30AM - 12:00PM
B Cell Differentiation
Room: Saal 4/5

Speaker 7 of 8
Anselm Enders, John Curtin School of Medical Research, Australia
Short Talk: Deregulation of PAX5 Causes Abnormal B Cell Lymphopoiesis and Spontaneous Precursor B Cell Lymphoma Development in Mice

Monday, June 18 | 9:30AM - 12:00PM
B Cell Differentiation
Room: Saal 4/5

Speaker 8 of 8
Klaus D. Fischer, Medical Faculty Magdeburg, Germany
Short Talk: The Opposing Forces of Shear Flow and Sphingosine-1-Phosphate Control Marginal Zone B Cell Shuttling

Monday, June 18 | 12:00PM - 5:00PM
On Own for Lunch


Monday, June 18 | 12:00PM - 1:00PM
Poster Setup
Room: Saal 3


Monday, June 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Saal 3


Monday, June 18 | 2:30PM - 4:30PM
Workshop 1: Signals Driving Development of Conventional and
Innate B Cells
Room: Saal 4/5

Speaker 1 of 10
* João Pereira, Yale University School of Medicine, USA

Monday, June 18 | 2:30PM - 4:30PM
Workshop 1: Signals Driving Development of Conventional and
Innate B Cells
Room: Saal 4/5

Speaker 2 of 10
* Nicole Baumgarth, University of California, Davis, USA

Monday, June 18 | 2:30PM - 4:30PM
Workshop 1: Signals Driving Development of Conventional and
Innate B Cells
Room: Saal 4/5

Speaker 3 of 10
Duane R. Wesemann, Harvard Medical School, USA
Stochastic B Cell Diversification in Germinal Centers

Monday, June 18 | 2:30PM - 4:30PM
Workshop 1: Signals Driving Development of Conventional and
Innate B Cells
Room: Saal 4/5

Speaker 4 of 10
Meihong Deng, University of Pittsburgh, USA
TLR9 Regulates Host Defense via Modulation of Peritoneal B1 Cell Pathobiology during Intra-Abdominal Sepsis

Monday, June 18 | 2:30PM - 4:30PM
Workshop 1: Signals Driving Development of Conventional and
Innate B Cells
Room: Saal 4/5

Speaker 5 of 10
Stijn Vanhee, Lund University, Sweden
B Cell Positive Selection Is Developmentally Regulated during Ontogeny by the Heterochronic Protein Lin28b

Monday, June 18 | 2:30PM - 4:30PM
Workshop 1: Signals Driving Development of Conventional and
Innate B Cells
Room: Saal 4/5

Speaker 6 of 10
Wenxia Song, University of Maryland, USA
BCR-Antigen Interaction Causes Wounding and Repair of the B Cell Membrane, Promoting BCR Activation

Monday, June 18 | 2:30PM - 4:30PM
Workshop 1: Signals Driving Development of Conventional and
Innate B Cells
Room: Saal 4/5

Speaker 7 of 10
Sandra Eva Zehentmeier, Yale School of Medicine, USA
Get Your Motor Runnin’: Control of B Cell Receptor Signaling through Gai Protein-Mediated Chemoattractant Sensing

Monday, June 18 | 2:30PM - 4:30PM
Workshop 1: Signals Driving Development of Conventional and
Innate B Cells
Room: Saal 4/5

Speaker 8 of 10
Carolin Ulbricht, Charité Universitätsmedizin Berlin, Germany
Tracking B Cell Receptor Signaling during Germinal Center Reactions in vivo

Monday, June 18 | 2:30PM - 4:30PM
Workshop 1: Signals Driving Development of Conventional and
Innate B Cells
Room: Saal 4/5

Speaker 9 of 10
Daniela Giordano, University of Washington, USA
Expression of and Requirement for B Cell Activating Factor (BAFF) during West Nile Virus (WNV) and Salmonella Infection

Monday, June 18 | 2:30PM - 4:30PM
Workshop 1: Signals Driving Development of Conventional and
Innate B Cells
Room: Saal 4/5

Speaker 10 of 10
Simar Pal Singh, Erasmus MC, Netherlands
T Cells Shape the Immunoglobulin Repertoire of Murine Chronic Lymphocytic Leukemia while B Cell Receptor Signaling Strength Controls Age of Onset

Monday, June 18 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, June 18 | 5:00PM - 7:15PM
Innate Functions of B Cells
Room: Saal 4/5

Speaker 1 of 7
* Michelle A. Linterman, Babraham Institute, UK

Monday, June 18 | 5:00PM - 7:15PM
Innate Functions of B Cells
Room: Saal 4/5

Speaker 2 of 7
* Randall S. Davis, University of Alabama, Birmingham, USA

Monday, June 18 | 5:00PM - 7:15PM
Innate Functions of B Cells
Room: Saal 4/5

Speaker 3 of 7
Nicole Baumgarth, University of California, Davis, USA
Regulation of B-1 Cell Functions

Monday, June 18 | 5:00PM - 7:15PM
Innate Functions of B Cells
Room: Saal 4/5

Speaker 4 of 7
Simon Fillatreau, Institut Necker Enfants Malades, France
Regulatory Roles of B Cells in Autoimmune and Infectious Diseases

Monday, June 18 | 5:00PM - 7:15PM
Innate Functions of B Cells
Room: Saal 4/5

Speaker 5 of 7
Claudia Mauri, University College London, UK
How Regulatory B Cells Bridge the Innate and the Adaptive Immune Response

Monday, June 18 | 5:00PM - 7:15PM
Innate Functions of B Cells
Room: Saal 4/5

Speaker 6 of 7
Yoontae Lee, Pohang University of Science and Technology, South Korea
Short Talk: Transcriptional Regulation of B-1 and B-2 Cell Fates by Capicua

Monday, June 18 | 5:00PM - 7:15PM
Innate Functions of B Cells
Room: Saal 4/5

Speaker 7 of 7
Marc Seifert, University of Duisburg-Essen, Germany
Short Talk: Molecular and Functional Characterization of Human B-1a Cells

Monday, June 18 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Terrassen Foyer
No registration fees are used to fund alcohol served at this function.

Monday, June 18 | 7:30PM - 10:00PM
Poster Session 1
Room: Saal 3


Tuesday, June 19 | 8:00AM - 8:30AM
Poster Setup
Room: Saal 3


Tuesday, June 19 | 8:30AM - 5:00PM
Poster Viewing
Room: Saal 3


Tuesday, June 19 | 8:30AM - 11:45AM
Checkpoint Control of B Cell Signaling
Room: Saal 4/5

Speaker 1 of 9
* Raul M. Torres, University of Colorado School of Medicine, USA

Tuesday, June 19 | 8:30AM - 11:45AM
Checkpoint Control of B Cell Signaling
Room: Saal 4/5

Speaker 2 of 9
* Victor L.J. Tybulewicz, Francis Crick Institute, UK

Tuesday, June 19 | 8:30AM - 11:45AM
Checkpoint Control of B Cell Signaling
Room: Saal 4/5

Speaker 3 of 9
Julia Jellusova, University of Freiburg, Germany
The Role of the B Cell Receptor in Regulating Metabolic Fitness

Tuesday, June 19 | 8:30AM - 11:45AM
Checkpoint Control of B Cell Signaling
Room: Saal 4/5

Speaker 4 of 9
Michael Reth, Albert-Ludwigs University Freiburg, Germany
The Nanoscale Organization of the BCR and the B Cell Membrane

Tuesday, June 19 | 8:30AM - 11:45AM
Checkpoint Control of B Cell Signaling
Room: Saal 4/5


Coffee Break

Tuesday, June 19 | 8:30AM - 11:45AM
Checkpoint Control of B Cell Signaling
Room: Saal 4/5

Speaker 6 of 9
Jürgen Wienands, Georg August University of Goettingen, Germany
The Scaffolding Protein CIN85 Controls BCR Responsiveness and Subsequent Antibody Responses in Humans

Tuesday, June 19 | 8:30AM - 11:45AM
Checkpoint Control of B Cell Signaling
Room: Saal 4/5

Speaker 7 of 9
Markus Müschen, Beckman Research Institute, USA
Autoimmunity Checkpoints in B Cell Malignancies

Tuesday, June 19 | 8:30AM - 11:45AM
Checkpoint Control of B Cell Signaling
Room: Saal 4/5

Speaker 8 of 9
Kerstin Nündel, University of Massachusetts Medical School, USA
Short Talk: Divergent Roles for TLR7 and TLR9 in Modulating the NFkB Pathway in B Cells

Tuesday, June 19 | 8:30AM - 11:45AM
Checkpoint Control of B Cell Signaling
Room: Saal 4/5

Speaker 9 of 9
Susana Minguet, Biology III and BIOSS, Germany
Short Talk: Caveolin-1-Dependent Nanoscale Organization of the BCR Regulates B Cell Tolerance

Tuesday, June 19 | 11:45AM - 12:30PM
Lunch
Room: Terrassen Foyer


Tuesday, June 19 | 12:00PM - 2:30PM
Poster Session 2
Room: Saal 3


Tuesday, June 19 | 2:30PM - 4:30PM
Workshop 2: Germinal Centers and Humoral Immune Response
Room: Saal 4/5

Speaker 1 of 10
* Hedda Wardemann, German Cancer Research Center, Germany

Tuesday, June 19 | 2:30PM - 4:30PM
Workshop 2: Germinal Centers and Humoral Immune Response
Room: Saal 4/5

Speaker 2 of 10
* Kai-Michael Toellner, University of Birmingham, UK

Tuesday, June 19 | 2:30PM - 4:30PM
Workshop 2: Germinal Centers and Humoral Immune Response
Room: Saal 4/5

Speaker 3 of 10
Michelle A. Mintz, University of California, San Francisco, USA
The HVEM-BTLA Interaction Restrains the Germinal Center Response

Tuesday, June 19 | 2:30PM - 4:30PM
Workshop 2: Germinal Centers and Humoral Immune Response
Room: Saal 4/5

Speaker 4 of 10
Floriana Cremasco, Università Vita Salute San Raffaele, Italy
Autophagy-Independent Control of the Germinal Center Reaction by the Adapter SQSTM1/p62

Tuesday, June 19 | 2:30PM - 4:30PM
Workshop 2: Germinal Centers and Humoral Immune Response
Room: Saal 4/5

Speaker 5 of 10
Michelle A. Linterman, Babraham Institute, UK
Type I Interferon Induces CXCL13-Driven B Cell Recruitment to the Lung to Enable Tertiary Germinal Centre Formation

Tuesday, June 19 | 2:30PM - 4:30PM
Workshop 2: Germinal Centers and Humoral Immune Response
Room: Saal 4/5

Speaker 6 of 10
Imogen Moran, Garvan Institute of Medical Research, Australia
Where and How Memory Cells Are Reactivated in the Secondary Antibody Response in the Lymph Node

Tuesday, June 19 | 2:30PM - 4:30PM
Workshop 2: Germinal Centers and Humoral Immune Response
Room: Saal 4/5

Speaker 7 of 10
Dessi Malinova, Francis Crick Institute, UK
Genome-Wide CRISPR/Cas9 Screens Identify Components of B Cell Antigen Internalization

Tuesday, June 19 | 2:30PM - 4:30PM
Workshop 2: Germinal Centers and Humoral Immune Response
Room: Saal 4/5

Speaker 8 of 10
Yuezhou Chen, Brigham and Women's Hospital, USA
Primary Ig Repertoire Control as a Demand-Driven Process

Tuesday, June 19 | 2:30PM - 4:30PM
Workshop 2: Germinal Centers and Humoral Immune Response
Room: Saal 4/5

Speaker 9 of 10
Kim Good-Jacobson, Monash University, Australia
Histone-Modifying Complexes Differentially Regulate B Cell Fate Decisions during Acute and Chronic Infection

Tuesday, June 19 | 2:30PM - 4:30PM
Workshop 2: Germinal Centers and Humoral Immune Response
Room: Saal 4/5

Speaker 10 of 10
Ian A. Cockburn, Australian National University, Australia
New Approaches to Track B Cells Specific for a Major Malaria Vaccine Candidate

Tuesday, June 19 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, June 19 | 5:00PM - 7:15PM
Diversification of Antibodies and Humoral Immune Response
Room: Saal 4/5

Speaker 1 of 7
* Berit Jungnickel, Friedrich Schiller University Jena, Germany

Tuesday, June 19 | 5:00PM - 7:15PM
Diversification of Antibodies and Humoral Immune Response
Room: Saal 4/5

Speaker 2 of 7
* Gabriel D. Victora, Rockefeller University, USA

Tuesday, June 19 | 5:00PM - 7:15PM
Diversification of Antibodies and Humoral Immune Response
Room: Saal 4/5

Speaker 3 of 7
Javier M. Di Noia, Institut de Recherches Cliniques de Montreal, Canada
Structure-Function of AID Uncovers a Licensing Step for Antibody Gene Diversification

Tuesday, June 19 | 5:00PM - 7:15PM
Diversification of Antibodies and Humoral Immune Response
Room: Saal 4/5

Speaker 4 of 7
Tomohiro Kurosaki, Osaka University, Japan
Fate Decision of Germinal Center B Cells

Tuesday, June 19 | 5:00PM - 7:15PM
Diversification of Antibodies and Humoral Immune Response
Room: Saal 4/5

Speaker 5 of 7
Daisuke Kitamura, Tokyo University of Science, Japan
Regulatory Mechanisms for Memory B Cell Development and Function

Tuesday, June 19 | 5:00PM - 7:15PM
Diversification of Antibodies and Humoral Immune Response
Room: Saal 4/5

Speaker 6 of 7
Robert Abbott, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

Tuesday, June 19 | 5:00PM - 7:15PM
Diversification of Antibodies and Humoral Immune Response
Room: Saal 4/5

Speaker 7 of 7
Berit Jungnickel, Friedrich Schiller University Jena, Germany
Short Talk: Regulation of AID Activity and DNA Repair during Somatic Hypermutation

Tuesday, June 19 | 7:15PM - 7:15PM
On Own for Dinner


Wednesday, June 20 | 8:30AM - 11:45AM
Germinal Centers and B Cell Memory Formation
Room: Saal 4/5

Speaker 1 of 9
* Marion Pepper, University of Washington, USA

Wednesday, June 20 | 8:30AM - 11:45AM
Germinal Centers and B Cell Memory Formation
Room: Saal 4/5

Speaker 2 of 9
* Oliver Bannard, University of Oxford, UK

Wednesday, June 20 | 8:30AM - 11:45AM
Germinal Centers and B Cell Memory Formation
Room: Saal 4/5

Speaker 3 of 9
Gabriel D. Victora, Rockefeller University, USA
Clonal and Cellular Dynamics of Germinal Center Selection

Wednesday, June 20 | 8:30AM - 11:45AM
Germinal Centers and B Cell Memory Formation
Room: Saal 4/5

Speaker 4 of 9
Carola G. Vinuesa, Australian National University, Australia
T Follicular Helper Cells in the Germinal Center

Wednesday, June 20 | 8:30AM - 11:45AM
Germinal Centers and B Cell Memory Formation
Room: Saal 4/5


Coffee Break

Wednesday, June 20 | 8:30AM - 11:45AM
Germinal Centers and B Cell Memory Formation
Room: Saal 4/5

Speaker 6 of 9
David M. Tarlinton, Monash University, Australia
Germinal Center-Derived Plasma Cells

Wednesday, June 20 | 8:30AM - 11:45AM
Germinal Centers and B Cell Memory Formation
Room: Saal 4/5

Speaker 7 of 9
Shannon J. Turley, Genentech, Inc., USA
Fibroblastic Reticular Cells and the Maintenance of B Cell Follicles

Wednesday, June 20 | 8:30AM - 11:45AM
Germinal Centers and B Cell Memory Formation
Room: Saal 4/5

Speaker 8 of 9
Ziv Shulman, Weizmann Institute, Israel
Short Talk: Germinal Centers: Arrivals, Departures and the T Cell Border Control

Wednesday, June 20 | 8:30AM - 11:45AM
Germinal Centers and B Cell Memory Formation
Room: Saal 4/5

Speaker 9 of 9
Hedda Wardemann, German Cancer Research Center, Germany
Short Talk: The Role of Clonal Selection Versus Affinity Maturation in the Human B Cell Response to a Repetitive Malaria Parasite Antigen

Wednesday, June 20 | 11:45AM - 1:00PM
Poster Setup
Room: Saal 3


Wednesday, June 20 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, June 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Saal 3


Wednesday, June 20 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, June 20 | 5:00PM - 7:15PM
B Cell Metabolism and Intersection with the Microbiome
Room: Saal 4/5

Speaker 1 of 7
* Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA

Wednesday, June 20 | 5:00PM - 7:15PM
B Cell Metabolism and Intersection with the Microbiome
Room: Saal 4/5

Speaker 2 of 7
* Ziv Shulman, Weizmann Institute, Israel

Wednesday, June 20 | 5:00PM - 7:15PM
B Cell Metabolism and Intersection with the Microbiome
Room: Saal 4/5

Speaker 3 of 7
Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Germany
Regulation of Intestinal TGFß and IgA by a Distinct Microbiota


Wednesday, June 20 | 5:00PM - 7:15PM
B Cell Metabolism and Intersection with the Microbiome
Room: Saal 4/5

Speaker 4 of 7
Joseph E. Craft, Yale University, USA
The Role of Tfh Cells in B-Cell Selection


Wednesday, June 20 | 5:00PM - 7:15PM
B Cell Metabolism and Intersection with the Microbiome
Room: Saal 4/5

Speaker 5 of 7
Nicola L. Harris, Monash University, Australia
B Cell-Stomal Cell Interactions Drive Lymphoid Remodeling and Are Required for Efficient Adaptive Immune Responses against Intestinal Helminths

Wednesday, June 20 | 5:00PM - 7:15PM
B Cell Metabolism and Intersection with the Microbiome
Room: Saal 4/5

Speaker 6 of 7
Lieselotte S.M. Kreuk, University of California, Berkeley, USA
Short Talk: B Cell Receptor and Toll-Like Receptor Signaling Integrate to Control B1-Derived Anti-Commensal IgM, IgG, and IgA

Wednesday, June 20 | 5:00PM - 7:15PM
B Cell Metabolism and Intersection with the Microbiome
Room: Saal 4/5

Speaker 7 of 7
Romain Ballet, Stanford University, USA
Short Talk: CD22 Positively Controls a4ß7-Dependent B Cell Homing to the Peyer’s Patches

Wednesday, June 20 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Terrassen Foyer


Wednesday, June 20 | 7:30PM - 10:00PM
Poster Session 3
Room: Saal 3


Thursday, June 21 | 8:30AM - 11:45AM
B Cell Tolerance and Autoimmunity
Room: Saal 4/5

Speaker 1 of 9
* Julie Zikherman, University of California, San Francisco, USA

Thursday, June 21 | 8:30AM - 11:45AM
B Cell Tolerance and Autoimmunity
Room: Saal 4/5

Speaker 2 of 9
* Lars Nitschke, University of Erlangen, Germany

Thursday, June 21 | 8:30AM - 11:45AM
B Cell Tolerance and Autoimmunity
Room: Saal 4/5

Speaker 3 of 9
Roberta Pelanda, University of Colorado Denver, USA
Dual Antibody B Cells in Lupus, Mice and Humans

Thursday, June 21 | 8:30AM - 11:45AM
B Cell Tolerance and Autoimmunity
Room: Saal 4/5

Speaker 4 of 9
Takeshi Tsubata, Tokyo Medical and Dental University, Japan
The Inhibitory B Cell Co-Receptor CD72 Regulates Tolerance to Self Nucleic Acids Crucial for Development of Systemic Lupus Erythematosus

Thursday, June 21 | 8:30AM - 11:45AM
B Cell Tolerance and Autoimmunity
Room: Saal 4/5


Coffee Break

Thursday, June 21 | 8:30AM - 11:45AM
B Cell Tolerance and Autoimmunity
Room: Saal 4/5

Speaker 6 of 9
Julie Zikherman, University of California, San Francisco, USA
Regulation of B Cell Tolerance by Nur77

Thursday, June 21 | 8:30AM - 11:45AM
B Cell Tolerance and Autoimmunity
Room: Saal 4/5

Speaker 7 of 9
Lars Nitschke, University of Erlangen, Germany
CD22 and Siglec-G Are Inhibitory Receptors on B Cells and Prevent Autoimmunity

Thursday, June 21 | 8:30AM - 11:45AM
B Cell Tolerance and Autoimmunity
Room: Saal 4/5

Speaker 8 of 9
Jeremy F. Brooks, University of Queensland, Australia
Short Talk: Characterizing Self-Reactive B Cell Responses in a Polyclonal Repertoire

Thursday, June 21 | 8:30AM - 11:45AM
B Cell Tolerance and Autoimmunity
Room: Saal 4/5

Speaker 9 of 9
Joanne H. Reed, Garvan Institute of Medical Research, Australia
Short Talk: Single Cell Analysis of Self-Reactive B Cells in Autoimmune Disease

Thursday, June 21 | 11:45AM - 5:00PM
On Own for Lunch


Thursday, June 21 | 2:30PM - 4:30PM
Workshop 3: Autoimmunity
Room: Saal 4/5

Speaker 1 of 10
* John C. Cambier, University of Colorado, USA

Thursday, June 21 | 2:30PM - 4:30PM
Workshop 3: Autoimmunity
Room: Saal 4/5

Speaker 2 of 10
* Simon Fillatreau, Institut Necker Enfants Malades, France

Thursday, June 21 | 2:30PM - 4:30PM
Workshop 3: Autoimmunity
Room: Saal 4/5

Speaker 3 of 10
Betsy J. Barnes, Feinstein Institute for Medical Research, USA
Targeting IRF5 Hyper-Activation in SLE B Cells Inhibits Disease Onset and Severity

Thursday, June 21 | 2:30PM - 4:30PM
Workshop 3: Autoimmunity
Room: Saal 4/5

Speaker 4 of 10
Chih-Yeh Chen, Regensburg Center for Interventional Immunology, Germany
Bone Marrow Aire-Expressing Plasma Cells Ectopically Express Tissue-Restricted Self-Antigens and Drive Peripheral Tolerance by Inducing Autoreactive Regulatory T Cells

Thursday, June 21 | 2:30PM - 4:30PM
Workshop 3: Autoimmunity
Room: Saal 4/5

Speaker 5 of 10
Amanda E. Agazio, University of Colorado Anschutz Medical Campus, USA
The Contribution of Anergic B Cells to Protective Immunity

Thursday, June 21 | 2:30PM - 4:30PM
Workshop 3: Autoimmunity
Room: Saal 4/5

Speaker 6 of 10
Carlos Castrillon, Institut Pasteur, France
A Novel Technology to Follow Antibody Affinity Maturation during Autoimmunity

Thursday, June 21 | 2:30PM - 4:30PM
Workshop 3: Autoimmunity
Room: Saal 4/5

Speaker 7 of 10
Roza I. Nurieva, University of Texas MD Anderson Cancer Center, USA
Role of E3 Ubiquitin Ligase GRAIL in B Cell Activation and Tolerance

Thursday, June 21 | 2:30PM - 4:30PM
Workshop 3: Autoimmunity
Room: Saal 4/5

Speaker 8 of 10
Zia Rahman, Penn State Hershey Medical College, USA
Crosstalk between TLR7 and IFNg Signaling via STAT1 in B Cells Controls Spontaneous Germinal Center and Autoimmune Responses

Thursday, June 21 | 2:30PM - 4:30PM
Workshop 3: Autoimmunity
Room: Saal 4/5

Speaker 9 of 10
Jamie van Langelaar, Erasmus University Medical Center, Netherlands
Human T-bet+ B Cells: Induction and Effector Functions from a Multiple Sclerosis Perspective

Thursday, June 21 | 2:30PM - 4:30PM
Workshop 3: Autoimmunity
Room: Saal 4/5

Speaker 10 of 10
Yang Yang, Stanford University School of Medicine, USA
Expression of CTLA4 in B-1 B Cells Acts as A Key Regulating Mechanism in Maintaining the Immune Homeostasis

Thursday, June 21 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, June 21 | 5:00PM - 6:45PM
B Cells in Autoimmune Diseases and Targeting Strategies
Room: Saal 4/5

Speaker 1 of 6
* David M. Tarlinton, Monash University, Australia

Thursday, June 21 | 5:00PM - 6:45PM
B Cells in Autoimmune Diseases and Targeting Strategies
Room: Saal 4/5

Speaker 2 of 6
* Roberta Pelanda, University of Colorado Denver, USA

Thursday, June 21 | 5:00PM - 6:45PM
B Cells in Autoimmune Diseases and Targeting Strategies
Room: Saal 4/5

Speaker 3 of 6
Reinhard E. Voll, University Freiburg, Germany
Targeting Plasma Cells in Systemic Lupus by Proteasome Inhibitors: From Mice to Men

Thursday, June 21 | 5:00PM - 6:45PM
B Cells in Autoimmune Diseases and Targeting Strategies
Room: Saal 4/5

Speaker 4 of 6
Deborah L. Burnett, Garvan Institute of Medical Research, Australia
Short Talk: Antibodies Cross-Reacting with Self and Foreign Proteins Evolve on Consistent Trajectories to Shed Self-Binding, then Enhance Foreign-Binding

Thursday, June 21 | 5:00PM - 6:45PM
B Cells in Autoimmune Diseases and Targeting Strategies
Room: Saal 4/5

Speaker 5 of 6
John C. Cambier, University of Colorado, USA
Loss of Anergy in Human Autoimmunity; Underlying Mechanisms

Thursday, June 21 | 5:00PM - 6:45PM
B Cells in Autoimmune Diseases and Targeting Strategies
Room: Saal 4/5

Speaker 6 of 6
Nicholas Sanderson, University of Basel, Switzerland
Short Talk: High Dimensional Characterization of Cell Phenotypes, Soluble Signaling Molecules and Antibodies in the Cerebrospinal Fluid of Patients with Multiple Sclerosis

Thursday, June 21 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Saal 4/5


Thursday, June 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Terrassen Foyer
No registration fees are used to fund alcohol served at this function.

Thursday, June 21 | 8:00PM - 11:00PM
Entertainment
Room: Terrassen Foyer
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, June 21 | 8:00PM - 11:00PM
Cash Bar
Room: Terrassen Foyer


Friday, June 22 | 10:24AM - 10:24AM
Departure


*Session Chair.