Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Beyond a Million Genomes: From Discovery to Precision Health (2020A4)

Web Desc
One Million Genomes: From Discovery to Health Organizer(s): Geoffrey S. Ginsburg, Teri Manolio and Patrick Boon Ooi Tan Date: June 04 - 08, 2018 Location: Herrenhausen Palace, Hannover, Germany Organized in collaboration with Volkswagen Foundation Sponsored by Regeneron Pharmaceuticals, Inc. and Vertex Pharmaceuticals Incorporated For important information on the coronavirus, please click here Summary of Meeting: The completion of the Human Genome Project in 2003 has catalyzed innovations in scientific research and in healthcare embodied in the term “precision medicine.” Across the globe, many nations are investing in large-scale national sequencing cohort programs, resulting in over one million human genomes sequenced and linked to dense phenotypic and clinical data. This Keystone Symposia conference will bring together scientists and leaders from healthcare and industry to discuss how to maximize the value of that investment for human health. It will assemble a unique and highly interdisciplinary international community to articulate how best to use these data-rich resources to provide novel insights into the biology of disease, tools for the management of patients and population health management strategies. The meeting will highlight challenges and potential solutions for germ-line and somatic sequencing programs and make recommendations for optimizing their impact on global health. The crucial role of free and open sharing and exchange of human variation data from these programs in allowing all of them to interpret novel variants and use them in clinical care will be emphasized. The symposium will focus on various scientific challenges for the field, including implementation science, the scalable data infrastructures and analyses required for impact on discovery and clinical care, and the value proposition for the investments that have been made in national programs. The leading edge of clinical impact of clinical sequencing will be highlighted in sessions on pharmacogenomics, and on developing novel therapeutics. Global Health Travel Award Deadline: January 9 2018 Scholarship Deadline: February 21 2018 Discounted Abstract Deadline: February 21 2018 Abstract Deadline: March 27 2018 Discounted Registration Deadline: April 11 2018 Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested. Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support from these exhibitors at this conference: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: AstraZeneca Fabric Genomics Fabric Genomics Keystone Symposia thanks the Volkswagen Foundation for hosting this conference: Keystone Symposia thanks the following Contributors. We gratefully acknowledge the generous grant for this conference provided by: National Human Genome Research Institute (NHGRI) Grant No. 1 R13 HG009984-01 Funding for this conference was made possible (in part) by 1 R13 HG009984-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

One Million Genomes: From Discovery to Health

Organizer(s): Geoffrey S. Ginsburg, Teri Manolio and Patrick Boon Ooi Tan

Date: June 04 - 08, 2018
Location: Herrenhausen Palace, Hannover, Germany

Organized in collaboration with Volkswagen Foundation
Sponsored by Regeneron Pharmaceuticals, Inc. and Vertex Pharmaceuticals Incorporated

For important information on the coronavirus, please click here

Summary of Meeting:

The completion of the Human Genome Project in 2003 has catalyzed innovations in scientific research and in healthcare embodied in the term “precision medicine.” Across the globe, many nations are investing in large-scale national sequencing cohort programs, resulting in over one million human genomes sequenced and linked to dense phenotypic and clinical data. This Keystone Symposia conference will bring together scientists and leaders from healthcare and industry to discuss how to maximize the value of that investment for human health. It will assemble a unique and highly interdisciplinary international community to articulate how best to use these data-rich resources to provide novel insights into the biology of disease, tools for the management of patients and population health management strategies. The meeting will highlight challenges and potential solutions for germ-line and somatic sequencing programs and make recommendations for optimizing their impact on global health. The crucial role of free and open sharing and exchange of human variation data from these programs in allowing all of them to interpret novel variants and use them in clinical care will be emphasized. The symposium will focus on various scientific challenges for the field, including implementation science, the scalable data infrastructures and analyses required for impact on discovery and clinical care, and the value proposition for the investments that have been made in national programs. The leading edge of clinical impact of clinical sequencing will be highlighted in sessions on pharmacogenomics, and on developing novel therapeutics.

Global Health Travel Award Deadline: January 9 2018

Scholarship Deadline: February 21 2018

Discounted Abstract Deadline: February 21 2018

Abstract Deadline: March 27 2018

Discounted Registration Deadline: April 11 2018

Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support from these exhibitors at this conference:

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

AstraZeneca

Fabric Genomics

Fabric Genomics

Keystone Symposia thanks the Volkswagen Foundation for hosting this conference:

Keystone Symposia thanks the following Contributors.

We gratefully acknowledge the generous grant for this conference provided by:

National Human Genome Research Institute (NHGRI)
Grant No. 1 R13 HG009984-01
Funding for this conference was made possible (in part) by 1 R13 HG009984-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Monday, June 04 \| 4:00PM - 8:00PM Arrival and Registration Room: Grand Mussmann Hotel, Tivoli Room
Monday, June 04 \| 6:00PM - 8:00PM Welcome Mixer Room: Central-Hotel Kaiserhof No registration fees are used to fund alcohol served at this function.
Tuesday, June 05 \| 9:00AM - 10:00AM Welcome and Keynote Address Room: Auditorium Speaker 1 of 2 * Geoffrey S. Ginsburg, Duke University, USA
Tuesday, June 05 \| 9:00AM - 10:00AM Welcome and Keynote Address Room: Auditorium Speaker 2 of 2 Sandi Deans, National Health Service England, UK Delivering Genomic Medicine at a Population Level Across a Health System – The NHS Experience
Tuesday, June 05 \| 10:00AM - 12:30PM Large-Scale National Sequencing Programs: Implementation to Impact Room: Auditorium Speaker 1 of 7 * Geoffrey S. Ginsburg, Duke University, USA
Tuesday, June 05 \| 10:00AM - 12:30PM Large-Scale National Sequencing Programs: Implementation to Impact Room: Auditorium Speaker 2 of 7 Zhengming Chen, University of Oxford, UK China Kadoorie Biobank of 0.5 Million People: Opportunities
Tuesday, June 05 \| 10:00AM - 12:30PM Large-Scale National Sequencing Programs: Implementation to Impact Room: Auditorium Speaker 3 of 7 Andres Metspalu, University of Tartu, Estonia From Biobanking to Precision Medicine
Tuesday, June 05 \| 10:00AM - 12:30PM Large-Scale National Sequencing Programs: Implementation to Impact Room: Auditorium Speaker 4 of 7 Gad Rennert, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Israel Clalit's National Israeli 100K Genomes Personalized Medicine RCT
Tuesday, June 05 \| 10:00AM - 12:30PM Large-Scale National Sequencing Programs: Implementation to Impact Room: Auditorium Coffee Break
Tuesday, June 05 \| 10:00AM - 12:30PM Large-Scale National Sequencing Programs: Implementation to Impact Room: Auditorium Speaker 6 of 7 J. Michael Gaziano, VA Boston Healthcare System, USA The Million Veteran Program: A Modern Mega-Cohort within a Large Healthcare System – Progress, Challenges and Future Directions
Tuesday, June 05 \| 10:00AM - 12:30PM Large-Scale National Sequencing Programs: Implementation to Impact Room: Auditorium Speaker 7 of 7 Mark Jonathan Caulfield, William Harvey Research Institute, Queen Mary University of London, UK Genomics England: The 100,000 Genomes Project
Tuesday, June 05 \| 11:00AM - 11:20AM Poster Setup Room: Ballroom
Tuesday, June 05 \| 12:30PM - 2:00PM Lunch Room: Ballroom
Tuesday, June 05 \| 1:30PM - 7:30PM Poster Viewing Room: Ballroom
Tuesday, June 05 \| 1:30PM - 3:30PM Poster Session 1 Room: Ballroom
Tuesday, June 05 \| 3:30PM - 4:00PM Coffee Available Room: Foyer
Tuesday, June 05 \| 4:00PM - 6:00PM Somatic Sequencing Programs: Biological Insights and Diagnos is Room: Auditorium Speaker 1 of 4 Peter Campbell, Wellcome Trust Sanger Institute, UK Precision Oncology through International Collaboration and Data Sharing
Tuesday, June 05 \| 4:00PM - 6:00PM Somatic Sequencing Programs: Biological Insights and Diagnos is Room: Auditorium Speaker 2 of 4 Pawel Stankiewicz, Baylor College of Medicine, USA New Mutation, Mosaicism and Human Disease Traits
Tuesday, June 05 \| 4:00PM - 6:00PM Somatic Sequencing Programs: Biological Insights and Diagnos is Room: Auditorium Speaker 3 of 4 * Patrick Boon Ooi Tan, Biomedical Research Council, Agency for Science Technology and Research, Singapore Environment, Lifestyle and Genetics: Asian Perspectives and Implications for Precision Medicine
Tuesday, June 05 \| 4:00PM - 6:00PM Somatic Sequencing Programs: Biological Insights and Diagnos is Room: Auditorium Speaker 4 of 4 Adria Jaume Roura Canalda, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Poland Short Talk: Somatic Mutation History of Glioblastoma Patients with Recurrent Tumors
Tuesday, June 05 \| 6:00PM - 7:30PM Social Hour with Lite Bites Room: Ballroom No registration fees are used to fund alcohol served at this function.
Wednesday, June 06 \| 9:00AM - 12:00PM Implementation Science for Genomic and Precision Medicine Room: Auditorium Speaker 1 of 7 * Teri A. Manolio, National Human Genome Research Institute, USA
Wednesday, June 06 \| 9:00AM - 12:00PM Implementation Science for Genomic and Precision Medicine Room: Auditorium Speaker 2 of 7 Robyn L. Ward, University of Queensland, Australia Genomic Test Evaluation Frameworks: A Review
Wednesday, June 06 \| 9:00AM - 12:00PM Implementation Science for Genomic and Precision Medicine Room: Auditorium Speaker 3 of 7 John EL Wong, National University Health System, Singapore Challenges of Precision Medicine Implementation in a High Volume Clinical Environment
Wednesday, June 06 \| 9:00AM - 12:00PM Implementation Science for Genomic and Precision Medicine Room: Auditorium Speaker 4 of 7 Dana C. Crawford, Case Western Reserve University, USA Short Talk: Participating in and Return of Results from Precision Medicine Research: A Survey of Diverse Participants from a Public Hospital in the United States
Wednesday, June 06 \| 9:00AM - 12:00PM Implementation Science for Genomic and Precision Medicine Room: Auditorium Coffee Break
Wednesday, June 06 \| 9:00AM - 12:00PM Implementation Science for Genomic and Precision Medicine Room: Auditorium Speaker 6 of 7 Kathryn North, University of Melbourne, Australia Implementing Genomics into Healthcare: A National and Global Perspective
Wednesday, June 06 \| 9:00AM - 12:00PM Implementation Science for Genomic and Precision Medicine Room: Auditorium Speaker 7 of 7 Geoffrey S. Ginsburg, Duke University, USA A National Network for Implementing Genomic Medicine in Practice (IGNITE)
Wednesday, June 06 \| 9:00AM - 1:30PM Poster Viewing Room: Ballroom
Wednesday, June 06 \| 12:00PM - 1:30PM Lunch Room: Ballroom
Wednesday, June 06 \| 1:30PM - 3:30PM Workshop: Rapid Interpretation of Genomes and Variant Callin g Room: Auditorium Speaker 1 of 6 * Martin G. Reese, Fabric Genomics, USA
Wednesday, June 06 \| 1:30PM - 3:30PM Workshop: Rapid Interpretation of Genomes and Variant Callin g Room: Auditorium Speaker 2 of 6 Atsuko Imai-Okazaki, National Center for Global Health and Medicine, Japan Incorporation of Originally-Developed Statistical Genetics Methods into a Clinical Sequencing Platform to Improve Efficiency and Quality of Variant Annotation
Wednesday, June 06 \| 1:30PM - 3:30PM Workshop: Rapid Interpretation of Genomes and Variant Callin g Room: Auditorium Speaker 3 of 6 Peter Bauer, Centogene AG, Germany Clinical Benefit of Whole Genome Sequencing
Wednesday, June 06 \| 1:30PM - 3:30PM Workshop: Rapid Interpretation of Genomes and Variant Callin g Room: Auditorium Speaker 4 of 6 Lina Ghaloul Gonzalez, University of Pittsburgh School of Medicine, USA Novel Genomics Applications Reveal the Healthcare Eclipse and Lead to Better Clinical Outcomes
Wednesday, June 06 \| 1:30PM - 3:30PM Workshop: Rapid Interpretation of Genomes and Variant Callin g Room: Auditorium Speaker 5 of 6 Natalie Jäger, German Cancer Research Center, Germany Next-Generation Personalized Medicine for High-Risk Paediatric Cancer Patients - The INFORM Registry
Wednesday, June 06 \| 1:30PM - 3:30PM Workshop: Rapid Interpretation of Genomes and Variant Callin g Room: Auditorium Speaker 6 of 6 * Francisco M. De La Vega, Fabric Genomics, Inc., USA You Can't Interpret What You Don't See: Variant Calling from NGS Data for Clinical Applications
Wednesday, June 06 \| 3:30PM - 4:00PM Coffee Available Room: Foyer
Wednesday, June 06 \| 4:00PM - 6:00PM International Data Resources Enabling Genomic Medicine Room: Auditorium Speaker 1 of 4 * Kathryn North, University of Melbourne, Australia
Wednesday, June 06 \| 4:00PM - 6:00PM International Data Resources Enabling Genomic Medicine Room: Auditorium Speaker 2 of 4 Daniel G. MacArthur, Broad Institute, USA Databases for Rare Disease
Wednesday, June 06 \| 4:00PM - 6:00PM International Data Resources Enabling Genomic Medicine Room: Auditorium Speaker 3 of 4 Barbara C. Biedermann, University of Basel, Switzerland Short Talk: COBEDIAS Empiric Clinical Profiling - A Digital Tool to Phenotype Disease
Wednesday, June 06 \| 4:00PM - 6:00PM International Data Resources Enabling Genomic Medicine Room: Auditorium Speaker 4 of 4 Kristjan Metsalu, University of Tartu, Estonia Estonian Healthcare Information System
Wednesday, June 06 \| 6:00PM - 7:30PM Social Hour with Lite Bites Room: Ballroom No registration fees are used to fund alcohol served at this function.
Thursday, June 07 \| 9:00AM - 12:15PM The Actionable Genome Room: Auditorium Speaker 1 of 8 * Geoffrey S. Ginsburg, Duke University, USA
Thursday, June 07 \| 9:00AM - 12:15PM The Actionable Genome Room: Auditorium Speaker 2 of 8 Heidi Rehm, Harvard Medical School, USA The Clinical Genome Resource
Thursday, June 07 \| 9:00AM - 12:15PM The Actionable Genome Room: Auditorium Speaker 3 of 8 James S. Ware, Imperial College London, UK Variation in Cardiac Disease Genes: Location Matters
Thursday, June 07 \| 9:00AM - 12:15PM The Actionable Genome Room: Auditorium Speaker 4 of 8 John R. Giudicessi, Mayo Clinic, USA Short Talk: Synergistic Use of Rare Disease and Public Exome Databases Question the Nature of Minor Non-Syndromic Long QT Syndrome-Susceptibility Gene-Disease Relationships
Thursday, June 07 \| 9:00AM - 12:15PM The Actionable Genome Room: Auditorium Coffee Break
Thursday, June 07 \| 9:00AM - 12:15PM The Actionable Genome Room: Auditorium Speaker 6 of 8 Teri A. Manolio, National Human Genome Research Institute, USA NHGRI/NIH Programs Developing Clinically Actionable Genomic Information
Thursday, June 07 \| 9:00AM - 12:15PM The Actionable Genome Room: Auditorium Speaker 7 of 8 Jill M. Hagenkord, MDisrupt, USA Universal Screening for the CDC Tier 1 Genomic Conditions: Opportunities for Health Systems, Government Health Agencies and Sequencing Initiatives
Thursday, June 07 \| 9:00AM - 12:15PM The Actionable Genome Room: Auditorium Speaker 8 of 8 Franziska Singer, ETH Zurich, Switzerland Short Talk: The Swiss Molecular Tumor Board: Comprehensive Molecular Cancer Diagnostics in the Clinics
Thursday, June 07 \| 10:30AM - 10:50AM Poster Setup Room: Ballroom
Thursday, June 07 \| 12:15PM - 1:45PM Lunch Room: Ballroom
Thursday, June 07 \| 1:30PM - 7:30PM Poster Viewing Room: Ballroom
Thursday, June 07 \| 1:30PM - 3:30PM Poster Session 2 Room: Ballroom
Thursday, June 07 \| 3:30PM - 4:00PM Coffee Available Room: Foyer
Thursday, June 07 \| 4:00PM - 6:15PM The Value Proposition for National Sequencing Room: Auditorium Speaker 1 of 6 * Maja Mockenhaupt, Universitätsklinikum Freiburg, Germany
Thursday, June 07 \| 4:00PM - 6:15PM The Value Proposition for National Sequencing Room: Auditorium Speaker 2 of 6 Lotte Steuten, Fred Hutchinson Cencer Research Center, USA Multiplex NGS Testing in Cancer Care: An Economic Perspective on Hope, Hype and Value
Thursday, June 07 \| 4:00PM - 6:15PM The Value Proposition for National Sequencing Room: Auditorium Speaker 3 of 6 Sarah Wordsworth, University of Oxford, UK The Health Economic Evidence for Whole Genome Sequencing
Thursday, June 07 \| 4:00PM - 6:15PM The Value Proposition for National Sequencing Room: Auditorium Speaker 4 of 6 Surakameth Mahasirimongkol, Ministry of Public Health, Thailand Genomics Thailand: Precision Clinical Care on a National Scale
Thursday, June 07 \| 4:00PM - 6:15PM The Value Proposition for National Sequencing Room: Auditorium Speaker 5 of 6 Nusara Satproedprai, Medical Life Science Institute, Thailand Short Talk: Genomics Thailand: Human Genome Database for Improvement of Health and Medical Services of Thailand
Thursday, June 07 \| 4:00PM - 6:15PM The Value Proposition for National Sequencing Room: Auditorium Speaker 6 of 6 Brett Doble, University of Oxford, UK Short Talk: Using Routinely Collected 'Big Data' to Estimate Healthcare Costs for Rare Disease Patients: An Early Analysis of the UK 100,000 Genomes Project
Thursday, June 07 \| 6:15PM - 7:45PM Social Hour with Lite Bites Room: Ballroom No registration fees are used to fund alcohol served at this function.
Friday, June 08 \| 9:00AM - 12:15PM Pharmacogenomics: The Leading Edge of Genomics Impact in Med icine Room: Auditorium Speaker 1 of 8 * Robyn L. Ward, University of Queensland, Australia
Friday, June 08 \| 9:00AM - 12:15PM Pharmacogenomics: The Leading Edge of Genomics Impact in Med icine Room: Auditorium Speaker 2 of 8 Henk-Jan Guchelaar, Leiden University, Netherlands The Ubiquitous Pharmacogenomics Project
Friday, June 08 \| 9:00AM - 12:15PM Pharmacogenomics: The Leading Edge of Genomics Impact in Med icine Room: Auditorium Speaker 3 of 8 Mary V. Relling, St. Jude Children's Hospital, USA Clinical Implementation of Pharmacogenetics
Friday, June 08 \| 9:00AM - 12:15PM Pharmacogenomics: The Leading Edge of Genomics Impact in Med icine Room: Auditorium Speaker 4 of 8 Gabor Marth, University of Utah, USA Short Talk: Precision Oncology of Advanced Disease: Insights into Refractory and Metastatic Cancers
Friday, June 08 \| 9:00AM - 12:15PM Pharmacogenomics: The Leading Edge of Genomics Impact in Med icine Room: Auditorium Coffee Break
Friday, June 08 \| 9:00AM - 12:15PM Pharmacogenomics: The Leading Edge of Genomics Impact in Med icine Room: Auditorium Speaker 6 of 8 Maja Mockenhaupt, Universitätsklinikum Freiburg, Germany Using Genetics to Prevent Stevens Johnson Syndrome/Toxic Epidermal Necrolysis
Friday, June 08 \| 9:00AM - 12:15PM Pharmacogenomics: The Leading Edge of Genomics Impact in Med icine Room: Auditorium Speaker 7 of 8 Jianjun Liu, Genome Institute of Singapore, Singapore The SaPHIRE Program – Enabling Adverse Drug Reaction Research in Real Time
Friday, June 08 \| 9:00AM - 12:15PM Pharmacogenomics: The Leading Edge of Genomics Impact in Med icine Room: Auditorium Speaker 8 of 8 Folefac Aminkeng, National University of Singapore/ Agency for Science, Technology & Research, Singapore Short Talk: A missense variant of HFE is associated with Bleomycin-induced Lung Injury in South East Asian Hodgkin Lymphoma Patients
Friday, June 08 \| 9:00AM - 1:45PM Poster Viewing Room: Ballroom
Friday, June 08 \| 12:15PM - 1:45PM Lunch Room: Ballroom
Friday, June 08 \| 3:30PM - 4:00PM Coffee Available Room: Foyer
Friday, June 08 \| 4:00PM - 6:15PM Use of Large-Scale Bio-Clinical Resources for Drug Discovery Room: Auditorium Speaker 1 of 5 * Henk-Jan Guchelaar, Leiden University, Netherlands
Friday, June 08 \| 4:00PM - 6:15PM Use of Large-Scale Bio-Clinical Resources for Drug Discovery Room: Auditorium Speaker 2 of 5 Alan R. Shuldiner, Regeneron Pharmaceuticals, Inc, USA Discovery of Novel Drug Targets: High-Throughput Genomics of 250,000 Exomes
Friday, June 08 \| 4:00PM - 6:15PM Use of Large-Scale Bio-Clinical Resources for Drug Discovery Room: Auditorium Speaker 3 of 5 Carolina Haefliger, AstraZeneca, Sweden Transforming Drug Research and Development with Genomics
Friday, June 08 \| 4:00PM - 6:15PM Use of Large-Scale Bio-Clinical Resources for Drug Discovery Room: Auditorium Speaker 4 of 5 Jeong-Sun Seo, Seoul National University Bundang Hospital and Macrogen, South Korea GenomeAsia 100K (GA100K) and Asian Reference Genome
Friday, June 08 \| 4:00PM - 6:15PM Use of Large-Scale Bio-Clinical Resources for Drug Discovery Room: Auditorium Speaker 5 of 5 Martin G. Reese, Fabric Genomics, USA Accurate and Rapid WGS Interpretation – In Clinical Care
Friday, June 08 \| 6:15PM - 6:30PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Auditorium
Friday, June 08 \| 6:30PM - 8:00PM Social Hour with Lite Bites Room: Ballroom No registration fees are used to fund alcohol served at this function.
Saturday, June 09 \| 10:24AM - 10:24AM Departure *Session Chair †Invited, not yet responded.