Web Desc
Organ Crosstalk in Obesity and NAFLD
joint with Bioenergetics and Metabolic Disease
Organizer(s): Gary J. Schwartz, Bei B. Zhang and Christoph Buettner
Date: January 21 - 25, 2018
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Novo Nordisk A/S
For important information on the coronavirus, please click here
Summary of Meeting:
Neural and humoral communication among peripheral organs and the brain is critical in coordinating whole body energy homeostasis in health and disease. Nutrient and hormone sensing take place in multiple organs with the central nervous system as a site of integration of these diverse signals, governing this coordination. Within this multi-organ framework, the liver occupies a central role in determining systemic glucose and lipid metabolism in obesity and clinically relevant metabolic pathophysiology, particularly non-alcoholic fatty liver disease (NAFLD) and fibrosis. Identification and characterization of the modes and consequences of organ cross-talk is essential to fill existing gaps in knowledge and to promote the development of therapeutic strategies to treat obesity and metabolic disease. This conference brings together experts in the novel, multidisciplinary evaluation of organ cross-talk, using innovative combinations of molecular, genetic, physiological, pharmacological and systems neuroscience approaches to: 1) Provide a unique and timely perspective, and 2) Inspire interactions directed toward basic, clinical and translational research in integrative metabolism. Finally, the joint staging of this conference in conjunction with the conference on “Bioenergetics and Metabolic Disease” will strategically leverage presentations targeting the biology of metabolism and nutrient availability in obesity with those focused on the biology of energy utilization. Taken together, this novel combination will provide a coherent, powerful and comprehensive understanding of and appreciation for the complex.
Scholarship Deadline: September 28 2017
Discounted Abstract Deadline: September 28 2017
Abstract Deadline: October 26 2017
Discounted Registration Deadline: November 29 2017
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Novo Nordisk A/S
We gratefully acknowledge additional support from these exhibitors at this conference:
Mercodia, Inc.
We gratefully acknowledge additional support for this conference from:
Adipogen InternationalALPCOInSphero Inc.Research Diets, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Janssen R&D: Pharmaceutical Companies of Johnson & Johnson

Pfizer Research Technology Center
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK104611-04
Funding for this conference was made possible (in part) by 5R13DK104611-04 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 21 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, January 21 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Monday, January 22 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom
This lecture will provide a broad introduction to the central control of various metabolic parameters.
Speaker 1 of 3
* Gary J. Schwartz, Albert Einstein College of Medicine, USA

Monday, January 22 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom
This lecture will provide a broad introduction to the central control of various metabolic parameters.
Speaker 2 of 3
* Patrick Seale, University of Pennsylvania, USA

Monday, January 22 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom
This lecture will provide a broad introduction to the central control of various metabolic parameters.
Speaker 3 of 3
Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany
Control of Integrative Physiology by the Melanocortin Circuitry

Monday, January 22 | 9:00AM - 11:30AM
Central Modulation of Metabolism (Joint)
Room: Columbine Ballroom
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.
Speaker 1 of 8
* Gary J. Schwartz, Albert Einstein College of Medicine, USA

Monday, January 22 | 9:00AM - 11:30AM
Central Modulation of Metabolism (Joint)
Room: Columbine Ballroom
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.
Speaker 2 of 8
* Gregory James Morton, University of Washington, USA

Monday, January 22 | 9:00AM - 11:30AM
Central Modulation of Metabolism (Joint)
Room: Columbine Ballroom
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.
Speaker 3 of 8
Matthew R. Hayes, University of Pennsylvania, USA
Metabolic Neuropeptides as Modulators of Energy Balance, Motivation and Reward

Monday, January 22 | 9:00AM - 11:30AM
Central Modulation of Metabolism (Joint)
Room: Columbine Ballroom
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.

Coffee Break

Monday, January 22 | 9:00AM - 11:30AM
Central Modulation of Metabolism (Joint)
Room: Columbine Ballroom
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.
Speaker 5 of 8
Xiaoyong Yang, Yale University School of Medicine, USA
Short Talk: O-GlcNAc Signaling in Central Nutrient Sensing and Brain-Fat-Liver Communication

Monday, January 22 | 9:00AM - 11:30AM
Central Modulation of Metabolism (Joint)
Room: Columbine Ballroom
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.
Speaker 6 of 8
Christoph Buettner, Mount Sinai School of Medicine, USA
Brain Control of Adipose Tissue Functionality as a Determinant of Hypothalamic and Liver Function

Monday, January 22 | 9:00AM - 11:30AM
Central Modulation of Metabolism (Joint)
Room: Columbine Ballroom
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.
Speaker 7 of 8
Daniel L. Marks, Oregon Health & Science University, USA
Central Mechanisms in Cancer Cachexia

Monday, January 22 | 9:00AM - 11:30AM
Central Modulation of Metabolism (Joint)
Room: Columbine Ballroom
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.
Speaker 8 of 8
Bernard B. Allan, NGM Biopharmaceuticals, USA
Short Talk: GDF15 Induces Cancer Anorexia and Cachexia through GFRAL-dependent Activation of Neuronal Circuitry

Monday, January 22 | 11:30AM - 5:00PM
On Own for Lunch


Monday, January 22 | 11:30AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Monday, January 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Monday, January 22 | 2:30PM - 4:30PM
Workshop 1: Emerging Therapeutic Targets for Metabolic Disea
se (Joint)
Room: Columbine Ballroom

Speaker 1 of 9
* Cecile Vernochet, Pfizer, USA

Monday, January 22 | 2:30PM - 4:30PM
Workshop 1: Emerging Therapeutic Targets for Metabolic Disea
se (Joint)
Room: Columbine Ballroom

Speaker 2 of 9
* Shamina M. Rangwala, Pfizer, USA

Monday, January 22 | 2:30PM - 4:30PM
Workshop 1: Emerging Therapeutic Targets for Metabolic Disea
se (Joint)
Room: Columbine Ballroom

Speaker 3 of 9
Philipa Levesque-Damphousse, Institut de Recherches Cliniques de Montréal, Canada
SerpinA3N, an Early Biomarker of Non-Alcoholic Fatty Liver Disease

Monday, January 22 | 2:30PM - 4:30PM
Workshop 1: Emerging Therapeutic Targets for Metabolic Disea
se (Joint)
Room: Columbine Ballroom

Speaker 4 of 9
Majid Mufaqam Syed-Abdul, University of Missouri, USA
Progressive Reductions in Hepatic DNL with Increasing Doses of TVB-2640, a First-in-Class Pharmacologic Inhibitor of FASN

Monday, January 22 | 2:30PM - 4:30PM
Workshop 1: Emerging Therapeutic Targets for Metabolic Disea
se (Joint)
Room: Columbine Ballroom

Speaker 5 of 9
Senad Divanovic, Cincinnati Children's Hospital Medical Center, USA
Metabolic Reprogramming of Th17 Cells Regulates Inflammatory Vigor and NAFLD Pathogenesis

Monday, January 22 | 2:30PM - 4:30PM
Workshop 1: Emerging Therapeutic Targets for Metabolic Disea
se (Joint)
Room: Columbine Ballroom

Speaker 6 of 9
Joe S. Grimsby, AstraZeneca, USA
GLP-1R/GCGR Dual Agonist Reduced Obesity by Increasing Energy Expenditure due to its Effects in Brown Adipose Tissue and Browning of White Fat

Monday, January 22 | 2:30PM - 4:30PM
Workshop 1: Emerging Therapeutic Targets for Metabolic Disea
se (Joint)
Room: Columbine Ballroom

Speaker 7 of 9
Hyeonwoo Kim, Dana-Farber Cancer Institute/Harvard Medical School, USA
Identification of the Irisin Receptor and its Role in Exercise

Monday, January 22 | 2:30PM - 4:30PM
Workshop 1: Emerging Therapeutic Targets for Metabolic Disea
se (Joint)
Room: Columbine Ballroom

Speaker 8 of 9
Brian N. Finck, Washington University School of Medicine, USA
Identification of Mitochondrial Pyruvate Carrier Modulators to Treat Diabetes and NAFLD

Monday, January 22 | 2:30PM - 4:30PM
Workshop 1: Emerging Therapeutic Targets for Metabolic Disea
se (Joint)
Room: Columbine Ballroom

Speaker 9 of 9
Monica Dentice, Università degli Studi di Napoli Federico II, Italy
Muscle-Specific Action of Deiodinases Induces Metabolic Switches in Muscle thereby Influencing Systemic Energy Metabolism

Monday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 22 | 5:00PM - 7:00PM
Sweet Spots in the Brain: Central Glucose Sensing and Periph
eral Glucose Homeostasis

Room: Grays/Longs Peak

Speaker 1 of 6
* Christoph Buettner, Mount Sinai School of Medicine, USA

Monday, January 22 | 5:00PM - 7:00PM
Sweet Spots in the Brain: Central Glucose Sensing and Periph
eral Glucose Homeostasis

Room: Grays/Longs Peak

Speaker 2 of 6
* Zachary A. Knight, University of California, San Francisco, USA

Monday, January 22 | 5:00PM - 7:00PM
Sweet Spots in the Brain: Central Glucose Sensing and Periph
eral Glucose Homeostasis

Room: Grays/Longs Peak

Speaker 3 of 6
Sarah Stanley, Icahn School of Medicine at Mount Sinai, USA
New Tools to Study the Role of Glucose-Sensing Neurons

Monday, January 22 | 5:00PM - 7:00PM
Sweet Spots in the Brain: Central Glucose Sensing and Periph
eral Glucose Homeostasis

Room: Grays/Longs Peak

Speaker 4 of 6
Gregory James Morton, University of Washington, USA
CNS Mechanisms Governing Diabetic Hyperglycemia

Monday, January 22 | 5:00PM - 7:00PM
Sweet Spots in the Brain: Central Glucose Sensing and Periph
eral Glucose Homeostasis

Room: Grays/Longs Peak

Speaker 5 of 6
Greg S. B. Suh, New York University School of Medicine, USA
Feeding and Nutrient Sensing in Flies and Mice

Monday, January 22 | 5:00PM - 7:00PM
Sweet Spots in the Brain: Central Glucose Sensing and Periph
eral Glucose Homeostasis

Room: Grays/Longs Peak

Speaker 6 of 6
Eleni Rebelos, Turku University, Finland
Short Talk: Brain-Liver-Pancreas Axis Revised with FDG-PET Imaging

Monday, January 22 | 5:00PM - 7:00PM
Brown and Beige Fat Thermogenesis
This session is from Bioenergetics
Room: Quandary Peak
Discuss mechanisms that control the development and thermogenic function of brown and beige fat.
Speaker 1 of 6
* Jan Nedergaard, Stockholm University, Sweden


Monday, January 22 | 5:00PM - 7:00PM
Brown and Beige Fat Thermogenesis
This session is from Bioenergetics
Room: Quandary Peak
Discuss mechanisms that control the development and thermogenic function of brown and beige fat.
Speaker 2 of 6
* Kristy L. Townsend, University of Maine, USA


Monday, January 22 | 5:00PM - 7:00PM
Brown and Beige Fat Thermogenesis
This session is from Bioenergetics
Room: Quandary Peak
Discuss mechanisms that control the development and thermogenic function of brown and beige fat.
Speaker 3 of 6
Patrick Seale, University of Pennsylvania, USA
Molecular Regulation of Brown and Beige Adipogenesis


Monday, January 22 | 5:00PM - 7:00PM
Brown and Beige Fat Thermogenesis
This session is from Bioenergetics
Room: Quandary Peak
Discuss mechanisms that control the development and thermogenic function of brown and beige fat.
Speaker 4 of 6
Sheila Collins, Vanderbilt University Medical Center, USA
Receptor Systems and Signaling Mechanisms in White and Brown
Adipocytes


Monday, January 22 | 5:00PM - 7:00PM
Brown and Beige Fat Thermogenesis
This session is from Bioenergetics
Room: Quandary Peak
Discuss mechanisms that control the development and thermogenic function of brown and beige fat.
Speaker 5 of 6
Evan D. Rosen, Harvard University, USA
Epigenomic Characterization of Beige Adipocyte Plasticity


Monday, January 22 | 5:00PM - 7:00PM
Brown and Beige Fat Thermogenesis
This session is from Bioenergetics
Room: Quandary Peak
Discuss mechanisms that control the development and thermogenic function of brown and beige fat.
Speaker 6 of 6
Zach Gerhart-Hines, University of Copenhagen, Denmark
Short Talk: Cardiolipin Synthesis Governs Systemic Energy Homeostasis through Thermogenic Fat Mitochondria


Monday, January 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, January 22 | 7:30PM - 10:00PM
Poster Session 1
Room: Colorado Rockies Ballroom


Tuesday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Tuesday, January 23 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 1 of 2
* Patrick Seale, University of Pennsylvania, USA

Tuesday, January 23 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 2 of 2
Bruce M. Spiegelman, Harvard Medical School, USA
Pathways that Control Cellular and Organismal Energy Metabolism

Tuesday, January 23 | 9:00AM - 11:30AM
Adipose Plasticity and Metabolism (Joint)
Room: Columbine Ballroom
Evaluate how adipose tissue function and dysfunction influences systemic metabolism.
Speaker 1 of 8
* Barbara Cannon, Stockholm University, Sweden

Tuesday, January 23 | 9:00AM - 11:30AM
Adipose Plasticity and Metabolism (Joint)
Room: Columbine Ballroom
Evaluate how adipose tissue function and dysfunction influences systemic metabolism.
Speaker 2 of 8
* Li Qiang, Columbia University Medical Center, USA

Tuesday, January 23 | 9:00AM - 11:30AM
Adipose Plasticity and Metabolism (Joint)
Room: Columbine Ballroom
Evaluate how adipose tissue function and dysfunction influences systemic metabolism.
Speaker 3 of 8
Susan K. Fried, Icahn School of Medicine at Mount Sinai, USA
Sex- and Depot- Dependent Mechanisms Shaping Fat Distribution and Metabolic Health

Tuesday, January 23 | 9:00AM - 11:30AM
Adipose Plasticity and Metabolism (Joint)
Room: Columbine Ballroom
Evaluate how adipose tissue function and dysfunction influences systemic metabolism.

Coffee Break

Tuesday, January 23 | 9:00AM - 11:30AM
Adipose Plasticity and Metabolism (Joint)
Room: Columbine Ballroom
Evaluate how adipose tissue function and dysfunction influences systemic metabolism.
Speaker 5 of 8
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipose Fibrosis in Metabolic Regulation

Tuesday, January 23 | 9:00AM - 11:30AM
Adipose Plasticity and Metabolism (Joint)
Room: Columbine Ballroom
Evaluate how adipose tissue function and dysfunction influences systemic metabolism.
Speaker 6 of 8
Su Myung Jung, University of Massachusetts Medical School, USA
Short Talk: A Non-Canonical mTORC2 Signaling Pathway that Regulates Thermogenesis

Tuesday, January 23 | 9:00AM - 11:30AM
Adipose Plasticity and Metabolism (Joint)
Room: Columbine Ballroom
Evaluate how adipose tissue function and dysfunction influences systemic metabolism.
Speaker 7 of 8
Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Control of Systemic Metabolism by de novo Lipogenesis in Adipose

Tuesday, January 23 | 9:00AM - 11:30AM
Adipose Plasticity and Metabolism (Joint)
Room: Columbine Ballroom
Evaluate how adipose tissue function and dysfunction influences systemic metabolism.
Speaker 8 of 8
Paul Cohen, Rockefeller University, USA
Short Talk: Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density

Tuesday, January 23 | 11:30AM - 5:00PM
On Own for Lunch


Tuesday, January 23 | 11:30AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Tuesday, January 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Tuesday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 23 | 5:00PM - 7:00PM
Hepatic Metabolism in Obesity
Room: Grays/Longs Peak

Speaker 1 of 6
* Bei B. Zhang, Pfizer Inc., USA

Tuesday, January 23 | 5:00PM - 7:00PM
Hepatic Metabolism in Obesity
Room: Grays/Longs Peak

Speaker 2 of 6
* Rebecca A. Haeusler, Columbia University, USA

Tuesday, January 23 | 5:00PM - 7:00PM
Hepatic Metabolism in Obesity
Room: Grays/Longs Peak

Speaker 3 of 6
Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Compartmentalization of Hepatic Lipid Metabolism

Tuesday, January 23 | 5:00PM - 7:00PM
Hepatic Metabolism in Obesity
Room: Grays/Longs Peak

Speaker 4 of 6
Morris J. Birnbaum, Pfizer Inc., USA
Regulation of Hepatic Lipid Accumulation

Tuesday, January 23 | 5:00PM - 7:00PM
Hepatic Metabolism in Obesity
Room: Grays/Longs Peak

Speaker 5 of 6
Baoliang Song, Wuhan University, China
New Explorations on the Ancient Cholesterol Molecule

Tuesday, January 23 | 5:00PM - 7:00PM
Hepatic Metabolism in Obesity
Room: Grays/Longs Peak

Speaker 6 of 6
Chaofeng Yang, University of Texas Southwestern Medical Center, USA
Short Talk: Plin5 Is a Key Regulator of Lipid and Glucose Metabolism in the Liver

Tuesday, January 23 | 5:00PM - 7:00PM
Mitochondria: Form and Function
This session is from Bioenergetics
Room: Quandary Peak
Discuss key concepts and mechanisms involved in controlling mitochondrial dynamics and energetics.
Speaker 1 of 6
* P. Darrell Neufer, East Carolina University, USA


Tuesday, January 23 | 5:00PM - 7:00PM
Mitochondria: Form and Function
This session is from Bioenergetics
Room: Quandary Peak
Discuss key concepts and mechanisms involved in controlling mitochondrial dynamics and energetics.
Speaker 2 of 6
* Zhidan Wu, Pfizer, USA


Tuesday, January 23 | 5:00PM - 7:00PM
Mitochondria: Form and Function
This session is from Bioenergetics
Room: Quandary Peak
Discuss key concepts and mechanisms involved in controlling mitochondrial dynamics and energetics.
Speaker 3 of 6
Jodi Nunnari, University of California, Davis, USA
Mitochondrial Behavior


Tuesday, January 23 | 5:00PM - 7:00PM
Mitochondria: Form and Function
This session is from Bioenergetics
Room: Quandary Peak
Discuss key concepts and mechanisms involved in controlling mitochondrial dynamics and energetics.
Speaker 4 of 6
Mary-Ellen Harper, University of Ottawa, Canada
Acute Control of the Uncoupling Proteins: Redox, ROS Feedback Loops and Post-Translational Modifications


Tuesday, January 23 | 5:00PM - 7:00PM
Mitochondria: Form and Function
This session is from Bioenergetics
Room: Quandary Peak
Discuss key concepts and mechanisms involved in controlling mitochondrial dynamics and energetics.
Speaker 5 of 6
Erin Leah Seifert, Thomas Jefferson University, USA
Short Talk: Loss of Mitochondrial Phosphate Carrier in Skeletal Muscle: Dissociation of Muscle Dysfunction from Lower ADP Phosphorylating Potential


Tuesday, January 23 | 5:00PM - 7:00PM
Mitochondria: Form and Function
This session is from Bioenergetics
Room: Quandary Peak
Discuss key concepts and mechanisms involved in controlling mitochondrial dynamics and energetics.
Speaker 6 of 6
Daniel P. Kelly, University of Pennsylvania, USA
Transcriptional Control of Mitochondrial Fuel Metabolism


Tuesday, January 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, January 23 | 7:30PM - 10:00PM
Poster Session 2
Room: Colorado Rockies Ballroom


Wednesday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Wednesday, January 24 | 8:00AM - 11:00AM
Hepatic Dysfunction in NASH and NAFLD
Room: Grays/Longs Peak

Speaker 1 of 8
* Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA

Wednesday, January 24 | 8:00AM - 11:00AM
Hepatic Dysfunction in NASH and NAFLD
Room: Grays/Longs Peak

Speaker 2 of 8
* Utpal B. Pajvani, Columbia University Medical Center, USA

Wednesday, January 24 | 8:00AM - 11:00AM
Hepatic Dysfunction in NASH and NAFLD
Room: Grays/Longs Peak

Speaker 3 of 8
Gyongyi Szabo, University of Massachusetts Medical School, USA
Inflammasome Activation Pathways in NAFLD and NASH

Wednesday, January 24 | 8:00AM - 11:00AM
Hepatic Dysfunction in NASH and NAFLD
Room: Grays/Longs Peak

Speaker 4 of 8
Samuel Klein, Washington University School of Medicine, USA
Biochemical, Metabolic and Clinical Implications in Obesity and NASH

Wednesday, January 24 | 8:00AM - 11:00AM
Hepatic Dysfunction in NASH and NAFLD
Room: Grays/Longs Peak


Coffee Break

Wednesday, January 24 | 8:00AM - 11:00AM
Hepatic Dysfunction in NASH and NAFLD
Room: Grays/Longs Peak

Speaker 6 of 8
Gerald I. Shulman, Yale University School of Medicine, USA
Targeting Mitochondria to Treat NAFLD, NASH and Type 2 Diabetes

Wednesday, January 24 | 8:00AM - 11:00AM
Hepatic Dysfunction in NASH and NAFLD
Room: Grays/Longs Peak

Speaker 7 of 8
Elizabeth J. Parks, University of Missouri, USA
Drug Development in NAFLD: From Lipogenesis to Fibrosis

Wednesday, January 24 | 8:00AM - 11:00AM
Hepatic Dysfunction in NASH and NAFLD
Room: Grays/Longs Peak

Speaker 8 of 8
Anna Laitakari, University of Oulu, Finland
Short Talk: Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects against Fatty Liver Disease and Metabolic Dysfunction in Mice

Wednesday, January 24 | 8:00AM - 11:00AM
Energy Expenditure and Body Weight Regulation in Humans
This session is from Bioenergetics
Room: Quandary Peak
Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency.
Speaker 1 of 8
* Alexander S. Banks, Harvard Medical School, USA


Wednesday, January 24 | 8:00AM - 11:00AM
Energy Expenditure and Body Weight Regulation in Humans
This session is from Bioenergetics
Room: Quandary Peak
Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency.
Speaker 2 of 8
* Anna Krook, Karolinska Institutet, Sweden


Wednesday, January 24 | 8:00AM - 11:00AM
Energy Expenditure and Body Weight Regulation in Humans
This session is from Bioenergetics
Room: Quandary Peak
Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency.
Speaker 3 of 8
Herman Pontzer, Hunter College, USA
Evolutionary Origins of Obesity


Wednesday, January 24 | 8:00AM - 11:00AM
Energy Expenditure and Body Weight Regulation in Humans
This session is from Bioenergetics
Room: Quandary Peak
Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency.
Speaker 4 of 8
Michael Rosenbaum, Columbia University Medical College, USA
Regulation of Energy Balance following Weight Reduction


Wednesday, January 24 | 8:00AM - 11:00AM
Energy Expenditure and Body Weight Regulation in Humans
This session is from Bioenergetics
Room: Quandary Peak
Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency.

Coffee Break


Wednesday, January 24 | 8:00AM - 11:00AM
Energy Expenditure and Body Weight Regulation in Humans
This session is from Bioenergetics
Room: Quandary Peak
Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency.
Speaker 6 of 8
Wouter D. van Marken Lichtenbelt, Maastricht University, Netherlands
Cold Exposure and Metabolic Health: Role Brown Adipose Tissue and Skeletal Muscle


Wednesday, January 24 | 8:00AM - 11:00AM
Energy Expenditure and Body Weight Regulation in Humans
This session is from Bioenergetics
Room: Quandary Peak
Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency.
Speaker 7 of 8
Denis P. Blondin, University of Sherbrooke, Canada
Short Talk: White Adipose Tissue Lipolysis Not Just a Fuel Supply: Re-Visiting the Significant Thermogenic Contribution of the Triglyceride-Fatty Acid Cycle in Humans Exposed to the Cold or Stimulated with a ß3-Adrenergic Receptor Agonist (Mirabegron


Wednesday, January 24 | 8:00AM - 11:00AM
Energy Expenditure and Body Weight Regulation in Humans
This session is from Bioenergetics
Room: Quandary Peak
Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency.
Speaker 8 of 8
Steven R. Smith, AdventHealth, USA
Metabolic Flexibility and Energy Utilization


Wednesday, January 24 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, January 24 | 11:00AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Wednesday, January 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Wednesday, January 24 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 24 | 5:00PM - 7:00PM
The Many Scars of Obesity: Systemic Fibrosis and Hypothalami
c Gliosis

Room: Grays/Longs Peak

Speaker 1 of 6
* Kendra K. Bence, Pfizer Inc., USA

Wednesday, January 24 | 5:00PM - 7:00PM
The Many Scars of Obesity: Systemic Fibrosis and Hypothalami
c Gliosis

Room: Grays/Longs Peak

Speaker 2 of 6
* Suneil K. Koliwad, University of California, San Francisco, USA

Wednesday, January 24 | 5:00PM - 7:00PM
The Many Scars of Obesity: Systemic Fibrosis and Hypothalami
c Gliosis

Room: Grays/Longs Peak

Speaker 3 of 6
Bart Staels, Institut Pasteur de Lille, Université Lille, France
Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease

Wednesday, January 24 | 5:00PM - 7:00PM
The Many Scars of Obesity: Systemic Fibrosis and Hypothalami
c Gliosis

Room: Grays/Longs Peak

Speaker 4 of 6
Joshua Thaler, University of Washington, USA
Hypothalamic Gliosis

Wednesday, January 24 | 5:00PM - 7:00PM
The Many Scars of Obesity: Systemic Fibrosis and Hypothalami
c Gliosis

Room: Grays/Longs Peak

Speaker 5 of 6
Ana Domingos, University of Oxford, UK
Sympathetic Neuroimmunity for Obesity

Wednesday, January 24 | 5:00PM - 7:00PM
The Many Scars of Obesity: Systemic Fibrosis and Hypothalami
c Gliosis

Room: Grays/Longs Peak

Speaker 6 of 6
Utpal B. Pajvani, Columbia University Medical Center, USA
Short Talk: Notch Mediates Hepatocyte-HSC Crosstalk to Induce Fibrosis in NASH

Wednesday, January 24 | 5:00PM - 7:00PM
Cellular Regulators of Bioenergetics
This session is from Bioenergetics
Room: Quandary Peak
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.
Speaker 1 of 6
* Deborah M. Muoio, Duke University Medical Center, USA


Wednesday, January 24 | 5:00PM - 7:00PM
Cellular Regulators of Bioenergetics
This session is from Bioenergetics
Room: Quandary Peak
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.
Speaker 2 of 6
* Jorge L. Ruas, Karolinska Institutet, Sweden


Wednesday, January 24 | 5:00PM - 7:00PM
Cellular Regulators of Bioenergetics
This session is from Bioenergetics
Room: Quandary Peak
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.
Speaker 3 of 6
P. Darrell Neufer, East Carolina University, USA
Redox Circuit Flux and Energy Expenditure


Wednesday, January 24 | 5:00PM - 7:00PM
Cellular Regulators of Bioenergetics
This session is from Bioenergetics
Room: Quandary Peak
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.
Speaker 4 of 6
Muthu Periasamy, University of Central Florida, USA
Skeletal Muscle-Based Thermogenic Mechanisms


Wednesday, January 24 | 5:00PM - 7:00PM
Cellular Regulators of Bioenergetics
This session is from Bioenergetics
Room: Quandary Peak
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.
Speaker 5 of 6
Edward T. Chouchani, Dana-Farber Cancer Institute, USA
Short Talk: A Novel Molecular Pathway Controls Acute Activation of Adipose Tissue Thermogenesis


Wednesday, January 24 | 5:00PM - 7:00PM
Cellular Regulators of Bioenergetics
This session is from Bioenergetics
Room: Quandary Peak
Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis.
Speaker 6 of 6
Daniel Garcia, The Salk Institute for Biological Studies, USA
AMPK Control of Cellular Energetics


Wednesday, January 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, January 24 | 7:30PM - 10:00PM
Poster Session 3
Room: Colorado Rockies Ballroom


Thursday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Thursday, January 25 | 7:30AM - 8:00AM
Poster Setup
Room: Colorado Rockies Ballroom


Thursday, January 25 | 8:00AM - 5:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Thursday, January 25 | 8:00AM - 11:00AM
Feel Your Gut: The Gut-Brain-Food Connection
Room: Grays/Longs Peak

Speaker 1 of 8
* Elizabeth J. Parks, University of Missouri, USA

Thursday, January 25 | 8:00AM - 11:00AM
Feel Your Gut: The Gut-Brain-Food Connection
Room: Grays/Longs Peak

Speaker 2 of 8
* Thomas Alexander Lutz, University of Zürich, Switzerland

Thursday, January 25 | 8:00AM - 11:00AM
Feel Your Gut: The Gut-Brain-Food Connection
Room: Grays/Longs Peak

Speaker 3 of 8
Zachary A. Knight, University of California, San Francisco, USA
Nutritional Regulation of Hunger Circuits

Thursday, January 25 | 8:00AM - 11:00AM
Feel Your Gut: The Gut-Brain-Food Connection
Room: Grays/Longs Peak

Speaker 4 of 8
Kendra K. Bence, Pfizer Inc., USA
Targeting Fructose Metabolism for the Treatment of NAFLD/NASH

Thursday, January 25 | 8:00AM - 11:00AM
Feel Your Gut: The Gut-Brain-Food Connection
Room: Grays/Longs Peak


Coffee Break

Thursday, January 25 | 8:00AM - 11:00AM
Feel Your Gut: The Gut-Brain-Food Connection
Room: Grays/Longs Peak

Speaker 6 of 8
Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute, Canada
Gut Peptides Drive Metabolic Organs: Direct vs. Indirect Mechanisms

Thursday, January 25 | 8:00AM - 11:00AM
Feel Your Gut: The Gut-Brain-Food Connection
Room: Grays/Longs Peak

Speaker 7 of 8
Mark D. Erion, Janssen Pharmaceuticals, USA
Approaches Targeting Metabolic Control and Weight Management – From Mice to Man

Thursday, January 25 | 8:00AM - 11:00AM
Feel Your Gut: The Gut-Brain-Food Connection
Room: Grays/Longs Peak

Speaker 8 of 8
Nicholas Vincent DiPatrizio, University of California, Riverside, School of Medicine, USA
Short Talk: Endocannabinoids Inhibit Gut-Brain Satiation Signaling in Obesity

Thursday, January 25 | 8:00AM - 11:00AM
Skeletal Muscle: Use and Disuse
This session is from Bioenergetics
Room: Quandary Peak
The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia.
Speaker 1 of 8
* Bruce M. Spiegelman, Harvard Medical School, USA


Thursday, January 25 | 8:00AM - 11:00AM
Skeletal Muscle: Use and Disuse
This session is from Bioenergetics
Room: Quandary Peak
The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia.
Speaker 2 of 8
* Erin Leah Seifert, Thomas Jefferson University, USA


Thursday, January 25 | 8:00AM - 11:00AM
Skeletal Muscle: Use and Disuse
This session is from Bioenergetics
Room: Quandary Peak
The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia.
Speaker 3 of 8
Juleen R. Zierath, Karolinska Institutet, Sweden
Epigenetic Control and the Circadian Clock: Turning Back Time on Diabetes Pathogenesis


Thursday, January 25 | 8:00AM - 11:00AM
Skeletal Muscle: Use and Disuse
This session is from Bioenergetics
Room: Quandary Peak
The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia.
Speaker 4 of 8
David E. James, University of Sydney, Australia
Probing the Exercise Regulated Phosphoproteome in Skeletal Muscle


Thursday, January 25 | 8:00AM - 11:00AM
Skeletal Muscle: Use and Disuse
This session is from Bioenergetics
Room: Quandary Peak
The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia.

Coffee Break


Thursday, January 25 | 8:00AM - 11:00AM
Skeletal Muscle: Use and Disuse
This session is from Bioenergetics
Room: Quandary Peak
The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia.
Speaker 6 of 8
Deborah M. Muoio, Duke University Medical Center, USA
Adaptive Responses to Exercise Controlling Metabolism


Thursday, January 25 | 8:00AM - 11:00AM
Skeletal Muscle: Use and Disuse
This session is from Bioenergetics
Room: Quandary Peak
The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia.
Speaker 7 of 8
Kelsey H. Fisher-Wellman, Duke Molecular Physiology Institute, USA
Short Talk: Organic Cations as a Class Lower the Efficiency of Mitochondria Energy Transduction and Protect against Nutrient-Induced Metabolic Disease


Thursday, January 25 | 8:00AM - 11:00AM
Skeletal Muscle: Use and Disuse
This session is from Bioenergetics
Room: Quandary Peak
The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia.
Speaker 8 of 8
David J. Glass, Regeneron Pharmaceuticals, Inc., USA
Molecular Mechanisms Regulating Muscle Mass and Mitochondria


Thursday, January 25 | 11:00AM - 12:00PM
Lunch
Room: Colorado Rockies Ballroom


Thursday, January 25 | 12:00PM - 2:30PM
Poster Session 4
Room: Colorado Rockies Ballroom


Thursday, January 25 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity and Metabolism (Joint)
Room: Grays/Longs Peak

Speaker 1 of 9
* Alessandro Pocai, Janssen, Pharmaceutical Companies of Johnson & Johnson, USA

Thursday, January 25 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity and Metabolism (Joint)
Room: Grays/Longs Peak

Speaker 2 of 9
* Jacqueline M. Stephens, Louisiana State University, USA

Thursday, January 25 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity and Metabolism (Joint)
Room: Grays/Longs Peak

Speaker 3 of 9
Anna Worthmann, University Medical Center Hamburg-Eppendorf, Germany
Increased Hepatic Bile Acid Production Shapes the Gut Microbiome after Cold Induced Brown Adipose Tissue Activation

Thursday, January 25 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity and Metabolism (Joint)
Room: Grays/Longs Peak

Speaker 4 of 9
Raul C. Camacho, Janssen, USA
Amino Acids as Glucagon Receptor Specific Biomarkers for Glucagon Receptor/Glucagon-Like Peptide 1 Receptor Dual Agonists

Thursday, January 25 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity and Metabolism (Joint)
Room: Grays/Longs Peak

Speaker 5 of 9
Katrin J. Svensson, Stanford University, USA
Isthmin Is a Secreted Protein that Prevents Hepatic Steatosis and Regulates Glucose Homeostasis

Thursday, January 25 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity and Metabolism (Joint)
Room: Grays/Longs Peak

Speaker 6 of 9
Anthony Scime, York University, Canada
A Novel Energy Sensing Mechanism that Synchronizes Progenitor Cell Metabolism

Thursday, January 25 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity and Metabolism (Joint)
Room: Grays/Longs Peak

Speaker 7 of 9
Chelsea Hepler, University of Texas Southwestern Medical Center, USA
Directing Visceral White Adipocyte Precursors to a Thermogenic Adipocyte Fate

Thursday, January 25 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity and Metabolism (Joint)
Room: Grays/Longs Peak

Speaker 8 of 9
Alexander Bartelt, Ludwig-Maximilians-University, Germany
Brown Fat Thermogenic Adaptation Requires Nfe2l1-Induced Proteasomal Activity

Thursday, January 25 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity and Metabolism (Joint)
Room: Grays/Longs Peak

Speaker 9 of 9
Michael D. Neinast, University of Pennsylvania, USA
Whole-Body Metabolic Fate of Branched Chain Amino Acids in Health and Insulin Resistance

Thursday, January 25 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 25 | 5:00PM - 6:45PM
Fat on the Brain: Adipose-Brain Crosstalk
Room: Grays/Longs Peak

Speaker 1 of 4
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

Thursday, January 25 | 5:00PM - 6:45PM
Fat on the Brain: Adipose-Brain Crosstalk
Room: Grays/Longs Peak

Speaker 2 of 4
Gary J. Schwartz, Albert Einstein College of Medicine, USA
Metabolic Sensing in Adipose Tissue Nerves

Thursday, January 25 | 5:00PM - 6:45PM
Fat on the Brain: Adipose-Brain Crosstalk
Room: Grays/Longs Peak

Speaker 3 of 4
Pierre Léopold, Institut Curie, Paris, France
Humoral Communication between Fat and Brain in Drosophila

Thursday, January 25 | 5:00PM - 6:45PM
Fat on the Brain: Adipose-Brain Crosstalk
Room: Grays/Longs Peak

Speaker 4 of 4
Suneil K. Koliwad, University of California, San Francisco, USA
Hypothalamic Microglia as Fat Sensors: Physiology vs. Pathology

Thursday, January 25 | 5:00PM - 6:45PM
Novel Effectors of Energy Metabolism
This session is from Bioenergetics
Room: Quandary Peak
Discuss novel pathways/factors that regulate energy expenditure in adipose or skeletal muscle.
Speaker 1 of 5
* Claudio J. Villanueva, University of California, Los Angeles, USA


Thursday, January 25 | 5:00PM - 6:45PM
Novel Effectors of Energy Metabolism
This session is from Bioenergetics
Room: Quandary Peak
Discuss novel pathways/factors that regulate energy expenditure in adipose or skeletal muscle.
Speaker 2 of 5
* Sheila Collins, Vanderbilt University Medical Center, USA


Thursday, January 25 | 5:00PM - 6:45PM
Novel Effectors of Energy Metabolism
This session is from Bioenergetics
Room: Quandary Peak
Discuss novel pathways/factors that regulate energy expenditure in adipose or skeletal muscle.
Speaker 3 of 5
Shingo Kajimura, University of California, San Francisco, USA
BAT-Secreted Adipokines Regulate Energy Expenditure


Thursday, January 25 | 5:00PM - 6:45PM
Novel Effectors of Energy Metabolism
This session is from Bioenergetics
Room: Quandary Peak
Discuss novel pathways/factors that regulate energy expenditure in adipose or skeletal muscle.
Speaker 4 of 5
Jiandie Lin, University of Michigan Medical School, USA
Endocrine Checkpoint for NASH Progression


Thursday, January 25 | 5:00PM - 6:45PM
Novel Effectors of Energy Metabolism
This session is from Bioenergetics
Room: Quandary Peak
Discuss novel pathways/factors that regulate energy expenditure in adipose or skeletal muscle.
Speaker 5 of 5
Ajay Chawla, Merck and University of California, San Francisco, USA
Host Immunity and Energetics


Thursday, January 25 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Grays/Longs Peak


Thursday, January 25 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Bioenergetics
Room: Quandary Peak


Thursday, January 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, January 25 | 8:00PM - 11:00PM
Entertainment
Room: Colorado Rockies Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 25 | 8:00PM - 11:00PM
Cash Bar
Room: Colorado Rockies Ballroom


Friday, January 26 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.