Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
There are no records.

Web Desc
Bioenergetics and Metabolic Disease joint with Organ Crosstalk in Obesity and NAFLD Organizer(s): Patrick Seale, Kendra K. Bence and P. Darrell Neufer Date: January 21 - 25, 2018 Location: Keystone Resort, Keystone, CO, USA Sponsored by MedImmune, Moderna Therapeutics and Novo Nordisk A/S Summary of Meeting: Obesity and type 2 diabetes are major drivers of chronic disease and premature death. A promising strategy to reduce obesity and improve metabolic health is through promoting energy expenditure via thermogenesis, including obligatory (accompanies all metabolic processes) and facultative (adaptive) mechanisms. Obesity and insulin resistance also lead to profound metabolic changes in various cells/tissues that contribute to tissue dysfunction. This conference brings together basic and clinical researchers from industry and academia focused on the study of cellular and organismal energy metabolism in the context of metabolic disease. A variety of approaches and topics will be featured, including: basic mechanisms of mitochondrial and cellular energetics; the emerging role of brown and beige fat in adaptive thermogenesis; central regulation of energy expenditure; and the effects of exercise on muscle and whole-body metabolism. In addition to the plenary sessions, the meeting will feature workshops on emerging research areas and novel therapeutic opportunities. Overall, the goals of the conference are to: 1) Provide a cutting-edge understanding of the basic mechanisms that control cellular and whole-body energetics; 2) Discuss the physiological role of brown fat and other energy expenditure pathways in humans; 3) Consider novel strategies for increasing energy expenditure and combating metabolic disease; and 4) Engage attendees in critical discussions about important areas for future research. Scholarship Deadline: September 28 2017 Discounted Abstract Deadline: September 28 2017 Abstract Deadline: October 26 2017 Discounted Registration Deadline: November 29 2017 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Grant No. 1 R13 DK116303-01 Funding for this conference was made possible (in part) by 1 R13 DK116303-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Bioenergetics and Metabolic Disease

joint with Organ Crosstalk in Obesity and NAFLD

Organizer(s): Patrick Seale, Kendra K. Bence and P. Darrell Neufer

Date: January 21 - 25, 2018
Location: Keystone Resort, Keystone, CO, USA

Sponsored by MedImmune, Moderna Therapeutics and Novo Nordisk A/S

Summary of Meeting:

Obesity and type 2 diabetes are major drivers of chronic disease and premature death. A promising strategy to reduce obesity and improve metabolic health is through promoting energy expenditure via thermogenesis, including obligatory (accompanies all metabolic processes) and facultative (adaptive) mechanisms. Obesity and insulin resistance also lead to profound metabolic changes in various cells/tissues that contribute to tissue dysfunction. This conference brings together basic and clinical researchers from industry and academia focused on the study of cellular and organismal energy metabolism in the context of metabolic disease. A variety of approaches and topics will be featured, including: basic mechanisms of mitochondrial and cellular energetics; the emerging role of brown and beige fat in adaptive thermogenesis; central regulation of energy expenditure; and the effects of exercise on muscle and whole-body metabolism. In addition to the plenary sessions, the meeting will feature workshops on emerging research areas and novel therapeutic opportunities. Overall, the goals of the conference are to: 1) Provide a cutting-edge understanding of the basic mechanisms that control cellular and whole-body energetics; 2) Discuss the physiological role of brown fat and other energy expenditure pathways in humans; 3) Consider novel strategies for increasing energy expenditure and combating metabolic disease; and 4) Engage attendees in critical discussions about important areas for future research.

Scholarship Deadline: September 28 2017

Discounted Abstract Deadline: September 28 2017

Abstract Deadline: October 26 2017

Discounted Registration Deadline: November 29 2017

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1 R13 DK116303-01
Funding for this conference was made possible (in part) by 1 R13 DK116303-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, January 21 \| 4:00PM - 8:00PM Arrival and Registration Room: Longs Peak Foyer
Sunday, January 21 \| 6:00PM - 8:00PM Welcome Mixer Room: Longs Peak Foyer No registration fees are used to fund alcohol served at this function.
Monday, January 22 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Monday, January 22 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Columbine Ballroom This lecture will provide a broad introduction to the central control of various metabolic parameters. Speaker 1 of 3 * Gary J. Schwartz, Albert Einstein College of Medicine, USA
Monday, January 22 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Columbine Ballroom This lecture will provide a broad introduction to the central control of various metabolic parameters. Speaker 2 of 3 * Patrick Seale, University of Pennsylvania, USA
Monday, January 22 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Columbine Ballroom This lecture will provide a broad introduction to the central control of various metabolic parameters. Speaker 3 of 3 Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany Control of Integrative Physiology by the Melanocortin Circuitry
Monday, January 22 \| 9:00AM - 11:30AM Central Modulation of Metabolism (Joint) Room: Columbine Ballroom Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Speaker 1 of 8 * Gary J. Schwartz, Albert Einstein College of Medicine, USA
Monday, January 22 \| 9:00AM - 11:30AM Central Modulation of Metabolism (Joint) Room: Columbine Ballroom Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Speaker 2 of 8 * Gregory James Morton, University of Washington, USA
Monday, January 22 \| 9:00AM - 11:30AM Central Modulation of Metabolism (Joint) Room: Columbine Ballroom Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Speaker 3 of 8 Matthew R. Hayes, University of Pennsylvania, USA Metabolic Neuropeptides as Modulators of Energy Balance, Motivation and Reward
Monday, January 22 \| 9:00AM - 11:30AM Central Modulation of Metabolism (Joint) Room: Columbine Ballroom Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Coffee Break
Monday, January 22 \| 9:00AM - 11:30AM Central Modulation of Metabolism (Joint) Room: Columbine Ballroom Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Speaker 5 of 8 Xiaoyong Yang, Yale University School of Medicine, USA Short Talk: O-GlcNAc Signaling in Central Nutrient Sensing and Brain-Fat-Liver Communication
Monday, January 22 \| 9:00AM - 11:30AM Central Modulation of Metabolism (Joint) Room: Columbine Ballroom Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Speaker 6 of 8 Christoph Buettner, Mount Sinai School of Medicine, USA Brain Control of Adipose Tissue Functionality as a Determinant of Hypothalamic and Liver Function
Monday, January 22 \| 9:00AM - 11:30AM Central Modulation of Metabolism (Joint) Room: Columbine Ballroom Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Speaker 7 of 8 Daniel L. Marks, Oregon Health & Science University, USA Central Mechanisms in Cancer Cachexia
Monday, January 22 \| 9:00AM - 11:30AM Central Modulation of Metabolism (Joint) Room: Columbine Ballroom Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Speaker 8 of 8 Bernard B. Allan, NGM Biopharmaceuticals, USA Short Talk: GDF15 Induces Cancer Anorexia and Cachexia through GFRAL-dependent Activation of Neuronal Circuitry
Monday, January 22 \| 11:15AM - 5:00PM On Own for Lunch
Monday, January 22 \| 11:15AM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Monday, January 22 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Monday, January 22 \| 2:30PM - 4:30PM Workshop 1: Emerging Therapeutic Targets for Metabolic Disea se (Joint) Room: Columbine Ballroom Speaker 1 of 9 * Cecile Vernochet, Bill & Melinda Gates Medical Research Institute, USA
Monday, January 22 \| 2:30PM - 4:30PM Workshop 1: Emerging Therapeutic Targets for Metabolic Disea se (Joint) Room: Columbine Ballroom Speaker 2 of 9 * Shamina M. Rangwala, Pfizer, USA
Monday, January 22 \| 2:30PM - 4:30PM Workshop 1: Emerging Therapeutic Targets for Metabolic Disea se (Joint) Room: Columbine Ballroom Speaker 3 of 9 Philipa Levesque-Damphousse, Institut de Recherches Cliniques de Montréal, Canada SerpinA3N, an Early Biomarker of Non-Alcoholic Fatty Liver Disease
Monday, January 22 \| 2:30PM - 4:30PM Workshop 1: Emerging Therapeutic Targets for Metabolic Disea se (Joint) Room: Columbine Ballroom Speaker 4 of 9 Majid Mufaqam Syed-Abdul, University of Missouri, USA Progressive Reductions in Hepatic DNL with Increasing Doses of TVB-2640, a First-in-Class Pharmacologic Inhibitor of FASN
Monday, January 22 \| 2:30PM - 4:30PM Workshop 1: Emerging Therapeutic Targets for Metabolic Disea se (Joint) Room: Columbine Ballroom Speaker 5 of 9 Senad Divanovic, Cincinnati Children's Hospital Medical Center, USA Metabolic Reprogramming of Th17 Cells Regulates Inflammatory Vigor and NAFLD Pathogenesis
Monday, January 22 \| 2:30PM - 4:30PM Workshop 1: Emerging Therapeutic Targets for Metabolic Disea se (Joint) Room: Columbine Ballroom Speaker 6 of 9 Joe S. Grimsby, AstraZeneca, USA GLP-1R/GCGR Dual Agonist Reduced Obesity by Increasing Energy Expenditure due to its Effects in Brown Adipose Tissue and Browning of White Fat
Monday, January 22 \| 2:30PM - 4:30PM Workshop 1: Emerging Therapeutic Targets for Metabolic Disea se (Joint) Room: Columbine Ballroom Speaker 7 of 9 Hyeonwoo Kim, Dana-Farber Cancer Institute/Harvard Medical School, USA Identification of the Irisin Receptor and its Role in Exercise
Monday, January 22 \| 2:30PM - 4:30PM Workshop 1: Emerging Therapeutic Targets for Metabolic Disea se (Joint) Room: Columbine Ballroom Speaker 8 of 9 Brian N. Finck, Washington University School of Medicine, USA Identification of Mitochondrial Pyruvate Carrier Modulators to Treat Diabetes and NAFLD
Monday, January 22 \| 2:30PM - 4:30PM Workshop 1: Emerging Therapeutic Targets for Metabolic Disea se (Joint) Room: Columbine Ballroom Speaker 9 of 9 Monica Dentice, Università degli Studi di Napoli Federico II, Italy Muscle-Specific Action of Deiodinases Induces Metabolic Switches in Muscle thereby Influencing Systemic Energy Metabolism
Monday, January 22 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, January 22 \| 5:00PM - 7:00PM Brown and Beige Fat Thermogenesis Room: Quandary Peak Discuss mechanisms that control the development and thermogenic function of brown and beige fat. Speaker 1 of 6 * Jan Nedergaard, Stockholm University, Sweden
Monday, January 22 \| 5:00PM - 7:00PM Brown and Beige Fat Thermogenesis Room: Quandary Peak Discuss mechanisms that control the development and thermogenic function of brown and beige fat. Speaker 2 of 6 * Kristy L. Townsend, University of Maine, USA
Monday, January 22 \| 5:00PM - 7:00PM Brown and Beige Fat Thermogenesis Room: Quandary Peak Discuss mechanisms that control the development and thermogenic function of brown and beige fat. Speaker 3 of 6 Patrick Seale, University of Pennsylvania, USA Molecular Regulation of Brown and Beige Adipogenesis
Monday, January 22 \| 5:00PM - 7:00PM Brown and Beige Fat Thermogenesis Room: Quandary Peak Discuss mechanisms that control the development and thermogenic function of brown and beige fat. Speaker 4 of 6 Sheila Collins, Vanderbilt University Medical Center, USA Receptor Systems and Signaling Mechanisms in White and Brown Adipocytes
Monday, January 22 \| 5:00PM - 7:00PM Brown and Beige Fat Thermogenesis Room: Quandary Peak Discuss mechanisms that control the development and thermogenic function of brown and beige fat. Speaker 5 of 6 Evan D. Rosen, Harvard University, USA Epigenomic Characterization of Beige Adipocyte Plasticity
Monday, January 22 \| 5:00PM - 7:00PM Brown and Beige Fat Thermogenesis Room: Quandary Peak Discuss mechanisms that control the development and thermogenic function of brown and beige fat. Speaker 6 of 6 Zach Gerhart-Hines, University of Copenhagen, Denmark Short Talk: Cardiolipin Synthesis Governs Systemic Energy Homeostasis through Thermogenic Fat Mitochondria
Monday, January 22 \| 5:00PM - 7:00PM Sweet Spots in the Brain: Central Glucose Sensing and Periph eral Glucose Homeostasis This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 1 of 6 * Christoph Buettner, Mount Sinai School of Medicine, USA
Monday, January 22 \| 5:00PM - 7:00PM Sweet Spots in the Brain: Central Glucose Sensing and Periph eral Glucose Homeostasis This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 2 of 6 * Zachary A. Knight, University of California, San Francisco, USA
Monday, January 22 \| 5:00PM - 7:00PM Sweet Spots in the Brain: Central Glucose Sensing and Periph eral Glucose Homeostasis This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 3 of 6 Sarah Stanley, Icahn School of Medicine at Mount Sinai, USA New Tools to Study the Role of Glucose-Sensing Neurons
Monday, January 22 \| 5:00PM - 7:00PM Sweet Spots in the Brain: Central Glucose Sensing and Periph eral Glucose Homeostasis This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 4 of 6 Gregory James Morton, University of Washington, USA CNS Mechanisms Governing Diabetic Hyperglycemia
Monday, January 22 \| 5:00PM - 7:00PM Sweet Spots in the Brain: Central Glucose Sensing and Periph eral Glucose Homeostasis This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 5 of 6 Greg S. B. Suh, New York University School of Medicine, USA Feeding and Nutrient Sensing in Flies and Mice
Monday, January 22 \| 5:00PM - 7:00PM Sweet Spots in the Brain: Central Glucose Sensing and Periph eral Glucose Homeostasis This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 6 of 6 Eleni Rebelos, Turku University, Finland Short Talk: Brain-Liver-Pancreas Axis Revised with FDG-PET Imaging
Monday, January 22 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Monday, January 22 \| 7:30PM - 10:00PM Poster Session 1 Room: Colorado Rockies Ballroom
Tuesday, January 23 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Tuesday, January 23 \| 8:00AM - 9:00AM Keynote Address (Joint) Room: Columbine Ballroom Speaker 1 of 2 * Patrick Seale, University of Pennsylvania, USA
Tuesday, January 23 \| 8:00AM - 9:00AM Keynote Address (Joint) Room: Columbine Ballroom Speaker 2 of 2 Bruce M. Spiegelman, Harvard Medical School, USA Pathways that Control Cellular and Organismal Energy Metabolism
Tuesday, January 23 \| 9:00AM - 11:30AM Adipose Plasticity and Metabolism (Joint) Room: Columbine Ballroom Evaluate how adipose tissue function and dysfunction influences systemic metabolism. Speaker 1 of 8 * Barbara Cannon, Stockholm University, Sweden
Tuesday, January 23 \| 9:00AM - 11:30AM Adipose Plasticity and Metabolism (Joint) Room: Columbine Ballroom Evaluate how adipose tissue function and dysfunction influences systemic metabolism. Speaker 2 of 8 * Li Qiang, Columbia University Medical Center, USA
Tuesday, January 23 \| 9:00AM - 11:30AM Adipose Plasticity and Metabolism (Joint) Room: Columbine Ballroom Evaluate how adipose tissue function and dysfunction influences systemic metabolism. Speaker 3 of 8 Susan K. Fried, Icahn School of Medicine at Mount Sinai, USA Sex- and Depot- Dependent Mechanisms Shaping Fat Distribution and Metabolic Health
Tuesday, January 23 \| 9:00AM - 11:30AM Adipose Plasticity and Metabolism (Joint) Room: Columbine Ballroom Evaluate how adipose tissue function and dysfunction influences systemic metabolism. Coffee Break
Tuesday, January 23 \| 9:00AM - 11:30AM Adipose Plasticity and Metabolism (Joint) Room: Columbine Ballroom Evaluate how adipose tissue function and dysfunction influences systemic metabolism. Speaker 5 of 8 Philipp E. Scherer, University of Texas Southwestern Medical Center, USA Adipose Fibrosis in Metabolic Regulation
Tuesday, January 23 \| 9:00AM - 11:30AM Adipose Plasticity and Metabolism (Joint) Room: Columbine Ballroom Evaluate how adipose tissue function and dysfunction influences systemic metabolism. Speaker 6 of 8 Su Myung Jung, University of Massachusetts Medical School, USA Short Talk: A Non-Canonical mTORC2 Signaling Pathway that Regulates Thermogenesis
Tuesday, January 23 \| 9:00AM - 11:30AM Adipose Plasticity and Metabolism (Joint) Room: Columbine Ballroom Evaluate how adipose tissue function and dysfunction influences systemic metabolism. Speaker 7 of 8 Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA Control of Systemic Metabolism by de novo Lipogenesis in Adipose
Tuesday, January 23 \| 9:00AM - 11:30AM Adipose Plasticity and Metabolism (Joint) Room: Columbine Ballroom Evaluate how adipose tissue function and dysfunction influences systemic metabolism. Speaker 8 of 8 Paul Cohen, Rockefeller University, USA Short Talk: Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density
Tuesday, January 23 \| 11:00AM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Tuesday, January 23 \| 11:30AM - 5:00PM On Own for Lunch
Tuesday, January 23 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Tuesday, January 23 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, January 23 \| 5:00PM - 7:00PM Mitochondria: Form and Function Room: Quandary Peak Discuss key concepts and mechanisms involved in controlling mitochondrial dynamics and energetics. Speaker 1 of 6 * P. Darrell Neufer, East Carolina University, USA
Tuesday, January 23 \| 5:00PM - 7:00PM Mitochondria: Form and Function Room: Quandary Peak Discuss key concepts and mechanisms involved in controlling mitochondrial dynamics and energetics. Speaker 2 of 6 * Zhidan Wu, Pfizer, USA
Tuesday, January 23 \| 5:00PM - 7:00PM Mitochondria: Form and Function Room: Quandary Peak Discuss key concepts and mechanisms involved in controlling mitochondrial dynamics and energetics. Speaker 3 of 6 Jodi Nunnari, University of California, Davis, USA Mitochondrial Behavior
Tuesday, January 23 \| 5:00PM - 7:00PM Mitochondria: Form and Function Room: Quandary Peak Discuss key concepts and mechanisms involved in controlling mitochondrial dynamics and energetics. Speaker 4 of 6 Mary-Ellen Harper, University of Ottawa, Canada Acute Control of the Uncoupling Proteins: Redox, ROS Feedback Loops and Post-Translational Modifications
Tuesday, January 23 \| 5:00PM - 7:00PM Mitochondria: Form and Function Room: Quandary Peak Discuss key concepts and mechanisms involved in controlling mitochondrial dynamics and energetics. Speaker 5 of 6 Erin Leah Seifert, Thomas Jefferson University, USA Short Talk: Loss of Mitochondrial Phosphate Carrier in Skeletal Muscle: Dissociation of Muscle Dysfunction from Lower ADP Phosphorylating Potential
Tuesday, January 23 \| 5:00PM - 7:00PM Mitochondria: Form and Function Room: Quandary Peak Discuss key concepts and mechanisms involved in controlling mitochondrial dynamics and energetics. Speaker 6 of 6 Daniel P. Kelly, University of Pennsylvania, USA Transcriptional Control of Mitochondrial Fuel Metabolism
Tuesday, January 23 \| 5:00PM - 7:00PM Hepatic Metabolism in Obesity This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 1 of 6 * Bei B. Zhang, Pfizer Inc., USA
Tuesday, January 23 \| 5:00PM - 7:00PM Hepatic Metabolism in Obesity This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 2 of 6 * Rebecca A. Haeusler, Columbia University, USA
Tuesday, January 23 \| 5:00PM - 7:00PM Hepatic Metabolism in Obesity This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 3 of 6 Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA Compartmentalization of Hepatic Lipid Metabolism
Tuesday, January 23 \| 5:00PM - 7:00PM Hepatic Metabolism in Obesity This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 4 of 6 Morris J. Birnbaum, Pfizer Inc., USA Regulation of Hepatic Lipid Accumulation
Tuesday, January 23 \| 5:00PM - 7:00PM Hepatic Metabolism in Obesity This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 5 of 6 Baoliang Song, Wuhan University, China New Explorations on the Ancient Cholesterol Molecule
Tuesday, January 23 \| 5:00PM - 7:00PM Hepatic Metabolism in Obesity This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 6 of 6 Chaofeng Yang, University of Texas Southwestern Medical Center, USA Short Talk: Plin5 Is a Key Regulator of Lipid and Glucose Metabolism in the Liver
Tuesday, January 23 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Tuesday, January 23 \| 7:30PM - 10:00PM Poster Session 2 Room: Colorado Rockies Ballroom
Wednesday, January 24 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Wednesday, January 24 \| 8:00AM - 11:00AM Energy Expenditure and Body Weight Regulation in Humans Room: Quandary Peak Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency. Speaker 1 of 8 * Alexander S. Banks, Harvard Medical School, USA
Wednesday, January 24 \| 8:00AM - 11:00AM Energy Expenditure and Body Weight Regulation in Humans Room: Quandary Peak Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency. Speaker 2 of 8 * Anna Krook, Karolinska Institutet, Sweden
Wednesday, January 24 \| 8:00AM - 11:00AM Energy Expenditure and Body Weight Regulation in Humans Room: Quandary Peak Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency. Speaker 3 of 8 Herman Pontzer, Hunter College, USA Evolutionary Origins of Obesity
Wednesday, January 24 \| 8:00AM - 11:00AM Energy Expenditure and Body Weight Regulation in Humans Room: Quandary Peak Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency. Speaker 4 of 8 Michael Rosenbaum, Columbia University Medical College, USA Regulation of Energy Balance following Weight Reduction
Wednesday, January 24 \| 8:00AM - 11:00AM Energy Expenditure and Body Weight Regulation in Humans Room: Quandary Peak Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency. Coffee Break
Wednesday, January 24 \| 8:00AM - 11:00AM Energy Expenditure and Body Weight Regulation in Humans Room: Quandary Peak Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency. Speaker 6 of 8 Wouter D. van Marken Lichtenbelt, Maastricht University, Netherlands Cold Exposure and Metabolic Health: Role Brown Adipose Tissue and Skeletal Muscle
Wednesday, January 24 \| 8:00AM - 11:00AM Energy Expenditure and Body Weight Regulation in Humans Room: Quandary Peak Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency. Speaker 7 of 8 Denis P. Blondin, University of Sherbrooke, Canada Short Talk: White Adipose Tissue Lipolysis Not Just a Fuel Supply: Re-Visiting the Significant Thermogenic Contribution of the Triglyceride-Fatty Acid Cycle in Humans Exposed to the Cold or Stimulated with a ß3-Adrenergic Receptor Agonist (Mirabegron
Wednesday, January 24 \| 8:00AM - 11:00AM Energy Expenditure and Body Weight Regulation in Humans Room: Quandary Peak Discussion centered on energy expenditure in humans and non-human primates. Topics include importance of brown fat thermogenesis in people and the effect of weight reduction on muscle efficiency. Speaker 8 of 8 Steven R. Smith, AdventHealth, USA Metabolic Flexibility and Energy Utilization
Wednesday, January 24 \| 8:00AM - 11:00AM Hepatic Dysfunction in NASH and NAFLD This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 1 of 8 * Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Wednesday, January 24 \| 8:00AM - 11:00AM Hepatic Dysfunction in NASH and NAFLD This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 2 of 8 * Utpal B. Pajvani, Columbia University Medical Center, USA
Wednesday, January 24 \| 8:00AM - 11:00AM Hepatic Dysfunction in NASH and NAFLD This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 3 of 8 Gyongyi Szabo, University of Massachusetts Medical School, USA Inflammasome Activation Pathways in NAFLD and NASH
Wednesday, January 24 \| 8:00AM - 11:00AM Hepatic Dysfunction in NASH and NAFLD This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 4 of 8 Samuel Klein, Washington University School of Medicine, USA Biochemical, Metabolic and Clinical Implications in Obesity and NASH
Wednesday, January 24 \| 8:00AM - 11:00AM Hepatic Dysfunction in NASH and NAFLD This session is from Obesity and NAFLD Room: Grays/Longs Peak Coffee Break
Wednesday, January 24 \| 8:00AM - 11:00AM Hepatic Dysfunction in NASH and NAFLD This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 6 of 8 Gerald I. Shulman, Yale University School of Medicine, USA Targeting Mitochondria to Treat NAFLD, NASH and Type 2 Diabetes
Wednesday, January 24 \| 8:00AM - 11:00AM Hepatic Dysfunction in NASH and NAFLD This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 7 of 8 Elizabeth J. Parks, University of Missouri, USA Drug Development in NAFLD: From Lipogenesis to Fibrosis
Wednesday, January 24 \| 8:00AM - 11:00AM Hepatic Dysfunction in NASH and NAFLD This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 8 of 8 Anna Laitakari, University of Oulu, Finland Short Talk: Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects against Fatty Liver Disease and Metabolic Dysfunction in Mice
Wednesday, January 24 \| 11:00AM - 5:00PM On Own for Lunch
Wednesday, January 24 \| 11:00AM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Wednesday, January 24 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Wednesday, January 24 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, January 24 \| 5:00PM - 7:00PM Cellular Regulators of Bioenergetics Room: Quandary Peak Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Speaker 1 of 6 * Deborah M. Muoio, Duke University Medical Center, USA
Wednesday, January 24 \| 5:00PM - 7:00PM Cellular Regulators of Bioenergetics Room: Quandary Peak Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Speaker 2 of 6 * Jorge L. Ruas, Karolinska Institutet, Sweden
Wednesday, January 24 \| 5:00PM - 7:00PM Cellular Regulators of Bioenergetics Room: Quandary Peak Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Speaker 3 of 6 P. Darrell Neufer, East Carolina University, USA Redox Circuit Flux and Energy Expenditure
Wednesday, January 24 \| 5:00PM - 7:00PM Cellular Regulators of Bioenergetics Room: Quandary Peak Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Speaker 4 of 6 Muthu Periasamy, University of Central Florida, USA Skeletal Muscle-Based Thermogenic Mechanisms
Wednesday, January 24 \| 5:00PM - 7:00PM Cellular Regulators of Bioenergetics Room: Quandary Peak Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Speaker 5 of 6 Edward T. Chouchani, Dana-Farber Cancer Institute, USA Short Talk: A Novel Molecular Pathway Controls Acute Activation of Adipose Tissue Thermogenesis
Wednesday, January 24 \| 5:00PM - 7:00PM Cellular Regulators of Bioenergetics Room: Quandary Peak Discuss the neural circuits and signaling pathways that regulate energy expenditure and energy homeostasis. Speaker 6 of 6 Daniel Garcia, The Salk Institute for Biological Studies, USA AMPK Control of Cellular Energetics
Wednesday, January 24 \| 5:00PM - 7:00PM The Many Scars of Obesity: Systemic Fibrosis and Hypothalami c Gliosis This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 1 of 6 * Kendra K. Bence, Pfizer Inc., USA
Wednesday, January 24 \| 5:00PM - 7:00PM The Many Scars of Obesity: Systemic Fibrosis and Hypothalami c Gliosis This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 2 of 6 * Suneil K. Koliwad, University of California, San Francisco, USA
Wednesday, January 24 \| 5:00PM - 7:00PM The Many Scars of Obesity: Systemic Fibrosis and Hypothalami c Gliosis This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 3 of 6 Bart Staels, Institut Pasteur de Lille, Université Lille, France Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease
Wednesday, January 24 \| 5:00PM - 7:00PM The Many Scars of Obesity: Systemic Fibrosis and Hypothalami c Gliosis This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 4 of 6 Joshua Thaler, University of Washington, USA Hypothalamic Gliosis
Wednesday, January 24 \| 5:00PM - 7:00PM The Many Scars of Obesity: Systemic Fibrosis and Hypothalami c Gliosis This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 5 of 6 Ana Domingos, University of Oxford, UK Sympathetic Neuroimmunity for Obesity
Wednesday, January 24 \| 5:00PM - 7:00PM The Many Scars of Obesity: Systemic Fibrosis and Hypothalami c Gliosis This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 6 of 6 Utpal B. Pajvani, Columbia University Medical Center, USA Short Talk: Notch Mediates Hepatocyte-HSC Crosstalk to Induce Fibrosis in NASH
Wednesday, January 24 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Wednesday, January 24 \| 7:30PM - 10:00PM Poster Session 3 Room: Colorado Rockies Ballroom
Thursday, January 25 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Thursday, January 25 \| 7:30AM - 8:00AM Poster Setup Room: Colorado Rockies Ballroom
Thursday, January 25 \| 8:00AM - 5:00PM Poster Viewing Room: Colorado Rockies Ballroom
Thursday, January 25 \| 8:00AM - 11:00AM Skeletal Muscle: Use and Disuse Room: Quandary Peak The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia. Speaker 1 of 8 * Bruce M. Spiegelman, Harvard Medical School, USA
Thursday, January 25 \| 8:00AM - 11:00AM Skeletal Muscle: Use and Disuse Room: Quandary Peak The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia. Speaker 2 of 8 * Erin Leah Seifert, Thomas Jefferson University, USA
Thursday, January 25 \| 8:00AM - 11:00AM Skeletal Muscle: Use and Disuse Room: Quandary Peak The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia. Speaker 3 of 8 Juleen R. Zierath, Karolinska Institutet, Sweden Epigenetic Control and the Circadian Clock: Turning Back Time on Diabetes Pathogenesis
Thursday, January 25 \| 8:00AM - 11:00AM Skeletal Muscle: Use and Disuse Room: Quandary Peak The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia. Speaker 4 of 8 David E. James, University of Sydney, Australia Probing the Exercise Regulated Phosphoproteome in Skeletal Muscle
Thursday, January 25 \| 8:00AM - 11:00AM Skeletal Muscle: Use and Disuse Room: Quandary Peak The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia. Coffee Break
Thursday, January 25 \| 8:00AM - 11:00AM Skeletal Muscle: Use and Disuse Room: Quandary Peak The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia. Speaker 6 of 8 Deborah M. Muoio, Duke University Medical Center, USA Adaptive Responses to Exercise Controlling Metabolism
Thursday, January 25 \| 8:00AM - 11:00AM Skeletal Muscle: Use and Disuse Room: Quandary Peak The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia. Speaker 7 of 8 Kelsey H. Fisher-Wellman, Duke Molecular Physiology Institute, USA Short Talk: Organic Cations as a Class Lower the Efficiency of Mitochondria Energy Transduction and Protect against Nutrient-Induced Metabolic Disease
Thursday, January 25 \| 8:00AM - 11:00AM Skeletal Muscle: Use and Disuse Room: Quandary Peak The following topics will be covered: (1) Effects of physical activity on muscle and whole-body metabolism; (2) Mechanisms and impact of muscle cachexia. Speaker 8 of 8 David J. Glass, Regeneron Pharmaceuticals, Inc., USA Molecular Mechanisms Regulating Muscle Mass and Mitochondria
Thursday, January 25 \| 8:00AM - 11:00AM Feel Your Gut: The Gut-Brain-Food Connection This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 1 of 8 * Elizabeth J. Parks, University of Missouri, USA
Thursday, January 25 \| 8:00AM - 11:00AM Feel Your Gut: The Gut-Brain-Food Connection This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 2 of 8 * Thomas Alexander Lutz, University of Zürich, Switzerland
Thursday, January 25 \| 8:00AM - 11:00AM Feel Your Gut: The Gut-Brain-Food Connection This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 3 of 8 Zachary A. Knight, University of California, San Francisco, USA Nutritional Regulation of Hunger Circuits
Thursday, January 25 \| 8:00AM - 11:00AM Feel Your Gut: The Gut-Brain-Food Connection This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 4 of 8 Kendra K. Bence, Pfizer Inc., USA Targeting Fructose Metabolism for the Treatment of NAFLD/NASH
Thursday, January 25 \| 8:00AM - 11:00AM Feel Your Gut: The Gut-Brain-Food Connection This session is from Obesity and NAFLD Room: Grays/Longs Peak Coffee Break
Thursday, January 25 \| 8:00AM - 11:00AM Feel Your Gut: The Gut-Brain-Food Connection This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 6 of 8 Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute, Canada Gut Peptides Drive Metabolic Organs: Direct vs. Indirect Mechanisms
Thursday, January 25 \| 8:00AM - 11:00AM Feel Your Gut: The Gut-Brain-Food Connection This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 7 of 8 Mark D. Erion, Janssen Pharmaceuticals, USA Approaches Targeting Metabolic Control and Weight Management – From Mice to Man
Thursday, January 25 \| 8:00AM - 11:00AM Feel Your Gut: The Gut-Brain-Food Connection This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 8 of 8 Nicholas Vincent DiPatrizio, University of California, Riverside, School of Medicine, USA Short Talk: Endocannabinoids Inhibit Gut-Brain Satiation Signaling in Obesity
Thursday, January 25 \| 11:00AM - 12:00PM Lunch Room: Colorado Rockies Ballroom
Thursday, January 25 \| 12:00PM - 2:30PM Poster Session 4 Room: Colorado Rockies Ballroom
Thursday, January 25 \| 2:30PM - 4:30PM Workshop 2: Hot Topics in Obesity and Metabolism (Joint) Room: Grays/Longs Peak Speaker 1 of 9 * Alessandro Pocai, Janssen, Pharmaceutical Companies of Johnson & Johnson, USA
Thursday, January 25 \| 2:30PM - 4:30PM Workshop 2: Hot Topics in Obesity and Metabolism (Joint) Room: Grays/Longs Peak Speaker 2 of 9 * Jacqueline M. Stephens, Louisiana State University, USA
Thursday, January 25 \| 2:30PM - 4:30PM Workshop 2: Hot Topics in Obesity and Metabolism (Joint) Room: Grays/Longs Peak Speaker 3 of 9 Anna Worthmann, University Medical Center Hamburg-Eppendorf, Germany Increased Hepatic Bile Acid Production Shapes the Gut Microbiome after Cold Induced Brown Adipose Tissue Activation
Thursday, January 25 \| 2:30PM - 4:30PM Workshop 2: Hot Topics in Obesity and Metabolism (Joint) Room: Grays/Longs Peak Speaker 4 of 9 Raul C. Camacho, Janssen, USA Amino Acids as Glucagon Receptor Specific Biomarkers for Glucagon Receptor/Glucagon-Like Peptide 1 Receptor Dual Agonists
Thursday, January 25 \| 2:30PM - 4:30PM Workshop 2: Hot Topics in Obesity and Metabolism (Joint) Room: Grays/Longs Peak Speaker 5 of 9 Katrin J. Svensson, Stanford University, USA Isthmin Is a Secreted Protein that Prevents Hepatic Steatosis and Regulates Glucose Homeostasis
Thursday, January 25 \| 2:30PM - 4:30PM Workshop 2: Hot Topics in Obesity and Metabolism (Joint) Room: Grays/Longs Peak Speaker 6 of 9 Anthony Scime, York University, Canada A Novel Energy Sensing Mechanism that Synchronizes Progenitor Cell Metabolism
Thursday, January 25 \| 2:30PM - 4:30PM Workshop 2: Hot Topics in Obesity and Metabolism (Joint) Room: Grays/Longs Peak Speaker 7 of 9 Chelsea Hepler, University of Texas Southwestern Medical Center, USA Directing Visceral White Adipocyte Precursors to a Thermogenic Adipocyte Fate
Thursday, January 25 \| 2:30PM - 4:30PM Workshop 2: Hot Topics in Obesity and Metabolism (Joint) Room: Grays/Longs Peak Speaker 8 of 9 Alexander Bartelt, Ludwig-Maximilians-University, Germany Brown Fat Thermogenic Adaptation Requires Nfe2l1-Induced Proteasomal Activity
Thursday, January 25 \| 2:30PM - 4:30PM Workshop 2: Hot Topics in Obesity and Metabolism (Joint) Room: Grays/Longs Peak Speaker 9 of 9 Michael D. Neinast, University of Pennsylvania, USA Whole-Body Metabolic Fate of Branched Chain Amino Acids in Health and Insulin Resistance
Thursday, January 25 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, January 25 \| 5:00PM - 6:45PM Novel Effectors of Energy Metabolism Room: Quandary Peak Discuss novel pathways/factors that regulate energy expenditure in adipose or skeletal muscle. Speaker 1 of 5 * Claudio J. Villanueva, University of California, Los Angeles, USA
Thursday, January 25 \| 5:00PM - 6:45PM Novel Effectors of Energy Metabolism Room: Quandary Peak Discuss novel pathways/factors that regulate energy expenditure in adipose or skeletal muscle. Speaker 2 of 5 * Sheila Collins, Vanderbilt University Medical Center, USA
Thursday, January 25 \| 5:00PM - 6:45PM Novel Effectors of Energy Metabolism Room: Quandary Peak Discuss novel pathways/factors that regulate energy expenditure in adipose or skeletal muscle. Speaker 3 of 5 Shingo Kajimura, Harvard Medical School, Beth Israel Deaconess Medical Center, USA BAT-Secreted Adipokines Regulate Energy Expenditure
Thursday, January 25 \| 5:00PM - 6:45PM Novel Effectors of Energy Metabolism Room: Quandary Peak Discuss novel pathways/factors that regulate energy expenditure in adipose or skeletal muscle. Speaker 4 of 5 Jiandie Lin, University of Michigan Medical School, USA Endocrine Checkpoint for NASH Progression
Thursday, January 25 \| 5:00PM - 6:45PM Novel Effectors of Energy Metabolism Room: Quandary Peak Discuss novel pathways/factors that regulate energy expenditure in adipose or skeletal muscle. Speaker 5 of 5 Ajay Chawla, Merck Research Labs, USA Host Immunity and Energetics
Thursday, January 25 \| 5:00PM - 6:45PM Fat on the Brain: Adipose-Brain Crosstalk This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 1 of 4 * Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Thursday, January 25 \| 5:00PM - 6:45PM Fat on the Brain: Adipose-Brain Crosstalk This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 2 of 4 Gary J. Schwartz, Albert Einstein College of Medicine, USA Metabolic Sensing in Adipose Tissue Nerves
Thursday, January 25 \| 5:00PM - 6:45PM Fat on the Brain: Adipose-Brain Crosstalk This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 3 of 4 Pierre Léopold, Institut Curie, Paris, France Humoral Communication between Fat and Brain in Drosophila
Thursday, January 25 \| 5:00PM - 6:45PM Fat on the Brain: Adipose-Brain Crosstalk This session is from Obesity and NAFLD Room: Grays/Longs Peak Speaker 4 of 4 Suneil K. Koliwad, University of California, San Francisco, USA Hypothalamic Microglia as Fat Sensors: Physiology vs. Pathology
Thursday, January 25 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Quandary Peak
Thursday, January 25 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) This session is from Obesity and NAFLD Room: Grays/Longs Peak
Thursday, January 25 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Thursday, January 25 \| 8:00PM - 11:00PM Entertainment Room: Colorado Rockies Ballroom Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, January 25 \| 8:00PM - 11:00PM Cash Bar Room: Colorado Rockies Ballroom
Friday, January 26 \| 10:24AM - 10:24AM Departure *Session Chair.