Web Desc
Vascular Biology and Human Diseases: From Molecular Pathways to Novel Therapeutics
joint with Uncomplicating Diabetes: Reducing the Burden of Diabetes-Related End-Organ Injury
Organizer(s): Elisabetta Dejana, Anne C. Eichmann and Gavin O. Thurston
Date: February 25 - March 01, 2018
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Sponsored by Regeneron Pharmaceuticals, Inc.
Summary of Meeting:
Recent years have seen rapid progress in our knowledge of how the vascular system is formed during embryo development and in adults expressing in proliferative diseases such as cancer. It has become unequivocally evident that endothelial cells express highly specific and distinct functions in arteries, veins and lymphatics. Moreover, endothelial cells are able to further modify their functional properties in order to meet the specific needs of the different organs. This conference will address the mechanisms that orchestrate organ-specific endothelial differentiation, making a connection between endothelial dysfunction and organ pathology. The major challenge will be to link our experimental knowledge to the understanding of human vascular diseases. The symposium will bring together teams of vascular biologists, neuroscientists, immunologists and clinicians from all over the world to share their recent discoveries and to direct future efforts to find novel and more precise therapies.
Scholarship Deadline: November 16 2017
Discounted Abstract Deadline: November 16 2017
Abstract Deadline: November 28 2017
Discounted Registration Deadline: December 20 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Regeneron Pharmaceuticals, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1 R13 HL140903-01
Funding for this conference was made possible (in part) by 1 R13 HL140903-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 25 | 4:00PM - 8:00PM
Arrival and Registration
Room: Eldorado Lounge


Sunday, February 25 | 6:00PM - 8:00PM
Welcome Mixer
Room: Eldorado Lounge
No registration fees are used to fund alcohol served at this function.

Monday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Monday, February 26 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado A

Speaker 1 of 2
* Elisabetta Dejana, Uppsala University, Sweden

Monday, February 26 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado A

Speaker 2 of 2
Kari K. Alitalo, University of Helsinki, Finland
Therapeutic Potential of Vascular Growth Factors

Monday, February 26 | 9:00AM - 11:30AM
Vascular Growth Factors: Biological Relevance and Therapeuti
c Application

Room: Eldorado A

Speaker 1 of 7
* Anne C. Eichmann, Yale University School of Medicine, USA

Monday, February 26 | 9:00AM - 11:30AM
Vascular Growth Factors: Biological Relevance and Therapeuti
c Application

Room: Eldorado A

Speaker 2 of 7
Michael Simons, Yale University, USA
Cell Type Specificity of FGF/TGF Signaling

Monday, February 26 | 9:00AM - 11:30AM
Vascular Growth Factors: Biological Relevance and Therapeuti
c Application

Room: Eldorado A


Coffee Break

Monday, February 26 | 9:00AM - 11:30AM
Vascular Growth Factors: Biological Relevance and Therapeuti
c Application

Room: Eldorado A

Speaker 4 of 7
Lena Claesson-Welsh, Uppsala University, Sweden
Vascular Leakage in Cancer and Retinopathy

Monday, February 26 | 9:00AM - 11:30AM
Vascular Growth Factors: Biological Relevance and Therapeuti
c Application

Room: Eldorado A

Speaker 5 of 7
Shahin Rafii, Weill Cornell Medical College, USA
Ultradian Vascular Niche Signals in Organotypic Stem Cell Regeneration

Monday, February 26 | 9:00AM - 11:30AM
Vascular Growth Factors: Biological Relevance and Therapeuti
c Application

Room: Eldorado A

Speaker 6 of 7
Anna I. Dimberg, Uppsala University Hospital, Sweden
Short Talk: CD93 in Regulation of Tumor Angiogenesis

Monday, February 26 | 9:00AM - 11:30AM
Vascular Growth Factors: Biological Relevance and Therapeuti
c Application

Room: Eldorado A

Speaker 7 of 7
Roxana Ola, Yale University, USA
Short Talk: Smad4 Acts Downstream of BMP9/10-ALK1 in Mediating AVM Formation through Transcriptional Modulation of CK2/PTEN/PI3K Signaling Cascade

Monday, February 26 | 9:00AM - 11:30AM
New Treatments in Diabetes
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 1 of 7
* Mark I. McCarthy, University of Oxford, UK


Monday, February 26 | 9:00AM - 11:30AM
New Treatments in Diabetes
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 2 of 7
Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute, Canada
GLP-1-Mediated Reduction in Complications of Diabetes


Monday, February 26 | 9:00AM - 11:30AM
New Treatments in Diabetes
This session is from Uncomplicating Diabetes
Room: Eldorado B


Coffee Break


Monday, February 26 | 9:00AM - 11:30AM
New Treatments in Diabetes
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 4 of 7
Volker Vallon, University of California, San Diego, USA
SGLT2 Inhibition – Insights from Experimental Studies


Monday, February 26 | 9:00AM - 11:30AM
New Treatments in Diabetes
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 5 of 7
David Cherney, University of Toronto, Canada
SGLT2 Inhibition: Renal Effects in Man


Monday, February 26 | 9:00AM - 11:30AM
New Treatments in Diabetes
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 6 of 7
* Simeon Taylor, University of Maryland School of Medicine, USA
Short Talk: Canagliflozin Triggers the FGF23/1,25-dihydroxyvitamin/PTH Axis: A Potential Mechanism Mediating Adverse Effects on Bone Health


Monday, February 26 | 9:00AM - 11:30AM
New Treatments in Diabetes
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 7 of 7
Anita C. Aperia, Karolinska Institute, Sweden
Short Talk: Vulnerability of SGLT-Expressing Cells to Hyperglycaemia


Monday, February 26 | 11:30AM - 5:00PM
On Own for Lunch


Monday, February 26 | 11:30AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Monday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Monday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Monday, February 26 | 5:00PM - 7:00PM
Vascular Growth Factors: Receptors and Biological Role
Room: Eldorado A

Speaker 1 of 5
* Lena Claesson-Welsh, Uppsala University, Sweden

Monday, February 26 | 5:00PM - 7:00PM
Vascular Growth Factors: Receptors and Biological Role
Room: Eldorado A

Speaker 2 of 5
Gou Young Koh, Institute of Basic Science, South Korea
Tie2-Activating Antibody “ABTAA” for Micro-vascular Diseases

Monday, February 26 | 5:00PM - 7:00PM
Vascular Growth Factors: Receptors and Biological Role
Room: Eldorado A

Speaker 3 of 5
Gavin O. Thurston, Regeneron Pharmaceuticals Inc., USA
Tumor Endothelial Cell Heterogeneity and Responses to Anti-Vascular Therapy

Monday, February 26 | 5:00PM - 7:00PM
Vascular Growth Factors: Receptors and Biological Role
Room: Eldorado A

Speaker 4 of 5
Luisa Iruela-Arispe, University of California, Los Angeles, USA
Critical Signaling Nodes in Vascular Homeostasis

Monday, February 26 | 5:00PM - 7:00PM
Vascular Growth Factors: Receptors and Biological Role
Room: Eldorado A

Speaker 5 of 5
Hong Chen, Harvard Medical School, USA
Short Talk: Epsin’s Role in Diabetic Lymphanagiogenesis

Monday, February 26 | 5:00PM - 7:00PM
Lipids and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 1 of 5
* Moshe Levi, Georgetown University, USA


Monday, February 26 | 5:00PM - 7:00PM
Lipids and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 2 of 5
* Josephine Forbes, University of Queensland, Australia


Monday, February 26 | 5:00PM - 7:00PM
Lipids and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 3 of 5
Katalin Susztak, University of Pennsylvania, USA
How to Turn GWAS Signals into Drugs for Kidney Disease?


Monday, February 26 | 5:00PM - 7:00PM
Lipids and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 4 of 5
Weier Qi, Joslin Diabetes Center, Harvard Medical School, Boston, USA, Sweden
Human Proteomics to Therapeutics for Diabetic Nephropathy - The 50-Year Joslin Medalist Study


Monday, February 26 | 5:00PM - 7:00PM
Lipids and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 5 of 5
Eoin P. Brennan, Conway Institute, Ireland
Short Talk: Targeting Inflammation in Diabetic Kidney Disease Using Pro-Resolving Lipid Mediators


Monday, February 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, February 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Anasazi Ballroom


Tuesday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Tuesday, February 27 | 8:00AM - 11:15AM
Endothelial Metabolism and Neurovascular Cross-Talk (Joint)
Room: Eldorado Grand Ballroom

Speaker 1 of 9
* George L. King, Joslin Diabetes Center, USA

Tuesday, February 27 | 8:00AM - 11:15AM
Endothelial Metabolism and Neurovascular Cross-Talk (Joint)
Room: Eldorado Grand Ballroom

Speaker 2 of 9
* Luisa Iruela-Arispe, University of California, Los Angeles, USA

Tuesday, February 27 | 8:00AM - 11:15AM
Endothelial Metabolism and Neurovascular Cross-Talk (Joint)
Room: Eldorado Grand Ballroom

Speaker 3 of 9
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Endothelial Cell Metabolism and Therapeutic Interventions

Tuesday, February 27 | 8:00AM - 11:15AM
Endothelial Metabolism and Neurovascular Cross-Talk (Joint)
Room: Eldorado Grand Ballroom

Speaker 4 of 9
Susan Quaggin, Northwestern University, USA
VE-PTP Phosphatase Inhibition Protects the Kidney in Diabetes

Tuesday, February 27 | 8:00AM - 11:15AM
Endothelial Metabolism and Neurovascular Cross-Talk (Joint)
Room: Eldorado Grand Ballroom


Coffee Break

Tuesday, February 27 | 8:00AM - 11:15AM
Endothelial Metabolism and Neurovascular Cross-Talk (Joint)
Room: Eldorado Grand Ballroom

Speaker 6 of 9
Anne C. Eichmann, Yale University School of Medicine, USA
Neurovascular Cross-Talk and Possible Pathological Implications

Tuesday, February 27 | 8:00AM - 11:15AM
Endothelial Metabolism and Neurovascular Cross-Talk (Joint)
Room: Eldorado Grand Ballroom

Speaker 7 of 9
David L. Silver, Duke-NUS Medical School, Singapore
Brain Lipid Transport

Tuesday, February 27 | 8:00AM - 11:15AM
Endothelial Metabolism and Neurovascular Cross-Talk (Joint)
Room: Eldorado Grand Ballroom

Speaker 8 of 9
Kevin G. Peters, Aerpio Pharmaceuticals, USA
Short Talk: Targeting VE-PTP for Tie2 Activation and Vascular Stabilization in Diabetic Eye Disease

Tuesday, February 27 | 8:00AM - 11:15AM
Endothelial Metabolism and Neurovascular Cross-Talk (Joint)
Room: Eldorado Grand Ballroom

Speaker 9 of 9
Jacqueline A. Taylor, German Cancer Research Center, Germany
Short Talk: Endothelial Notch1 Is a Potent Regulator of Adipose Tissue Metabolism and Function

Tuesday, February 27 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, February 27 | 11:15AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Tuesday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Tuesday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Tuesday, February 27 | 5:00PM - 7:00PM
Regulation of Endothelial Cell Differentiation in Developmen
t and Tissue Regeneration

Room: Eldorado A

Speaker 1 of 5
* Ralf H. Adams, Max Planck Institute for Molecular Biomedicine, Germany

Tuesday, February 27 | 5:00PM - 7:00PM
Regulation of Endothelial Cell Differentiation in Developmen
t and Tissue Regeneration

Room: Eldorado A

Speaker 2 of 5
Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany
Vascular Development in Zebrafish

Tuesday, February 27 | 5:00PM - 7:00PM
Regulation of Endothelial Cell Differentiation in Developmen
t and Tissue Regeneration

Room: Eldorado A

Speaker 3 of 5
Taija Mäkinen, Uppsala University, Sweden
Mechanisms of Lymphatic Vessel Formation from Progenitors of Different Origins

Tuesday, February 27 | 5:00PM - 7:00PM
Regulation of Endothelial Cell Differentiation in Developmen
t and Tissue Regeneration

Room: Eldorado A

Speaker 4 of 5
Hellmut G. Augustin, DKFZ & Heidelberg University, Germany
Epigenetic Regulation of Vascular Maturation

Tuesday, February 27 | 5:00PM - 7:00PM
Regulation of Endothelial Cell Differentiation in Developmen
t and Tissue Regeneration

Room: Eldorado A

Speaker 5 of 5
Katsuhiro Kato, Max Planck Institute for Molecular Biomedicine, Germany
Short Talk: Pulmonary Pericytes Regulate Lung Morphogenesis

Tuesday, February 27 | 5:00PM - 7:15PM
Mitochondria and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 1 of 6
* Kumar Sharma, USA


Tuesday, February 27 | 5:00PM - 7:15PM
Mitochondria and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 2 of 6
* Assaad Antoine Eid, American University of Beirut, Lebanon


Tuesday, February 27 | 5:00PM - 7:15PM
Mitochondria and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 3 of 6
Richard J. Youle, NINDS, National Institutes of Health, USA
General Overview on Mito Maven


Tuesday, February 27 | 5:00PM - 7:15PM
Mitochondria and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 4 of 6
Chengxue Helena Qin, Baker IDI Heart and Diabetes Institute, Australia
Role of Endogenous Annexin-A1 in the Cardiovascular Response to Diabetes


Tuesday, February 27 | 5:00PM - 7:15PM
Mitochondria and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 5 of 6
Farhad Danesh, University of Texas MD Anderson Cancer Center, USA
Mitochondrial Reprogramming in Diabetic Nephropathy


Tuesday, February 27 | 5:00PM - 7:15PM
Mitochondria and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 6 of 6
Svati H. Shah, Duke University, USA
What Can We Learn from Metabolomics?


Tuesday, February 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, February 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Anasazi Ballroom


Wednesday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Wednesday, February 28 | 8:00AM - 11:15AM
Molecular Basis of Vascular Diversity
Room: Eldorado A

Speaker 1 of 8
* Hellmut G. Augustin, DKFZ & Heidelberg University, Germany

Wednesday, February 28 | 8:00AM - 11:15AM
Molecular Basis of Vascular Diversity
Room: Eldorado A

Speaker 2 of 8
Ralf H. Adams, Max Planck Institute for Molecular Biomedicine, Germany
Organ-Specific and Functional Specialization of Blood Vessels

Wednesday, February 28 | 8:00AM - 11:15AM
Molecular Basis of Vascular Diversity
Room: Eldorado A

Speaker 3 of 8
Costantino Iadecola, Weill Cornell Medicine, USA
The Diversity of the Brain Microcirculation in Health and Disease

Wednesday, February 28 | 8:00AM - 11:15AM
Molecular Basis of Vascular Diversity
Room: Eldorado A


Coffee Break

Wednesday, February 28 | 8:00AM - 11:15AM
Molecular Basis of Vascular Diversity
Room: Eldorado A

Speaker 5 of 8
Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland
Specialized Brain Barriers Establish the Immune Privilege of the CNS

Wednesday, February 28 | 8:00AM - 11:15AM
Molecular Basis of Vascular Diversity
Room: Eldorado A

Speaker 6 of 8
Stefan Liebner, Klinikum der Johann Wolfgang Goethe-Universität, Germany
Role of Astrocyte-derived Wnt Growth Factors for Endothelial Blood-brain Barrier Maintenance

Wednesday, February 28 | 8:00AM - 11:15AM
Molecular Basis of Vascular Diversity
Room: Eldorado A

Speaker 7 of 8
Marco Castro, Uppsala University, Sweden
Short Talk: Endothelial Loss of CDC42 Elicits Cerebral Vascular Malformations and Increases MEKK3-Dependent KLF2/4 Expression

Wednesday, February 28 | 8:00AM - 11:15AM
Molecular Basis of Vascular Diversity
Room: Eldorado A

Speaker 8 of 8
Joseph M. Rutkowski, Texas A&M College of Medicine, USA
Short Talk: Enhancing Renal Lymphatic Expansion Prevents Hypertension in Mice

Wednesday, February 28 | 8:00AM - 11:00AM
Genomics and Epigenomics in Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 1 of 7
* Katalin Susztak, University of Pennsylvania, USA


Wednesday, February 28 | 8:00AM - 11:00AM
Genomics and Epigenomics in Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 2 of 7
* Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA


Wednesday, February 28 | 8:00AM - 11:00AM
Genomics and Epigenomics in Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 3 of 7
Eske Willerslev, University of Copenhagen, Denmark
DNA Research on Indigenous Populations


Wednesday, February 28 | 8:00AM - 11:00AM
Genomics and Epigenomics in Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 4 of 7
Mark I. McCarthy, University of Oxford, UK
Using Human Genetics for Biological Insight and Translational Advantage


Wednesday, February 28 | 8:00AM - 11:00AM
Genomics and Epigenomics in Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B


Coffee Break


Wednesday, February 28 | 8:00AM - 11:00AM
Genomics and Epigenomics in Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 6 of 7
Ariela Benigni, Istituto di Ricerche Farmacologiche Mario Negri, Italy
Regeneration of Kidney Vasculature by Angiotensin II Antagonism: New Insights


Wednesday, February 28 | 8:00AM - 11:00AM
Genomics and Epigenomics in Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 7 of 7
Assam El-Osta, Monash University, Australia
Epigenetics of Diabetes and its Complications: Beyond Epiphenomenon?


Wednesday, February 28 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, February 28 | 11:15AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Wednesday, February 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Wednesday, February 28 | 2:30PM - 4:30PM
Workshop: Blood-Brain Barrier Development and Maintenance in
Health and Disease
Room: Eldorado A

Speaker 1 of 10
* Dritan Agalliu, Columbia University Medical Center, USA

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop: Blood-Brain Barrier Development and Maintenance in
Health and Disease
Room: Eldorado A

Speaker 2 of 10
* Peetra Ulrica Magnusson, Uppsala University, Sweden

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop: Blood-Brain Barrier Development and Maintenance in
Health and Disease
Room: Eldorado A

Speaker 3 of 10
Ruchi Bajpai, University of Southern California, USA
Cranial Pericytes Derived from Neural Crest Cells Reveal a Pericyte-Specific Functional Defect in Alzheimer’s Disease

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop: Blood-Brain Barrier Development and Maintenance in
Health and Disease
Room: Eldorado A

Speaker 4 of 10
Ayal Ben-Zvi, Hebrew University of Jerusalem, Israel
Brain Barrier Pathology in Neuropsychiatric Lupus (NPSLE)

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop: Blood-Brain Barrier Development and Maintenance in
Health and Disease
Room: Eldorado A

Speaker 5 of 10
Lei Liu Conze, Uppsala University, Sweden
Dynamic Molecular Signatures of Cerebral Blood Vessel during Blood Brain Barrier Development

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop: Blood-Brain Barrier Development and Maintenance in
Health and Disease
Room: Eldorado A

Speaker 6 of 10
Selasi Dankwa, Center for Infectious Disease Research, USA
Identifying Host Kinases and Inhibitors that Regulate Barrier Properties in Human Brain Endothelial Cells

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop: Blood-Brain Barrier Development and Maintenance in
Health and Disease
Room: Eldorado A

Speaker 7 of 10
Louise Delsing, University of Skövde, Sweden
A Human iPSC-Derived Model to Investigate Blood-Brain Barrier Specification of Endothelial Cells

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop: Blood-Brain Barrier Development and Maintenance in
Health and Disease
Room: Eldorado A

Speaker 8 of 10
Evelyn M. Hoover, University of California, Irvine, USA
The Vascular Immune Response to Infection Differs in the Brain and the Periphery

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop: Blood-Brain Barrier Development and Maintenance in
Health and Disease
Room: Eldorado A

Speaker 9 of 10
Andrei V. Karginov, University of Illinois at Chicago, USA
Barrier-Enhancing Function of Src Kinase in Endothelial Cells

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop: Blood-Brain Barrier Development and Maintenance in
Health and Disease
Room: Eldorado A

Speaker 10 of 10
Joppe Oldenburg, Uppsala University, Sweden
Identifying Novel Small Molecule Drugs for Cerebral Cavernous Malformation Treatment

Wednesday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Wednesday, February 28 | 5:00PM - 7:00PM
Oxidative Stress and Diabetic Complications
Room: Eldorado B

Speaker 1 of 5
* Costantino Iadecola, Weill Cornell Medicine, USA

Wednesday, February 28 | 5:00PM - 7:00PM
Oxidative Stress and Diabetic Complications
Room: Eldorado B

Speaker 2 of 5
Christer Betsholtz, Uppsala University, Sweden
A Molecular Atlas of the Blood-Brain Barrier as Revealed by Single Cell RNA Sequencing and Quantitative Proteomics

Wednesday, February 28 | 5:00PM - 7:00PM
Oxidative Stress and Diabetic Complications
Room: Eldorado B

Speaker 3 of 5
Elisabetta Dejana, Uppsala University, Sweden
Transcriptional Regulation of the Blood-Brain Barrier in Health and Disease

Wednesday, February 28 | 5:00PM - 7:00PM
Oxidative Stress and Diabetic Complications
Room: Eldorado B

Speaker 4 of 5
Dritan Agalliu, Columbia University Medical Center, USA
Cell Biological Mechanisms of Blood-Brain Barrier Breakdown in Neurological Disease

Wednesday, February 28 | 5:00PM - 7:00PM
Oxidative Stress and Diabetic Complications
Room: Eldorado B

Speaker 5 of 5
Monica Manglani, NINDS, National Institutes of Health, USA
Short Talk: Peptide-Specific Engagement of Cerebrovascular Endothelial Cells Promotes Dysfunctional Calcium Signaling during Experimental Cerebral Malaria

Wednesday, February 28 | 5:00PM - 7:00PM
Mitochondria and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 1 of 6
* Charles E. Alpers, University of Washington, USA


Wednesday, February 28 | 5:00PM - 7:00PM
Mitochondria and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 2 of 6
* Farhad Danesh, University of Texas MD Anderson Cancer Center, USA


Wednesday, February 28 | 5:00PM - 7:00PM
Mitochondria and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 3 of 6
Patrick J. Pagano, University of Pittsburgh, USA
ROS in Vascular Phenotypic Switching and Disease, Target Nox!


Wednesday, February 28 | 5:00PM - 7:00PM
Mitochondria and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 4 of 6
Karin Agnes Maria Jandeleit-Dahm, Monash University, Australia
The Role of Reactive Oxygen Species in Diabetic Complications


Wednesday, February 28 | 5:00PM - 7:00PM
Mitochondria and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 5 of 6
Kumar Sharma, USA
Mitochondrial ROS: Friend or Foe?


Wednesday, February 28 | 5:00PM - 7:00PM
Mitochondria and Diabetic Complications
This session is from Uncomplicating Diabetes
Room: Eldorado B

Speaker 6 of 6
Jay C. Jha, Monash University, Australia
Short Talk: NADPH-Oxidase NOX5 Aggravates Renal Injury in Human Diabetic Nephropathy


Wednesday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, February 28 | 7:30PM - 10:00PM
Poster Session 3
Room: Anasazi Ballroom


Thursday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Thursday, March 01 | 8:00AM - 11:45AM
Inflammation, the Vasculature and Diabetic Complications (Jo
int)

Room: Eldorado Grand Ballroom

Speaker 1 of 11
* Anil Karihaloo, Novo Nordisk A/S, USA

Thursday, March 01 | 8:00AM - 11:45AM
Inflammation, the Vasculature and Diabetic Complications (Jo
int)

Room: Eldorado Grand Ballroom

Speaker 2 of 11
* Michael Simons, Yale University, USA

Thursday, March 01 | 8:00AM - 11:45AM
Inflammation, the Vasculature and Diabetic Complications (Jo
int)

Room: Eldorado Grand Ballroom

Speaker 3 of 11
Andrew J. Murphy, Baker Heart Research Institute, Australia
Hematopoietic Progenitor Cells in Diabetic Complications

Thursday, March 01 | 8:00AM - 11:45AM
Inflammation, the Vasculature and Diabetic Complications (Jo
int)

Room: Eldorado Grand Ballroom

Speaker 4 of 11
Mark E. Cooper, Monash University, Australia
An Unrecognized Role for the Adaptive Immune System in Vision-Threatening Neovascular Retinopathies

Thursday, March 01 | 8:00AM - 11:45AM
Inflammation, the Vasculature and Diabetic Complications (Jo
int)

Room: Eldorado Grand Ballroom


Coffee Break

Thursday, March 01 | 8:00AM - 11:45AM
Inflammation, the Vasculature and Diabetic Complications (Jo
int)

Room: Eldorado Grand Ballroom

Speaker 6 of 11
Martin Schwartz, Yale School of Medicine, USA
Endothelial Fluid Shear Stress Responses in Vascular Remodeling and Atherosclerosis

Thursday, March 01 | 8:00AM - 11:45AM
Inflammation, the Vasculature and Diabetic Complications (Jo
int)

Room: Eldorado Grand Ballroom

Speaker 7 of 11
Thomas J. Schall, ChemoCentryx, Inc., USA
Targeting CCR2 for the Treatment of Renal Diseases

Thursday, March 01 | 8:00AM - 11:45AM
Inflammation, the Vasculature and Diabetic Complications (Jo
int)

Room: Eldorado Grand Ballroom

Speaker 8 of 11
Kyung Lee, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Leucine Rich alpha-2-Glycoprotein 1 (LRG1) Is Increased in Diabetic Kidneys and Is a Driver of Angiogenesis and Progression of Diabetic Glomerulopathy

Thursday, March 01 | 8:00AM - 11:45AM
Inflammation, the Vasculature and Diabetic Complications (Jo
int)

Room: Eldorado Grand Ballroom

Speaker 9 of 11
Jill Badin, Indiana University School of Medicine, USA
Short Talk: Diabetes Exacerbates Coronary Atherosclerosis and Calcification in Ossabaw Miniature Swine with Metabolic Syndrome

Thursday, March 01 | 8:00AM - 11:45AM
Inflammation, the Vasculature and Diabetic Complications (Jo
int)

Room: Eldorado Grand Ballroom

Speaker 10 of 11
Ingrid Fleming, Goethe University Frankfurt, Germany
Short Talk: Inhibition of Soluble Epoxide Hydrolase Prevents Diabetic Retinopathy

Thursday, March 01 | 8:00AM - 11:45AM
Inflammation, the Vasculature and Diabetic Complications (Jo
int)

Room: Eldorado Grand Ballroom

Speaker 11 of 11
Reiner Alois Wimmer, Institute of Molecular Biotechnology Austria, Austria
Short Talk: Human Blood Vessel Organoids: A New Model for Diabetic Vasculopathy

Thursday, March 01 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, March 01 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Thursday, March 01 | 5:00PM - 7:15PM
Vasoactive Hormones in Diabetic Complications/Hemodynamics a
nd Endothelial Pathology (Joint)

Room: Eldorado Ballroom

Speaker 1 of 6
* Christer Betsholtz, Uppsala University, Sweden

Thursday, March 01 | 5:00PM - 7:15PM
Vasoactive Hormones in Diabetic Complications/Hemodynamics a
nd Endothelial Pathology (Joint)

Room: Eldorado Ballroom

Speaker 2 of 6
* Susan Quaggin, Northwestern University, USA

Thursday, March 01 | 5:00PM - 7:15PM
Vasoactive Hormones in Diabetic Complications/Hemodynamics a
nd Endothelial Pathology (Joint)

Room: Eldorado Ballroom

Speaker 3 of 6
Rama Natarajan, Beckman Research Institute of City of Hope, USA
Linking LncRNAs with Diabetic Complications and Angiotensin II Actions

Thursday, March 01 | 5:00PM - 7:15PM
Vasoactive Hormones in Diabetic Complications/Hemodynamics a
nd Endothelial Pathology (Joint)

Room: Eldorado Ballroom

Speaker 4 of 6
Susan Gurley, Oregon Health and Science University, USA
Angiotensin II: Tissue-Selective Effects

Thursday, March 01 | 5:00PM - 7:15PM
Vasoactive Hormones in Diabetic Complications/Hemodynamics a
nd Endothelial Pathology (Joint)

Room: Eldorado Ballroom

Speaker 5 of 6
Merlin Christopher Thomas, Monash University, Australia
Novel Interactions with the Receptor for Advanced Glycation End-products in Mediating Pro-inflammatory Signalling

Thursday, March 01 | 5:00PM - 7:15PM
Vasoactive Hormones in Diabetic Complications/Hemodynamics a
nd Endothelial Pathology (Joint)

Room: Eldorado Ballroom

Speaker 6 of 6
Tatiana V. Petrova, CHUV, University of Lausanne, Switzerland
Endothelial Cell Responses to Biomechanical Forces in Lymphatics

Thursday, March 01 | 7:15PM - 7:30PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
(Joint)

Room: Eldorado Ballroom


Thursday, March 01 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, March 01 | 8:00PM - 11:00PM
Entertainment
Room: Anasazi Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 01 | 8:00PM - 11:00PM
Cash Bar
Room: Anasazi Ballroom


Friday, March 02 | 10:24AM - 10:24AM
Departure


*Session Chair.