Web Desc
Antimicrobials and Resistance: Opportunities and Challenges
Organizer(s): Gautam Dantas and Jennifer A. Leeds
Date: October 29 - November 01, 2017
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Supported by the Directors' Fund
Summary of Meeting:
Antimicrobial-resistant (AMR) infections claim numerous lives around the globe annually. This problem is exacerbated by a steady increase in global antimicrobial use and abuse in the clinic and agriculture, and a dearth of novel antimicrobials making it to market. If these scenarios continue unchecked, AMR will cumulatively cost the global economy around 100 trillion dollars by 2050. This conference focuses on the latest work understanding and combatting AMR, including clinical perspectives on AMR diagnostics and management, translational academic perspectives on design of drug regimens and combinations that suppress AMR, pharma perspectives on recent successes and failures in novel antimicrobial development and clinical trials and basic science perspectives on the ecology and transmission of evolving AMR determinants. While these stakeholders are similarly motivated to identify and develop therapies to treat the exceptional, unmet medical need of worsening AMR, their spheres rarely overlap at scientific conferences, leading to communication barriers between subject matter experts. This conference attempts to address this challenge by engaging diverse global perspectives on these topics, including speakers and attendees from academic research, industrial drug development, and healthcare practice and policy.
Scholarship Deadline: June 27 2017
Discounted Abstract Deadline: June 27 2017
Abstract Deadline: July 27 2017
Discounted Registration Deadline: August 29 2017
We gratefully acknowledge additional support for this conference from:

ACS Infectious Diseases
Forge Therapeutics, Inc.Spero Therapeutics
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Achaogen

Entasis Therapeutics

Spero Therapeutics
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI134087-01
Funding for this conference was made possible (in part) by 1R13AI134087-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, October 29 | 4:00PM - 8:00PM
Arrival and Registration
Room: Eldorado Lounge


Sunday, October 29 | 6:00PM - 8:00PM
Welcome Mixer
Room: Eldorado Lounge
No registration fees are used to fund alcohol served at this function.

Monday, October 30 | 7:30AM - 8:30AM
Breakfast
Room: Eldorado B


Monday, October 30 | 8:00AM - 8:30AM
Poster Setup
Room: Eldorado B


Monday, October 30 | 8:00AM - 5:00PM
Poster Viewing
Room: Eldorado B


Monday, October 30 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Eldorado A

Speaker 1 of 2
* Gautam Dantas, Washington University School of Medicine, USA

Monday, October 30 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Eldorado A

Speaker 2 of 2
Ramanan Laxminarayan, Center for Disease Dynamics, Economics and Policy, India
Antimicrobial Resistance: Managing a Shared Global Resource

Monday, October 30 | 9:30AM - 12:00PM
Surveillance and Treatment of Resistant Bacterial Infections
in Clinical Practice

Room: Eldorado A

Speaker 1 of 7
* Gavin Barlow, Hull and East Yorkshire Hospitals NHS Trust and University of York, UK

Monday, October 30 | 9:30AM - 12:00PM
Surveillance and Treatment of Resistant Bacterial Infections
in Clinical Practice

Room: Eldorado A

Speaker 2 of 7
Michael J. Satlin, Weill Cornell Medicine, USA
Clinical Challenges in Treating Patients with Multidrug-Resistant Bacterial Infections

Monday, October 30 | 9:30AM - 12:00PM
Surveillance and Treatment of Resistant Bacterial Infections
in Clinical Practice

Room: Eldorado A


Coffee Break

Monday, October 30 | 9:30AM - 12:00PM
Surveillance and Treatment of Resistant Bacterial Infections
in Clinical Practice

Room: Eldorado A

Speaker 4 of 7
Carey-Ann D. Burnham, Washington University School of Medicine, USA
Next-Generation Diagnostics: Translating Rapid Pathogen and Resistance Detection to Optimal Antibiotic Prescription

Monday, October 30 | 9:30AM - 12:00PM
Surveillance and Treatment of Resistant Bacterial Infections
in Clinical Practice

Room: Eldorado A

Speaker 5 of 7
Calvin Brown, University of California, Los Angeles, USA
Short Talk: Automated Diagnosis of Antimicrobial Resistance Using a Mobile Phone-Based Well-Plate Reader

Monday, October 30 | 9:30AM - 12:00PM
Surveillance and Treatment of Resistant Bacterial Infections
in Clinical Practice

Room: Eldorado A

Speaker 6 of 7
Jean Patel, Centers for Disease Control and Prevention, USA
Combatting Antibiotic-Resistant Bacteria: CDC’s Implementation of the National Action Plan

Monday, October 30 | 9:30AM - 12:00PM
Surveillance and Treatment of Resistant Bacterial Infections
in Clinical Practice

Room: Eldorado A

Speaker 7 of 7
George A. Cortina, University of Virginia, USA
Short Talk: Predicting Allosteric Mutations that Increase Esbl-Mediated Antibiotic Resistance

Monday, October 30 | 12:00PM - 12:45PM
Lunch
Room: Eldorado B


Monday, October 30 | 12:00PM - 2:30PM
Poster Session 1
Room: Eldorado B


Monday, October 30 | 2:30PM - 4:30PM
Workshop 1: Novel Therapeutic Strategies
Room: Eldorado A

Speaker 1 of 8
* Jennifer A. Leeds, Novartis Institutes for BioMedical Research, USA

Monday, October 30 | 2:30PM - 4:30PM
Workshop 1: Novel Therapeutic Strategies
Room: Eldorado A

Speaker 2 of 8
Elizabeth Culp, McMaster University, Canada
Activation of a Cryptic Glycopeptide Antibiotic-Related Biosynthetic Gene Cluster

Monday, October 30 | 2:30PM - 4:30PM
Workshop 1: Novel Therapeutic Strategies
Room: Eldorado A

Speaker 3 of 8
Nagakumar Bharatham, BUGWORKS Research India Private Ltd, India
Discovery of a Novel Class of Anti-Bacterial Agents through an Efflux Mitigation Strategy

Monday, October 30 | 2:30PM - 4:30PM
Workshop 1: Novel Therapeutic Strategies
Room: Eldorado A

Speaker 4 of 8
Alicia Eve Ballok, Massachusetts General Hospital, USA
Small Molecule Inhibitors of the MvfR Quorum Sensing Pathway Reduce Neutrophil Recruitment and Cytotoxicity of Pseudomonas aeruginosa in Mono and Polymicrobial Lung Infection Models

Monday, October 30 | 2:30PM - 4:30PM
Workshop 1: Novel Therapeutic Strategies
Room: Eldorado A

Speaker 5 of 8
Sarah L. Keasey, United States Army Medical Research Institute of Infectious Diseases, USA
Drug-Specific Tolerance Mechanisms within the Proteome of the Persistence Phenotype

Monday, October 30 | 2:30PM - 4:30PM
Workshop 1: Novel Therapeutic Strategies
Room: Eldorado A

Speaker 6 of 8
Liz Sockett, University of Nottingham, UK
Predatory Bacteria: “Living Antibiotics” to Treat Antibiotic-Resistant Gram-Negative Infections

Monday, October 30 | 2:30PM - 4:30PM
Workshop 1: Novel Therapeutic Strategies
Room: Eldorado A

Speaker 7 of 8
Jade Bojkovic, NGM Biopharmaceuticals, USA
Mining the Human Microbiome for Novel Antimicrobials

Monday, October 30 | 2:30PM - 4:30PM
Workshop 1: Novel Therapeutic Strategies
Room: Eldorado A

Speaker 8 of 8
Marvin J. Miller, University of Notre Dame, USA
Syntheses and Studies of Novel Monobactams and other beta-Lactams with Activity Against Gram-Negative Bacteria, including Carbapenemase-Producing Acinetobacter baumannii

Monday, October 30 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Monday, October 30 | 5:00PM - 7:00PM
Fate and Lessons Learned from Recent Drug Development Progra
ms Focused on Resistant Pathogens or Narrow-Spectrum Agents

Room: Eldorado A

Speaker 1 of 5
* Richa Chandra, Novartis Pharmaceuticals, USA

Monday, October 30 | 5:00PM - 7:00PM
Fate and Lessons Learned from Recent Drug Development Progra
ms Focused on Resistant Pathogens or Narrow-Spectrum Agents

Room: Eldorado A

Speaker 2 of 5
Lorraine D. Hernandez, Merck Research Laboratories, USA
Monoclonal Antibody Therapy for the Prevention of Recurrent Clostridium difficile Infections

Monday, October 30 | 5:00PM - 7:00PM
Fate and Lessons Learned from Recent Drug Development Progra
ms Focused on Resistant Pathogens or Narrow-Spectrum Agents

Room: Eldorado A

Speaker 3 of 5
Christopher B. Ford, Seres Therapeutics, USA
Short Talk: Gastrointestinal Tract Microbiome Dynamics Following Treatment with SER-109, an Investigational Oral Microbiome Therapeutic to Reduce the Recurrence of Clostridium difficile infection (CDI)

Monday, October 30 | 5:00PM - 7:00PM
Fate and Lessons Learned from Recent Drug Development Progra
ms Focused on Resistant Pathogens or Narrow-Spectrum Agents

Room: Eldorado A

Speaker 4 of 5
Lynn E. Connolly, Achaogen, USA
Late-Stage Drug Development: Lessons Learned from Running Resistant Pathogen Focused Clinical Trials

Monday, October 30 | 5:00PM - 7:00PM
Fate and Lessons Learned from Recent Drug Development Progra
ms Focused on Resistant Pathogens or Narrow-Spectrum Agents

Room: Eldorado A

Speaker 5 of 5
Paul G. Ambrose, Institute for Clinical Pharmacodynamics, USA
The Future is Combination Antimicrobial Therapy: The Question is a Combination of What?

Monday, October 30 | 7:00PM - 7:00PM
On Own for Dinner


Tuesday, October 31 | 7:30AM - 8:30AM
Breakfast
Room: Eldorado B


Tuesday, October 31 | 8:30AM - 11:30AM
Alternative Approaches to Tackling Resistant Infections
Room: Eldorado A

Speaker 1 of 8
* Matthew Henn, Seres Therapeutics, USA

Tuesday, October 31 | 8:30AM - 11:30AM
Alternative Approaches to Tackling Resistant Infections
Room: Eldorado A

Speaker 2 of 8
Helen I. Zgurskaya, University of Oklahoma, USA
Synergistic Interplays between Active Drug Efflux and Low Permeability Barrier of the Outer Membrane in Antibacterial Activities and Inhibition of Multidrug Efflux Pumps

Tuesday, October 31 | 8:30AM - 11:30AM
Alternative Approaches to Tackling Resistant Infections
Room: Eldorado A

Speaker 3 of 8
Luis Guachalla, Arsanis Biosciences GmbH, Austria
Short Talk: Antibodies Targeting the Lipopolysaccharide O-antigen as a New Approach to Combat Multidrug Resistant Gram-negative Infections

Tuesday, October 31 | 8:30AM - 11:30AM
Alternative Approaches to Tackling Resistant Infections
Room: Eldorado A

Speaker 4 of 8
Konstantin Taganov, Blacksmith Medicines, USA
Short Talk: Activity of Non-Hydroxamate LpxC Inhibitors Against Acinetobacter baumannii

Tuesday, October 31 | 8:30AM - 11:30AM
Alternative Approaches to Tackling Resistant Infections
Room: Eldorado A


Coffee Break

Tuesday, October 31 | 8:30AM - 11:30AM
Alternative Approaches to Tackling Resistant Infections
Room: Eldorado A

Speaker 6 of 8
Scott Hultgren, Washington University School of Medicine, USA
Discovery and Development of Anti-Virulence Therapeutics against UTI Adhesins

Tuesday, October 31 | 8:30AM - 11:30AM
Alternative Approaches to Tackling Resistant Infections
Room: Eldorado A

Speaker 7 of 8
Rahul M. Kohli, University of Pennsylvania, USA
Short Talk: Targeting the SOS Response to Combat Antibiotic Resistance

Tuesday, October 31 | 8:30AM - 11:30AM
Alternative Approaches to Tackling Resistant Infections
Room: Eldorado A

Speaker 8 of 8
Aileen Rubio, Pew Charitable Trusts, USA
Challenges with Animal Models in Advancing Novel Anti-Infectives

Tuesday, October 31 | 11:30AM - 5:00PM
On Own for Lunch


Tuesday, October 31 | 11:30AM - 1:00PM
Poster Setup
Room: Eldorado B


Tuesday, October 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Eldorado B


Tuesday, October 31 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Tuesday, October 31 | 5:00PM - 7:00PM
Multidrug Evolutionary Strategies to Invert Resistance Selec
tion

Room: Eldorado A

Speaker 1 of 5
* Timothy D. Read, Emory University, USA

Tuesday, October 31 | 5:00PM - 7:00PM
Multidrug Evolutionary Strategies to Invert Resistance Selec
tion

Room: Eldorado A

Speaker 2 of 5
Pamela Yeh, University of California, Los Angeles, USA
Higher-Order Drug Combinations and Suppressive Interactions

Tuesday, October 31 | 5:00PM - 7:00PM
Multidrug Evolutionary Strategies to Invert Resistance Selec
tion

Room: Eldorado A

Speaker 3 of 5
Gavin Barlow, Hull and East Yorkshire Hospitals NHS Trust and University of York, UK
Treating Patients with Infections in the 21st Century - Are Antibiotic Cycling and Novel Combinations a Viable Clinical Option?

Tuesday, October 31 | 5:00PM - 7:00PM
Multidrug Evolutionary Strategies to Invert Resistance Selec
tion

Room: Eldorado A

Speaker 4 of 5
Karen Bush, Indiana University, USA
Enzymatic Antimicrobial Resistance and the Search for New Inhibitors

Tuesday, October 31 | 5:00PM - 7:00PM
Multidrug Evolutionary Strategies to Invert Resistance Selec
tion

Room: Eldorado A

Speaker 5 of 5
Adam R. Renslo, University of California, San Francisco, USA
Short Talk: Reversible Carbapenemase Inhibitors Bridge the Serine-Metallo Divide

Tuesday, October 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado B
No registration fees are used to fund alcohol served at this function.

Tuesday, October 31 | 7:30PM - 10:00PM
Poster Session 2
Room: Eldorado B


Wednesday, November 01 | 7:30AM - 8:30AM
Breakfast
Room: Eldorado B


Wednesday, November 01 | 8:30AM - 11:45AM
Ecology and Evolution of AMR Transmission Dynamics Across Ha
bitats

Room: Eldorado A

Speaker 1 of 8
* Michael S. Gilmore, Harvard Medical School, USA

Wednesday, November 01 | 8:30AM - 11:45AM
Ecology and Evolution of AMR Transmission Dynamics Across Ha
bitats

Room: Eldorado A

Speaker 2 of 8
Gautam Dantas, Washington University School of Medicine, USA
Networks of Exchanging Antibiotic Resistance between Commensal, Environmental and Pathogenic Bacteria

Wednesday, November 01 | 8:30AM - 11:45AM
Ecology and Evolution of AMR Transmission Dynamics Across Ha
bitats

Room: Eldorado A

Speaker 3 of 8
Ilana L. Brito, Cornell University, USA
Horizontal Gene Transfer of Antibiotic Resistance in the Gut Microbiome

Wednesday, November 01 | 8:30AM - 11:45AM
Ecology and Evolution of AMR Transmission Dynamics Across Ha
bitats

Room: Eldorado A

Speaker 4 of 8
Brayon Fremin, Stanford University, USA
Short Talk: Assessment of Protein Synthesis in Response to Antibiotic Treatment in the Human Gut Microbiota

Wednesday, November 01 | 8:30AM - 11:45AM
Ecology and Evolution of AMR Transmission Dynamics Across Ha
bitats

Room: Eldorado A


Coffee Break

Wednesday, November 01 | 8:30AM - 11:45AM
Ecology and Evolution of AMR Transmission Dynamics Across Ha
bitats

Room: Eldorado A

Speaker 6 of 8
Gerry D. Wright, McMaster University, Canada
The Resistome and Antimicrobial Discovery

Wednesday, November 01 | 8:30AM - 11:45AM
Ecology and Evolution of AMR Transmission Dynamics Across Ha
bitats

Room: Eldorado A

Speaker 7 of 8
Robert Matthew Cooper, University of California, San Diego, USA
Short Talk: Visualizing and Predicting Horizontal Gene Transfer Enhanced by Neighbor Killing in Biofilms

Wednesday, November 01 | 8:30AM - 11:45AM
Ecology and Evolution of AMR Transmission Dynamics Across Ha
bitats

Room: Eldorado A

Speaker 8 of 8
Kathryn E. Holt, University of Melbourne, Australia
Klebsiella as a Key Trafficker of Antibiotic Resistance Genes

Wednesday, November 01 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, November 01 | 2:30PM - 4:30PM
Workshop 2: Novel Strategies for AMR Discovery, Diagnostics
and Modeling
Room: Eldorado A

Speaker 1 of 7
* Jennifer A. Leeds, Novartis Institutes for BioMedical Research, USA

Wednesday, November 01 | 2:30PM - 4:30PM
Workshop 2: Novel Strategies for AMR Discovery, Diagnostics
and Modeling
Room: Eldorado A

Speaker 2 of 7
Allison K. Guitor, McMaster University, Canada
In-Solution Targeted Capture of Antibiotic Resistance Genes

Wednesday, November 01 | 2:30PM - 4:30PM
Workshop 2: Novel Strategies for AMR Discovery, Diagnostics
and Modeling
Room: Eldorado A

Speaker 3 of 7
Glen P. Carter, University of Melbourne, Australia
The Role of Topical Antibiotics and Biocides in the Emergence of Multidrug-Resistant Staphylococcus aureus

Wednesday, November 01 | 2:30PM - 4:30PM
Workshop 2: Novel Strategies for AMR Discovery, Diagnostics
and Modeling
Room: Eldorado A

Speaker 4 of 7
Petra Éva Szili, Biological Research Centre of the Hungarian Academy of Sciences, Hungary
Bacterial Genome Engineering Deciphers the Evolutionary Background of Antibiotic Resistance in Clinical Pathogens

Wednesday, November 01 | 2:30PM - 4:30PM
Workshop 2: Novel Strategies for AMR Discovery, Diagnostics
and Modeling
Room: Eldorado A

Speaker 5 of 7
Brett E. Etchebarne, Michigan State University, USA
Evaluation of Nucleic Acid Isothermal Amplification Methods for Human Clinical Microbial Infection and Antibiotic Resistance Gene Detection

Wednesday, November 01 | 2:30PM - 4:30PM
Workshop 2: Novel Strategies for AMR Discovery, Diagnostics
and Modeling
Room: Eldorado A

Speaker 6 of 7
Alexei Savchenko, University of Calgary, Canada
Structural and Functional Characterization of the Environmental Antibiotic Resistome Determinants

Wednesday, November 01 | 2:30PM - 4:30PM
Workshop 2: Novel Strategies for AMR Discovery, Diagnostics
and Modeling
Room: Eldorado A

Speaker 7 of 7
Margot A. Zevon, Merck, USA
Fractionation of Gram-Negative Bacteria for Direct Measurement of Compounds in Subcellular Compartments

Wednesday, November 01 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Wednesday, November 01 | 5:00PM - 6:45PM
Tackling AMR - Challenges in Drug Development
Room: Eldorado A

Speaker 1 of 4
* Holly Soutter, discX, USA

Wednesday, November 01 | 5:00PM - 6:45PM
Tackling AMR - Challenges in Drug Development
Room: Eldorado A

Speaker 2 of 4
Thomas F. Durand-Reville, Entasis Therapeutics, USA
New Compound Uptake Tools to Confront the Challenges of MDR Gram-Negative Antibiotic Discovery

Wednesday, November 01 | 5:00PM - 6:45PM
Tackling AMR - Challenges in Drug Development
Room: Eldorado A

Speaker 3 of 4
Folkert Reck, Novartis Institutes for BioMedical Research, USA
LYS228, A Novel Monobactam to Treat Infections Caused by Multidrug-Resistant Enterobacteriaceae

Wednesday, November 01 | 5:00PM - 6:45PM
Tackling AMR - Challenges in Drug Development
Room: Eldorado A

Speaker 4 of 4
Danica Galonic Fujimori, University of California, San Francisco, USA
Peptidyl Transferase Center Methylation in Antibiotic Resistance

Wednesday, November 01 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Eldorado A


Wednesday, November 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado B
No registration fees are used to fund alcohol served at this function.

Wednesday, November 01 | 8:00PM - 11:00PM
Entertainment
Room: Eldorado B
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Wednesday, November 01 | 8:00PM - 11:00PM
Cash Bar
Room: Eldorado B


Thursday, November 02 | 10:24AM - 10:24AM
Departure


*Session Chair.