Web Desc
Therapeutic Targeting of Hypoxia-Sensitive Pathways
Organizer(s): Chris W. Pugh, Pablo Wappner, Johanna Myllyharju and Moira K. Whyte
Date: April 10 - 14, 2018
Location: University of Oxford Mathematical Institute, Oxford, United Kingdom
Sponsored by Akebia Therapeutics
Summary of Meeting:
Tissue oxygen gradients contribute to morphogenesis and in health cells in different tissues function under differing ambient oxygen conditions. Diseases or environmental challenges can reduce oxygen supply or increase demand, resulting in tissue hypoxia. Adaptive mechanisms have evolved that range from almost instantaneous acute ventilatory changes, through transcriptional events entrained in hours, to epigenetic events with slower effects and genetic adaptations selected across species and over generations. The role of the 2-oxoglutarate dependent dioxygenase enzyme family in influencing many, but not all, of these pleiotropic processes is increasingly recognized, and drugs targeting these enzymes are being evaluated in both experimental and clinical settings. The conference aims to combine the Keystone Symposia brand with the European HypoxiaNET consortium to bring together experts in hypoxia biology from clinical, academic and industrial backgrounds, including trainees, to: 1) Address gaps in our knowledge of responses to hypoxia across these time-frames and in different tissues; 2) Benefit the field by sharing techniques and reagents to enhance therapeutic targeting of the hypoxic response in general, including via inhibition of oxygen-sensitive enzymes; 3) Consider the utility of harnessing these pathways in organ dysfunction, in regenerative medicine and to influence immune and inflammatory responses; and 4) Disseminate outcomes of ongoing clinical trials and enhance plans for future trials. The most important anticipated outcome from the conference is that, through sharing knowledge, enhancing collaborations and training participants from diverse backgrounds, the likelihood of successful manipulation of hypoxia pathways to produce clinical benefits in a variety of fields including, but not restricted to, renal anemia will be significantly enhanced.
Scholarship Deadline: December 11 2017
Discounted Abstract Deadline: December 11 2017
Abstract Deadline: January 10 2018
Discounted Registration Deadline: February 13 2018
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Akebia Therapeutics
We gratefully acknowledge additional support from these exhibitors at this conference:
Don Whitley Scientific Limited
We gratefully acknowledge additional support for this conference from:
Baker RuskinnDove Medical Press Ltd
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL142299-01
Funding for this conference was made possible (in part) by 1R13HL142299-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, April 10 | 4:00PM - 8:00PM
Arrival and Registration
Room: South Mezzanine


Tuesday, April 10 | 6:00PM - 8:00PM
Welcome Mixer
Room: South Mezzanine
No registration fees are used to fund alcohol served at this function.

Wednesday, April 11 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Mathematical Institute, L1

Speaker 1 of 5
* Chris W. Pugh, University of Oxford, UK

Wednesday, April 11 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Mathematical Institute, L1

Speaker 2 of 5
* Pablo Wappner, Fundacion Instituto Leloir, Argentina

Wednesday, April 11 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Mathematical Institute, L1

Speaker 3 of 5
* Johanna Myllyharju, University of Oulu, Finland

Wednesday, April 11 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Mathematical Institute, L1

Speaker 4 of 5
* Moira K. Whyte, University of Edinburgh, Queen's Medical Research Institute, UK

Wednesday, April 11 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Mathematical Institute, L1

Speaker 5 of 5
Peter J. Ratcliffe, University of Oxford, UK
New Horizons in Hypoxia Biology and Therapeutics

Wednesday, April 11 | 9:30AM - 12:00PM
Acute Oxygen-Sensing
Room: Mathematical Institute, L1

Speaker 1 of 7
* Roland H. Wenger, University of Zürich, Switzerland

Wednesday, April 11 | 9:30AM - 12:00PM
Acute Oxygen-Sensing
Room: Mathematical Institute, L1

Speaker 2 of 7
Mark A. Krasnow, Stanford University School of Medicine, USA
Acute Oxygen Sensing in the Lungs and Carotid Body

Wednesday, April 11 | 9:30AM - 12:00PM
Acute Oxygen-Sensing
Room: Mathematical Institute, L1


Coffee Break

Wednesday, April 11 | 9:30AM - 12:00PM
Acute Oxygen-Sensing
Room: Mathematical Institute, L1

Speaker 4 of 7
Francesco Licausi, Scuola Superiore Sant'Anna, Italy
Harnessing the Oxygen Sensing Mechanism of Plants

Wednesday, April 11 | 9:30AM - 12:00PM
Acute Oxygen-Sensing
Room: Mathematical Institute, L1

Speaker 5 of 7
Betty A. Eipper, University of Connecticut Health Center, USA
Peptidylglycine alpha–Amidating Monooxygenase (PAM), a Conserved Secretory Pathway Enzyme, Is Sensitive to Physiologically Relevant Changes in Oxygen

Wednesday, April 11 | 9:30AM - 12:00PM
Acute Oxygen-Sensing
Room: Mathematical Institute, L1

Speaker 6 of 7
David Macias, University of Cambridge, UK
Short Talk: HIF-2a Is Essential for Carotid Body Development and Function

Wednesday, April 11 | 9:30AM - 12:00PM
Acute Oxygen-Sensing
Room: Mathematical Institute, L1

Speaker 7 of 7
Christopher Turnbull, University of Oxford, UK
Short Talk: Overnight Supplemental Oxygen Abolishes the Rise in Morning Blood Pressure Caused by CPAP withdrawal in OSA

Wednesday, April 11 | 12:00PM - 5:00PM
On Own for Lunch


Wednesday, April 11 | 12:00PM - 1:00PM
Poster Setup
Room: South Mezzanine


Wednesday, April 11 | 1:00PM - 10:00PM
Poster Viewing
Room: South Mezzanine


Wednesday, April 11 | 2:00PM - 4:30PM
Workshop 1: New Techniques for Oxygen Measurement
Room: Mathematical Institute, L1

Speaker 1 of 6
* Joachim Fandrey, University Duisburg-Essen, Germany

Wednesday, April 11 | 2:00PM - 4:30PM
Workshop 1: New Techniques for Oxygen Measurement
Room: Mathematical Institute, L1

Speaker 2 of 6
Giovanni E. Mann, King's College London, UK
Defining Physiological Normoxia in vitro for Clinical Translation of Cell Physiology

Wednesday, April 11 | 2:00PM - 4:30PM
Workshop 1: New Techniques for Oxygen Measurement
Room: Mathematical Institute, L1

Speaker 3 of 6
Christine Janz, ibidi GmbH, Germany
Intra- and Extracellular Oxygen Measurement on a Live Cell Imaging System Using ibidi OPAL

Wednesday, April 11 | 2:00PM - 4:30PM
Workshop 1: New Techniques for Oxygen Measurement
Room: Mathematical Institute, L1

Speaker 4 of 6
Peter A. Robbins, University of Oxford, UK
In-Airway Molecular Flow Sensing Using
Laser Absorption Spectroscopy: What Is It and Why Is It Useful?


Wednesday, April 11 | 2:00PM - 4:30PM
Workshop 1: New Techniques for Oxygen Measurement
Room: Mathematical Institute, L1

Speaker 5 of 6
Andrew D. Farmery, University of Oxford, UK
Polymer Fibre-Optic Oxygen Sensors

Wednesday, April 11 | 2:00PM - 4:30PM
Workshop 1: New Techniques for Oxygen Measurement
Room: Mathematical Institute, L1

Speaker 6 of 6
Margaret Ashcroft, University of Cambridge, UK
CHCHD4 Confers Sensitivity to HIF Pathway Inhibitors

Wednesday, April 11 | 4:30PM - 5:00PM
Coffee Available
Room: South Mezzanine


Wednesday, April 11 | 5:00PM - 7:00PM
Hypoxia and Organ (dys)Function
Room: Mathematical Institute, L1

Speaker 1 of 5
* Peppi Koivunen, University of Oulu, Finland

Wednesday, April 11 | 5:00PM - 7:00PM
Hypoxia and Organ (dys)Function
Room: Mathematical Institute, L1

Speaker 2 of 5
Johanna Myllyharju, University of Oulu, Finland
Transmembrane Prolyl 4-Hydroxylase (P4H-TM/PHD4) – Further Light into the Roles of this Enigmatic Enzyme

Wednesday, April 11 | 5:00PM - 7:00PM
Hypoxia and Organ (dys)Function
Room: Mathematical Institute, L1

Speaker 3 of 5
Dörthe M. Katschinski, Georg August University, Germany
The HIF-PHD Pathway in the Cardiovascular System

Wednesday, April 11 | 5:00PM - 7:00PM
Hypoxia and Organ (dys)Function
Room: Mathematical Institute, L1

Speaker 4 of 5
Volker H. Haase, Vanderbilt University, USA
Oxygen Sensing in the Kidney

Wednesday, April 11 | 5:00PM - 7:00PM
Hypoxia and Organ (dys)Function
Room: Mathematical Institute, L1

Speaker 5 of 5
Joanne Holliday, University of Nottingham, UK
Short Talk: Ablation of Factor Inhibiting HIF (FIH1) Modulates Cardiac Function and Improves Hypoxic Tolerance

Wednesday, April 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: South Mezzanine
No registration fees are used to fund alcohol served at this function.

Wednesday, April 11 | 7:30PM - 10:00PM
Poster Session 1
Room: South Mezzanine


Thursday, April 12 | 8:30AM - 11:45AM
Hypoxia and Development
Room: Mathematical Institute, L1

Speaker 1 of 8
* Cormac Taylor, University College Dublin, Ireland

Thursday, April 12 | 8:30AM - 11:45AM
Hypoxia and Development
Room: Mathematical Institute, L1

Speaker 2 of 8
Dino A. Giussani, University of Cambridge, UK
Heart Disease Link to Fetal Hypoxia: An Intergenerational Perspective

Thursday, April 12 | 8:30AM - 11:45AM
Hypoxia and Development
Room: Mathematical Institute, L1

Speaker 3 of 8
Josh Bonkowsky, University of Utah, USA
Hypoxia and Connectivity in the Developing Vertebrate Nervous System

Thursday, April 12 | 8:30AM - 11:45AM
Hypoxia and Development
Room: Mathematical Institute, L1


Coffee Break

Thursday, April 12 | 8:30AM - 11:45AM
Hypoxia and Development
Room: Mathematical Institute, L1

Speaker 5 of 8
Ernestina Schipani, University of Michigan, USA
Impairment of Mitochondrial Respiration Promotes Survival of HIF-1alpha Deficient Chondrocytes in vivo

Thursday, April 12 | 8:30AM - 11:45AM
Hypoxia and Development
Room: Mathematical Institute, L1

Speaker 6 of 8
Pablo Wappner, Fundacion Instituto Leloir, Argentina
Novel Mechanisms of HIF Regulation: Genetic Lessons from Drosophila

Thursday, April 12 | 8:30AM - 11:45AM
Hypoxia and Development
Room: Mathematical Institute, L1

Speaker 7 of 8
Emma U. Hammarlund, Lund University, Sweden
Short Talk: Pseudohypoxia-Activated Pathways Were Essential for Vertebrate Evolution in Earth's Oxic Niche

Thursday, April 12 | 8:30AM - 11:45AM
Hypoxia and Development
Room: Mathematical Institute, L1

Speaker 8 of 8
Tiffany M. Bernardo, University of Pittsburgh, USA
Short Talk: Hypoxia, PPAR?, and Lactate Metabolism in Placental Development and Injury

Thursday, April 12 | 11:45AM - 5:00PM
On Own for Lunch


Thursday, April 12 | 11:45AM - 1:00PM
Poster Setup
Room: South Mezzanine


Thursday, April 12 | 1:00PM - 10:00PM
Poster Viewing
Room: South Mezzanine


Thursday, April 12 | 4:30PM - 5:00PM
Coffee Available
Room: South Mezzanine


Thursday, April 12 | 5:00PM - 7:00PM
Clinical Inhibitors of HIF Hydroxylases and HIFs
Room: Mathematical Institute, L1

Speaker 1 of 6
* Sarah R. Walmsley, University of Edinburgh, Queen's Medical Research Institute, UK

Thursday, April 12 | 5:00PM - 7:00PM
Clinical Inhibitors of HIF Hydroxylases and HIFs
Room: Mathematical Institute, L1

Speaker 2 of 6
Martin Richard Späth, University Hospital of Cologne, Germany
Short Talk: Molecular Correlates of Hypoxic Preconditioning and PHD-Inhibition in Renal Ischemia Reperfusion Injury

Thursday, April 12 | 5:00PM - 7:00PM
Clinical Inhibitors of HIF Hydroxylases and HIFs
Room: Mathematical Institute, L1

Speaker 3 of 6
Christopher J. Schofield, University of Oxford, UK
Inhibiting 2-Oxogluterate Oxygenases for Therapeutic Benefit

Thursday, April 12 | 5:00PM - 7:00PM
Clinical Inhibitors of HIF Hydroxylases and HIFs
Room: Mathematical Institute, L1

Speaker 4 of 6
Chris W. Pugh, University of Oxford, UK
Inducible Phd2 Knockdown in the Mouse Reveals Immunological Effects that Warrant Consideration in the Context of Pharmacological Inhibition of this Enzyme in the Clinic

Thursday, April 12 | 5:00PM - 7:00PM
Clinical Inhibitors of HIF Hydroxylases and HIFs
Room: Mathematical Institute, L1

Speaker 5 of 6
Kyoji Yamaguchi, Vanderbilt University Medical Center, USA
Short Talk: DS-1093a, A Novel HIF Prolyl Hydroxylase Inhibitor, Has Therapeutic Potential in a Wide Range of Diseases

Thursday, April 12 | 5:00PM - 7:00PM
Clinical Inhibitors of HIF Hydroxylases and HIFs
Room: Mathematical Institute, L1

Speaker 6 of 6
Thomas Kietzmann, University of Oulu, Finland
Short Talk: The Epidermal Growth Factor Receptor (EGFR) Adaptor Protein CIN85 Is a Novel Inhibitory Binding Partner of
Hypoxia-Inducible Factor Prolyl Hydroxylase 2 (PHD2)


Thursday, April 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: South Mezzanine
No registration fees are used to fund alcohol served at this function.

Thursday, April 12 | 7:30PM - 10:00PM
Poster Session 2
Room: South Mezzanine


Friday, April 13 | 8:30AM - 11:30AM
Immune and Inflammatory Effects of Hypoxia
Room: Mathematical Institute, L1

Speaker 1 of 7
* Edurne Berra, CIC bioGUNE, Spain

Friday, April 13 | 8:30AM - 11:30AM
Immune and Inflammatory Effects of Hypoxia
Room: Mathematical Institute, L1

Speaker 2 of 7
Moira K. Whyte, University of Edinburgh, Queen's Medical Research Institute, UK
Hypoxia and Regulation of Inflammatory Cell Migration

Friday, April 13 | 8:30AM - 11:30AM
Immune and Inflammatory Effects of Hypoxia
Room: Mathematical Institute, L1

Speaker 3 of 7
Yun-Cai Liu, La Jolla Institute for Allergy and Immunology, USA
VHL-HIF-Glycolytic Pathway in Immune Regulation

Friday, April 13 | 8:30AM - 11:30AM
Immune and Inflammatory Effects of Hypoxia
Room: Mathematical Institute, L1


Coffee Break

Friday, April 13 | 8:30AM - 11:30AM
Immune and Inflammatory Effects of Hypoxia
Room: Mathematical Institute, L1

Speaker 5 of 7
Sarah R. Walmsley, University of Edinburgh, Queen's Medical Research Institute, UK
Hypoxia and Regulation of Inflammation and Anti-Microbial Responses

Friday, April 13 | 8:30AM - 11:30AM
Immune and Inflammatory Effects of Hypoxia
Room: Mathematical Institute, L1

Speaker 6 of 7
Randall S. Johnson, University of Cambridge, UK
Hypoxia and its Role in the Interaction of the Innate and Adaptive Immune Systems

Friday, April 13 | 8:30AM - 11:30AM
Immune and Inflammatory Effects of Hypoxia
Room: Mathematical Institute, L1

Speaker 7 of 7
Einav Gross, Hebrew University of Jerusalem, Israel
Short Talk: Innate Immunity Regulation by Neuronal Oxygen Sensors in the Nematode Caenorhabditis elegans

Friday, April 13 | 11:30AM - 5:00PM
On Own for Lunch


Friday, April 13 | 11:30AM - 1:00PM
Poster Setup
Room: South Mezzanine


Friday, April 13 | 1:00PM - 10:00PM
Poster Viewing
Room: South Mezzanine


Friday, April 13 | 2:30PM - 4:30PM
Workshop 2: Chromatin and Epigenetics
Room: Mathematical Institute, L1

Speaker 1 of 7
* Moira K. Whyte, University of Edinburgh, Queen's Medical Research Institute, UK

Friday, April 13 | 2:30PM - 4:30PM
Workshop 2: Chromatin and Epigenetics
Room: Mathematical Institute, L1

Speaker 2 of 7
Sophie Cowman, University of Liverpool, UK
Alteration of DNA Repair Activity in Hypoxic Brain Tumours Underlies Treatment Resistance

Friday, April 13 | 2:30PM - 4:30PM
Workshop 2: Chromatin and Epigenetics
Room: Mathematical Institute, L1

Speaker 3 of 7
Minoru Kobayashi, Kyoto University, Japan
A Circadian Clock Gene, PER2, Activates HIF-1 as an Effector Molecule for Recruitment of HIF-1a to Promoter Regions of its Downstream Genes

Friday, April 13 | 2:30PM - 4:30PM
Workshop 2: Chromatin and Epigenetics
Room: Mathematical Institute, L1

Speaker 4 of 7
Tamas Ordog, Mayo Clinic, USA
Hypoxia-Inducible Factor 1 alpha (HIF1A) Stimulates Neuronal Nitric Oxide Synthase (Nos1) Transcription by Modifying Spatial Chromatin Organization

Friday, April 13 | 2:30PM - 4:30PM
Workshop 2: Chromatin and Epigenetics
Room: Mathematical Institute, L1

Speaker 5 of 7
Ilaria Maria Cristina Orlando, University of Fribourg, Switzerland
Regulatory DNA Elements Modulating Oxygen-Regulated Erythropoietin Gene Expression

Friday, April 13 | 2:30PM - 4:30PM
Workshop 2: Chromatin and Epigenetics
Room: Mathematical Institute, L1

Speaker 6 of 7
Catherine Turgeon, Université Laval, Canada
PRMT1-Mediated DOCK6 Arginine Methylation Represses Hypoxia-Inducible Factor-1 (HIF-1) Expression

Friday, April 13 | 2:30PM - 4:30PM
Workshop 2: Chromatin and Epigenetics
Room: Mathematical Institute, L1

Speaker 7 of 7
Michael Batie, University of Liverpool, UK
The Role of Chromatin Structure and JmjC Histone Demethylases in the Hypoxic Response

Friday, April 13 | 4:30PM - 5:00PM
Coffee Available
Room: South Mezzanine


Friday, April 13 | 5:00PM - 7:00PM
Hypoxia and Stem Cell Function
Room: Mathematical Institute, L1

Speaker 1 of 5
* Pablo Wappner, Fundacion Instituto Leloir, Argentina

Friday, April 13 | 5:00PM - 7:00PM
Hypoxia and Stem Cell Function
Room: Mathematical Institute, L1

Speaker 2 of 5
Kamil R. Kranc, Barts Cancer Institute, Queen Mary University of London, UK
Hypoxia Signaling in Normal and Malignant Haematopoiesis

Friday, April 13 | 5:00PM - 7:00PM
Hypoxia and Stem Cell Function
Room: Mathematical Institute, L1

Speaker 3 of 5
Paul R. Riley, University of Oxford, UK
The Role of Hypoxia and HIF-Signaling in Epicardial Activation during Neonatal Cardiac Regeneration

Friday, April 13 | 5:00PM - 7:00PM
Hypoxia and Stem Cell Function
Room: Mathematical Institute, L1

Speaker 4 of 5
Edurne Berra, CIC bioGUNE, Spain
Harnessing the Intricate Crosstalk in Hypoxia Signaling Pathways

Friday, April 13 | 5:00PM - 7:00PM
Hypoxia and Stem Cell Function
Room: Mathematical Institute, L1

Speaker 5 of 5
Jong Park, University of Maryland, Baltimore County, USA
Short Talk: Role of Lactate-NDRG1 Signaling in Low Oxygen Tolerance

Friday, April 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: South Mezzanine
No registration fees are used to fund alcohol served at this function.

Friday, April 13 | 7:30PM - 10:00PM
Poster Session 3
Room: South Mezzanine


Saturday, April 14 | 8:30AM - 11:30AM
Tissue Degeneration, Regeneration and Programming
Room: Mathematical Institute, L1

Speaker 1 of 7
* Johanna Myllyharju, University of Oulu, Finland

Saturday, April 14 | 8:30AM - 11:30AM
Tissue Degeneration, Regeneration and Programming
Room: Mathematical Institute, L1

Speaker 2 of 7
Peppi Koivunen, University of Oulu, Finland
HIF Prolyl 4-Hydroxylase Inhibition in Fatty Liver Diseases

Saturday, April 14 | 8:30AM - 11:30AM
Tissue Degeneration, Regeneration and Programming
Room: Mathematical Institute, L1

Speaker 3 of 7
Sean P. Colgan, University of Colorado Denver, USA
Hypoxia and HIF as Regulators of Barrier Function in the Mucosa

Saturday, April 14 | 8:30AM - 11:30AM
Tissue Degeneration, Regeneration and Programming
Room: Mathematical Institute, L1


Coffee Break

Saturday, April 14 | 8:30AM - 11:30AM
Tissue Degeneration, Regeneration and Programming
Room: Mathematical Institute, L1

Speaker 5 of 7
Hesham A. Sadek, University of Texas Southwestern Medical Center, USA
Redox Regulation of Cardiomyocyte Renewal

Saturday, April 14 | 8:30AM - 11:30AM
Tissue Degeneration, Regeneration and Programming
Room: Mathematical Institute, L1

Speaker 6 of 7
Tracey A. Rouault, NICHD, National Institutes of Health, USA
Translational Regulation of HIF2 alpha and Erythropoiesis by the IRE-IRP System

Saturday, April 14 | 8:30AM - 11:30AM
Tissue Degeneration, Regeneration and Programming
Room: Mathematical Institute, L1

Speaker 7 of 7
James A. Nathan, Cambridge Institute for Medical Research, UK
Short Talk: The Endolysosomal Vacuolar-ATPase Complex Controls HIF Signaling by Restricting Iron Availability

Saturday, April 14 | 11:30AM - 12:30PM
Keynote Address
Room: Mathematical Institute, L1

Speaker 1 of 5
* Chris W. Pugh, University of Oxford, UK

Saturday, April 14 | 11:30AM - 12:30PM
Keynote Address
Room: Mathematical Institute, L1

Speaker 2 of 5
* Pablo Wappner, Fundacion Instituto Leloir, Argentina

Saturday, April 14 | 11:30AM - 12:30PM
Keynote Address
Room: Mathematical Institute, L1

Speaker 3 of 5
* Johanna Myllyharju, University of Oulu, Finland

Saturday, April 14 | 11:30AM - 12:30PM
Keynote Address
Room: Mathematical Institute, L1

Speaker 4 of 5
* Moira K. Whyte, University of Edinburgh, Queen's Medical Research Institute, UK

Saturday, April 14 | 11:30AM - 12:30PM
Keynote Address
Room: Mathematical Institute, L1

Speaker 5 of 5
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Do Histone Demethylases Directly Sense Oxygen to Control Chromatin Structure and Cell Fate?

Saturday, April 14 | 12:30PM - 5:00PM
On Own for Lunch


Saturday, April 14 | 2:30PM - 4:30PM
Workshop 3: Physiology and Metabolism
Room: Mathematical Institute, L1

Speaker 1 of 7
* Thomas Kietzmann, University of Oulu, Finland

Saturday, April 14 | 2:30PM - 4:30PM
Workshop 3: Physiology and Metabolism
Room: Mathematical Institute, L1

Speaker 2 of 7
Penny Anne Gowland, University of Nottingham, UK
Assessing Oxygenation in vivo with MR

Saturday, April 14 | 2:30PM - 4:30PM
Workshop 3: Physiology and Metabolism
Room: Mathematical Institute, L1

Speaker 3 of 7
Franziska Dengler, University of Leipzig, Germany
Hypoxia in Jejunum Epithelium: Fast Adaptation of Glucose Transport

Saturday, April 14 | 2:30PM - 4:30PM
Workshop 3: Physiology and Metabolism
Room: Mathematical Institute, L1

Speaker 4 of 7
Paul Grevitt, Barts Cancer Institute, UK
Identification of Novel Regulators of HIFs

Saturday, April 14 | 2:30PM - 4:30PM
Workshop 3: Physiology and Metabolism
Room: Mathematical Institute, L1

Speaker 5 of 7
Amalia Ruiz-Serrano, University of Zürich, Switzerland
Deletion of the FIH Substrate OTUB1 in Mice Affects Viability, Energy Metabolism and Oxygen Physiology

Saturday, April 14 | 2:30PM - 4:30PM
Workshop 3: Physiology and Metabolism
Room: Mathematical Institute, L1

Speaker 6 of 7
Julián Aragonés Lopez, Research Institute Princesa, Spain
Role of Hif2a-Epo Pathway in Airway Response to Oxygen FluctuatioNS

Saturday, April 14 | 2:30PM - 4:30PM
Workshop 3: Physiology and Metabolism
Room: Mathematical Institute, L1

Speaker 7 of 7
Gijsbert Jacob van Belle, Universitätsmedizin Göttingen, Germany
Hypoxia-Stimulated Membrane Trafficking Requires T-Plastin

Saturday, April 14 | 4:30PM - 5:00PM
Coffee Available
Room: South Mezzanine


Saturday, April 14 | 5:00PM - 6:45PM
Epigenetic and Pan-Genomic Effects of Hypoxia
Room: Mathematical Institute, L1

Speaker 1 of 4
* Chris W. Pugh, University of Oxford, UK

Saturday, April 14 | 5:00PM - 6:45PM
Epigenetic and Pan-Genomic Effects of Hypoxia
Room: Mathematical Institute, L1

Speaker 2 of 4
Raul Mostoslavsky, Harvard Medical School, USA
Linking Epigenetics, Metabolism and Cancer: Lessons from SIRT6

Saturday, April 14 | 5:00PM - 6:45PM
Epigenetic and Pan-Genomic Effects of Hypoxia
Room: Mathematical Institute, L1

Speaker 3 of 4
Skirmantas Kriaucionis, University of Oxford, UK
TET Proteins and 5-Hydroxymethylcytosine in Transcription

Saturday, April 14 | 5:00PM - 6:45PM
Epigenetic and Pan-Genomic Effects of Hypoxia
Room: Mathematical Institute, L1

Speaker 4 of 4
Joaquín M. Espinosa, Linda Crnic Institute for Down Syndrome, USA
Mechanisms of Transcriptional Regulation during the Hypoxic Response

Saturday, April 14 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Mathematical Institute, L1


Saturday, April 14 | 7:00PM - 8:30PM
Social Hour with Lite Bites
Room: South Mezzanine
No registration fees are used to fund alcohol served at this function.

Sunday, April 15 | 10:24AM - 10:24AM
Departure


*Session Chair.