Web Desc
Immunological Memory: Innate, Adaptive and Beyond
joint with Aging, Inflammation and Immunity
Organizer(s): Rafi Ahmed, Susan M. Kaech and Joseph C. Sun
Date: February 25 - March 01, 2018
Location: Hyatt Regency Austin, Austin, TX, USA
Sponsored by AbbVie Inc. and EMD Serono Research and Development Institute, Inc.
Summary of Meeting:
This symposium will primarily focus on integrating current knowledge concerning the cellular and molecular regulation of memory T and B cell responses with their role mediating protection against infections. In addition to the significant impact these cell populations have on vaccination, emphasis will be placed on their therapeutic and pathogenic roles in cancer, autoimmunity and chronic infection. The innate immune response has a profound influence on the regulation of effector and memory T and B cell responses, and recent discoveries in this area bring forth a greater understanding of the major signals that govern both the formation and the long-term maintenance of these populations. These conceptual advancements will be a major part of the symposium. More recently, it has become clear that there is marked phenotypic and functional heterogeneity of T cell responses; how this affects immunological protection will be discussed. Finally, this symposium will include discussion of recent advances in assessing memory T and B cell responses in a sensitive manner in human and non-human primates, as well as murine systems, to enable better elucidation of the state of the immune response during infection and vaccination, which will lead to more rationale vaccine design.
Scholarship Deadline: October 26 2017
Discounted Abstract Deadline: October 26 2017
Abstract Deadline: November 29 2017
Discounted Registration Deadline: December 21 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AbbVie Inc.EMD Serono Research and Development Institute, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline Vaccines
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI136480-01
Funding for this conference was made possible (in part) by 1 R13 AI136480-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 25 | 4:00PM - 8:00PM
Arrival and Registration
Room: Zilker North Lobby


Sunday, February 25 | 6:00PM - 8:00PM
Welcome Mixer
Room: Zilker North Lobby
No registration fees are used to fund alcohol served at this function.

Monday, February 26 | 7:30AM - 8:30AM
Breakfast
Room: Texas Ballroom


Monday, February 26 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Zilker Ballroom

Speaker 1 of 5
* Rafi Ahmed, Emory University School of Medicine, USA

Monday, February 26 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Zilker Ballroom

Speaker 2 of 5
* Bonnie B. Blomberg, University of Miami School of Medicine, USA

Monday, February 26 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Zilker Ballroom

Speaker 3 of 5
Rino Rappuoli, GlaxoSmithKline Vaccines, Italy
Vaccines 2018

Monday, February 26 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Zilker Ballroom

Speaker 4 of 5
Vishwa Deep Dixit, Yale University, USA
Immunometabolic Regulation of Healthspan

Monday, February 26 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Zilker Ballroom


Coffee Break

Monday, February 26 | 10:30AM - 12:45PM
Initial Reactions: Forming Innate Memory
Room: Zilker 1-2

Speaker 1 of 6
* Steven L. Reiner, Columbia University, USA

Monday, February 26 | 10:30AM - 12:45PM
Initial Reactions: Forming Innate Memory
Room: Zilker 1-2

Speaker 2 of 6
Lewis L. Lanier, University of California, San Francisco, USA
NK Cells Remember

Monday, February 26 | 10:30AM - 12:45PM
Initial Reactions: Forming Innate Memory
Room: Zilker 1-2

Speaker 3 of 6
Joseph C. Sun, Memorial Sloan Kettering Cancer Center, USA
Immunological Memory in Innate Lymphocytes

Monday, February 26 | 10:30AM - 12:45PM
Initial Reactions: Forming Innate Memory
Room: Zilker 1-2

Speaker 4 of 6
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Homeostatic Immunity to the Microbiota

Monday, February 26 | 10:30AM - 12:45PM
Initial Reactions: Forming Innate Memory
Room: Zilker 1-2

Speaker 5 of 6
Fadi G. Lakkis, University of Pittsburgh, USA
Short Talk: Specific Monocyte Memory to Allogeneic MHC Mediated by Paired Immunoglobulin Receptors (PIR)

Monday, February 26 | 10:30AM - 12:45PM
Initial Reactions: Forming Innate Memory
Room: Zilker 1-2

Speaker 6 of 6
Samantha B. Larsen, NYU Langone, USA
Short Talk: Inflammatory Memory Sensitizes Skin Epithelial Stem Cells to Tissue Damage

Monday, February 26 | 10:30AM - 12:45PM
Lifestyle, Epigenetics, Interventions
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 1 of 6
* Vishwa Deep Dixit, Yale University, USA


Monday, February 26 | 10:30AM - 12:45PM
Lifestyle, Epigenetics, Interventions
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 2 of 6
Nir Barzilai, Albert Einstein College of Medicine, USA
Moving to Translational Geroscience


Monday, February 26 | 10:30AM - 12:45PM
Lifestyle, Epigenetics, Interventions
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 3 of 6
Manel Esteller, Josep Carreras Leukaemia Research Institute, Spain
Cancer Epigenetics: From Knowledge to Applications


Monday, February 26 | 10:30AM - 12:45PM
Lifestyle, Epigenetics, Interventions
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 4 of 6
Valter D. Longo, University of Southern California, USA
Dietary Interventions


Monday, February 26 | 10:30AM - 12:45PM
Lifestyle, Epigenetics, Interventions
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 5 of 6
Duygu Ucar, The Jackson Laboratory, USA
Short Talk: The Chromatin Accessibility Signature of Human Immune Aging Stems from CD8+ T Cells


Monday, February 26 | 10:30AM - 12:45PM
Lifestyle, Epigenetics, Interventions
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 6 of 6
Leena Bharath, Boston University, USA
Short Talk: Effects of Metformin on Aging-Related Immune Cell Dysfunction


Monday, February 26 | 12:45PM - 5:00PM
On Own for Lunch


Monday, February 26 | 12:45PM - 1:00PM
Poster Setup
Room: Texas Ballroom


Monday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Texas Ballroom


Monday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Zilker North Lobby


Monday, February 26 | 5:00PM - 7:15PM
CD8 T Cell Memory
Room: Zilker 1-2

Speaker 1 of 6
* Rafi Ahmed, Emory University School of Medicine, USA

Monday, February 26 | 5:00PM - 7:15PM
CD8 T Cell Memory
Room: Zilker 1-2

Speaker 2 of 6
Ananda W. Goldrath, University of California, San Diego, USA
Identification of Molecules Essential for CD8+ T Cell Residency in Non-Lymphoid Tissues and Tumors

Monday, February 26 | 5:00PM - 7:15PM
CD8 T Cell Memory
Room: Zilker 1-2

Speaker 3 of 6
Dirk Hans Busch, Technical University Munich, Germany
Lineage Tracing of Memory CD8 T Cell Development

Monday, February 26 | 5:00PM - 7:15PM
CD8 T Cell Memory
Room: Zilker 1-2

Speaker 4 of 6
Steven L. Reiner, Columbia University, USA
Metabolic Ambivalence and the Logic of Immunologic Memory

Monday, February 26 | 5:00PM - 7:15PM
CD8 T Cell Memory
Room: Zilker 1-2

Speaker 5 of 6
Scott N. Mueller, University of Melbourne, Australia
Short Talk: Lymphoid Stromal Cells Support CD8 T Cell Priming and Memory

Monday, February 26 | 5:00PM - 7:15PM
CD8 T Cell Memory
Room: Zilker 1-2

Speaker 6 of 6
Henrique Borges da Silva, University of Minnesota, USA
Short Talk: The Extracellular ATP Receptor P2RX7 Controls Metabolic Fitness of Long-Lived Memory CD8+ T Cells

Monday, February 26 | 5:00PM - 7:00PM
Longitudinal Studies on Aging and Immunity
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 1 of 5
* Daniela Frasca, University of Miami, USA


Monday, February 26 | 5:00PM - 7:00PM
Longitudinal Studies on Aging and Immunity
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 2 of 5
Graham Pawelec, University of Tübingen, Germany
Immune Parameters Associated with Mortality in the Elderly Are Context-Dependent: Lessons from Sweden, Holland and Belgium


Monday, February 26 | 5:00PM - 7:00PM
Longitudinal Studies on Aging and Immunity
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 3 of 5
Luigi Ferrucci, NIA, National Institutes of Health, USA
Blood Inflammatory Mediators and Aging: Causes and Consequences


Monday, February 26 | 5:00PM - 7:00PM
Longitudinal Studies on Aging and Immunity
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 4 of 5
Allison E. Aiello, University of North Carolina at Chapel Hill, USA
Stress, Immunity, Infection and Cellular Aging in Population-Based Studies


Monday, February 26 | 5:00PM - 7:00PM
Longitudinal Studies on Aging and Immunity
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 5 of 5
Rebecca G. Reed, University of Kentucky, USA
Short Talk: Stress, Cytomegalovirus, and Immunosenescence: A Longitudinal Study of Older Adults


Monday, February 26 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Texas Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, February 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Texas Ballroom


Tuesday, February 27 | 7:30AM - 8:30AM
Breakfast
Room: Texas Ballroom


Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
Room: Zilker 1-2

Speaker 1 of 8
* Marion Pepper, University of Washington, USA

Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
Room: Zilker 1-2

Speaker 2 of 8
Shane Crotty, La Jolla Institute for Immunology, USA
T Follicular Helper (Tfh) CD4 T Cells, Germinal Centers and the Generation of Memory

Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
Room: Zilker 1-2

Speaker 3 of 8
Marc K. Jenkins, University of Minnesota Medical School, USA
Differentiation of CD4+ T Effector and Memory Cells during Bacterial Infection

Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
Room: Zilker 1-2


Coffee Break

Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
Room: Zilker 1-2

Speaker 5 of 8
Mark R. Boothby, Vanderbilt University Medical Center, USA
Hypoxia-Inducible Factors Regulate Metabolism and Function of B Cells and their Helpers in Antibody Responses

Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
Room: Zilker 1-2

Speaker 6 of 8
Amy Weinmann, University of Alabama at Birmingham, USA
Role for Metabolites in T Cell Differentiation Programs

Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
Room: Zilker 1-2

Speaker 7 of 8
Lillian B. Cohn, Chan Zuckerberg Biohub, USA
Short Talk: Clonally Expanded CD4+ T Cells Contribute to the HIV-1 Latent Reservoir and Display a Distinct Gene Signature upon Reactivation

Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
Room: Zilker 1-2

Speaker 8 of 8
Raquel Furtado, Albert Einstein College of Medicine, USA
Short Talk: Expansion of Circulating CXCR3loPD-1+CXCR5+ Memory CD4+ T Helper Cells Correlates with Clinical Protection against Human Malaria

Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 1 of 8
* Janet M. Lord, University of Birmingham, UK


Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 2 of 8
Judith Campisi, Buck Institute for Research on Aging, USA
Cellular Senescence and Inflammaging


Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 3 of 8
Margaret M. Harnett, University of Glasgow, UK
Short Talk: Can the Parasitic Worm Product ES-62 Protect against Diet-Associated Pathologies in Aging Male and Female Mice?


Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 4 of 8
Debbie Van Baarle, National Institute of Public Health and Environment, Netherlands
Short Talk: Proinflammatory Microbial Profiles Associate with Respiratory Infections in Older Adults


Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
This session is from Aging and Inflammation
Room: Zilker 3-4


Coffee Break


Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 6 of 8
Daniela Frasca, University of Miami, USA
Adipose Tissue, Inflammation and Aging


Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 7 of 8
Michael P. Cancro, University of Pennsylvania, USA
Mechanisms that Regulate Age-Associated B Cell Formation and Survival


Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 8 of 8
Elizabeth A. Leadbetter, University of Texas Long School of Medicine, USA
Short Talk: iNKT Cells Support Tbet+ B Cells in Adipose Tissue and Are Required to Limit Symptoms of Metabolic Disease


Tuesday, February 27 | 11:45AM - 5:00PM
On Own for Lunch


Tuesday, February 27 | 11:45AM - 1:00PM
Poster Setup
Room: Texas Ballroom


Tuesday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Texas Ballroom


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
Room: Zilker 1-2

Speaker 1 of 7
* Joseph C. Sun, Memorial Sloan Kettering Cancer Center, USA

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
Room: Zilker 1-2

Speaker 2 of 7
Brian J. Laidlaw, University of California, San Francisco, USA
The Eph-Related Tyrosine Kinase Ligand Ephrin-B1 Marks Germinal Center and Memory Precursor B Cells

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
Room: Zilker 1-2

Speaker 3 of 7
Anoma Nellore, University of Alabama at Birmingham, USA
T-bet Expression by Influenza-Specific Human Memory B Cells Is Differentially Regulated by Vaccine Platform and Prior Host Immunity and Correlates with Long-Lived Antibody Responses

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
Room: Zilker 1-2

Speaker 4 of 7
Aakanksha Jain, UT Southwestern Medical Center, USA
T Cell Intrinsic IL-1R Signaling Licenses Effector Cytokine Production by Memory CD4 T Cells

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
Room: Zilker 1-2

Speaker 5 of 7
Robin Stephens, University of Texas Medical Branch, USA
Mechanisms of Maintenance of Protection from Persistent Malaria Infection by CD4 Effector Memory T Cells

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
Room: Zilker 1-2

Speaker 6 of 7
Thomas Ciucci, NCI, National Institutes of Health, USA
The Development of Memory CD4 T Cells Relies on a Thpok-Dependent Circuitry-Antagonizing Exhaustion Program

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
Room: Zilker 1-2

Speaker 7 of 7
Ning Jenny Jiang, University of Texas at Austin, USA
High-Throughput Single-Cell Linking of Antigen Specificities with T Cell Receptor Sequences using de novo Generated DNA-Linked MHC Tetramers

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 1 of 9
* Bonnie B. Blomberg, University of Miami School of Medicine, USA


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 2 of 9
Petra Burilova, St. Anne´s University Hospital, Czech Republic
Accelerated Aging of Monocytes in Childhood and Adolescent Cancer Survivors


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 3 of 9
Mati Mann, California Institute of Technology, USA
Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 4 of 9
Nick P. Goplen, Mayo Clinic, USA
Non-Resolving Influenza Response in Geriatric Lungs


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 5 of 9
Kylie Quinn, Monash University, Australia
Survival of Naïve CD8 T Cells During Aging Is Controlled by Homeostatic Signaling and Metabolic Remodeling


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 6 of 9
Michelle Ratliff, University of Okalhoma Health Sciences Center, USA
Expression of the DNA-Binding Protein ARID3a, a Mediator of Human Hematopoiesis, Is Reduced in Hematopoietic Progenitors from Aged Individuals


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 7 of 9
YanChun Peng, University of Oxford, UK
Identifying Age-Associated Immune Signatures on Influenza-Specific Human Memory T Cells using Single-Cell RNASeq


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 8 of 9
Bo Ruem Yoon, Seoul National University College of Medicine, South Korea
SLC7A5-Mediated Leucine Influx Controls IL-1ß Production via Glycolytic Reprogramming in Human Monocytes/Macrophages


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 9 of 9
Juan I. Moliva, Vaccine Research Center, USA
Natural Aging Is Associated with Decreases in Lung Fluid Innate Immune Protein Function Driving Susceptibility to Mycobacterium Tuberculosis Infection


Tuesday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Zilker North Lobby


Tuesday, February 27 | 5:00PM - 7:15PM
New Ways to Generate B Cell Memory
Room: Zilker 1-2

Speaker 1 of 6
* Shane Crotty, La Jolla Institute for Immunology, USA

Tuesday, February 27 | 5:00PM - 7:15PM
New Ways to Generate B Cell Memory
Room: Zilker 1-2

Speaker 2 of 6
Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Heterogeneity of Memory B Cell Compartments

Tuesday, February 27 | 5:00PM - 7:15PM
New Ways to Generate B Cell Memory
Room: Zilker 1-2

Speaker 3 of 6
David M. Tarlinton, Monash University, Australia
Molecular Regulation of Germinal Center Responses and B Cell Memory

Tuesday, February 27 | 5:00PM - 7:15PM
New Ways to Generate B Cell Memory
Room: Zilker 1-2

Speaker 4 of 6
Scott D. Boyd, Stanford University, USA
B Cell Memory Repertoires in Vaccination and Infection

Tuesday, February 27 | 5:00PM - 7:15PM
New Ways to Generate B Cell Memory
Room: Zilker 1-2

Speaker 5 of 6
Mary F. Fontana, University of Washington, USA
Short Talk: Expansion of an FCRL5+ B Cell Subset Resembling Atypical Memory B Cells in an Animal Model of Malaria

Tuesday, February 27 | 5:00PM - 7:15PM
New Ways to Generate B Cell Memory
Room: Zilker 1-2

Speaker 6 of 6
Ali H. Ellebedy, Washington University School of Medicine, USA
Short Talk: Biphasic B Cell Responses to Adjuvanted H5N1 Influenza Virus Vaccination in Humans

Tuesday, February 27 | 5:00PM - 7:00PM
Frailty, Morbidity, Mortality/Survival
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 1 of 5
* Nir Barzilai, Albert Einstein College of Medicine, USA


Tuesday, February 27 | 5:00PM - 7:00PM
Frailty, Morbidity, Mortality/Survival
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 2 of 5
Janet M. Lord, University of Birmingham, UK
Exercise, Frailty, Inflammation and Aging


Tuesday, February 27 | 5:00PM - 7:00PM
Frailty, Morbidity, Mortality/Survival
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 3 of 5
Janet E. McElhaney, Health Sciences North Research Institute, Canada
Frailty, Inflammation and Immunosenescence


Tuesday, February 27 | 5:00PM - 7:00PM
Frailty, Morbidity, Mortality/Survival
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 4 of 5
Daniel Belsky, Duke University, USA
Quantification of Biological Aging: Implications for Clinical Trials and Extension of Healthspan


Tuesday, February 27 | 5:00PM - 7:00PM
Frailty, Morbidity, Mortality/Survival
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 5 of 5
Leonard Daniël Samson, National Institute for Public Health and the Environment/ RIVM, Netherlands
Short Talk: The Relationship between Frailty, Disease and the Development of Immunosenescence over a Time Span of More
than 20 Years


Tuesday, February 27 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Texas Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, February 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Texas Ballroom


Wednesday, February 28 | 7:30AM - 8:30AM
Breakfast
Room: Texas Ballroom


Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
Room: Zilker 1-2

Speaker 1 of 8
* Ananda W. Goldrath, University of California, San Diego, USA

Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
Room: Zilker 1-2

Speaker 2 of 8
Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Mitochondrial Priming By CD28

Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
Room: Zilker 1-2

Speaker 3 of 8
Ronald N. Germain, NIAID, National Institutes of Health, USA
Using Multiplex Histocytometry to Relate Tissue Microanatomy to Immune Activation and Regulation

Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
Room: Zilker 1-2


Coffee Break

Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
Room: Zilker 1-2

Speaker 5 of 8
Ellen A. Robey, University of California, Berkeley, USA
What Makes a Protective Anti-Toxoplasma T Cell Response?

Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
Room: Zilker 1-2

Speaker 6 of 8
Susan M. Kaech, The Salk Institute, USA
Metabolic Control of Memory T Cell Lifespan

Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
Room: Zilker 1-2

Speaker 7 of 8
John R. Teijaro, The Scripps Research Institute, USA
Short Talk: Cytokine-Mediated Expansion of Follicular Cytotoxic T Cells

Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
Room: Zilker 1-2

Speaker 8 of 8
Kimberly S. Schluns, University of Texas MD Anderson Cancer Center, USA
Short Talk: Upregulating IL-15 in the Tumor Microenvironment Promotes Anti-Tumor Responses

Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 1 of 8
* Judith Campisi, Buck Institute for Research on Aging, USA


Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 2 of 8
* Michael P. Cancro, University of Pennsylvania, USA


Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 3 of 8
Jorg J. Goronzy, Stanford University School of Medicine, USA
MicroRNA Regulation of T Cell Aging


Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 4 of 8
Janko Nikolich-Zugich, University of Arizona College of Medicine, USA
T Cell Rejuvenation Requires Multiple Steps to Restore Immune Function with Aging


Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
This session is from Aging and Inflammation
Room: Zilker 3-4


Coffee Break


Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 6 of 8
Laura Haynes, UConn Health, USA
The Impact of Aging on Response to Influenza Infection


Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 7 of 8
Russell C. Ault, Texas Biomedical Research Institute, USA
Short Talk: Age-Related Differences in Peripheral Immunity at Tuberculosis Diagnosis in Humans


Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 8 of 8
Patricia J. Gearhart, NIA, National Institutes of Health, USA
Short Talk: Role of B Cells in Atherosclerosis


Wednesday, February 28 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, February 28 | 11:45AM - 1:00PM
Poster Setup
Room: Texas Ballroom


Wednesday, February 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Texas Ballroom


Wednesday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Zilker North Lobby


Wednesday, February 28 | 5:00PM - 7:30PM
Inflammation, Biomarkers of the Aging Immune System and Poss
ible Treatments
This session is from Aging and Inflammation

Room: Zilker 3-4

Speaker 1 of 6
* Arne N. Akbar, University College London, UK


Wednesday, February 28 | 5:00PM - 7:30PM
Inflammation, Biomarkers of the Aging Immune System and Poss
ible Treatments
This session is from Aging and Inflammation

Room: Zilker 3-4

Speaker 2 of 6
Bonnie B. Blomberg, University of Miami School of Medicine, USA
B Cells, Inflammation and Aging in Vaccine Response


Wednesday, February 28 | 5:00PM - 7:30PM
Inflammation, Biomarkers of the Aging Immune System and Poss
ible Treatments
This session is from Aging and Inflammation

Room: Zilker 3-4

Speaker 3 of 6
Susan L. Swain, University of Massachusetts Medical School, USA
Optimum Ag Presentation Can Counteract Age-Related Defects in CD4 T Cell Immunity and Lead to Better CD4 T and B Cell Effector and Memory Responses


Wednesday, February 28 | 5:00PM - 7:30PM
Inflammation, Biomarkers of the Aging Immune System and Poss
ible Treatments
This session is from Aging and Inflammation

Room: Zilker 3-4

Speaker 4 of 6
Luca Pangrazzi, University of Innsbruck, Austria
Adaptive Immunity in the Bone Marrow in Old Age


Wednesday, February 28 | 5:00PM - 7:30PM
Inflammation, Biomarkers of the Aging Immune System and Poss
ible Treatments
This session is from Aging and Inflammation

Room: Zilker 3-4

Speaker 5 of 6
Joan Mannick, resTORbio, USA
TORC1 Inhibition as a Potential Immunotherapy to Decrease Infections in the Elderly


Wednesday, February 28 | 5:00PM - 7:30PM
Inflammation, Biomarkers of the Aging Immune System and Poss
ible Treatments
This session is from Aging and Inflammation

Room: Zilker 3-4

Speaker 6 of 6
Suresh Pallikkuth, University of Miami, USA
Short Talk: Frequency and Function of Antigen-Specific Peripheral T Follicular Helper Cells Are Impaired by Basal Immune
Activation and Impact Flu Vaccine Response in Biologic Aging with and without HIV Infection


Wednesday, February 28 | 5:00PM - 7:15PM
Imprinting Memory in Tissues
Room: Zilker 1-2

Speaker 1 of 6
* Linda S. Cauley, University of Connecticut Health Center, USA

Wednesday, February 28 | 5:00PM - 7:15PM
Imprinting Memory in Tissues
Room: Zilker 1-2

Speaker 2 of 6
David B. Masopust, University of Minnesota, USA
Functions of Trm Cells

Wednesday, February 28 | 5:00PM - 7:15PM
Imprinting Memory in Tissues
Room: Zilker 1-2

Speaker 3 of 6
Donna L. Farber, Columbia University Medical Center, USA
Tissue Specialization and Maintenance of Human Memory T Cells

Wednesday, February 28 | 5:00PM - 7:15PM
Imprinting Memory in Tissues
Room: Zilker 1-2

Speaker 4 of 6
Marion Pepper, University of Washington, USA
Pathological Lung Resident Memory Th2 Cells

Wednesday, February 28 | 5:00PM - 7:15PM
Imprinting Memory in Tissues
Room: Zilker 1-2

Speaker 5 of 6
Laura K. Mackay, University of Melbourne, Australia
Short Talk: Local Maintenance of a Proliferating Tissue-Resident Memory T Cell Pool following Antiviral Recall Responses

Wednesday, February 28 | 5:00PM - 7:15PM
Imprinting Memory in Tissues
Room: Zilker 1-2

Speaker 6 of 6
Angela Pizzolla, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Australia
Short Talk: Nasal Tissue-Resident Memory CD8+ T Cells Prevent Pulmonary Influenza A Virus Infection

Wednesday, February 28 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Texas Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, February 28 | 7:30PM - 10:00PM
Poster Session 3
Room: Texas Ballroom


Thursday, March 01 | 7:30AM - 8:30AM
Breakfast
Room: Texas Ballroom


Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 1 of 8
* Donna L. Farber, Columbia University Medical Center, USA

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 2 of 8
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Lessons from the Analysis of the Immune Response to P. falciparum

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 3 of 8
Bali Pulendran, Stanford University School of Medicine, USA
Lessons from Successful Human Vaccines

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom


Coffee Break

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 5 of 8
Tyler J. Curiel, University of Texas Health, USA
Challenges in Successful Immunotherapy of Cancer in Aged Individuals

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 6 of 8
Arne N. Akbar, University College London, UK
Targeting MAP Kinase Signaling to Enhance Immunity during Aging

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 7 of 8
Katherine Kedzierska, University of Melbourne, Australia
Short Talk: Dynamics of CD8+ T Cell Memory Repertoires across Human Life-Span and Tissue Compartments

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 8 of 8
Sara Van Den Berg, National Institute of Public Health and Environment, Netherlands
Short Talk: T Cell Responses to Influenza Infection in Elderly Are Impaired by Latent Cytomegalovirus (CMV) Infection

Thursday, March 01 | 11:45AM - 5:00PM
On Own for Lunch


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
Room: Zilker 1-2

Speaker 1 of 9
* Susan M. Kaech, The Salk Institute, USA

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
Room: Zilker 1-2

Speaker 2 of 9
Allan J. Zajac, University of Alabama, Birmingham, USA
The Production of IL-2 by CD8 T Cells Shapes Their Fate Decisions and Protective Efficacy

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
Room: Zilker 1-2

Speaker 3 of 9
Enrico Lugli, Humanitas Clinical and Research Center, Italy
High-Dimensional Single Cell Analysis of the Tumor CD8+ T Cell Infiltrate Identifies Long-Lived Memory CD8+ T Cells with Enhanced Stemness

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
Room: Zilker 1-2

Speaker 4 of 9
Philip Ansumana Hull, Bristol-Myers Squibb, USA
Metabolic Reprogramming of Human CD8+ Memory T Cells through Loss of SIRT1

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
Room: Zilker 1-2

Speaker 5 of 9
Vandana Kalia, University of Washington and Seattle Children’s Research Institute, USA
Anatomic and Cellular Regulators of Metabolic Remodeling during Effector CTL to Memory Conversion

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
Room: Zilker 1-2

Speaker 6 of 9
Dietmar Herndler-Brandstetter, Medical University of Vienna, Austria
Developmental Plasticity of KLRG1+ Effector CD8+ T Cells Promotes Protective
Immunity


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
Room: Zilker 1-2

Speaker 7 of 9
Paul Richard Dunbar, SQZ Biotech, USA
Pulmonary Monocytes Promote the Establishment of Lung Tissue-Resident CD8 T Cell Memory following Influenza Infection

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
Room: Zilker 1-2

Speaker 8 of 9
Linda S. Cauley, University of Connecticut Health Center, USA
Innate Cytokine Stimulation Plays a Decisive Role in Late Differentiation of Activated CTLs

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
Room: Zilker 1-2

Speaker 9 of 9
Peter Cockerill, University of Birmingham, UK
Immunological Memory in T Cells is Established via T Cell Receptor Signaling which Creates Stably Maintained Active Chromatin Domains at Immune Response Genes

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 1 of 7
* Graham Pawelec, University of Tübingen, Germany


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 2 of 7
Christina Camell, University of Minnesota, USA
NLRP3 Inflammasome Controls Adipose Tissue B Cell Accumulation during Aging


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 3 of 7
Claire Gustafson, Stanford University, USA
Differentiation- and Age-Related MicroRNA Profiling Reveals Two Dimensions of CD8 T Cell Aging


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 4 of 7
Abhijit Kale, Buck Institute for Research on Aging, USA
Elimination of Senescent Cells by Innate Immune System


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 5 of 7
Mladen Jergovic, University of Arizona, USA
Expression of Ly6C Defines a Subpopulation of Naïve CD8 T Cells with a Rapid Effector Function which Is Expanded Under 'non-SPF' Conditions


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 6 of 7
Susan Baldwin, Infectious Disease Research Institute, USA
Adjuvanted H1N1 Vaccines Improve Immune Responses in Young and Aged Mice


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
This session is from Aging and Inflammation
Room: Zilker 3-4

Speaker 7 of 7
Andy Schile, The Jackson Laboratory, USA
Lessons Learned From Managing Aged Colonies of C57BL/6J Mice


Thursday, March 01 | 4:30PM - 5:00PM
Coffee Available
Room: Zilker North Lobby


Thursday, March 01 | 5:00PM - 6:00PM
The Wear and Tear on T Cells in Chronic Infection and Tumors
Room: Zilker 1-2

Speaker 1 of 3
* Susan M. Kaech, The Salk Institute, USA

Thursday, March 01 | 5:00PM - 6:00PM
The Wear and Tear on T Cells in Chronic Infection and Tumors
Room: Zilker 1-2

Speaker 2 of 3
E. John Wherry, University of Pennsylvania, USA
T Cell Exhaustion

Thursday, March 01 | 5:00PM - 6:00PM
The Wear and Tear on T Cells in Chronic Infection and Tumors
Room: Zilker 1-2

Speaker 3 of 3
Rafi Ahmed, Emory University School of Medicine, USA
Human CD8 T Cell Memory

Thursday, March 01 | 5:00PM - 6:15PM
Genetic, Epigenetic, Transcriptomic Regulation of Aging and
Age-Related Diseases
This session is from Aging and Inflammation

Room: Zilker 3-4

Speaker 1 of 4
* Bonnie B. Blomberg, University of Miami School of Medicine, USA


Thursday, March 01 | 5:00PM - 6:15PM
Genetic, Epigenetic, Transcriptomic Regulation of Aging and
Age-Related Diseases
This session is from Aging and Inflammation

Room: Zilker 3-4

Speaker 2 of 4
* Graham Pawelec, University of Tübingen, Germany


Thursday, March 01 | 5:00PM - 6:15PM
Genetic, Epigenetic, Transcriptomic Regulation of Aging and
Age-Related Diseases
This session is from Aging and Inflammation

Room: Zilker 3-4

Speaker 3 of 4
Albert C. Shaw, Yale School of Medicine, USA
Consequences of Aging on Signatures of Influenza Vaccine Response


Thursday, March 01 | 5:00PM - 6:15PM
Genetic, Epigenetic, Transcriptomic Regulation of Aging and
Age-Related Diseases
This session is from Aging and Inflammation

Room: Zilker 3-4

Speaker 4 of 4
Ruth R. Montgomery, Yale University School of Medicine, USA
Short Talk: Expression and Signaling of TAM Receptor Inflammatory Regulators in Aging


Thursday, March 01 | 6:00PM - 6:45PM
Closing Keynote Address
Room: Zilker 1-2

Speaker 1 of 2
* Susan M. Kaech, The Salk Institute, USA

Thursday, March 01 | 6:00PM - 6:45PM
Closing Keynote Address
Room: Zilker 1-2

Speaker 2 of 2
Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Human Memory T Cell Subsets: from Phenotype to Function

Thursday, March 01 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Zilker 1-2


Thursday, March 01 | 7:00PM - 7:15PM
Discussion of Meeting, Summary, Conclusion and Mouse-Human C
onnections
This session is from Aging and Inflammation

Room: Zilker 3-4

Speaker 1 of 2
* Bonnie B. Blomberg, University of Miami School of Medicine, USA


Thursday, March 01 | 7:00PM - 7:15PM
Discussion of Meeting, Summary, Conclusion and Mouse-Human C
onnections
This session is from Aging and Inflammation

Room: Zilker 3-4

Speaker 2 of 2
* Graham Pawelec, University of Tübingen, Germany


Thursday, March 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Texas Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, March 01 | 8:00PM - 11:00PM
Entertainment
Room: Texas Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 01 | 8:00PM - 11:00PM
Cash Bar
Room: Texas Ballroom


Friday, March 02 | 10:24AM - 10:24AM
Departure


*Session Chair.