Web Desc
Aging, Inflammation and Immunity
joint with Immunological Memory: Innate, Adaptive and Beyond
Organizer(s): Bonnie B. Blomberg and Graham Pawelec
Date: February 25 - March 01, 2018
Location: Hyatt Regency Austin, Austin, TX, USA
This activity was supported by an educational grant from Celgene Corporation
For important information on the coronavirus, please click here
Summary of Meeting:
The world’s aging population and problems with morbidity have been increasing rapidly. Decreases in immune function and increases in chronic inflammation with age are a major contributor to age-related diseases. This Keystone Symposia conference will provide a venue for researchers from around the world to discuss current findings and fundamental research to understand the mechanisms underlying declining immune function, increasing chronic inflammation, and possible interventions. The meeting will address essential aspects of aging/longevity research, with particular emphasis on the immune system and inflammation including effects of immunosenescence on cancer, autoimmunity, vaccine response and infectious disease. Longitudinal studies on aging and immunity, frailty and effects on mortality, quality of life and survival will also be covered as well as biomarkers of the aging immune system, mechanisms for generating chronic inflammation including the SASP, telomeres and the microbiome, regulation of aging and age-related immune function, and therapeutic approaches to slow aging and/or improve the immune system. The adaptive, innate and mucosal immune systems will be covered as these systems have a significant impact on human aging. Questions to be addressed include: 1) What changes in the immune system contribute to the observed decline in immune function and increase in the chronic inflammatory state? 2) How do diseases of aging or decreased immunity develop, and what can be done to prevent or reverse them? To address these questions, the symposium will gather investigators from interdisciplinary areas on aging, inflammation and immunology and will focus first on the human and secondly the murine immune systems.
Scholarship Deadline: October 26 2017
Discounted Abstract Deadline: October 26 2017
Abstract Deadline: November 29 2017
Discounted Registration Deadline: December 21 2017
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
This activity was supported by an educational grant from Celgene Corporation
We gratefully acknowledge additional support from these exhibitors at this conference:

The Jackson Laboratory
We gratefully acknowledge additional support for this conference from:
Oncotarget
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1 R13 AG058412-01
Funding for this conference was made possible (in part) by 1 R13 AG058412-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 25 | 4:00PM - 8:00PM
Arrival and Registration
Room: Zilker North Lobby


Sunday, February 25 | 6:00PM - 8:00PM
Welcome Mixer
Room: Zilker North Lobby
No registration fees are used to fund alcohol served at this function.

Monday, February 26 | 7:30AM - 8:30AM
Breakfast
Room: Texas Ballroom


Monday, February 26 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Zilker Ballroom

Speaker 1 of 5
* Rafi Ahmed, Emory University School of Medicine, USA

Monday, February 26 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Zilker Ballroom

Speaker 2 of 5
* Bonnie B. Blomberg, University of Miami School of Medicine, USA

Monday, February 26 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Zilker Ballroom

Speaker 3 of 5
Rino Rappuoli, GlaxoSmithKline Vaccines, Italy
Vaccines 2018

Monday, February 26 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Zilker Ballroom

Speaker 4 of 5
Vishwa Deep Dixit, Yale University, USA
Immunometabolic Regulation of Healthspan

Monday, February 26 | 8:30AM - 10:00AM
Welcome and Keynote Session (Joint)
Room: Zilker Ballroom


Coffee Break

Monday, February 26 | 10:30AM - 12:45PM
Lifestyle, Epigenetics, Interventions
Room: Zilker 3-4

Speaker 1 of 6
* Vishwa Deep Dixit, Yale University, USA

Monday, February 26 | 10:30AM - 12:45PM
Lifestyle, Epigenetics, Interventions
Room: Zilker 3-4

Speaker 2 of 6
Nir Barzilai, Albert Einstein College of Medicine, USA
Moving to Translational Geroscience

Monday, February 26 | 10:30AM - 12:45PM
Lifestyle, Epigenetics, Interventions
Room: Zilker 3-4

Speaker 3 of 6
Manel Esteller, Josep Carreras Leukaemia Research Institute, Spain
Cancer Epigenetics: From Knowledge to Applications

Monday, February 26 | 10:30AM - 12:45PM
Lifestyle, Epigenetics, Interventions
Room: Zilker 3-4

Speaker 4 of 6
Valter D. Longo, University of Southern California, USA
Dietary Interventions

Monday, February 26 | 10:30AM - 12:45PM
Lifestyle, Epigenetics, Interventions
Room: Zilker 3-4

Speaker 5 of 6
Duygu Ucar, The Jackson Laboratory, USA
Short Talk: The Chromatin Accessibility Signature of Human Immune Aging Stems from CD8+ T Cells

Monday, February 26 | 10:30AM - 12:45PM
Lifestyle, Epigenetics, Interventions
Room: Zilker 3-4

Speaker 6 of 6
Leena Bharath, Boston University, USA
Short Talk: Effects of Metformin on Aging-Related Immune Cell Dysfunction

Monday, February 26 | 10:30AM - 12:45PM
Initial Reactions: Forming Innate Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 1 of 6
* Steven L. Reiner, Columbia University, USA


Monday, February 26 | 10:30AM - 12:45PM
Initial Reactions: Forming Innate Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 2 of 6
Lewis L. Lanier, University of California, San Francisco, USA
NK Cells Remember


Monday, February 26 | 10:30AM - 12:45PM
Initial Reactions: Forming Innate Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 3 of 6
Joseph C. Sun, Memorial Sloan Kettering Cancer Center, USA
Immunological Memory in Innate Lymphocytes


Monday, February 26 | 10:30AM - 12:45PM
Initial Reactions: Forming Innate Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 4 of 6
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Homeostatic Immunity to the Microbiota


Monday, February 26 | 10:30AM - 12:45PM
Initial Reactions: Forming Innate Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 5 of 6
Fadi G. Lakkis, University of Pittsburgh, USA
Short Talk: Specific Monocyte Memory to Allogeneic MHC Mediated by Paired Immunoglobulin Receptors (PIR)


Monday, February 26 | 10:30AM - 12:45PM
Initial Reactions: Forming Innate Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 6 of 6
Samantha B. Larsen, NYU Langone, USA
Short Talk: Inflammatory Memory Sensitizes Skin Epithelial Stem Cells to Tissue Damage


Monday, February 26 | 12:45PM - 5:00PM
On Own for Lunch


Monday, February 26 | 12:45PM - 1:00PM
Poster Setup
Room: Texas Ballroom


Monday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Texas Ballroom


Monday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Zilker North Lobby


Monday, February 26 | 5:00PM - 7:00PM
Longitudinal Studies on Aging and Immunity
Room: Zilker 3-4

Speaker 1 of 5
* Daniela Frasca, University of Miami, USA

Monday, February 26 | 5:00PM - 7:00PM
Longitudinal Studies on Aging and Immunity
Room: Zilker 3-4

Speaker 2 of 5
Graham Pawelec, University of Tübingen, Germany
Immune Parameters Associated with Mortality in the Elderly Are Context-Dependent: Lessons from Sweden, Holland and Belgium

Monday, February 26 | 5:00PM - 7:00PM
Longitudinal Studies on Aging and Immunity
Room: Zilker 3-4

Speaker 3 of 5
Luigi Ferrucci, NIA, National Institutes of Health, USA
Blood Inflammatory Mediators and Aging: Causes and Consequences

Monday, February 26 | 5:00PM - 7:00PM
Longitudinal Studies on Aging and Immunity
Room: Zilker 3-4

Speaker 4 of 5
Allison E. Aiello, University of North Carolina at Chapel Hill, USA
Stress, Immunity, Infection and Cellular Aging in Population-Based Studies

Monday, February 26 | 5:00PM - 7:00PM
Longitudinal Studies on Aging and Immunity
Room: Zilker 3-4

Speaker 5 of 5
Rebecca G. Reed, University of Kentucky, USA
Short Talk: Stress, Cytomegalovirus, and Immunosenescence: A Longitudinal Study of Older Adults

Monday, February 26 | 5:00PM - 7:15PM
CD8 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 1 of 6
* Rafi Ahmed, Emory University School of Medicine, USA


Monday, February 26 | 5:00PM - 7:15PM
CD8 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 2 of 6
Ananda W. Goldrath, University of California, San Diego, USA
Identification of Molecules Essential for CD8+ T Cell Residency in Non-Lymphoid Tissues and Tumors


Monday, February 26 | 5:00PM - 7:15PM
CD8 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 3 of 6
Dirk Hans Busch, Technical University Munich, Germany
Lineage Tracing of Memory CD8 T Cell Development


Monday, February 26 | 5:00PM - 7:15PM
CD8 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 4 of 6
Steven L. Reiner, Columbia University, USA
Metabolic Ambivalence and the Logic of Immunologic Memory


Monday, February 26 | 5:00PM - 7:15PM
CD8 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 5 of 6
Scott N. Mueller, University of Melbourne, Australia
Short Talk: Lymphoid Stromal Cells Support CD8 T Cell Priming and Memory


Monday, February 26 | 5:00PM - 7:15PM
CD8 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 6 of 6
Henrique Borges da Silva, University of Minnesota, USA
Short Talk: The Extracellular ATP Receptor P2RX7 Controls Metabolic Fitness of Long-Lived Memory CD8+ T Cells


Monday, February 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Texas Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, February 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Texas Ballroom


Tuesday, February 27 | 7:30AM - 8:30AM
Breakfast
Room: Texas Ballroom


Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
Room: Zilker 3-4

Speaker 1 of 8
* Janet M. Lord, University of Birmingham, UK

Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
Room: Zilker 3-4

Speaker 2 of 8
Judith Campisi, Buck Institute for Research on Aging, USA
Cellular Senescence and Inflammaging

Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
Room: Zilker 3-4

Speaker 3 of 8
Margaret M. Harnett, University of Glasgow, UK
Short Talk: Can the Parasitic Worm Product ES-62 Protect against Diet-Associated Pathologies in Aging Male and Female Mice?

Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
Room: Zilker 3-4

Speaker 4 of 8
Debbie Van Baarle, National Institute of Public Health and Environment, Netherlands
Short Talk: Proinflammatory Microbial Profiles Associate with Respiratory Infections in Older Adults

Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
Room: Zilker 3-4


Coffee Break

Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
Room: Zilker 3-4

Speaker 6 of 8
Daniela Frasca, University of Miami, USA
Adipose Tissue, Inflammation and Aging


Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
Room: Zilker 3-4

Speaker 7 of 8
Michael P. Cancro, University of Pennsylvania, USA
Mechanisms that Regulate Age-Associated B Cell Formation and Survival

Tuesday, February 27 | 8:30AM - 11:30AM
Mechanisms of Inflammaging
Room: Zilker 3-4

Speaker 8 of 8
Elizabeth A. Leadbetter, University of Texas Long School of Medicine, USA
Short Talk: iNKT Cells Support Tbet+ B Cells in Adipose Tissue and Are Required to Limit Symptoms of Metabolic Disease

Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 1 of 8
* Marion Pepper, University of Washington, USA


Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 2 of 8
Shane Crotty, La Jolla Institute for Immunology, USA
T Follicular Helper (Tfh) CD4 T Cells, Germinal Centers and the Generation of Memory


Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 3 of 8
Marc K. Jenkins, University of Minnesota Medical School, USA
Differentiation of CD4+ T Effector and Memory Cells during Bacterial Infection


Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2


Coffee Break


Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 5 of 8
Mark R. Boothby, Vanderbilt University Medical Center, USA
Hypoxia-Inducible Factors Regulate Metabolism and Function of B Cells and their Helpers in Antibody Responses


Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 6 of 8
Amy Weinmann, University of Alabama at Birmingham, USA
Role for Metabolites in T Cell Differentiation Programs


Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 7 of 8
Lillian B. Cohn, Chan Zuckerberg Biohub, USA
Short Talk: Clonally Expanded CD4+ T Cells Contribute to the HIV-1 Latent Reservoir and Display a Distinct Gene Signature upon Reactivation


Tuesday, February 27 | 8:30AM - 11:45AM
CD4 T Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 8 of 8
Raquel Furtado, Albert Einstein College of Medicine, USA
Short Talk: Expansion of Circulating CXCR3loPD-1+CXCR5+ Memory CD4+ T Helper Cells Correlates with Clinical Protection against Human Malaria


Tuesday, February 27 | 11:30AM - 5:00PM
On Own for Lunch


Tuesday, February 27 | 11:30AM - 1:00PM
Poster Setup
Room: Texas Ballroom


Tuesday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Texas Ballroom


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
Room: Zilker 3-4

Speaker 1 of 9
* Bonnie B. Blomberg, University of Miami School of Medicine, USA

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
Room: Zilker 3-4

Speaker 2 of 9
Petra Burilova, St. Anne´s University Hospital, Czech Republic
Accelerated Aging of Monocytes in Childhood and Adolescent Cancer Survivors

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
Room: Zilker 3-4

Speaker 3 of 9
Mati Mann, California Institute of Technology, USA
Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
Room: Zilker 3-4

Speaker 4 of 9
Nick P. Goplen, Mayo Clinic, USA
Non-Resolving Influenza Response in Geriatric Lungs

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
Room: Zilker 3-4

Speaker 5 of 9
Kylie Quinn, Monash University, Australia
Survival of Naïve CD8 T Cells During Aging Is Controlled by Homeostatic Signaling and Metabolic Remodeling

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
Room: Zilker 3-4

Speaker 6 of 9
Michelle Ratliff, University of Okalhoma Health Sciences Center, USA
Expression of the DNA-Binding Protein ARID3a, a Mediator of Human Hematopoiesis, Is Reduced in Hematopoietic Progenitors from Aged Individuals

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
Room: Zilker 3-4

Speaker 7 of 9
YanChun Peng, University of Oxford, UK
Identifying Age-Associated Immune Signatures on Influenza-Specific Human Memory T Cells using Single-Cell RNASeq

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
Room: Zilker 3-4

Speaker 8 of 9
Bo Ruem Yoon, Seoul National University College of Medicine, South Korea
SLC7A5-Mediated Leucine Influx Controls IL-1ß Production via Glycolytic Reprogramming in Human Monocytes/Macrophages

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1
Room: Zilker 3-4

Speaker 9 of 9
Juan I. Moliva, Vaccine Research Center, USA
Natural Aging Is Associated with Decreases in Lung Fluid Innate Immune Protein Function Driving Susceptibility to Mycobacterium Tuberculosis Infection

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 1 of 7
* Joseph C. Sun, Memorial Sloan Kettering Cancer Center, USA


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 2 of 7
Brian J. Laidlaw, University of California, San Francisco, USA
The Eph-Related Tyrosine Kinase Ligand Ephrin-B1 Marks Germinal Center and Memory Precursor B Cells


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 3 of 7
Anoma Nellore, University of Alabama at Birmingham, USA
T-bet Expression by Influenza-Specific Human Memory B Cells Is Differentially Regulated by Vaccine Platform and Prior Host Immunity and Correlates with Long-Lived Antibody Responses


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 4 of 7
Aakanksha Jain, UT Southwestern Medical Center, USA
T Cell Intrinsic IL-1R Signaling Licenses Effector Cytokine Production by Memory CD4 T Cells


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 5 of 7
Robin Stephens, University of Texas Medical Branch, USA
Mechanisms of Maintenance of Protection from Persistent Malaria Infection by CD4 Effector Memory T Cells


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 6 of 7
Thomas Ciucci, NCI, National Institutes of Health, USA
The Development of Memory CD4 T Cells Relies on a Thpok-Dependent Circuitry-Antagonizing Exhaustion Program


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 1: Memory I
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 7 of 7
Ning Jenny Jiang, University of Texas at Austin, USA
High-Throughput Single-Cell Linking of Antigen Specificities with T Cell Receptor Sequences using de novo Generated DNA-Linked MHC Tetramers


Tuesday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Zilker North Lobby


Tuesday, February 27 | 5:00PM - 7:15PM
New Ways to Generate B Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 1 of 6
* Shane Crotty, La Jolla Institute for Immunology, USA


Tuesday, February 27 | 5:00PM - 7:15PM
New Ways to Generate B Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 2 of 6
Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Heterogeneity of Memory B Cell Compartments


Tuesday, February 27 | 5:00PM - 7:15PM
New Ways to Generate B Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 3 of 6
David M. Tarlinton, Monash University, Australia
Molecular Regulation of Germinal Center Responses and B Cell Memory


Tuesday, February 27 | 5:00PM - 7:15PM
New Ways to Generate B Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 4 of 6
Scott D. Boyd, Stanford University, USA
B Cell Memory Repertoires in Vaccination and Infection


Tuesday, February 27 | 5:00PM - 7:15PM
New Ways to Generate B Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 5 of 6
Mary F. Fontana, University of Washington, USA
Short Talk: Expansion of an FCRL5+ B Cell Subset Resembling Atypical Memory B Cells in an Animal Model of Malaria


Tuesday, February 27 | 5:00PM - 7:15PM
New Ways to Generate B Cell Memory
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 6 of 6
Ali H. Ellebedy, Washington University School of Medicine, USA
Short Talk: Biphasic B Cell Responses to Adjuvanted H5N1 Influenza Virus Vaccination in Humans


Tuesday, February 27 | 5:00PM - 7:00PM
Frailty, Morbidity, Mortality/Survival
Room: Zilker 3-4

Speaker 1 of 5
* Nir Barzilai, Albert Einstein College of Medicine, USA

Tuesday, February 27 | 5:00PM - 7:00PM
Frailty, Morbidity, Mortality/Survival
Room: Zilker 3-4

Speaker 2 of 5
Janet M. Lord, University of Birmingham, UK
Exercise, Frailty, Inflammation and Aging

Tuesday, February 27 | 5:00PM - 7:00PM
Frailty, Morbidity, Mortality/Survival
Room: Zilker 3-4

Speaker 3 of 5
Janet E. McElhaney, Health Sciences North Research Institute, Canada
Frailty, Inflammation and Immunosenescence

Tuesday, February 27 | 5:00PM - 7:00PM
Frailty, Morbidity, Mortality/Survival
Room: Zilker 3-4

Speaker 4 of 5
Daniel Belsky, Duke University, USA
Quantification of Biological Aging: Implications for Clinical Trials and Extension of Healthspan

Tuesday, February 27 | 5:00PM - 7:00PM
Frailty, Morbidity, Mortality/Survival
Room: Zilker 3-4

Speaker 5 of 5
Leonard Daniël Samson, National Institute for Public Health and the Environment/ RIVM, Netherlands
Short Talk: The Relationship between Frailty, Disease and the Development of Immunosenescence over a Time Span of More
than 20 Years


Tuesday, February 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Texas Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, February 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Texas Ballroom


Wednesday, February 28 | 7:30AM - 8:30AM
Breakfast
Room: Texas Ballroom


Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
Room: Zilker 3-4

Speaker 1 of 8
* Judith Campisi, Buck Institute for Research on Aging, USA

Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
Room: Zilker 3-4

Speaker 2 of 8
* Michael P. Cancro, University of Pennsylvania, USA

Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
Room: Zilker 3-4

Speaker 3 of 8
Jorg J. Goronzy, Stanford University School of Medicine, USA
MicroRNA Regulation of T Cell Aging

Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
Room: Zilker 3-4

Speaker 4 of 8
Janko Nikolich-Zugich, University of Arizona College of Medicine, USA
T Cell Rejuvenation Requires Multiple Steps to Restore Immune Function with Aging

Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
Room: Zilker 3-4


Coffee Break

Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
Room: Zilker 3-4

Speaker 6 of 8
Laura Haynes, UConn Health, USA
The Impact of Aging on Response to Influenza Infection

Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
Room: Zilker 3-4

Speaker 7 of 8
Russell C. Ault, Texas Biomedical Research Institute, USA
Short Talk: Age-Related Differences in Peripheral Immunity at Tuberculosis Diagnosis in Humans

Wednesday, February 28 | 8:30AM - 11:30AM
Immunosenescence and Diseases
Room: Zilker 3-4

Speaker 8 of 8
Patricia J. Gearhart, NIA, National Institutes of Health, USA
Short Talk: Role of B Cells in Atherosclerosis

Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 1 of 8
* Ananda W. Goldrath, University of California, San Diego, USA


Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 2 of 8
Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Mitochondrial Priming By CD28


Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 3 of 8
Ronald N. Germain, NIAID, National Institutes of Health, USA
Using Multiplex Histocytometry to Relate Tissue Microanatomy to Immune Activation and Regulation


Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
This session is from Immunological Memory
Room: Zilker 1-2


Coffee Break


Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 5 of 8
Ellen A. Robey, University of California, Berkeley, USA
What Makes a Protective Anti-Toxoplasma T Cell Response?


Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 6 of 8
Susan M. Kaech, The Salk Institute, USA
Metabolic Control of Memory T Cell Lifespan


Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 7 of 8
John R. Teijaro, The Scripps Research Institute, USA
Short Talk: Cytokine-Mediated Expansion of Follicular Cytotoxic T Cells


Wednesday, February 28 | 8:30AM - 11:45AM
Immunoregulation
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 8 of 8
Kimberly S. Schluns, University of Texas MD Anderson Cancer Center, USA
Short Talk: Upregulating IL-15 in the Tumor Microenvironment Promotes Anti-Tumor Responses


Wednesday, February 28 | 11:30AM - 5:00PM
On Own for Lunch


Wednesday, February 28 | 11:30AM - 1:00PM
Poster Setup
Room: Texas Ballroom


Wednesday, February 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Texas Ballroom


Wednesday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Zilker North Lobby


Wednesday, February 28 | 5:00PM - 7:30PM
Inflammation, Biomarkers of the Aging Immune System and Poss
ible Treatments

Room: Zilker 3-4

Speaker 1 of 6
* Arne N. Akbar, University College London, UK

Wednesday, February 28 | 5:00PM - 7:30PM
Inflammation, Biomarkers of the Aging Immune System and Poss
ible Treatments

Room: Zilker 3-4

Speaker 2 of 6
Bonnie B. Blomberg, University of Miami School of Medicine, USA
B Cells, Inflammation and Aging in Vaccine Response

Wednesday, February 28 | 5:00PM - 7:30PM
Inflammation, Biomarkers of the Aging Immune System and Poss
ible Treatments

Room: Zilker 3-4

Speaker 3 of 6
Susan L. Swain, University of Massachusetts Medical School, USA
Optimum Ag Presentation Can Counteract Age-Related Defects in CD4 T Cell Immunity and Lead to Better CD4 T and B Cell Effector and Memory Responses

Wednesday, February 28 | 5:00PM - 7:30PM
Inflammation, Biomarkers of the Aging Immune System and Poss
ible Treatments

Room: Zilker 3-4

Speaker 4 of 6
Luca Pangrazzi, University of Innsbruck, Austria
Adaptive Immunity in the Bone Marrow in Old Age

Wednesday, February 28 | 5:00PM - 7:30PM
Inflammation, Biomarkers of the Aging Immune System and Poss
ible Treatments

Room: Zilker 3-4

Speaker 5 of 6
Joan Mannick, resTORbio, USA
TORC1 Inhibition as a Potential Immunotherapy to Decrease Infections in the Elderly

Wednesday, February 28 | 5:00PM - 7:30PM
Inflammation, Biomarkers of the Aging Immune System and Poss
ible Treatments

Room: Zilker 3-4

Speaker 6 of 6
Suresh Pallikkuth, University of Miami, USA
Short Talk: Frequency and Function of Antigen-Specific Peripheral T Follicular Helper Cells Are Impaired by Basal Immune
Activation and Impact Flu Vaccine Response in Biologic Aging with and without HIV Infection


Wednesday, February 28 | 5:00PM - 7:15PM
Imprinting Memory in Tissues
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 1 of 6
* Linda S. Cauley, University of Connecticut Health Center, USA


Wednesday, February 28 | 5:00PM - 7:15PM
Imprinting Memory in Tissues
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 2 of 6
David B. Masopust, University of Minnesota, USA
Functions of Trm Cells


Wednesday, February 28 | 5:00PM - 7:15PM
Imprinting Memory in Tissues
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 3 of 6
Donna L. Farber, Columbia University Medical Center, USA
Tissue Specialization and Maintenance of Human Memory T Cells


Wednesday, February 28 | 5:00PM - 7:15PM
Imprinting Memory in Tissues
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 4 of 6
Marion Pepper, University of Washington, USA
Pathological Lung Resident Memory Th2 Cells


Wednesday, February 28 | 5:00PM - 7:15PM
Imprinting Memory in Tissues
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 5 of 6
Laura K. Mackay, University of Melbourne, Australia
Short Talk: Local Maintenance of a Proliferating Tissue-Resident Memory T Cell Pool following Antiviral Recall Responses


Wednesday, February 28 | 5:00PM - 7:15PM
Imprinting Memory in Tissues
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 6 of 6
Angela Pizzolla, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Australia
Short Talk: Nasal Tissue-Resident Memory CD8+ T Cells Prevent Pulmonary Influenza A Virus Infection


Wednesday, February 28 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Texas Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, February 28 | 7:30PM - 10:00PM
Poster Session 3
Room: Texas Ballroom


Thursday, March 01 | 7:30AM - 8:30AM
Breakfast
Room: Texas Ballroom


Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 1 of 8
* Donna L. Farber, Columbia University Medical Center, USA

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 2 of 8
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Lessons from the Analysis of the Immune Response to P. falciparum

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 3 of 8
Bali Pulendran, Stanford University School of Medicine, USA
Lessons from Successful Human Vaccines

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom


Coffee Break

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 5 of 8
Tyler J. Curiel, University of Texas Health, USA
Challenges in Successful Immunotherapy of Cancer in Aged Individuals

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 6 of 8
Arne N. Akbar, University College London, UK
Targeting MAP Kinase Signaling to Enhance Immunity during Aging

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 7 of 8
Katherine Kedzierska, University of Melbourne, Australia
Short Talk: Dynamics of CD8+ T Cell Memory Repertoires across Human Life-Span and Tissue Compartments

Thursday, March 01 | 8:30AM - 11:45AM
Therapeutic Approaches to Vaccines and Aging (Joint)
Room: Zilker Ballroom

Speaker 8 of 8
Sara Van Den Berg, National Institute of Public Health and Environment, Netherlands
Short Talk: T Cell Responses to Influenza Infection in Elderly Are Impaired by Latent Cytomegalovirus (CMV) Infection

Thursday, March 01 | 11:45AM - 5:00PM
On Own for Lunch


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
Room: Zilker 3-4

Speaker 1 of 7
* Graham Pawelec, University of Tübingen, Germany

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
Room: Zilker 3-4

Speaker 2 of 7
Christina Camell, University of Minnesota, USA
NLRP3 Inflammasome Controls Adipose Tissue B Cell Accumulation during Aging

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
Room: Zilker 3-4

Speaker 3 of 7
Claire Gustafson, Stanford University, USA
Differentiation- and Age-Related MicroRNA Profiling Reveals Two Dimensions of CD8 T Cell Aging

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
Room: Zilker 3-4

Speaker 4 of 7
Abhijit Kale, Buck Institute for Research on Aging, USA
Elimination of Senescent Cells by Innate Immune System

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
Room: Zilker 3-4

Speaker 5 of 7
Mladen Jergovic, University of Arizona, USA
Expression of Ly6C Defines a Subpopulation of Naïve CD8 T Cells with a Rapid Effector Function which Is Expanded Under 'non-SPF' Conditions

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
Room: Zilker 3-4

Speaker 6 of 7
Susan Baldwin, Infectious Disease Research Institute, USA
Adjuvanted H1N1 Vaccines Improve Immune Responses in Young and Aged Mice

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2
Room: Zilker 3-4

Speaker 7 of 7
Andy Schile, The Jackson Laboratory, USA
Lessons Learned From Managing Aged Colonies of C57BL/6J Mice

Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 1 of 9
* Susan M. Kaech, The Salk Institute, USA


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 2 of 9
Allan J. Zajac, University of Alabama, Birmingham, USA
The Production of IL-2 by CD8 T Cells Shapes Their Fate Decisions and Protective Efficacy


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 3 of 9
Enrico Lugli, Humanitas Clinical and Research Center, Italy
High-Dimensional Single Cell Analysis of the Tumor CD8+ T Cell Infiltrate Identifies Long-Lived Memory CD8+ T Cells with Enhanced Stemness


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 4 of 9
Philip Ansumana Hull, Bristol-Myers Squibb, USA
Metabolic Reprogramming of Human CD8+ Memory T Cells through Loss of SIRT1


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 5 of 9
Vandana Kalia, University of Washington, USA
Anatomic and Cellular Regulators of Metabolic Remodeling during Effector CTL to Memory Conversion


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 6 of 9
Dietmar Herndler-Brandstetter, Medical University of Vienna, Austria
Developmental Plasticity of KLRG1+ Effector CD8+ T Cells Promotes Protective
Immunity


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 7 of 9
Paul Richard Dunbar, SQZ Biotech, USA
Pulmonary Monocytes Promote the Establishment of Lung Tissue-Resident CD8 T Cell Memory following Influenza Infection


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 8 of 9
Linda S. Cauley, University of Connecticut Health Center, USA
Innate Cytokine Stimulation Plays a Decisive Role in Late Differentiation of Activated CTLs


Thursday, March 01 | 2:30PM - 4:30PM
Workshop 2: Memory II
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 9 of 9
Peter Cockerill, University of Birmingham, UK
Immunological Memory in T Cells is Established via T Cell Receptor Signaling which Creates Stably Maintained Active Chromatin Domains at Immune Response Genes


Thursday, March 01 | 4:30PM - 5:00PM
Coffee Available
Room: Zilker North Lobby


Thursday, March 01 | 5:00PM - 6:15PM
Genetic, Epigenetic, Transcriptomic Regulation of Aging and
Age-Related Diseases

Room: Zilker 3-4

Speaker 1 of 4
* Bonnie B. Blomberg, University of Miami School of Medicine, USA

Thursday, March 01 | 5:00PM - 6:15PM
Genetic, Epigenetic, Transcriptomic Regulation of Aging and
Age-Related Diseases

Room: Zilker 3-4

Speaker 2 of 4
* Graham Pawelec, University of Tübingen, Germany

Thursday, March 01 | 5:00PM - 6:15PM
Genetic, Epigenetic, Transcriptomic Regulation of Aging and
Age-Related Diseases

Room: Zilker 3-4

Speaker 3 of 4
Albert C. Shaw, Yale School of Medicine, USA
Consequences of Aging on Signatures of Influenza Vaccine Response

Thursday, March 01 | 5:00PM - 6:15PM
Genetic, Epigenetic, Transcriptomic Regulation of Aging and
Age-Related Diseases

Room: Zilker 3-4

Speaker 4 of 4
Ruth R. Montgomery, Yale University School of Medicine, USA
Short Talk: Expression and Signaling of TAM Receptor Inflammatory Regulators in Aging

Thursday, March 01 | 5:00PM - 6:00PM
The Wear and Tear on T Cells in Chronic Infection and Tumors
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 1 of 3
* Susan M. Kaech, The Salk Institute, USA


Thursday, March 01 | 5:00PM - 6:00PM
The Wear and Tear on T Cells in Chronic Infection and Tumors
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 2 of 3
E. John Wherry, University of Pennsylvania, USA
T Cell Exhaustion


Thursday, March 01 | 5:00PM - 6:00PM
The Wear and Tear on T Cells in Chronic Infection and Tumors
This session is from Immunological Memory
Room: Zilker 1-2

Speaker 3 of 3
Rafi Ahmed, Emory University School of Medicine, USA
Human CD8 T Cell Memory


Thursday, March 01 | 6:15PM - 7:00PM
Closing Keynote Address
Room: Zilker 3-4

Speaker 1 of 3
* Bonnie B. Blomberg, University of Miami School of Medicine, USA

Thursday, March 01 | 6:15PM - 7:00PM
Closing Keynote Address
Room: Zilker 3-4

Speaker 2 of 3
* Graham Pawelec, University of Tübingen, Germany

Thursday, March 01 | 6:15PM - 7:00PM
Closing Keynote Address
Room: Zilker 3-4

Speaker 3 of 3
Claudio Franceschi, University of Bologna, Italy
Aging, Inflammation and Immunity

Thursday, March 01 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Immunological Memory
Room: Zilker 1-2


Thursday, March 01 | 7:00PM - 7:15PM
Discussion of Meeting, Summary, Conclusion and Mouse-Human C
onnections

Room: Zilker 3-4

Speaker 1 of 2
* Bonnie B. Blomberg, University of Miami School of Medicine, USA

Thursday, March 01 | 7:00PM - 7:15PM
Discussion of Meeting, Summary, Conclusion and Mouse-Human C
onnections

Room: Zilker 3-4

Speaker 2 of 2
* Graham Pawelec, University of Tübingen, Germany

Thursday, March 01 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Texas Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, March 01 | 8:00PM - 11:00PM
Entertainment
Room: Texas Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 01 | 8:00PM - 11:00PM
Cash Bar
Room: Texas Ballroom


Friday, March 02 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.