Web Desc
Chromatin Architecture and Chromosome Organization
joint with Gene Control in Development and Disease
Organizer(s): Edith Heard and Peter Fraser
Date: March 23 - 27, 2018
Location: Whistler Conference Centre, Whistler, BC, Canada
Supported by Directors' Fund
Summary of Meeting:
Understanding the principles governing genome regulation is one of the major challenges now facing biomedical research in the 21st century. Deciphering structure-activity relationships of the genome and its partners in the context of the cell nucleus is a necessary step for understanding the basis of development and disease, as well as for the elaboration of strategies against particular forms of cancers and genetic disorders. The genome is not a linear molecule of DNA randomly distributed in the nucleus, but exists as a three-dimensional (3D) object, intricately folded and packaged, structured around nuclear bodies and landmarks, acted upon by countless force-generating nano-machines and remodeling factors. With the recent advances that have been made in microscopy, biochemistry and modeling, the time is ripe to fully address the study of the genome in 3D space and time and consider it as a complex, dynamic biological system. Up until recently, many of the scientists involved in chromatin biology and epigenetics would attend meetings dedicated to this topic and would not necessarily interface with scientists using advanced imaging or physical and mathematical modeling approaches. This meeting will bring together some of the world’s leading experts and emerging talents at the interface of these topics to explore chromosome architecture and its dynamic relationship with genome function. Specifically, it will explore: 1) Chromatin structure and how this relates to gene expression and genome functions such as DNA replication and repair; 2) Chromosome conformation and the new insights into genome organization that have emerged using new technologies; 3) The nature of the chromatin partners (proteins, RNAs) that underlie chromatin folding and functions and their dynamic relationships in different contexts (cell cycle, development, environmentally induced changes, etc.); 4) Emerging imaging technologies and microscopy and the answers they are bringing to the dynamics of chromatin and chromosome architecture; and 5) New physical and mathematical modeling approaches to further our understanding of the principles governing chromatin architecture.
Scholarship Deadline: November 28 2017
Discounted Abstract Deadline: November 28 2017
Abstract Deadline: December 20 2017
Discounted Registration Deadline: January 17 2018
We gratefully acknowledge additional support from these exhibitors at this conference:
Arima Genomics, Inc.The Paul G. Allen Frontiers Group
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, March 23 | 4:00PM - 8:00PM
Arrival and Registration
Room: Grand Foyer


Friday, March 23 | 6:00PM - 8:00PM
Welcome Mixer
Room: Grand Foyer
No registration fees are used to fund alcohol served at this function.

Saturday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Saturday, March 24 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky C

Speaker 1 of 3
* Edith Heard, European Molecular Biology Laboratory, Germany

Saturday, March 24 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky C

Speaker 2 of 3
* Peter Fraser, Florida State University, USA

Saturday, March 24 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky C

Speaker 3 of 3
Job Dekker, University of Massachusetts Medical School, USA
Folding, Unfolding and Refolding of Genomes

Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
Room: Sea to Sky C

Speaker 1 of 8
* Wendy A. Bickmore, University of Edinburgh, UK

Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
Room: Sea to Sky C

Speaker 2 of 8
* William Stafford Noble, University of Washington, USA

Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
Room: Sea to Sky C

Speaker 3 of 8
Carlo Vermeulen, Hubrecht Institute, Netherlands
Locus-Specific Enhancer Hubs and Architectural Loop Collisions Uncovered from Single Allele DNA Topologies

Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
Room: Sea to Sky C


Coffee Break

Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
Room: Sea to Sky C

Speaker 5 of 8
Peter Fraser, Florida State University, USA
Chromosome Architecture Dynamics Using Single Cell HiC

Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
Room: Sea to Sky C

Speaker 6 of 8
Suzana Hadjur, University College London, UK
Role of Cohesin Complex Diversity in Genome Organization and Cell Fate Determination

Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
Room: Sea to Sky C

Speaker 7 of 8
Maciej Piotr Zaczek, Institute of Molecular Pathology, Austria
Short Talk: CTCF Constrains Cohesin Translocation along DNA

Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
Room: Sea to Sky C

Speaker 8 of 8
Elphège P. Nora, University of California San Francisco, USA
Short Talk: Dissecting the Molecular Connection between CTCF and Cohesin

Saturday, March 24 | 9:00AM - 11:30AM
Basics
This session is from Gene Control
Room: Sea to Sky B

Speaker 1 of 7
* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA


Saturday, March 24 | 9:00AM - 11:30AM
Basics
This session is from Gene Control
Room: Sea to Sky B

Speaker 2 of 7
Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany
Integrated Structural Biology of Gene Transcription


Saturday, March 24 | 9:00AM - 11:30AM
Basics
This session is from Gene Control
Room: Sea to Sky B


Coffee Break


Saturday, March 24 | 9:00AM - 11:30AM
Basics
This session is from Gene Control
Room: Sea to Sky B

Speaker 4 of 7
Karen Adelman, Harvard Medical School, USA
Pause Control in Development and Disease


Saturday, March 24 | 9:00AM - 11:30AM
Basics
This session is from Gene Control
Room: Sea to Sky B

Speaker 5 of 7
Ronald M. Evans, HHMI/The Salk Institute, USA
Vitamin D and Dysregulated Transcription


Saturday, March 24 | 9:00AM - 11:30AM
Basics
This session is from Gene Control
Room: Sea to Sky B

Speaker 6 of 7
Xiong Ji, Peking University, China
Short Talk: RNAPII Elimination Reveals Transcriptional-Dependent Three-Dimensional Chromatin Landscape


Saturday, March 24 | 9:00AM - 11:30AM
Basics
This session is from Gene Control
Room: Sea to Sky B

Speaker 7 of 7
Diego Villar Lozano, University of Cambridge, UK
Short Talk: The Gene Expression Consequences of Mammalian Regulatory Evolution


Saturday, March 24 | 11:30AM - 5:00PM
On Own for Lunch


Saturday, March 24 | 11:30AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Saturday, March 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
Room: Sea to Sky C

Speaker 1 of 9
* Job Dekker, University of Massachusetts Medical School, USA

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
Room: Sea to Sky C

Speaker 2 of 9
* Thoru Pederson, University of Massachusetts Medical School, USA
CRISPR Barcoding Reveals Changes in Interphase Chromosome Conformation and Dynamics in Human Cells

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
Room: Sea to Sky C

Speaker 3 of 9
Josef Redolfi, Friedrich Miescher Institute for Biomedical Research, Switzerland
Crosslinking- and Ligation-Free Detection of Chromosomal Interactions using DamID and Physical Modeling

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
Room: Sea to Sky C

Speaker 4 of 9
Kerstin Bystricky, University of Toulouse, France
Chromatin Dynamics in Real Time and at Nanoscale Resolution Reveal Transcription-Dependent Long-Range Correlation

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
Room: Sea to Sky C

Speaker 5 of 9
Saumya Agrawal, RIKEN, Yokohama Campus, Japan
Association between Three-Dimensional Localization and Function of Long Noncoding RNAs

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
Room: Sea to Sky C

Speaker 6 of 9
Sofia Quinodoz, California Institute of Technology, USA
Higher-Order Inter-Chromosomal Hubs Shape 3-Dimensional Genome Organization in the Nucleus

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
Room: Sea to Sky C

Speaker 7 of 9
Valerio Orlando, King Abdullah University of Science and Technology, Saudi Arabia
Ago1 in Association with NEAT1 lncRNA Contributes to Nuclear and 3D Chromatin Architecture in Human Cells

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
Room: Sea to Sky C

Speaker 8 of 9
Alice Sherrard, University of Bristol, UK
Imaging Chromatin Dynamics Reveals a Novel Mechanism for Nuclear Organization after Cell Division

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
Room: Sea to Sky C

Speaker 9 of 9
Marlies E. Oomen, University of Massachusetts Medical School, USA
Cell Cycle Dynamics of CTCF Binding and its Relation to Chromosome Organization

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 1 of 9
* Karen Adelman, Harvard Medical School, USA


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 2 of 9
* Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 3 of 9
Richard G. Jenner, University College London, UK
RNA Antagonizes the Interaction of PRC2 and Other Epigenetic Modifiers with Chromatin


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 4 of 9
Natalia B. Ivanova, Yale University School of Medicine, USA
Chromatin-Associated Factors Dppa2 and Dppa4 Guide Epigenetic Remodeling during Cellular Reprogramming


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 5 of 9
Ido Sagi, Hebrew University of Jerusalem, Israel
Studying Haploidy and Parental Imprinting in Human Pluripotent Stem Cells


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 6 of 9
Aydan Bulut-Karslioglu, University of California, San Francisco, USA
Chd1-Mediated Repair of Physiological DNA Breaks Sustains Hypertranscription and Proliferation of ES Cells


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 7 of 9
Ruben Esse, Boston University, USA
DOT1L in Enhancer Regulation


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 8 of 9
Sudhir Thakurela, Harvard University, USA
Genetic Determinants and Epigenetic Effects of Pioneer Factor Occupancy during Development


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 9 of 9
Elodie Emilie Thierion, University of Cambridge, UK
Gene Regulation Dynamics and Evolution in Somites


Saturday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Saturday, March 24 | 5:00PM - 7:00PM
Control Elements (Joint)
Room: Sea to Sky B/C

Speaker 1 of 6
* Bing Ren, Ludwig Institute for Cancer Research, USA

Saturday, March 24 | 5:00PM - 7:00PM
Control Elements (Joint)
Room: Sea to Sky B/C

Speaker 2 of 6
* Mikhail Spivakov, Babraham Institute, UK

Saturday, March 24 | 5:00PM - 7:00PM
Control Elements (Joint)
Room: Sea to Sky B/C

Speaker 3 of 6
Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany
Functional Insights into Genome Topology and Enhancer Function during Embryonic Development

Saturday, March 24 | 5:00PM - 7:00PM
Control Elements (Joint)
Room: Sea to Sky B/C

Speaker 4 of 6
Joanna Wysocka, Stanford University, USA
Enhancers in Development

Saturday, March 24 | 5:00PM - 7:00PM
Control Elements (Joint)
Room: Sea to Sky B/C

Speaker 5 of 6
Rajat Gupta, Massachusetts General Hospital, USA
Short Talk: A Genetic Variant Associated with Five Vascular Diseases Distally Regulates Gene Expression via Long-Range Enhancer Interactions

Saturday, March 24 | 5:00PM - 7:00PM
Control Elements (Joint)
Room: Sea to Sky B/C

Speaker 6 of 6
Jeff Alexander, University of California, San Francisco, USA
Short Talk: Live-Cell Imaging Reveals Enhancer-Dependent Sox2 Transcription Is Not Associated with Enhancer Proximity

Saturday, March 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Saturday, March 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A


Sunday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 1 of 8
* Stavros Lomvardas, Columbia University, USA

Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 2 of 8
* Suzana Hadjur, University College London, UK

Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 3 of 8
Juanma Vaquerizas, Max Planck Institute for Molecular Biomedicine, Germany
Chromatin Architecture during Early Development

Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 4 of 8
Bing Ren, Ludwig Institute for Cancer Research, USA
Regulation of Lineage-Specific Chromatin Organization at Enhancers


Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C


Coffee Break

Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 6 of 8
Wendy A. Bickmore, University of Edinburgh, UK
The Remote Control of Gene Expression

Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 7 of 8
Edda G. Schulz, Max Planck Institute for Molecular Genetics, Germany
Two Coupled Feedback Loops Explain Random Mono-Allelic Xist Upregulation at the Onset of X-Chromosome Inactivation

Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 8 of 8
Julie Ahringer, University of Cambridge, UK
Short Talk: ARC-C for Genome-Wide Analysis of Regulatory Element Interactions at High Resolution

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 1 of 20
* Edith Heard, European Molecular Biology Laboratory, Germany

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 2 of 20
* Richard A. Young, Whitehead Institute for Biomedical Research, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 3 of 20
Sharon Ahmad, Journal of Cell Science, UK

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 4 of 20
Marie Bao, Cell Press, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 5 of 20
Katherine Brown, Company of Biologists, UK

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 6 of 20
Melina Casadio, Rockefeller University Press, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 7 of 20
Alex Eccleston, Nature, UK, UK

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 8 of 20
Markus Elsner, Nature Biotechnology, Germany

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 9 of 20
Tiago Faial, Nature Genetics, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 10 of 20
Sarah Geisler, Cell, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 11 of 20
Di Jiang, PLOS Biology, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 12 of 20
Steve Mao, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 13 of 20
Carolina Perdigoto, Nature Communications, UK

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 14 of 20
Nicole Rusk, Nature Methods, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 15 of 20
Rupa Sarkar, Lancet Digital Health, UK

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 16 of 20
Esther Schnapp, European Molecular Biology Organization, Germany

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 17 of 20
Julie Sollier, Developmental Cell, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 18 of 20
Anke Sparmann, Nature Structural and Molecular Biology, UK

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 19 of 20
Ruth Zearfoss, Cell Press, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 20 of 20
Eytan Zlotorynski, Nature Reviews Molecular Cell Biology, UK

Sunday, March 25 | 11:00AM - 5:00PM
On Own for Lunch


Sunday, March 25 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Sunday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Sunday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Sunday, March 25 | 5:00PM - 7:00PM
Spatio-Temporal Dynamics of Chromatin
Room: Sea to Sky C

Speaker 1 of 6
* Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany

Sunday, March 25 | 5:00PM - 7:00PM
Spatio-Temporal Dynamics of Chromatin
Room: Sea to Sky C

Speaker 2 of 6
* Juanma Vaquerizas, Max Planck Institute for Molecular Biomedicine, Germany

Sunday, March 25 | 5:00PM - 7:00PM
Spatio-Temporal Dynamics of Chromatin
Room: Sea to Sky C

Speaker 3 of 6
Stavros Lomvardas, Columbia University, USA
Interchromosomal Interactions Regulate Singular Olfactory Receptor Choice

Sunday, March 25 | 5:00PM - 7:00PM
Spatio-Temporal Dynamics of Chromatin
Room: Sea to Sky C

Speaker 4 of 6
Victor G. Corces, Emory University School of Medicine, USA
Mechanisms of Transgenerational Inheritance

Sunday, March 25 | 5:00PM - 7:00PM
Spatio-Temporal Dynamics of Chromatin
Room: Sea to Sky C

Speaker 5 of 6
Amos Tanay, Weizmann Institute, Israel
Single Cell Approaches in Epigenomics and 3D Chromosome Organization

Sunday, March 25 | 5:00PM - 7:00PM
Spatio-Temporal Dynamics of Chromatin
Room: Sea to Sky C

Speaker 6 of 6
Yong Hoon Kim, University of Pennsylvania School of Medicine, USA
Short Talk: Rev-erb alpha Dynamically Modulates Chromatin Looping to Control Circadian Gene Transcription

Sunday, March 25 | 5:00PM - 7:00PM
Epigenetics
This session is from Gene Control
Room: Sea to Sky B

Speaker 1 of 6
* Geeta J. Narlikar, University of California, San Francisco, USA


Sunday, March 25 | 5:00PM - 7:00PM
Epigenetics
This session is from Gene Control
Room: Sea to Sky B

Speaker 2 of 6
* Joseph R. Ecker, The Salk Institute for Biological Studies, USA


Sunday, March 25 | 5:00PM - 7:00PM
Epigenetics
This session is from Gene Control
Room: Sea to Sky B

Speaker 3 of 6
Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Epigenetic Pathways Regulating Cell Fate


Sunday, March 25 | 5:00PM - 7:00PM
Epigenetics
This session is from Gene Control
Room: Sea to Sky B

Speaker 4 of 6
Oliver J. Rando, University of Massachusetts Medical School, USA
Small RNA Trafficking during Sperm Epididymal Maturation Is Essential for Early Development in Mammals


Sunday, March 25 | 5:00PM - 7:00PM
Epigenetics
This session is from Gene Control
Room: Sea to Sky B

Speaker 5 of 6
Edith Heard, European Molecular Biology Laboratory, Germany

Developmental Dynamics of X-Chromosome Structure


Sunday, March 25 | 5:00PM - 7:00PM
Epigenetics
This session is from Gene Control
Room: Sea to Sky B

Speaker 6 of 6
Zachary Hugh Harvey, Stanford University, USA
Short Talk: A Prion That Mediates Meiotic Inheritances of Activated Chromatin States


Sunday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Sunday, March 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Monday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
Room: Sea to Sky C

Speaker 1 of 10
* Karen L. Reddy, Johns Hopkins University, USA

Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
Room: Sea to Sky C

Speaker 2 of 10
* Leonid Mirny, Massachusetts Institute of Technology, USA

Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
Room: Sea to Sky C

Speaker 3 of 10
Jane A. Skok, New York University School of Medicine, USA
The Mechanisms Underlying the Impact of MMSET Overexpression on Gene Regulation in Multiple Myeloma

Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
Room: Sea to Sky C

Speaker 4 of 10
Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Genome Architecture Mapping: Exploring Mechanisms of 3D Chromatin Folding in Rare Cell Types

Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
Room: Sea to Sky C


Coffee Break

Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
Room: Sea to Sky C

Speaker 6 of 10
Mikhail Spivakov, Babraham Institute, UK
Mapping Genomic Regulatory Architecture and Interpreting Non-coding Variation with Promoter Capture Hi-C

Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
Room: Sea to Sky C

Speaker 7 of 10
Kevin G. Monahan, Columbia University, USA
Short Talk: Ldb1 Is Required for the Formation of a Multi-Chromosomal Enhancer Hub that Governs Singular Olfactory Receptor Transcription

Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
Room: Sea to Sky C

Speaker 8 of 10
Alistair Boettiger, Stanford University, USA
Short Talk: Nanoscale Visualization of cis-Regulation in Development using ORCA

Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
Room: Sea to Sky C

Speaker 9 of 10
Jean J. Gautier, Columbia University, College of Physicians and Surgeons, USA
Short Talk: Nuclear Actin Polymerization Drives DNA Double-Strand Break Mobility and Clustering for Homology-Directed Repair

Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
Room: Sea to Sky C

Speaker 10 of 10
Rani E. George, Dana-Farber Cancer Institute, USA
Short Talk: The CTCF Paralog BORIS Promotes Novel Chromatin Regulatory Interactions in Cancer Cells

Monday, March 26 | 8:00AM - 11:30AM
New Models
This session is from Gene Control
Room: Sea to Sky B

Speaker 1 of 10
* Magdalena D. Zernicka-Goetz, Caltech and University of Cambridge, UK


Monday, March 26 | 8:00AM - 11:30AM
New Models
This session is from Gene Control
Room: Sea to Sky B

Speaker 2 of 10
* Yonatan Stelzer, Weizmann Institute of Science, Israel


Monday, March 26 | 8:00AM - 11:30AM
New Models
This session is from Gene Control
Room: Sea to Sky B

Speaker 3 of 10
Phillip A. Sharp, Massachusetts Institute of Technology, USA
Phase Separation in Transcription Control


Monday, March 26 | 8:00AM - 11:30AM
New Models
This session is from Gene Control
Room: Sea to Sky B

Speaker 4 of 10
Ibrahim Cissé, Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Live Mammalian Cells


Monday, March 26 | 8:00AM - 11:30AM
New Models
This session is from Gene Control
Room: Sea to Sky B


Coffee Break


Monday, March 26 | 8:00AM - 11:30AM
New Models
This session is from Gene Control
Room: Sea to Sky B

Speaker 6 of 10
Geeta J. Narlikar, University of California, San Francisco, USA
Phase-Separation in Heterochromatin Formation


Monday, March 26 | 8:00AM - 11:30AM
New Models
This session is from Gene Control
Room: Sea to Sky B

Speaker 7 of 10
Ankur Jain, University of California, San Francisco, USA
RNA Phase Separation and Neurodegenerative Disease


Monday, March 26 | 8:00AM - 11:30AM
New Models
This session is from Gene Control
Room: Sea to Sky B

Speaker 8 of 10
Sheila Teves, University of California, Berkeley, USA
Short Talk: A Stable Mode of Bookmarking by TBP Recruits RNA Polymerase II to Mitotic Chromosomes


Monday, March 26 | 8:00AM - 11:30AM
New Models
This session is from Gene Control
Room: Sea to Sky B

Speaker 9 of 10
Mounia Lagha, Centre National de la Recherche Scientifique, France
Short Talk: Zelda and Transcriptional Memory in Drosophila Embryos


Monday, March 26 | 8:00AM - 11:30AM
New Models
This session is from Gene Control
Room: Sea to Sky B

Speaker 10 of 10
Yuelin Song, Massachusetts Institute of Technology, USA
Short Talk: Dynamic DNA Methylation Heterogeneity at Super-Enhancers in Single-Cells


Monday, March 26 | 11:15AM - 5:00PM
On Own for Lunch


Monday, March 26 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Monday, March 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Monday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Monday, March 26 | 5:00PM - 7:00PM
Integrating Chromatin States and Genome Architecture to Unde
rstand Genome Function

Room: Sea to Sky C

Speaker 1 of 6
* Giacomo Cavalli, Institute of Human Genetics, France

Monday, March 26 | 5:00PM - 7:00PM
Integrating Chromatin States and Genome Architecture to Unde
rstand Genome Function

Room: Sea to Sky C

Speaker 2 of 6
* Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland

Monday, March 26 | 5:00PM - 7:00PM
Integrating Chromatin States and Genome Architecture to Unde
rstand Genome Function

Room: Sea to Sky C

Speaker 3 of 6
John A. Stamatoyannopoulos, Altius Institute for Biomedical Sciences, USA
Transcriptional Circuitry and Regulatory Landscapes

Monday, March 26 | 5:00PM - 7:00PM
Integrating Chromatin States and Genome Architecture to Unde
rstand Genome Function

Room: Sea to Sky C

Speaker 4 of 6
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Phase Separation and Genome Architecture

Monday, March 26 | 5:00PM - 7:00PM
Integrating Chromatin States and Genome Architecture to Unde
rstand Genome Function

Room: Sea to Sky C

Speaker 5 of 6
William J. Greenleaf, Stanford University, USA
Understanding the Physical Genome

Monday, March 26 | 5:00PM - 7:00PM
Integrating Chromatin States and Genome Architecture to Unde
rstand Genome Function

Room: Sea to Sky C

Speaker 6 of 6
Jiao Sima, Florida State University, USA
Short Talk: CRISPR Dissection of a Replication Domain Reveals Discrete Internal cis Elements Regulating Replication Timing and Chromatin Compartment

Monday, March 26 | 5:00PM - 7:00PM
Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 1 of 6
* Natalia B. Ivanova, Yale University School of Medicine, USA


Monday, March 26 | 5:00PM - 7:00PM
Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 2 of 6
* Peter C. Scacheri, Case Western Reserve University, USA


Monday, March 26 | 5:00PM - 7:00PM
Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 3 of 6
Eliezer Calo, Massachusetts Institute of Technology, USA
Tissue-Selective Effects of Nucleolar Stress and rDNA Damage in Developmental Disorders


Monday, March 26 | 5:00PM - 7:00PM
Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 4 of 6
Magdalena D. Zernicka-Goetz, Caltech and University of Cambridge, UK
Building the Mammalian Embryo in vivo and in vitro


Monday, March 26 | 5:00PM - 7:00PM
Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 5 of 6
Joseph R. Ecker, The Salk Institute for Biological Studies, USA
Single Cell Methylomes Reveal Neuronal Populations and Regulatory Elements in the Mammalian Brain


Monday, March 26 | 5:00PM - 7:00PM
Development
This session is from Gene Control
Room: Sea to Sky B

Speaker 6 of 6
Yonatan Stelzer, Weizmann Institute of Science, Israel
Short Talk: Parent- and Sex-Specific DNA Methylation Dynamics during Mouse Development


Monday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Monday, March 26 | 7:30PM - 10:00PM
Poster Session 3
Room: Sea to Sky A


Tuesday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Tuesday, March 27 | 7:30AM - 8:00AM
Poster Setup
Room: Sea to Sky A


Tuesday, March 27 | 8:00AM - 5:00PM
Poster Viewing
Room: Sea to Sky A


Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
Room: Sea to Sky C

Speaker 1 of 9
* Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany

Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
Room: Sea to Sky C

Speaker 2 of 9
* Jane A. Skok, New York University School of Medicine, USA

Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
Room: Sea to Sky C

Speaker 3 of 9
Karen L. Reddy, Johns Hopkins University, USA
The Nuclear Lamina and the Shifting Shape of Epigenomes

Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
Room: Sea to Sky C

Speaker 4 of 9
Bas van Steensel, Netherlands Cancer Institute, Netherlands
Mechanisms of Gene Regulation in Lamina-Associated Domains.

Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
Room: Sea to Sky C


Coffee Break

Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
Room: Sea to Sky C

Speaker 6 of 9
Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
Histone H3K9me Mediates Heterochromatin Sequestration and Stabilizes Repeat Elements with BRCA1

Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
Room: Sea to Sky C

Speaker 7 of 9
Giacomo Cavalli, Institute of Human Genetics, France
Polycomb Proteins and 3D Genome Folding in the Epigenetic Regulation of Development

Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
Room: Sea to Sky C

Speaker 8 of 9
Robert Johnston, Johns Hopkins University, USA
Short Talk: Pairing TADs (PairiTs) Drive Homologous Chromosomes Together to Promote Interchromosomal Gene Regulation

Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
Room: Sea to Sky C

Speaker 9 of 9
Wei Xie, Tsinghua University, China
Short Talk: Conservation and Divergence of Chromatin Reprogramming in Early Mammalian Development

Tuesday, March 27 | 8:00AM - 11:00AM
Disease
This session is from Gene Control
Room: Sea to Sky B

Speaker 1 of 9
* Cheryl Arrowsmith, University of Toronto, Canada


Tuesday, March 27 | 8:00AM - 11:00AM
Disease
This session is from Gene Control
Room: Sea to Sky B

Speaker 2 of 9
* Richard A. Young, Whitehead Institute for Biomedical Research, USA


Tuesday, March 27 | 8:00AM - 11:00AM
Disease
This session is from Gene Control
Room: Sea to Sky B

Speaker 3 of 9
Peter C. Scacheri, Case Western Reserve University, USA
Mechanisms of Aberrant Enhancer Activation in Cancer


Tuesday, March 27 | 8:00AM - 11:00AM
Disease
This session is from Gene Control
Room: Sea to Sky B

Speaker 4 of 9
Manolis Kellis, Massachusetts Institute of Technology, Broad Institute, USA
Functional Dissection of Disease-Associated Variation


Tuesday, March 27 | 8:00AM - 11:00AM
Disease
This session is from Gene Control
Room: Sea to Sky B


Coffee Break


Tuesday, March 27 | 8:00AM - 11:00AM
Disease
This session is from Gene Control
Room: Sea to Sky B

Speaker 6 of 9
Matthias Merkenschlager, Imperial College London, UK
Cohesin Links Inflammation and Cancer


Tuesday, March 27 | 8:00AM - 11:00AM
Disease
This session is from Gene Control
Room: Sea to Sky B

Speaker 7 of 9
Chao Lu, Columbia University, USA
Short Talk: Reprogramming of Chromatin Organization by Cancer-Associated Histone H3 Mutations


Tuesday, March 27 | 8:00AM - 11:00AM
Disease
This session is from Gene Control
Room: Sea to Sky B

Speaker 8 of 9
Michele Gabriele, University of Milan, European Institute of Oncology, Italy
Short Talk: YY1 Haploinsufficiency Disrupts Histone Acetylation in Gabriele-De Vries Neurodevelopmental Syndrome


Tuesday, March 27 | 8:00AM - 11:00AM
Disease
This session is from Gene Control
Room: Sea to Sky B

Speaker 9 of 9
Jesse M. Engreitz, Harvard University and Broad Institute, USA
Short Talk: Principles of Enhancer Function from Thousands of CRISPR Perturbations


Tuesday, March 27 | 11:15AM - 12:00PM
Lunch
Room: Sea to Sky A


Tuesday, March 27 | 12:00PM - 2:30PM
Poster Session 4
Room: Sea to Sky A


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
This session is from Gene Control
Room: Sea to Sky B

Speaker 1 of 9
* Manolis Kellis, Massachusetts Institute of Technology, Broad Institute, USA


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
This session is from Gene Control
Room: Sea to Sky B

Speaker 2 of 9
* Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
This session is from Gene Control
Room: Sea to Sky B

Speaker 3 of 9
Zuzana Tothova, Dana-Farber Cancer Institute, USA
STAG2 Mutations Alter Cohesin Ring Structure and Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
This session is from Gene Control
Room: Sea to Sky B

Speaker 4 of 9
Damien Downes, University of Oxford, UK
Systematic Dissection of GWAS loci using Chromatin Conformation and NG Sequencing Approaches


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
This session is from Gene Control
Room: Sea to Sky B

Speaker 5 of 9
Elliott C. Ferris, University of Utah, USA
Convergent Patterns of Accelerated Evolution in Hibernating Mammals May Elucidate New Regulatory Mechanisms Shaping Human Metabolic Disease


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
This session is from Gene Control
Room: Sea to Sky B

Speaker 6 of 9
Nicholas C. Gomez, Rockefeller University, USA
Stem Cell Reprogramming during Oncogenesis and Development


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
This session is from Gene Control
Room: Sea to Sky B

Speaker 7 of 9
Kai Ge, NIDDK, National Institutes of Health, USA
Enhancer Epigenomic Regulation in Differentiation, Development and Cancer


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
This session is from Gene Control
Room: Sea to Sky B

Speaker 8 of 9
Debora R. Sobreira, University of Chicago, USA
Obesity-Associated Variants within FTO Are Functionally Connected to the Coordinated Expression of IRX3 and IRX5 in Brain and Adipose Tissue


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
This session is from Gene Control
Room: Sea to Sky B

Speaker 9 of 9
Rajesh C. Rao, University of Michigan, USA
Wdr5 Acts as a Temporal Rheostat to Control Retinal Neuroectoderm Versus Mesoderm Fate Choice


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
Room: Sea to Sky C

Speaker 1 of 8
* Geoffrey Fudenberg, University of California, San Francisco, USA

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
Room: Sea to Sky C

Speaker 2 of 8
* Marc A. Marti-Renom, CNAG-CRG, Spain

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
Room: Sea to Sky C

Speaker 3 of 8
Kristin Abramo, University of Massachusetts Medical School, USA
Building an Interphase Nucleus

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
Room: Sea to Sky C

Speaker 4 of 8
Annaelle Brunet, University of Oslo, Norway
Lamina-Associated Domains as Tuning Actors Configuring the Mechanical Constraints of the Chromatin Domain at Nuclear Periphery

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
Room: Sea to Sky C

Speaker 5 of 8
Nick Gilbert, University of Edinburgh, UK
Chromatin-Associated RNA Recycling by XRN2 Regulates Transcription and Chromosome Structure

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
Room: Sea to Sky C

Speaker 6 of 8
Kohta Ikegami, University of Chicago, USA
Phospho-Lamin A Binding at Enhancers Coordinates Nuclear Envelope Breakdown with Mitotic Transcriptional Quiescence

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
Room: Sea to Sky C

Speaker 7 of 8
Michele Di Pierro, Rice University, USA
De Novo Prediction of Human Chromosome Structures: Epigenetic Marking Patterns Encode Genome Architecture

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
Room: Sea to Sky C

Speaker 8 of 8
Jie Liang, University of Illinois at Chicago, USA
Deep Sampling to Reconstruct Large 3D Ensembles of Chromatin Chains from 2D Heatmaps of Captured Conformations

Tuesday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Tuesday, March 27 | 5:00PM - 6:45PM
Physical Modeling of Chromatin and Chromosomes
Room: Sea to Sky C

Speaker 1 of 4
* William J. Greenleaf, Stanford University, USA

Tuesday, March 27 | 5:00PM - 6:45PM
Physical Modeling of Chromatin and Chromosomes
Room: Sea to Sky C

Speaker 2 of 4
William Stafford Noble, University of Washington, USA
Modeling the 3D Architecture of the Genome

Tuesday, March 27 | 5:00PM - 6:45PM
Physical Modeling of Chromatin and Chromosomes
Room: Sea to Sky C

Speaker 3 of 4
Leonid Mirny, Massachusetts Institute of Technology, USA
Biophysical Models of Chromatin (re)Organization

Tuesday, March 27 | 5:00PM - 6:45PM
Physical Modeling of Chromatin and Chromosomes
Room: Sea to Sky C

Speaker 4 of 4
Marc A. Marti-Renom, CNAG-CRG, Spain
Structure Determination of Genomes and Genomic Domains by Satisfaction of Spatial Restraints

Tuesday, March 27 | 5:00PM - 6:45PM
Therapeutics
This session is from Gene Control
Room: Sea to Sky B

Speaker 1 of 5
* Leonard I. Zon, HHMI/Boston Children's Hospital, USA


Tuesday, March 27 | 5:00PM - 6:45PM
Therapeutics
This session is from Gene Control
Room: Sea to Sky B

Speaker 2 of 5
* Zuzana Tothova, Dana-Farber Cancer Institute, USA


Tuesday, March 27 | 5:00PM - 6:45PM
Therapeutics
This session is from Gene Control
Room: Sea to Sky B

Speaker 3 of 5
James E. Bradner, Novartis Institutes for BioMedical Research, USA
Transcription and Drug Discovery


Tuesday, March 27 | 5:00PM - 6:45PM
Therapeutics
This session is from Gene Control
Room: Sea to Sky B

Speaker 4 of 5
Cheryl Arrowsmith, University of Toronto, Canada
Probing the Epigenome using Chemical Biology


Tuesday, March 27 | 5:00PM - 6:45PM
Therapeutics
This session is from Gene Control
Room: Sea to Sky B

Speaker 5 of 5
Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA
Mutations in Epigenetic Regulators in the Biology and Therapy of Myeloid Malignancies


Tuesday, March 27 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Sea to Sky C


Tuesday, March 27 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Gene Control
Room: Sea to Sky B


Tuesday, March 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Tuesday, March 27 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Tuesday, March 27 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Wednesday, March 28 | 10:24AM - 10:24AM
Departure


*Session Chair.