Web Desc
Gene Control in Development and Disease
joint with Chromatin Architecture and Chromosome Organization
Organizer(s): Richard A. Young, Joanna Wysocka and Phillip A. Sharp
Date: March 23 - 27, 2018
Location: Whistler Conference Centre, Whistler, BC, Canada
Sponsored by Novartis Institutes for BioMedical Research
For important information on the coronavirus, please click here
Summary of Meeting:
Proper control of gene expression is important for all fundamental cellular and organismal processes. With advancements in technology and genetics, researchers are now able to use a combination of genetic, biochemical and computational methods to investigate gene control in healthy cells, as well as to discern what happens when these controls go awry in disease. Learning how gene expression programs are regulated is essential to understanding the control of cell state and its impact on disease development. Multiple levels of gene regulation including basic transcriptional controls, enhancers, epigenetics and the role of phase separation in transcriptional control will be addressed. The goal of this conference is to share new insights into gene control in health and disease and to discuss advances that are being made in disease therapy based on gene control therapeutics.
Scholarship Deadline: November 28 2017
Discounted Abstract Deadline: November 28 2017
Abstract Deadline: December 20 2017
Discounted Registration Deadline: January 17 2018
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Novartis Institutes for BioMedical Research
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, March 23 | 4:00PM - 8:00PM
Arrival and Registration
Room: Grand Foyer


Friday, March 23 | 6:00PM - 8:00PM
Welcome Mixer
Room: Grand Foyer
No registration fees are used to fund alcohol served at this function.

Saturday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Saturday, March 24 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky B

Speaker 1 of 4
* Joanna Wysocka, Stanford University, USA

Saturday, March 24 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky B

Speaker 2 of 4
* Phillip A. Sharp, Massachusetts Institute of Technology, USA

Saturday, March 24 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky B

Speaker 3 of 4
* Richard A. Young, Whitehead Institute for Biomedical Research, USA

Saturday, March 24 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky B

Speaker 4 of 4
Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Unexpected Activities of RNA-Guided CRISPR Enzymes

Saturday, March 24 | 9:00AM - 11:30AM
Basics
Room: Sea to Sky B

Speaker 1 of 7
* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA

Saturday, March 24 | 9:00AM - 11:30AM
Basics
Room: Sea to Sky B

Speaker 2 of 7
Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany
Integrated Structural Biology of Gene Transcription

Saturday, March 24 | 9:00AM - 11:30AM
Basics
Room: Sea to Sky B


Coffee Break

Saturday, March 24 | 9:00AM - 11:30AM
Basics
Room: Sea to Sky B

Speaker 4 of 7
Karen Adelman, Harvard Medical School, USA
Pause Control in Development and Disease

Saturday, March 24 | 9:00AM - 11:30AM
Basics
Room: Sea to Sky B

Speaker 5 of 7
Ronald M. Evans, HHMI/The Salk Institute, USA
Vitamin D and Dysregulated Transcription

Saturday, March 24 | 9:00AM - 11:30AM
Basics
Room: Sea to Sky B

Speaker 6 of 7
Xiong Ji, Peking University, China
Short Talk: RNAPII Elimination Reveals Transcriptional-Dependent Three-Dimensional Chromatin Landscape

Saturday, March 24 | 9:00AM - 11:30AM
Basics
Room: Sea to Sky B

Speaker 7 of 7
Diego Villar Lozano, University of Cambridge, UK
Short Talk: The Gene Expression Consequences of Mammalian Regulatory Evolution

Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 1 of 8
* Wendy A. Bickmore, University of Edinburgh, UK


Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 2 of 8
* William Stafford Noble, University of Washington, USA


Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 3 of 8
Carlo Vermeulen, Hubrecht Institute, Netherlands
Locus-Specific Enhancer Hubs and Architectural Loop Collisions Uncovered from Single Allele DNA Topologies


Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
This session is from Chromatin Architecture
Room: Sea to Sky C


Coffee Break


Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 5 of 8
Peter Fraser, Florida State University, USA
Chromosome Architecture Dynamics Using Single Cell HiC


Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 6 of 8
Suzana Hadjur, University College London, UK
Role of Cohesin Complex Diversity in Genome Organization and Cell Fate Determination


Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 7 of 8
Maciej Piotr Zaczek, Institute of Molecular Pathology, Austria
Short Talk: CTCF Constrains Cohesin Translocation along DNA


Saturday, March 24 | 9:00AM - 11:30AM
Chromosome Architecture
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 8 of 8
Elphège P. Nora, University of California San Francisco, USA
Short Talk: Dissecting the Molecular Connection between CTCF and Cohesin


Saturday, March 24 | 11:30AM - 5:00PM
On Own for Lunch


Saturday, March 24 | 11:30AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Saturday, March 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
Room: Sea to Sky B

Speaker 1 of 9
* Karen Adelman, Harvard Medical School, USA

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
Room: Sea to Sky B

Speaker 2 of 9
* Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
Room: Sea to Sky B

Speaker 3 of 9
Richard G. Jenner, University College London, UK
RNA Antagonizes the Interaction of PRC2 and Other Epigenetic Modifiers with Chromatin

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
Room: Sea to Sky B

Speaker 4 of 9
Natalia B. Ivanova, Yale University School of Medicine, USA
Chromatin-Associated Factors Dppa2 and Dppa4 Guide Epigenetic Remodeling during Cellular Reprogramming

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
Room: Sea to Sky B

Speaker 5 of 9
Ido Sagi, Hebrew University of Jerusalem, Israel
Studying Haploidy and Parental Imprinting in Human Pluripotent Stem Cells

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
Room: Sea to Sky B

Speaker 6 of 9
Aydan Bulut-Karslioglu, University of California, San Francisco, USA
Chd1-Mediated Repair of Physiological DNA Breaks Sustains Hypertranscription and Proliferation of ES Cells

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
Room: Sea to Sky B

Speaker 7 of 9
Ruben Esse, Boston University, USA
DOT1L in Enhancer Regulation

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
Room: Sea to Sky B

Speaker 8 of 9
Sudhir Thakurela, Harvard University, USA
Genetic Determinants and Epigenetic Effects of Pioneer Factor Occupancy during Development

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: Transcription and Development
Room: Sea to Sky B

Speaker 9 of 9
Elodie Emilie Thierion, University of Cambridge, UK
Gene Regulation Dynamics and Evolution in Somites


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 1 of 9
* Job Dekker, University of Massachusetts Medical School, USA


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 2 of 9
* Thoru Pederson, University of Massachusetts Medical School, USA
CRISPR Barcoding Reveals Changes in Interphase Chromosome Conformation and Dynamics in Human Cells


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 3 of 9
Josef Redolfi, Friedrich Miescher Institute for Biomedical Research, Switzerland
Crosslinking- and Ligation-Free Detection of Chromosomal Interactions using DamID and Physical Modeling


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 4 of 9
Kerstin Bystricky, University of Toulouse, France
Chromatin Dynamics in Real Time and at Nanoscale Resolution Reveal Transcription-Dependent Long-Range Correlation


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 5 of 9
Saumya Agrawal, RIKEN, Yokohama Campus, Japan
Association between Three-Dimensional Localization and Function of Long Noncoding RNAs


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 6 of 9
Sofia Quinodoz, California Institute of Technology, USA
Higher-Order Inter-Chromosomal Hubs Shape 3-Dimensional Genome Organization in the Nucleus


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 7 of 9
Valerio Orlando, King Abdullah University of Science and Technology, Saudi Arabia
Ago1 in Association with NEAT1 lncRNA Contributes to Nuclear and 3D Chromatin Architecture in Human Cells


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 8 of 9
Alice Sherrard, University of Bristol, UK
Imaging Chromatin Dynamics Reveals a Novel Mechanism for Nuclear Organization after Cell Division


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 1: 4DN
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 9 of 9
Marlies E. Oomen, University of Massachusetts Medical School, USA
Cell Cycle Dynamics of CTCF Binding and its Relation to Chromosome Organization


Saturday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Saturday, March 24 | 5:00PM - 7:00PM
Control Elements (Joint)
Room: Sea to Sky B/C

Speaker 1 of 6
* Bing Ren, Ludwig Institute for Cancer Research, USA

Saturday, March 24 | 5:00PM - 7:00PM
Control Elements (Joint)
Room: Sea to Sky B/C

Speaker 2 of 6
* Mikhail Spivakov, Babraham Institute, UK

Saturday, March 24 | 5:00PM - 7:00PM
Control Elements (Joint)
Room: Sea to Sky B/C

Speaker 3 of 6
Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany
Functional Insights into Genome Topology and Enhancer Function during Embryonic Development

Saturday, March 24 | 5:00PM - 7:00PM
Control Elements (Joint)
Room: Sea to Sky B/C

Speaker 4 of 6
Joanna Wysocka, Stanford University, USA
Enhancers in Development

Saturday, March 24 | 5:00PM - 7:00PM
Control Elements (Joint)
Room: Sea to Sky B/C

Speaker 5 of 6
Rajat Gupta, Massachusetts General Hospital, USA
Short Talk: A Genetic Variant Associated with Five Vascular Diseases Distally Regulates Gene Expression via Long-Range Enhancer Interactions

Saturday, March 24 | 5:00PM - 7:00PM
Control Elements (Joint)
Room: Sea to Sky B/C

Speaker 6 of 6
Jeff Alexander, University of California, San Francisco, USA
Short Talk: Live-Cell Imaging Reveals Enhancer-Dependent Sox2 Transcription Is Not Associated with Enhancer Proximity

Saturday, March 24 | 7:00PM - 8:15PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Saturday, March 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A


Sunday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 1 of 8
* Stavros Lomvardas, Columbia University, USA

Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 2 of 8
* Suzana Hadjur, University College London, UK

Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 3 of 8
Juanma Vaquerizas, Max Planck Institute for Molecular Biomedicine, Germany
Chromatin Architecture during Early Development

Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 4 of 8
Bing Ren, Ludwig Institute for Cancer Research, USA
Regulation of Lineage-Specific Chromatin Organization at Enhancers


Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C


Coffee Break

Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 6 of 8
Wendy A. Bickmore, University of Edinburgh, UK
The Remote Control of Gene Expression

Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 7 of 8
Edda G. Schulz, Max Planck Institute for Molecular Genetics, Germany
Two Coupled Feedback Loops Explain Random Mono-Allelic Xist Upregulation at the Onset of X-Chromosome Inactivation

Sunday, March 25 | 8:00AM - 11:00AM
Genome Structure (Joint)
Room: Sea to Sky B/C

Speaker 8 of 8
Julie Ahringer, University of Cambridge, UK
Short Talk: ARC-C for Genome-Wide Analysis of Regulatory Element Interactions at High Resolution

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 1 of 20
* Edith Heard, European Molecular Biology Laboratory, Germany

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 2 of 20
* Richard A. Young, Whitehead Institute for Biomedical Research, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 3 of 20
Sharon Ahmad, Journal of Cell Science, UK

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 4 of 20
Marie Bao, Cell Press, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 5 of 20
Katherine Brown, Company of Biologists, UK

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 6 of 20
Melina Casadio, Rockefeller University Press, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 7 of 20
Alex Eccleston, Nature, UK, UK

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 8 of 20
Markus Elsner, Nature Biotechnology, Germany

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 9 of 20
Tiago Faial, Nature Genetics, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 10 of 20
Sarah Geisler, Cell, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 11 of 20
Di Jiang, PLOS Biology, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 12 of 20
Steve Mao, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 13 of 20
Carolina Perdigoto, Nature Communications, UK

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 14 of 20
Nicole Rusk, Nature Methods, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 15 of 20
Rupa Sarkar, Lancet Digital Health, UK

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 16 of 20
Esther Schnapp, European Molecular Biology Organization, Germany

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 17 of 20
Julie Sollier, Developmental Cell, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 18 of 20
Anke Sparmann, Nature Structural and Molecular Biology, UK

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 19 of 20
Ruth Zearfoss, Cell Press, USA

Sunday, March 25 | 11:00AM - 12:00PM
Meet the Editors Panel (Joint)
Room: Sea to Sky A

Speaker 20 of 20
Eytan Zlotorynski, Nature Reviews Molecular Cell Biology, UK

Sunday, March 25 | 11:00AM - 5:00PM
On Own for Lunch


Sunday, March 25 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Sunday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Sunday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Sunday, March 25 | 5:00PM - 7:00PM
Epigenetics
Room: Sea to Sky B

Speaker 1 of 6
* Geeta J. Narlikar, University of California, San Francisco, USA

Sunday, March 25 | 5:00PM - 7:00PM
Epigenetics
Room: Sea to Sky B

Speaker 2 of 6
* Joseph R. Ecker, The Salk Institute for Biological Studies, USA

Sunday, March 25 | 5:00PM - 7:00PM
Epigenetics
Room: Sea to Sky B

Speaker 3 of 6
Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Epigenetic Pathways Regulating Cell Fate

Sunday, March 25 | 5:00PM - 7:00PM
Epigenetics
Room: Sea to Sky B

Speaker 4 of 6
Oliver J. Rando, University of Massachusetts Medical School, USA
Small RNA Trafficking during Sperm Epididymal Maturation Is Essential for Early Development in Mammals

Sunday, March 25 | 5:00PM - 7:00PM
Epigenetics
Room: Sea to Sky B

Speaker 5 of 6
Edith Heard, European Molecular Biology Laboratory, Germany

Developmental Dynamics of X-Chromosome Structure


Sunday, March 25 | 5:00PM - 7:00PM
Epigenetics
Room: Sea to Sky B

Speaker 6 of 6
Zachary Hugh Harvey, Stanford University, USA
Short Talk: A Prion That Mediates Meiotic Inheritances of Activated Chromatin States

Sunday, March 25 | 5:00PM - 7:00PM
Spatio-Temporal Dynamics of Chromatin
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 1 of 6
* Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany


Sunday, March 25 | 5:00PM - 7:00PM
Spatio-Temporal Dynamics of Chromatin
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 2 of 6
* Juanma Vaquerizas, Max Planck Institute for Molecular Biomedicine, Germany


Sunday, March 25 | 5:00PM - 7:00PM
Spatio-Temporal Dynamics of Chromatin
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 3 of 6
Stavros Lomvardas, Columbia University, USA
Interchromosomal Interactions Regulate Singular Olfactory Receptor Choice


Sunday, March 25 | 5:00PM - 7:00PM
Spatio-Temporal Dynamics of Chromatin
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 4 of 6
Victor G. Corces, Emory University School of Medicine, USA
Mechanisms of Transgenerational Inheritance


Sunday, March 25 | 5:00PM - 7:00PM
Spatio-Temporal Dynamics of Chromatin
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 5 of 6
Amos Tanay, Weizmann Institute, Israel
Single Cell Approaches in Epigenomics and 3D Chromosome Organization


Sunday, March 25 | 5:00PM - 7:00PM
Spatio-Temporal Dynamics of Chromatin
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 6 of 6
Yong Hoon Kim, University of Pennsylvania School of Medicine, USA
Short Talk: Rev-erb alpha Dynamically Modulates Chromatin Looping to Control Circadian Gene Transcription


Sunday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Sunday, March 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Monday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Monday, March 26 | 8:00AM - 11:30AM
New Models
Room: Sea to Sky B

Speaker 1 of 10
* Magdalena D. Zernicka-Goetz, Caltech and University of Cambridge, UK

Monday, March 26 | 8:00AM - 11:30AM
New Models
Room: Sea to Sky B

Speaker 2 of 10
* Yonatan Stelzer, Weizmann Institute of Science, Israel

Monday, March 26 | 8:00AM - 11:30AM
New Models
Room: Sea to Sky B

Speaker 3 of 10
Phillip A. Sharp, Massachusetts Institute of Technology, USA
Phase Separation in Transcription Control

Monday, March 26 | 8:00AM - 11:30AM
New Models
Room: Sea to Sky B

Speaker 4 of 10
Ibrahim Cissé, Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Live Mammalian Cells

Monday, March 26 | 8:00AM - 11:30AM
New Models
Room: Sea to Sky B


Coffee Break

Monday, March 26 | 8:00AM - 11:30AM
New Models
Room: Sea to Sky B

Speaker 6 of 10
Geeta J. Narlikar, University of California, San Francisco, USA
Phase-Separation in Heterochromatin Formation

Monday, March 26 | 8:00AM - 11:30AM
New Models
Room: Sea to Sky B

Speaker 7 of 10
Ankur Jain, University of California, San Francisco, USA
RNA Phase Separation and Neurodegenerative Disease

Monday, March 26 | 8:00AM - 11:30AM
New Models
Room: Sea to Sky B

Speaker 8 of 10
Sheila Teves, University of California, Berkeley, USA
Short Talk: A Stable Mode of Bookmarking by TBP Recruits RNA Polymerase II to Mitotic Chromosomes

Monday, March 26 | 8:00AM - 11:30AM
New Models
Room: Sea to Sky B

Speaker 9 of 10
Mounia Lagha, Centre National de la Recherche Scientifique, France
Short Talk: Zelda and Transcriptional Memory in Drosophila Embryos


Monday, March 26 | 8:00AM - 11:30AM
New Models
Room: Sea to Sky B

Speaker 10 of 10
Yuelin Song, Massachusetts Institute of Technology, USA
Short Talk: Dynamic DNA Methylation Heterogeneity at Super-Enhancers in Single-Cells

Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 1 of 10
* Karen L. Reddy, Johns Hopkins University, USA


Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 2 of 10
* Leonid Mirny, Massachusetts Institute of Technology, USA


Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 3 of 10
Jane A. Skok, New York University School of Medicine, USA
The Mechanisms Underlying the Impact of MMSET Overexpression on Gene Regulation in Multiple Myeloma


Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 4 of 10
Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Genome Architecture Mapping: Exploring Mechanisms of 3D Chromatin Folding in Rare Cell Types


Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
This session is from Chromatin Architecture
Room: Sea to Sky C


Coffee Break


Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 6 of 10
Mikhail Spivakov, Babraham Institute, UK
Mapping Genomic Regulatory Architecture and Interpreting Non-coding Variation with Promoter Capture Hi-C


Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 7 of 10
Kevin G. Monahan, Columbia University, USA
Short Talk: Ldb1 Is Required for the Formation of a Multi-Chromosomal Enhancer Hub that Governs Singular Olfactory Receptor Transcription


Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 8 of 10
Alistair Boettiger, Stanford University, USA
Short Talk: Nanoscale Visualization of cis-Regulation in Development using ORCA


Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 9 of 10
Jean J. Gautier, Columbia University, College of Physicians and Surgeons, USA
Short Talk: Nuclear Actin Polymerization Drives DNA Double-Strand Break Mobility and Clustering for Homology-Directed Repair


Monday, March 26 | 8:00AM - 11:15AM
Chromatin Architecture, Development and Disease
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 10 of 10
Rani E. George, Dana-Farber Cancer Institute, USA
Short Talk: The CTCF Paralog BORIS Promotes Novel Chromatin Regulatory Interactions in Cancer Cells


Monday, March 26 | 11:30AM - 5:00PM
On Own for Lunch


Monday, March 26 | 11:30AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Monday, March 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Monday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Monday, March 26 | 5:00PM - 7:00PM
Development
Room: Sea to Sky B

Speaker 1 of 6
* Natalia B. Ivanova, Yale University School of Medicine, USA

Monday, March 26 | 5:00PM - 7:00PM
Development
Room: Sea to Sky B

Speaker 2 of 6
* Peter C. Scacheri, Case Western Reserve University, USA

Monday, March 26 | 5:00PM - 7:00PM
Development
Room: Sea to Sky B

Speaker 3 of 6
Eliezer Calo, Massachusetts Institute of Technology, USA
Tissue-Selective Effects of Nucleolar Stress and rDNA Damage in Developmental Disorders

Monday, March 26 | 5:00PM - 7:00PM
Development
Room: Sea to Sky B

Speaker 4 of 6
Magdalena D. Zernicka-Goetz, Caltech and University of Cambridge, UK
Building the Mammalian Embryo in vivo and in vitro

Monday, March 26 | 5:00PM - 7:00PM
Development
Room: Sea to Sky B

Speaker 5 of 6
Joseph R. Ecker, The Salk Institute for Biological Studies, USA
Single Cell Methylomes Reveal Neuronal Populations and Regulatory Elements in the Mammalian Brain

Monday, March 26 | 5:00PM - 7:00PM
Development
Room: Sea to Sky B

Speaker 6 of 6
Yonatan Stelzer, Weizmann Institute of Science, Israel
Short Talk: Parent- and Sex-Specific DNA Methylation Dynamics during Mouse Development

Monday, March 26 | 5:00PM - 7:00PM
Integrating Chromatin States and Genome Architecture to Unde
rstand Genome Function
This session is from Chromatin Architecture

Room: Sea to Sky C

Speaker 1 of 6
* Giacomo Cavalli, Institute of Human Genetics, France


Monday, March 26 | 5:00PM - 7:00PM
Integrating Chromatin States and Genome Architecture to Unde
rstand Genome Function
This session is from Chromatin Architecture

Room: Sea to Sky C

Speaker 2 of 6
* Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland


Monday, March 26 | 5:00PM - 7:00PM
Integrating Chromatin States and Genome Architecture to Unde
rstand Genome Function
This session is from Chromatin Architecture

Room: Sea to Sky C

Speaker 3 of 6
John A. Stamatoyannopoulos, Altius Institute for Biomedical Sciences, USA
Transcriptional Circuitry and Regulatory Landscapes


Monday, March 26 | 5:00PM - 7:00PM
Integrating Chromatin States and Genome Architecture to Unde
rstand Genome Function
This session is from Chromatin Architecture

Room: Sea to Sky C

Speaker 4 of 6
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Phase Separation and Genome Architecture


Monday, March 26 | 5:00PM - 7:00PM
Integrating Chromatin States and Genome Architecture to Unde
rstand Genome Function
This session is from Chromatin Architecture

Room: Sea to Sky C

Speaker 5 of 6
William J. Greenleaf, Stanford University, USA
Understanding the Physical Genome


Monday, March 26 | 5:00PM - 7:00PM
Integrating Chromatin States and Genome Architecture to Unde
rstand Genome Function
This session is from Chromatin Architecture

Room: Sea to Sky C

Speaker 6 of 6
Jiao Sima, Florida State University, USA
Short Talk: CRISPR Dissection of a Replication Domain Reveals Discrete Internal cis Elements Regulating Replication Timing and Chromatin Compartment


Monday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Monday, March 26 | 7:30PM - 10:00PM
Poster Session 3
Room: Sea to Sky A


Tuesday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Tuesday, March 27 | 7:30AM - 8:00AM
Poster Setup
Room: Sea to Sky A


Tuesday, March 27 | 8:00AM - 5:00PM
Poster Viewing
Room: Sea to Sky A


Tuesday, March 27 | 8:00AM - 11:00AM
Disease
Room: Sea to Sky B

Speaker 1 of 9
* Cheryl Arrowsmith, University of Toronto, Canada

Tuesday, March 27 | 8:00AM - 11:00AM
Disease
Room: Sea to Sky B

Speaker 2 of 9
* Richard A. Young, Whitehead Institute for Biomedical Research, USA

Tuesday, March 27 | 8:00AM - 11:00AM
Disease
Room: Sea to Sky B

Speaker 3 of 9
Peter C. Scacheri, Case Western Reserve University, USA
Mechanisms of Aberrant Enhancer Activation in Cancer

Tuesday, March 27 | 8:00AM - 11:00AM
Disease
Room: Sea to Sky B

Speaker 4 of 9
Manolis Kellis, Massachusetts Institute of Technology, Broad Institute, USA
Functional Dissection of Disease-Associated Variation

Tuesday, March 27 | 8:00AM - 11:00AM
Disease
Room: Sea to Sky B


Coffee Break

Tuesday, March 27 | 8:00AM - 11:00AM
Disease
Room: Sea to Sky B

Speaker 6 of 9
Matthias Merkenschlager, Imperial College London, UK
Cohesin Links Inflammation and Cancer

Tuesday, March 27 | 8:00AM - 11:00AM
Disease
Room: Sea to Sky B

Speaker 7 of 9
Chao Lu, Columbia University, USA
Short Talk: Reprogramming of Chromatin Organization by Cancer-Associated Histone H3 Mutations

Tuesday, March 27 | 8:00AM - 11:00AM
Disease
Room: Sea to Sky B

Speaker 8 of 9
Michele Gabriele, University of Milan, European Institute of Oncology, Italy
Short Talk: YY1 Haploinsufficiency Disrupts Histone Acetylation in Gabriele-De Vries Neurodevelopmental Syndrome

Tuesday, March 27 | 8:00AM - 11:00AM
Disease
Room: Sea to Sky B

Speaker 9 of 9
Jesse M. Engreitz, Harvard University and Broad Institute, USA
Short Talk: Principles of Enhancer Function from Thousands of CRISPR Perturbations

Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 1 of 9
* Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany


Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 2 of 9
* Jane A. Skok, New York University School of Medicine, USA


Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 3 of 9
Karen L. Reddy, Johns Hopkins University, USA
The Nuclear Lamina and the Shifting Shape of Epigenomes


Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 4 of 9
Bas van Steensel, Netherlands Cancer Institute, Netherlands
Mechanisms of Gene Regulation in Lamina-Associated Domains.


Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
This session is from Chromatin Architecture
Room: Sea to Sky C


Coffee Break


Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 6 of 9
Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
Histone H3K9me Mediates Heterochromatin Sequestration and Stabilizes Repeat Elements with BRCA1


Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 7 of 9
Giacomo Cavalli, Institute of Human Genetics, France
Polycomb Proteins and 3D Genome Folding in the Epigenetic Regulation of Development


Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 8 of 9
Robert Johnston, Johns Hopkins University, USA
Short Talk: Pairing TADs (PairiTs) Drive Homologous Chromosomes Together to Promote Interchromosomal Gene Regulation


Tuesday, March 27 | 8:00AM - 11:15AM
Chromatin Architecture and the Nuclear Positioning
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 9 of 9
Wei Xie, Tsinghua University, China
Short Talk: Conservation and Divergence of Chromatin Reprogramming in Early Mammalian Development


Tuesday, March 27 | 11:00AM - 12:00PM
Lunch
Room: Sea to Sky A


Tuesday, March 27 | 12:00PM - 2:30PM
Poster Session 4
Room: Sea to Sky A


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
Room: Sea to Sky B

Speaker 1 of 9
* Manolis Kellis, Massachusetts Institute of Technology, Broad Institute, USA

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
Room: Sea to Sky B

Speaker 2 of 9
* Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
Room: Sea to Sky B

Speaker 3 of 9
Zuzana Tothova, Dana-Farber Cancer Institute, USA
STAG2 Mutations Alter Cohesin Ring Structure and Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
Room: Sea to Sky B

Speaker 4 of 9
Damien Downes, University of Oxford, UK
Systematic Dissection of GWAS loci using Chromatin Conformation and NG Sequencing Approaches

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
Room: Sea to Sky B

Speaker 5 of 9
Elliott C. Ferris, University of Utah, USA
Convergent Patterns of Accelerated Evolution in Hibernating Mammals May Elucidate New Regulatory Mechanisms Shaping Human Metabolic Disease

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
Room: Sea to Sky B

Speaker 6 of 9
Nicholas C. Gomez, Rockefeller University, USA
Stem Cell Reprogramming during Oncogenesis and Development

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
Room: Sea to Sky B

Speaker 7 of 9
Kai Ge, NIDDK, National Institutes of Health, USA
Enhancer Epigenomic Regulation in Differentiation, Development and Cancer

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
Room: Sea to Sky B

Speaker 8 of 9
Debora R. Sobreira, University of Chicago, USA
Obesity-Associated Variants within FTO Are Functionally Connected to the Coordinated Expression of IRX3 and IRX5 in Brain and Adipose Tissue

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Disease Connections
Room: Sea to Sky B

Speaker 9 of 9
Rajesh C. Rao, University of Michigan, USA
Wdr5 Acts as a Temporal Rheostat to Control Retinal Neuroectoderm Versus Mesoderm Fate Choice

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 1 of 8
* Geoffrey Fudenberg, University of California, San Francisco, USA


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 2 of 8
* Marc A. Marti-Renom, CNAG-CRG, Spain


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 3 of 8
Kristin Abramo, University of Massachusetts Medical School, USA
Building an Interphase Nucleus


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 4 of 8
Annaelle Brunet, University of Oslo, Norway
Lamina-Associated Domains as Tuning Actors Configuring the Mechanical Constraints of the Chromatin Domain at Nuclear Periphery


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 5 of 8
Nick Gilbert, University of Edinburgh, UK
Chromatin-Associated RNA Recycling by XRN2 Regulates Transcription and Chromosome Structure


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 6 of 8
Kohta Ikegami, University of Chicago, USA
Phospho-Lamin A Binding at Enhancers Coordinates Nuclear Envelope Breakdown with Mitotic Transcriptional Quiescence


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 7 of 8
Michele Di Pierro, Rice University, USA
De Novo Prediction of Human Chromosome Structures: Epigenetic Marking Patterns Encode Genome Architecture


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 2: Modeling and Simulations
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 8 of 8
Jie Liang, University of Illinois at Chicago, USA
Deep Sampling to Reconstruct Large 3D Ensembles of Chromatin Chains from 2D Heatmaps of Captured Conformations


Tuesday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Tuesday, March 27 | 5:00PM - 6:45PM
Therapeutics
Room: Sea to Sky B

Speaker 1 of 5
* Leonard I. Zon, HHMI/Boston Children's Hospital, USA

Tuesday, March 27 | 5:00PM - 6:45PM
Therapeutics
Room: Sea to Sky B

Speaker 2 of 5
* Zuzana Tothova, Dana-Farber Cancer Institute, USA

Tuesday, March 27 | 5:00PM - 6:45PM
Therapeutics
Room: Sea to Sky B

Speaker 3 of 5
James E. Bradner, Novartis Institutes for BioMedical Research, USA
Transcription and Drug Discovery

Tuesday, March 27 | 5:00PM - 6:45PM
Therapeutics
Room: Sea to Sky B

Speaker 4 of 5
Cheryl Arrowsmith, University of Toronto, Canada
Probing the Epigenome using Chemical Biology

Tuesday, March 27 | 5:00PM - 6:45PM
Therapeutics
Room: Sea to Sky B

Speaker 5 of 5
Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA
Mutations in Epigenetic Regulators in the Biology and Therapy of Myeloid Malignancies

Tuesday, March 27 | 5:00PM - 6:45PM
Physical Modeling of Chromatin and Chromosomes
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 1 of 4
* William J. Greenleaf, Stanford University, USA


Tuesday, March 27 | 5:00PM - 6:45PM
Physical Modeling of Chromatin and Chromosomes
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 2 of 4
William Stafford Noble, University of Washington, USA
Modeling the 3D Architecture of the Genome


Tuesday, March 27 | 5:00PM - 6:45PM
Physical Modeling of Chromatin and Chromosomes
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 3 of 4
Leonid Mirny, Massachusetts Institute of Technology, USA
Biophysical Models of Chromatin (re)Organization


Tuesday, March 27 | 5:00PM - 6:45PM
Physical Modeling of Chromatin and Chromosomes
This session is from Chromatin Architecture
Room: Sea to Sky C

Speaker 4 of 4
Marc A. Marti-Renom, CNAG-CRG, Spain
Structure Determination of Genomes and Genomic Domains by Satisfaction of Spatial Restraints


Tuesday, March 27 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Sea to Sky B


Tuesday, March 27 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Chromatin Architecture
Room: Sea to Sky C


Tuesday, March 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Tuesday, March 27 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Tuesday, March 27 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Wednesday, March 28 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.