Web Desc
Tuberculosis: Translating Scientific Findings for Clinical and Public Health Impact
joint with HIV and Co-Infections: Pathogenesis, Inflammation and Persistence
Organizer(s): Graeme Meintjes, Eric J. Rubin and Sabine Ehrt
Date: April 15 - 19, 2018
Location: Fairmont Chateau Whistler, Whistler, BC, Canada
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
It is estimated that one-third of the world’s population is infected with tuberculosis, and each year 10 million people develop disease, with 1.5 million tuberculosis-related deaths. Global control efforts using currently available diagnostic, treatment and preventive tools are predicted to achieve only gradual reductions in global tuberculosis incidence. Critical factors impeding tuberculosis control are the ability of Mycobacterium tuberculosis to evade host-killing mechanisms and enter into a phenotypic state of persistence with risk of later reactivation, HIV co-infection which drives progression to disease, the emergence and transmission of drug-resistant strains, our limited understanding of the immune responses necessary to kill or effectively contain Mycobacterium tuberculosis and how to elicit these with a novel vaccine. To accelerate progress in TB control, deeper fundamental insights into the pathogen and pathogen-host interactions are required, and these then need to be translated into more effective tools at a public health level. Under the theme of translation, this conference brings together laboratory, clinical and epidemiological tuberculosis researchers to engage the key scientific questions in tuberculosis science including persistence, metabolic adaptation, immune evasion, prediction and early diagnosis of progression to disease, drug resistance, discovery of novel drug targets, and determinants of morbidity and mortality. This will allow for cross-talk between disciplines and triangulation of research findings from epidemiological and clinical studies and laboratory and animal models. The meeting explores what fundamental insights are needed to advance TB control and how fundamental insights can be translated for clinical and public health impact. For the first time, the meeting is held jointly with the Keystone Symposia’s “HIV and Co-Infections: Pathogenesis, Inflammation and Persistence” conference, which will facilitate discussion around HIV and tuberculosis co-infection and explore synergies in the respective fields.
Global Health Travel Award Deadline: November 14 2017
Scholarship Deadline: December 13 2017
Discounted Abstract Deadline: December 13 2017
Abstract Deadline: January 11 2018
Discounted Registration Deadline: February 15 2018
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Gates Foundation
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI138573-01
Funding for this conference was made possible (in part) by 1R13AI138573-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 15 | 4:00PM - 8:00PM
Arrival and Registration
Room: Macdonald Foyer


Sunday, April 15 | 6:00PM - 8:00PM
Welcome Mixer
Room: Macdonald Foyer
No registration fees are used to fund alcohol served at this function.

Monday, April 16 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac/Empress


Monday, April 16 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Macdonald Ballroom

Speaker 1 of 5
* Graeme Meintjes, University of Cape Town, South Africa

Monday, April 16 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Macdonald Ballroom

Speaker 2 of 5
* Irini Sereti, NIAID, National Institutes of Health, USA

Monday, April 16 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Macdonald Ballroom

Speaker 3 of 5
Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
New Insights into HIV Pathogenesis: Implications for Immunotherapeutic Strategies

Monday, April 16 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Macdonald Ballroom

Speaker 4 of 5
Gavin J. Churchyard, Aurum Institute NPC, South Africa
Translating TB Science to Impact the Epidemic

Monday, April 16 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Macdonald Ballroom


Coffee Break

Monday, April 16 | 9:50AM - 12:15PM
Prospects for Epidemic Control and the Scientific Insights R
equired

Room: Macdonald ABC

Speaker 1 of 8
* Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA

Monday, April 16 | 9:50AM - 12:15PM
Prospects for Epidemic Control and the Scientific Insights R
equired

Room: Macdonald ABC

Speaker 2 of 8
* Henry Charles Mwandumba, Liverpool School of Tropical Medicine, UK

Monday, April 16 | 9:50AM - 12:15PM
Prospects for Epidemic Control and the Scientific Insights R
equired

Room: Macdonald ABC

Speaker 3 of 8
Richard E. Chaisson, Johns Hopkins University, USA
Treatment of Latent TB for Epidemic Control

Monday, April 16 | 9:50AM - 12:15PM
Prospects for Epidemic Control and the Scientific Insights R
equired

Room: Macdonald ABC

Speaker 4 of 8
Mark Hatherill, University of Cape Town, South Africa
Translating Transcriptomic Insights into Clinical Tools

Monday, April 16 | 9:50AM - 12:15PM
Prospects for Epidemic Control and the Scientific Insights R
equired

Room: Macdonald ABC

Speaker 5 of 8
Carole D. Mitnick, Harvard Medical School, USA
(Re)Moving the Needle in Treatment for Rifampin-Resistant TB: The endTB Trial

Monday, April 16 | 9:50AM - 12:15PM
Prospects for Epidemic Control and the Scientific Insights R
equired

Room: Macdonald ABC

Speaker 6 of 8
Michael Gordon Whitfield, Stellenbosch University, South Africa
Short Talk: The Potential of Rifabutin for the Treatment of Rifampicin-Resistant Tuberculosis

Monday, April 16 | 9:50AM - 12:15PM
Prospects for Epidemic Control and the Scientific Insights R
equired

Room: Macdonald ABC

Speaker 7 of 8
Francesca Tomasi, Harvard T. H. Chan School of Public Health, USA
Short Talk: Small Molecule Inhibitors of Amino Acid Metabolism in Mycobacterium tuberculosis: A Model with Acivicin

Monday, April 16 | 9:50AM - 12:15PM
Prospects for Epidemic Control and the Scientific Insights R
equired

Room: Macdonald ABC

Speaker 8 of 8
Meera Gurumurthy, International Union Against Tuberculosis and Lung Disease, Singapore
Short Talk: Randomised Controlled trial of Pascolizumab (Anti-IL-4 Monoclonal Antibody) as an Adjunct to Standard TB Treatment

Monday, April 16 | 9:50AM - 12:00PM
Off to a Strong Start: Lessons from Acute HIV Infection
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 1 of 7
* Ann Duerr, Fred Hutchinson Cancer Research Center, USA


Monday, April 16 | 9:50AM - 12:00PM
Off to a Strong Start: Lessons from Acute HIV Infection
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 2 of 7
* Nicolas Chomont, Université de Montréal, Canada


Monday, April 16 | 9:50AM - 12:00PM
Off to a Strong Start: Lessons from Acute HIV Infection
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 3 of 7
Thumbi Ndung'u, University of KwaZulu-Natal, South Africa
Evidence of Transmission-Virulence Evolutionary Trade-Offs in the Spread of HIV-1 Subtypes


Monday, April 16 | 9:50AM - 12:00PM
Off to a Strong Start: Lessons from Acute HIV Infection
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 4 of 7
Julie Mitchell, Vaccine and Gene Therapy Institute, OHSU, USA
T Cell Responses in Acutely Infected Young Men in Thailand


Monday, April 16 | 9:50AM - 12:00PM
Off to a Strong Start: Lessons from Acute HIV Infection
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 5 of 7
John Frater, University of Oxford, UK
Predictors of Outcome in Primary HIV Infection


Monday, April 16 | 9:50AM - 12:00PM
Off to a Strong Start: Lessons from Acute HIV Infection
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 6 of 7
Elina El-Badry, Emory University, USA
Short Talk: Zambian Women Exhibit an Exacerbated Inflammatory Response to Early HIV Infection Compared to Men


Monday, April 16 | 9:50AM - 12:00PM
Off to a Strong Start: Lessons from Acute HIV Infection
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 7 of 7
Heeva Baharlou, Westmead Institute for Medical Research, Australia
Short Talk: HIV and the Colorectal Mucosa – Investigating the Early Interactions of HIV with Mucosal Target Cells in situ


Monday, April 16 | 12:15PM - 5:00PM
On Own for Lunch


Monday, April 16 | 12:15PM - 1:00PM
Poster Setup
Room: Frontenac/Empress


Monday, April 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Frontenac/Empress


Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: TB Vaccines
Room: Macdonald ABC

Speaker 1 of 10
* Cesar A. Boggiano, NIAID, National Institutes of Health, USA

Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: TB Vaccines
Room: Macdonald ABC

Speaker 2 of 10
* Willem A. Hanekom, Bill & Melinda Gates Foundation, USA
State of the TB Vaccine Field

Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: TB Vaccines
Room: Macdonald ABC

Speaker 3 of 10
Karen Lacourciere, NIAID, National Institutes of Health, USA
Funding Opportunities in TB Vaccine Research

Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: TB Vaccines
Room: Macdonald ABC

Speaker 4 of 10
Lakshmi Ramachandra, NIAID, National Institutes of Health, USA
Funding Opportunities in TB Vaccine Research

Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: TB Vaccines
Room: Macdonald ABC

Speaker 5 of 10
Tracey Day, Infectious Disease Research Institute, USA
Clinical Development of ID93+GLA-SE as a Prophylactic or Therapeutic Vaccine for Tuberculosis

Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: TB Vaccines
Room: Macdonald ABC

Speaker 6 of 10
Stephen C. De Rosa, University of Washington, Fred Hutchinson Cancer Research Center, USA
BCG Revaccination Significantly Boosts Circulating, Polyfunctional, Mtb-Specific CD4 T Cell Effector Responses in Young Adults with Latent TB Living in South India

Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: TB Vaccines
Room: Macdonald ABC

Speaker 7 of 10
Karin Dijkman, Biomedical Primate Research Centre, Netherlands
Local IL17A after Mucosal BCG Vaccination Associates with Protection from Infection and Disease in a Novel, Repeated Ultra-Low Dose TB Challenge Model in Rhesus Macaques

Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: TB Vaccines
Room: Macdonald ABC

Speaker 8 of 10
Ved Prakash Dwivedi, International Center for Genetic Engineering and Biotechnology, India
Mimicking Mycobacterium tuberculosis for the Immunization in the Lung thereby Generating Effective Vaccine in the Local Milieu

Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: TB Vaccines
Room: Macdonald ABC

Speaker 9 of 10
Sasha E. Larsen, Universty of Washington, USA
Therapeutic Immunizations Induce Control of Bacterial Burden and Increase Survival in a Preclinical Mouse Model of Mycobacterium tuberculosis

Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: TB Vaccines
Room: Macdonald ABC

Speaker 10 of 10
Elisa Nemes, University of Cape Town, South Africa
Prevention of Infection with Mycobacterium tuberculosis by H4:IC31® Vaccination or BCG Revaccination in Adolescents  

Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: Role of Metabolism and Inflammation in SIV/HIV P
athogenesis and Reservoirs
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 1 of 10
* Asier Sáez-Cirión, Institut Pasteur, France


Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: Role of Metabolism and Inflammation in SIV/HIV P
athogenesis and Reservoirs
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 2 of 10
* Michael A. Eller, National Institute of Allergy and Infectious Diseases, USA


Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: Role of Metabolism and Inflammation in SIV/HIV P
athogenesis and Reservoirs
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 3 of 10
Cristian Apetrei, University of Pittsburgh, USA
High Fat Diet Exacerbates SIV Pathogenesis in SIVsab Infection Models


Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: Role of Metabolism and Inflammation in SIV/HIV P
athogenesis and Reservoirs
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 4 of 10
Mohamed Abdel-Mohsen, Wistar Institute, USA
Plasma and Immunoglobulin G Galactosylation Associate with HIV Persistence During Antiretroviral Therapy


Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: Role of Metabolism and Inflammation in SIV/HIV P
athogenesis and Reservoirs
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 5 of 10
Livia Ramos Goes, Instituto Nacional de Cancer, Brazil
MAdCAM Costimulation in Presence of Retinoic Acid Promotes Viral Replication in Recently Activated Naïve CD4+ T Cells


Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: Role of Metabolism and Inflammation in SIV/HIV P
athogenesis and Reservoirs
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 6 of 10
Virginie W. Gautier, University College Dublin, Ireland
Targeting HIV Latency with Metabolic Cues


Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: Role of Metabolism and Inflammation in SIV/HIV P
athogenesis and Reservoirs
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 7 of 10
Sergei Nekhai, Howard University, USA
Upregulated Iron Metabolism Induces Intrinsic HIV-1 Restriction in Sickle Cell Disease


Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: Role of Metabolism and Inflammation in SIV/HIV P
athogenesis and Reservoirs
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 8 of 10
Sandra Milena Gonzalez Diaz, Universidad de Antioquia, Colombia
Active and Inactive Forms of Vitamin D Reduce the HIV-1 Infection of CD4+ T Cells in Vitro and Modulate their Activation Level


Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: Role of Metabolism and Inflammation in SIV/HIV P
athogenesis and Reservoirs
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 9 of 10
Emily Bowman, Ohio State University, USA
Altered Macrophage Phenotype in HIV Infection May Contribute to Vascular Inflammation


Monday, April 16 | 2:30PM - 4:30PM
Workshop 1: Role of Metabolism and Inflammation in SIV/HIV P
athogenesis and Reservoirs
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 10 of 10
Robert Blomgran, Linköping University, Sweden
HIV Interferes with The DC-T Cell Axis of Macrophage Activation by Shifting Mycobacterium tuberculosis-Specific CD4 T Cells into a Dysfunctional Tolerized Phenotype


Monday, April 16 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Monday, April 16 | 5:00PM - 7:00PM
Mycobacterium Tuberculosis and Host Evasion
Room: Macdonald ABC

Speaker 1 of 6
* Joel D. Ernst, University of California, San Francisco, USA

Monday, April 16 | 5:00PM - 7:00PM
Mycobacterium Tuberculosis and Host Evasion
Room: Macdonald ABC

Speaker 2 of 6
* Sarah M. Fortune, Harvard TH Chan School of Public Health, USA

Monday, April 16 | 5:00PM - 7:00PM
Mycobacterium Tuberculosis and Host Evasion
Room: Macdonald ABC

Speaker 3 of 6
JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Granuloma Dynamics in Tuberculosis

Monday, April 16 | 5:00PM - 7:00PM
Mycobacterium Tuberculosis and Host Evasion
Room: Macdonald ABC

Speaker 4 of 6
Robert A. Seder, NIAID, National Institutes of Health, USA
A Novel Approach to BCG Vaccination in the NHP Model

Monday, April 16 | 5:00PM - 7:00PM
Mycobacterium Tuberculosis and Host Evasion
Room: Macdonald ABC

Speaker 5 of 6
Jennifer Philips, Washington University School of Medicine, USA
Hijacking the Host – Molecular Interactions between Host and Pathogen

Monday, April 16 | 5:00PM - 7:00PM
Mycobacterium Tuberculosis and Host Evasion
Room: Macdonald ABC

Speaker 6 of 6
Samuel M. Behar, University of Massachusetts Medical School, USA
Short Talk: Decoy Antigens Elicit Immunodominant T Cell Responses that Fail to Recognize Infected Macrophages

Monday, April 16 | 5:00PM - 7:00PM
New and Old Players in Mucosal Immunity and their Role in HI
V/SIV Infection
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 1 of 6
* Barbara L. Shacklett, University of California, Davis, USA


Monday, April 16 | 5:00PM - 7:00PM
New and Old Players in Mucosal Immunity and their Role in HI
V/SIV Infection
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 2 of 6
* Karl Salzwedel, NIAID, National Institutes of Health, USA


Monday, April 16 | 5:00PM - 7:00PM
New and Old Players in Mucosal Immunity and their Role in HI
V/SIV Infection
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 3 of 6
Johan K. Sandberg, Karolinska Institute, Sweden
Role of MAIT Cells in Immune Defense and HIV Immunopathogenesis


Monday, April 16 | 5:00PM - 7:00PM
New and Old Players in Mucosal Immunity and their Role in HI
V/SIV Infection
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 4 of 6
Petronela Ancuta, Centre de Recherche de l'Universite de Montreal, Canada
HIV Persistence in Th17 Cells: Finding New Ways to Cure


Monday, April 16 | 5:00PM - 7:00PM
New and Old Players in Mucosal Immunity and their Role in HI
V/SIV Infection
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 5 of 6
Jason M. Brenchley, NIAID, National Institutes of Health, USA
Mechanisms Underlying Loss of ILCs in Progressive SIV Infection


Monday, April 16 | 5:00PM - 7:00PM
New and Old Players in Mucosal Immunity and their Role in HI
V/SIV Infection
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 6 of 6
Dominic Paquin Proulx, US Military HIV Research Program, USA
Short Talk: Permanent Loss of Regulatory Colonic CD4+ iNKT Cells in Early Acute HIV-1 Infection


Monday, April 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Frontenac/Empress
No registration fees are used to fund alcohol served at this function.

Monday, April 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Frontenac/Empress


Tuesday, April 17 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac/Empress


Tuesday, April 17 | 7:30AM - 8:00AM
Poster Setup
Room: Frontenac/Empress


Tuesday, April 17 | 8:00AM - 5:00PM
Poster Viewing
Room: Frontenac/Empress


Tuesday, April 17 | 8:00AM - 11:15AM
Drug Tolerance and Resistance
Room: Macdonald ABC

Speaker 1 of 9
* Sabine Ehrt, Weill Cornell Medical College, USA

Tuesday, April 17 | 8:00AM - 11:15AM
Drug Tolerance and Resistance
Room: Macdonald ABC

Speaker 2 of 9
* Christopher M. Sassetti, University of Massachusetts Medical School, USA

Tuesday, April 17 | 8:00AM - 11:15AM
Drug Tolerance and Resistance
Room: Macdonald ABC

Speaker 3 of 9
Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA
I Guess You're Just What I Needed – What Does it Mean to Be Essential?

Tuesday, April 17 | 8:00AM - 11:15AM
Drug Tolerance and Resistance
Room: Macdonald ABC

Speaker 4 of 9
Bree B. Aldridge, Tufts University, USA
Efficient Measurement and Analysis of High-Order Drug Interactions

Tuesday, April 17 | 8:00AM - 11:15AM
Drug Tolerance and Resistance
Room: Macdonald ABC


Coffee Break

Tuesday, April 17 | 8:00AM - 11:15AM
Drug Tolerance and Resistance
Room: Macdonald ABC

Speaker 6 of 9
Luiz Pedro Carvalho, Francis Crick Institute, UK
How to Make 'Resistance-Proof' Antibiotics?

Tuesday, April 17 | 8:00AM - 11:15AM
Drug Tolerance and Resistance
Room: Macdonald ABC

Speaker 7 of 9
Mark Ragheb, University of Washington, USA
Short Talk: Mfd Promotes Rapid Evolution of Antibiotic Resistance

Tuesday, April 17 | 8:00AM - 11:15AM
Drug Tolerance and Resistance
Room: Macdonald ABC

Speaker 8 of 9
Sarah M. Fortune, Harvard TH Chan School of Public Health, USA
Multi-Drug-Tolerant Mutants Identified through a Population GWAS

Tuesday, April 17 | 8:00AM - 11:15AM
Drug Tolerance and Resistance
Room: Macdonald ABC

Speaker 9 of 9
Bryan J. Berube, Infectious Disease Research Institute, USA
Short Talk: Dual Targeting of the M. tuberculosis Electron-Transport Chain Enhances Bacterial Killing and Limits Spontaneous Mutant Formation

Tuesday, April 17 | 8:00AM - 11:15AM
Innate Responses in HIV and SIV Infection: The Good, the Bad
and the Splendid
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 1 of 10
* Anthony L. Cunningham, Westmead Institute for Medical Research, Australia


Tuesday, April 17 | 8:00AM - 11:15AM
Innate Responses in HIV and SIV Infection: The Good, the Bad
and the Splendid
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 2 of 10
* R. Keith Reeves, Harvard Medical School, USA


Tuesday, April 17 | 8:00AM - 11:15AM
Innate Responses in HIV and SIV Infection: The Good, the Bad
and the Splendid
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 3 of 10
Marcus Altfeld, Heinrich-Pette-Institute, Germany
Innate Immune Responses in HIV-1: Mediators of Viral Control and Immune Activation


Tuesday, April 17 | 8:00AM - 11:15AM
Innate Responses in HIV and SIV Infection: The Good, the Bad
and the Splendid
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 4 of 10
Michaela Müller-Trutwin, Institut Pasteur, France
Innate Immune Responses in Non-Pathogenic SIV Infection


Tuesday, April 17 | 8:00AM - 11:15AM
Innate Responses in HIV and SIV Infection: The Good, the Bad
and the Splendid
This session is from HIV Pathogenesis

Room: Macdonald DEF


Coffee Break


Tuesday, April 17 | 8:00AM - 11:15AM
Innate Responses in HIV and SIV Infection: The Good, the Bad
and the Splendid
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 6 of 10
Teunis B.H. Geijtenbeek, University of Amsterdam, Netherlands
Innate Responses by Dendritic Cells in HIV Infection – A Role in Pathogenesis


Tuesday, April 17 | 8:00AM - 11:15AM
Innate Responses in HIV and SIV Infection: The Good, the Bad
and the Splendid
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 7 of 10
Tram N.Q. Pham, Institut de Recherches Cliniques de Montreal, Canada
Short Talk: Flt3L Treatment Reduces HIV Infection and Replication in Humanized Mice via a Plasmacytoid Dendritic Cell-Dependent Process


Tuesday, April 17 | 8:00AM - 11:15AM
Innate Responses in HIV and SIV Infection: The Good, the Bad
and the Splendid
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 8 of 10
Henrik N. Kloverpris, University of KwaZulu-Natal, South Africa
Short Talk: HIV-Infected Children Have Life-Long Depletion of all Circulating Innate Lymphoid Cells (ILCs) but Respond to Infection through Tissue-Resident ILCs


Tuesday, April 17 | 8:00AM - 11:15AM
Innate Responses in HIV and SIV Infection: The Good, the Bad
and the Splendid
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 9 of 10
Daniel Claiborne, Ragon Institute of MGH, MIT, and Harvard, USA
Short Talk: Integral Role of Monocytes in Immune Activation during HIV-1 Infection


Tuesday, April 17 | 8:00AM - 11:15AM
Innate Responses in HIV and SIV Infection: The Good, the Bad
and the Splendid
This session is from HIV Pathogenesis

Room: Macdonald DEF

Speaker 10 of 10
Ivona Pandrea, University of Pittsburgh, USA
Short Talk: Neutrophil Extracellular Trap (NET) Production in SIV-Infected Nonhuman Primates


Tuesday, April 17 | 11:15AM - 12:00PM
Lunch
Room: Frontenac/Empress


Tuesday, April 17 | 12:00PM - 2:30PM
Poster Session 2
Room: Frontenac/Empress


Tuesday, April 17 | 2:30PM - 4:30PM
Workshop 2: HIV, TB and Other Co-Infections (Joint)
Room: Macdonald Ballroom

Speaker 1 of 10
* Donald L. Sodora, Center for Infectious Disease Research, USA

Tuesday, April 17 | 2:30PM - 4:30PM
Workshop 2: HIV, TB and Other Co-Infections (Joint)
Room: Macdonald Ballroom

Speaker 2 of 10
* Shelby O'Connor, University of Wisconson-Madison, USA

Tuesday, April 17 | 2:30PM - 4:30PM
Workshop 2: HIV, TB and Other Co-Infections (Joint)
Room: Macdonald Ballroom

Speaker 3 of 10
Allison Nicole Bucsan, NIH, USA
Mtb/SIV Co-Infection Induces Differential T Cell Responses in Rhesus Macaques

Tuesday, April 17 | 2:30PM - 4:30PM
Workshop 2: HIV, TB and Other Co-Infections (Joint)
Room: Macdonald Ballroom

Speaker 4 of 10
Anna Kathleen Coussens, Walter and Eliza Hall Institute, Australia
GBPs in TB-HIV, A Double-Edge Sword in Prevention and Progression

Tuesday, April 17 | 2:30PM - 4:30PM
Workshop 2: HIV, TB and Other Co-Infections (Joint)
Room: Macdonald Ballroom

Speaker 5 of 10
Rabiah Fardoos, Africa Health Research Institute, South Africa
Profiling of HIV and CMV-Specific CD8+ T-Cells Isolated from HIV-Infected Human Lymphoid Tissue Display a Distinct Phenotype Compartmentalization

Tuesday, April 17 | 2:30PM - 4:30PM
Workshop 2: HIV, TB and Other Co-Infections (Joint)
Room: Macdonald Ballroom

Speaker 6 of 10
Collin Richard Diedrich, University of Pittsburgh, USA
SIVmac251 and Neutralizing CD4 T Cell Antibodies Induce Reactivation of Latent Tuberculosis Infection by Distinct Mechanisms

Tuesday, April 17 | 2:30PM - 4:30PM
Workshop 2: HIV, TB and Other Co-Infections (Joint)
Room: Macdonald Ballroom

Speaker 7 of 10
Amy Kathryn Dickey, Massachusetts General Hospital, Ragon Institute, USA
Slam Family Receptors May Act as Inhibitory Receptors in the Airways of HIV-Infected Individuals

Tuesday, April 17 | 2:30PM - 4:30PM
Workshop 2: HIV, TB and Other Co-Infections (Joint)
Room: Macdonald Ballroom

Speaker 8 of 10
Annapurna Vyakarnam, King's College London, UK
HIV Alters the Mtb-Specific Th17 Response in Latent TB

Tuesday, April 17 | 2:30PM - 4:30PM
Workshop 2: HIV, TB and Other Co-Infections (Joint)
Room: Macdonald Ballroom

Speaker 9 of 10
Joshua T. Mattila, University of Pittsburgh, USA
Type 3 Interferons Are Expressed in Tuberculous Granulomas and May Influence Signaling in Epithelioid Macrophages

Tuesday, April 17 | 2:30PM - 4:30PM
Workshop 2: HIV, TB and Other Co-Infections (Joint)
Room: Macdonald Ballroom

Speaker 10 of 10
Fatoumatta Darboe, Medical Research Council, The Gambia Unit, Gambia
A Transcriptomic Risk Signature Predicts Subclinical TB in HIV-Infected Persons on Highly Active Antiretroviral Therapy

Tuesday, April 17 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Tuesday, April 17 | 5:00PM - 7:00PM
Immune-Pathogen Interaction: Containment or Progression?
Room: Macdonald ABC

Speaker 1 of 6
* Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands

Tuesday, April 17 | 5:00PM - 7:00PM
Immune-Pathogen Interaction: Containment or Progression?
Room: Macdonald ABC

Speaker 2 of 6
* Clifton E. Barry III, NIAID, National Institutes of Health, USA

Tuesday, April 17 | 5:00PM - 7:00PM
Immune-Pathogen Interaction: Containment or Progression?
Room: Macdonald ABC

Speaker 3 of 6
Bryan D. Bryson, Massachusetts Institute of Technology, USA
Enhancing Control of Mycobacterium tuberculosis Infection with Single-cell Resolution

Tuesday, April 17 | 5:00PM - 7:00PM
Immune-Pathogen Interaction: Containment or Progression?
Room: Macdonald ABC

Speaker 4 of 6
Christina L. Stallings, Washington University School of Medicine, USA
Innate Immune Determinants of TB Progression

Tuesday, April 17 | 5:00PM - 7:00PM
Immune-Pathogen Interaction: Containment or Progression?
Room: Macdonald ABC

Speaker 5 of 6
David M. Lewinsohn, Oregon Health & Science University, USA
MAIT Cell Responses to the TB Metabolome and Implications for Vaccine Development

Tuesday, April 17 | 5:00PM - 7:00PM
Immune-Pathogen Interaction: Containment or Progression?
Room: Macdonald ABC

Speaker 6 of 6
Daisy Xiaoxi Ji, University of California, Berkeley, USA
Short Talk: A Mechanism for Interferon-Driven Susceptibility to M. tuberculosis

Tuesday, April 17 | 5:00PM - 7:00PM
New Insights in Pathogenesis: Tissue Is the Issue
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 1 of 7
* Marianne E. Jansson, Lund University, Sweden


Tuesday, April 17 | 5:00PM - 7:00PM
New Insights in Pathogenesis: Tissue Is the Issue
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 2 of 7
* Thomas J. Hope, Northwestern University, USA


Tuesday, April 17 | 5:00PM - 7:00PM
New Insights in Pathogenesis: Tissue Is the Issue
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 3 of 7
Michael R. Betts, University of Pennsylvania, USA
Lymphocyte Trafficking in HIV Infection


Tuesday, April 17 | 5:00PM - 7:00PM
New Insights in Pathogenesis: Tissue Is the Issue
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 4 of 7
Eli Andrew Boritz, NIAID, National Institutes of Health, USA
HIV Reservoirs in Lymph Nodes


Tuesday, April 17 | 5:00PM - 7:00PM
New Insights in Pathogenesis: Tissue Is the Issue
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 5 of 7
Shelli Farhadian, Yale School of Medicine, USA
Short Talk: Single-Cell RNA Sequencing to Characterize CSF during Virologically Suppressed HIV


Tuesday, April 17 | 5:00PM - 7:00PM
New Insights in Pathogenesis: Tissue Is the Issue
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 6 of 7
Abigail E. Schiff, Harvard University, USA
Short Talk: Investigation of Alveolar Macrophage Phagocytosis of HIV-Infected T Cells as a Mechanism of HIV-1 Entry into Macrophages


Tuesday, April 17 | 5:00PM - 7:00PM
New Insights in Pathogenesis: Tissue Is the Issue
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 7 of 7
Johanne Hovgaard Egedal, Aarhus University, Denmark
Short Talk: Hyaluronic Acid on Mucosal Fibroblasts Limits their Ability to Enhance HIV Infection of CD4+ T Cells


Tuesday, April 17 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, April 18 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac/Empress


Wednesday, April 18 | 8:00AM - 11:15AM
HIV and TB: Double Trouble (Joint)
Room: Macdonald Ballroom

Speaker 1 of 9
* Michaela Müller-Trutwin, Institut Pasteur, France

Wednesday, April 18 | 8:00AM - 11:15AM
HIV and TB: Double Trouble (Joint)
Room: Macdonald Ballroom

Speaker 2 of 9
* Richard E. Chaisson, Johns Hopkins University, USA

Wednesday, April 18 | 8:00AM - 11:15AM
HIV and TB: Double Trouble (Joint)
Room: Macdonald Ballroom

Speaker 3 of 9
Graeme Meintjes, University of Cape Town, South Africa
High Early Mortality in Patients Diagnosed with HIV-Associated TB in Hospital

Wednesday, April 18 | 8:00AM - 11:15AM
HIV and TB: Double Trouble (Joint)
Room: Macdonald Ballroom

Speaker 4 of 9
Gregory Bisson, University of Pennsylvania, USA
To Have and Have Not: Immune Restoration and Lung Injury in HIV/TB


Wednesday, April 18 | 8:00AM - 11:15AM
HIV and TB: Double Trouble (Joint)
Room: Macdonald Ballroom


Coffee Break

Wednesday, April 18 | 8:00AM - 11:15AM
HIV and TB: Double Trouble (Joint)
Room: Macdonald Ballroom

Speaker 6 of 9
Irini Sereti, NIAID, National Institutes of Health, USA
Role of Co-Infections in HIV Inflammation and Persistence

Wednesday, April 18 | 8:00AM - 11:15AM
HIV and TB: Double Trouble (Joint)
Room: Macdonald Ballroom

Speaker 7 of 9
Henry Charles Mwandumba, Liverpool School of Tropical Medicine, UK
HIV and TB Co-Infection: A View from the Lungs

Wednesday, April 18 | 8:00AM - 11:15AM
HIV and TB: Double Trouble (Joint)
Room: Macdonald Ballroom

Speaker 8 of 9
Daniel Kalman, Emory University, USA
Short Talk: The Imatinib-TB Clinical Trial

Wednesday, April 18 | 8:00AM - 11:15AM
HIV and TB: Double Trouble (Joint)
Room: Macdonald Ballroom

Speaker 9 of 9
Mark Andrew Rodgers, University of Pittsburgh, USA
Short Talk: Pre-Existing SIV Infection Increases Susceptibility of Mauritian Cynomolgus Macaques to M. tuberculosis

Wednesday, April 18 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, April 18 | 11:15AM - 1:00PM
Poster Setup
Room: Frontenac/Empress


Wednesday, April 18 | 11:15AM - 12:15PM
Grantsmanship Workshop presented by NIAID (Joint)
Room: Macdonald Ballroom
NIAID Workshop Objectives:
Come find out what happens to your applications after you submit it to the NIH. NIAID staff will provide attendees with an overview of NIH peer-review, and provide some grantsmanship tips. NIAID Program Officers and Scientific Review Officers will explain their role in shepherding your grants/proposals through the process. Staff will also provide attendees with resources that will alert them to NIAID funding opportunities and discuss specific opportunities targeted to research in mycobacterial diseases. Finally, time permitting staff will discuss various career opportunities within the NIH.
Speaker 1 of 6
* Alison Kraigsley, NIAID, National Institutes of Health, USA

Wednesday, April 18 | 11:15AM - 12:15PM
Grantsmanship Workshop presented by NIAID (Joint)
Room: Macdonald Ballroom
NIAID Workshop Objectives:
Come find out what happens to your applications after you submit it to the NIH. NIAID staff will provide attendees with an overview of NIH peer-review, and provide some grantsmanship tips. NIAID Program Officers and Scientific Review Officers will explain their role in shepherding your grants/proposals through the process. Staff will also provide attendees with resources that will alert them to NIAID funding opportunities and discuss specific opportunities targeted to research in mycobacterial diseases. Finally, time permitting staff will discuss various career opportunities within the NIH.
Speaker 2 of 6
* Karen Lacourciere, NIAID, National Institutes of Health, USA

Wednesday, April 18 | 11:15AM - 12:15PM
Grantsmanship Workshop presented by NIAID (Joint)
Room: Macdonald Ballroom
NIAID Workshop Objectives:
Come find out what happens to your applications after you submit it to the NIH. NIAID staff will provide attendees with an overview of NIH peer-review, and provide some grantsmanship tips. NIAID Program Officers and Scientific Review Officers will explain their role in shepherding your grants/proposals through the process. Staff will also provide attendees with resources that will alert them to NIAID funding opportunities and discuss specific opportunities targeted to research in mycobacterial diseases. Finally, time permitting staff will discuss various career opportunities within the NIH.
Speaker 3 of 6
* Susana Mendez, NIAID, National Institutes of Health, USA

Wednesday, April 18 | 11:15AM - 12:15PM
Grantsmanship Workshop presented by NIAID (Joint)
Room: Macdonald Ballroom
NIAID Workshop Objectives:
Come find out what happens to your applications after you submit it to the NIH. NIAID staff will provide attendees with an overview of NIH peer-review, and provide some grantsmanship tips. NIAID Program Officers and Scientific Review Officers will explain their role in shepherding your grants/proposals through the process. Staff will also provide attendees with resources that will alert them to NIAID funding opportunities and discuss specific opportunities targeted to research in mycobacterial diseases. Finally, time permitting staff will discuss various career opportunities within the NIH.
Speaker 4 of 6
* Vasundhara Varthakavi, NIDA, National Institutes of Health, USA

Wednesday, April 18 | 11:15AM - 12:15PM
Grantsmanship Workshop presented by NIAID (Joint)
Room: Macdonald Ballroom
NIAID Workshop Objectives:
Come find out what happens to your applications after you submit it to the NIH. NIAID staff will provide attendees with an overview of NIH peer-review, and provide some grantsmanship tips. NIAID Program Officers and Scientific Review Officers will explain their role in shepherding your grants/proposals through the process. Staff will also provide attendees with resources that will alert them to NIAID funding opportunities and discuss specific opportunities targeted to research in mycobacterial diseases. Finally, time permitting staff will discuss various career opportunities within the NIH.
Speaker 5 of 6
* Roberta Binder, NIAID, National Institutes of Health, USA

Wednesday, April 18 | 11:15AM - 12:15PM
Grantsmanship Workshop presented by NIAID (Joint)
Room: Macdonald Ballroom
NIAID Workshop Objectives:
Come find out what happens to your applications after you submit it to the NIH. NIAID staff will provide attendees with an overview of NIH peer-review, and provide some grantsmanship tips. NIAID Program Officers and Scientific Review Officers will explain their role in shepherding your grants/proposals through the process. Staff will also provide attendees with resources that will alert them to NIAID funding opportunities and discuss specific opportunities targeted to research in mycobacterial diseases. Finally, time permitting staff will discuss various career opportunities within the NIH.
Speaker 6 of 6
* Chelsea Boyd, NIAID, National Institutes of Health, USA

Wednesday, April 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Frontenac/Empress


Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: MTB Growth and Death
Room: Macdonald ABC

Speaker 1 of 10
* Bavesh Davandra Kana, University of the Witwatersrand, South Africa

Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: MTB Growth and Death
Room: Macdonald ABC

Speaker 2 of 10
* Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA

Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: MTB Growth and Death
Room: Macdonald ABC

Speaker 3 of 10
Piyali S. Basu, University of Surrey, UK
Nitrogen Metabolism in Mycobacterium tuberculosis: A Systems-Based Approach

Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: MTB Growth and Death
Room: Macdonald ABC

Speaker 4 of 10
Viktoria Betin, Harvard University, USA
Determining How Mycobacterium tuberculosis Transcriptional Regulators Influence Intracellular Replication

Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: MTB Growth and Death
Room: Macdonald ABC

Speaker 5 of 10
Allison F. Carey, Harvard School of Public Health, USA
TnSeq of M. tuberculosis Clinical Isolates Reveals Strain-Specific Antibiotic Liabilities

Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: MTB Growth and Death
Room: Macdonald ABC

Speaker 6 of 10
Marcus A. Horwitz, University of California, Los Angeles, USA
Identification by Parabolic Response Surface Methodology of a Universal TB Drug Treatment Regimen that, Compared with the Standard Regimen, Reduces the Time to Achieve Relapse-Free Cure in Mice from 20 Weeks to Only 4 Weeks

Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: MTB Growth and Death
Room: Macdonald ABC

Speaker 7 of 10
Johana Hernandez, University of Surrey, UK
Investigating Candidate Genes Affecting Persistence (drug tolerance) of Mycobacterium tuberculosis Obtained by Tn-Seq Analysis

Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: MTB Growth and Death
Room: Macdonald ABC

Speaker 8 of 10
Christopher R. Covey, University of Colorado, USA
Myocbactin Inhibits Clofazimine Killing of Mycobacteria

Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: MTB Growth and Death
Room: Macdonald ABC

Speaker 9 of 10
John T. Williams, Michigan State University, USA
Novel Inhibitors that Kill Mycobacterium tuberculosis by Targeting MmpL3

Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: MTB Growth and Death
Room: Macdonald ABC

Speaker 10 of 10
Hua Wang, Francis Crick Institute, UK
The Discovery of a Multi-Functional acyl-CoA Lyase Shared by Three Metabolic Pathways in Mycobacterium tuberculosis

Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: Persistence, Latency and Eradication
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 1 of 10
* Remi Fromentin, Le Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Canada


Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: Persistence, Latency and Eradication
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 2 of 10
* Alberto Bosque, George Washington University, USA


Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: Persistence, Latency and Eradication
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 3 of 10
Christina Gavegnano, Emory University, USA
Baricitinib Reverses HIV-Associated Neurocognitive Disorders and Reservoir Seeding in a SCID Mouse Model


Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: Persistence, Latency and Eradication
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 4 of 10
Patrick Budylowski, University or Toronto, Canada
Discovering Novel Surface Biomarkers on Latent HIV-Infected CD4 T Cells using VLR Antibodies


Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: Persistence, Latency and Eradication
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 5 of 10
Namita Satija, Icahn School of Medicine at Mount Sinai, USA
A Genetically Encoded Switch to Monitor HIV Latent Cells in Humanized Mice


Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: Persistence, Latency and Eradication
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 6 of 10
Mykola Pinkevych, University of New South Wales, Australia
Using a Barcoded Virus to Assess Replication Competent SIV Reservoir Size


Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: Persistence, Latency and Eradication
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 7 of 10
Sara Cristinelli, University of Lausanne, Switzerland
Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-Infected Cells


Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: Persistence, Latency and Eradication
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 8 of 10
Gregory Q. Del Prete, Frederick National Laboratory for Cancer Research, USA
CD4 Depletion in SIV-Infected Macaques on Early ART Has No Impact on Viral Rebound


Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: Persistence, Latency and Eradication
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 9 of 10
Maria-Louise Røn Kobberø, Aarhus University Hospital, Denmark
Immunological Effects of Toll-Like Receptor 9 Agonist Treatment in Lymph Nodes of HIV-1+ Adults on ART


Wednesday, April 18 | 2:30PM - 4:30PM
Workshop 3: Persistence, Latency and Eradication
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 10 of 10
Mirko Paiardini, Emory University, YNPRC, USA
IL-10 Signaling Contributes to Viral Persistence in ART-Treated, SIV-Infected Rhesus Macaques


Wednesday, April 18 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Wednesday, April 18 | 5:00PM - 7:00PM
The Cellular, Anatomical and Pathological Niches of TB Infec
tion and Disease

Room: Macdonald ABC

Speaker 1 of 6
* David M. Lewinsohn, Oregon Health & Science University, USA

Wednesday, April 18 | 5:00PM - 7:00PM
The Cellular, Anatomical and Pathological Niches of TB Infec
tion and Disease

Room: Macdonald ABC

Speaker 2 of 6
* Graeme Meintjes, University of Cape Town, South Africa

Wednesday, April 18 | 5:00PM - 7:00PM
The Cellular, Anatomical and Pathological Niches of TB Infec
tion and Disease

Room: Macdonald ABC

Speaker 3 of 6
Clifton E. Barry III, NIAID, National Institutes of Health, USA
Imaging TB

Wednesday, April 18 | 5:00PM - 7:00PM
The Cellular, Anatomical and Pathological Niches of TB Infec
tion and Disease

Room: Macdonald ABC

Speaker 4 of 6
Sabine Ehrt, Weill Cornell Medical College, USA
Resist, Persist and Divide

Wednesday, April 18 | 5:00PM - 7:00PM
The Cellular, Anatomical and Pathological Niches of TB Infec
tion and Disease

Room: Macdonald ABC

Speaker 5 of 6
Veronique Anne Dartois, Hackensack Meridian Health, USA
Lesion-Centric Pharmacology to Design New Drug Regimens for Tuberculosis

Wednesday, April 18 | 5:00PM - 7:00PM
The Cellular, Anatomical and Pathological Niches of TB Infec
tion and Disease

Room: Macdonald ABC

Speaker 6 of 6
Valerie A.C.M. Koeken, Radboud University Medical Center, Netherlands
Short Talk: Survival of Tuberculous Meningitis Is Linked to Cerebrospinal Fluid Vascular Endothelial Growth Factor (VEGF); a Systems Approach

Wednesday, April 18 | 5:00PM - 7:00PM
HIV and Co-infections: Dangerous Liaison
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 1 of 6
* Neeltje A. Kootstra, Amsterdam UMC, Netherlands


Wednesday, April 18 | 5:00PM - 7:00PM
HIV and Co-infections: Dangerous Liaison
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 2 of 6
* Peter W. Hunt, University of California, San Francisco, USA


Wednesday, April 18 | 5:00PM - 7:00PM
HIV and Co-infections: Dangerous Liaison
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 3 of 6
Andrea Lynn Cox, Johns Hopkins University, USA
HIV- and HCV-Induced Inflammation


Wednesday, April 18 | 5:00PM - 7:00PM
HIV and Co-infections: Dangerous Liaison
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 4 of 6
Victor Appay, INSERM U1135 - CIMI, France
Immune Aging and Co-Infections in HIV


Wednesday, April 18 | 5:00PM - 7:00PM
HIV and Co-infections: Dangerous Liaison
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 5 of 6
Elena Martinelli, Population Council, USA
Role of Herpes Simplex in HIV/SIV Infection


Wednesday, April 18 | 5:00PM - 7:00PM
HIV and Co-infections: Dangerous Liaison
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 6 of 6
Stephen R. Morris, Louis Stokes Cleveland VA Medical Center, USA
Short Talk: IL-15 Drives the Generation and Survival of Senescent CD8 T Cells in HIV/CMV Co-Infection


Wednesday, April 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Frontenac/Empress
No registration fees are used to fund alcohol served at this function.

Wednesday, April 18 | 7:30PM - 10:00PM
Poster Session 3
Room: Frontenac/Empress


Thursday, April 19 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac/Empress


Thursday, April 19 | 8:00AM - 11:15AM
Bacterial Adaptation
Room: Macdonald ABC

Speaker 1 of 9
* Luiz Pedro Carvalho, Francis Crick Institute, UK

Thursday, April 19 | 8:00AM - 11:15AM
Bacterial Adaptation
Room: Macdonald ABC

Speaker 2 of 9
* Sabine Ehrt, Weill Cornell Medical College, USA

Thursday, April 19 | 8:00AM - 11:15AM
Bacterial Adaptation
Room: Macdonald ABC

Speaker 3 of 9
David Alland, Rutgers University, New Jersey Medical School, USA
Genetic Diversity of Mycobacterium tuberculosis as a Driver of Drug Resistance and Relapse in Human TB

Thursday, April 19 | 8:00AM - 11:15AM
Bacterial Adaptation
Room: Macdonald ABC

Speaker 4 of 9
Stefan Niemann, Research Center Borstel, Germany
Recent Evolution and Transmission of MDR M. tuberculosis Strains

Thursday, April 19 | 8:00AM - 11:15AM
Bacterial Adaptation
Room: Macdonald ABC


Coffee Break

Thursday, April 19 | 8:00AM - 11:15AM
Bacterial Adaptation
Room: Macdonald ABC

Speaker 6 of 9
Hesper Rego, Yale Medical School, USA
Exploring the Molecular Basis of Pathogen Heterogeneity

Thursday, April 19 | 8:00AM - 11:15AM
Bacterial Adaptation
Room: Macdonald ABC

Speaker 7 of 9
Sarah Bwabye Namugenyi, University of Minnesota, USA
Short Talk: Identification of Mycobacterium tuberculosis Immune Evasion Mechanisms using Tn-seq

Thursday, April 19 | 8:00AM - 11:15AM
Bacterial Adaptation
Room: Macdonald ABC

Speaker 8 of 9
Babak Javid, University of California San Francisco, USA
Targeting Mycobacterial Adaptive Mistranslation in Vitro and in Vivo

Thursday, April 19 | 8:00AM - 11:15AM
Bacterial Adaptation
Room: Macdonald ABC

Speaker 9 of 9
Eduardo Pinheiro Amaral, NIAID, National Institutes of Health, USA
Short Talk: Ferroptosis, an Iron-Dependent Cell Death Modality, Is a Major Mechanism of Regulated Necrosis in Mycobacterium tuberculosis Infection

Thursday, April 19 | 8:00AM - 11:15AM
HIV Persistence and Latency: The Enemy Within
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 1 of 9
* Camille M. Lange, National Cancer Institute, USA


Thursday, April 19 | 8:00AM - 11:15AM
HIV Persistence and Latency: The Enemy Within
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 2 of 9
* Mark Brockman, Simon Fraser University, Canada


Thursday, April 19 | 8:00AM - 11:15AM
HIV Persistence and Latency: The Enemy Within
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 3 of 9
B. Matija Peterlin, University of California, San Francisco, USA
HIV Latency and Reactivation


Thursday, April 19 | 8:00AM - 11:15AM
HIV Persistence and Latency: The Enemy Within
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 4 of 9
Nicolas Chomont, Université de Montréal, Canada
HIV Persistence and Aging


Thursday, April 19 | 8:00AM - 11:15AM
HIV Persistence and Latency: The Enemy Within
This session is from HIV Pathogenesis
Room: Macdonald DEF


Coffee Break


Thursday, April 19 | 8:00AM - 11:15AM
HIV Persistence and Latency: The Enemy Within
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 6 of 9
Ya-Chi Ho, Yale School of Medicine, USA
HIV-1 Viral and Proviral Landscape


Thursday, April 19 | 8:00AM - 11:15AM
HIV Persistence and Latency: The Enemy Within
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 7 of 9
James I. Mullins, University of Washington, USA
HIV Integration Sites and Selection for Infected Cell Survival in Persisting Reservoirs


Thursday, April 19 | 8:00AM - 11:15AM
HIV Persistence and Latency: The Enemy Within
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 8 of 9
Kelsie Brooks, Emory University, USA
Short Talk: Proviral Sequences of the Reservoir Demonstrate Archiving of Transmitted/Founder Virus-Like Variants


Thursday, April 19 | 8:00AM - 11:15AM
HIV Persistence and Latency: The Enemy Within
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 9 of 9
Timothée Bruel, Institut Pasteur, France
Short Talk: Characterization of Circulating CD32a+ CD4 T Cells and Identification of Potent ADCC-Mediating CD32 Antibodies


Thursday, April 19 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, April 19 | 2:30PM - 4:30PM
Workshop 4: The Immune Response to TB
Room: Macdonald ABC

Speaker 1 of 10
* Bryan D. Bryson, Massachusetts Institute of Technology, USA

Thursday, April 19 | 2:30PM - 4:30PM
Workshop 4: The Immune Response to TB
Room: Macdonald ABC

Speaker 2 of 10
* Thomas J. Scriba, University of Cape Town, South Africa

Thursday, April 19 | 2:30PM - 4:30PM
Workshop 4: The Immune Response to TB
Room: Macdonald ABC

Speaker 3 of 10
Jayne S. Sutherland, Medical Research Council, Gambia
Analysis of Early Protective Immunity to Mycobacterium tuberculosis Infection

Thursday, April 19 | 2:30PM - 4:30PM
Workshop 4: The Immune Response to TB
Room: Macdonald ABC

Speaker 4 of 10
Amanda Lee Ardain, Africa Health Research Institute, South Africa
Innate Lymphoid Cells Mediate Early Protective Immunity against Mycobacterium tuberculosis

Thursday, April 19 | 2:30PM - 4:30PM
Workshop 4: The Immune Response to TB
Room: Macdonald ABC

Speaker 5 of 10
Eusondia Arnett, Texas Biomedical Research Institute, USA
Use of a Tissue Culture Model to Characterize M. tuberculosis HIV Co-Infected Human Granuloma Development

Thursday, April 19 | 2:30PM - 4:30PM
Workshop 4: The Immune Response to TB
Room: Macdonald ABC

Speaker 6 of 10
Julie Boucau, Ragon Institute of MGH, MIT and Harvard, USA
Mycobacterium tuberculosis Antigens Are Differentially Degraded into Epitopes by Human Monocyte-Derived Dendritic Cells and Macrophages

Thursday, April 19 | 2:30PM - 4:30PM
Workshop 4: The Immune Response to TB
Room: Macdonald ABC

Speaker 7 of 10
Natasha M. Bourgeois, University of Washington School of Medicine, USA
Host-Directed Macrophage Therapy with Kinase Inhibitors Limit Mycobacterium tuberculosis Replication and Modulate Cytokine Signaling

Thursday, April 19 | 2:30PM - 4:30PM
Workshop 4: The Immune Response to TB
Room: Macdonald ABC

Speaker 8 of 10
Alissa C. Rothchild, University of Massachusetts Amherst, USA
In vivo Response of Alveolar Macrophages to Mycobacterium tuberculosis

Thursday, April 19 | 2:30PM - 4:30PM
Workshop 4: The Immune Response to TB
Room: Macdonald ABC

Speaker 9 of 10
Munyaradzi Nyasha Musvosvi, University of Cape Town, South Africa
T Cell Biomarkers for Diagnosis of Tuberculosis: Candidate Evaluation by a Simple Whole Blood Assay for Clinical Translation

Thursday, April 19 | 2:30PM - 4:30PM
Workshop 4: The Immune Response to TB
Room: Macdonald ABC

Speaker 10 of 10
Michael D. Stutz, Australia
Harnessing the Therapeutic Potential of Endogenous TNF for the Treatment of Tuberculosis

Thursday, April 19 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Thursday, April 19 | 5:00PM - 6:45PM
New Frontiers in TB Diagnostics and Treatment
Room: Macdonald ABC

Speaker 1 of 4
* David Alland, Rutgers University, New Jersey Medical School, USA

Thursday, April 19 | 5:00PM - 6:45PM
New Frontiers in TB Diagnostics and Treatment
Room: Macdonald ABC

Speaker 2 of 4
Bavesh Davandra Kana, University of the Witwatersrand, South Africa
Differentially Culturable Tubercle Bacteria: Implications for Diagnosis and Measuring Treatment Efficacy


Thursday, April 19 | 5:00PM - 6:45PM
New Frontiers in TB Diagnostics and Treatment
Room: Macdonald ABC

Speaker 3 of 4
Nader Fotouhi, TB Alliance, USA
TB Alliance Drugs in Development

Thursday, April 19 | 5:00PM - 6:45PM
New Frontiers in TB Diagnostics and Treatment
Room: Macdonald ABC

Speaker 4 of 4
Jane Hill, Dartmouth College, USA
Exhaled Breath: A Diagnostic Fluid that also Generates Insight into Pathogenesis

Thursday, April 19 | 5:00PM - 6:45PM
Strategies for HIV Remission and Cure
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 1 of 5
* Jana Blazkova, NIAID, National Institutes of Health, USA


Thursday, April 19 | 5:00PM - 6:45PM
Strategies for HIV Remission and Cure
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 2 of 5
* Michael M. Lederman, Case Western Reserve University, USA


Thursday, April 19 | 5:00PM - 6:45PM
Strategies for HIV Remission and Cure
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 3 of 5
Asier Sáez-Cirión, Institut Pasteur, France
Cell Metabolism and HIV Control


Thursday, April 19 | 5:00PM - 6:45PM
Strategies for HIV Remission and Cure
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 4 of 5
Romas Geleziunas, Gilead Sciences, Inc., USA
TLR7 Agonists for HIV


Thursday, April 19 | 5:00PM - 6:45PM
Strategies for HIV Remission and Cure
This session is from HIV Pathogenesis
Room: Macdonald DEF

Speaker 5 of 5
Paula M. Cannon, University of Southern California, Keck School of Medicine, USA
Genetic Strategies for HIV Cure


Thursday, April 19 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Macdonald ABC


Thursday, April 19 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from HIV Pathogenesis
Room: Macdonald DEF


Thursday, April 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Frontenac/Empress
No registration fees are used to fund alcohol served at this function.

Thursday, April 19 | 8:00PM - 11:00PM
Entertainment
Room: Frontenac
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, April 19 | 8:00PM - 11:00PM
Cash Bar
Room: Frontenac


Friday, April 20 | 10:24AM - 10:24AM
Departure


*Session Chair.