Web Desc
Mitochondrial Biology
joint with Selective Autophagy
Organizer(s): Jodi Nunnari, Anu Suomalainen-Wartiovaara and Koji Okamoto
Date: April 22 - 26, 2018
Location: Westin Miyako Kyoto, Kyoto, Japan
Sponsored by Astellas Pharma Inc. and Nestlé Institute of Health Sciences
Summary of Meeting:
Mitochondria perform fundamental diverse functions in eukaryotic cells, including ATP production and ion and phospholipid homeostasis. They also serve as platforms to integrate signaling pathways and cellular processes, such as innate immunity and autophagy. Mitochondrial functions are tightly linked to mitochondrial form, which is established through coordinated machines that control dynamics, positioning, motility and mitochondrial DNA transmission. Contact sites between mitochondrial with diverse organelles have emerged as key and pervasive regulators of mitochondrial form and function. These contact sites, as well as metabolites, fully integrate mitochondria into the cell and organism. It is therefore not surprising that mitochondrial dysfunction has emerged as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders. This conference will provide a cutting-edge view of how mitochondrial form and function is controlled and how its myriad of functions impinge on health and disease.
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Astellas Pharma Inc.Nestlé Institute of Health Sciences
We gratefully acknowledge additional support for this conference from:
BioElectron Technology Corporation
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA228548-01
Funding for this conference was made possible (in part) by 1R13CA228548-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 22 | 4:00PM - 8:00PM
Arrival and Registration
Room: Mizuho Foyer


Sunday, April 22 | 6:00PM - 8:00PM
Welcome Mixer
Room: Mizuho Foyer
No registration fees are used to fund alcohol served at this function.

Monday, April 23 | 7:30AM - 8:00AM
Poster Setup
Room: Mizuho


Monday, April 23 | 8:00AM - 5:00PM
Poster Viewing
Room: Mizuho


Monday, April 23 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Mizuho

Speaker 1 of 5
* Ivan Dikic, Goethe University Medical School, Germany

Monday, April 23 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Mizuho

Speaker 2 of 5
* Jodi Nunnari, University of California, Davis, USA

Monday, April 23 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Mizuho

Speaker 3 of 5
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
mTOR and Lysosomes in Growth Control

Monday, April 23 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Mizuho

Speaker 4 of 5
Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA
Autophagy's Role in Mitochondrial Function and Dysfunction

Monday, April 23 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Mizuho


Coffee Break

Monday, April 23 | 10:00AM - 12:15PM
Mitochondrial Dynamics
Room: Mizuho

Speaker 1 of 6
* Aleksandra Trifunovic, University of Cologne, Germany

Monday, April 23 | 10:00AM - 12:15PM
Mitochondrial Dynamics
Room: Mizuho

Speaker 2 of 6
Orian S. Shirihai, University of California, Los Angeles, USA
Lipid Droplet Mitochondria: Mitochondria With Agenda

Monday, April 23 | 10:00AM - 12:15PM
Mitochondrial Dynamics
Room: Mizuho

Speaker 3 of 6
David C. Chan, California Institute of Technology, USA
Mitochondrial Fusion and Fission in Health and Disease


Monday, April 23 | 10:00AM - 12:15PM
Mitochondrial Dynamics
Room: Mizuho

Speaker 4 of 6
Thomas Langer, CECAD Research Center, Germany
Proteolytic Control of Mitochondrial Membrane Homeostasis

Monday, April 23 | 10:00AM - 12:15PM
Mitochondrial Dynamics
Room: Mizuho

Speaker 5 of 6
Hiromi Sesaki, Johns Hopkins University School of Medicine, USA
Short Talk: Human Brain Evolution Driven by Drp1

Monday, April 23 | 10:00AM - 12:15PM
Mitochondrial Dynamics
Room: Mizuho

Speaker 6 of 6
Naotada Ishihara, Kurume University, Japan
Short Talk: Selective Mitochondrial Fusion by Heterotypic Action between OPA1 and Cardiolipin

Monday, April 23 | 10:00AM - 12:15PM
Aggrephagy and Neurodegenerative Disease
This session is from Autophagy
Room: Yamashiro

Speaker 1 of 6
* Masaaki Komatsu, Juntendo University School of Medicine, Japan


Monday, April 23 | 10:00AM - 12:15PM
Aggrephagy and Neurodegenerative Disease
This session is from Autophagy
Room: Yamashiro

Speaker 2 of 6
Ai Yamamoto, Columbia University, USA
Selective Autophagy in the CNS


Monday, April 23 | 10:00AM - 12:15PM
Aggrephagy and Neurodegenerative Disease
This session is from Autophagy
Room: Yamashiro

Speaker 3 of 6
Hong Zhang, Chinese Academy of Sciences, China
Loss of Collagen Related to the Cuticle Annular Furrow Activates Systemic Autophagy


Monday, April 23 | 10:00AM - 12:15PM
Aggrephagy and Neurodegenerative Disease
This session is from Autophagy
Room: Yamashiro

Speaker 4 of 6
Anne Simonsen, University of Oslo, Norway
Regulation of Selective Autophagy


Monday, April 23 | 10:00AM - 12:15PM
Aggrephagy and Neurodegenerative Disease
This session is from Autophagy
Room: Yamashiro

Speaker 5 of 6
Maneka Chitiprolu, University of Ottawa, Canada
Short Talk: A Complex of C9ORF72 and p62 Uses Arginine Methylation to Eliminate FUS and Stress Granules by Autophagy


Monday, April 23 | 10:00AM - 12:15PM
Aggrephagy and Neurodegenerative Disease
This session is from Autophagy
Room: Yamashiro

Speaker 6 of 6
Santosh Chauhan, Institute of Life Sciences, India
Short Talk: TRIM16 Control Protein Aggregates Turnover by Regulating NRF2-p62 Axis and Autophagy Process


Monday, April 23 | 12:15PM - 1:45PM
Lunch
Room: Mizuho


Monday, April 23 | 12:45PM - 2:45PM
Poster Session 1
Room: Mizuho


Monday, April 23 | 2:45PM - 4:45PM
Workshop 1: Dynamics
Room: Mizuho

Speaker 1 of 9
* Laura L. Lackner, Northwestern University, USA

Monday, April 23 | 2:45PM - 4:45PM
Workshop 1: Dynamics
Room: Mizuho

Speaker 2 of 9
Suzanne Hoppins, University of Washington, USA
Identification of a New Functional Domain in the Mitofusin Proteins

Monday, April 23 | 2:45PM - 4:45PM
Workshop 1: Dynamics
Room: Mizuho

Speaker 3 of 9
Mickael Cohen, CNRS-UPMC, France
Mechanism and Regulation of Homotypic Fusion between Outer Membranes

Monday, April 23 | 2:45PM - 4:45PM
Workshop 1: Dynamics
Room: Mizuho

Speaker 4 of 9
Alessandra Maresca, IRCCS Istituto Scienze Neurologiche, Italy
OPA3 Mutations Highlight a Patho-Mechanism Involving Fission and Autophagy

Monday, April 23 | 2:45PM - 4:45PM
Workshop 1: Dynamics
Room: Mizuho

Speaker 5 of 9
Cecilia Patitucci, Université de Paris Descartes, France
The Role of MTP18 in Mitochondrial Dynamics and Metabolism

Monday, April 23 | 2:45PM - 4:45PM
Workshop 1: Dynamics
Room: Mizuho

Speaker 6 of 9
Ken Nakamura, University of California, San Francisco, USA
A High-Throughput Screen of Real-Time ATP Levels in Individual Cells Reveals Mechanisms of Energy Failure

Monday, April 23 | 2:45PM - 4:45PM
Workshop 1: Dynamics
Room: Mizuho

Speaker 7 of 9
Juliette Lee, University of Cambridge, UK
Basal Mitophagy Is Widespread in Drosophila but Minimally Affected by Loss of Pink1 or Parkin

Monday, April 23 | 2:45PM - 4:45PM
Workshop 1: Dynamics
Room: Mizuho

Speaker 8 of 9
Thomas Rival, Aix-Marseille Université, France
Mitofusin Mutations Commonly Associated with Charcot-Marie-Tooth Neuropathy Have Opposite Effects on Mitochondrial Fusion

Monday, April 23 | 2:45PM - 4:45PM
Workshop 1: Dynamics
Room: Mizuho

Speaker 9 of 9
Ramona Schuster, Institute for Genetics, University of Cologne, Germany
Cdc48 Regulates a Deubiquitylase Cascade Critical for Mitochondrial Fusion

Monday, April 23 | 3:00PM - 4:30PM
Workshop 1
This session is from Autophagy
Room: Yamashiro

Speaker 1 of 6
* Hong Zhang, Chinese Academy of Sciences, China


Monday, April 23 | 3:00PM - 4:30PM
Workshop 1
This session is from Autophagy
Room: Yamashiro

Speaker 2 of 6
Christian Behl, University Medical Center of the Johannes Gutenberg University, Germany
RAB18 Modulates Autophagosome Formation and is Functionally Compensated by ATG9A


Monday, April 23 | 3:00PM - 4:30PM
Workshop 1
This session is from Autophagy
Room: Yamashiro

Speaker 3 of 6
Yasin Dagdas, Gregor Mendel Institute, Austria
Role of Autophagy in Phenotypic Plasticity Responses in Plants


Monday, April 23 | 3:00PM - 4:30PM
Workshop 1
This session is from Autophagy
Room: Yamashiro

Speaker 4 of 6
Marie Witt, Max-Delbrück-Center for Molecular Medicine, Germany
Structure-Function Studies on FIP200 Reveal Mechanistic Insights into Selective Autophagy


Monday, April 23 | 3:00PM - 4:30PM
Workshop 1
This session is from Autophagy
Room: Yamashiro

Speaker 5 of 6
Liang Ge, Tsinghua University, China
Endomembrane Remodeling in Autophagic Membrane Formation


Monday, April 23 | 3:00PM - 4:30PM
Workshop 1
This session is from Autophagy
Room: Yamashiro

Speaker 6 of 6
Maho Hamasaki, Osaka University, Japan
Chemical Activation of LC3 Conjugation System Uncover the New Insight of LC3 Lipidation Site


Monday, April 23 | 4:30PM - 5:00PM
Coffee Available
Room: Mizuho Foyer


Monday, April 23 | 5:00PM - 7:15PM
Mitochondrial Quality Control
Room: Mizuho

Speaker 1 of 6
* Richard J. Youle, NINDS, National Institutes of Health, USA

Monday, April 23 | 5:00PM - 7:15PM
Mitochondrial Quality Control
Room: Mizuho

Speaker 2 of 6
Luca Scorrano, University of Padova, Italy
Localized Accumulation of Autophagosomes at Axonal Hillocks Depletes Axons from Damaged Mitochondria

Monday, April 23 | 5:00PM - 7:15PM
Mitochondrial Quality Control
Room: Mizuho

Speaker 3 of 6
Andrew G. Dillin, University of California, Berkeley, USA
Mitochondrial Unfolded Protein Responses

Monday, April 23 | 5:00PM - 7:15PM
Mitochondrial Quality Control
Room: Mizuho

Speaker 4 of 6
Aleksandra Trifunovic, University of Cologne, Germany
Quality Control of Mitochondrial Complex I

Monday, April 23 | 5:00PM - 7:15PM
Mitochondrial Quality Control
Room: Mizuho

Speaker 5 of 6
Adam L. Hughes, University of Utah, USA
Short Talk: The Nucleus Is a Common Quality Control Destination for Failed Mitochondrial Import Substrates

Monday, April 23 | 5:00PM - 7:15PM
Mitochondrial Quality Control
Room: Mizuho

Speaker 6 of 6
Felix Boos, University of Kaiserslautern, Germany
Short Talk: Dissolving the Traffic Jam – How Cells Counteract the Blockage of Mitochondrial Protein Entry Gates

Monday, April 23 | 5:00PM - 7:00PM
Autophagy Receptors and Other Machinery in Selective Autopha
gy
This session is from Autophagy

Room: Yamashiro

Speaker 1 of 5
* Noboru Mizushima, University of Tokyo, Japan


Monday, April 23 | 5:00PM - 7:00PM
Autophagy Receptors and Other Machinery in Selective Autopha
gy
This session is from Autophagy

Room: Yamashiro

Speaker 2 of 5
Sascha Martens, University of Vienna, Austria
Templating Autophagosomal Membrane Growth during Selective Autophagy


Monday, April 23 | 5:00PM - 7:00PM
Autophagy Receptors and Other Machinery in Selective Autopha
gy
This session is from Autophagy

Room: Yamashiro

Speaker 3 of 5
Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain
Mitophagy as a Regulator of Metabolism and Cell Differentiation


Monday, April 23 | 5:00PM - 7:00PM
Autophagy Receptors and Other Machinery in Selective Autopha
gy
This session is from Autophagy

Room: Yamashiro

Speaker 4 of 5
Christian Behrends, Ludwig Maximilians University München, Germany
Autophagosomal Content Profiling as a Tool to Dissect the Contribution of Autophagy to Proteostasis


Monday, April 23 | 5:00PM - 7:00PM
Autophagy Receptors and Other Machinery in Selective Autopha
gy
This session is from Autophagy

Room: Yamashiro

Speaker 5 of 5
Michael Lazarou, Monash University, Australia
Short Talk: LC3/GABARAPs Drive Ubiquitin-Independent Recruitment of Optineurin and NDP52 to Amplify Mitophagy


Monday, April 23 | 7:15PM - 7:15PM
On Own for Dinner


Tuesday, April 24 | 8:00AM - 11:15AM
Mitophagy (Joint)
Room: Mizuho

Speaker 1 of 9
* Nikolaus Pfanner, University of Freiburg, Germany

Tuesday, April 24 | 8:00AM - 11:15AM
Mitophagy (Joint)
Room: Mizuho

Speaker 2 of 9
* Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain

Tuesday, April 24 | 8:00AM - 11:15AM
Mitophagy (Joint)
Room: Mizuho

Speaker 3 of 9
Richard J. Youle, NINDS, National Institutes of Health, USA
Pink1-Parkin Pathway

Tuesday, April 24 | 8:00AM - 11:15AM
Mitophagy (Joint)
Room: Mizuho

Speaker 4 of 9
Ivan Dikic, Goethe University Medical School, Germany
Ubiquitin and TBK1 interplay in Selective Autophagy

Tuesday, April 24 | 8:00AM - 11:15AM
Mitophagy (Joint)
Room: Mizuho


Coffee Break

Tuesday, April 24 | 8:00AM - 11:15AM
Mitophagy (Joint)
Room: Mizuho

Speaker 6 of 9
Erika L. F. Holzbaur, University of Pennsylvania, USA
Dynamics of Autophagy and Mitophagy in Neurons

Tuesday, April 24 | 8:00AM - 11:15AM
Mitophagy (Joint)
Room: Mizuho

Speaker 7 of 9
Koji Okamoto, Osaka University, Japan
Regulation of Mitochondrial Clearance via ER Factors

Tuesday, April 24 | 8:00AM - 11:15AM
Mitophagy (Joint)
Room: Mizuho

Speaker 8 of 9
Jane E. Craig, St. Jude Children's Research Hospital, USA
Short Talk: MEK5/ERK5-Mediated Regulation of Mitophagy

Tuesday, April 24 | 8:00AM - 11:15AM
Mitophagy (Joint)
Room: Mizuho

Speaker 9 of 9
Thomas McWilliams, University of Helsinki, Finland
Short Talk: Resolving Endogenous PINK1-Parkin Activation to in vivo Mitophagy

Tuesday, April 24 | 11:15AM - 12:15PM
Meet the Editors (Joint)

Speaker 1 of 13
* Jodi Nunnari, University of California, Davis, USA

Tuesday, April 24 | 11:15AM - 12:15PM
Meet the Editors (Joint)

Speaker 2 of 13
* Anne Simonsen, University of Oslo, Norway

Tuesday, April 24 | 11:15AM - 12:15PM
Meet the Editors (Joint)

Speaker 3 of 13
Stella M. Hurtley, Science, UK

Tuesday, April 24 | 11:15AM - 12:15PM
Meet the Editors (Joint)

Speaker 4 of 13
Tim Spencer, Journal of Cell Biology, USA

Tuesday, April 24 | 11:15AM - 12:15PM
Meet the Editors (Joint)

Speaker 5 of 13
Sharon Ahmad, Journal of Cell Science, UK

Tuesday, April 24 | 11:15AM - 12:15PM
Meet the Editors (Joint)

Speaker 6 of 13
Robert Kruger, Cell, USA

Tuesday, April 24 | 11:15AM - 12:15PM
Meet the Editors (Joint)

Speaker 7 of 13
Christina Kary, Nature Cell Biology, USA

Tuesday, April 24 | 11:15AM - 12:15PM
Meet the Editors (Joint)

Speaker 8 of 13
Petra Gross, Journal of Cell Science, UK

Tuesday, April 24 | 11:15AM - 12:15PM
Meet the Editors (Joint)

Speaker 9 of 13
Niki Scaplehorn, Nature Communications, UK

Tuesday, April 24 | 11:15AM - 12:15PM
Meet the Editors (Joint)

Speaker 10 of 13
Sadaf Shadan, Nature, UK

Tuesday, April 24 | 11:15AM - 12:15PM
Meet the Editors (Joint)

Speaker 11 of 13
Srividya Chandramouli, Cell Press, USA

Tuesday, April 24 | 11:15AM - 12:15PM
Meet the Editors (Joint)

Speaker 12 of 13
Paulina Jadwiga Strzyz, Nature Reviews Molecular Cell Biology, UK

Tuesday, April 24 | 11:15AM - 12:15PM
Meet the Editors (Joint)

Speaker 13 of 13
Elisabetta Argenzio, EMBO Journal, Germany

Tuesday, April 24 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, April 24 | 11:15AM - 1:00PM
Poster Setup
Room: Mizuho


Tuesday, April 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Mizuho


Tuesday, April 24 | 4:30PM - 5:00PM
Coffee Available
Room: Mizuho Foyer


Tuesday, April 24 | 5:00PM - 7:15PM
Mitochondrial Motility and Distribution
Room: Mizuho

Speaker 1 of 6
* Luca Scorrano, University of Padova, Italy

Tuesday, April 24 | 5:00PM - 7:15PM
Mitochondrial Motility and Distribution
Room: Mizuho

Speaker 2 of 6
Thomas L. Schwarz, Children's Hospital Boston and Harvard Medical School, USA
Mitochondrial Motility

Tuesday, April 24 | 5:00PM - 7:15PM
Mitochondrial Motility and Distribution
Room: Mizuho

Speaker 3 of 6
Benoit Kornmann, ETH Zurich, Switzerland
Mechanical Force Induces Mitochondrial Fission via the Canonical Fission Machinery

Tuesday, April 24 | 5:00PM - 7:15PM
Mitochondrial Motility and Distribution
Room: Mizuho

Speaker 4 of 6
Laura L. Lackner, Northwestern University, USA
Mitochondrial Anchors: Positioning Mitochondria and More

Tuesday, April 24 | 5:00PM - 7:15PM
Mitochondrial Motility and Distribution
Room: Mizuho

Speaker 5 of 6
Guillermo López-Doménech, University College London, UK
Short Talk: Miro Proteins Coordinate Microtubule and Actin-Dependent Mitochondrial Transport and Distribution

Tuesday, April 24 | 5:00PM - 7:15PM
Mitochondrial Motility and Distribution
Room: Mizuho

Speaker 6 of 6
Dane M. Wolf, University of California, Los Angeles, USA
Short Talk: Milton1 Coordinates Mitochondrial Motility, Form, and Function with Nutrient Status in ß Cells

Tuesday, April 24 | 5:00PM - 7:00PM
Xenophagy and Autophagy in Immunity
This session is from Autophagy
Room: Yamashiro

Speaker 1 of 5
* Eric H. Baehrecke, University of Massachusetts Medical School, USA


Tuesday, April 24 | 5:00PM - 7:00PM
Xenophagy and Autophagy in Immunity
This session is from Autophagy
Room: Yamashiro

Speaker 2 of 5
Vojo Deretic, University of New Mexico Health Sciences Center, USA
GALTOR Regulates mTOR and AMPK and Links Metabolic and Quality Control Functions of Autophagy in Endomembrane Damage


Tuesday, April 24 | 5:00PM - 7:00PM
Xenophagy and Autophagy in Immunity
This session is from Autophagy
Room: Yamashiro

Speaker 3 of 5
John Hunter Brumell, Hospital for Sick Children, Canada
How ATG Proteins Limit Listeria Spread


Tuesday, April 24 | 5:00PM - 7:00PM
Xenophagy and Autophagy in Immunity
This session is from Autophagy
Room: Yamashiro

Speaker 4 of 5
Laure-Anne Ligeon, University of Zürich – Institute of Experimental Immunology, Switzerland
Short Talk: Mechanisms of LC3-Associated Phagocytosis for MHC Class II Presentation


Tuesday, April 24 | 5:00PM - 7:00PM
Xenophagy and Autophagy in Immunity
This session is from Autophagy
Room: Yamashiro

Speaker 5 of 5
Rachel Ulferts, University of Cambridge, UK
Short Talk: Influenza A Infection Triggers a Cellular Response that Resembles Autophagy but has a Distinct Molecular Basis


Tuesday, April 24 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Mizuho
No registration fees are used to fund alcohol served at this function.

Tuesday, April 24 | 7:30PM - 10:00PM
Poster Session 2
Room: Mizuho


Wednesday, April 25 | 8:00AM - 11:15AM
Metabolism (Joint)
Room: Mizuho

Speaker 1 of 9
* Jared Rutter, University of Utah, USA

Wednesday, April 25 | 8:00AM - 11:15AM
Metabolism (Joint)
Room: Mizuho

Speaker 2 of 9
* Marja Jäättelä, Danish Cancer Society Research Center, Denmark

Wednesday, April 25 | 8:00AM - 11:15AM
Metabolism (Joint)
Room: Mizuho

Speaker 3 of 9
Andrea Ballabio, Telethon Institute of Genetics and Medicine, Italy
An mTOR-TFEB Feedback Loop Controls the Response to Starvation and Physical Exercise and Is Deregulated in Cancer

Wednesday, April 25 | 8:00AM - 11:15AM
Metabolism (Joint)
Room: Mizuho

Speaker 4 of 9
Masaaki Komatsu, Juntendo University School of Medicine, Japan
Selective Autophagy Regulates Lipid Metabolism

Wednesday, April 25 | 8:00AM - 11:15AM
Metabolism (Joint)
Room: Mizuho


Coffee Break

Wednesday, April 25 | 8:00AM - 11:15AM
Metabolism (Joint)
Room: Mizuho

Speaker 6 of 9
Anu Suomalainen Wartiovaara, University of Helsinki, Finland
Metabolic Basis of Mitochondrial Disease

Wednesday, April 25 | 8:00AM - 11:15AM
Metabolism (Joint)
Room: Mizuho

Speaker 7 of 9
Norbert Perrimon, Harvard Medical School, USA
Physiological Regulation of Organismal Homeostasis

Wednesday, April 25 | 8:00AM - 11:15AM
Metabolism (Joint)
Room: Mizuho

Speaker 8 of 9
Myung-Shik Lee, Yonsei University College of Medicine, South Korea
Short Talk: Role of Mitophagy in Pancreatic Beta Cell Function

Wednesday, April 25 | 8:00AM - 11:15AM
Metabolism (Joint)
Room: Mizuho

Speaker 9 of 9
Martin Graef, Max Planck Institute for Biology of Aging, Germany
Short Talk: Autophagy Functions in Mitochondrial DNA Maintenance and Copy Number Regulation

Wednesday, April 25 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, April 25 | 11:15AM - 1:00PM
Poster Setup
Room: Mizuho


Wednesday, April 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Mizuho


Wednesday, April 25 | 2:30PM - 4:30PM
Workshop 2: Communication
Room: Mizuho

Speaker 1 of 9
* Adam L. Hughes, University of Utah, USA

Wednesday, April 25 | 2:30PM - 4:30PM
Workshop 2: Communication
Room: Mizuho

Speaker 2 of 9
Yusuke Hirabayashi, Columbia University, USA
ER-Mitochondria Tethering by PDZD8 Regulates Ca2+ Dynamics in Mammalian Neurons

Wednesday, April 25 | 2:30PM - 4:30PM
Workshop 2: Communication
Room: Mizuho

Speaker 3 of 9
Yvette C. Wong, Northwestern University, USA
Mitochondria-Lysosome Contacts Regulate Mitochondrial Fission via Rab7 GTP Hydrolysis

Wednesday, April 25 | 2:30PM - 4:30PM
Workshop 2: Communication
Room: Mizuho

Speaker 4 of 9
Thomas Ryan Hurd, New York University School of Medicine, USA
Mitochondrial Fragmentation Drives the Selective Removal of Deleterious Mitochondrial DNA in the Drosophila Germline

Wednesday, April 25 | 2:30PM - 4:30PM
Workshop 2: Communication
Room: Mizuho

Speaker 5 of 9
Lena Pernas, University of Padua, Italy
Mitochondria Limit Toxoplasma Growth by Competing for Fatty Acids

Wednesday, April 25 | 2:30PM - 4:30PM
Workshop 2: Communication
Room: Mizuho

Speaker 6 of 9
Keisuke Takeda, Tokyo University of Pharmacy and Life Sciences, Japan
MITOL Prevents ER Stress-Induced Apoptosis via IRE1a Ubiquitylation at ER-Mitochondria Contact Sites

Wednesday, April 25 | 2:30PM - 4:30PM
Workshop 2: Communication
Room: Mizuho

Speaker 7 of 9
Michal Turek, University of Warsaw, Poland
Spatial Relationship between Mitochondria and the Protein Quality Control System

Wednesday, April 25 | 2:30PM - 4:30PM
Workshop 2: Communication
Room: Mizuho

Speaker 8 of 9
Magali R. VanLinden, University of Bergen, Norway
Mitochondrial NAD is a Key Determinant of the Metabolic Profile of Human Cells and is Connected to the Peroxisomal NAD Pool

Wednesday, April 25 | 2:30PM - 4:30PM
Workshop 2: Communication
Room: Mizuho

Speaker 9 of 9
David A. Stroud, University of Melbourne, Australia
Systems Approaches to Understanding the Assembly of Mitochondrial Machines

Wednesday, April 25 | 4:30PM - 5:00PM
Coffee Available
Room: Mizuho Foyer


Wednesday, April 25 | 5:00PM - 7:15PM
Mitochondrial Communication I
Room: Mizuho

Speaker 1 of 6
* Orian S. Shirihai, University of California, Los Angeles, USA

Wednesday, April 25 | 5:00PM - 7:15PM
Mitochondrial Communication I
Room: Mizuho

Speaker 2 of 6
Gia K. Voeltz, University of Colorado Boulder, USA
ER-Linked Mitochondrial Division

Wednesday, April 25 | 5:00PM - 7:15PM
Mitochondrial Communication I
Room: Mizuho

Speaker 3 of 6
Jared Rutter, University of Utah, USA
Novel Mitochondrial Biochemistry

Wednesday, April 25 | 5:00PM - 7:15PM
Mitochondrial Communication I
Room: Mizuho

Speaker 4 of 6
Peter Walter, HHMI/University of California, San Francisco, USA
Signaling in the Unfolded Protein Response

Wednesday, April 25 | 5:00PM - 7:15PM
Mitochondrial Communication I
Room: Mizuho

Speaker 5 of 6
Peter Rehling, University Medical Centre Göttingen, Germany
Short Talk: Defective Mitochondrial Cardiolipin-Remodeling Dampens HIF1-alpha Transcription

Wednesday, April 25 | 5:00PM - 7:15PM
Mitochondrial Communication I
Room: Mizuho

Speaker 6 of 6
Jakob Daniel Busch, Max-Planck-Institute for Biology of Ageing, Germany
Short Talk: MitoRibo-Tag Mice to Study the Mitochondrial Ribosome in vivo

Wednesday, April 25 | 5:00PM - 7:00PM
Organellophagy Other than Mitophagy
This session is from Autophagy
Room: Yamashiro

Speaker 1 of 5
* Vojo Deretic, University of New Mexico Health Sciences Center, USA


Wednesday, April 25 | 5:00PM - 7:00PM
Organellophagy Other than Mitophagy
This session is from Autophagy
Room: Yamashiro

Speaker 2 of 5
Hitoshi Nakatogawa, Tokyo Institute of Technology, Japan
Molecular Mechanisms of Organellophagy in Yeast


Wednesday, April 25 | 5:00PM - 7:00PM
Organellophagy Other than Mitophagy
This session is from Autophagy
Room: Yamashiro

Speaker 3 of 5
Eric H. Baehrecke, University of Massachusetts Medical School, USA
Novel Regulators of Organelle Autophagy


Wednesday, April 25 | 5:00PM - 7:00PM
Organellophagy Other than Mitophagy
This session is from Autophagy
Room: Yamashiro

Speaker 4 of 5
Tamotsu Yoshimori, Osaka University, Japan
Dissection of Molecular Mechanisms in Lysophagy


Wednesday, April 25 | 5:00PM - 7:00PM
Organellophagy Other than Mitophagy
This session is from Autophagy
Room: Yamashiro

Speaker 5 of 5
Heeseon An, Harvard Medical School, USA
Short Talk: Systematic Analysis of Ribophagy in Human Cells Reveals Bystander Degradation during Selective Autophagy


Wednesday, April 25 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Mizuho
No registration fees are used to fund alcohol served at this function.

Wednesday, April 25 | 7:30PM - 10:00PM
Poster Session 3
Room: Mizuho


Thursday, April 26 | 7:30AM - 8:00AM
Poster Setup
Room: Mizuho


Thursday, April 26 | 8:00AM - 5:00PM
Poster Viewing
Room: Mizuho


Thursday, April 26 | 8:00AM - 11:15AM
Regulation of Mitochondrial Biogenesis
Room: Mizuho

Speaker 1 of 8
* Thomas Langer, CECAD Research Center, Germany

Thursday, April 26 | 8:00AM - 11:15AM
Regulation of Mitochondrial Biogenesis
Room: Mizuho

Speaker 2 of 8
Nikolaus Pfanner, University of Freiburg, Germany
Protein Biogenesis and Architecture of Mitochondria

Thursday, April 26 | 8:00AM - 11:15AM
Regulation of Mitochondrial Biogenesis
Room: Mizuho

Speaker 3 of 8
Elena I. Rugarli, University of Cologne, Germany
Post-Transcriptional Control of Mitochondrial Function

Thursday, April 26 | 8:00AM - 11:15AM
Regulation of Mitochondrial Biogenesis
Room: Mizuho


Coffee Break

Thursday, April 26 | 8:00AM - 11:15AM
Regulation of Mitochondrial Biogenesis
Room: Mizuho

Speaker 5 of 8
Brendan J. Battersby, University of Helsinki, Finland
Selective Mitochondrial Proteotoxicity Triggers a Stress Response on Membrane Dynamics and Ribosomes

Thursday, April 26 | 8:00AM - 11:15AM
Regulation of Mitochondrial Biogenesis
Room: Mizuho

Speaker 6 of 8
Eric A. Shoubridge, McGill University, Canada
Mitochondria 101: Mitochondrial Interaction Network

Thursday, April 26 | 8:00AM - 11:15AM
Regulation of Mitochondrial Biogenesis
Room: Mizuho

Speaker 7 of 8
Stefan Jakobs, Max Planck Institute for Biophysical Chemistry, Germany
Short Talk: Spatial Distribution of Mitochondrial Translation and OXPHOS Complex Assembly

Thursday, April 26 | 8:00AM - 11:15AM
Regulation of Mitochondrial Biogenesis
Room: Mizuho

Speaker 8 of 8
Sofia Zaganelli, University of Geneva, Switzerland
Short Talk: Identification of Mitochondrial RNA Granules Assembly Factors and Regulators using an Image-Based siRNA Screen

Thursday, April 26 | 8:00AM - 11:15AM
Endo-Lysosome System
This session is from Autophagy
Room: Yamashiro

Speaker 1 of 8
* Hitoshi Nakatogawa, Tokyo Institute of Technology, Japan


Thursday, April 26 | 8:00AM - 11:15AM
Endo-Lysosome System
This session is from Autophagy
Room: Yamashiro

Speaker 2 of 8
Noboru Mizushima, University of Tokyo, Japan
ATG Genes in Zebrafish and Mice


Thursday, April 26 | 8:00AM - 11:15AM
Endo-Lysosome System
This session is from Autophagy
Room: Yamashiro

Speaker 3 of 8
Marja Jäättelä, Danish Cancer Society Research Center, Denmark
Lysosomal STAT3 Regulates Intracellular Proton Equilibrium


Thursday, April 26 | 8:00AM - 11:15AM
Endo-Lysosome System
This session is from Autophagy
Room: Yamashiro


Coffee Break


Thursday, April 26 | 8:00AM - 11:15AM
Endo-Lysosome System
This session is from Autophagy
Room: Yamashiro

Speaker 5 of 8
Enrique J. Garcia, Columbia University, USA
Short Talk: ESCRT-Mediated Microlipophagy during Lipid Imbalance


Thursday, April 26 | 8:00AM - 11:15AM
Endo-Lysosome System
This session is from Autophagy
Room: Yamashiro

Speaker 6 of 8
Harald Stenmark, Oslo University Hospital, Norway
Lysosome Repair vs Lysophagy


Thursday, April 26 | 8:00AM - 11:15AM
Endo-Lysosome System
This session is from Autophagy
Room: Yamashiro

Speaker 7 of 8
Roberto Zoncu, University of California, Berkeley, USA
A Nutrient-Induced Affinity Switch Controls mTORC1 Capture by its Lysosomal Scaffold


Thursday, April 26 | 8:00AM - 11:15AM
Endo-Lysosome System
This session is from Autophagy
Room: Yamashiro

Speaker 8 of 8
Arnold Y. Seo, Janelia Research Campus, USA
Short Talk: Macroautophagy Enhanced by Mitochondrial Respiration Remodels Vacuole Liquid-Ordered Membrane Domain to Control Micro-Lipophagy


Thursday, April 26 | 11:15AM - 12:30PM
Lunch
Room: Mizuho


Thursday, April 26 | 12:30PM - 2:30PM
Poster Session 4
Room: Mizuho


Thursday, April 26 | 3:00PM - 4:30PM
Workshop 2
This session is from Autophagy
Room: Yamashiro

Speaker 1 of 6
* Tamotsu Yoshimori, Osaka University, Japan


Thursday, April 26 | 3:00PM - 4:30PM
Workshop 2
This session is from Autophagy
Room: Yamashiro

Speaker 2 of 6
Michael Joseph Munson, University of Oslo, Norway
The Regulation of Mitophagy by Lipid-Binding Proteins


Thursday, April 26 | 3:00PM - 4:30PM
Workshop 2
This session is from Autophagy
Room: Yamashiro

Speaker 3 of 6
Fumiyo Ikeda, IMBA – Institute of Molecular Biotechnology, Austria
The IAP Family Member BRUCE Regulates Autophagosome-Lysosome Fusion


Thursday, April 26 | 3:00PM - 4:30PM
Workshop 2
This session is from Autophagy
Room: Yamashiro

Speaker 4 of 6
Shigeomi Shimizu, Tokyo Medical and Dental University, Japan
Mechanisms and Biological Roles of Golgi-Stress-Induced Mitophagy


Thursday, April 26 | 3:00PM - 4:30PM
Workshop 2
This session is from Autophagy
Room: Yamashiro

Speaker 5 of 6
Martina B. Wirth, Francis Crick Institute, UK
Structural Determinants Mediating Selective Binding of Autophagy Adaptors and Receptors to Mammalian ATG8 Proteins


Thursday, April 26 | 3:00PM - 4:30PM
Workshop 2
This session is from Autophagy
Room: Yamashiro

Speaker 6 of 6
Elena Marcassa, University of Liverpool, UK
Regulation of Basal Mitophagy and Pexophagy by the Mitochondrial Deubiquitylase USP30


Thursday, April 26 | 4:30PM - 5:00PM
Coffee Available
Room: Mizuho Foyer


Thursday, April 26 | 5:00PM - 7:00PM
Mitochondrial Communication II
Room: Mizuho

Speaker 1 of 5
* Benoit Kornmann, ETH Zurich, Switzerland

Thursday, April 26 | 5:00PM - 7:00PM
Mitochondrial Communication II
Room: Mizuho

Speaker 2 of 5
Toshiya Endo, Kyoto Sangyo University, Japan
Mitochondrial Protein and Lipid Trafficking

Thursday, April 26 | 5:00PM - 7:00PM
Mitochondrial Communication II
Room: Mizuho

Speaker 3 of 5
William A. Prinz, NIDDK, National Institutes of Health, USA
Link between Lipid Synthesis and Transport to Mitochondria

Thursday, April 26 | 5:00PM - 7:00PM
Mitochondrial Communication II
Room: Mizuho

Speaker 4 of 5
Jodi Nunnari, University of California, Davis, USA
Mitochondrial Behavior

Thursday, April 26 | 5:00PM - 7:00PM
Mitochondrial Communication II
Room: Mizuho

Speaker 5 of 5
Christoph Uwe Mårtensson, University of Freiburg, Germany
Short Talk: Protein Quality Control at the Main Entry Gate for Precursor Proteins into Mitochondria

Thursday, April 26 | 5:00PM - 6:45PM
Therapeutic Regulation of Autophagy
This session is from Autophagy
Room: Yamashiro

Speaker 1 of 4
* Ai Yamamoto, Columbia University, USA


Thursday, April 26 | 5:00PM - 6:45PM
Therapeutic Regulation of Autophagy
This session is from Autophagy
Room: Yamashiro

Speaker 2 of 4
Jayanta Debnath, University of California, San Francisco, USA
NBR1, Selective Autophagy and Metastasis


Thursday, April 26 | 5:00PM - 6:45PM
Therapeutic Regulation of Autophagy
This session is from Autophagy
Room: Yamashiro

Speaker 3 of 4
Beat Nyfeler, Novartis Institutes for BioMedical Research, Switzerland
Phenotypic Screening Paradigms for Autophagy Pathway Regulators


Thursday, April 26 | 5:00PM - 6:45PM
Therapeutic Regulation of Autophagy
This session is from Autophagy
Room: Yamashiro

Speaker 4 of 4
Noriyuki Matsuda, Tokyo Metropolitan Institute of Medical Science, Japan
Mitochondria Quality Control Elucidated from Parkinson's Disease


Thursday, April 26 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Autophagy
Room: Yamashiro


Thursday, April 26 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Mizuho


Thursday, April 26 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Mizuho
No registration fees are used to fund alcohol served at this function.

Thursday, April 26 | 8:00PM - 9:00PM
Entertainment
Room: Mizuho
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, April 26 | 8:00PM - 9:00PM
Cash Bar
Room: Mizuho


Friday, April 27 | 10:24AM - 10:24AM
Departure


*Session Chair.