Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
	Neurodegenerative Diseases: New Insights and Therapeutic Opportunities (2019Z2)

Web Desc
Advances in Neurodegenerative Disease Research and Therapy joint with New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? Organizer(s): Li Gan, Leonard Petrucelli and Morgan H. Sheng Date: June 17 - 21, 2018 Location: Keystone Resort, Keystone, CO, USA Sponsored by Ionis Pharmaceuticals, Inc., Merck & Co., Inc., Nestlé Institute of Health Sciences, Roche and Takeda Pharmaceutical Company Limited Summary of Meeting: As the world population ages, neurodegenerative diseases are becoming the new epidemic in both developed and developing countries. Progress made in human genetics has revealed increasingly more disease-associated genes for Alzheimer’s disease (AD), Parkinson’s disease (PD), Frontotemoral dementia (FTD), amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. These discoveries have linked neurodegenerative diseases with several common key biological processes that have so far been under-studied, including RNA metabolism, protein trafficking and innate immune responses. By focusing on these emerging areas in neurodegenerative disease research, this conference seeks to challenge the current research paradigms and to inspire in-depth discussion and exploration. The program assembles leaders from various fields to facilitate interactions between groups using diverse approaches, by providing a platform to cross-fertilize ideas and to encourage new collaborations that could lead to novel mechanisms and therapeutic targets against neurodegenerative diseases. Scholarship Deadline: February 15 2018 Discounted Abstract Deadline: February 15 2018 Abstract Deadline: March 15 2018 Discounted Registration Deadline: April 18 2018 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support from these exhibitors at this conference: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Ionis Pharmaceuticals, Inc. Sanofi US We gratefully acknowledge the generous grant for this conference provided by: National Institute of Neurological Disorders and Stroke (NINDS) Grant No. 1R13NS106977-01 Funding for this conference was made possible (in part) by 1R13NS106977-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Advances in Neurodegenerative Disease Research and Therapy

joint with New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet?

Organizer(s): Li Gan, Leonard Petrucelli and Morgan H. Sheng

Date: June 17 - 21, 2018
Location: Keystone Resort, Keystone, CO, USA

Sponsored by Ionis Pharmaceuticals, Inc., Merck & Co., Inc., Nestlé Institute of Health Sciences, Roche and Takeda Pharmaceutical Company Limited

Summary of Meeting:

As the world population ages, neurodegenerative diseases are becoming the new epidemic in both developed and developing countries. Progress made in human genetics has revealed increasingly more disease-associated genes for Alzheimer’s disease (AD), Parkinson’s disease (PD), Frontotemoral dementia (FTD), amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. These discoveries have linked neurodegenerative diseases with several common key biological processes that have so far been under-studied, including RNA metabolism, protein trafficking and innate immune responses. By focusing on these emerging areas in neurodegenerative disease research, this conference seeks to challenge the current research paradigms and to inspire in-depth discussion and exploration. The program assembles leaders from various fields to facilitate interactions between groups using diverse approaches, by providing a platform to cross-fertilize ideas and to encourage new collaborations that could lead to novel mechanisms and therapeutic targets against neurodegenerative diseases.

Scholarship Deadline: February 15 2018

Discounted Abstract Deadline: February 15 2018

Abstract Deadline: March 15 2018

Discounted Registration Deadline: April 18 2018

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support from these exhibitors at this conference:

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Ionis Pharmaceuticals, Inc.

Sanofi US

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS106977-01
Funding for this conference was made possible (in part) by 1R13NS106977-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, June 17 \| 4:00PM - 8:00PM Arrival and Registration Room: Longs Peak Foyer
Sunday, June 17 \| 6:00PM - 8:00PM Welcome Mixer Room: Longs Peak Foyer No registration fees are used to fund alcohol served at this function.
Monday, June 18 \| 7:30AM - 8:30AM Breakfast Room: Colorado Rockies Ballroom
Monday, June 18 \| 8:30AM - 9:30AM Welcome and Keynote Address Room: Quandary Peak Speaker 1 of 2 * Li Gan, Weill Cornell Medicine, USA
Monday, June 18 \| 8:30AM - 9:30AM Welcome and Keynote Address Room: Quandary Peak Speaker 2 of 2 Huda Y. Zoghbi, HHMI/Baylor College of Medicine, USA Insights From Rare Disorders Shed Light on Common Neurodegenerative Diseases
Monday, June 18 \| 9:30AM - 12:00PM Genetics to Epigenetics in Neurodegenerative Diseases Room: Quandary Peak Speaker 1 of 7 * Leonard Petrucelli, Mayo Clinic Jacksonville, USA
Monday, June 18 \| 9:30AM - 12:00PM Genetics to Epigenetics in Neurodegenerative Diseases Room: Quandary Peak Speaker 2 of 7 John Hardy, University College London, Institute of Neurology, UK Genomics and Pathways to Neurodegeneration
Monday, June 18 \| 9:30AM - 12:00PM Genetics to Epigenetics in Neurodegenerative Diseases Room: Quandary Peak Coffee Break
Monday, June 18 \| 9:30AM - 12:00PM Genetics to Epigenetics in Neurodegenerative Diseases Room: Quandary Peak Speaker 4 of 7 Catherine Marquer, Columbia University, USA Short Talk: Excess Synaptojanin 1 Drives Age-Dependent Cognitive Deficits, a Unifying Mechanism for Individuals at High Risk of Alzheimer's Disease
Monday, June 18 \| 9:30AM - 12:00PM Genetics to Epigenetics in Neurodegenerative Diseases Room: Quandary Peak Speaker 5 of 7 Alison Goate, Icahn School of Medicine at Mount Sinai, USA Genetic Studies Implicate Microglial Function in Alzheimer's Disease Risk
Monday, June 18 \| 9:30AM - 12:00PM Genetics to Epigenetics in Neurodegenerative Diseases Room: Quandary Peak Speaker 6 of 7 Li-Huei Tsai, Massachusetts Institute of Technology, USA Transcriptomic Analysis at Single Cell Resolution in Neurodegeneration
Monday, June 18 \| 9:30AM - 12:00PM Genetics to Epigenetics in Neurodegenerative Diseases Room: Quandary Peak Speaker 7 of 7 John D. Fryer, Mayo Clinic, USA Short Talk: Translational Profiling of Microglia Reveals a Shared apoE Pathway Common to Aging, Amyloid and Tau Pathology
Monday, June 18 \| 9:30AM - 12:00PM Immune Privilege, Blood-Brain Barrier and Microglia I This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 1 of 7 * Knut Biber, AbbVie Deutschland GmbH & Co. KG, Germany
Monday, June 18 \| 9:30AM - 12:00PM Immune Privilege, Blood-Brain Barrier and Microglia I This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 2 of 7 Josef Priller, Charité – Universitätsmedizin Berlin, Germany From Bone Marrow to Brain: How Myeloid Cells Can Enter the CNS
Monday, June 18 \| 9:30AM - 12:00PM Immune Privilege, Blood-Brain Barrier and Microglia I This session is from Neuroinflammation Room: Grays/Longs Peak Coffee Break
Monday, June 18 \| 9:30AM - 12:00PM Immune Privilege, Blood-Brain Barrier and Microglia I This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 4 of 7 Jonathan Kipnis, Washington University School of Medicine, USA Lymphatics in the CNS and Their Role in Neurological Diseases
Monday, June 18 \| 9:30AM - 12:00PM Immune Privilege, Blood-Brain Barrier and Microglia I This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 5 of 7 Richard Daneman, University of California, San Diego, USA Regulation of the Blood-Brain Barrier in Health and Disease
Monday, June 18 \| 9:30AM - 12:00PM Immune Privilege, Blood-Brain Barrier and Microglia I This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 6 of 7 Karen De Vlaminck, Vrije Universiteit Brussel, Belgium Short Talk: The Fate and Dynamics of Microglia, Border Macrophages and Infiltrating Monocytes during the Onset and Resolution of Infectious Neuroinflammation
Monday, June 18 \| 9:30AM - 12:00PM Immune Privilege, Blood-Brain Barrier and Microglia I This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 7 of 7 Cayce Dorrier, University of California, San Diego, USA Short Talk: The Role of the Fibrotic Scar in Repair following Neuroinflammation
Monday, June 18 \| 12:00PM - 5:00PM On Own for Lunch
Monday, June 18 \| 12:00PM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Monday, June 18 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Monday, June 18 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, June 18 \| 5:00PM - 7:00PM Aging in Health and Disease Room: Quandary Peak Speaker 1 of 5 * Morgan H. Sheng, Broad Institute, USA
Monday, June 18 \| 5:00PM - 7:00PM Aging in Health and Disease Room: Quandary Peak Speaker 2 of 5 Andrew G. Dillin, University of California, Berkeley, USA Aging in Protein, Homeostasis and Stress
Monday, June 18 \| 5:00PM - 7:00PM Aging in Health and Disease Room: Quandary Peak Speaker 3 of 5 Ana Maria Cuervo, Albert Einstein College of Medicine, USA Contribution of Aging of Selective Autophagy to Neurodegeneration
Monday, June 18 \| 5:00PM - 7:00PM Aging in Health and Disease Room: Quandary Peak Speaker 4 of 5 Tony Wyss-Coray, Stanford University School of Medicine, USA Dissecting the Role of Cerebrovascular Dysfunction in Brain Aging
Monday, June 18 \| 5:00PM - 7:00PM Aging in Health and Disease Room: Quandary Peak Speaker 5 of 5 Edward Giniger, NINDS, National Institutes of Health, USA Short Talk: Separating the Roles of Autophagy, Immunity and Aging in Neurodegeneration
Monday, June 18 \| 5:00PM - 7:00PM Immune Privilege, Blood-Brain Barrier and Microglia II This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 1 of 5 * Bart J.L. Eggen, University Medical Center Groningen, Netherlands
Monday, June 18 \| 5:00PM - 7:00PM Immune Privilege, Blood-Brain Barrier and Microglia II This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 2 of 5 Marco Prinz, University of Freiburg, Germany Myeloid Cell Activation and Kinetics in the Brain
Monday, June 18 \| 5:00PM - 7:00PM Immune Privilege, Blood-Brain Barrier and Microglia II This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 3 of 5 Doron Merkler, University of Geneva, Switzerland Interaction between Neurons, Phagocytes and T Cells in Neuroinflammation
Monday, June 18 \| 5:00PM - 7:00PM Immune Privilege, Blood-Brain Barrier and Microglia II This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 4 of 5 Michal Schwartz, Weizmann Institute of Science, Israel Fighting Alzheimer's Disease by Unleashing the Innate and Adaptive Immune Cells
Monday, June 18 \| 5:00PM - 7:00PM Immune Privilege, Blood-Brain Barrier and Microglia II This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 5 of 5 Zhen Xu, Shenzhen University, China Short Talk: Repopulated Microglia Are Solely Derived from the Proliferation of Residual Microglia after Acute Depletion
Monday, June 18 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Monday, June 18 \| 7:30PM - 10:00PM Poster Session 1 Room: Colorado Rockies Ballroom
Tuesday, June 19 \| 7:30AM - 8:30AM Breakfast Room: Colorado Rockies Ballroom
Tuesday, June 19 \| 8:30AM - 11:45AM Innate Immunity Room: Quandary Peak Speaker 1 of 8 * David M. Holtzman, Washington University, USA
Tuesday, June 19 \| 8:30AM - 11:45AM Innate Immunity Room: Quandary Peak Speaker 2 of 8 Adriano M. Aguzzi, University Hospital of Zürich, Switzerland Protein Aggregation and Pathways of Toxicity
Tuesday, June 19 \| 8:30AM - 11:45AM Innate Immunity Room: Quandary Peak Speaker 3 of 8 Christian Haass, Ludwig-Maximilians University Munich, Germany Loss of TREM2 Function Increases Amyloid Seeding but Reduces Plaque-Associated ApoE
Tuesday, June 19 \| 8:30AM - 11:45AM Innate Immunity Room: Quandary Peak Speaker 4 of 8 Matthew A. Cooper, University of Queensland, Australia Short Talk: Pharmacological Inhibition of the NLRP3 Inflammasome Prevents Synuclein Pathology and Dopaminergic Degeneration in Parkinson's Disease
Tuesday, June 19 \| 8:30AM - 11:45AM Innate Immunity Room: Quandary Peak Coffee Break
Tuesday, June 19 \| 8:30AM - 11:45AM Innate Immunity Room: Quandary Peak Speaker 6 of 8 Christopher K. Glass, University of California, San Diego, USA Genomic Approaches to Dissect Innate Immunity in Neurodegeneration
Tuesday, June 19 \| 8:30AM - 11:45AM Innate Immunity Room: Quandary Peak Speaker 7 of 8 Li Gan, Weill Cornell Medicine, USA Microglia in Tau Proteostasis and Toxicity
Tuesday, June 19 \| 8:30AM - 11:45AM Innate Immunity Room: Quandary Peak Speaker 8 of 8 Andrew B. West, University of Alabama at Birmingham, USA Short Talk: LRRK2 Mediates the Recruitment of Monocyte-Derived Macrophages to the Brain in Neurodegeneration
Tuesday, June 19 \| 8:30AM - 11:45AM Cross-Talk of Microglia with Other CNS Cells This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 1 of 8 * Katrin Kierdorf, Uniklinik Freiburg, Germany
Tuesday, June 19 \| 8:30AM - 11:45AM Cross-Talk of Microglia with Other CNS Cells This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 2 of 8 Mikael Simons, Technische Universität München, Germany Cholesterol Metabolisms as Key Regulator of Phagocyte Function during Remyelination
Tuesday, June 19 \| 8:30AM - 11:45AM Cross-Talk of Microglia with Other CNS Cells This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 3 of 8 Francisco J. Quintana, Harvard Medical School, USA Astrocytes and Microglia
Tuesday, June 19 \| 8:30AM - 11:45AM Cross-Talk of Microglia with Other CNS Cells This session is from Neuroinflammation Room: Grays/Longs Peak Coffee Break
Tuesday, June 19 \| 8:30AM - 11:45AM Cross-Talk of Microglia with Other CNS Cells This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 5 of 8 Anna Victoria Molofsky, University of California, San Francisco, USA Astrocyte-Microglial Communication in Developmental Synapse Remodeling
Tuesday, June 19 \| 8:30AM - 11:45AM Cross-Talk of Microglia with Other CNS Cells This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 6 of 8 Burkhard Becher, University of Zurich, Switzerland T Cell Entry into the CNS: How Myelin Is Presented
Tuesday, June 19 \| 8:30AM - 11:45AM Cross-Talk of Microglia with Other CNS Cells This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 7 of 8 Courtney Malo, NIAID, National Institutes of Health, USA Short Talk: MHC Class I Expression by Microglia Is Required for Generating a Complete Antigen-Specific CD8 T Cell Response in the CNS
Tuesday, June 19 \| 8:30AM - 11:45AM Cross-Talk of Microglia with Other CNS Cells This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 8 of 8 Phi T. Nguyen, University of California, San Francisco, USA Short Talk: The IL-33-IL1RL1 Signaling Axis Coordinates Remodeling and Integration of Adult-Born Neurons in the Hippocampus
Tuesday, June 19 \| 11:45AM - 5:00PM On Own for Lunch
Tuesday, June 19 \| 11:45AM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Tuesday, June 19 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Tuesday, June 19 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, June 19 \| 5:00PM - 7:00PM Neuronal and Network Dysfunction in Neurodegeneration Room: Quandary Peak Speaker 1 of 5 * Li-Huei Tsai, Massachusetts Institute of Technology, USA
Tuesday, June 19 \| 5:00PM - 7:00PM Neuronal and Network Dysfunction in Neurodegeneration Room: Quandary Peak Speaker 2 of 5 Huaxi Xu, Sanford Burnham Prebys Medical Discovery Institute, USA A Novel Mechanism for Memory/Synaptic Dysfunction in Tauopathy
Tuesday, June 19 \| 5:00PM - 7:00PM Neuronal and Network Dysfunction in Neurodegeneration Room: Quandary Peak Speaker 3 of 5 Zayd M. Khaliq, NINDS, National Institutes of Health, USA Dendritic Ca2+ Signaling in Substantia Nigra Dopamine Neuron Subpopulations
Tuesday, June 19 \| 5:00PM - 7:00PM Neuronal and Network Dysfunction in Neurodegeneration Room: Quandary Peak Speaker 4 of 5 Morgan H. Sheng, Broad Institute, USA Mechanisms of Synapse Loss Revealed by Proteomic Analysis of Post-Synaptic Density in Tauopathy Mouse Model
Tuesday, June 19 \| 5:00PM - 7:00PM Neuronal and Network Dysfunction in Neurodegeneration Room: Quandary Peak Speaker 5 of 5 Keran Ma, University of California, San Francisco, USA Short Talk: Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease
Tuesday, June 19 \| 5:00PM - 7:00PM Myeloid Cells and Neuroinflammation This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 1 of 5 * Erik H.W.G.M. Boddeke, University of Groningen, Netherlands
Tuesday, June 19 \| 5:00PM - 7:00PM Myeloid Cells and Neuroinflammation This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 2 of 5 Masaaki Murakami, Hokkaido University, Japan Neural Stimulations Modulate the Formation of Immune Cell Gateways into the CNS
Tuesday, June 19 \| 5:00PM - 7:00PM Myeloid Cells and Neuroinflammation This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 3 of 5 Akihiko Yoshimura, Keio University, Japan Regulation of Inflammation after Stroke by Macrophages and Regulatory T Cells
Tuesday, June 19 \| 5:00PM - 7:00PM Myeloid Cells and Neuroinflammation This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 4 of 5 Robyn S. Klein, Washington University School of Medicine, USA Trm-Derived IFNg Causes Microglial-Mediated Spatial Learning Defects during Recovery from Differentially Neurotropic Flaviviruses
Tuesday, June 19 \| 5:00PM - 7:00PM Myeloid Cells and Neuroinflammation This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 5 of 5 Kevin G. Burfeind, Oregon Health & Science University, USA Short Talk: Infiltrating Myeloid Cells in the Central Nervous System Mediate Cancer Cachexia
Tuesday, June 19 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Tuesday, June 19 \| 7:30PM - 10:00PM Poster Session 2 Room: Colorado Rockies Ballroom
Wednesday, June 20 \| 7:30AM - 8:30AM Breakfast Room: Colorado Rockies Ballroom
Wednesday, June 20 \| 8:30AM - 11:45AM Protein Trafficking and Degradation Room: Quandary Peak Speaker 1 of 9 * Tony Wyss-Coray, Stanford University School of Medicine, USA
Wednesday, June 20 \| 8:30AM - 11:45AM Protein Trafficking and Degradation Room: Quandary Peak Speaker 2 of 9 Baris Bingol, Genentech, Inc., USA Lysosomal Degradation in Parkinson’s Disease
Wednesday, June 20 \| 8:30AM - 11:45AM Protein Trafficking and Degradation Room: Quandary Peak Speaker 3 of 9 Guojun Bu, Mayo Clinic, USA Central and Peripheral ApoE4 in Cognition and Dementia
Wednesday, June 20 \| 8:30AM - 11:45AM Protein Trafficking and Degradation Room: Quandary Peak Speaker 4 of 9 Michael E. Ward, NINDS, National Institutes of Health, USA Short Talk: Progranulin Mediates Endolysosomal Recruitment of the RNP-Associated Protein ANXA11
Wednesday, June 20 \| 8:30AM - 11:45AM Protein Trafficking and Degradation Room: Quandary Peak Coffee Break
Wednesday, June 20 \| 8:30AM - 11:45AM Protein Trafficking and Degradation Room: Quandary Peak Speaker 6 of 9 David M. Holtzman, Washington University, USA Effects of ApoE in Tau-Mediated Neurodegeneration
Wednesday, June 20 \| 8:30AM - 11:45AM Protein Trafficking and Degradation Room: Quandary Peak Speaker 7 of 9 Jaehong Suh, Massachusetts General Hospital / Harvard Medical School, USA Short Talk: Role of Ataxin-1 in BACE1 Expression and Axonal Targeting in the Cerebrum
Wednesday, June 20 \| 8:30AM - 11:45AM Protein Trafficking and Degradation Room: Quandary Peak Speaker 8 of 9 R. Jeremy Nichols, Parkinson's Institute, USA Short Talk: SQSTM1/p62 Is a Novel Substrate of the Parkinson's Disease Kinase LRRK2 that Activates its Kinase Domain and Enhances Neuronal Toxicity
Wednesday, June 20 \| 8:30AM - 11:45AM Protein Trafficking and Degradation Room: Quandary Peak Speaker 9 of 9 Naruhiko Sahara, National Institute of Radiological Sciences, Japan Short Talk: Neuroinflammatory Process during Pathogenesis of Tauopathy in rTg4510 Mice
Wednesday, June 20 \| 8:30AM - 11:45AM Imaging of the Healthy and Diseased CNS This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 1 of 8 * Sophia Bardehle, Merck, USA
Wednesday, June 20 \| 8:30AM - 11:45AM Imaging of the Healthy and Diseased CNS This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 2 of 8 Wenbiao Gan, Skirball Institute Program of Molecular Neurobiology, USA The Role of Microglia in Learning-Dependent Synaptic Plasticity
Wednesday, June 20 \| 8:30AM - 11:45AM Imaging of the Healthy and Diseased CNS This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 3 of 8 Martin Kerschensteiner, Ludwig Maximilians University Munich, Germany In vivo Analysis of Phagocyte Phenotypes and Effector Function
Wednesday, June 20 \| 8:30AM - 11:45AM Imaging of the Healthy and Diseased CNS This session is from Neuroinflammation Room: Grays/Longs Peak Coffee Break
Wednesday, June 20 \| 8:30AM - 11:45AM Imaging of the Healthy and Diseased CNS This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 5 of 8 Melanie Meyer-Luehmann, University of Freiburg, Germany Microglia Contribution to the Propagation of Abeta Pathology
Wednesday, June 20 \| 8:30AM - 11:45AM Imaging of the Healthy and Diseased CNS This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 6 of 8 Francesca Peri, European Molecular Biology Laboratory, Germany Microglia and Neuronal Interactions
Wednesday, June 20 \| 8:30AM - 11:45AM Imaging of the Healthy and Diseased CNS This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 7 of 8 Anna Mechling, Roche Innovation Center Basel, Hoffmann-La Roche Ltd., Switzerland Short Talk: Pivotal Role of Microglial TREM2 in Remyelination as Revealed by Multiparametric Magnetic Resonance Imaging in the Cuprizone Mouse Model
Wednesday, June 20 \| 8:30AM - 11:45AM Imaging of the Healthy and Diseased CNS This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 8 of 8 Vijayasree V. Giridharan, University of Texas Health Science Center, USA Short Talk: Imaging of Microglial Activation in Experimental Bacterial Meningitis using PET/CT
Wednesday, June 20 \| 11:45AM - 5:00PM On Own for Lunch
Wednesday, June 20 \| 11:45AM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Wednesday, June 20 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Wednesday, June 20 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, June 20 \| 5:00PM - 7:00PM Disease Modeling Room: Quandary Peak Speaker 1 of 5 * Jeffrey D. Rothstein, Johns Hopkins University, USA
Wednesday, June 20 \| 5:00PM - 7:00PM Disease Modeling Room: Quandary Peak Speaker 2 of 5 Leslie M. Thompson, University of California, Irvine, USA A Systems Biology Approach to Understanding ALS Pathogenesis in iPSC-Derived Motor Neurons
Wednesday, June 20 \| 5:00PM - 7:00PM Disease Modeling Room: Quandary Peak Speaker 3 of 5 Albert R. La Spada, Duke University, USA Deconstructing Polyglutamine Neurodegeneration: From Pathways of Neuron Demise to Therapeutic Intervention
Wednesday, June 20 \| 5:00PM - 7:00PM Disease Modeling Room: Quandary Peak Speaker 4 of 5 Yadong Huang, Gladstone Institutes/UCSF, USA Modeling and Drug Screening of AD Using Patients-Derived iPSCs
Wednesday, June 20 \| 5:00PM - 7:00PM Disease Modeling Room: Quandary Peak Speaker 5 of 5 Michael Lee, University of Minnesota, USA Short Talk: Dissociation of Amyloid Dependent Cognitive Deficits and Neurodegeneration
Wednesday, June 20 \| 5:00PM - 7:00PM Myeloid Cells as Targets of Drug Discovery and Biomarkers This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 1 of 4 * Andrea Crotti, Astellas Pharma, USA
Wednesday, June 20 \| 5:00PM - 7:00PM Myeloid Cells as Targets of Drug Discovery and Biomarkers This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 2 of 4 Irene Knuesel, Roche Innovation Center Basel, Switzerland Therapeutic Effects of Anti-Amyloid-Beta Immunotherapy on Myeloid Cell Transcriptome
Wednesday, June 20 \| 5:00PM - 7:00PM Myeloid Cells as Targets of Drug Discovery and Biomarkers This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 3 of 4 David R. Owen, Imperial College London, UK Imaging Microglia in Humans
Wednesday, June 20 \| 5:00PM - 7:00PM Myeloid Cells as Targets of Drug Discovery and Biomarkers This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 4 of 4 Paul R. Ormel, University Medical Center Utrecht, Netherlands Short Talk: Comparison of Three Human Microglia Models to Study Schizophrenia
Wednesday, June 20 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Wednesday, June 20 \| 7:30PM - 10:00PM Poster Session 3 Room: Colorado Rockies Ballroom
Thursday, June 21 \| 7:30AM - 8:30AM Breakfast Room: Colorado Rockies Ballroom
Thursday, June 21 \| 8:30AM - 11:45AM RNA Metabolisms and New Mechanisms of Toxicity Room: Quandary Peak Speaker 1 of 9 * Yadong Huang, Gladstone Institutes/UCSF, USA
Thursday, June 21 \| 8:30AM - 11:45AM RNA Metabolisms and New Mechanisms of Toxicity Room: Quandary Peak Speaker 2 of 9 Wolfdieter Springer, Mayo Clinic, USA Short Talk: Relevance of PINK1-Parkin Mitophagy in Stress, Aging and Disease
Thursday, June 21 \| 8:30AM - 11:45AM RNA Metabolisms and New Mechanisms of Toxicity Room: Quandary Peak Speaker 3 of 9 Christopher D. Link, University of Colorado, USA Short Talk: Knockdown of TDP-43 in Astrocytes Induces Immune Activation
Thursday, June 21 \| 8:30AM - 11:45AM RNA Metabolisms and New Mechanisms of Toxicity Room: Quandary Peak Speaker 4 of 9 Jeffrey D. Rothstein, Johns Hopkins University, USA Nuclear Transport as an Unexpected Fundamental Defect in Familial and Sporadic Neurodegeneration
Thursday, June 21 \| 8:30AM - 11:45AM RNA Metabolisms and New Mechanisms of Toxicity Room: Quandary Peak Speaker 5 of 9 Zevik Melamed, University of California, San Diego, USA Short Talk: RNA Processing Alteration and the Link to Neurodegeneration in ALS/FTD
Thursday, June 21 \| 8:30AM - 11:45AM RNA Metabolisms and New Mechanisms of Toxicity Room: Quandary Peak Coffee Break
Thursday, June 21 \| 8:30AM - 11:45AM RNA Metabolisms and New Mechanisms of Toxicity Room: Quandary Peak Speaker 7 of 9 Leonard Petrucelli, Mayo Clinic Jacksonville, USA C9 Biology and Biomarkers
Thursday, June 21 \| 8:30AM - 11:45AM RNA Metabolisms and New Mechanisms of Toxicity Room: Quandary Peak Speaker 8 of 9 Bess Frost, Barshop Institute for Longevity and Aging Studies, USA Jump Around, Jump Around: Transposable Element Activation in Tauopathy
Thursday, June 21 \| 8:30AM - 11:45AM RNA Metabolisms and New Mechanisms of Toxicity Room: Quandary Peak Speaker 9 of 9 Xin Qi, Case Western Reserve University, USA Short Talk: ATAD3A Oligomerization Causes Neurodegeneration by Coupling Mitochondrial Fragmentation and Bioenergetics Defects
Thursday, June 21 \| 8:30AM - 11:45AM Myeloid Gene Regulation This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 1 of 8 * Inge R. Holtman, University of California, San Diego, USA
Thursday, June 21 \| 8:30AM - 11:45AM Myeloid Gene Regulation This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 2 of 8 Oleg Butovsky, Harvard Medical School, USA Dual Faces of Dr. Jekyll Microglia: Degenerating Neurons Cannot 'Hyde'
Thursday, June 21 \| 8:30AM - 11:45AM Myeloid Gene Regulation This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 3 of 8 Ido Amit, Weizmann Institute, Israel The Power of ONE: Immunology in the Age of Single Cell Genomics
Thursday, June 21 \| 8:30AM - 11:45AM Myeloid Gene Regulation This session is from Neuroinflammation Room: Grays/Longs Peak Coffee Break
Thursday, June 21 \| 8:30AM - 11:45AM Myeloid Gene Regulation This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 5 of 8 Marco Colonna, Washington University School of Medicine, USA TREM2, Microglia and Neurodegeneration
Thursday, June 21 \| 8:30AM - 11:45AM Myeloid Gene Regulation This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 6 of 8 Bahareh Ajami, Stanford University School of Medicine, USA Single-Cell Mass Cytometry Reveals Molecular Signatures of Inflammation in Contrasting Models of Neuroinflammation versus Neurodegeneration
Thursday, June 21 \| 8:30AM - 11:45AM Myeloid Gene Regulation This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 7 of 8 Kendra Lechtenberg, Stanford University, USA Short Talk: Profiling Microglia-Specific Transcriptional Changes after Ischemic Stroke
Thursday, June 21 \| 8:30AM - 11:45AM Myeloid Gene Regulation This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 8 of 8 Carole Lara Veiga Sousa, Luxembourg Institute of Health, Luxembourg Short Talk: Molecular Profiling of Microglia in Steady State and Under Inflammatory Conditions at Single-Cell Level
Thursday, June 21 \| 11:45AM - 5:00PM On Own for Lunch
Thursday, June 21 \| 2:30PM - 4:30PM Workshop: Systems Approach and Functional Genomics Room: Quandary Peak Speaker 1 of 7 * Martin Kampmann, University of California, San Francisco, USA Elucidating Cellular Mechanisms and Therapeutic Strategies for Neurodegenerative Diseases with CRISPRi and CRISPRa
Thursday, June 21 \| 2:30PM - 4:30PM Workshop: Systems Approach and Functional Genomics Room: Quandary Peak Speaker 2 of 7 Taisuke Kato, Niigata University, Japan Phenotypic Suppression of DRPLA Model Mice using CRISPR / Cas9 System
Thursday, June 21 \| 2:30PM - 4:30PM Workshop: Systems Approach and Functional Genomics Room: Quandary Peak Speaker 3 of 7 Jiyoen Kim, Baylor College of Medicine, USA Identifying Therapeutic Targets for Alzheimer's Disease: A Cross-Species Genetic Screen for Molecules that Lower Tau Levels
Thursday, June 21 \| 2:30PM - 4:30PM Workshop: Systems Approach and Functional Genomics Room: Quandary Peak Speaker 4 of 7 Alan E. Renton, Icahn School of Medicine at Mount Sinai, USA Alzheimer's Disease Sequencing Project: Age Extremes x APOE Genotype Sampling for Genetic Discovery
Thursday, June 21 \| 2:30PM - 4:30PM Workshop: Systems Approach and Functional Genomics Room: Quandary Peak Speaker 5 of 7 Tara E. Tracy, University of California, San Francisco, USA Spatiotemporal Mapping of the Tau Interactome in Human iPSC-Derived Neurons
Thursday, June 21 \| 2:30PM - 4:30PM Workshop: Systems Approach and Functional Genomics Room: Quandary Peak Speaker 6 of 7 Tal Nuriel, Columbia University Medical Center, USA Utilizing Systems Biology Approaches to Elucidate the Effects of APOE4 Expression in an AD-Vulnerable Brain Region
Thursday, June 21 \| 2:30PM - 4:30PM Workshop: Systems Approach and Functional Genomics Room: Quandary Peak Speaker 7 of 7 Rakshita A. Charan, University of Pennsylvania, USA Identification and Characterization of Frontotemporal Dementia Risk Factor TMEM106B Interacting Proteins
Thursday, June 21 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, June 21 \| 5:00PM - 7:00PM Biomarker and Therapeutics Room: Quandary Peak Speaker 1 of 6 * Li Gan, Weill Cornell Medicine, USA
Thursday, June 21 \| 5:00PM - 7:00PM Biomarker and Therapeutics Room: Quandary Peak Speaker 2 of 6 David V. Hansen, Genentech, Inc., USA Short Talk: Assessing and Modulating Microglial Activation States in Alzheimer’s Disease Tissues and Models
Thursday, June 21 \| 5:00PM - 7:00PM Biomarker and Therapeutics Room: Quandary Peak Speaker 3 of 6 Xu Chen, Gladstone Institute of Neurological Disease, USA Short Talk: Tau Secretion and Propagation is Regulated by p300/CBP via Autophagy-Lysosomal Pathway
Thursday, June 21 \| 5:00PM - 7:00PM Biomarker and Therapeutics Room: Quandary Peak Speaker 4 of 6 C. Frank Bennett, Ionis Pharmaceuticals, Inc., USA Antisense Oligonucleotide-Based Therapies for Neurological Diseases
Thursday, June 21 \| 5:00PM - 7:00PM Biomarker and Therapeutics Room: Quandary Peak Speaker 5 of 6 Rita Balice-Gordon, Sanofi, Inc., USA Translational Challenges in Neuroscience Drug Development
Thursday, June 21 \| 5:00PM - 7:00PM Biomarker and Therapeutics Room: Quandary Peak Speaker 6 of 6 Tracy Cole, Ionis Pharmaceuticals, Inc., USA Short Talk: Human SNCA Antisense Oligonucleotides Reduce CNS and CSF Alpha-Synuclein Levels in a Non-Human Primate Model, Supporting their Use for Treatment of Synucleinopathies
Thursday, June 21 \| 5:00PM - 6:45PM Microglia and CNS Diseases This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 1 of 4 * Annett Halle, German Center for Neurodegenerative Diseases, Germany
Thursday, June 21 \| 5:00PM - 6:45PM Microglia and CNS Diseases This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 2 of 4 Shane Antony Liddelow, New York University Langone Medical Center, USA What Do Reactive Astrocytes Do?
Thursday, June 21 \| 5:00PM - 6:45PM Microglia and CNS Diseases This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 3 of 4 Florent Ginhoux, Singapore Immunology Network, Singapore Microglia Heterogeneity
Thursday, June 21 \| 5:00PM - 6:45PM Microglia and CNS Diseases This session is from Neuroinflammation Room: Grays/Longs Peak Speaker 4 of 4 Philip L. De Jager, Columbia University Medical Center, USA The Genetic and Population Architecture of Aged Human Microglia: Role in Accelerating Tau Pathology and Cognitive Decline
Thursday, June 21 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) This session is from Neuroinflammation Room: Grays/Longs Peak
Thursday, June 21 \| 7:00PM - 7:15PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Quandary Peak
Thursday, June 21 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Thursday, June 21 \| 8:00PM - 11:00PM Entertainment Room: Colorado Rockies Ballroom Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, June 21 \| 8:00PM - 11:00PM Cash Bar Room: Colorado Rockies Ballroom
Friday, June 22 \| 10:24AM - 10:24AM Departure *Session Chair.