Web Desc
Advances in Neurodegenerative Disease Research and Therapy
joint with New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet?
Organizer(s): Li Gan, Leonard Petrucelli and Morgan H. Sheng
Date: June 17 - 21, 2018
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Ionis Pharmaceuticals, Inc., Merck & Co., Inc., Nestlé Institute of Health Sciences, Roche and Takeda Pharmaceutical Company Limited
Summary of Meeting:
As the world population ages, neurodegenerative diseases are becoming the new epidemic in both developed and developing countries. Progress made in human genetics has revealed increasingly more disease-associated genes for Alzheimer’s disease (AD), Parkinson’s disease (PD), Frontotemoral dementia (FTD), amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. These discoveries have linked neurodegenerative diseases with several common key biological processes that have so far been under-studied, including RNA metabolism, protein trafficking and innate immune responses. By focusing on these emerging areas in neurodegenerative disease research, this conference seeks to challenge the current research paradigms and to inspire in-depth discussion and exploration. The program assembles leaders from various fields to facilitate interactions between groups using diverse approaches, by providing a platform to cross-fertilize ideas and to encourage new collaborations that could lead to novel mechanisms and therapeutic targets against neurodegenerative diseases.
Scholarship Deadline: February 15 2018
Discounted Abstract Deadline: February 15 2018
Abstract Deadline: March 15 2018
Discounted Registration Deadline: April 18 2018
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Ionis Pharmaceuticals, Inc.Merck & Co., Inc.Nestlé Institute of Health SciencesRocheTakeda Pharmaceutical Company Limited
We gratefully acknowledge additional support from these exhibitors at this conference:
AlzheimerDementia Consortium
We gratefully acknowledge additional support for this conference from:
Charles RiverTocris Bioscience
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Ionis Pharmaceuticals, Inc.

Sanofi US
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS106977-01
Funding for this conference was made possible (in part) by 1R13NS106977-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, June 17 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, June 17 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, June 18 | 7:30AM - 8:30AM
Breakfast
Room: Colorado Rockies Ballroom


Monday, June 18 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Quandary Peak

Speaker 1 of 2
* Li Gan, Weill Cornell Medicine, USA

Monday, June 18 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Quandary Peak

Speaker 2 of 2
Huda Y. Zoghbi, HHMI/Baylor College of Medicine, USA
Insights From Rare Disorders Shed Light on Common Neurodegenerative Diseases

Monday, June 18 | 9:30AM - 12:00PM
Genetics to Epigenetics in Neurodegenerative Diseases
Room: Quandary Peak

Speaker 1 of 7
* Leonard Petrucelli, Mayo Clinic Jacksonville, USA

Monday, June 18 | 9:30AM - 12:00PM
Genetics to Epigenetics in Neurodegenerative Diseases
Room: Quandary Peak

Speaker 2 of 7
John Hardy, University College London, Institute of Neurology, UK
Genomics and Pathways to Neurodegeneration

Monday, June 18 | 9:30AM - 12:00PM
Genetics to Epigenetics in Neurodegenerative Diseases
Room: Quandary Peak


Coffee Break

Monday, June 18 | 9:30AM - 12:00PM
Genetics to Epigenetics in Neurodegenerative Diseases
Room: Quandary Peak

Speaker 4 of 7
Catherine Marquer, Columbia University, USA
Short Talk: Excess Synaptojanin 1 Drives Age-Dependent Cognitive Deficits, a Unifying Mechanism for Individuals at High Risk of Alzheimer's Disease

Monday, June 18 | 9:30AM - 12:00PM
Genetics to Epigenetics in Neurodegenerative Diseases
Room: Quandary Peak

Speaker 5 of 7
Alison Goate, Icahn School of Medicine at Mount Sinai, USA
Genetic Studies Implicate Microglial Function in Alzheimer's Disease Risk

Monday, June 18 | 9:30AM - 12:00PM
Genetics to Epigenetics in Neurodegenerative Diseases
Room: Quandary Peak

Speaker 6 of 7
Li-Huei Tsai, Massachusetts Institute of Technology, USA
Transcriptomic Analysis at Single Cell Resolution in Neurodegeneration

Monday, June 18 | 9:30AM - 12:00PM
Genetics to Epigenetics in Neurodegenerative Diseases
Room: Quandary Peak

Speaker 7 of 7
John D. Fryer, Mayo Clinic, USA
Short Talk: Translational Profiling of Microglia Reveals a Shared apoE Pathway Common to Aging, Amyloid and Tau Pathology

Monday, June 18 | 9:30AM - 12:00PM
Immune Privilege, Blood-Brain Barrier and Microglia I
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 1 of 7
* Knut Biber, AbbVie Deutschland GmbH & Co. KG, Germany


Monday, June 18 | 9:30AM - 12:00PM
Immune Privilege, Blood-Brain Barrier and Microglia I
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 2 of 7
Josef Priller, Charité – Universitätsmedizin Berlin, Germany
From Bone Marrow to Brain: How Myeloid Cells Can Enter the CNS


Monday, June 18 | 9:30AM - 12:00PM
Immune Privilege, Blood-Brain Barrier and Microglia I
This session is from Neuroinflammation
Room: Grays/Longs Peak


Coffee Break


Monday, June 18 | 9:30AM - 12:00PM
Immune Privilege, Blood-Brain Barrier and Microglia I
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 4 of 7
Jonathan Kipnis, Washington University School of Medicine, USA
Lymphatics in the CNS and Their Role in Neurological Diseases


Monday, June 18 | 9:30AM - 12:00PM
Immune Privilege, Blood-Brain Barrier and Microglia I
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 5 of 7
Richard Daneman, University of California, San Diego, USA
Regulation of the Blood-Brain Barrier in Health and Disease


Monday, June 18 | 9:30AM - 12:00PM
Immune Privilege, Blood-Brain Barrier and Microglia I
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 6 of 7
Karen De Vlaminck, Vrije Universiteit Brussel, Belgium
Short Talk: The Fate and Dynamics of Microglia, Border Macrophages and Infiltrating Monocytes during the Onset and Resolution of Infectious Neuroinflammation


Monday, June 18 | 9:30AM - 12:00PM
Immune Privilege, Blood-Brain Barrier and Microglia I
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 7 of 7
Cayce Dorrier, University of California, San Diego, USA
Short Talk: The Role of the Fibrotic Scar in Repair following Neuroinflammation


Monday, June 18 | 12:00PM - 5:00PM
On Own for Lunch


Monday, June 18 | 12:00PM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Monday, June 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Monday, June 18 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, June 18 | 5:00PM - 7:00PM
Aging in Health and Disease
Room: Quandary Peak

Speaker 1 of 5
* Morgan H. Sheng, Broad Institute, USA

Monday, June 18 | 5:00PM - 7:00PM
Aging in Health and Disease
Room: Quandary Peak

Speaker 2 of 5
Andrew G. Dillin, University of California, Berkeley, USA
Aging in Protein, Homeostasis and Stress

Monday, June 18 | 5:00PM - 7:00PM
Aging in Health and Disease
Room: Quandary Peak

Speaker 3 of 5
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Contribution of Aging of Selective Autophagy to Neurodegeneration

Monday, June 18 | 5:00PM - 7:00PM
Aging in Health and Disease
Room: Quandary Peak

Speaker 4 of 5
Tony Wyss-Coray, Stanford University School of Medicine, USA
Dissecting the Role of Cerebrovascular Dysfunction in Brain Aging

Monday, June 18 | 5:00PM - 7:00PM
Aging in Health and Disease
Room: Quandary Peak

Speaker 5 of 5
Edward Giniger, NINDS, National Institutes of Health, USA
Short Talk: Separating the Roles of Autophagy, Immunity and Aging in Neurodegeneration

Monday, June 18 | 5:00PM - 7:00PM
Immune Privilege, Blood-Brain Barrier and Microglia II
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 1 of 5
* Bart J.L. Eggen, University Medical Center Groningen, Netherlands


Monday, June 18 | 5:00PM - 7:00PM
Immune Privilege, Blood-Brain Barrier and Microglia II
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 2 of 5
Marco Prinz, University of Freiburg, Germany
Myeloid Cell Activation and Kinetics in the Brain


Monday, June 18 | 5:00PM - 7:00PM
Immune Privilege, Blood-Brain Barrier and Microglia II
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 3 of 5
Doron Merkler, University of Geneva, Switzerland
Interaction between Neurons, Phagocytes and T Cells in Neuroinflammation


Monday, June 18 | 5:00PM - 7:00PM
Immune Privilege, Blood-Brain Barrier and Microglia II
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 4 of 5
Michal Schwartz, Weizmann Institute of Science, Israel
Fighting Alzheimer's Disease by Unleashing the Innate and Adaptive Immune Cells


Monday, June 18 | 5:00PM - 7:00PM
Immune Privilege, Blood-Brain Barrier and Microglia II
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 5 of 5
Zhen Xu, Shenzhen University, China
Short Talk: Repopulated Microglia Are Solely Derived from the Proliferation of Residual Microglia after Acute Depletion


Monday, June 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, June 18 | 7:30PM - 10:00PM
Poster Session 1
Room: Colorado Rockies Ballroom


Tuesday, June 19 | 7:30AM - 8:30AM
Breakfast
Room: Colorado Rockies Ballroom


Tuesday, June 19 | 8:30AM - 11:45AM
Innate Immunity
Room: Quandary Peak

Speaker 1 of 8
* David M. Holtzman, Washington University, USA

Tuesday, June 19 | 8:30AM - 11:45AM
Innate Immunity
Room: Quandary Peak

Speaker 2 of 8
Adriano M. Aguzzi, University Hospital of Zürich, Switzerland
Protein Aggregation and Pathways of Toxicity

Tuesday, June 19 | 8:30AM - 11:45AM
Innate Immunity
Room: Quandary Peak

Speaker 3 of 8
Christian Haass, Ludwig-Maximilians University Munich, Germany
Loss of TREM2 Function Increases Amyloid Seeding but Reduces Plaque-Associated ApoE

Tuesday, June 19 | 8:30AM - 11:45AM
Innate Immunity
Room: Quandary Peak

Speaker 4 of 8
Matthew A. Cooper, University of Queensland, Australia
Short Talk: Pharmacological Inhibition of the NLRP3 Inflammasome Prevents Synuclein Pathology and Dopaminergic
Degeneration in Parkinson's Disease


Tuesday, June 19 | 8:30AM - 11:45AM
Innate Immunity
Room: Quandary Peak


Coffee Break

Tuesday, June 19 | 8:30AM - 11:45AM
Innate Immunity
Room: Quandary Peak

Speaker 6 of 8
Christopher K. Glass, University of California, San Diego, USA
Genomic Approaches to Dissect Innate Immunity in Neurodegeneration

Tuesday, June 19 | 8:30AM - 11:45AM
Innate Immunity
Room: Quandary Peak

Speaker 7 of 8
Li Gan, Weill Cornell Medicine, USA
Microglia in Tau Proteostasis and Toxicity

Tuesday, June 19 | 8:30AM - 11:45AM
Innate Immunity
Room: Quandary Peak

Speaker 8 of 8
Andrew B. West, University of Alabama at Birmingham, USA
Short Talk: LRRK2 Mediates the Recruitment of Monocyte-Derived Macrophages to the Brain in Neurodegeneration

Tuesday, June 19 | 8:30AM - 11:45AM
Cross-Talk of Microglia with Other CNS Cells
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 1 of 8
* Katrin Kierdorf, Uniklinik Freiburg, Germany


Tuesday, June 19 | 8:30AM - 11:45AM
Cross-Talk of Microglia with Other CNS Cells
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 2 of 8
Mikael Simons, Technische Universität München, Germany
Cholesterol Metabolisms as Key Regulator of Phagocyte Function during Remyelination


Tuesday, June 19 | 8:30AM - 11:45AM
Cross-Talk of Microglia with Other CNS Cells
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 3 of 8
Francisco J. Quintana, Harvard Medical School, USA
Astrocytes and Microglia


Tuesday, June 19 | 8:30AM - 11:45AM
Cross-Talk of Microglia with Other CNS Cells
This session is from Neuroinflammation
Room: Grays/Longs Peak


Coffee Break


Tuesday, June 19 | 8:30AM - 11:45AM
Cross-Talk of Microglia with Other CNS Cells
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 5 of 8
Anna Victoria Molofsky, University of California, San Francisco, USA
Astrocyte-Microglial Communication in Developmental Synapse Remodeling


Tuesday, June 19 | 8:30AM - 11:45AM
Cross-Talk of Microglia with Other CNS Cells
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 6 of 8
Burkhard Becher, University of Zurich, Switzerland
T Cell Entry into the CNS: How Myelin Is Presented


Tuesday, June 19 | 8:30AM - 11:45AM
Cross-Talk of Microglia with Other CNS Cells
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 7 of 8
Courtney Malo, NIAID, National Institutes of Health, USA
Short Talk: MHC Class I Expression by Microglia Is Required for Generating a Complete Antigen-Specific CD8 T Cell Response
in the CNS


Tuesday, June 19 | 8:30AM - 11:45AM
Cross-Talk of Microglia with Other CNS Cells
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 8 of 8
Phi T. Nguyen, University of California, San Francisco, USA
Short Talk: The IL-33-IL1RL1 Signaling Axis Coordinates Remodeling and Integration of Adult-Born Neurons in the Hippocampus


Tuesday, June 19 | 11:45AM - 5:00PM
On Own for Lunch


Tuesday, June 19 | 11:45AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Tuesday, June 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Tuesday, June 19 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, June 19 | 5:00PM - 7:00PM
Neuronal and Network Dysfunction in Neurodegeneration
Room: Quandary Peak

Speaker 1 of 5
* Li-Huei Tsai, Massachusetts Institute of Technology, USA

Tuesday, June 19 | 5:00PM - 7:00PM
Neuronal and Network Dysfunction in Neurodegeneration
Room: Quandary Peak

Speaker 2 of 5
Huaxi Xu, Sanford Burnham Prebys Medical Discovery Institute, USA
A Novel Mechanism for Memory/Synaptic Dysfunction in Tauopathy

Tuesday, June 19 | 5:00PM - 7:00PM
Neuronal and Network Dysfunction in Neurodegeneration
Room: Quandary Peak

Speaker 3 of 5
Zayd M. Khaliq, NINDS, National Institutes of Health, USA
Dendritic Ca2+ Signaling in Substantia Nigra Dopamine Neuron Subpopulations

Tuesday, June 19 | 5:00PM - 7:00PM
Neuronal and Network Dysfunction in Neurodegeneration
Room: Quandary Peak

Speaker 4 of 5
Morgan H. Sheng, Broad Institute, USA
Mechanisms of Synapse Loss Revealed by Proteomic Analysis of Post-Synaptic Density in Tauopathy Mouse Model

Tuesday, June 19 | 5:00PM - 7:00PM
Neuronal and Network Dysfunction in Neurodegeneration
Room: Quandary Peak

Speaker 5 of 5
Keran Ma, University of California, San Francisco, USA
Short Talk: Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease

Tuesday, June 19 | 5:00PM - 7:00PM
Myeloid Cells and Neuroinflammation
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 1 of 5
* Erik H.W.G.M. Boddeke, University of Groningen, Netherlands


Tuesday, June 19 | 5:00PM - 7:00PM
Myeloid Cells and Neuroinflammation
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 2 of 5
Masaaki Murakami, Hokkaido University, Japan
Neural Stimulations Modulate the Formation of Immune Cell Gateways into the CNS


Tuesday, June 19 | 5:00PM - 7:00PM
Myeloid Cells and Neuroinflammation
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 3 of 5
Akihiko Yoshimura, Keio University, Japan
Regulation of Inflammation after Stroke by Macrophages and Regulatory T Cells


Tuesday, June 19 | 5:00PM - 7:00PM
Myeloid Cells and Neuroinflammation
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 4 of 5
Robyn S. Klein, Washington University School of Medicine, USA
Trm-Derived IFNg Causes Microglial-Mediated Spatial Learning Defects during Recovery from Differentially Neurotropic Flaviviruses


Tuesday, June 19 | 5:00PM - 7:00PM
Myeloid Cells and Neuroinflammation
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 5 of 5
Kevin G. Burfeind, Oregon Health & Science University, USA
Short Talk: Infiltrating Myeloid Cells in the Central Nervous System Mediate Cancer Cachexia


Tuesday, June 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, June 19 | 7:30PM - 10:00PM
Poster Session 2
Room: Colorado Rockies Ballroom


Wednesday, June 20 | 7:30AM - 8:30AM
Breakfast
Room: Colorado Rockies Ballroom


Wednesday, June 20 | 8:30AM - 11:45AM
Protein Trafficking and Degradation
Room: Quandary Peak

Speaker 1 of 9
* Tony Wyss-Coray, Stanford University School of Medicine, USA

Wednesday, June 20 | 8:30AM - 11:45AM
Protein Trafficking and Degradation
Room: Quandary Peak

Speaker 2 of 9
Baris Bingol, Genentech, Inc., USA
Lysosomal Degradation in Parkinson’s Disease

Wednesday, June 20 | 8:30AM - 11:45AM
Protein Trafficking and Degradation
Room: Quandary Peak

Speaker 3 of 9
Guojun Bu, Mayo Clinic, USA
Central and Peripheral ApoE4 in Cognition and Dementia

Wednesday, June 20 | 8:30AM - 11:45AM
Protein Trafficking and Degradation
Room: Quandary Peak

Speaker 4 of 9
Michael E. Ward, NINDS, National Institutes of Health, USA
Short Talk: Progranulin Mediates Endolysosomal Recruitment of the RNP-Associated Protein ANXA11

Wednesday, June 20 | 8:30AM - 11:45AM
Protein Trafficking and Degradation
Room: Quandary Peak


Coffee Break

Wednesday, June 20 | 8:30AM - 11:45AM
Protein Trafficking and Degradation
Room: Quandary Peak

Speaker 6 of 9
David M. Holtzman, Washington University, USA
Effects of ApoE in Tau-Mediated Neurodegeneration

Wednesday, June 20 | 8:30AM - 11:45AM
Protein Trafficking and Degradation
Room: Quandary Peak

Speaker 7 of 9
Jaehong Suh, Massachusetts General Hospital / Harvard Medical School, USA
Short Talk: Role of Ataxin-1 in BACE1 Expression and Axonal Targeting in the Cerebrum

Wednesday, June 20 | 8:30AM - 11:45AM
Protein Trafficking and Degradation
Room: Quandary Peak

Speaker 8 of 9
R. Jeremy Nichols, Parkinson's Institute, USA
Short Talk: SQSTM1/p62 Is a Novel Substrate of the Parkinson's Disease Kinase LRRK2 that Activates its Kinase Domain and Enhances Neuronal Toxicity

Wednesday, June 20 | 8:30AM - 11:45AM
Protein Trafficking and Degradation
Room: Quandary Peak

Speaker 9 of 9
Naruhiko Sahara, National Institute of Radiological Sciences, Japan
Short Talk: Neuroinflammatory Process during Pathogenesis of Tauopathy in rTg4510 Mice

Wednesday, June 20 | 8:30AM - 11:45AM
Imaging of the Healthy and Diseased CNS
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 1 of 8
* Sophia Bardehle, Merck, USA


Wednesday, June 20 | 8:30AM - 11:45AM
Imaging of the Healthy and Diseased CNS
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 2 of 8
Wenbiao Gan, Skirball Institute Program of Molecular Neurobiology, USA
The Role of Microglia in Learning-Dependent Synaptic Plasticity


Wednesday, June 20 | 8:30AM - 11:45AM
Imaging of the Healthy and Diseased CNS
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 3 of 8
Martin Kerschensteiner, Ludwig Maximilians University Munich, Germany
In vivo Analysis of Phagocyte Phenotypes and Effector Function


Wednesday, June 20 | 8:30AM - 11:45AM
Imaging of the Healthy and Diseased CNS
This session is from Neuroinflammation
Room: Grays/Longs Peak


Coffee Break


Wednesday, June 20 | 8:30AM - 11:45AM
Imaging of the Healthy and Diseased CNS
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 5 of 8
Melanie Meyer-Luehmann, University of Freiburg, Germany
Microglia Contribution to the Propagation of Abeta Pathology


Wednesday, June 20 | 8:30AM - 11:45AM
Imaging of the Healthy and Diseased CNS
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 6 of 8
Francesca Peri, European Molecular Biology Laboratory, Germany
Microglia and Neuronal Interactions


Wednesday, June 20 | 8:30AM - 11:45AM
Imaging of the Healthy and Diseased CNS
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 7 of 8
Anna Mechling, Roche Innovation Center Basel, Hoffmann-La Roche Ltd., Switzerland
Short Talk: Pivotal Role of Microglial TREM2 in Remyelination as Revealed by Multiparametric Magnetic Resonance Imaging in the Cuprizone Mouse Model


Wednesday, June 20 | 8:30AM - 11:45AM
Imaging of the Healthy and Diseased CNS
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 8 of 8
Vijayasree V. Giridharan, University of Texas Health Science Center, USA
Short Talk: Imaging of Microglial Activation in Experimental Bacterial Meningitis using PET/CT


Wednesday, June 20 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, June 20 | 11:45AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Wednesday, June 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Wednesday, June 20 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, June 20 | 5:00PM - 7:00PM
Disease Modeling
Room: Quandary Peak

Speaker 1 of 5
* Jeffrey D. Rothstein, Johns Hopkins University, USA

Wednesday, June 20 | 5:00PM - 7:00PM
Disease Modeling
Room: Quandary Peak

Speaker 2 of 5
Leslie M. Thompson, University of California, Irvine, USA
A Systems Biology Approach to Understanding ALS Pathogenesis in iPSC-Derived Motor Neurons

Wednesday, June 20 | 5:00PM - 7:00PM
Disease Modeling
Room: Quandary Peak

Speaker 3 of 5
Albert R. La Spada, Duke University, USA
Deconstructing Polyglutamine Neurodegeneration: From Pathways of Neuron Demise to Therapeutic Intervention

Wednesday, June 20 | 5:00PM - 7:00PM
Disease Modeling
Room: Quandary Peak

Speaker 4 of 5
Yadong Huang, Gladstone Institutes/UCSF, USA
Modeling and Drug Screening of AD Using Patients-Derived iPSCs

Wednesday, June 20 | 5:00PM - 7:00PM
Disease Modeling
Room: Quandary Peak

Speaker 5 of 5
Michael Lee, University of Minnesota, USA
Short Talk: Dissociation of Amyloid Dependent Cognitive Deficits and Neurodegeneration

Wednesday, June 20 | 5:00PM - 7:00PM
Myeloid Cells as Targets of Drug Discovery and Biomarkers
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 1 of 4
* Andrea Crotti, Astellas Pharma, USA


Wednesday, June 20 | 5:00PM - 7:00PM
Myeloid Cells as Targets of Drug Discovery and Biomarkers
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 2 of 4
Irene Knuesel, Roche Innovation Center Basel, Switzerland
Therapeutic Effects of Anti-Amyloid-Beta Immunotherapy on Myeloid Cell Transcriptome


Wednesday, June 20 | 5:00PM - 7:00PM
Myeloid Cells as Targets of Drug Discovery and Biomarkers
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 3 of 4
David R. Owen, Imperial College London, UK
Imaging Microglia in Humans


Wednesday, June 20 | 5:00PM - 7:00PM
Myeloid Cells as Targets of Drug Discovery and Biomarkers
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 4 of 4
Paul R. Ormel, University Medical Center Utrecht, Netherlands
Short Talk: Comparison of Three Human Microglia Models to Study Schizophrenia


Wednesday, June 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, June 20 | 7:30PM - 10:00PM
Poster Session 3
Room: Colorado Rockies Ballroom


Thursday, June 21 | 7:30AM - 8:30AM
Breakfast
Room: Colorado Rockies Ballroom


Thursday, June 21 | 8:30AM - 11:45AM
RNA Metabolisms and New Mechanisms of Toxicity
Room: Quandary Peak

Speaker 1 of 9
* Yadong Huang, Gladstone Institutes/UCSF, USA

Thursday, June 21 | 8:30AM - 11:45AM
RNA Metabolisms and New Mechanisms of Toxicity
Room: Quandary Peak

Speaker 2 of 9
Wolfdieter Springer, Mayo Clinic, USA
Short Talk: Relevance of PINK1-Parkin Mitophagy in Stress, Aging and Disease

Thursday, June 21 | 8:30AM - 11:45AM
RNA Metabolisms and New Mechanisms of Toxicity
Room: Quandary Peak

Speaker 3 of 9
Christopher D. Link, University of Colorado, USA
Short Talk: Knockdown of TDP-43 in Astrocytes Induces Immune Activation

Thursday, June 21 | 8:30AM - 11:45AM
RNA Metabolisms and New Mechanisms of Toxicity
Room: Quandary Peak

Speaker 4 of 9
Jeffrey D. Rothstein, Johns Hopkins University, USA
Nuclear Transport as an Unexpected Fundamental Defect in Familial and Sporadic Neurodegeneration

Thursday, June 21 | 8:30AM - 11:45AM
RNA Metabolisms and New Mechanisms of Toxicity
Room: Quandary Peak

Speaker 5 of 9
Zevik Melamed, University of California, San Diego, USA
Short Talk: RNA Processing Alteration and the Link to Neurodegeneration in ALS/FTD

Thursday, June 21 | 8:30AM - 11:45AM
RNA Metabolisms and New Mechanisms of Toxicity
Room: Quandary Peak


Coffee Break

Thursday, June 21 | 8:30AM - 11:45AM
RNA Metabolisms and New Mechanisms of Toxicity
Room: Quandary Peak

Speaker 7 of 9
Leonard Petrucelli, Mayo Clinic Jacksonville, USA
C9 Biology and Biomarkers

Thursday, June 21 | 8:30AM - 11:45AM
RNA Metabolisms and New Mechanisms of Toxicity
Room: Quandary Peak

Speaker 8 of 9
Bess Frost, Barshop Institute for Longevity and Aging Studies, USA
Jump Around, Jump Around: Transposable Element Activation in Tauopathy

Thursday, June 21 | 8:30AM - 11:45AM
RNA Metabolisms and New Mechanisms of Toxicity
Room: Quandary Peak

Speaker 9 of 9
Xin Qi, Case Western Reserve University, USA
Short Talk: ATAD3A Oligomerization Causes Neurodegeneration by Coupling Mitochondrial Fragmentation and Bioenergetics Defects

Thursday, June 21 | 8:30AM - 11:45AM
Myeloid Gene Regulation
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 1 of 8
* Inge R. Holtman, University of California, San Diego, USA


Thursday, June 21 | 8:30AM - 11:45AM
Myeloid Gene Regulation
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 2 of 8
Oleg Butovsky, Harvard Medical School, USA
Dual Faces of Dr. Jekyll Microglia: Degenerating Neurons Cannot 'Hyde'


Thursday, June 21 | 8:30AM - 11:45AM
Myeloid Gene Regulation
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 3 of 8
Ido Amit, Weizmann Institute, Israel
The Power of ONE: Immunology in the Age of Single Cell Genomics


Thursday, June 21 | 8:30AM - 11:45AM
Myeloid Gene Regulation
This session is from Neuroinflammation
Room: Grays/Longs Peak


Coffee Break


Thursday, June 21 | 8:30AM - 11:45AM
Myeloid Gene Regulation
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 5 of 8
Marco Colonna, Washington University School of Medicine, USA
TREM2, Microglia and Neurodegeneration


Thursday, June 21 | 8:30AM - 11:45AM
Myeloid Gene Regulation
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 6 of 8
Bahareh Ajami, Stanford University School of Medicine, USA
Single-Cell Mass Cytometry Reveals Molecular Signatures of Inflammation in Contrasting Models of Neuroinflammation versus Neurodegeneration


Thursday, June 21 | 8:30AM - 11:45AM
Myeloid Gene Regulation
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 7 of 8
Kendra Lechtenberg, Stanford University, USA
Short Talk: Profiling Microglia-Specific Transcriptional Changes after Ischemic Stroke


Thursday, June 21 | 8:30AM - 11:45AM
Myeloid Gene Regulation
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 8 of 8
Carole Lara Veiga Sousa, Luxembourg Institute of Health, Luxembourg
Short Talk: Molecular Profiling of Microglia in Steady State and Under Inflammatory Conditions at Single-Cell Level


Thursday, June 21 | 11:45AM - 5:00PM
On Own for Lunch


Thursday, June 21 | 2:30PM - 4:30PM
Workshop: Systems Approach and Functional Genomics
Room: Quandary Peak

Speaker 1 of 7
* Martin Kampmann, University of California, San Francisco, USA
Elucidating Cellular Mechanisms and Therapeutic Strategies for Neurodegenerative Diseases with CRISPRi and CRISPRa

Thursday, June 21 | 2:30PM - 4:30PM
Workshop: Systems Approach and Functional Genomics
Room: Quandary Peak

Speaker 2 of 7
Taisuke Kato, Niigata University, Japan
Phenotypic Suppression of DRPLA Model Mice using CRISPR / Cas9 System

Thursday, June 21 | 2:30PM - 4:30PM
Workshop: Systems Approach and Functional Genomics
Room: Quandary Peak

Speaker 3 of 7
Jiyoen Kim, Baylor College of Medicine, USA
Identifying Therapeutic Targets for Alzheimer's Disease: A Cross-Species Genetic Screen for Molecules that Lower Tau Levels

Thursday, June 21 | 2:30PM - 4:30PM
Workshop: Systems Approach and Functional Genomics
Room: Quandary Peak

Speaker 4 of 7
Alan E. Renton, Icahn School of Medicine at Mount Sinai, USA
Alzheimer's Disease Sequencing Project: Age Extremes x APOE Genotype Sampling for Genetic Discovery

Thursday, June 21 | 2:30PM - 4:30PM
Workshop: Systems Approach and Functional Genomics
Room: Quandary Peak

Speaker 5 of 7
Tara E. Tracy, University of California, San Francisco, USA
Spatiotemporal Mapping of the Tau Interactome in Human iPSC-Derived Neurons

Thursday, June 21 | 2:30PM - 4:30PM
Workshop: Systems Approach and Functional Genomics
Room: Quandary Peak

Speaker 6 of 7
Tal Nuriel, Columbia University Medical Center, USA
Utilizing Systems Biology Approaches to Elucidate the Effects of APOE4 Expression in an AD-Vulnerable Brain Region

Thursday, June 21 | 2:30PM - 4:30PM
Workshop: Systems Approach and Functional Genomics
Room: Quandary Peak

Speaker 7 of 7
Rakshita A. Charan, University of Pennsylvania, USA
Identification and Characterization of Frontotemporal Dementia Risk Factor TMEM106B Interacting Proteins

Thursday, June 21 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, June 21 | 5:00PM - 7:00PM
Biomarker and Therapeutics
Room: Quandary Peak

Speaker 1 of 6
* Li Gan, Weill Cornell Medicine, USA

Thursday, June 21 | 5:00PM - 7:00PM
Biomarker and Therapeutics
Room: Quandary Peak

Speaker 2 of 6
David V. Hansen, Genentech, Inc., USA
Short Talk: Assessing and Modulating Microglial Activation States in Alzheimer’s Disease Tissues and Models

Thursday, June 21 | 5:00PM - 7:00PM
Biomarker and Therapeutics
Room: Quandary Peak

Speaker 3 of 6
Xu Chen, Gladstone Institute of Neurological Disease, USA
Short Talk: Tau Secretion and Propagation is Regulated by p300/CBP via Autophagy-Lysosomal Pathway

Thursday, June 21 | 5:00PM - 7:00PM
Biomarker and Therapeutics
Room: Quandary Peak

Speaker 4 of 6
C. Frank Bennett, Ionis Pharmaceuticals, Inc., USA
Antisense Oligonucleotide-Based Therapies for Neurological Diseases



Thursday, June 21 | 5:00PM - 7:00PM
Biomarker and Therapeutics
Room: Quandary Peak

Speaker 5 of 6
Rita Balice-Gordon, Sanofi, Inc., USA
Translational Challenges in Neuroscience Drug Development

Thursday, June 21 | 5:00PM - 7:00PM
Biomarker and Therapeutics
Room: Quandary Peak

Speaker 6 of 6
Tracy Cole, Ionis Pharmaceuticals, Inc., USA
Short Talk: Human SNCA Antisense Oligonucleotides Reduce CNS and CSF Alpha-Synuclein Levels in a Non-Human Primate Model, Supporting their Use for Treatment of Synucleinopathies

Thursday, June 21 | 5:00PM - 6:45PM
Microglia and CNS Diseases
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 1 of 4
* Annett Halle, German Center for Neurodegenerative Diseases, Germany


Thursday, June 21 | 5:00PM - 6:45PM
Microglia and CNS Diseases
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 2 of 4
Shane Antony Liddelow, New York University Langone Medical Center, USA
What Do Reactive Astrocytes Do?


Thursday, June 21 | 5:00PM - 6:45PM
Microglia and CNS Diseases
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 3 of 4
Florent Ginhoux, Singapore Immunology Network, Singapore
Microglia Heterogeneity


Thursday, June 21 | 5:00PM - 6:45PM
Microglia and CNS Diseases
This session is from Neuroinflammation
Room: Grays/Longs Peak

Speaker 4 of 4
Philip L. De Jager, Columbia University Medical Center, USA
The Genetic and Population Architecture of Aged Human Microglia: Role in Accelerating Tau Pathology and Cognitive Decline


Thursday, June 21 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Neuroinflammation
Room: Grays/Longs Peak


Thursday, June 21 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Quandary Peak


Thursday, June 21 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, June 21 | 8:00PM - 11:00PM
Entertainment
Room: Colorado Rockies Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, June 21 | 8:00PM - 11:00PM
Cash Bar
Room: Colorado Rockies Ballroom


Friday, June 22 | 10:24AM - 10:24AM
Departure


*Session Chair.