Web Desc
DNA Replication and Genome Instability: From Mechanism to Disease
Organizer(s): Karlene A. Cimprich, Mark J. O'Connor and Johannes C. Walter
Date: January 13 - 17, 2019
Location: Snowbird Resort, Snowbird, UT, USA
Organized in collaboration with Cancer Research UK

This activity is supported by an educational grant from Celgene Corporation

Sponsored by Editas Medicine, EMD Serono Research and Development Institute, Inc. and TESARO, Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
This meeting will bring together scientists studying the most fundamental aspects of DNA replication and recombination, the organization and regulation of these processes at the cellular and molecular level, and their links to human disease. The aim is to disseminate the latest progress in this area; provide young scientists with the opportunity to present their work in a short talk or poster format; discuss the challenges and opportunities in developing basic research knowledge for the treatment of disease, and discuss the relevance of emerging work in other fields to genome instability and replication stress. Through talks and specialized workshops led by leaders in the field, the meeting will cover single-molecule to cellular and genome-level studies, providing an integrated view of the relationship between DNA replication, recombination and genome instability.
Scholarship Deadline: October 4 2018
Discounted Abstract Deadline: October 4 2018
Abstract Deadline: October 16 2018
Discounted Registration Deadline: November 13 2018
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Organized in collaboration with Cancer Research UKThis activity was supported by an educational grant from Celgene Corporation.Editas MedicineEMD Serono Research and Development Institute, Inc.TESARO, Inc.
We gratefully acknowledge additional support for this conference from:
AstraZeneca
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 13 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Sunday, January 13 | 6:00PM - 8:00PM
Welcome Mixer
Room: Ballroom Lobby
No registration fees are used to fund alcohol served at this function.

Monday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, January 14 | 8:00AM - 9:30AM
Welcome and Keynote Session
Room: Ballroom 2-3

Speaker 1 of 5
* Johannes C. Walter, Harvard Medical School, USA

Monday, January 14 | 8:00AM - 9:30AM
Welcome and Keynote Session
Room: Ballroom 2-3

Speaker 2 of 5
* Karlene A. Cimprich, Stanford University, USA

Monday, January 14 | 8:00AM - 9:30AM
Welcome and Keynote Session
Room: Ballroom 2-3

Speaker 3 of 5
David Cortez, Vanderbilt University School of Medicine, USA
Replication Fork Proteomes: How Many Proteins Are Needed?

Monday, January 14 | 8:00AM - 9:30AM
Welcome and Keynote Session
Room: Ballroom 2-3

Speaker 4 of 5
Eric C. Greene, Columbia University, USA
Single Molecule Analysis of Recombination

Monday, January 14 | 8:00AM - 9:30AM
Welcome and Keynote Session
Room: Ballroom 2-3


Coffee Break

Monday, January 14 | 9:50AM - 11:30AM
The Influence of Chromatin on Replication and Repair
Room: Ballroom 2-3

Speaker 1 of 6
* Karlene A. Cimprich, Stanford University, USA

Monday, January 14 | 9:50AM - 11:30AM
The Influence of Chromatin on Replication and Repair
Room: Ballroom 2-3

Speaker 2 of 6
* Johannes C. Walter, Harvard Medical School, USA

Monday, January 14 | 9:50AM - 11:30AM
The Influence of Chromatin on Replication and Repair
Room: Ballroom 2-3

Speaker 3 of 6
Iestyn Whitehouse, Memorial Sloan Kettering Cancer Center, USA
Coordination of Transcription and DNA Replication during Embryogenesis

Monday, January 14 | 9:50AM - 11:30AM
The Influence of Chromatin on Replication and Repair
Room: Ballroom 2-3

Speaker 4 of 6
Gaelle Legube, Center for Integrative Biology, France
Chromatin and Chromosome Dynamics during DNA Double-Strand Break Repair

Monday, January 14 | 9:50AM - 11:30AM
The Influence of Chromatin on Replication and Repair
Room: Ballroom 2-3

Speaker 5 of 6
Andrew N. Blackford, University of Oxford, UK
Short Talk: How Cells Respond to DNA Double-Strand Breaks in Mitosis

Monday, January 14 | 9:50AM - 11:30AM
The Influence of Chromatin on Replication and Repair
Room: Ballroom 2-3

Speaker 6 of 6
Philipp Oberdoerffer, NCI, National Institutes of Health, USA
Short Talk: Epigenetic Control of Genome Stability at the Inactive X Chromosome

Monday, January 14 | 11:30AM - 5:00PM
On Own for Lunch


Monday, January 14 | 11:30AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Monday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms of Replication
Room: Ballroom 2

Speaker 1 of 8
* Joseph Yeeles, MRC Laboratory of Molecular Biology, UK

Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms of Replication
Room: Ballroom 2

Speaker 2 of 8
Bik Kwoon Tye, Hong Kong University of Science and Technology, Hong Kong
Selectivity for Replication Origins by the Origin Recognition Complex


Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms of Replication
Room: Ballroom 2

Speaker 3 of 8
Nynke H. Dekker, Delft University of Technology, Netherlands
In vitro Single-Molecule Fluorescence Studies of Yeast Replication

Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms of Replication
Room: Ballroom 2

Speaker 4 of 8
Neha Puri, Johns Hopkins University School of Medicine, USA
Structural and Functional Coupling of ATP Turnover to Replicative Helicase Loading and Activation

Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms of Replication
Room: Ballroom 2

Speaker 5 of 8
Conrad A. Nieduszynski, University of Oxford, UK
Capturing the Dynamics of DNA Replication on Individual Ultra-Long Nanopore Sequencing Reads

Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms of Replication
Room: Ballroom 2

Speaker 6 of 8
Marko Lõoke, Massachusetts Institute of Technology, USA
Life without Mcm10: Identification and Characterization of Mcm2-7 Mutations that Fully Bypass Mcm10 Function

Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms of Replication
Room: Ballroom 2

Speaker 7 of 8
Nicholas E. Dixon, University of Wollongong, Australia
A Primase-Induced Conformational Switch Controls Polymerase Exchange in the Bacterial Replisome

Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms of Replication
Room: Ballroom 2

Speaker 8 of 8
Tatiana Moiseeva, University of Pittsburgh, USA
ATR/Chk1-Dependent Replication Initiation Control in Undamaged Cells

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Basic Mechanisms of Recombination
Room: Ballroom 3

Speaker 1 of 8
* Sharon B. Cantor, University of Massachusetts Medical School, USA

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Basic Mechanisms of Recombination
Room: Ballroom 3

Speaker 2 of 8
Wolf-Dietrich Heyer, University of California, Davis, USA
Mechanisms of Recombination: D-loop Reversal and Pathway Control

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Basic Mechanisms of Recombination
Room: Ballroom 3

Speaker 3 of 8
Akira Shinohara, Osaka University, Japan
Human RAD51 Paralog, SWSAP1, Promotes RAD51 Assembly by Regulating the Anti-Recombinase, FIGNL1 AAA+ATPase

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Basic Mechanisms of Recombination
Room: Ballroom 3

Speaker 4 of 8
Yizhou Joseph He, Dana-Farber Cancer Institute, USA
DYNLL1 Binds MRE11 to Limit DNA End Resection in BRCA1-Deficient Cells

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Basic Mechanisms of Recombination
Room: Ballroom 3

Speaker 5 of 8
Jordan Becker, University of Oxford, UK
The ASCIZ-DYNLL1 Axis Promotes 53BP1-Dependent Non-Homologous End-Joining and PARP Inhibitor Sensitivity

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Basic Mechanisms of Recombination
Room: Ballroom 3

Speaker 6 of 8
Yang Yu, Baylor College of Medicine, USA
Dna2 Nuclease Deficiency Results in Large and Complex DNA Insertions at Chromosomal Breaks

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Basic Mechanisms of Recombination
Room: Ballroom 3

Speaker 7 of 8
Dongyi Xu, Peking University, China
NAIF1-Constituted Nucleoskeleton Suppresses Chromosome Translocation and Tumorigenesis

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Basic Mechanisms of Recombination
Room: Ballroom 3

Speaker 8 of 8
Abigail Shea, CRUK Cambridge Institute, UK
A Co-Clinical Trial Investigating Targeted Agents in Breast Cancer Using Patient-Derived Tumour Xenograft Models

Monday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, January 14 | 5:00PM - 7:00PM
Mechanisms of DNA Replication
Room: Ballroom 2-3

Speaker 1 of 6
* Bik Kwoon Tye, Hong Kong University of Science and Technology, Hong Kong

Monday, January 14 | 5:00PM - 7:00PM
Mechanisms of DNA Replication
Room: Ballroom 2-3

Speaker 2 of 6
John F.X. Diffley, Francis Crick Institute, UK
Chromosome Replication: From Mechanism to Misregulation in Cancer

Monday, January 14 | 5:00PM - 7:00PM
Mechanisms of DNA Replication
Room: Ballroom 2-3

Speaker 3 of 6
Joseph Yeeles, MRC Laboratory of Molecular Biology, UK
Short Talk: Cryo-EM Structures of a 1.4 MDa Eukaryotic Replisome Progression Complex

Monday, January 14 | 5:00PM - 7:00PM
Mechanisms of DNA Replication
Room: Ballroom 2-3

Speaker 4 of 6
James M. Dewar, Vanderbilt University, USA
Short Talk: Multiple Roles for Topoisomerase IIa during Termination of Vertebrate DNA Replication

Monday, January 14 | 5:00PM - 7:00PM
Mechanisms of DNA Replication
Room: Ballroom 2-3

Speaker 5 of 6
Johannes C. Walter, Harvard Medical School, USA
TRAIP: Master Regulator of ICL Repair and CMG Unloading

Monday, January 14 | 5:00PM - 7:00PM
Mechanisms of DNA Replication
Room: Ballroom 2-3

Speaker 6 of 6
Kathleen Collins, University of California, Berkeley, USA
Telomerase Assembly and Action at Telomeres

Monday, January 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Monday, January 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby/Wasatch


Tuesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, January 15 | 8:00AM - 11:00AM
Mechanisms of Recombination and Repair
Room: Ballroom 2-3

Speaker 1 of 8
* Wolf-Dietrich Heyer, University of California, Davis, USA

Tuesday, January 15 | 8:00AM - 11:00AM
Mechanisms of Recombination and Repair
Room: Ballroom 2-3

Speaker 2 of 8
Stephen C. West, Francis Crick Institute, UK
MutSß Stimulates Holliday Junction Resolution by the SMX Tri-Nuclease

Tuesday, January 15 | 8:00AM - 11:00AM
Mechanisms of Recombination and Repair
Room: Ballroom 2-3

Speaker 3 of 8
Anna Malkova, University of Iowa, USA
In Search for the Link between Alternative Lengthening of Telomeres and the Mode of Telomere Erosion

Tuesday, January 15 | 8:00AM - 11:00AM
Mechanisms of Recombination and Repair
Room: Ballroom 2-3

Speaker 4 of 8
Aparna Gorthi, University of Texas Health at San Antonio, USA
Short Talk: Role of STAG2 in R-Loop Processing, Replication and Recombinational Repair

Tuesday, January 15 | 8:00AM - 11:00AM
Mechanisms of Recombination and Repair
Room: Ballroom 2-3


Coffee Break

Tuesday, January 15 | 8:00AM - 11:00AM
Mechanisms of Recombination and Repair
Room: Ballroom 2-3

Speaker 6 of 8
Joseph J. Loparo, Harvard Medical School, USA
How Non-homologous End-Joining Avoids Mistakes

Tuesday, January 15 | 8:00AM - 11:00AM
Mechanisms of Recombination and Repair
Room: Ballroom 2-3

Speaker 7 of 8
Agnel Sfeir, New York University School of Medicine, USA
Mechanism of Alternative End-Joining

Tuesday, January 15 | 8:00AM - 11:00AM
Mechanisms of Recombination and Repair
Room: Ballroom 2-3

Speaker 8 of 8
Chao Dong, University of Hong Kong, China
Short Talk: Fine-Tuning of Transcriptional Activities at DSBs by the DYRK1 Kinases

Tuesday, January 15 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, January 15 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Tuesday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Tuesday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, January 15 | 5:00PM - 7:00PM
Understanding and Exploiting Replication Stress
Room: Ballroom 2-3

Speaker 1 of 6
* David Cortez, Vanderbilt University School of Medicine, USA

Tuesday, January 15 | 5:00PM - 7:00PM
Understanding and Exploiting Replication Stress
Room: Ballroom 2-3

Speaker 2 of 6
Massimo Lopes, University of Zürich, Switzerland
Replication Fork Remodeling upon Cancer-Relevant Replication Stress

Tuesday, January 15 | 5:00PM - 7:00PM
Understanding and Exploiting Replication Stress
Room: Ballroom 2-3

Speaker 3 of 6
Sharon B. Cantor, University of Massachusetts Medical School, USA
Short Talk: Defining Mechanisms that Subvert the Replication Stress Response in Cancer

Tuesday, January 15 | 5:00PM - 7:00PM
Understanding and Exploiting Replication Stress
Room: Ballroom 2-3

Speaker 4 of 6
Mark J. O'Connor, AstraZeneca, UK
Reversing PARP Inhibitor Resistance by Targeting the Replication Stress Response

Tuesday, January 15 | 5:00PM - 7:00PM
Understanding and Exploiting Replication Stress
Room: Ballroom 2-3

Speaker 5 of 6
Giorgia Federico, University of Naples Federico II, Italy
Short Talk: NCOA4 Protein Couples Iron Availability to DNA Replication

Tuesday, January 15 | 5:00PM - 7:00PM
Understanding and Exploiting Replication Stress
Room: Ballroom 2-3

Speaker 6 of 6
Sarah A.E. Lambert, Institute Curie, France
Nuclear Spatial Organization of Replication Fork Processing in Fission Yeast

Tuesday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Tuesday, January 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby/Wasatch


Wednesday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, January 16 | 8:00AM - 11:00AM
Overcoming Replication Fork Obstacles
Room: Ballroom 2-3

Speaker 1 of 9
* Catherine H. Freudenreich, Tufts University, USA

Wednesday, January 16 | 8:00AM - 11:00AM
Overcoming Replication Fork Obstacles
Room: Ballroom 2-3

Speaker 2 of 9
Karim Labib, University of Dundee, UK
The Mechanism of CMG Helicase Ubiquitylation and Disassembly

Wednesday, January 16 | 8:00AM - 11:00AM
Overcoming Replication Fork Obstacles
Room: Ballroom 2-3

Speaker 3 of 9
Ralph Scully, Beth Israel Deaconess Medical Center, USA
Recombination and Repair at Stalled Mammalian Replication Forks

Wednesday, January 16 | 8:00AM - 11:00AM
Overcoming Replication Fork Obstacles
Room: Ballroom 2-3

Speaker 4 of 9
Boris Pfander, Max Planck Institute of Biochemistry, Germany
Short Talk: Cell Cycle Phase-Specific Recognition and Processing of DNA Over-Replication Forks

Wednesday, January 16 | 8:00AM - 11:00AM
Overcoming Replication Fork Obstacles
Room: Ballroom 2-3


Coffee Break

Wednesday, January 16 | 8:00AM - 11:00AM
Overcoming Replication Fork Obstacles
Room: Ballroom 2-3

Speaker 6 of 9
David Gallo, University of Toronto, Canada
Short Talk: Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates

Wednesday, January 16 | 8:00AM - 11:00AM
Overcoming Replication Fork Obstacles
Room: Ballroom 2-3

Speaker 7 of 9
Alessandro Vindigni, St. Louis University, USA
PrimPol-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA1-Deficient Tumors

Wednesday, January 16 | 8:00AM - 11:00AM
Overcoming Replication Fork Obstacles
Room: Ballroom 2-3

Speaker 8 of 9
Wojciech Niedzwiedz, Institute of Cancer Research, UK
Short Talk: EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2

Wednesday, January 16 | 8:00AM - 11:00AM
Overcoming Replication Fork Obstacles
Room: Ballroom 2-3

Speaker 9 of 9
Sriram Sridharan, Center for Cancer Research, USA
Short Talk: Landscape of Replication Stress Induced DNA Damage Sites

Wednesday, January 16 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, January 16 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Wednesday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop/Panel Discussion 3: Translating Basic Science to th
e Clinic
Room: Ballroom 2-3

Speaker 1 of 5
* Mark J. O'Connor, AstraZeneca, UK

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop/Panel Discussion 3: Translating Basic Science to th
e Clinic
Room: Ballroom 2-3

Speaker 2 of 5
* Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop/Panel Discussion 3: Translating Basic Science to th
e Clinic
Room: Ballroom 2-3

Speaker 3 of 5
Yves G. Pommier, NCI, National Institutes of Health, USA
Schlafen 11 (SLFN11), Replication Stress Executioner and its Potential Translation to the Clinic

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop/Panel Discussion 3: Translating Basic Science to th
e Clinic
Room: Ballroom 2-3

Speaker 4 of 5
Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
PARP Inhibitor Resistance and Acquired Vulnerability

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop/Panel Discussion 3: Translating Basic Science to th
e Clinic
Room: Ballroom 2-3

Speaker 5 of 5
Lauren A. Byers, MD Anderson Cancer Center, USA
Targeting DNA Damage Response (DDR) in Lung Cancer

Wednesday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, January 16 | 5:00PM - 7:00PM
RNA-Induced Genome Instability
Room: Ballroom 2-3

Speaker 1 of 6
* Gaelle Legube, Center for Integrative Biology, France

Wednesday, January 16 | 5:00PM - 7:00PM
RNA-Induced Genome Instability
Room: Ballroom 2-3

Speaker 2 of 6
Karlene A. Cimprich, Stanford University, USA
The Causes and Consequences of Replication Stress

Wednesday, January 16 | 5:00PM - 7:00PM
RNA-Induced Genome Instability
Room: Ballroom 2-3

Speaker 3 of 6
Andrew Jackson, University of Edinburgh, UK
The Fifth Element: Genomic Consequences of Embedded Ribonucleotides

Wednesday, January 16 | 5:00PM - 7:00PM
RNA-Induced Genome Instability
Room: Ballroom 2-3

Speaker 4 of 6
Peter C. Stirling, University of British Columbia, Canada
Short Talk: Nuclease-Independent Functions of Mre11-Rad50-Nbs1 Coordinate Cellular R-Loop Tolerance

Wednesday, January 16 | 5:00PM - 7:00PM
RNA-Induced Genome Instability
Room: Ballroom 2-3

Speaker 5 of 6
Jan-Gert Brüning, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Investigation of Replication-Transcription Collisions in vitro

Wednesday, January 16 | 5:00PM - 7:00PM
RNA-Induced Genome Instability
Room: Ballroom 2-3

Speaker 6 of 6
Houra Merrikh, Vanderbilt University, USA
The Impact of DNA Topology on Replication-Transcription Conflicts

Wednesday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Wednesday, January 16 | 7:30PM - 10:00PM
Poster Session 3
Room: Superior/Superior Lobby/Wasatch


Thursday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, January 17 | 8:00AM - 11:00AM
Genomic Drivers of Tumorigenesis and Drug Resistance
Room: Ballroom 2-3

Speaker 1 of 8
* Agnel Sfeir, New York University School of Medicine, USA

Thursday, January 17 | 8:00AM - 11:00AM
Genomic Drivers of Tumorigenesis and Drug Resistance
Room: Ballroom 2-3

Speaker 2 of 8
Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada
Mapping DNA Damage Networks with CRISPR-Based Genetic Screens

Thursday, January 17 | 8:00AM - 11:00AM
Genomic Drivers of Tumorigenesis and Drug Resistance
Room: Ballroom 2-3

Speaker 3 of 8
Christopher Lord, Institute of Cancer Research, UK
Using Genetics to Understand Synthetic Lethal Sensitivity and Resistance to DDR Inhibitors

Thursday, January 17 | 8:00AM - 11:00AM
Genomic Drivers of Tumorigenesis and Drug Resistance
Room: Ballroom 2-3

Speaker 4 of 8
Violeta Serra, Vall d'Hebron Institute of Oncology, Spain
Short Talk: Lack of RAD51 Nuclear Foci Formation Identifies Homologous Recombination Repair (HRR)-Deficient,PARPi-Sensitive Tumors Beyond Germline BRCA1/BRCA2 Mutation

Thursday, January 17 | 8:00AM - 11:00AM
Genomic Drivers of Tumorigenesis and Drug Resistance
Room: Ballroom 2-3


Coffee Break

Thursday, January 17 | 8:00AM - 11:00AM
Genomic Drivers of Tumorigenesis and Drug Resistance
Room: Ballroom 2-3

Speaker 6 of 8
Lee Zou, Harvard Medical School, USA
Roles of ATR in Countering APOBECs in Cancer Cells

Thursday, January 17 | 8:00AM - 11:00AM
Genomic Drivers of Tumorigenesis and Drug Resistance
Room: Ballroom 2-3

Speaker 7 of 8
Domenic Pilger, Sidney Sussex College, UK
Short Talk: ATM Orchestrates the DNA-Damage Response to Counter Toxic Non-Homologous End-Joining at Broken Replication Forks

Thursday, January 17 | 8:00AM - 11:00AM
Genomic Drivers of Tumorigenesis and Drug Resistance
Room: Ballroom 2-3

Speaker 8 of 8
Zachary K. Mirman, Rockefeller University, USA
53BP1/Rif1/Shieldin Counteract DSB Resection through CST/Pol Alpha-Dependent Fill-in

Thursday, January 17 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, January 17 | 2:30PM - 4:30PM
Workshop 4: Chromatin, Replication and Repair
Room: Ballroom 2

Speaker 1 of 7
* Evi Soutoglou, Institute of Genetics and Molecular and Cellular Biology, France
Double-Strand Break Relocation Correlates with Heterochromatic Repeat Clustering

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 4: Chromatin, Replication and Repair
Room: Ballroom 2

Speaker 2 of 7
Dominika T. Gruszka, Francis Crick Institute, UK
Replication-Coupled Parental Histone Dynamics Probed at Single Molecule Level

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 4: Chromatin, Replication and Repair
Room: Ballroom 2

Speaker 3 of 7
John K. Barrows, Medical University of South Carolina, USA
Establishing an in vitro System for Regulated Transcription and mRNA Processing

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 4: Chromatin, Replication and Repair
Room: Ballroom 2

Speaker 4 of 7
Caitlin Purman, Washington University in St. Louis, USA
Determining the Local Transcriptional Response to DNA Double-Strand Breaks in G1 Phase


Thursday, January 17 | 2:30PM - 4:30PM
Workshop 4: Chromatin, Replication and Repair
Room: Ballroom 2

Speaker 5 of 7
Nataliia Serbyn, University of Geneva, Switzerland
The Aspartic Protease Ddi1 Contributes to DPC Repair in Yeast

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 4: Chromatin, Replication and Repair
Room: Ballroom 2

Speaker 6 of 7
Diana E. Libuda, University of Oregon, USA
Temperature Increases Cause Transposon-Associated DNA Damage Specific to Spermatocytes and Not Oocytes

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 4: Chromatin, Replication and Repair
Room: Ballroom 2

Speaker 7 of 7
Mihaela Todorova Peycheva, IMP - Research Institute of Molecular Pathology, Austria
DNA Replication Is Critical for the Genesis of AID-Dependent Chromosomal Translocations in B Cells

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 5: Replication Stress and DNA Damage Signaling
Room: Ballroom 3

Speaker 1 of 7
* Niels Mailand, University of Copenhagen, Denmark
Profiling Cellular Signaling Responses to DNA-Protein Crosslinks

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 5: Replication Stress and DNA Damage Signaling
Room: Ballroom 3

Speaker 2 of 7
Kristijan Ramadan, University of Oxford, UK
SPRTN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards DNA Replication

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 5: Replication Stress and DNA Damage Signaling
Room: Ballroom 3

Speaker 3 of 7
Ya-Chu Chang, University of Minnesota, USA
Uncovering the Molecular Dynamics Upon Replication Fork Stalling using Proteomics

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 5: Replication Stress and DNA Damage Signaling
Room: Ballroom 3

Speaker 4 of 7
Claus Storgaard Sørensen, University of Copenhagen, Denmark
CtIP Variants Associated with Early-Onset Breast Cancer Compromise Replication Fork Stability

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 5: Replication Stress and DNA Damage Signaling
Room: Ballroom 3

Speaker 5 of 7
Sarem Hailemariam, Washington University, USA
Rif2 Inhibits the MRX-Dependent Activation of Tel1 Kinase

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 5: Replication Stress and DNA Damage Signaling
Room: Ballroom 3

Speaker 6 of 7
Robin van Schendel, Leiden University Medical Center, Netherlands
Okazaki Fragment Deposition Dictates Deletion Mutagenesis at Persistent Replication Fork Barriers

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 5: Replication Stress and DNA Damage Signaling
Room: Ballroom 3

Speaker 7 of 7
Catherine H. Freudenreich, Tufts University, USA
Collapsed Forks Caused by Expanded CAG Repeats Relocate to the Nuclear Pore in a Manner Dependent on SUMOylation of Repair Proteins

Thursday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, January 17 | 5:00PM - 6:45PM
Linking DNA Damage Response to the Immune Response
Room: Ballroom 2-3

Speaker 1 of 5
* Andrew Jackson, University of Edinburgh, UK

Thursday, January 17 | 5:00PM - 6:45PM
Linking DNA Damage Response to the Immune Response
Room: Ballroom 2-3

Speaker 2 of 5
Roger Greenberg, University of Pennsylvania, USA
DNA Damage Signaling to the Immune System

Thursday, January 17 | 5:00PM - 6:45PM
Linking DNA Damage Response to the Immune Response
Room: Ballroom 2-3

Speaker 3 of 5
Alberto Bardelli, University of Torino, Italy
Inactivation of DNA Repair to Improve Immune Surveillance

Thursday, January 17 | 5:00PM - 6:45PM
Linking DNA Damage Response to the Immune Response
Room: Ballroom 2-3

Speaker 4 of 5
Sophie Postel-Vinay, Gustave Roussy Cancer Campus, France
Combining DNA Damage Response (DDR) Inhibitors with Immunotherapy: The Next Step Change in Cancer Therapy?

Thursday, January 17 | 5:00PM - 6:45PM
Linking DNA Damage Response to the Immune Response
Room: Ballroom 2-3

Speaker 5 of 5
Timo Reislander, University of Oxford, UK
Short Talk: PARP Inhibitors Potentiate Cell-Intrinsic Immune Responses Triggered by BRCA2 Inactivation

Thursday, January 17 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Ballroom 2-3


Thursday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 1-2
No registration fees are used to fund alcohol served at this function.

Thursday, January 17 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 1-2
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 17 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 1-2


Friday, January 18 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.