Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
There are no records.

Web Desc
DNA Replication and Genome Instability: From Mechanism to Disease Organizer(s): Karlene A. Cimprich, Mark J. O'Connor and Johannes C. Walter Date: January 13 - 17, 2019 Location: Snowbird Resort, Snowbird, UT, USA Organized in collaboration with Cancer Research UK This activity is supported by an educational grant from Celgene Corporation Sponsored by Editas Medicine, EMD Serono Research and Development Institute, Inc. and TESARO, Inc. For important information on the coronavirus, please click here Summary of Meeting: This meeting will bring together scientists studying the most fundamental aspects of DNA replication and recombination, the organization and regulation of these processes at the cellular and molecular level, and their links to human disease. The aim is to disseminate the latest progress in this area; provide young scientists with the opportunity to present their work in a short talk or poster format; discuss the challenges and opportunities in developing basic research knowledge for the treatment of disease, and discuss the relevance of emerging work in other fields to genome instability and replication stress. Through talks and specialized workshops led by leaders in the field, the meeting will cover single-molecule to cellular and genome-level studies, providing an integrated view of the relationship between DNA replication, recombination and genome instability. Scholarship Deadline: October 4 2018 Discounted Abstract Deadline: October 4 2018 Abstract Deadline: October 16 2018 Discounted Registration Deadline: November 13 2018 Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested. Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

DNA Replication and Genome Instability: From Mechanism to Disease

Organizer(s): Karlene A. Cimprich, Mark J. O'Connor and Johannes C. Walter

Date: January 13 - 17, 2019
Location: Snowbird Resort, Snowbird, UT, USA

Organized in collaboration with Cancer Research UK

This activity is supported by an educational grant from Celgene Corporation

Sponsored by Editas Medicine, EMD Serono Research and Development Institute, Inc. and TESARO, Inc.

For important information on the coronavirus, please click here

Summary of Meeting:

This meeting will bring together scientists studying the most fundamental aspects of DNA replication and recombination, the organization and regulation of these processes at the cellular and molecular level, and their links to human disease. The aim is to disseminate the latest progress in this area; provide young scientists with the opportunity to present their work in a short talk or poster format; discuss the challenges and opportunities in developing basic research knowledge for the treatment of disease, and discuss the relevance of emerging work in other fields to genome instability and replication stress. Through talks and specialized workshops led by leaders in the field, the meeting will cover single-molecule to cellular and genome-level studies, providing an integrated view of the relationship between DNA replication, recombination and genome instability.

Scholarship Deadline: October 4 2018

Discounted Abstract Deadline: October 4 2018

Abstract Deadline: October 16 2018

Discounted Registration Deadline: November 13 2018

Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support for this conference from:

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, January 13 \| 4:00PM - 8:00PM Arrival and Registration Room: Ballroom Lobby
Sunday, January 13 \| 6:00PM - 8:00PM Welcome Mixer Room: Ballroom Lobby No registration fees are used to fund alcohol served at this function.
Monday, January 14 \| 7:00AM - 8:00AM Breakfast Room: Golden Cliff/Eagles
Monday, January 14 \| 8:00AM - 9:30AM Welcome and Keynote Session Room: Ballroom 2-3 Speaker 1 of 5 * Johannes C. Walter, Harvard Medical School, USA
Monday, January 14 \| 8:00AM - 9:30AM Welcome and Keynote Session Room: Ballroom 2-3 Speaker 2 of 5 * Karlene A. Cimprich, Stanford University, USA
Monday, January 14 \| 8:00AM - 9:30AM Welcome and Keynote Session Room: Ballroom 2-3 Speaker 3 of 5 David Cortez, Vanderbilt University School of Medicine, USA Replication Fork Proteomes: How Many Proteins Are Needed?
Monday, January 14 \| 8:00AM - 9:30AM Welcome and Keynote Session Room: Ballroom 2-3 Speaker 4 of 5 Eric C. Greene, Columbia University, USA Single Molecule Analysis of Recombination
Monday, January 14 \| 8:00AM - 9:30AM Welcome and Keynote Session Room: Ballroom 2-3 Coffee Break
Monday, January 14 \| 9:50AM - 11:30AM The Influence of Chromatin on Replication and Repair Room: Ballroom 2-3 Speaker 1 of 6 * Karlene A. Cimprich, Stanford University, USA
Monday, January 14 \| 9:50AM - 11:30AM The Influence of Chromatin on Replication and Repair Room: Ballroom 2-3 Speaker 2 of 6 * Johannes C. Walter, Harvard Medical School, USA
Monday, January 14 \| 9:50AM - 11:30AM The Influence of Chromatin on Replication and Repair Room: Ballroom 2-3 Speaker 3 of 6 Iestyn Whitehouse, Memorial Sloan Kettering Cancer Center, USA Coordination of Transcription and DNA Replication during Embryogenesis
Monday, January 14 \| 9:50AM - 11:30AM The Influence of Chromatin on Replication and Repair Room: Ballroom 2-3 Speaker 4 of 6 Gaelle Legube, Center for Integrative Biology, France Chromatin and Chromosome Dynamics during DNA Double-Strand Break Repair
Monday, January 14 \| 9:50AM - 11:30AM The Influence of Chromatin on Replication and Repair Room: Ballroom 2-3 Speaker 5 of 6 Andrew N. Blackford, University of Oxford, UK Short Talk: How Cells Respond to DNA Double-Strand Breaks in Mitosis
Monday, January 14 \| 9:50AM - 11:30AM The Influence of Chromatin on Replication and Repair Room: Ballroom 2-3 Speaker 6 of 6 Philipp Oberdoerffer, NCI, National Institutes of Health, USA Short Talk: Epigenetic Control of Genome Stability at the Inactive X Chromosome
Monday, January 14 \| 11:30AM - 5:00PM On Own for Lunch
Monday, January 14 \| 11:30AM - 1:00PM Poster Setup Room: Superior/Superior Lobby/Wasatch
Monday, January 14 \| 1:00PM - 10:00PM Poster Viewing Room: Superior/Superior Lobby/Wasatch
Monday, January 14 \| 2:30PM - 4:30PM Workshop 1: Basic Mechanisms of Replication Room: Ballroom 2 Speaker 1 of 8 * Joseph Yeeles, MRC Laboratory of Molecular Biology, UK
Monday, January 14 \| 2:30PM - 4:30PM Workshop 1: Basic Mechanisms of Replication Room: Ballroom 2 Speaker 2 of 8 Bik Kwoon Tye, Hong Kong University of Science and Technology, Hong Kong Selectivity for Replication Origins by the Origin Recognition Complex
Monday, January 14 \| 2:30PM - 4:30PM Workshop 1: Basic Mechanisms of Replication Room: Ballroom 2 Speaker 3 of 8 Nynke H. Dekker, Delft University of Technology, Netherlands In vitro Single-Molecule Fluorescence Studies of Yeast Replication
Monday, January 14 \| 2:30PM - 4:30PM Workshop 1: Basic Mechanisms of Replication Room: Ballroom 2 Speaker 4 of 8 Neha Puri, Johns Hopkins University School of Medicine, USA Structural and Functional Coupling of ATP Turnover to Replicative Helicase Loading and Activation
Monday, January 14 \| 2:30PM - 4:30PM Workshop 1: Basic Mechanisms of Replication Room: Ballroom 2 Speaker 5 of 8 Conrad A. Nieduszynski, University of Oxford, UK Capturing the Dynamics of DNA Replication on Individual Ultra-Long Nanopore Sequencing Reads
Monday, January 14 \| 2:30PM - 4:30PM Workshop 1: Basic Mechanisms of Replication Room: Ballroom 2 Speaker 6 of 8 Marko Lõoke, Massachusetts Institute of Technology, USA Life without Mcm10: Identification and Characterization of Mcm2-7 Mutations that Fully Bypass Mcm10 Function
Monday, January 14 \| 2:30PM - 4:30PM Workshop 1: Basic Mechanisms of Replication Room: Ballroom 2 Speaker 7 of 8 Nicholas E. Dixon, University of Wollongong, Australia A Primase-Induced Conformational Switch Controls Polymerase Exchange in the Bacterial Replisome
Monday, January 14 \| 2:30PM - 4:30PM Workshop 1: Basic Mechanisms of Replication Room: Ballroom 2 Speaker 8 of 8 Tatiana Moiseeva, University of Pittsburgh, USA ATR/Chk1-Dependent Replication Initiation Control in Undamaged Cells
Monday, January 14 \| 2:30PM - 4:30PM Workshop 2: Basic Mechanisms of Recombination Room: Ballroom 3 Speaker 1 of 8 * Sharon B. Cantor, University of Massachusetts Medical School, USA
Monday, January 14 \| 2:30PM - 4:30PM Workshop 2: Basic Mechanisms of Recombination Room: Ballroom 3 Speaker 2 of 8 Wolf-Dietrich Heyer, University of California, Davis, USA Mechanisms of Recombination: D-loop Reversal and Pathway Control
Monday, January 14 \| 2:30PM - 4:30PM Workshop 2: Basic Mechanisms of Recombination Room: Ballroom 3 Speaker 3 of 8 Akira Shinohara, Osaka University, Japan Human RAD51 Paralog, SWSAP1, Promotes RAD51 Assembly by Regulating the Anti-Recombinase, FIGNL1 AAA+ATPase
Monday, January 14 \| 2:30PM - 4:30PM Workshop 2: Basic Mechanisms of Recombination Room: Ballroom 3 Speaker 4 of 8 Yizhou Joseph He, Dana-Farber Cancer Institute, USA DYNLL1 Binds MRE11 to Limit DNA End Resection in BRCA1-Deficient Cells
Monday, January 14 \| 2:30PM - 4:30PM Workshop 2: Basic Mechanisms of Recombination Room: Ballroom 3 Speaker 5 of 8 Jordan Becker, University of Oxford, UK The ASCIZ-DYNLL1 Axis Promotes 53BP1-Dependent Non-Homologous End-Joining and PARP Inhibitor Sensitivity
Monday, January 14 \| 2:30PM - 4:30PM Workshop 2: Basic Mechanisms of Recombination Room: Ballroom 3 Speaker 6 of 8 Yang Yu, Baylor College of Medicine, USA Dna2 Nuclease Deficiency Results in Large and Complex DNA Insertions at Chromosomal Breaks
Monday, January 14 \| 2:30PM - 4:30PM Workshop 2: Basic Mechanisms of Recombination Room: Ballroom 3 Speaker 7 of 8 Dongyi Xu, Peking University, China NAIF1-Constituted Nucleoskeleton Suppresses Chromosome Translocation and Tumorigenesis
Monday, January 14 \| 2:30PM - 4:30PM Workshop 2: Basic Mechanisms of Recombination Room: Ballroom 3 Speaker 8 of 8 Abigail Shea, CRUK Cambridge Institute, UK A Co-Clinical Trial Investigating Targeted Agents in Breast Cancer Using Patient-Derived Tumour Xenograft Models
Monday, January 14 \| 4:30PM - 5:00PM Coffee Available Room: Ballroom Lobby
Monday, January 14 \| 5:00PM - 7:00PM Mechanisms of DNA Replication Room: Ballroom 2-3 Speaker 1 of 6 * Bik Kwoon Tye, Hong Kong University of Science and Technology, Hong Kong
Monday, January 14 \| 5:00PM - 7:00PM Mechanisms of DNA Replication Room: Ballroom 2-3 Speaker 2 of 6 John F.X. Diffley, Francis Crick Institute, UK Chromosome Replication: From Mechanism to Misregulation in Cancer
Monday, January 14 \| 5:00PM - 7:00PM Mechanisms of DNA Replication Room: Ballroom 2-3 Speaker 3 of 6 Joseph Yeeles, MRC Laboratory of Molecular Biology, UK Short Talk: Cryo-EM Structures of a 1.4 MDa Eukaryotic Replisome Progression Complex
Monday, January 14 \| 5:00PM - 7:00PM Mechanisms of DNA Replication Room: Ballroom 2-3 Speaker 4 of 6 James M. Dewar, Vanderbilt University, USA Short Talk: Multiple Roles for Topoisomerase IIa during Termination of Vertebrate DNA Replication
Monday, January 14 \| 5:00PM - 7:00PM Mechanisms of DNA Replication Room: Ballroom 2-3 Speaker 5 of 6 Johannes C. Walter, Harvard Medical School, USA TRAIP: Master Regulator of ICL Repair and CMG Unloading
Monday, January 14 \| 5:00PM - 7:00PM Mechanisms of DNA Replication Room: Ballroom 2-3 Speaker 6 of 6 Kathleen Collins, University of California, Berkeley, USA Telomerase Assembly and Action at Telomeres
Monday, January 14 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Superior/Superior Lobby/Wasatch No registration fees are used to fund alcohol served at this function.
Monday, January 14 \| 7:30PM - 10:00PM Poster Session 1 Room: Superior/Superior Lobby/Wasatch
Tuesday, January 15 \| 7:00AM - 8:00AM Breakfast Room: Golden Cliff/Eagles
Tuesday, January 15 \| 8:00AM - 11:00AM Mechanisms of Recombination and Repair Room: Ballroom 2-3 Speaker 1 of 8 * Wolf-Dietrich Heyer, University of California, Davis, USA
Tuesday, January 15 \| 8:00AM - 11:00AM Mechanisms of Recombination and Repair Room: Ballroom 2-3 Speaker 2 of 8 Stephen C. West, Francis Crick Institute, UK MutSß Stimulates Holliday Junction Resolution by the SMX Tri-Nuclease
Tuesday, January 15 \| 8:00AM - 11:00AM Mechanisms of Recombination and Repair Room: Ballroom 2-3 Speaker 3 of 8 Anna Malkova, University of Iowa, USA In Search for the Link between Alternative Lengthening of Telomeres and the Mode of Telomere Erosion
Tuesday, January 15 \| 8:00AM - 11:00AM Mechanisms of Recombination and Repair Room: Ballroom 2-3 Speaker 4 of 8 Aparna Gorthi, University of Texas Health at San Antonio, USA Short Talk: Role of STAG2 in R-Loop Processing, Replication and Recombinational Repair
Tuesday, January 15 \| 8:00AM - 11:00AM Mechanisms of Recombination and Repair Room: Ballroom 2-3 Coffee Break
Tuesday, January 15 \| 8:00AM - 11:00AM Mechanisms of Recombination and Repair Room: Ballroom 2-3 Speaker 6 of 8 Joseph J. Loparo, Harvard Medical School, USA How Non-homologous End-Joining Avoids Mistakes
Tuesday, January 15 \| 8:00AM - 11:00AM Mechanisms of Recombination and Repair Room: Ballroom 2-3 Speaker 7 of 8 Agnel Sfeir, New York University School of Medicine, USA Mechanism of Alternative End-Joining
Tuesday, January 15 \| 8:00AM - 11:00AM Mechanisms of Recombination and Repair Room: Ballroom 2-3 Speaker 8 of 8 Chao Dong, University of Hong Kong, China Short Talk: Fine-Tuning of Transcriptional Activities at DSBs by the DYRK1 Kinases
Tuesday, January 15 \| 11:00AM - 5:00PM On Own for Lunch
Tuesday, January 15 \| 11:00AM - 1:00PM Poster Setup Room: Superior/Superior Lobby/Wasatch
Tuesday, January 15 \| 1:00PM - 10:00PM Poster Viewing Room: Superior/Superior Lobby/Wasatch
Tuesday, January 15 \| 4:30PM - 5:00PM Coffee Available Room: Ballroom Lobby
Tuesday, January 15 \| 5:00PM - 7:00PM Understanding and Exploiting Replication Stress Room: Ballroom 2-3 Speaker 1 of 6 * David Cortez, Vanderbilt University School of Medicine, USA
Tuesday, January 15 \| 5:00PM - 7:00PM Understanding and Exploiting Replication Stress Room: Ballroom 2-3 Speaker 2 of 6 Massimo Lopes, University of Zürich, Switzerland Replication Fork Remodeling upon Cancer-Relevant Replication Stress
Tuesday, January 15 \| 5:00PM - 7:00PM Understanding and Exploiting Replication Stress Room: Ballroom 2-3 Speaker 3 of 6 Sharon B. Cantor, University of Massachusetts Medical School, USA Short Talk: Defining Mechanisms that Subvert the Replication Stress Response in Cancer
Tuesday, January 15 \| 5:00PM - 7:00PM Understanding and Exploiting Replication Stress Room: Ballroom 2-3 Speaker 4 of 6 Mark J. O'Connor, AstraZeneca, UK Reversing PARP Inhibitor Resistance by Targeting the Replication Stress Response
Tuesday, January 15 \| 5:00PM - 7:00PM Understanding and Exploiting Replication Stress Room: Ballroom 2-3 Speaker 5 of 6 Giorgia Federico, University of Naples Federico II, Italy Short Talk: NCOA4 Protein Couples Iron Availability to DNA Replication
Tuesday, January 15 \| 5:00PM - 7:00PM Understanding and Exploiting Replication Stress Room: Ballroom 2-3 Speaker 6 of 6 Sarah A.E. Lambert, Institute Curie, France Nuclear Spatial Organization of Replication Fork Processing in Fission Yeast
Tuesday, January 15 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Superior/Superior Lobby/Wasatch No registration fees are used to fund alcohol served at this function.
Tuesday, January 15 \| 7:30PM - 10:00PM Poster Session 2 Room: Superior/Superior Lobby/Wasatch
Wednesday, January 16 \| 7:00AM - 8:00AM Breakfast Room: Golden Cliff/Eagles
Wednesday, January 16 \| 8:00AM - 11:00AM Overcoming Replication Fork Obstacles Room: Ballroom 2-3 Speaker 1 of 9 * Catherine H. Freudenreich, Tufts University, USA
Wednesday, January 16 \| 8:00AM - 11:00AM Overcoming Replication Fork Obstacles Room: Ballroom 2-3 Speaker 2 of 9 Karim Labib, University of Dundee, UK The Mechanism of CMG Helicase Ubiquitylation and Disassembly
Wednesday, January 16 \| 8:00AM - 11:00AM Overcoming Replication Fork Obstacles Room: Ballroom 2-3 Speaker 3 of 9 Ralph Scully, Beth Israel Deaconess Medical Center, USA Recombination and Repair at Stalled Mammalian Replication Forks
Wednesday, January 16 \| 8:00AM - 11:00AM Overcoming Replication Fork Obstacles Room: Ballroom 2-3 Speaker 4 of 9 Boris Pfander, Max Planck Institute of Biochemistry, Germany Short Talk: Cell Cycle Phase-Specific Recognition and Processing of DNA Over-Replication Forks
Wednesday, January 16 \| 8:00AM - 11:00AM Overcoming Replication Fork Obstacles Room: Ballroom 2-3 Coffee Break
Wednesday, January 16 \| 8:00AM - 11:00AM Overcoming Replication Fork Obstacles Room: Ballroom 2-3 Speaker 6 of 9 David Gallo, University of Toronto, Canada Short Talk: Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates
Wednesday, January 16 \| 8:00AM - 11:00AM Overcoming Replication Fork Obstacles Room: Ballroom 2-3 Speaker 7 of 9 Alessandro Vindigni, St. Louis University, USA PrimPol-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA1-Deficient Tumors
Wednesday, January 16 \| 8:00AM - 11:00AM Overcoming Replication Fork Obstacles Room: Ballroom 2-3 Speaker 8 of 9 Wojciech Niedzwiedz, Institute of Cancer Research, UK Short Talk: EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2
Wednesday, January 16 \| 8:00AM - 11:00AM Overcoming Replication Fork Obstacles Room: Ballroom 2-3 Speaker 9 of 9 Sriram Sridharan, Center for Cancer Research, USA Short Talk: Landscape of Replication Stress Induced DNA Damage Sites
Wednesday, January 16 \| 11:00AM - 5:00PM On Own for Lunch
Wednesday, January 16 \| 11:00AM - 1:00PM Poster Setup Room: Superior/Superior Lobby/Wasatch
Wednesday, January 16 \| 1:00PM - 10:00PM Poster Viewing Room: Superior/Superior Lobby/Wasatch
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop/Panel Discussion 3: Translating Basic Science to th e Clinic Room: Ballroom 2-3 Speaker 1 of 5 * Mark J. O'Connor, AstraZeneca, UK
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop/Panel Discussion 3: Translating Basic Science to th e Clinic Room: Ballroom 2-3 Speaker 2 of 5 * Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop/Panel Discussion 3: Translating Basic Science to th e Clinic Room: Ballroom 2-3 Speaker 3 of 5 Yves G. Pommier, NCI, National Institutes of Health, USA Schlafen 11 (SLFN11), Replication Stress Executioner and its Potential Translation to the Clinic
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop/Panel Discussion 3: Translating Basic Science to th e Clinic Room: Ballroom 2-3 Speaker 4 of 5 Alan D. D'Andrea, Dana-Farber Cancer Institute, USA PARP Inhibitor Resistance and Acquired Vulnerability
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop/Panel Discussion 3: Translating Basic Science to th e Clinic Room: Ballroom 2-3 Speaker 5 of 5 Lauren A. Byers, MD Anderson Cancer Center, USA Targeting DNA Damage Response (DDR) in Lung Cancer
Wednesday, January 16 \| 4:30PM - 5:00PM Coffee Available Room: Ballroom Lobby
Wednesday, January 16 \| 5:00PM - 7:00PM RNA-Induced Genome Instability Room: Ballroom 2-3 Speaker 1 of 6 * Gaelle Legube, Center for Integrative Biology, France
Wednesday, January 16 \| 5:00PM - 7:00PM RNA-Induced Genome Instability Room: Ballroom 2-3 Speaker 2 of 6 Karlene A. Cimprich, Stanford University, USA The Causes and Consequences of Replication Stress
Wednesday, January 16 \| 5:00PM - 7:00PM RNA-Induced Genome Instability Room: Ballroom 2-3 Speaker 3 of 6 Andrew Jackson, University of Edinburgh, UK The Fifth Element: Genomic Consequences of Embedded Ribonucleotides
Wednesday, January 16 \| 5:00PM - 7:00PM RNA-Induced Genome Instability Room: Ballroom 2-3 Speaker 4 of 6 Peter C. Stirling, University of British Columbia, Canada Short Talk: Nuclease-Independent Functions of Mre11-Rad50-Nbs1 Coordinate Cellular R-Loop Tolerance
Wednesday, January 16 \| 5:00PM - 7:00PM RNA-Induced Genome Instability Room: Ballroom 2-3 Speaker 5 of 6 Jan-Gert Brüning, Memorial Sloan Kettering Cancer Center, USA Short Talk: Investigation of Replication-Transcription Collisions in vitro
Wednesday, January 16 \| 5:00PM - 7:00PM RNA-Induced Genome Instability Room: Ballroom 2-3 Speaker 6 of 6 Houra Merrikh, Vanderbilt University, USA The Impact of DNA Topology on Replication-Transcription Conflicts
Wednesday, January 16 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Superior/Superior Lobby/Wasatch No registration fees are used to fund alcohol served at this function.
Wednesday, January 16 \| 7:30PM - 10:00PM Poster Session 3 Room: Superior/Superior Lobby/Wasatch
Thursday, January 17 \| 7:00AM - 8:00AM Breakfast Room: Golden Cliff/Eagles
Thursday, January 17 \| 8:00AM - 11:00AM Genomic Drivers of Tumorigenesis and Drug Resistance Room: Ballroom 2-3 Speaker 1 of 8 * Agnel Sfeir, New York University School of Medicine, USA
Thursday, January 17 \| 8:00AM - 11:00AM Genomic Drivers of Tumorigenesis and Drug Resistance Room: Ballroom 2-3 Speaker 2 of 8 Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada Mapping DNA Damage Networks with CRISPR-Based Genetic Screens
Thursday, January 17 \| 8:00AM - 11:00AM Genomic Drivers of Tumorigenesis and Drug Resistance Room: Ballroom 2-3 Speaker 3 of 8 Christopher Lord, Institute of Cancer Research, UK Using Genetics to Understand Synthetic Lethal Sensitivity and Resistance to DDR Inhibitors
Thursday, January 17 \| 8:00AM - 11:00AM Genomic Drivers of Tumorigenesis and Drug Resistance Room: Ballroom 2-3 Speaker 4 of 8 Violeta Serra, Vall d'Hebron Institute of Oncology, Spain Short Talk: Lack of RAD51 Nuclear Foci Formation Identifies Homologous Recombination Repair (HRR)-Deficient,PARPi-Sensitive Tumors Beyond Germline BRCA1/BRCA2 Mutation
Thursday, January 17 \| 8:00AM - 11:00AM Genomic Drivers of Tumorigenesis and Drug Resistance Room: Ballroom 2-3 Coffee Break
Thursday, January 17 \| 8:00AM - 11:00AM Genomic Drivers of Tumorigenesis and Drug Resistance Room: Ballroom 2-3 Speaker 6 of 8 Lee Zou, Harvard Medical School, USA Roles of ATR in Countering APOBECs in Cancer Cells
Thursday, January 17 \| 8:00AM - 11:00AM Genomic Drivers of Tumorigenesis and Drug Resistance Room: Ballroom 2-3 Speaker 7 of 8 Domenic Pilger, Sidney Sussex College, UK Short Talk: ATM Orchestrates the DNA-Damage Response to Counter Toxic Non-Homologous End-Joining at Broken Replication Forks
Thursday, January 17 \| 8:00AM - 11:00AM Genomic Drivers of Tumorigenesis and Drug Resistance Room: Ballroom 2-3 Speaker 8 of 8 Zachary K. Mirman, Rockefeller University, USA 53BP1/Rif1/Shieldin Counteract DSB Resection through CST/Pol Alpha-Dependent Fill-in
Thursday, January 17 \| 11:00AM - 5:00PM On Own for Lunch
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 4: Chromatin, Replication and Repair Room: Ballroom 2 Speaker 1 of 7 * Evi Soutoglou, Institute of Genetics and Molecular and Cellular Biology, France Double-Strand Break Relocation Correlates with Heterochromatic Repeat Clustering
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 4: Chromatin, Replication and Repair Room: Ballroom 2 Speaker 2 of 7 Dominika T. Gruszka, Francis Crick Institute, UK Replication-Coupled Parental Histone Dynamics Probed at Single Molecule Level
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 4: Chromatin, Replication and Repair Room: Ballroom 2 Speaker 3 of 7 John K. Barrows, Medical University of South Carolina, USA Establishing an in vitro System for Regulated Transcription and mRNA Processing
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 4: Chromatin, Replication and Repair Room: Ballroom 2 Speaker 4 of 7 Caitlin Purman, Washington University in St. Louis, USA Determining the Local Transcriptional Response to DNA Double-Strand Breaks in G1 Phase
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 4: Chromatin, Replication and Repair Room: Ballroom 2 Speaker 5 of 7 Nataliia Serbyn, University of Geneva, Switzerland The Aspartic Protease Ddi1 Contributes to DPC Repair in Yeast
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 4: Chromatin, Replication and Repair Room: Ballroom 2 Speaker 6 of 7 Diana E. Libuda, University of Oregon, USA Temperature Increases Cause Transposon-Associated DNA Damage Specific to Spermatocytes and Not Oocytes
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 4: Chromatin, Replication and Repair Room: Ballroom 2 Speaker 7 of 7 Mihaela Todorova Peycheva, IMP - Research Institute of Molecular Pathology, Austria DNA Replication Is Critical for the Genesis of AID-Dependent Chromosomal Translocations in B Cells
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 5: Replication Stress and DNA Damage Signaling Room: Ballroom 3 Speaker 1 of 7 * Niels Mailand, University of Copenhagen, Denmark Profiling Cellular Signaling Responses to DNA-Protein Crosslinks
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 5: Replication Stress and DNA Damage Signaling Room: Ballroom 3 Speaker 2 of 7 Kristijan Ramadan, University of Oxford, UK SPRTN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards DNA Replication
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 5: Replication Stress and DNA Damage Signaling Room: Ballroom 3 Speaker 3 of 7 Ya-Chu Chang, University of Minnesota, USA Uncovering the Molecular Dynamics Upon Replication Fork Stalling using Proteomics
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 5: Replication Stress and DNA Damage Signaling Room: Ballroom 3 Speaker 4 of 7 Claus Storgaard Sørensen, University of Copenhagen, Denmark CtIP Variants Associated with Early-Onset Breast Cancer Compromise Replication Fork Stability
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 5: Replication Stress and DNA Damage Signaling Room: Ballroom 3 Speaker 5 of 7 Sarem Hailemariam, Washington University, USA Rif2 Inhibits the MRX-Dependent Activation of Tel1 Kinase
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 5: Replication Stress and DNA Damage Signaling Room: Ballroom 3 Speaker 6 of 7 Robin van Schendel, Leiden University Medical Center, Netherlands Okazaki Fragment Deposition Dictates Deletion Mutagenesis at Persistent Replication Fork Barriers
Thursday, January 17 \| 2:30PM - 4:30PM Workshop 5: Replication Stress and DNA Damage Signaling Room: Ballroom 3 Speaker 7 of 7 Catherine H. Freudenreich, Tufts University, USA Collapsed Forks Caused by Expanded CAG Repeats Relocate to the Nuclear Pore in a Manner Dependent on SUMOylation of Repair Proteins
Thursday, January 17 \| 4:30PM - 5:00PM Coffee Available Room: Ballroom Lobby
Thursday, January 17 \| 5:00PM - 6:45PM Linking DNA Damage Response to the Immune Response Room: Ballroom 2-3 Speaker 1 of 5 * Andrew Jackson, University of Edinburgh, UK
Thursday, January 17 \| 5:00PM - 6:45PM Linking DNA Damage Response to the Immune Response Room: Ballroom 2-3 Speaker 2 of 5 Roger Greenberg, University of Pennsylvania, USA DNA Damage Signaling to the Immune System
Thursday, January 17 \| 5:00PM - 6:45PM Linking DNA Damage Response to the Immune Response Room: Ballroom 2-3 Speaker 3 of 5 Alberto Bardelli, University of Torino, Italy Inactivation of DNA Repair to Improve Immune Surveillance
Thursday, January 17 \| 5:00PM - 6:45PM Linking DNA Damage Response to the Immune Response Room: Ballroom 2-3 Speaker 4 of 5 Sophie Postel-Vinay, Gustave Roussy Cancer Campus, France Combining DNA Damage Response (DDR) Inhibitors with Immunotherapy: The Next Step Change in Cancer Therapy?
Thursday, January 17 \| 5:00PM - 6:45PM Linking DNA Damage Response to the Immune Response Room: Ballroom 2-3 Speaker 5 of 5 Timo Reislander, University of Oxford, UK Short Talk: PARP Inhibitors Potentiate Cell-Intrinsic Immune Responses Triggered by BRCA2 Inactivation
Thursday, January 17 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Ballroom 2-3
Thursday, January 17 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Ballroom 1-2 No registration fees are used to fund alcohol served at this function.
Thursday, January 17 \| 8:00PM - 11:00PM Entertainment Room: Ballroom 1-2 Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, January 17 \| 8:00PM - 11:00PM Cash Bar Room: Ballroom 1-2
Friday, January 18 \| 10:24AM - 10:24AM Departure *Session Chair †Invited, not yet responded.