Web Desc
Skin Health and Disease: Immune, Epithelial and Microbiome Crosstalk
Organizer(s): Michel Gilliet, Emma Guttman, Anthony Oro and Manolis Pasparakis
Date: April 08 - 11, 2019
Location: Herrenhausen Palace, Hannover, Germany
Organized in collaboration with Volkswagen Foundation
Summary of Meeting:
The skin is the largest human organ and the primary interface between the body and the environment. It provides the first line of defense against invading pathogens and trauma via its physical barrier properties but also via active defense mechanisms orchestrated by a coordinated interplay between epithelial and immune cells. Recently, the skin microbiota has emerged as an important third player that critically influences skin homeostasis and inflammation by interacting with epithelial and immune cells. This conference highlights these reciprocal interactions and describes their impact on skin physiology and pathophysiology. A central focus is to discuss how the composition of the skin microbiota regulates homeostasis and determines susceptibility to inflammatory, allergic and neoplastic diseases of the skin and other epithelial tissues. Emerging concepts regarding the mechanisms influencing the epithelial-immune-microbiota crosstalk and opportunities for therapeutic interventions will be discussed. The conference provides a unique setting for in-depth, cross-disciplinary discussions between basic skin scientists and biologists studying immune responses in other barrier organs, as well as dermatologists, cancer biologists, immunologists and many researchers from disparate fields who normally do not have opportunities to meet. This conference will also foster interaction with potential industry partners, who increasingly see the skin as a major focus for gaining insights into immune mechanisms and for development of targeted therapies for patients with chronic inflammatory diseases, allergic diseases and cancer. Finally, the conference will promote the scientific and professional development of all attendees, with a special emphasis on trainees and early-career scientists.
Global Health Travel Award Deadline: November 13 2018
Scholarship Deadline: January 10 2019
Discounted Abstract Deadline: December 12 2018
Abstract Deadline: January 10 2019
Discounted Registration Deadline: February 7 2019
We gratefully acknowledge additional support for this conference from:
Zymo Research Corporation
Keystone Symposia thanks the Volkswagen Foundation for hosting this conference:
in Cooperation with Volkswagen Foundation
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Grant No. 1R13AR075401-01
Funding for this conference was made possible (in part) by 1R13AR075401-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, April 08 | 4:00PM - 8:00PM
Arrival and Registration
Room: Grand Mussmann Hotel, Tivoli Room


Monday, April 08 | 6:00PM - 8:00PM
Welcome Mixer
Room: Central-Hotel Kaiserhof
No registration fees are used to fund alcohol served at this function.

Tuesday, April 09 | 8:30AM - 9:45AM
Welcome and Keynote Address
Room: Auditorium
Welcome Remarks by Michel Gilliet, Emma Guttman, Anthony Oro and Manolis Pasparakis.

Welcome from local academic institution, Thomas Werfel, Hannover Medical School

Welcome Remarks by Henrike Hartmann, VolkswagenStiftung
Speaker 1 of 2
* Michel Gilliet, University Hospital of Lausanne, Switzerland

Tuesday, April 09 | 8:30AM - 9:45AM
Welcome and Keynote Address
Room: Auditorium
Welcome Remarks by Michel Gilliet, Emma Guttman, Anthony Oro and Manolis Pasparakis.

Welcome from local academic institution, Thomas Werfel, Hannover Medical School

Welcome Remarks by Henrike Hartmann, VolkswagenStiftung
Speaker 2 of 2
Richard L. Gallo, University of California, San Diego, USA
Skin Microbiome in Health and Disease – The Holobiome Perspective

Tuesday, April 09 | 9:45AM - 12:15PM
Epithelial-Microbiome Interactions in the Skin
Room: Auditorium

Speaker 1 of 6
* Julie A. Segre, National Institutes of Health, USA
Human Skin Microbiome: Trans-Kingdom, Host-Immune Interactions

Tuesday, April 09 | 9:45AM - 12:15PM
Epithelial-Microbiome Interactions in the Skin
Room: Auditorium


Coffee Break

Tuesday, April 09 | 9:45AM - 12:15PM
Epithelial-Microbiome Interactions in the Skin
Room: Auditorium

Speaker 3 of 6
Yasmine Belkaid, NIAID, National Institutes of Health, USA
The Skin Microbiota in the Control of Skin Immunity

Tuesday, April 09 | 9:45AM - 12:15PM
Epithelial-Microbiome Interactions in the Skin
Room: Auditorium

Speaker 4 of 6
Elizabeth A. Grice, University of Pennsylvania, USA
Microbial Roles in Skin Barrier Function and Repair

Tuesday, April 09 | 9:45AM - 12:15PM
Epithelial-Microbiome Interactions in the Skin
Room: Auditorium

Speaker 5 of 6
Jan Claesen, Cleveland Clinic, USA
Short Talk: Cutibacterium Acnes Antibiotic Production Shapes Niche Competition in the Human Skin Microbiome at the Level
of Individual Follicles


Tuesday, April 09 | 9:45AM - 12:15PM
Epithelial-Microbiome Interactions in the Skin
Room: Auditorium

Speaker 6 of 6
Mercedes Gomez de Aguero, University of Würzburg, Germany
Short Talk: Neonatal Skin Barrier Is Shaped by Embryonic Exposure to Maternal Microbiota

Tuesday, April 09 | 12:15PM - 1:00PM
Lunch
Room: Ballroom


Tuesday, April 09 | 12:15PM - 12:30PM
Poster Setup
Room: Ballroom


Tuesday, April 09 | 1:00PM - 8:30PM
Poster Viewing
Room: Ballroom


Tuesday, April 09 | 1:00PM - 3:00PM
Workshop 1
Room: Auditorium

Speaker 1 of 9
* Angela M. Christiano, Columbia University, USA

Tuesday, April 09 | 1:00PM - 3:00PM
Workshop 1
Room: Auditorium

Speaker 2 of 9
Jacob S. Baker, Massachusetts Institute of Technology, USA
Transmission and Evolution of Cutibacterium Acnes during Human Development

Tuesday, April 09 | 1:00PM - 3:00PM
Workshop 1
Room: Auditorium

Speaker 3 of 9
Roland Jourdain, L'Oreal, France
Malassezia restricta-Mediated Lipoperoxidation: A New Player in Dandruff Origin

Tuesday, April 09 | 1:00PM - 3:00PM
Workshop 1
Room: Auditorium

Speaker 4 of 9
Emmi Wachsmuth, University Hospital Cologne, Germany
Cell Autonomous Functions of Insulin/IGF-1 Signaling in Skin Barrier Function and Diabetes-Induced Skin Disease

Tuesday, April 09 | 1:00PM - 3:00PM
Workshop 1
Room: Auditorium

Speaker 5 of 9
Snehlata Kumari, CECAD Research Center, University of Cologne, Germany
Immunomodulatory Role of Epithelial IKK/NF-?B Signaling in Necroptosis -Mediated Skin Inflammation

Tuesday, April 09 | 1:00PM - 3:00PM
Workshop 1
Room: Auditorium

Speaker 6 of 9
Stephen Murtough, Queen Mary University of London, UK
iRhom2-mediated Immune Dysregulation: Impact on the Skin and Oesophagus

Tuesday, April 09 | 1:00PM - 3:00PM
Workshop 1
Room: Auditorium

Speaker 7 of 9
Edgar A.E. Serfling, Institute of Pathology, Germany
The Osmosensitive Transcription Factor NFAT5 Controls the Integrity of Skin

Tuesday, April 09 | 1:00PM - 3:00PM
Workshop 1
Room: Auditorium

Speaker 8 of 9
Zsolt Dajnoki, University of Debrecen, Hungary
Prominent Permeability Barrier Alterations in Rosacea Skin

Tuesday, April 09 | 1:00PM - 3:00PM
Workshop 1
Room: Auditorium

Speaker 9 of 9
Gudrun F. Debes, Thomas Jefferson University, USA
IgM Plasma Cells Reside in Healthy Skin and Accumulate with Chronic Inflammation

Tuesday, April 09 | 3:00PM - 3:30PM
Coffee Available
Room: Foyer


Tuesday, April 09 | 3:30PM - 5:30PM
Epithelial-Immune Interactions in the Skin
Room: Auditorium

Speaker 1 of 5
* Amy S. Paller, Northwestern University, USA
Genetic Barrier Disorders with Inflammation and Microbiome Abnormalities

Tuesday, April 09 | 3:30PM - 5:30PM
Epithelial-Immune Interactions in the Skin
Room: Auditorium

Speaker 2 of 5
Angela M. Christiano, Columbia University, USA
Immune Control of Hair Follicles

Tuesday, April 09 | 3:30PM - 5:30PM
Epithelial-Immune Interactions in the Skin
Room: Auditorium

Speaker 3 of 5
Sabine Eming, University of Cologne, Germany
Metabolic Control of Skin Inflammation

Tuesday, April 09 | 3:30PM - 5:30PM
Epithelial-Immune Interactions in the Skin
Room: Auditorium

Speaker 4 of 5
Anand Kumar Andiappan, Singapore Immunology Network, Singapore
Short Talk: Genome-Wide Gene Expression Identifies Strong Proinflammatory Signatures Associated with Skin-Relevant FLG
Mutants with Potential as Non-Invasive Biomarkers for Skin Disease


Tuesday, April 09 | 3:30PM - 5:30PM
Epithelial-Immune Interactions in the Skin
Room: Auditorium

Speaker 5 of 5
Tom Hayday, King's College London, UK
Short Talk: EGFR Regulates Cell Autonomous Pro-Inflammatory Signaling in Keratinocytes

Tuesday, April 09 | 5:30PM - 7:00PM
Social Hour with Lite Bites
Room: Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, April 09 | 6:00PM - 8:30PM
Poster Session 1
Room: Ballroom


Wednesday, April 10 | 8:30AM - 11:30AM
Microbiota-Immune Interactions in Skin and other Epithelial
Surfaces

Room: Auditorium

Speaker 1 of 7
* Michel Gilliet, University Hospital of Lausanne, Switzerland
Role of Microbiota in Innate Immune Responses of the Skin

Wednesday, April 10 | 8:30AM - 11:30AM
Microbiota-Immune Interactions in Skin and other Epithelial
Surfaces

Room: Auditorium

Speaker 2 of 7
Daniel H. Kaplan, University of Pittsburgh, USA
Cutaneous Nociceptors Trigger Protective Innate Type-17 Anticipatory Immunity

Wednesday, April 10 | 8:30AM - 11:30AM
Microbiota-Immune Interactions in Skin and other Epithelial
Surfaces

Room: Auditorium


Coffee Break

Wednesday, April 10 | 8:30AM - 11:30AM
Microbiota-Immune Interactions in Skin and other Epithelial
Surfaces

Room: Auditorium

Speaker 4 of 7
* Manolis Pasparakis, University of Cologne, Germany
Microbiota-Immune Interactions in Intestinal Inflammation

Wednesday, April 10 | 8:30AM - 11:30AM
Microbiota-Immune Interactions in Skin and other Epithelial
Surfaces

Room: Auditorium

Speaker 5 of 7
John Common, Skin Research Institute of Singapore, Singapore
Skin Microbiome Signatures in Atopic Dermatitis Are Linked to Host Immunity and Microbial Virulence

Wednesday, April 10 | 8:30AM - 11:30AM
Microbiota-Immune Interactions in Skin and other Epithelial
Surfaces

Room: Auditorium

Speaker 6 of 7
Yiyin Erin Chen, Stanford University, USA
Short Talk: Understanding Commensal-Host Communication through Genetic Engineering of Staphylococcus epidermidis

Wednesday, April 10 | 8:30AM - 11:30AM
Microbiota-Immune Interactions in Skin and other Epithelial
Surfaces

Room: Auditorium

Speaker 7 of 7
Annika Krueger, University of Queensland, Diamantina Institute, Australia
Short Talk: Secreted Bacterial Proteins from Staphylococcus aureus as Local Regulators of Epithelial Inflammation in Photo-Damaged Skin

Wednesday, April 10 | 11:30AM - 1:00PM
Lunch
Room: Ballroom


Wednesday, April 10 | 11:30AM - 12:30PM
Poster Setup
Room: Ballroom


Wednesday, April 10 | 1:00PM - 8:30PM
Poster Viewing
Room: Ballroom


Wednesday, April 10 | 1:00PM - 3:00PM
Workshop 2
Room: Auditorium

Speaker 1 of 9
* Yasmine Belkaid, NIAID, National Institutes of Health, USA

Wednesday, April 10 | 1:00PM - 3:00PM
Workshop 2
Room: Auditorium

Speaker 2 of 9
Karmella Naidoo, Malaghan Institute of Medical Research, New Zealand
Mucosal-Associated Invariant T (MAIT) Cells as A Novel Therapeutic Target against Atopic Dermatitis

Wednesday, April 10 | 1:00PM - 3:00PM
Workshop 2
Room: Auditorium

Speaker 3 of 9
Lennart M. Rösner, Dpt of Dermatology and Allergy, Hannover Medical School, Germany
T Cell Receptor Sequencing Underlines the Pivotal Role of Skin-Homing T Cells in Atopic Dermatitis

Wednesday, April 10 | 1:00PM - 3:00PM
Workshop 2
Room: Auditorium

Speaker 4 of 9
Travis M. Whitfill, Azitra Inc., USA
Engineering the Microbiome to Treat Netherton Syndrome, a Rare Skin Disease

Wednesday, April 10 | 1:00PM - 3:00PM
Workshop 2
Room: Auditorium

Speaker 5 of 9
David Isaac Weiss, University of California, Los Angeles, USA
IL-1ß Stimulates Rapid Release of the Antimicrobial Protein IL-26 from Th17 Cells

Wednesday, April 10 | 1:00PM - 3:00PM
Workshop 2
Room: Auditorium

Speaker 6 of 9
Anissa Fries, University Hospital of Lausanne, Switzerland
Pathogenic Role of Interleukin (IL)-26-Producing Th17 Cells in the Acute Forms of Psoriasis

Wednesday, April 10 | 1:00PM - 3:00PM
Workshop 2
Room: Auditorium

Speaker 7 of 9
Lucie Loyal, BCRT/Charite, Germany
Circulating CD8+ Helper-Type T Cell Memory Subsets Represent CD4+ Helper-Alike Cells with a Skin-Resident Memory T Cell Signature

Wednesday, April 10 | 1:00PM - 3:00PM
Workshop 2
Room: Auditorium

Speaker 8 of 9
Franziska Herster, University of Tübingen, Germany
Platelet-Neutrophil Aggregates Promote Skin Pathology in Psoriasis

Wednesday, April 10 | 1:00PM - 3:00PM
Workshop 2
Room: Auditorium

Speaker 9 of 9
Anne Müller, University of Tuebingen, Germany
I?B? Is a Key Mediator of IL-36 Signaling in Psoriasis

Wednesday, April 10 | 3:00PM - 3:30PM
Coffee Available
Room: Foyer


Wednesday, April 10 | 3:30PM - 5:30PM
Skin Dysbiosis and Allergic Inflammation
Room: Auditorium

Speaker 1 of 5
* Emma Guttman, Mount Sinai Hospital, USA
Atopic Dermatitis: A Th2 and Th22 Driven Disease & Therapeutic Implications

Wednesday, April 10 | 3:30PM - 5:30PM
Skin Dysbiosis and Allergic Inflammation
Room: Auditorium

Speaker 2 of 5
Heidi H. Kong, National Institutes of Health, USA
Skin Microbiota and Development of Atopic Dermatitis

Wednesday, April 10 | 3:30PM - 5:30PM
Skin Dysbiosis and Allergic Inflammation
Room: Auditorium

Speaker 3 of 5
Brian Kim, Washington University School of Medicine, USA
The Skin Neuro-Immune Axis, Dysbiosis and Itch

Wednesday, April 10 | 3:30PM - 5:30PM
Skin Dysbiosis and Allergic Inflammation
Room: Auditorium

Speaker 4 of 5
Bernhard Homey, University of Duesseldorf, Germany
Short Talk: Microbe-Host Interplay in Atopic Dermatitis and Psoriasis

Wednesday, April 10 | 3:30PM - 5:30PM
Skin Dysbiosis and Allergic Inflammation
Room: Auditorium

Speaker 5 of 5
Jennifer Wing-Ki Yau, Chinese University of Hong Kong, Hong Kong
Short Talk: Taxonomic and Functional Profiling of Skin Metagenomes Associated with Childhood Atopic Dermatitis

Wednesday, April 10 | 5:30PM - 7:00PM
Social Hour with Lite Bites
Room: Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, April 10 | 6:00PM - 8:30PM
Poster Session 2
Room: Ballroom


Thursday, April 11 | 8:30AM - 11:45AM
Epithelial-Microbiota-Immune Interactions in Tumorigenesis a
nd Systemic Diseases

Room: Auditorium

Speaker 1 of 8
* Anthony Oro, Stanford University, USA
Microenvironment Signaling in Skin Tumor Development and Resistance

Thursday, April 11 | 8:30AM - 11:45AM
Epithelial-Microbiota-Immune Interactions in Tumorigenesis a
nd Systemic Diseases

Room: Auditorium

Speaker 2 of 8
Gian Paolo Dotto, University of Lausanne, Switzerland
Genetic and Epigenetic Determinants of Cancer-Associated Fibroblast Activation in Field Cancerization

Thursday, April 11 | 8:30AM - 11:45AM
Epithelial-Microbiota-Immune Interactions in Tumorigenesis a
nd Systemic Diseases

Room: Auditorium


Coffee Break

Thursday, April 11 | 8:30AM - 11:45AM
Epithelial-Microbiota-Immune Interactions in Tumorigenesis a
nd Systemic Diseases

Room: Auditorium

Speaker 4 of 8
Tiffany C. Scharschmidt, University of California, San Francisco, USA
Early-Life Immune-Microbe Crosstalk in Skin

Thursday, April 11 | 8:30AM - 11:45AM
Epithelial-Microbiota-Immune Interactions in Tumorigenesis a
nd Systemic Diseases

Room: Auditorium

Speaker 5 of 8
Sandra Iden, University of Cologne, Germany
Epidermal Polarity Networks in Non-Cell Autonomous Control of Skin Immunity and Melanoma

Thursday, April 11 | 8:30AM - 11:45AM
Epithelial-Microbiota-Immune Interactions in Tumorigenesis a
nd Systemic Diseases

Room: Auditorium

Speaker 6 of 8
Esther Hoste, VIB-Ugent, Belgium
Short Talk: Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils to NETosis

Thursday, April 11 | 8:30AM - 11:45AM
Epithelial-Microbiota-Immune Interactions in Tumorigenesis a
nd Systemic Diseases

Room: Auditorium

Speaker 7 of 8
Giel Tanghe, Ghent University, Belgium
Short Talk: RIPK4 Maintains Epidermal Homeostasis and Prevents Skin Cancer

Thursday, April 11 | 8:30AM - 11:45AM
Epithelial-Microbiota-Immune Interactions in Tumorigenesis a
nd Systemic Diseases

Room: Auditorium

Speaker 8 of 8
Niki Ubags, University of Lausanne, Switzerland
Short Talk: The Skin Microbiome Drives Immune Maturation and Exacerbation of Both Skin and Airway Inflammation

Thursday, April 11 | 11:45AM - 1:00PM
Lunch
Room: Ballroom


Thursday, April 11 | 1:00PM - 3:15PM
Emerging Therapeutic Concepts
Room: Auditorium

Speaker 1 of 6
Kari Nadeau, Stanford University, USA
Novel Therapies and Immune Regulation of Food Allergies

Thursday, April 11 | 1:00PM - 3:15PM
Emerging Therapeutic Concepts
Room: Auditorium

Speaker 2 of 6
* James G. Krueger, Rockefeller University, USA
Therapeutic Targeting Epithelial/Immune Pathways in Inflammatory Skin Diseases

Thursday, April 11 | 1:00PM - 3:15PM
Emerging Therapeutic Concepts
Room: Auditorium

Speaker 3 of 6
George D. Yancopoulos, Regeneron Pharmaceuticals, Inc., USA
Regeneron's Efforts in Atopic and Allergic Conditions: From Dupilumab...to 'BiSpecs' that Kill Long-Lived IgE Plasma Cells

Thursday, April 11 | 1:00PM - 3:15PM
Emerging Therapeutic Concepts
Room: Auditorium

Speaker 4 of 6
Bernhard Paetzold, S-Biomedic, Belgium
Short Talk: Direct Modulation of the Skin Microbiome as Potential Therapy for Acne Vulgaris: A Pilot Study

Thursday, April 11 | 1:00PM - 3:15PM
Emerging Therapeutic Concepts
Room: Auditorium

Speaker 5 of 6
Miao-Tzu Huang, National Taiwan University Hospital, Taiwan
Short Talk: Short-Chain Fatty Acids Ameliorate Allergic Inflammation via Induction of Immune-Regulatory Microbiome and Metabolic Pathways

Thursday, April 11 | 1:00PM - 3:15PM
Emerging Therapeutic Concepts
Room: Auditorium

Speaker 6 of 6
Aisleen Diaz, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Changes in Skin Biomarkers Following Crisaborole Treatment Correlate With Clinical Improvement in Atopic Dermatitis

Thursday, April 11 | 3:15PM - 3:30PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Auditorium


Thursday, April 11 | 3:30PM - 5:00PM
Closing Reception and Lite Bites
Room: Ballroom
No registration fees are used to fund alcohol served at this function.

Friday, April 12 | 10:24AM - 10:24AM
Departure


*Session Chair.