Web Desc
Biomolecular Condensates: Phase-Separated Organizers of Cellular Biochemistry
Organizer(s): Michael K. Rosen and Anthony Hyman
Date: April 10 - 13, 2019
Location: Snowbird Resort, Snowbird, UT, USA
Supported by the Directors' Fund
Summary of Meeting:
Biomolecular condensates are cellular compartments that concentrate proteins and nucleic acids without an encapsulating membrane. They act in processes across the biological spectrum, from RNA metabolism to signaling and gene regulation. Macromolecular phase separation, akin to the separation of oil from water, has emerged over the past several years as a key organizer both of condensates, and of micron-scale cell organization in general. This conference brings together for the first time at Keystone Symposia scientists studying biomolecular condensates and macromolecular phase separation from varied perspectives and across scales of length and time. Theory, biophysics, biochemistry, cell biology and developmental biology will be joined together to address central questions in the field—how is molecular specificity in condensates achieved, how are the material properties and spatial structure of condensates controlled, how do composition and physical properties lead to emergent functions, how does aberrant formation of condensates lead to diseases such as neurodegeneration and cancer? By bringing together leading scientists from diverse areas impacted by phase separation, we hope to clarify the current state of knowledge in this exciting new field and identify important future directions.
Scholarship Deadline: December 13 2018
Discounted Abstract Deadline: December 13 2018
Abstract Deadline: January 10 2019
Discounted Registration Deadline: February 12 2019
We gratefully acknowledge additional support for this conference from:
Dewpoint Therapeutics
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, April 10 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Wednesday, April 10 | 6:00PM - 8:00PM
Welcome Mixer
Room: Ballroom Lobby
No registration fees are used to fund alcohol served at this function.

Thursday, April 11 | 7:30AM - 8:30AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, April 11 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Ballroom 2-3

Speaker 1 of 3
* Michael K. Rosen, University of Texas Southwestern Medical Center, USA

Thursday, April 11 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Ballroom 2-3

Speaker 2 of 3
* Anthony Hyman, Max Planck Institute of Molecular Cell Biology & Genetics, Germany

Thursday, April 11 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Ballroom 2-3

Speaker 3 of 3
Clifford P. Brangwynne, Princeton University, USA
Moving through Intracellular Phase Space

Thursday, April 11 | 9:30AM - 12:00PM
Physical Mechanisms of Macromolecular Phase Separation and R
egulation

Room: Ballroom 2-3
To introduce the physical mechanisms of macromolecular phase separation, as well as its regulation.
Speaker 1 of 7
* Julia Mahamid, European Molecular Biology Laboratory, Germany

Thursday, April 11 | 9:30AM - 12:00PM
Physical Mechanisms of Macromolecular Phase Separation and R
egulation

Room: Ballroom 2-3
To introduce the physical mechanisms of macromolecular phase separation, as well as its regulation.
Speaker 2 of 7
Frank Jülicher, Max-Planck-Institute for the Physics of Complex Systems, Germany
The Physics of Protein Condensates

Thursday, April 11 | 9:30AM - 12:00PM
Physical Mechanisms of Macromolecular Phase Separation and R
egulation

Room: Ballroom 2-3
To introduce the physical mechanisms of macromolecular phase separation, as well as its regulation.
Speaker 3 of 7
Nicolas L. Fawzi, Brown University, USA
Short Talk: Structure/Function of LC Domain Phase Separation in RNA-Binding Proteins FUS and TDP-43

Thursday, April 11 | 9:30AM - 12:00PM
Physical Mechanisms of Macromolecular Phase Separation and R
egulation

Room: Ballroom 2-3
To introduce the physical mechanisms of macromolecular phase separation, as well as its regulation.

Coffee Break

Thursday, April 11 | 9:30AM - 12:00PM
Physical Mechanisms of Macromolecular Phase Separation and R
egulation

Room: Ballroom 2-3
To introduce the physical mechanisms of macromolecular phase separation, as well as its regulation.
Speaker 5 of 7
Robert Tycko, NIDDK, National Institutes of Health, USA
Structure of Low-Complexity Protein Assemblies

Thursday, April 11 | 9:30AM - 12:00PM
Physical Mechanisms of Macromolecular Phase Separation and R
egulation

Room: Ballroom 2-3
To introduce the physical mechanisms of macromolecular phase separation, as well as its regulation.
Speaker 6 of 7
Diana M. Mitrea, St. Jude Children's Research Hospital, USA
Short Talk: Dynamic Rearrangements within NPM1-Mediated Scaffolds: Implications for Ribosome Biogenesis Regulation

Thursday, April 11 | 9:30AM - 12:00PM
Physical Mechanisms of Macromolecular Phase Separation and R
egulation

Room: Ballroom 2-3
To introduce the physical mechanisms of macromolecular phase separation, as well as its regulation.
Speaker 7 of 7
Rohit V. Pappu, Washington University in St. Louis, USA
Multiscale Structure of Biomolecular Condensates

Thursday, April 11 | 12:00PM - 5:00PM
On Own for Lunch


Thursday, April 11 | 12:00PM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Thursday, April 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Thursday, April 11 | 2:30PM - 4:30PM
Workshop
Room: Balroom 2-3

Speaker 1 of 9
* Michael K. Rosen, University of Texas Southwestern Medical Center, USA

Thursday, April 11 | 2:30PM - 4:30PM
Workshop
Room: Balroom 2-3

Speaker 2 of 9
Krishna Shrinivas, Massachussets Institute of Technology, USA
Enhancer Features that Mediate Formation of Localized Transcription Condensates

Thursday, April 11 | 2:30PM - 4:30PM
Workshop
Room: Balroom 2-3

Speaker 3 of 9
Liang Wang, Tsinghua University, China
Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism

Thursday, April 11 | 2:30PM - 4:30PM
Workshop
Room: Balroom 2-3

Speaker 4 of 9
Matthias Altmeyer, University of Zurich, Switzerland
Phase Separation of 53BP1 Ascertains Liquid-Like Behaviour of DNA Repair Compartments

Thursday, April 11 | 2:30PM - 4:30PM
Workshop
Room: Balroom 2-3

Speaker 5 of 9
Christoph Zechner, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Noise Buffering by Phase Separated Compartments

Thursday, April 11 | 2:30PM - 4:30PM
Workshop
Room: Balroom 2-3

Speaker 6 of 9
Huaiying Zhang, Carnegie Mellon University, USA
Phase Transition Drives Telomere Clustering

Thursday, April 11 | 2:30PM - 4:30PM
Workshop
Room: Balroom 2-3

Speaker 7 of 9
Miriam Linsenmeier, ETH Zurich, Switzerland
A Droplet-Based Microfluidic Platform to Investigate the Kinetics of Synthetic Membraneless Organelles in Cell-Like Volumes

Thursday, April 11 | 2:30PM - 4:30PM
Workshop
Room: Balroom 2-3

Speaker 8 of 9
Meta Heidenreich, Weizmann Institute of Science, Israel
A Synthetic Minimal System Connects Atomic Structure to Mesoscale Phenotypes of Protein Phase Separation

Thursday, April 11 | 2:30PM - 4:30PM
Workshop
Room: Balroom 2-3

Speaker 9 of 9
Cong Yu, Southern University of Science and Technology, China
Biomolecular Condensates in Focal Adhesion

Thursday, April 11 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, April 11 | 5:00PM - 7:00PM
Structure and Substructure of Biomolecular Condensates
Room: Ballroom 2-3
To introduce the idea that many condensates are not homogeneous, and often contain subcompartments.
Speaker 1 of 6
* Rohit V. Pappu, Washington University in St. Louis, USA

Thursday, April 11 | 5:00PM - 7:00PM
Structure and Substructure of Biomolecular Condensates
Room: Ballroom 2-3
To introduce the idea that many condensates are not homogeneous, and often contain subcompartments.
Speaker 2 of 6
Julia Mahamid, European Molecular Biology Laboratory, Germany
Visualizing the Structural Basis of Liquid-Like Stress Granules in situ

Thursday, April 11 | 5:00PM - 7:00PM
Structure and Substructure of Biomolecular Condensates
Room: Ballroom 2-3
To introduce the idea that many condensates are not homogeneous, and often contain subcompartments.
Speaker 3 of 6
Haiyang Yu, Ludwig Institute for Cancer Research, USA
Short Talk: Molecular and Structural Mechanisms for Intranuclear Tertiary Phase Separation of TDP-43 Liquid Droplets

Thursday, April 11 | 5:00PM - 7:00PM
Structure and Substructure of Biomolecular Condensates
Room: Ballroom 2-3
To introduce the idea that many condensates are not homogeneous, and often contain subcompartments.
Speaker 4 of 6
Abby F. Dernburg, University of California, Berkeley, USA
Pattern Formation within a Liquid Crystalline Compartment Regulates Meiotic Recombination

Thursday, April 11 | 5:00PM - 7:00PM
Structure and Substructure of Biomolecular Condensates
Room: Ballroom 2-3
To introduce the idea that many condensates are not homogeneous, and often contain subcompartments.
Speaker 5 of 6
Geeta J. Narlikar, University of California, San Francisco, USA
Phase-Separation Mechanisms in Heterochromatin

Thursday, April 11 | 5:00PM - 7:00PM
Structure and Substructure of Biomolecular Condensates
Room: Ballroom 2-3
To introduce the idea that many condensates are not homogeneous, and often contain subcompartments.
Speaker 6 of 6
Wen Zhou, Harvard Medical School, USA
Short Talk: Mechanism of Human cGAS Activation and Regulation

Thursday, April 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Thursday, April 11 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby/Wasatch


Friday, April 12 | 7:30AM - 8:30AM
Breakfast
Room: Golden Cliff/Eagles


Friday, April 12 | 8:30AM - 11:45AM
Biochemical and Biological Function of Biomolecular Condensa
tes

Room: Ballroom 2-3
To highlight current understanding of the functions of biomolecular condensates.
Speaker 1 of 10
* Amy Gladfelter, University of North Carolina at Chapel Hill, USA

Friday, April 12 | 8:30AM - 11:45AM
Biochemical and Biological Function of Biomolecular Condensa
tes

Room: Ballroom 2-3
To highlight current understanding of the functions of biomolecular condensates.
Speaker 2 of 10
J. Paul Taylor, St. Jude Children's Research Hospital, USA
Cooperative Interactions between G3BP1 and mRNA Permit Phase Separation that Seeds the Assembly of Stress Granules

Friday, April 12 | 8:30AM - 11:45AM
Biochemical and Biological Function of Biomolecular Condensa
tes

Room: Ballroom 2-3
To highlight current understanding of the functions of biomolecular condensates.
Speaker 3 of 10
Sindhuja Sridharan, European Molecular Biology Laboratory, Germany
Short Talk: The Many Roles of ATP in Organizing the Cellular Proteome

Friday, April 12 | 8:30AM - 11:45AM
Biochemical and Biological Function of Biomolecular Condensa
tes

Room: Ballroom 2-3
To highlight current understanding of the functions of biomolecular condensates.
Speaker 4 of 10
Lucas Pelkmans, University of Zürich, Switzerland
Molecular Regulators of Macromolecular Phase Separation

Friday, April 12 | 8:30AM - 11:45AM
Biochemical and Biological Function of Biomolecular Condensa
tes

Room: Ballroom 2-3
To highlight current understanding of the functions of biomolecular condensates.

Coffee Break

Friday, April 12 | 8:30AM - 11:45AM
Biochemical and Biological Function of Biomolecular Condensa
tes

Room: Ballroom 2-3
To highlight current understanding of the functions of biomolecular condensates.
Speaker 6 of 10
Geraldine Seydoux, Johns Hopkins School of Medicine, USA
Recruitment of RNA to RNA Granules by Intrinsically-Disordered Proteins


Friday, April 12 | 8:30AM - 11:45AM
Biochemical and Biological Function of Biomolecular Condensa
tes

Room: Ballroom 2-3
To highlight current understanding of the functions of biomolecular condensates.
Speaker 7 of 10
Anatol W. Fritsch, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Short Talk: The Heat is On: Controlling Germ Granule Segregation in C. elegans

Friday, April 12 | 8:30AM - 11:45AM
Biochemical and Biological Function of Biomolecular Condensa
tes

Room: Ballroom 2-3
To highlight current understanding of the functions of biomolecular condensates.
Speaker 8 of 10
Elio Aaron Abbondanzieri, University of Rochester, USA
Short Talk: A Bacterial DNA-Binding Protein Forms Liquid Crystalline Complexes with DNA Capable of Supporting Unimpeded Transcription

Friday, April 12 | 8:30AM - 11:45AM
Biochemical and Biological Function of Biomolecular Condensa
tes

Room: Ballroom 2-3
To highlight current understanding of the functions of biomolecular condensates.
Speaker 9 of 10
Songon An, University of Maryland, Baltimore County, USA
Short Talk: Membraneless Metabolic Granules for Glucose Metabolism and Their Functional Contributions to Cellular Metabolism in Living Cells: The Glucosome

Friday, April 12 | 8:30AM - 11:45AM
Biochemical and Biological Function of Biomolecular Condensa
tes

Room: Ballroom 2-3
To highlight current understanding of the functions of biomolecular condensates.
Speaker 10 of 10
Oliver Mueller-Cajar, Nanyang Technological University, Singapore
Short Talk: The Distinct Phase Separations Underlying Diverse Pyrenoids- the CO2-Fixing Membraneless Organelles of Green Algae and Diatoms

Friday, April 12 | 11:45AM - 12:45PM
NIH Grant Writing

Speaker 1 of 2
Ian M. Fingerman, NCI, National Institutes of Health, USA

Friday, April 12 | 11:45AM - 12:45PM
NIH Grant Writing

Speaker 2 of 2
John Satterlee, NIDA, National Institutes of Health, USA

Friday, April 12 | 11:45AM - 5:00PM
On Own for Lunch


Friday, April 12 | 11:45AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Friday, April 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Friday, April 12 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Friday, April 12 | 5:00PM - 7:00PM
New Phase Separating Systems
Room: Ballroom 2-3
To describe recently discovered phase separating systems, beyond canonical RNA granules and signaling clusters.
Speaker 1 of 6
* Lucas Pelkmans, University of Zürich, Switzerland

Friday, April 12 | 5:00PM - 7:00PM
New Phase Separating Systems
Room: Ballroom 2-3
To describe recently discovered phase separating systems, beyond canonical RNA granules and signaling clusters.
Speaker 2 of 6
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Transcriptional Condensates and Control of Cell Identity

Friday, April 12 | 5:00PM - 7:00PM
New Phase Separating Systems
Room: Ballroom 2-3
To describe recently discovered phase separating systems, beyond canonical RNA granules and signaling clusters.
Speaker 3 of 6
Arnaud Hubstenberger, Institute of Biology Valrose, France
Multiscale and Multiphase Organization of the Transcriptome during Development and in Response to the Environment in C. elegans

Friday, April 12 | 5:00PM - 7:00PM
New Phase Separating Systems
Room: Ballroom 2-3
To describe recently discovered phase separating systems, beyond canonical RNA granules and signaling clusters.
Speaker 4 of 6
Marina Feric, NCI, National Institutes of Health, USA
Short Talk: Condensing the Mitochondrial Genome into Gel-Like Droplets

Friday, April 12 | 5:00PM - 7:00PM
New Phase Separating Systems
Room: Ballroom 2-3
To describe recently discovered phase separating systems, beyond canonical RNA granules and signaling clusters.
Speaker 5 of 6
Pallavi Gopal, Yale School of Medicine, USA
Spatiotemporal Dynamics of TDP-43 Ribonucleoprotein Granules in Neuronal Physiology and Pathologic Transitions in Disease

Friday, April 12 | 5:00PM - 7:00PM
New Phase Separating Systems
Room: Ballroom 2-3
To describe recently discovered phase separating systems, beyond canonical RNA granules and signaling clusters.
Speaker 6 of 6
Yacheng Liao, HHMI Janelia Research Institute, USA
Short Talk: RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

Friday, April 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Friday, April 12 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby/Wasatch


Saturday, April 13 | 7:30AM - 8:30AM
Breakfast
Room: Golden Cliff/Eagles


Saturday, April 13 | 8:30AM - 11:30AM
Specificity
Room: Ballroom 2-3
To illustrate our current understanding of the factors that determine the recruitment of specific proteins and RNA molecules into particular biomolecular condensates.
Speaker 1 of 9
* Geraldine Seydoux, Johns Hopkins School of Medicine, USA

Saturday, April 13 | 8:30AM - 11:30AM
Specificity
Room: Ballroom 2-3
To illustrate our current understanding of the factors that determine the recruitment of specific proteins and RNA molecules into particular biomolecular condensates.
Speaker 2 of 9
Ruth Lehmann, Whitehead Institute, USA
RNA Organization within Phase Transitioned Germ Granules


Saturday, April 13 | 8:30AM - 11:30AM
Specificity
Room: Ballroom 2-3
To illustrate our current understanding of the factors that determine the recruitment of specific proteins and RNA molecules into particular biomolecular condensates.
Speaker 3 of 9
Amy Gladfelter, University of North Carolina at Chapel Hill, USA
How RNA Structure Controls Specificity in Intracellular Phase Separation

Saturday, April 13 | 8:30AM - 11:30AM
Specificity
Room: Ballroom 2-3
To illustrate our current understanding of the factors that determine the recruitment of specific proteins and RNA molecules into particular biomolecular condensates.
Speaker 4 of 9
Wenmin Xing, University of Texas Southwestern Medical Center, USA
Short Talk: A Quantitative Inventory of Yeast P Body Proteins Reveals Principles of Compositional Specificity

Saturday, April 13 | 8:30AM - 11:30AM
Specificity
Room: Ballroom 2-3
To illustrate our current understanding of the factors that determine the recruitment of specific proteins and RNA molecules into particular biomolecular condensates.

Coffee Break

Saturday, April 13 | 8:30AM - 11:30AM
Specificity
Room: Ballroom 2-3
To illustrate our current understanding of the factors that determine the recruitment of specific proteins and RNA molecules into particular biomolecular condensates.
Speaker 6 of 9
Florian Stengel, University of Konstanz, Germany
Short Talk: Mass Spectrometry-Based Proteomics for the Structural Characterisation of Biomolecular Condensates

Saturday, April 13 | 8:30AM - 11:30AM
Specificity
Room: Ballroom 2-3
To illustrate our current understanding of the factors that determine the recruitment of specific proteins and RNA molecules into particular biomolecular condensates.
Speaker 7 of 9
Maria Hondele, Institute of Biochemistry, Switzerland
Short Talk: DEAD-box ATPases Are Global Regulators of Phase-Separated Organelles and RNA Flux

Saturday, April 13 | 8:30AM - 11:30AM
Specificity
Room: Ballroom 2-3
To illustrate our current understanding of the factors that determine the recruitment of specific proteins and RNA molecules into particular biomolecular condensates.
Speaker 8 of 9
Ibrahim Cissé, Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Live Mammalian Cells

Saturday, April 13 | 8:30AM - 11:30AM
Specificity
Room: Ballroom 2-3
To illustrate our current understanding of the factors that determine the recruitment of specific proteins and RNA molecules into particular biomolecular condensates.
Speaker 9 of 9
Akinori Yamasaki, Institute of Microbial Chemistry, Japan
Short Talk: Functional and Molecular Insights into Selective Autophagy of Phase Separated Cargo

Saturday, April 13 | 11:30AM - 5:00PM
On Own for Lunch


Saturday, April 13 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Saturday, April 13 | 5:00PM - 6:45PM
Cell Stress and Disease
Room: Ballroom 2-3
To explain how aberrant condensates may lead to human disease.
Speaker 1 of 5
* Anthony Hyman, Max Planck Institute of Molecular Cell Biology & Genetics, Germany

Saturday, April 13 | 5:00PM - 6:45PM
Cell Stress and Disease
Room: Ballroom 2-3
To explain how aberrant condensates may lead to human disease.
Speaker 2 of 5
Christine Mayr, Memorial Sloan Kettering Cancer Center, USA
TIS Granules Enable the Formation of Specific Protein-Protein Interactions

Saturday, April 13 | 5:00PM - 6:45PM
Cell Stress and Disease
Room: Ballroom 2-3
To explain how aberrant condensates may lead to human disease.
Speaker 3 of 5
D. Allan Drummond, University of Chicago, USA
Phase Separation as an Adaptive Response to Cell Stress

Saturday, April 13 | 5:00PM - 6:45PM
Cell Stress and Disease
Room: Ballroom 2-3
To explain how aberrant condensates may lead to human disease.
Speaker 4 of 5
Simon Alberti, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
A Phosphorylation-Controlled Conformational Switch Drives Stress Granule Formation by Unlocking RNA Multivalency

Saturday, April 13 | 5:00PM - 6:45PM
Cell Stress and Disease
Room: Ballroom 2-3
To explain how aberrant condensates may lead to human disease.
Speaker 5 of 5
Jay W. Schneider, University of Texas Southwestern Medical Center, USA
Short Talk: Pathogenic Biomolecular Condensates Drive Heart Failure in Human RBM20 Cardiomyopathy Gene-Edited Pigs

Saturday, April 13 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Ballroom 2-3


Saturday, April 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 1
No registration fees are used to fund alcohol served at this function.

Saturday, April 13 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 1
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Saturday, April 13 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 1


Sunday, April 14 | 10:24AM - 10:24AM
Departure


*Session Chair.