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Web Desc
Immunometabolism, Metaflammation and Metabolic Disorders
Organizer(s): Gökhan S. Hotamisligil, Ruslan M. Medzhitov and Karine Clément
Date: April 14 - 18, 2019
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Supported by the Directors' Fund
Summary of Meeting:
Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlie the emergence of many pathologies, particularly chronic non-communicable diseases such as obesity and diabetes. Understanding the complex immunometabolic signaling networks and the cellular and molecular events that occur in the setting of altered nutrient and energy exposures has the potential to lead to tangible therapeutic advancements to promote health. This conference will engage scientists at the forefront of the efforts to translate this biology into clinical approaches, to discuss the successes and limitations of this work so far. This conference will cover the molecular mechanisms and physiological outcomes of immunometabolic interactions in the context of chronic metabolic diseases. Topics will range from the most evolutionarily conserved interactions studied in model organisms to human studies. There will be two sessions devoted to translational paths, covering both opportunities and challenges. Overall, this symposium will be an opportunity for experts in the fields of immunology and metabolism to come together to discuss and share their diverse perspectives on the integration of metabolism and immunity.
Scholarship Deadline: December 18 2018
Discounted Abstract Deadline: December 18 2018
Abstract Deadline: January 15 2019
Discounted Registration Deadline: February 12 2019
We gratefully acknowledge additional support from these exhibitors at this conference:
MilliporeSigma
We gratefully acknowledge additional support for this conference from:
GeneTex, Inc.InSphero Inc.Sabri Ülker Foundation
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK121500-01
Funding for this conference was made possible (in part) by 1R13DK121500-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 14 | 4:00PM - 8:00PM
Arrival and Registration
Room: British/Columbia Foyer


Sunday, April 14 | 6:00PM - 8:00PM
Welcome Mixer
Room: British/Columbia Foyer
No registration fees are used to fund alcohol served at this function.

Monday, April 15 | 7:30AM - 8:30AM
Breakfast
Room: Pacific Ballroom


Monday, April 15 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: British/Columbia Ballroom

Speaker 1 of 2
* Gökhan S. Hotamisligil, Harvard School of Public Health, USA

Monday, April 15 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: British/Columbia Ballroom

Speaker 2 of 2
Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
C. elegans Surveillance of Conserved Cellular Components to Detect and Defend Pathogen Attacks, Real or Imagined

Monday, April 15 | 9:30AM - 12:00PM
Immunometabolic Framework in Model Organisms
Room: British/Columbia Ballroom

Speaker 1 of 6
Laura Palanker Musselman, Binghamton University, USA
Increased Infection Susceptibility in Drosophila Insulin Resistance

Monday, April 15 | 9:30AM - 12:00PM
Immunometabolic Framework in Model Organisms
Room: British/Columbia Ballroom


Coffee Break

Monday, April 15 | 9:30AM - 12:00PM
Immunometabolic Framework in Model Organisms
Room: British/Columbia Ballroom

Speaker 3 of 6
Heinrich Jasper, Genentech, Inc., USA
Control of Metabolic and Immune Homeostasis by MANF

Monday, April 15 | 9:30AM - 12:00PM
Immunometabolic Framework in Model Organisms
Room: British/Columbia Ballroom

Speaker 4 of 6
Antje Körner, University Children's Hospital Leipzig, Germany
Exploring Factors for Adipocyte Development and Adaptation in Human and Zebrafish

Monday, April 15 | 9:30AM - 12:00PM
Immunometabolic Framework in Model Organisms
Room: British/Columbia Ballroom

Speaker 5 of 6
Bruno Guigas, Leiden University Medical Center, Netherlands
Short Talk: Phenotypically Distinct Alternatively-Activated Adipose Tissue Macrophages Induced by Helminth Molecules Differently Impact Metabolic Homeostasis

Monday, April 15 | 9:30AM - 12:00PM
Immunometabolic Framework in Model Organisms
Room: British/Columbia Ballroom

Speaker 6 of 6
* Sally A. Clayton, University of Birmingham, UK
Short Talk: Electron Transport Chain Protein NDUFA4 is Regulated by Inflammatory Stimuli in Macrophages

Monday, April 15 | 12:00PM - 5:00PM
On Own for Lunch


Monday, April 15 | 12:00PM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Monday, April 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Monday, April 15 | 2:30PM - 4:30PM
Workshop: Immunometabolic Regulators
Room: British/Columbia Ballroom

Speaker 1 of 8
* Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA

Monday, April 15 | 2:30PM - 4:30PM
Workshop: Immunometabolic Regulators
Room: British/Columbia Ballroom

Speaker 2 of 8
Duale A. Ahmed, Carleton University, Canada
Differential Modulation of Complex III Expression in Poly(I:C)-stimulated Macrophages Amplifies Interferon Signaling and Responses

Monday, April 15 | 2:30PM - 4:30PM
Workshop: Immunometabolic Regulators
Room: British/Columbia Ballroom

Speaker 3 of 8
Elizabeth Floyd, Pennington Biomedical Research Center, USA
Siah2 Contributes to Sex-Specific Remodeling of Metabolic and Inflammatory Signaling in Adipose Tissue

Monday, April 15 | 2:30PM - 4:30PM
Workshop: Immunometabolic Regulators
Room: British/Columbia Ballroom

Speaker 4 of 8
Anetta Svitorka Härtlova, University of Gothenburg, Sweden
MSR1 Triggers JNK-Mediated Lipid-Induced Inflammation and Promotes Obesity-Related Non-Alcoholic Liver Disease

Monday, April 15 | 2:30PM - 4:30PM
Workshop: Immunometabolic Regulators
Room: British/Columbia Ballroom

Speaker 5 of 8
Bastiaan Werner Lennert Maes, Ghent University VIB, Belgium
TAOK3 Modulates the Presence of T1ST2 T Regulatory Cells in Murine Obesity

Monday, April 15 | 2:30PM - 4:30PM
Workshop: Immunometabolic Regulators
Room: British/Columbia Ballroom

Speaker 6 of 8
Atsuko Nakatsuka, Okayama University Graduate School of Medicine, Japan
Vaspin Regulates Lysosome Function and Protects from Tubulopathy in Metabolic Syndrome

Monday, April 15 | 2:30PM - 4:30PM
Workshop: Immunometabolic Regulators
Room: British/Columbia Ballroom

Speaker 7 of 8
Christoph Wilhelm, University of Bonn, Germany
Lipid Droplet Formation Fuels Pathogenic ILC2 Responses in Airway Inflammation

Monday, April 15 | 2:30PM - 4:30PM
Workshop: Immunometabolic Regulators
Room: British/Columbia Ballroom

Speaker 8 of 8
Andreas Bergthaler, Austrian Academy of Sciences, Austria
CD8 T Cells Induce Cachexia in Chronic Viral Infection

Monday, April 15 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Monday, April 15 | 5:00PM - 7:00PM
Components of Immunometabolic Interactions
Room: British/Columbia Ballroom

Speaker 1 of 5
Anna Mae Diehl, Duke University, USA
Immune Regulation of Liver Function and Response to Injury

Monday, April 15 | 5:00PM - 7:00PM
Components of Immunometabolic Interactions
Room: British/Columbia Ballroom

Speaker 2 of 5
Ajay Chawla, Merck Research Labs, USA
Tissue Resident Macrophages in Metabolic Disease

Monday, April 15 | 5:00PM - 7:00PM
Components of Immunometabolic Interactions
Room: British/Columbia Ballroom

Speaker 3 of 5
Michael P. Czech, University of Massachusetts Medical School, USA
Immune Interactions that Drive Adipocyte Form and Function

Monday, April 15 | 5:00PM - 7:00PM
Components of Immunometabolic Interactions
Room: British/Columbia Ballroom

Speaker 4 of 5
Julie E. Gibbs, University of Manchester, UK
Short Talk: How Chronic Inflammatory Disease Affects Temporal Dynamics of the Gut Microbiome

Monday, April 15 | 5:00PM - 7:00PM
Components of Immunometabolic Interactions
Room: British/Columbia Ballroom

Speaker 5 of 5
* Agnieszka M. Kabat, Max Planck Institute of Immunobiology and Epigenetics, Germany
Short Talk: Adaptive Type 2 Responses in Mucosa-Associated Adipose Tissue

Monday, April 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, April 15 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Tuesday, April 16 | 7:30AM - 8:30AM
Breakfast
Room: Pacific Ballroom


Tuesday, April 16 | 8:30AM - 11:45AM
Immunometabolic Positioning of Innate versus Adaptive Immune
Cells

Room: British/Columbia Ballroom

Speaker 1 of 8
Agnès C. Lehuen, Institut Cochin, France
MAIT Cells at the Crossroad of Microbiota, Inflammation and Diabetes

Tuesday, April 16 | 8:30AM - 11:45AM
Immunometabolic Positioning of Innate versus Adaptive Immune
Cells

Room: British/Columbia Ballroom

Speaker 2 of 8
Barbara S. Nikolajczyk, University of Kentucky College of Medicine, USA
Mitochondrial Changes Synergize with Long Chain Fatty Acid Derivatives to Support Th17 Inflammation in Diabetes

Tuesday, April 16 | 8:30AM - 11:45AM
Immunometabolic Positioning of Innate versus Adaptive Immune
Cells

Room: British/Columbia Ballroom


Coffee Break

Tuesday, April 16 | 8:30AM - 11:45AM
Immunometabolic Positioning of Innate versus Adaptive Immune
Cells

Room: British/Columbia Ballroom

Speaker 4 of 8
Diane Mathis, Harvard Medical School, USA
Adipose Tissue T-Regulatory Cells

Tuesday, April 16 | 8:30AM - 11:45AM
Immunometabolic Positioning of Innate versus Adaptive Immune
Cells

Room: British/Columbia Ballroom

Speaker 5 of 8
Alexander Bartelt, Ludwig-Maximilians-University, Germany
Nfe2l1-Mediated Proteasomal Activity Secures ER Function in Adipocytes and Protects from Insulin Resistance in Mice and Humans

Tuesday, April 16 | 8:30AM - 11:45AM
Immunometabolic Positioning of Innate versus Adaptive Immune
Cells

Room: British/Columbia Ballroom

Speaker 6 of 8
Elodie Picarda, Albert Einstein College of Medicine, USA
Short Talk: The Immune Checkpoint B7-H3 (CD276) Protects against Obesity

Tuesday, April 16 | 8:30AM - 11:45AM
Immunometabolic Positioning of Innate versus Adaptive Immune
Cells

Room: British/Columbia Ballroom

Speaker 7 of 8
* Lin Wu, Skirball Institute, NYU School of Medicine, USA
Short Talk: Selective Redundancy in Metabolism Network Allows Specific in vivo Inhibition of Inflammatory but Not Homeostatic Th17 Cells

Tuesday, April 16 | 8:30AM - 11:45AM
Immunometabolic Positioning of Innate versus Adaptive Immune
Cells

Room: British/Columbia Ballroom

Speaker 8 of 8
Julian M. Yabut, McMaster University, Canada
Short Talk: Inhibition of Mast Cell Serotonin Synthesis Reduces Obesity and Insulin Resistance by Potentiation of White Adipose Tissue Browning in Mice

Tuesday, April 16 | 11:45AM - 5:00PM
On Own for Lunch


Tuesday, April 16 | 11:45AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Tuesday, April 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Tuesday, April 16 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Tuesday, April 16 | 5:00PM - 7:00PM
Signaling Networks Regulating Immunometabolic Responses
Room: British/Columbia Ballroom

Speaker 1 of 4
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Interfacing Immune Response and Metabolism

Tuesday, April 16 | 5:00PM - 7:00PM
Signaling Networks Regulating Immunometabolic Responses
Room: British/Columbia Ballroom

Speaker 2 of 4
Roger J. Davis, HHMI/University of Massachusetts Medical School, USA
Stress Signaling Pathways in Immunometabolism

Tuesday, April 16 | 5:00PM - 7:00PM
Signaling Networks Regulating Immunometabolic Responses
Room: British/Columbia Ballroom

Speaker 3 of 4
Vishwa Deep Dixit, Yale University, USA
Aging and the Metabolic Inflammasome

Tuesday, April 16 | 5:00PM - 7:00PM
Signaling Networks Regulating Immunometabolic Responses
Room: British/Columbia Ballroom

Speaker 4 of 4
* Maria Luisa Balmer, University Basel, Switzerland
Short Talk: Accumulation of Acetate at Sites of Infection Improves Pathogen Clearance and Protects from Immunopathology
by Re-Programming Memory CD8+ T Cells


Tuesday, April 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, April 16 | 7:30PM - 10:00PM
Poster Session 2
Room: Pacific Ballroom


Wednesday, April 17 | 7:30AM - 8:30AM
Breakfast
Room: Pacific Ballroom


Wednesday, April 17 | 8:30AM - 11:45AM
Organelle Dynamics and Function in Immunometabolism
Room: British/Columbia Ballroom

Speaker 1 of 8
Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Immunometabolic Components of Age- and Obesity-Associated Pathologies

Wednesday, April 17 | 8:30AM - 11:45AM
Organelle Dynamics and Function in Immunometabolism
Room: British/Columbia Ballroom

Speaker 2 of 8
Gerald S. Shadel, The Salk Institute for Biological Studies, USA
Adaptive Responses to Mitochondrial Stress

Wednesday, April 17 | 8:30AM - 11:45AM
Organelle Dynamics and Function in Immunometabolism
Room: British/Columbia Ballroom


Coffee Break

Wednesday, April 17 | 8:30AM - 11:45AM
Organelle Dynamics and Function in Immunometabolism
Room: British/Columbia Ballroom

Speaker 4 of 8
Shawn C. Burgess, University of Texas Southwestern Medical Center, USA
Mitochondrial Metabolism in Fatty Liver Disease

Wednesday, April 17 | 8:30AM - 11:45AM
Organelle Dynamics and Function in Immunometabolism
Room: British/Columbia Ballroom

Speaker 5 of 8
Ling Yang, University of Iowa, USA
Lysosomal Nitric Oxide Bioactivity Contributes to Obesity-Associated Insulin Resistance


Wednesday, April 17 | 8:30AM - 11:45AM
Organelle Dynamics and Function in Immunometabolism
Room: British/Columbia Ballroom

Speaker 6 of 8
Aparajita Madhavan, The Scripps Research Institute, USA
Short Talk:Pharmacologic targeting of IRE1 Signaling to Alleviate Metabolic Dysfunction

Wednesday, April 17 | 8:30AM - 11:45AM
Organelle Dynamics and Function in Immunometabolism
Room: British/Columbia Ballroom

Speaker 7 of 8
Feyza Engin, University of Wisconsin-Madison, USA
Short Talk: Beta Cell IRE1a Deficiency Protects Mice Against Type 1 Diabetes

Wednesday, April 17 | 8:30AM - 11:45AM
Organelle Dynamics and Function in Immunometabolism
Room: British/Columbia Ballroom

Speaker 8 of 8
* Guang Gao, University of British Columbia, Canada
Short Talk: STED Super-Resolution Microscopy Reveals Reticulon and CLIMP-63 Dependent Peripheral ER Tubule Nanodomain Organization

Wednesday, April 17 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, April 17 | 11:45AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Wednesday, April 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Wednesday, April 17 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Wednesday, April 17 | 5:00PM - 7:15PM
Nutrients and Metabolites Critical for Immunometabolic Respo
nses

Room: British/Columbia Ballroom

Speaker 1 of 6
Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Immunometabolic Regulation by Novel Lipid Species

Wednesday, April 17 | 5:00PM - 7:15PM
Nutrients and Metabolites Critical for Immunometabolic Respo
nses

Room: British/Columbia Ballroom

Speaker 2 of 6
Christopher K. Glass, University of California, San Diego, USA
Roles of Tissue Environment in Shaping Macrophage Identities

Wednesday, April 17 | 5:00PM - 7:15PM
Nutrients and Metabolites Critical for Immunometabolic Respo
nses

Room: British/Columbia Ballroom

Speaker 3 of 6
Tony K.T. Lam, Toronto General Research Institute, Canada
Nutrient Sensing in the Gut

Wednesday, April 17 | 5:00PM - 7:15PM
Nutrients and Metabolites Critical for Immunometabolic Respo
nses

Room: British/Columbia Ballroom

Speaker 4 of 6
Benan Pelin Sermikli, Institute of Pasteur Lille, France
Short Talk: Role of Myeloid-Expressed RORa in Metabolic Diseases

Wednesday, April 17 | 5:00PM - 7:15PM
Nutrients and Metabolites Critical for Immunometabolic Respo
nses

Room: British/Columbia Ballroom

Speaker 5 of 6
* Jaswinder K. Sethi, University of Southamptom, UK
Short Talk: Inflammation-Linked Adaptations in Dermal Microvascular Reactivity Accompany the Development of Obesity and Type 2 Diabetes

Wednesday, April 17 | 5:00PM - 7:15PM
Nutrients and Metabolites Critical for Immunometabolic Respo
nses

Room: British/Columbia Ballroom

Speaker 6 of 6
Martin Valdearcos, University of California, San Francisco, USA
Short Talk: Microglia Mediate Neonatal Weight Gain and Early-Life Programming of Adult Glucose Control

Wednesday, April 17 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Pacific Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, April 17 | 7:30PM - 10:00PM
Poster Session 3
Room: Pacific Ballroom


Thursday, April 18 | 7:30AM - 8:30AM
Breakfast
Room: Pacific Ballroom


Thursday, April 18 | 8:30AM - 11:30AM
Translation of Immunometabolism
Room: British/Columbia Ballroom

Speaker 1 of 7
Marc Y. Donath, University Hospital Basel, Switzerland
Targeting Inflammation in Metabolic Disease

Thursday, April 18 | 8:30AM - 11:30AM
Translation of Immunometabolism
Room: British/Columbia Ballroom

Speaker 2 of 7
Armelle Yart, INSERM, France
Study on Rare Disease Uncovers New Determinants of Inflammation-Dependent Insulin Resistance

Thursday, April 18 | 8:30AM - 11:30AM
Translation of Immunometabolism
Room: British/Columbia Ballroom


Coffee Break

Thursday, April 18 | 8:30AM - 11:30AM
Translation of Immunometabolism
Room: British/Columbia Ballroom

Speaker 4 of 7
Elif A. Oral, University of Michigan, USA
Crosstalk Between Metabolic and Immune Signals at the Sites of Energy Storage: Translational Lessons

Thursday, April 18 | 8:30AM - 11:30AM
Translation of Immunometabolism
Room: British/Columbia Ballroom

Speaker 5 of 7
Lale Ozcan, Columbia University, USA
Short Talk: Regulation of LDL-Cholesterol by Glucagon-Mediated Lysosomal Degradation of PCSK9

Thursday, April 18 | 8:30AM - 11:30AM
Translation of Immunometabolism
Room: British/Columbia Ballroom

Speaker 6 of 7
* Kacey J. Prentice, Harvard University, USA
Short Talk: Targeting Circulating FABP4 Prevents Type 1 Diabetes by Promoting ß Cell Function and Survival

Thursday, April 18 | 8:30AM - 11:30AM
Translation of Immunometabolism
Room: British/Columbia Ballroom

Speaker 7 of 7
Emma Borgeson, University of Gothenburg, Sweden
Short Talk: Therapeutic Potential of Pro-Resolving Lipids in Human Cardiometabolic Disease

Thursday, April 18 | 11:30AM - 5:00PM
On Own for Lunch


Thursday, April 18 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Thursday, April 18 | 5:00PM - 6:45PM
Immunometabolic Links in Human Studies
Room: British/Columbia Ballroom

Speaker 1 of 4
* Karine Clément, INSERM / Sorbonne Universite, France
The Role of Microbiota in Human Metabolic Disease

Thursday, April 18 | 5:00PM - 6:45PM
Immunometabolic Links in Human Studies
Room: British/Columbia Ballroom

Speaker 2 of 4
Gerald I. Shulman, Yale University School of Medicine, USA
Linking White Adipocyte Inflammation to Alterations in Hepatic Mitochondrial Metabolism and Type 2 Diabetes

Thursday, April 18 | 5:00PM - 6:45PM
Immunometabolic Links in Human Studies
Room: British/Columbia Ballroom

Speaker 3 of 4
Evan D. Rosen, Harvard University, USA
Multifunctional Roles of Interferon Regulatory Factors (IRFs) in Metabolism

Thursday, April 18 | 5:00PM - 6:45PM
Immunometabolic Links in Human Studies
Room: British/Columbia Ballroom

Speaker 4 of 4
Esperanza Perucha, King's College London, UK
Short Talk: The Cholesterol Biosynthesis Pathway Regulates IL-10 Expression in Human CD4+ T Cells

Thursday, April 18 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: British/Columbia Ballroom


Thursday, April 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, April 18 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, April 18 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Friday, April 19 | 10:24AM - 10:24AM
Departure


*Session Chair.