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This meeting took place in the past. Here is a list of meetings that are related:
Cerebral Fluid Flow and Function: Lymphatics, Glymphatics and the Choroid Plexus (2020Q4)
Brain Therapeutics: Disruptive Technologies and Opportunities (2020Q3)
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Web Desc
Delivering Therapeutics Across Biological Barriers
Organizer(s): David Brayden, Claus-Michael Lehr and Kathryn Whitehead
Date: May 06 - 09, 2019
Location: Royal Dublin Society, Dublin 4, Ireland
Organized in Collaboration with Science Foundation Ireland
Sponsored by Astellas Pharma Inc.
Summary of Meeting:
The multi-disciplinary theme of crossing of biological barriers encompasses biology, chemistry, pharmaceutical formulation, polymeric and materials science, advanced cell biology, imaging, microfluidics, and drug-device combination research. This conference occurs at the interface between cell biology and the use of technologies to exploit such understanding in order to translate therapies to patients. The program comprises leading researchers from academia, institutes, as well as from the pharmaceutical and medical device industry. The goal of the conference is to profile cutting edge research in specific areas of achieving drug delivery across biological barriers where a large translational impact would result for both industry and patients. By inviting cell biologists, technology developers, and formulators to the same conference, this will provide in depth discussions and offer a thorough perspective on the tissue and cell barriers that must be crossed in order to help guide technology approaches to achieve these breakthrough treatments.
Scholarship Deadline: January 8 2019
Discounted Abstract Deadline: January 8 2019
Abstract Deadline: February 6 2019
Discounted Registration Deadline: March 6 2019
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
We gratefully acknowledge additional support for this conference from:
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
AstraZeneca
We gratefully acknowledge the generous grant for this conference provided by:
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Grant No. 1R13EB028133-01
Funding for this conference was made possible (in part) by 1R13EB028133-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
Program
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Monday, May 06
| 4:00PM - 8:00PM
Arrival and Registration
Room: Concert Hall Foyer
Monday, May 06
| 6:00PM - 8:00PM
Welcome Mixer
Room: Hall 6
No registration fees are used to fund alcohol served at this function.
Tuesday, May 07
| 8:00AM - 8:30AM
Poster Setup
Room: Hall 6
Tuesday, May 07
| 8:30AM - 7:00PM
Poster Viewing
Room: Hall 6
Tuesday, May 07
| 8:30AM - 8:40AM
Welcoming Remarks (Organizers)
Tuesday, May 07
| 8:40AM - 11:30AM
Delivery Across Mucosal Sites: Oral and Pulmonary
Room: Concert Hall
Speaker 1 of 8
* Claus-Michael Lehr
, Helmholtz-Institute for Pharmaceutical Research Saarland, Germany
Tuesday, May 07
| 8:40AM - 11:30AM
Delivery Across Mucosal Sites: Oral and Pulmonary
Room: Concert Hall
Speaker 2 of 8
David Brayden
, University College Dublin, Ireland
Oral Peptide Delivery Using Intestinal Permeation Enhancers and Nanoparticle Technology
Tuesday, May 07
| 8:40AM - 11:30AM
Delivery Across Mucosal Sites: Oral and Pulmonary
Room: Concert Hall
Speaker 3 of 8
Stephen Timothy Buckley
, Novo Nordisk A/S, Denmark
Short Talk: Gastric Absorption of a Fatty Acid-Acylated Analog of Glucagon-Like Peptide-1 (GLP-1)
Tuesday, May 07
| 8:40AM - 11:30AM
Delivery Across Mucosal Sites: Oral and Pulmonary
Room: Concert Hall
Speaker 4 of 8
Anja Boisen
, Technical University of Denmark, Denmark
Oral Drug Delivery Using Micro Devices
Tuesday, May 07
| 8:40AM - 11:30AM
Delivery Across Mucosal Sites: Oral and Pulmonary
Room: Concert Hall
Coffee Break
Tuesday, May 07
| 8:40AM - 11:30AM
Delivery Across Mucosal Sites: Oral and Pulmonary
Room: Concert Hall
Speaker 6 of 8
Chris Porter
, Monash University, Australia
Lipidated Drugs and Lipid-Based Formulations to Improve Solubility and Oral Bioavailability of BCS Class II Molecules
Tuesday, May 07
| 8:40AM - 11:30AM
Delivery Across Mucosal Sites: Oral and Pulmonary
Room: Concert Hall
Speaker 7 of 8
Anthony J. Hickey
, University of North Carolina at Chapel Hill, USA
Biopharmaceutical Considerations in Pulmonary Drug Delivery
Tuesday, May 07
| 8:40AM - 11:30AM
Delivery Across Mucosal Sites: Oral and Pulmonary
Room: Concert Hall
Speaker 8 of 8
Daria Anna Korejwo
, University of Fribourg, Switzerland
Short Talk: Interaction of Graphene-Related Materials with Cells of the Human Alveolar Tissue Barrier
Tuesday, May 07
| 11:30AM - 12:30PM
Lunch
Room: Hall 6
Tuesday, May 07
| 12:00PM - 2:30PM
Poster Session 1
Room: Hall 6
Tuesday, May 07
| 2:30PM - 4:30PM
Workshop 1: Nanoparticles in Discovery: Characterization and
Mode of Action
Room: Concert Hall
Speaker 1 of 6
* Caitriona O'Driscoll
, University College Cork, Ireland
Tuesday, May 07
| 2:30PM - 4:30PM
Workshop 1: Nanoparticles in Discovery: Characterization and
Mode of Action
Room: Concert Hall
Speaker 2 of 6
Kenneth A. Dawson
, University College Dublin, Ireland
Characterization Techniques for Nanoparticles
Tuesday, May 07
| 2:30PM - 4:30PM
Workshop 1: Nanoparticles in Discovery: Characterization and
Mode of Action
Room: Concert Hall
Speaker 3 of 6
Orlagh Feeney
, Monash University, Australia
Breaking Down Barriers: The Impact of Stromal Remodification on Nanoparticle Distribution in vivo
Tuesday, May 07
| 2:30PM - 4:30PM
Workshop 1: Nanoparticles in Discovery: Characterization and
Mode of Action
Room: Concert Hall
Speaker 4 of 6
Morag Rose Hunter
, AstraZeneca, UK
Investigating the Role of the Phosphatidylinositol Pathway in Lipid Nanoparticle Delivery
Tuesday, May 07
| 2:30PM - 4:30PM
Workshop 1: Nanoparticles in Discovery: Characterization and
Mode of Action
Room: Concert Hall
Speaker 5 of 6
Shrey Sindhwani
, University of Toronto, Canada
How Do Nanoparticles Enter Solid Tumours?
Tuesday, May 07
| 2:30PM - 4:30PM
Workshop 1: Nanoparticles in Discovery: Characterization and
Mode of Action
Room: Concert Hall
Speaker 6 of 6
Muthiah Manoharan
, Alnylam Pharmaceuticals, Inc., USA
Translation Aspects: The First Approved RNAi Therapeutic: Delivery of ONPATTRO (patisiran)
Tuesday, May 07
| 4:30PM - 5:00PM
Coffee Available
Room: Hall 6
Tuesday, May 07
| 5:00PM - 7:00PM
Nanoparticles and Polymers for the Efficient Crossing of Bio
logical Barriers
Room: Concert Hall
Speaker 1 of 5
Dan Peer
, University of Tel Aviv, Israel
A Universal Platform for RNA Therapeutics
Tuesday, May 07
| 5:00PM - 7:00PM
Nanoparticles and Polymers for the Efficient Crossing of Bio
logical Barriers
Room: Concert Hall
Speaker 2 of 5
Giulia Brachi
, Politecnico di Torino, Italy
Short Talk: Nanoparticles Transport in Glioblastoma from Intracranially-Administered Thermosensitive Hydrogels
Tuesday, May 07
| 5:00PM - 7:00PM
Nanoparticles and Polymers for the Efficient Crossing of Bio
logical Barriers
Room: Concert Hall
Speaker 3 of 5
Simple Kumar
, Georgia Institute of Technology, USA
Short Talk: Serum Effects on Nanoparticle-Mediated Photoporation for Enhanced Macromolecular Delivery
Tuesday, May 07
| 5:00PM - 7:00PM
Nanoparticles and Polymers for the Efficient Crossing of Bio
logical Barriers
Room: Concert Hall
Speaker 4 of 5
Renata Pasqualini
, Rutgers University, USA
Ligand-Directed Targeting and Molecular Imaging Based on Vascular Zip Codes Revealed by in vivo Phage Display
Tuesday, May 07
| 5:00PM - 7:00PM
Nanoparticles and Polymers for the Efficient Crossing of Bio
logical Barriers
Room: Concert Hall
Speaker 5 of 5
Maria J. Vicent
, Centro de Investigación Príncipe Felipe, Spain
Polypeptide-Based Conjugates as Versatile Drug Delivery Carriers
Tuesday, May 07
| 7:00PM - 7:00PM
On Own for Dinner
Wednesday, May 08
| 8:30AM - 11:45AM
Materials and Devices for Diagnostics and Therapeutic Delive
ry
Room: Concert Hall
Speaker 1 of 9
* Clive Prestidge
, University of South Australia, Australia
Wednesday, May 08
| 8:30AM - 11:45AM
Materials and Devices for Diagnostics and Therapeutic Delive
ry
Room: Concert Hall
Speaker 2 of 9
Tanja Weil
, Max Planck Institute for Polymer Research, Germany
Quantum Materials, Customized and Adaptive Macromolecules for Precision Sensing and Therapy
Wednesday, May 08
| 8:30AM - 11:45AM
Materials and Devices for Diagnostics and Therapeutic Delive
ry
Room: Concert Hall
Speaker 3 of 9
Paula T. Hammond
, Massachusetts Institute of Technology, USA
Electrostatic Assembly for Nanoparticle Targeting of Cells and Tissues
Wednesday, May 08
| 8:30AM - 11:45AM
Materials and Devices for Diagnostics and Therapeutic Delive
ry
Room: Concert Hall
Speaker 4 of 9
Crystal Shin
, Baylor College of Medicine, USA
Short Talk: Cerium Oxide Nanowafer to Treat Corneal Neovascularization
Wednesday, May 08
| 8:30AM - 11:45AM
Materials and Devices for Diagnostics and Therapeutic Delive
ry
Room: Concert Hall
Coffee Break
Wednesday, May 08
| 8:30AM - 11:45AM
Materials and Devices for Diagnostics and Therapeutic Delive
ry
Room: Concert Hall
Speaker 6 of 9
Joke A. Bouwstra
, Leiden University, Netherlands
Drug Device Combinations for Vaccine Delivery
Wednesday, May 08
| 8:30AM - 11:45AM
Materials and Devices for Diagnostics and Therapeutic Delive
ry
Room: Concert Hall
Speaker 7 of 9
Vipul Yadav
, Intract Pharma Limted, UK
Short Talk: Soteria®: Delivery of Antibodies in an Easy to Swallow Oral Pill
Wednesday, May 08
| 8:30AM - 11:45AM
Materials and Devices for Diagnostics and Therapeutic Delive
ry
Room: Concert Hall
Speaker 8 of 9
Julie A. Champion
, Georgia Institute of Technology, USA
Developing Therapeutic Protein Materials: Controlling and Understanding Protein Particle Self-Assembly
Wednesday, May 08
| 8:30AM - 11:45AM
Materials and Devices for Diagnostics and Therapeutic Delive
ry
Room: Concert Hall
Speaker 9 of 9
Cathal J. Kearney
, Royal College of Surgeons in Ireland, Ireland
Short Talk: On-Demand Delivery Scaffolds for Tissue Engineering
Wednesday, May 08
| 11:45AM - 5:00PM
On Own for Lunch
Wednesday, May 08
| 11:45AM - 1:00PM
Poster Setup
Room: Hall 6
Wednesday, May 08
| 1:00PM - 10:00PM
Poster Viewing
Room: Hall 6
Wednesday, May 08
| 4:30PM - 5:00PM
Coffee Available
Room: Hall 6
Wednesday, May 08
| 5:00PM - 7:00PM
Overcoming the Blood-Brain Barrier to Treat CNS Disease
Room: Concert Hall
Speaker 1 of 6
* Kinam Park
, Purdue University, USA
Wednesday, May 08
| 5:00PM - 7:00PM
Overcoming the Blood-Brain Barrier to Treat CNS Disease
Room: Concert Hall
Speaker 2 of 6
Carl I. Webster
, MedImmune, UK
Brain Delivery and Intracellular Sorting of Affinity Variants of the Anti-TfR Antibody OX26
Wednesday, May 08
| 5:00PM - 7:00PM
Overcoming the Blood-Brain Barrier to Treat CNS Disease
Room: Concert Hall
Speaker 3 of 6
Marco Campisi
, Politecnico di Torino, Italy
Short Talk: Model of Nanoparticles Transport Across the Human Blood-Brain Barrier Microvasculature
Wednesday, May 08
| 5:00PM - 7:00PM
Overcoming the Blood-Brain Barrier to Treat CNS Disease
Room: Concert Hall
Speaker 4 of 6
Danica Stanimirovic
, National Research Council of Canada, Canada
Novel Targets and Antibodies for Delivery of Therapeutics across the Blood-Brain Barrier
Wednesday, May 08
| 5:00PM - 7:00PM
Overcoming the Blood-Brain Barrier to Treat CNS Disease
Room: Concert Hall
Speaker 5 of 6
Florencia Natalia Linero
, VIB-University of Gent, Belgium
Short Talk: Breaking Down Barriers: Nanobodies to Deliver Therapeutics Across the Blood-Cerebrospinal Fluid Barrier
Wednesday, May 08
| 5:00PM - 7:00PM
Overcoming the Blood-Brain Barrier to Treat CNS Disease
Room: Concert Hall
Speaker 6 of 6
Matthew Campbell
, Trinity College Dublin, Ireland
Dose-Dependent Expression of Claudin-5 at the BBB
Wednesday, May 08
| 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Hall 6
No registration fees are used to fund alcohol served at this function.
Wednesday, May 08
| 7:30PM - 10:00PM
Poster Session 2
Room: Hall 6
Thursday, May 09
| 8:30AM - 11:30AM
Delivery Solutions for Gene Medicines
Room: Concert Hall
Speaker 1 of 8
* Sally-Ann Cryan
, Royal College of Surgeons in Ireland, Ireland
Thursday, May 09
| 8:30AM - 11:30AM
Delivery Solutions for Gene Medicines
Room: Concert Hall
Speaker 2 of 8
David V. Schaffer
, University of California, Berkeley, USA
Directed Evolution of New Viruses for Therapeutic Gene Delivery
Thursday, May 09
| 8:30AM - 11:30AM
Delivery Solutions for Gene Medicines
Room: Concert Hall
Speaker 3 of 8
Ross Wilson
, University of California, Berkeley, USA
Short Talk: Delivery of an Endosomolytic CRISPR-Cas9 RNP via Receptor-Mediated Endocytosis for Cell-Targeted Genome Editing
Thursday, May 09
| 8:30AM - 11:30AM
Delivery Solutions for Gene Medicines
Room: Concert Hall
Speaker 4 of 8
Khalid A. Hajj
, Carnegie Mellon University, USA
Enabling the Medicines of Tomorrow: Lipid Nanoparticles for Enhanced Co-Delivery of RNAs
Thursday, May 09
| 8:30AM - 11:30AM
Delivery Solutions for Gene Medicines
Room: Concert Hall
Coffee Break
Thursday, May 09
| 8:30AM - 11:30AM
Delivery Solutions for Gene Medicines
Room: Concert Hall
Speaker 6 of 8
Elias Fattal
, Université Paris-Sud, France
CD44-Targeted Delivery of siRNA
Thursday, May 09
| 8:30AM - 11:30AM
Delivery Solutions for Gene Medicines
Room: Concert Hall
Speaker 7 of 8
Anna K. Blakney
, Imperial College London, UK
Short Talk: The Skin You’re In: Design of Experiments Optimization of LNP saRNA Formulations in Human Skin Explants
Thursday, May 09
| 8:30AM - 11:30AM
Delivery Solutions for Gene Medicines
Room: Concert Hall
Speaker 8 of 8
Caitriona O'Driscoll
, University College Cork, Ireland
Short Talk: Formulation and Characterisation of Nanoparticles Prepared by Co-Formulation of Cationic and Anionic Amphiphilic Cyclodextrins as Promising siRNA Delivery Systems
Thursday, May 09
| 11:30AM - 5:00PM
On Own for Lunch
Thursday, May 09
| 11:30AM - 12:00PM
NIH Grant Process: From Submission to Review: A Roundtable f
or Trainees and Young Faculty
Room: Concert Hall
Speaker 1 of 1
* Bita Nakhai
, NIA, National Institutes of Health, USA
Thursday, May 09
| 2:30PM - 4:30PM
Workshop 2: Academic Drug Delivery Writing and Publishing in
Top Journals
Room: Concert Hall
Speaker 1 of 3
* Alison L. Reynolds
, University College Dublin, Ireland
Thursday, May 09
| 2:30PM - 4:30PM
Workshop 2: Academic Drug Delivery Writing and Publishing in
Top Journals
Room: Concert Hall
Speaker 2 of 3
Stephen Timothy Buckley
, Novo Nordisk A/S, Denmark
Academic Writing on Drug Delivery for Top Journals: A Case Study
Thursday, May 09
| 2:30PM - 4:30PM
Workshop 2: Academic Drug Delivery Writing and Publishing in
Top Journals
Room: Concert Hall
Speaker 3 of 3
Gonzalo Cordova
, Springer Nature B.V., Netherlands
What Editors Are Looking for in Delivery Papers
Thursday, May 09
| 4:30PM - 5:00PM
Coffee Available
Room: Hall 6
Thursday, May 09
| 5:00PM - 6:45PM
Human Cell and Tissue Models of Biological Barriers to Assis
t Translation
Room: Concert Hall
Speaker 1 of 5
* David Brayden
, University College Dublin, Ireland
Thursday, May 09
| 5:00PM - 6:45PM
Human Cell and Tissue Models of Biological Barriers to Assis
t Translation
Room: Concert Hall
Speaker 2 of 5
Claus-Michael Lehr
, Helmholtz-Institute for Pharmaceutical Research Saarland, Germany
Modeling Biological Barriers to Drug Delivery in Infection Research
Thursday, May 09
| 5:00PM - 6:45PM
Human Cell and Tissue Models of Biological Barriers to Assis
t Translation
Room: Concert Hall
Speaker 3 of 5
Ludivine Claude Delon
, University of South Australia, Australia
Short Talk: Systematic Investigation of the Effect of Shear Stress in a Microfluidic Intestine-on-a-Chip Model to Study Oral Particle Delivery
Thursday, May 09
| 5:00PM - 6:45PM
Human Cell and Tissue Models of Biological Barriers to Assis
t Translation
Room: Concert Hall
Speaker 4 of 5
Helena Kandarova
, Slovak Toxicology Society SETOX, Slovakia
Reconstructed Human Skin Equivalents to Model the Transport and Toxicology of the Skin Barrier
Thursday, May 09
| 5:00PM - 6:45PM
Human Cell and Tissue Models of Biological Barriers to Assis
t Translation
Room: Concert Hall
Speaker 5 of 5
Josué Sznitman
, Technion - Israel Institute of Technology, Israel
Advanced in vitro Lung-on-Chip Platforms for Inhalation Screening Assays
Thursday, May 09
| 6:45PM - 7:15PM
Summary and Analysis
Room: Concert Hall
Speaker 1 of 3
* David Brayden
, University College Dublin, Ireland
Thursday, May 09
| 6:45PM - 7:15PM
Summary and Analysis
Room: Concert Hall
Speaker 2 of 3
* Claus-Michael Lehr
, Helmholtz-Institute for Pharmaceutical Research Saarland, Germany
Thursday, May 09
| 6:45PM - 7:15PM
Summary and Analysis
Room: Concert Hall
Speaker 3 of 3
Kinam Park
, Purdue University, USA
An Assessment of the Current and Likely Impact of the Science of Crossing Biological Barriers on Medicine
Thursday, May 09
| 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Hall 6
No registration fees are used to fund alcohol served at this function.
Thursday, May 09
| 8:00PM - 11:00PM
Cash Bar
Room: Hall 6
Thursday, May 09
| 8:15PM - 11:00PM
Entertainment
Room: Hall 6
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Friday, May 10
| 10:24AM - 10:24AM
Departure
*Session Chair.
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