Past Meeting | Keystone Symposia

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	Intra- and Intercellular Mechanisms of Aging (2020B2)

Web Desc
Mitochondria in Aging and Age-Related Disease joint with Mitochondrial Biology in Heart and Skeletal Muscle Organizer(s): Gerald S. Shadel and Holly Van Remmen Date: January 13 - 17, 2019 Location: Keystone Resort, Keystone, CO, USA Sponsored by Astellas Pharma Inc. Summary of Meeting: Aging is the greatest risk factor for most human diseases, yet the underlying reasons for this are not clear and hence remain under intense investigation. Mitochondria have long been associated with aging as the cornerstones of the “mitochondrial” and “free radical” theories of aging. However, that the role of mitochondria in aging is simply due to declines in ATP production and increased oxidative stress via reactive oxygen species production is giving way to more complex hypotheses. These are driven by the realization that mitochondria are dynamic and have multiple additional roles in cell and organismal physiology (e.g., signaling and immunity). The goal of this conference is to bring together investigators working at the interface of mitochondria and aging to begin to develop network theories of mitochondrial contributions to aging and age-related diseases that take into account both “old” and “new” functions of mitochondria. Topics covered include neurodegeneration, cancer, metabolic diseases, inflammation and mitochondrial signaling pathways. It is expected that this conference will facilitate new interactions and collaborations at the interface of aging and mitochondrial biology. This should catalyze new research toward therapies for age-related diseases based on selectively targeting mitochondrial functions and signaling pathways in specific physiological and disease contexts. Scholarship Deadline: October 9 2018 Discounted Abstract Deadline: October 9 2018 Abstract Deadline: October 17 2018 Discounted Registration Deadline: November 14 2018 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Janssen R&D: Pharmaceutical Companies of Johnson & Johnson We gratefully acknowledge the generous grant for this conference provided by: National Institute on Aging (NIA) Grant No. 1R13AG060685-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Mitochondria in Aging and Age-Related Disease

joint with Mitochondrial Biology in Heart and Skeletal Muscle

Organizer(s): Gerald S. Shadel and Holly Van Remmen

Date: January 13 - 17, 2019
Location: Keystone Resort, Keystone, CO, USA

Program


Sunday, January 13 \| 4:00PM - 8:00PM Arrival and Registration Room: Longs Peak Foyer
Sunday, January 13 \| 6:00PM - 8:00PM Welcome Mixer Room: Longs Peak Foyer No registration fees are used to fund alcohol served at this function.
Monday, January 14 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Monday, January 14 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Grays/Longs Peak Speaker 1 of 7 * E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Monday, January 14 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Grays/Longs Peak Speaker 2 of 7 * Andrea L. Hevener, University of California, Los Angeles, USA
Monday, January 14 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Grays/Longs Peak Speaker 3 of 7 * Gerald S. Shadel, The Salk Institute for Biological Studies, USA
Monday, January 14 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Grays/Longs Peak Speaker 4 of 7 * Holly Van Remmen, Oklahoma Medical Research Foundation, USA
Monday, January 14 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Grays/Longs Peak Speaker 5 of 7 Andrew G. Dillin, University of California, Berkeley, USA Mitochondrial Regulation of Longevity
Monday, January 14 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Grays/Longs Peak Speaker 6 of 7 Vamsi K. Mootha, Massachusetts General Hospital, USA Hypoxia as a Therapy for Mitochondrial Disease
Monday, January 14 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Grays/Longs Peak Coffee Break
Monday, January 14 \| 9:50AM - 11:30AM Mitochondria in Cardiovascular Aging and Disease (Joint) Room: Grays/Longs Peak Speaker 1 of 6 * Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Monday, January 14 \| 9:50AM - 11:30AM Mitochondria in Cardiovascular Aging and Disease (Joint) Room: Grays/Longs Peak Speaker 2 of 6 * Kenneth M. Humphries, Oklahoma Medical Research Foundation, USA
Monday, January 14 \| 9:50AM - 11:30AM Mitochondria in Cardiovascular Aging and Disease (Joint) Room: Grays/Longs Peak Speaker 3 of 6 Hesham A. Sadek, University of Texas Southwestern Medical Center, USA Heart Regeneration via Inhibition of Aerobic Respiration
Monday, January 14 \| 9:50AM - 11:30AM Mitochondria in Cardiovascular Aging and Disease (Joint) Room: Grays/Longs Peak Speaker 4 of 6 Zoltan P. Arany, University of Pennsylvania, USA New Players in Mitophagy
Monday, January 14 \| 9:50AM - 11:30AM Mitochondria in Cardiovascular Aging and Disease (Joint) Room: Grays/Longs Peak Speaker 5 of 6 Timothy S. Luongo, University of Pennsylvania, USA Short Talk: Cardiac Nicotinamide Adenine Dinucleotide Depletion Results in Myocardial Dysfunction Despite Normal or Enhanced Mitochondrial Respiratory Capacity
Monday, January 14 \| 9:50AM - 11:30AM Mitochondria in Cardiovascular Aging and Disease (Joint) Room: Grays/Longs Peak Speaker 6 of 6 Pidder Jansen-Dürr, Universität Innsbruck, Austria Short Talk: Oxaloacetate Decarboxylase FAHD1 - A Novel Regulator of Mitochondrial Function and Cellular Senescence
Monday, January 14 \| 11:30AM - 5:00PM On Own for Lunch
Monday, January 14 \| 11:30AM - 1:00PM Poster Setup Room: Red Cloud/Shavano/Torreys
Monday, January 14 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano/Torreys
Monday, January 14 \| 2:30PM - 4:30PM Workshop This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 1 of 10 * Veronique Lacombe, Oklahoma State University, USA
Monday, January 14 \| 2:30PM - 4:30PM Workshop This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 2 of 10 * Katsu Funai, University of Utah, USA
Monday, January 14 \| 2:30PM - 4:30PM Workshop This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 3 of 10 Helena C. Kenny, University of Iowa, USA Inducible Deletion of OPA1 in the Heart Induces ER Stress that Precedes Mitochondrial and Contractile Dysfunction
Monday, January 14 \| 2:30PM - 4:30PM Workshop This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 4 of 10 Martin Picard, Columbia University, USA Human Mitochondrial 3D Network Organization and Nanotunnels in mtDNA Disease
Monday, January 14 \| 2:30PM - 4:30PM Workshop This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 5 of 10 Michael J. Jurczak, University of Pittsburgh, USA SGLT2 Inhibition Restores Mitochondrial Metabolic Flexibility in Heart and is Associated with Reduced Ischemia-Induced Cardiac Injury
Monday, January 14 \| 2:30PM - 4:30PM Workshop This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 6 of 10 Brad Willingham, NHLBI, National Institutes of Health, USA mitoRACE: In Vivo Assessment of Mitochondrial Function using Multiphoton NADH Fluorescence
Monday, January 14 \| 2:30PM - 4:30PM Workshop This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 7 of 10 Paul J. Wrighton, Brigham and Women's Hospital, USA Novel pH-Sensitive Biosensor Zebrafish Enable the in vivo Visualization and Interrogation of Mitophagy during Development and Metabolic Stress
Monday, January 14 \| 2:30PM - 4:30PM Workshop This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 8 of 10 Antonietta Franco, Washington University in St. Louis, USA Mfn-2 Shape Shifting Mutation Causes Cardiomyopathy
Monday, January 14 \| 2:30PM - 4:30PM Workshop This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 9 of 10 María Concepción Jiménez Gómez, National Center of Cardiovascular Research, Spain Development of OMA1 Inhibitor to Protect against Heart Failure in Mice
Monday, January 14 \| 2:30PM - 4:30PM Workshop This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 10 of 10 Jun Wang, Texas Heart Institute, USA Role of SUMO-2 in Cardiac Hypertrophy Induced by G Protein–Coupled Receptor Activation
Monday, January 14 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, January 14 \| 5:00PM - 7:00PM Mitochondrial Quality Control in Aging and Longevity Room: Grays Peak Speaker 1 of 6 * Liza A. Pon, Columbia University Medical Center, USA
Monday, January 14 \| 5:00PM - 7:00PM Mitochondrial Quality Control in Aging and Longevity Room: Grays Peak Speaker 2 of 6 Cole M. Haynes, University of Massachusetts Medical School, USA Mitochondrial UPR in Organismal Homeostasis and Aging
Monday, January 14 \| 5:00PM - 7:00PM Mitochondrial Quality Control in Aging and Longevity Room: Grays Peak Speaker 3 of 6 Richard J. Youle, NINDS, National Institutes of Health, USA Mitophagy and Inflammation during Exercise and Aging
Monday, January 14 \| 5:00PM - 7:00PM Mitochondrial Quality Control in Aging and Longevity Room: Grays Peak Speaker 4 of 6 Rong Li, Johns Hopkins University School of Medicine, USA Mitochondrial Degradation of Cytosolic Proteins by MAGIC
Monday, January 14 \| 5:00PM - 7:00PM Mitochondrial Quality Control in Aging and Longevity Room: Grays Peak Speaker 5 of 6 Shefali Krishna, The Salk Institute for Biological Studies, USA Short Talk: Long-Lived Proteins in the Mitochondria and their Role in Aging
Monday, January 14 \| 5:00PM - 7:00PM Mitochondrial Quality Control in Aging and Longevity Room: Grays Peak Speaker 6 of 6 Liam Coyne, SUNY Upstate Medical University, USA Short Talk: Mitochondrial Carrier Protein Overloading and Misfolding Induce Aggresomes in the Cytosol
Monday, January 14 \| 5:00PM - 7:00PM Skeletal Muscle Mitochondria and Metabolic Regulation This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 1 of 7 * P. Darrell Neufer, East Carolina University, USA
Monday, January 14 \| 5:00PM - 7:00PM Skeletal Muscle Mitochondria and Metabolic Regulation This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 2 of 7 * Yvan Ricardo Campos, St. Jude Children's Research Hospital, USA
Monday, January 14 \| 5:00PM - 7:00PM Skeletal Muscle Mitochondria and Metabolic Regulation This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 3 of 7 Anu Suomalainen Wartiovaara, University of Helsinki, Finland Mitochondrial Myopathies and FGF21
Monday, January 14 \| 5:00PM - 7:00PM Skeletal Muscle Mitochondria and Metabolic Regulation This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 4 of 7 Deborah M. Muoio, Duke University Medical Center, USA Mitochondrial Acetylation and Skeletal Muscle Metabolism
Monday, January 14 \| 5:00PM - 7:00PM Skeletal Muscle Mitochondria and Metabolic Regulation This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 5 of 7 K. Sreekumaran Nair, Mayo Clinic, USA Mitochondrial Protein Turnover and Metabolic Regulation
Monday, January 14 \| 5:00PM - 7:00PM Skeletal Muscle Mitochondria and Metabolic Regulation This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 6 of 7 Matthijs K. Hesselink, Maastricht University Medical Center, Netherlands Short Talk: Day-Night Rhythm in Mitochondrial Network Morphology in Human Skeletal Muscle
Monday, January 14 \| 5:00PM - 7:00PM Skeletal Muscle Mitochondria and Metabolic Regulation This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 7 of 7 Erik C. Böttger, University of Zurich, Switzerland Short Talk: Mitochondrial Misreading Accelerates Metabolic Aging in Skeletal Muscle
Monday, January 14 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Monday, January 14 \| 7:30PM - 10:00PM Poster Session 1 Room: Red Cloud/Shavano/Torreys
Tuesday, January 15 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Tuesday, January 15 \| 8:00AM - 11:00AM Mitochondria in Immunity and Inflammation Room: Grays Peak Speaker 1 of 8 * Gerald S. Shadel, The Salk Institute for Biological Studies, USA
Tuesday, January 15 \| 8:00AM - 11:00AM Mitochondria in Immunity and Inflammation Room: Grays Peak Speaker 2 of 8 Judith Campisi, Buck Institute for Research on Aging, USA Cellular Senescence, Mitochondrial Function and Aging
Tuesday, January 15 \| 8:00AM - 11:00AM Mitochondria in Immunity and Inflammation Room: Grays Peak Speaker 3 of 8 Anna Katharina Simon, University of Oxford, UK Autophagy, Mitochondria and Telomeres in Aged Lymphocytes
Tuesday, January 15 \| 8:00AM - 11:00AM Mitochondria in Immunity and Inflammation Room: Grays Peak Coffee Break
Tuesday, January 15 \| 8:00AM - 11:00AM Mitochondria in Immunity and Inflammation Room: Grays Peak Speaker 5 of 8 Michael Karin, University of California, San Diego, USA Mitochondrial DNA in Macrophage Immune Signaling
Tuesday, January 15 \| 8:00AM - 11:00AM Mitochondria in Immunity and Inflammation Room: Grays Peak Speaker 6 of 8 Peter D. Adams, Sanford Burnham Prebys Medical Discovery Institute, USA Short Talk: A Mitochondria-to-Nucleus Retrograde Signal Initiates Extrusion of Chromatin into Cytoplasm and Senescence-Associated Inflammation
Tuesday, January 15 \| 8:00AM - 11:00AM Mitochondria in Immunity and Inflammation Room: Grays Peak Speaker 7 of 8 Sweelin Chew, University of Eastern Finland, Finland Short Talk: Pinpointing Novel Targets of Air Pollution in Olfactory and Neural Cells
Tuesday, January 15 \| 8:00AM - 11:00AM Mitochondria in Immunity and Inflammation Room: Grays Peak Speaker 8 of 8 Adrienne Mottis, École Polytechnique Fédérale de Lausanne, Switzerland Short Talk: Doxycycline-Induced Mitochondrial Stress in Germ-Free Mice Reveals an Organ-Specific Response and Engages Antiviral Immunity
Tuesday, January 15 \| 8:00AM - 11:15AM Calcium Signaling in Muscle Mitochondria This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 1 of 10 * Paul S. Brookes, University of Rochester Medical Center, USA
Tuesday, January 15 \| 8:00AM - 11:15AM Calcium Signaling in Muscle Mitochondria This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 2 of 10 * Florin Despa, University of Kentucky, USA
Tuesday, January 15 \| 8:00AM - 11:15AM Calcium Signaling in Muscle Mitochondria This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 3 of 10 Anna Raffaello, University of Padova, Italy Role of Mitochondrial Calcium in the Maintenance of Skeletal Muscle Homeostasis
Tuesday, January 15 \| 8:00AM - 11:15AM Calcium Signaling in Muscle Mitochondria This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 4 of 10 György Hajnóczky, Thomas Jefferson University, USA Mitochondrial Dynamics and Excitation Contraction Coupling
Tuesday, January 15 \| 8:00AM - 11:15AM Calcium Signaling in Muscle Mitochondria This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Coffee Break
Tuesday, January 15 \| 8:00AM - 11:15AM Calcium Signaling in Muscle Mitochondria This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 6 of 10 Toren Finkel, University of Pittsburgh, UPMC, USA Mitochondrial Calcium Uptake Mechanisms in the Heart
Tuesday, January 15 \| 8:00AM - 11:15AM Calcium Signaling in Muscle Mitochondria This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 7 of 10 Stefan Feske, New York University School of Medicine, USA Store Operated Calcium and Mitochondrial Metabolism
Tuesday, January 15 \| 8:00AM - 11:15AM Calcium Signaling in Muscle Mitochondria This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 8 of 10 Denis Vecellio Reane, University of Padova, Italy Short Talk: A MICU1 Splice Variant Confers High Sensitivity to the Ca2+ Uptake Machinery of Skeletal Muscle
Tuesday, January 15 \| 8:00AM - 11:15AM Calcium Signaling in Muscle Mitochondria This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 9 of 10 Olha Koval, University of Iowa, USA Short Talk: Mitochondrial Ca2+ Uptake via MCU Controls Cell Proliferation through CaMKII and Drp-1
Tuesday, January 15 \| 8:00AM - 11:15AM Calcium Signaling in Muscle Mitochondria This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 10 of 10 Luiz H. M. Bozi, University of São Paulo, Brazil Short Talk: Inhibition of Mitochondrial Unfolded Protein Response (mtUPR) Mediates Doxorubicin-Induced Cardiotoxicity
Tuesday, January 15 \| 11:00AM - 5:00PM On Own for Lunch
Tuesday, January 15 \| 11:00AM - 1:00PM Poster Setup Room: Red Cloud/Shavano/Torreys
Tuesday, January 15 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano/Torreys
Tuesday, January 15 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, January 15 \| 5:00PM - 7:00PM Mitochondrial Metabolism in Aging Room: Grays Peak Speaker 1 of 6 * Holly Van Remmen, Oklahoma Medical Research Foundation, USA
Tuesday, January 15 \| 5:00PM - 7:00PM Mitochondrial Metabolism in Aging Room: Grays Peak Speaker 2 of 6 Noga Ron-Harel, Technion-Israel Institute of Technology, Israel Mitochondrial Metabolism in T Cell Activation and Aging
Tuesday, January 15 \| 5:00PM - 7:00PM Mitochondrial Metabolism in Aging Room: Grays Peak Speaker 3 of 6 Matthew D. Hirschey, Duke University, USA Sirtuins Control Mitochondrial Metabolism and Aging
Tuesday, January 15 \| 5:00PM - 7:00PM Mitochondrial Metabolism in Aging Room: Grays Peak Speaker 4 of 6 Hazel H. Szeto, Social Profit Network Research Laboratory, USA Cardiolipin-Targeted Peptides Rejuvenate Mitochondrial Function, Remodel Mitochondria, and Promote Tissue Regeneration during Aging
Tuesday, January 15 \| 5:00PM - 7:00PM Mitochondrial Metabolism in Aging Room: Grays Peak Speaker 5 of 6 Adam L. Hughes, University of Utah, USA Short Talk: Dissecting the Metabolic Connection Between Mitochondria and Lysosomes in Aging
Tuesday, January 15 \| 5:00PM - 7:00PM Mitochondrial Metabolism in Aging Room: Grays Peak Speaker 6 of 6 Jennifer Baily, University of California, Davis, USA Short Talk: Alternating Phases of AMPK and mTORC1: A Potential Mechanism of Mitochondrial Biogenesis during Electron Transport Chain Inhibition
Tuesday, January 15 \| 5:00PM - 7:00PM Novel Regulators of Mitochondrial Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 1 of 7 * Liming Pei, Children's Hospital of Philadelphia/University of Pennsylvania, USA
Tuesday, January 15 \| 5:00PM - 7:00PM Novel Regulators of Mitochondrial Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 2 of 7 * Ryan L. Boudreau, University of Iowa, USA
Tuesday, January 15 \| 5:00PM - 7:00PM Novel Regulators of Mitochondrial Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 3 of 7 Andrea L. Hevener, University of California, Los Angeles, USA Estrogen Regulation of Skeletal Muscle Mitochondria and Insulin Sensitivity
Tuesday, January 15 \| 5:00PM - 7:00PM Novel Regulators of Mitochondrial Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 4 of 7 Daniel P. Kelly, University of Pennsylvania, USA Cardiac Mitochondrial Remodeling in Health and Disease
Tuesday, January 15 \| 5:00PM - 7:00PM Novel Regulators of Mitochondrial Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 5 of 7 Karyn A. Esser, University of Florida, USA Circadian Regulation of Skeletal Muscle Mitochondrial Metabolism
Tuesday, January 15 \| 5:00PM - 7:00PM Novel Regulators of Mitochondrial Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 6 of 7 Weiwei Fan, The Salk Institute for Biological Studies, USA Short Talk: Estrogen-Related Receptors a and ? are Master Regulators of Innate and Adaptive Mitochondrial Energy Metabolism in Muscle
Tuesday, January 15 \| 5:00PM - 7:00PM Novel Regulators of Mitochondrial Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 7 of 7 Julien Delezie, University of Basel, Switzerland Short Talk: PER2 is a Potent Regulator of Mitochondrial Function in Mouse Skeletal Muscle
Tuesday, January 15 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Tuesday, January 15 \| 7:30PM - 10:00PM Poster Session 2 Room: Red Cloud/Shavano/Torreys
Wednesday, January 16 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Wednesday, January 16 \| 8:00AM - 11:00AM Mitochondrial Signaling in Aging Room: Grays Peak Speaker 1 of 8 * Carlos T. Moraes, University of Miami, USA
Wednesday, January 16 \| 8:00AM - 11:00AM Mitochondrial Signaling in Aging Room: Grays Peak Speaker 2 of 8 Navdeep S. Chandel, Northwestern University, USA Mitochondria as Signaling Organelles
Wednesday, January 16 \| 8:00AM - 11:00AM Mitochondrial Signaling in Aging Room: Grays Peak Speaker 3 of 8 Tamas L. Horvath, Yale School of Medicine, USA Hypothalamic Mitochondrial Dynamics in Homeostatic Control and Aging
Wednesday, January 16 \| 8:00AM - 11:00AM Mitochondrial Signaling in Aging Room: Grays Peak Coffee Break
Wednesday, January 16 \| 8:00AM - 11:00AM Mitochondrial Signaling in Aging Room: Grays Peak Speaker 5 of 8 Gerald S. Shadel, The Salk Institute for Biological Studies, USA Adaptive, Anti-Aging Responses to Mitochondrial Stress: From Yeast to Mammals
Wednesday, January 16 \| 8:00AM - 11:00AM Mitochondrial Signaling in Aging Room: Grays Peak Speaker 6 of 8 Jose M. Cuezva, Universidad Autónoma de Madrid, Spain ATPase Inhibitory Factor 1 (IF1), a Driver of Mitochondrial/Nuclear Genome Signaling Pathways
Wednesday, January 16 \| 8:00AM - 11:00AM Mitochondrial Signaling in Aging Room: Grays Peak Speaker 7 of 8 Gavin Pharaoh, University of Oklahoma Health Sciences Center, USA Short Talk: Central and Peripheral Effects of IGF-1 Deficiency on Tissue Mitochondrial Function
Wednesday, January 16 \| 8:00AM - 11:00AM Mitochondrial Signaling in Aging Room: Grays Peak Speaker 8 of 8 Robert Radford, The Salk Institute for Biological Studies, USA Short Talk: TIN2: A Mitochondrial Effector of Telomere Status in Aging
Wednesday, January 16 \| 8:00AM - 11:15AM Mitochondria and Cell Death This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 1 of 9 * Anton M. Bennett, Yale University School Of Medicine, USA
Wednesday, January 16 \| 8:00AM - 11:15AM Mitochondria and Cell Death This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 2 of 9 Junichi Sadoshima, Rutgers New Jersey Medical School, USA Autophagy and Mitochondrial Dysfunction in Heart Failure
Wednesday, January 16 \| 8:00AM - 11:15AM Mitochondria and Cell Death This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 3 of 9 Åsa B. Gustafsson, University of California, San Diego, USA Beclin1 as a Key Regulator of Mitochondrial Quality Control
Wednesday, January 16 \| 8:00AM - 11:15AM Mitochondria and Cell Death This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Coffee Break
Wednesday, January 16 \| 8:00AM - 11:15AM Mitochondria and Cell Death This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 5 of 9 Gerald W. Dorn, II, Washington University School of Medicine, USA Cardiomitopathy – Novel Cardiomyopathy of Dysfunctional Mitochondria
Wednesday, January 16 \| 8:00AM - 11:15AM Mitochondria and Cell Death This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 6 of 9 Hiromi Sesaki, Johns Hopkins University School of Medicine, USA Mitochondrial Dynamics and Mitophagy
Wednesday, January 16 \| 8:00AM - 11:15AM Mitochondria and Cell Death This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 7 of 9 Juyoun Beak, University of North Carolina, USA Short Talk: The Nuclear Receptor RORa Plays Critical Roles in Mitochondrial Quality Control
Wednesday, January 16 \| 8:00AM - 11:15AM Mitochondria and Cell Death This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 8 of 9 Payam Anthony Gammage, University of Cambridge, UK Short Talk: Genome Editing in Cardiac Mitochondria Corrects a Pathogenic mtDNA Mutation in vivo
Wednesday, January 16 \| 8:00AM - 11:15AM Mitochondria and Cell Death This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 9 of 9 * Joan M. Taylor, University of North Carolina at Chapel Hill, USA Short Talk: GRAF1 is A Novel Mediator of Parkin-Dependent Mitophagy
Wednesday, January 16 \| 11:00AM - 5:00PM On Own for Lunch
Wednesday, January 16 \| 11:00AM - 1:00PM Poster Setup Room: Red Cloud/Shavano/Torreys
Wednesday, January 16 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano/Torreys
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop: Mitochondrial Metabolic Signaling and Communicatio n with Other Organelles in Aging Room: Grays Peak Speaker 1 of 9 * Dan Gottschling, Calico, USA
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop: Mitochondrial Metabolic Signaling and Communicatio n with Other Organelles in Aging Room: Grays Peak Speaker 2 of 9 Sam Katz, Yale University School of Medicine, USA Regulation of ER-Mitochondrial Contact Site Signaling by the BCL-2 Family Member BOK
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop: Mitochondrial Metabolic Signaling and Communicatio n with Other Organelles in Aging Room: Grays Peak Speaker 3 of 9 Changhan Lee, University of Southern California and Ajou University, USA Intergenomic Basis of Mitonuclear Communication
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop: Mitochondrial Metabolic Signaling and Communicatio n with Other Organelles in Aging Room: Grays Peak Speaker 4 of 9 Nuno Raimundo, University Medical Center Goettingen, Germany Impact of Mitochondrial Function in Aging Is Mediated by Impaired Lysosomes
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop: Mitochondrial Metabolic Signaling and Communicatio n with Other Organelles in Aging Room: Grays Peak Speaker 5 of 9 Katharina Schlacher, MD Anderson Cancer Center, USA Mitochondrial DNA Replication Fork Stability by the BRCA/Fanconi Anemia Pathway Suppresses Inflammation and Disease
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop: Mitochondrial Metabolic Signaling and Communicatio n with Other Organelles in Aging Room: Grays Peak Speaker 6 of 9 Jaroslaw Waldemar Zmijewski, University of Alabama, USA AMPK is a Therapeutic Target for Metabolic and Bioenergetic Maladaptation in Aging-Related Non-Resolving Lung Fibrosis
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop: Mitochondrial Metabolic Signaling and Communicatio n with Other Organelles in Aging Room: Grays Peak Speaker 7 of 9 Ana Victoria Lechuga Vieco, Spanish National Center for Cardiovascular Research, Spain Mitochondrial and Nuclear DNA Matching Shapes Metabolism and Healthy Ageing
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop: Mitochondrial Metabolic Signaling and Communicatio n with Other Organelles in Aging Room: Grays Peak Speaker 8 of 9 Kortessa Sotiropoulou, Institute of Medical Biology, ASTAR, Singapore The Proline Metabolic Pathway in Human Skin Ageing
Wednesday, January 16 \| 2:30PM - 4:30PM Workshop: Mitochondrial Metabolic Signaling and Communicatio n with Other Organelles in Aging Room: Grays Peak Speaker 9 of 9 Teresa Gonçalves, University of Coimbra, Portugal Dynamics of Adenosine A2A Receptors is Associated with Increased Susceptibility to Candida Albicans Colonization and Inflammation in the Elderly
Wednesday, January 16 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, January 16 \| 5:00PM - 7:00PM Mitochondrial Dynamics and Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 1 of 7 * John P. Kirwan, Pennington Biomedical Research Center, USA
Wednesday, January 16 \| 5:00PM - 7:00PM Mitochondrial Dynamics and Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 2 of 7 * Brian Timothy O'Neill, University of Iowa, Carver College of Medicine, USA
Wednesday, January 16 \| 5:00PM - 7:00PM Mitochondrial Dynamics and Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 3 of 7 E. Dale Abel, University of Iowa, Carver College of Medicine, USA Paracrine Regulation of Metabolism by OPA1
Wednesday, January 16 \| 5:00PM - 7:00PM Mitochondrial Dynamics and Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 4 of 7 Robert S. Balaban, NHLBI, National Institutes of Health, USA The Mitochondria Reticulum of Muscle Cells
Wednesday, January 16 \| 5:00PM - 7:00PM Mitochondrial Dynamics and Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 5 of 7 Antonio Zorzano, Institute for Research in Biomedicine, Spain Mitochondrial Fusion Proteins, Metabolism and Inflammation
Wednesday, January 16 \| 5:00PM - 7:00PM Mitochondrial Dynamics and Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 6 of 7 Brian Glancy, NHLBI and NIAMS, National Institutes of Health, USA Short Talk: Intra- and Inter-Organelle Interactions within the Muscle Mitochondrial Reticulum
Wednesday, January 16 \| 5:00PM - 7:00PM Mitochondrial Dynamics and Metabolism This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 7 of 7 Sandra S. Zinkel, Vanderbilt University, USA Short Talk: Bid Maintains Mitochondrial Cristae Structure and Function and Protects against Cardiac Disease in an Integrative Genomics Study
Wednesday, January 16 \| 5:00PM - 7:00PM Mitochondria in Age-Related Pathology Room: Grays Peak Speaker 1 of 5 * Rudolf J. Wiesner, University of Cologne, Germany
Wednesday, January 16 \| 5:00PM - 7:00PM Mitochondria in Age-Related Pathology Room: Grays Peak Speaker 2 of 5 David J. Marcinek, University of Washington, USA The Effects of Mitochondrial Redox Stress on Energetics and the Proteome in Aged Skeletal Muscle
Wednesday, January 16 \| 5:00PM - 7:00PM Mitochondria in Age-Related Pathology Room: Grays Peak Speaker 3 of 5 Scott M. Plafker, Oklahoma Medical Research Foundation, USA Mitochondria-Associated Stress Sensing Proteins Govern Intracellular Homeostasis
Wednesday, January 16 \| 5:00PM - 7:00PM Mitochondria in Age-Related Pathology Room: Grays Peak Speaker 4 of 5 James B. Stewart, Max Planck Institute for Biology of Ageing, Germany Mouse Models of Mitochondrial DNA Mutations in Disease Pathology
Wednesday, January 16 \| 5:00PM - 7:00PM Mitochondria in Age-Related Pathology Room: Grays Peak Speaker 5 of 5 Douglas C. Wallace, Children's Hospital of Philadelphia, USA Nuclear-Mitochondrial Interactions in Age-Related Diseases
Wednesday, January 16 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Wednesday, January 16 \| 7:30PM - 10:00PM Poster Session 3 Room: Red Cloud/Shavano/Torreys
Thursday, January 17 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Thursday, January 17 \| 8:00AM - 11:00AM Mitochondria in Aging Muscle (Joint) Room: Grays/Longs Peak Speaker 1 of 8 * In-Kyu Lee, Kyungpook National University Hospital, South Korea
Thursday, January 17 \| 8:00AM - 11:00AM Mitochondria in Aging Muscle (Joint) Room: Grays/Longs Peak Speaker 2 of 8 David J. Glass, Regeneron Pharmaceuticals, Inc., USA Mitochondria Pathways in Aging and Sarcopenia
Thursday, January 17 \| 8:00AM - 11:00AM Mitochondria in Aging Muscle (Joint) Room: Grays/Longs Peak Coffee Break
Thursday, January 17 \| 8:00AM - 11:00AM Mitochondria in Aging Muscle (Joint) Room: Grays/Longs Peak Speaker 4 of 8 Holly Van Remmen, Oklahoma Medical Research Foundation, USA Is Mitochondrial Oxidative Stress a Determining Factor in Sarcopenia?
Thursday, January 17 \| 8:00AM - 11:00AM Mitochondria in Aging Muscle (Joint) Room: Grays/Longs Peak Speaker 5 of 8 Mike P. Murphy, Medical Research Council, UK Therapeutic Targeting of Mitochondria
Thursday, January 17 \| 8:00AM - 11:00AM Mitochondria in Aging Muscle (Joint) Room: Grays/Longs Peak Speaker 6 of 8 Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland New Insights into the Genetics of Mitochondria and Aging
Thursday, January 17 \| 8:00AM - 11:00AM Mitochondria in Aging Muscle (Joint) Room: Grays/Longs Peak Speaker 7 of 8 Mitchell Allen, Virginia Tech, USA Short Talk: The Cardiolipin-Aggregating Peptide Elamipretide Protects Mitochondrial Structure-Function
Thursday, January 17 \| 8:00AM - 11:00AM Mitochondria in Aging Muscle (Joint) Room: Grays/Longs Peak Speaker 8 of 8 Robert V. Musci, Colorado State University, USA Short Talk: Nrf2 Activator Improves Mitochondrial Function and Attenuates Age-Related Musculoskeletal Dysfunction in a Novel Guinea Pig Model
Thursday, January 17 \| 11:00AM - 5:00PM On Own for Lunch
Thursday, January 17 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, January 17 \| 5:00PM - 6:45PM Mitochondria Dynamics and Aging Room: Grays Peak Speaker 1 of 5 * Richard J. Youle, NINDS, National Institutes of Health, USA
Thursday, January 17 \| 5:00PM - 6:45PM Mitochondria Dynamics and Aging Room: Grays Peak Speaker 2 of 5 Liza A. Pon, Columbia University Medical Center, USA Inheritance of the Fittest Mitochondria and Lifespan Control in Budding Yeast
Thursday, January 17 \| 5:00PM - 6:45PM Mitochondria Dynamics and Aging Room: Grays Peak Speaker 3 of 5 Monica Driscoll, Rutgers University, USA Throwing It Away: Neuronal Extrusion of Trashy Mitochondria as a Mito-Stasis Strategy
Thursday, January 17 \| 5:00PM - 6:45PM Mitochondria Dynamics and Aging Room: Grays Peak Speaker 4 of 5 Lisa Norquay, Janssen, USA Mitochondrial Dynamics and Mitophagy in Metabolic Disease
Thursday, January 17 \| 5:00PM - 6:45PM Mitochondria Dynamics and Aging Room: Grays Peak Speaker 5 of 5 Sofie Hindkjaer Lautrup, University of Oslo and Akershus University Hospital, Norway Short Talk: NAD+ Prevents Accelerated Aging in Werner Syndrome by Induction of Mitophagy
Thursday, January 17 \| 5:00PM - 7:00PM Mitochondria, Energy Expenditure and Insulin Sensitivity This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 1 of 7 * Anastasia Kralli, Johns Hopkins Medical School, USA
Thursday, January 17 \| 5:00PM - 7:00PM Mitochondria, Energy Expenditure and Insulin Sensitivity This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 2 of 7 * Weiwei Fan, The Salk Institute for Biological Studies, USA
Thursday, January 17 \| 5:00PM - 7:00PM Mitochondria, Energy Expenditure and Insulin Sensitivity This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 3 of 7 Patrick Schrauwen, Maastricht University, Netherlands Human Skeletal Muscle Mitochondrial function and Insulin Sensitivity
Thursday, January 17 \| 5:00PM - 7:00PM Mitochondria, Energy Expenditure and Insulin Sensitivity This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 4 of 7 Mary-Ellen Harper, University of Ottawa, Canada Skeletal Muscle Mitochondrial Energetics in Diet-Resistant and Diet-Sensitive Obesity
Thursday, January 17 \| 5:00PM - 7:00PM Mitochondria, Energy Expenditure and Insulin Sensitivity This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 5 of 7 Francesca Amati, University of Lausanne, Switzerland Mitochondria and Substrate Switches
Thursday, January 17 \| 5:00PM - 7:00PM Mitochondria, Energy Expenditure and Insulin Sensitivity This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 6 of 7 Yvan Ricardo Campos, St. Jude Children's Research Hospital, USA Short Talk: Mitochondrial Defects in Ozz and Alix Knockout Mouse Models
Thursday, January 17 \| 5:00PM - 7:00PM Mitochondria, Energy Expenditure and Insulin Sensitivity This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak Speaker 7 of 7 Danielle S. Murashige, University of Pennsylvania, USA Short Talk: Promotion of Specifically Cardiac Branched Chain Amino Acid Metabolism does not Prevent Cardiac Remodeling
Thursday, January 17 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Grays Peak
Thursday, January 17 \| 7:00PM - 7:15PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) This session is from Mito, Heart & Skeletal Muscle Room: Longs Peak
Thursday, January 17 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Thursday, January 17 \| 8:00PM - 11:00PM Entertainment Room: Red Cloud/Shavano/Torreys Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, January 17 \| 8:00PM - 11:00PM Cash Bar Room: Red Cloud/Shavano/Torreys
Friday, January 18 \| 10:24AM - 10:24AM Departure *Session Chair.