Web Desc
Mitochondria in Aging and Age-Related Disease
joint with Mitochondrial Biology in Heart and Skeletal Muscle
Organizer(s): Gerald S. Shadel and Holly Van Remmen
Date: January 13 - 17, 2019
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Astellas Pharma Inc.
Summary of Meeting:
Aging is the greatest risk factor for most human diseases, yet the underlying reasons for this are not clear and hence remain under intense investigation. Mitochondria have long been associated with aging as the cornerstones of the “mitochondrial” and “free radical” theories of aging. However, that the role of mitochondria in aging is simply due to declines in ATP production and increased oxidative stress via reactive oxygen species production is giving way to more complex hypotheses. These are driven by the realization that mitochondria are dynamic and have multiple additional roles in cell and organismal physiology (e.g., signaling and immunity). The goal of this conference is to bring together investigators working at the interface of mitochondria and aging to begin to develop network theories of mitochondrial contributions to aging and age-related diseases that take into account both “old” and “new” functions of mitochondria. Topics covered include neurodegeneration, cancer, metabolic diseases, inflammation and mitochondrial signaling pathways. It is expected that this conference will facilitate new interactions and collaborations at the interface of aging and mitochondrial biology. This should catalyze new research toward therapies for age-related diseases based on selectively targeting mitochondrial functions and signaling pathways in specific physiological and disease contexts.
Scholarship Deadline: October 9 2018
Discounted Abstract Deadline: October 9 2018
Abstract Deadline: October 17 2018
Discounted Registration Deadline: November 14 2018
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Astellas Pharma Inc.
We gratefully acknowledge additional support for this conference from:
Aging Cell
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Janssen R&D: Pharmaceutical Companies of Johnson & Johnson
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1R13AG060685-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 13 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, January 13 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Monday, January 14 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 1 of 7
* E. Dale Abel, University of Iowa, Carver College of Medicine, USA

Monday, January 14 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 2 of 7
* Andrea L. Hevener, University of California, Los Angeles, USA

Monday, January 14 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 3 of 7
* Gerald S. Shadel, The Salk Institute for Biological Studies, USA

Monday, January 14 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 4 of 7
* Holly Van Remmen, Oklahoma Medical Research Foundation, USA

Monday, January 14 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 5 of 7
Andrew G. Dillin, University of California, Berkeley, USA
Mitochondrial Regulation of Longevity

Monday, January 14 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 6 of 7
Vamsi K. Mootha, Massachusetts General Hospital, USA
Hypoxia as a Therapy for Mitochondrial Disease

Monday, January 14 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Grays/Longs Peak


Coffee Break

Monday, January 14 | 9:50AM - 11:30AM
Mitochondria in Cardiovascular Aging and Disease (Joint)
Room: Grays/Longs Peak

Speaker 1 of 6
* Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA

Monday, January 14 | 9:50AM - 11:30AM
Mitochondria in Cardiovascular Aging and Disease (Joint)
Room: Grays/Longs Peak

Speaker 2 of 6
* Kenneth M. Humphries, Oklahoma Medical Research Foundation, USA

Monday, January 14 | 9:50AM - 11:30AM
Mitochondria in Cardiovascular Aging and Disease (Joint)
Room: Grays/Longs Peak

Speaker 3 of 6
Hesham A. Sadek, University of Texas Southwestern Medical Center, USA
Heart Regeneration via Inhibition of Aerobic Respiration

Monday, January 14 | 9:50AM - 11:30AM
Mitochondria in Cardiovascular Aging and Disease (Joint)
Room: Grays/Longs Peak

Speaker 4 of 6
Zoltan P. Arany, University of Pennsylvania, USA
New Players in Mitophagy

Monday, January 14 | 9:50AM - 11:30AM
Mitochondria in Cardiovascular Aging and Disease (Joint)
Room: Grays/Longs Peak

Speaker 5 of 6
Timothy S. Luongo, University of Pennsylvania, USA
Short Talk: Cardiac Nicotinamide Adenine Dinucleotide Depletion Results in Myocardial Dysfunction Despite Normal or
Enhanced Mitochondrial Respiratory Capacity


Monday, January 14 | 9:50AM - 11:30AM
Mitochondria in Cardiovascular Aging and Disease (Joint)
Room: Grays/Longs Peak

Speaker 6 of 6
Pidder Jansen-Dürr, Universität Innsbruck, Austria
Short Talk: Oxaloacetate Decarboxylase FAHD1 - A Novel Regulator of Mitochondrial Function and Cellular Senescence

Monday, January 14 | 11:30AM - 5:00PM
On Own for Lunch


Monday, January 14 | 11:30AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Monday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Monday, January 14 | 2:30PM - 4:30PM
Workshop
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 1 of 10
* Veronique Lacombe, Oklahoma State University, USA


Monday, January 14 | 2:30PM - 4:30PM
Workshop
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 2 of 10
* Katsu Funai, University of Utah, USA


Monday, January 14 | 2:30PM - 4:30PM
Workshop
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 3 of 10
Helena C. Kenny, University of Iowa, USA
Inducible Deletion of OPA1 in the Heart Induces ER Stress that Precedes Mitochondrial and Contractile Dysfunction


Monday, January 14 | 2:30PM - 4:30PM
Workshop
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 4 of 10
Martin Picard, Columbia University, USA
Human Mitochondrial 3D Network Organization and Nanotunnels in mtDNA Disease


Monday, January 14 | 2:30PM - 4:30PM
Workshop
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 5 of 10
Michael J. Jurczak, University of Pittsburgh, USA
SGLT2 Inhibition Restores Mitochondrial Metabolic Flexibility in Heart and is Associated with Reduced Ischemia-Induced Cardiac Injury


Monday, January 14 | 2:30PM - 4:30PM
Workshop
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 6 of 10
Brad Willingham, NHLBI, National Institutes of Health, USA
mitoRACE: In Vivo Assessment of Mitochondrial Function using Multiphoton NADH Fluorescence


Monday, January 14 | 2:30PM - 4:30PM
Workshop
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 7 of 10
Paul J. Wrighton, Brigham and Women's Hospital, USA
Novel pH-Sensitive Biosensor Zebrafish Enable the in vivo Visualization and Interrogation of Mitophagy during Development and Metabolic Stress


Monday, January 14 | 2:30PM - 4:30PM
Workshop
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 8 of 10
Antonietta Franco, Washington University in St. Louis, USA
Mfn-2 Shape Shifting Mutation Causes Cardiomyopathy


Monday, January 14 | 2:30PM - 4:30PM
Workshop
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 9 of 10
María Concepción Jiménez Gómez, National Center of Cardiovascular Research, Spain
Development of OMA1 Inhibitor to Protect against Heart Failure in Mice


Monday, January 14 | 2:30PM - 4:30PM
Workshop
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 10 of 10
Jun Wang, Texas Heart Institute, USA
Role of SUMO-2 in Cardiac Hypertrophy Induced by G Protein–Coupled Receptor Activation


Monday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 14 | 5:00PM - 7:00PM
Mitochondrial Quality Control in Aging and Longevity
Room: Grays Peak

Speaker 1 of 6
* Liza A. Pon, Columbia University Medical Center, USA

Monday, January 14 | 5:00PM - 7:00PM
Mitochondrial Quality Control in Aging and Longevity
Room: Grays Peak

Speaker 2 of 6
Cole M. Haynes, University of Massachusetts Medical School, USA
Mitochondrial UPR in Organismal Homeostasis and Aging

Monday, January 14 | 5:00PM - 7:00PM
Mitochondrial Quality Control in Aging and Longevity
Room: Grays Peak

Speaker 3 of 6
Richard J. Youle, NINDS, National Institutes of Health, USA
Mitophagy and Inflammation during Exercise and Aging

Monday, January 14 | 5:00PM - 7:00PM
Mitochondrial Quality Control in Aging and Longevity
Room: Grays Peak

Speaker 4 of 6
Rong Li, Johns Hopkins University School of Medicine, USA
Mitochondrial Degradation of Cytosolic Proteins by MAGIC

Monday, January 14 | 5:00PM - 7:00PM
Mitochondrial Quality Control in Aging and Longevity
Room: Grays Peak

Speaker 5 of 6
Shefali Krishna, The Salk Institute for Biological Studies, USA
Short Talk: Long-Lived Proteins in the Mitochondria and their Role in Aging

Monday, January 14 | 5:00PM - 7:00PM
Mitochondrial Quality Control in Aging and Longevity
Room: Grays Peak

Speaker 6 of 6
Liam Coyne, SUNY Upstate Medical University, USA
Short Talk: Mitochondrial Carrier Protein Overloading and Misfolding Induce Aggresomes in the Cytosol

Monday, January 14 | 5:00PM - 7:00PM
Skeletal Muscle Mitochondria and Metabolic Regulation
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 1 of 7
* P. Darrell Neufer, East Carolina University, USA


Monday, January 14 | 5:00PM - 7:00PM
Skeletal Muscle Mitochondria and Metabolic Regulation
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 2 of 7
* Yvan Ricardo Campos, St. Jude Children's Research Hospital, USA


Monday, January 14 | 5:00PM - 7:00PM
Skeletal Muscle Mitochondria and Metabolic Regulation
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 3 of 7
Anu Suomalainen Wartiovaara, University of Helsinki, Finland
Mitochondrial Myopathies and FGF21


Monday, January 14 | 5:00PM - 7:00PM
Skeletal Muscle Mitochondria and Metabolic Regulation
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 4 of 7
Deborah M. Muoio, Duke University Medical Center, USA
Mitochondrial Acetylation and Skeletal Muscle Metabolism


Monday, January 14 | 5:00PM - 7:00PM
Skeletal Muscle Mitochondria and Metabolic Regulation
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 5 of 7
K. Sreekumaran Nair, Mayo Clinic, USA
Mitochondrial Protein Turnover and Metabolic Regulation


Monday, January 14 | 5:00PM - 7:00PM
Skeletal Muscle Mitochondria and Metabolic Regulation
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 6 of 7
Matthijs K. Hesselink, Maastricht University Medical Center, Netherlands
Short Talk: Day-Night Rhythm in Mitochondrial Network Morphology in Human Skeletal Muscle


Monday, January 14 | 5:00PM - 7:00PM
Skeletal Muscle Mitochondria and Metabolic Regulation
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 7 of 7
Erik C. Böttger, University of Zurich, Switzerland
Short Talk: Mitochondrial Misreading Accelerates Metabolic Aging in Skeletal Muscle


Monday, January 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Monday, January 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Red Cloud/Shavano/Torreys


Tuesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Tuesday, January 15 | 8:00AM - 11:00AM
Mitochondria in Immunity and Inflammation
Room: Grays Peak

Speaker 1 of 8
* Gerald S. Shadel, The Salk Institute for Biological Studies, USA

Tuesday, January 15 | 8:00AM - 11:00AM
Mitochondria in Immunity and Inflammation
Room: Grays Peak

Speaker 2 of 8
Judith Campisi, Buck Institute for Research on Aging, USA
Cellular Senescence, Mitochondrial Function and Aging

Tuesday, January 15 | 8:00AM - 11:00AM
Mitochondria in Immunity and Inflammation
Room: Grays Peak

Speaker 3 of 8
Anna Katharina Simon, University of Oxford, UK
Autophagy, Mitochondria and Telomeres in Aged Lymphocytes

Tuesday, January 15 | 8:00AM - 11:00AM
Mitochondria in Immunity and Inflammation
Room: Grays Peak


Coffee Break

Tuesday, January 15 | 8:00AM - 11:00AM
Mitochondria in Immunity and Inflammation
Room: Grays Peak

Speaker 5 of 8
Michael Karin, University of California, San Diego, USA
Mitochondrial DNA in Macrophage Immune Signaling

Tuesday, January 15 | 8:00AM - 11:00AM
Mitochondria in Immunity and Inflammation
Room: Grays Peak

Speaker 6 of 8
Peter D. Adams, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: A Mitochondria-to-Nucleus Retrograde Signal Initiates Extrusion of Chromatin into Cytoplasm and Senescence-Associated Inflammation

Tuesday, January 15 | 8:00AM - 11:00AM
Mitochondria in Immunity and Inflammation
Room: Grays Peak

Speaker 7 of 8
Sweelin Chew, University of Eastern Finland, Finland
Short Talk: Pinpointing Novel Targets of Air Pollution in Olfactory and Neural Cells

Tuesday, January 15 | 8:00AM - 11:00AM
Mitochondria in Immunity and Inflammation
Room: Grays Peak

Speaker 8 of 8
Adrienne Mottis, École Polytechnique Fédérale de Lausanne, Switzerland
Short Talk: Doxycycline-Induced Mitochondrial Stress in Germ-Free Mice Reveals an Organ-Specific Response and Engages Antiviral Immunity

Tuesday, January 15 | 8:00AM - 11:15AM
Calcium Signaling in Muscle Mitochondria
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 1 of 10
* Paul S. Brookes, University of Rochester Medical Center, USA


Tuesday, January 15 | 8:00AM - 11:15AM
Calcium Signaling in Muscle Mitochondria
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 2 of 10
* Florin Despa, University of Kentucky, USA


Tuesday, January 15 | 8:00AM - 11:15AM
Calcium Signaling in Muscle Mitochondria
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 3 of 10
Anna Raffaello, University of Padova, Italy
Role of Mitochondrial Calcium in the Maintenance of Skeletal Muscle Homeostasis


Tuesday, January 15 | 8:00AM - 11:15AM
Calcium Signaling in Muscle Mitochondria
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 4 of 10
György Hajnóczky, Thomas Jefferson University, USA
Mitochondrial Dynamics and Excitation Contraction Coupling


Tuesday, January 15 | 8:00AM - 11:15AM
Calcium Signaling in Muscle Mitochondria
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak


Coffee Break


Tuesday, January 15 | 8:00AM - 11:15AM
Calcium Signaling in Muscle Mitochondria
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 6 of 10
Toren Finkel, University of Pittsburgh, UPMC, USA
Mitochondrial Calcium Uptake Mechanisms in the Heart


Tuesday, January 15 | 8:00AM - 11:15AM
Calcium Signaling in Muscle Mitochondria
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 7 of 10
Stefan Feske, New York University School of Medicine, USA
Store Operated Calcium and Mitochondrial Metabolism


Tuesday, January 15 | 8:00AM - 11:15AM
Calcium Signaling in Muscle Mitochondria
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 8 of 10
Denis Vecellio Reane, University of Padova, Italy
Short Talk: A MICU1 Splice Variant Confers High Sensitivity to the Ca2+ Uptake Machinery of Skeletal Muscle


Tuesday, January 15 | 8:00AM - 11:15AM
Calcium Signaling in Muscle Mitochondria
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 9 of 10
Olha Koval, University of Iowa, USA
Short Talk: Mitochondrial Ca2+ Uptake via MCU Controls Cell Proliferation through CaMKII and Drp-1


Tuesday, January 15 | 8:00AM - 11:15AM
Calcium Signaling in Muscle Mitochondria
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 10 of 10
Luiz H. M. Bozi, University of São Paulo, Brazil
Short Talk: Inhibition of Mitochondrial Unfolded Protein Response (mtUPR) Mediates Doxorubicin-Induced Cardiotoxicity


Tuesday, January 15 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, January 15 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Tuesday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Tuesday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 15 | 5:00PM - 7:00PM
Mitochondrial Metabolism in Aging
Room: Grays Peak

Speaker 1 of 6
* Holly Van Remmen, Oklahoma Medical Research Foundation, USA

Tuesday, January 15 | 5:00PM - 7:00PM
Mitochondrial Metabolism in Aging
Room: Grays Peak

Speaker 2 of 6
Noga Ron-Harel, Technion-Israel Institute of Technology, Israel
Mitochondrial Metabolism in T Cell Activation and Aging

Tuesday, January 15 | 5:00PM - 7:00PM
Mitochondrial Metabolism in Aging
Room: Grays Peak

Speaker 3 of 6
Matthew D. Hirschey, Duke University, USA
Sirtuins Control Mitochondrial Metabolism and Aging

Tuesday, January 15 | 5:00PM - 7:00PM
Mitochondrial Metabolism in Aging
Room: Grays Peak

Speaker 4 of 6
Hazel H. Szeto, Social Profit Network Research Laboratory, USA
Cardiolipin-Targeted Peptides Rejuvenate Mitochondrial Function, Remodel Mitochondria, and Promote Tissue Regeneration during Aging

Tuesday, January 15 | 5:00PM - 7:00PM
Mitochondrial Metabolism in Aging
Room: Grays Peak

Speaker 5 of 6
Adam L. Hughes, University of Utah, USA
Short Talk: Dissecting the Metabolic Connection Between Mitochondria and Lysosomes in Aging

Tuesday, January 15 | 5:00PM - 7:00PM
Mitochondrial Metabolism in Aging
Room: Grays Peak

Speaker 6 of 6
Jennifer Baily, University of California, Davis, USA
Short Talk: Alternating Phases of AMPK and mTORC1: A Potential Mechanism of Mitochondrial Biogenesis during Electron
Transport Chain Inhibition


Tuesday, January 15 | 5:00PM - 7:00PM
Novel Regulators of Mitochondrial Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 1 of 7
* Liming Pei, Children's Hospital of Philadelphia/University of Pennsylvania, USA


Tuesday, January 15 | 5:00PM - 7:00PM
Novel Regulators of Mitochondrial Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 2 of 7
* Ryan L. Boudreau, University of Iowa, USA


Tuesday, January 15 | 5:00PM - 7:00PM
Novel Regulators of Mitochondrial Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 3 of 7
Andrea L. Hevener, University of California, Los Angeles, USA
Estrogen Regulation of Skeletal Muscle Mitochondria and Insulin Sensitivity


Tuesday, January 15 | 5:00PM - 7:00PM
Novel Regulators of Mitochondrial Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 4 of 7
Daniel P. Kelly, University of Pennsylvania, USA
Cardiac Mitochondrial Remodeling in Health and Disease



Tuesday, January 15 | 5:00PM - 7:00PM
Novel Regulators of Mitochondrial Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 5 of 7
Karyn A. Esser, University of Florida, USA
Circadian Regulation of Skeletal Muscle Mitochondrial Metabolism


Tuesday, January 15 | 5:00PM - 7:00PM
Novel Regulators of Mitochondrial Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 6 of 7
Weiwei Fan, The Salk Institute for Biological Studies, USA
Short Talk: Estrogen-Related Receptors a and ? are Master Regulators of Innate and Adaptive Mitochondrial Energy Metabolism in Muscle


Tuesday, January 15 | 5:00PM - 7:00PM
Novel Regulators of Mitochondrial Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 7 of 7
Julien Delezie, University of Basel, Switzerland
Short Talk: PER2 is a Potent Regulator of Mitochondrial Function in Mouse Skeletal Muscle


Tuesday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Tuesday, January 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Red Cloud/Shavano/Torreys


Wednesday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Wednesday, January 16 | 8:00AM - 11:00AM
Mitochondrial Signaling in Aging
Room: Grays Peak

Speaker 1 of 8
* Carlos T. Moraes, University of Miami, USA

Wednesday, January 16 | 8:00AM - 11:00AM
Mitochondrial Signaling in Aging
Room: Grays Peak

Speaker 2 of 8
Navdeep S. Chandel, Northwestern University, USA
Mitochondria as Signaling Organelles

Wednesday, January 16 | 8:00AM - 11:00AM
Mitochondrial Signaling in Aging
Room: Grays Peak

Speaker 3 of 8
Tamas L. Horvath, Yale School of Medicine, USA
Hypothalamic Mitochondrial Dynamics in Homeostatic Control and Aging

Wednesday, January 16 | 8:00AM - 11:00AM
Mitochondrial Signaling in Aging
Room: Grays Peak


Coffee Break

Wednesday, January 16 | 8:00AM - 11:00AM
Mitochondrial Signaling in Aging
Room: Grays Peak

Speaker 5 of 8
Gerald S. Shadel, The Salk Institute for Biological Studies, USA
Adaptive, Anti-Aging Responses to Mitochondrial Stress: From Yeast to Mammals

Wednesday, January 16 | 8:00AM - 11:00AM
Mitochondrial Signaling in Aging
Room: Grays Peak

Speaker 6 of 8
Jose M. Cuezva, Universidad Autónoma de Madrid, Spain
ATPase Inhibitory Factor 1 (IF1), a Driver of Mitochondrial/Nuclear Genome Signaling Pathways

Wednesday, January 16 | 8:00AM - 11:00AM
Mitochondrial Signaling in Aging
Room: Grays Peak

Speaker 7 of 8
Gavin Pharaoh, University of Oklahoma Health Sciences Center, USA
Short Talk: Central and Peripheral Effects of IGF-1 Deficiency on Tissue Mitochondrial Function

Wednesday, January 16 | 8:00AM - 11:00AM
Mitochondrial Signaling in Aging
Room: Grays Peak

Speaker 8 of 8
Robert Radford, The Salk Institute for Biological Studies, USA
Short Talk: TIN2: A Mitochondrial Effector of Telomere Status in Aging

Wednesday, January 16 | 8:00AM - 11:15AM
Mitochondria and Cell Death
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 1 of 9
* Anton M. Bennett, Yale University School Of Medicine, USA


Wednesday, January 16 | 8:00AM - 11:15AM
Mitochondria and Cell Death
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 2 of 9
Junichi Sadoshima, Rutgers New Jersey Medical School, USA
Autophagy and Mitochondrial Dysfunction in Heart Failure


Wednesday, January 16 | 8:00AM - 11:15AM
Mitochondria and Cell Death
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 3 of 9
Åsa B. Gustafsson, University of California, San Diego, USA
Beclin1 as a Key Regulator of Mitochondrial Quality Control


Wednesday, January 16 | 8:00AM - 11:15AM
Mitochondria and Cell Death
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak


Coffee Break


Wednesday, January 16 | 8:00AM - 11:15AM
Mitochondria and Cell Death
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 5 of 9
Gerald W. Dorn, II, Washington University School of Medicine, USA
Cardiomitopathy – Novel Cardiomyopathy of Dysfunctional Mitochondria


Wednesday, January 16 | 8:00AM - 11:15AM
Mitochondria and Cell Death
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 6 of 9
Hiromi Sesaki, Johns Hopkins University School of Medicine, USA
Mitochondrial Dynamics and Mitophagy


Wednesday, January 16 | 8:00AM - 11:15AM
Mitochondria and Cell Death
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 7 of 9
Juyoun Beak, University of North Carolina, USA
Short Talk: The Nuclear Receptor RORa Plays Critical Roles in Mitochondrial Quality Control


Wednesday, January 16 | 8:00AM - 11:15AM
Mitochondria and Cell Death
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 8 of 9
Payam Anthony Gammage, University of Cambridge, UK
Short Talk: Genome Editing in Cardiac Mitochondria Corrects a Pathogenic mtDNA Mutation in vivo


Wednesday, January 16 | 8:00AM - 11:15AM
Mitochondria and Cell Death
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 9 of 9
* Joan M. Taylor, University of North Carolina at Chapel Hill, USA
Short Talk: GRAF1 is A Novel Mediator of Parkin-Dependent Mitophagy


Wednesday, January 16 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, January 16 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Wednesday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop: Mitochondrial Metabolic Signaling and Communicatio
n with Other Organelles in Aging
Room: Grays Peak

Speaker 1 of 9
* Dan Gottschling, Calico, USA

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop: Mitochondrial Metabolic Signaling and Communicatio
n with Other Organelles in Aging
Room: Grays Peak

Speaker 2 of 9
Sam Katz, Yale University School of Medicine, USA
Regulation of ER-Mitochondrial Contact Site Signaling by the BCL-2 Family Member BOK

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop: Mitochondrial Metabolic Signaling and Communicatio
n with Other Organelles in Aging
Room: Grays Peak

Speaker 3 of 9
Changhan Lee, University of Southern California and Ajou University, USA
Intergenomic Basis of Mitonuclear Communication

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop: Mitochondrial Metabolic Signaling and Communicatio
n with Other Organelles in Aging
Room: Grays Peak

Speaker 4 of 9
Nuno Raimundo, University Medical Center Goettingen, Germany
Impact of Mitochondrial Function in Aging Is Mediated by Impaired Lysosomes

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop: Mitochondrial Metabolic Signaling and Communicatio
n with Other Organelles in Aging
Room: Grays Peak

Speaker 5 of 9
Katharina Schlacher, MD Anderson Cancer Center, USA
Mitochondrial DNA Replication Fork Stability by the BRCA/Fanconi Anemia Pathway Suppresses Inflammation and Disease

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop: Mitochondrial Metabolic Signaling and Communicatio
n with Other Organelles in Aging
Room: Grays Peak

Speaker 6 of 9
Jaroslaw Waldemar Zmijewski, University of Alabama, USA
AMPK is a Therapeutic Target for Metabolic and Bioenergetic Maladaptation in Aging-Related Non-Resolving Lung Fibrosis

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop: Mitochondrial Metabolic Signaling and Communicatio
n with Other Organelles in Aging
Room: Grays Peak

Speaker 7 of 9
Ana Victoria Lechuga Vieco, Spanish National Center for Cardiovascular Research, Spain
Mitochondrial and Nuclear DNA Matching Shapes Metabolism and Healthy Ageing

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop: Mitochondrial Metabolic Signaling and Communicatio
n with Other Organelles in Aging
Room: Grays Peak

Speaker 8 of 9
Kortessa Sotiropoulou, Institute of Medical Biology, ASTAR, Singapore
The Proline Metabolic Pathway in Human Skin Ageing

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop: Mitochondrial Metabolic Signaling and Communicatio
n with Other Organelles in Aging
Room: Grays Peak

Speaker 9 of 9
Teresa Gonçalves, University of Coimbra, Portugal
Dynamics of Adenosine A2A Receptors is Associated with Increased Susceptibility to Candida Albicans Colonization and Inflammation in the Elderly

Wednesday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 16 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 1 of 7
* John P. Kirwan, Pennington Biomedical Research Center, USA


Wednesday, January 16 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 2 of 7
* Brian Timothy O'Neill, University of Iowa, Carver College of Medicine, USA


Wednesday, January 16 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 3 of 7
E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Paracrine Regulation of Metabolism by OPA1


Wednesday, January 16 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 4 of 7
Robert S. Balaban, NHLBI, National Institutes of Health, USA
The Mitochondria Reticulum of Muscle Cells


Wednesday, January 16 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 5 of 7
Antonio Zorzano, Institute for Research in Biomedicine, Spain
Mitochondrial Fusion Proteins, Metabolism and Inflammation


Wednesday, January 16 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 6 of 7
Brian Glancy, NHLBI and NIAMS, National Institutes of Health, USA
Short Talk: Intra- and Inter-Organelle Interactions within the Muscle Mitochondrial Reticulum


Wednesday, January 16 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Metabolism
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 7 of 7
Sandra S. Zinkel, Vanderbilt University, USA
Short Talk: Bid Maintains Mitochondrial Cristae Structure and Function and Protects against Cardiac Disease in an Integrative Genomics Study


Wednesday, January 16 | 5:00PM - 7:00PM
Mitochondria in Age-Related Pathology
Room: Grays Peak

Speaker 1 of 5
* Rudolf J. Wiesner, University of Cologne, Germany

Wednesday, January 16 | 5:00PM - 7:00PM
Mitochondria in Age-Related Pathology
Room: Grays Peak

Speaker 2 of 5
David J. Marcinek, University of Washington, USA
The Effects of Mitochondrial Redox Stress on Energetics and the Proteome in Aged Skeletal Muscle

Wednesday, January 16 | 5:00PM - 7:00PM
Mitochondria in Age-Related Pathology
Room: Grays Peak

Speaker 3 of 5
Scott M. Plafker, Oklahoma Medical Research Foundation, USA
Mitochondria-Associated Stress Sensing Proteins Govern Intracellular Homeostasis

Wednesday, January 16 | 5:00PM - 7:00PM
Mitochondria in Age-Related Pathology
Room: Grays Peak

Speaker 4 of 5
James B. Stewart, Max Planck Institute for Biology of Ageing, Germany
Mouse Models of Mitochondrial DNA Mutations in Disease Pathology

Wednesday, January 16 | 5:00PM - 7:00PM
Mitochondria in Age-Related Pathology
Room: Grays Peak

Speaker 5 of 5
Douglas C. Wallace, Children's Hospital of Philadelphia, USA
Nuclear-Mitochondrial Interactions in Age-Related Diseases

Wednesday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Wednesday, January 16 | 7:30PM - 10:00PM
Poster Session 3
Room: Red Cloud/Shavano/Torreys


Thursday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Thursday, January 17 | 8:00AM - 11:00AM
Mitochondria in Aging Muscle (Joint)
Room: Grays/Longs Peak

Speaker 1 of 8
* In-Kyu Lee, Kyungpook National University Hospital, South Korea

Thursday, January 17 | 8:00AM - 11:00AM
Mitochondria in Aging Muscle (Joint)
Room: Grays/Longs Peak

Speaker 2 of 8
David J. Glass, Regeneron Pharmaceuticals, Inc., USA
Mitochondria Pathways in Aging and Sarcopenia

Thursday, January 17 | 8:00AM - 11:00AM
Mitochondria in Aging Muscle (Joint)
Room: Grays/Longs Peak


Coffee Break

Thursday, January 17 | 8:00AM - 11:00AM
Mitochondria in Aging Muscle (Joint)
Room: Grays/Longs Peak

Speaker 4 of 8
Holly Van Remmen, Oklahoma Medical Research Foundation, USA
Is Mitochondrial Oxidative Stress a Determining Factor in Sarcopenia?

Thursday, January 17 | 8:00AM - 11:00AM
Mitochondria in Aging Muscle (Joint)
Room: Grays/Longs Peak

Speaker 5 of 8
Mike P. Murphy, Medical Research Council, UK
Therapeutic Targeting of Mitochondria

Thursday, January 17 | 8:00AM - 11:00AM
Mitochondria in Aging Muscle (Joint)
Room: Grays/Longs Peak

Speaker 6 of 8
Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
New Insights into the Genetics of Mitochondria and Aging

Thursday, January 17 | 8:00AM - 11:00AM
Mitochondria in Aging Muscle (Joint)
Room: Grays/Longs Peak

Speaker 7 of 8
Mitchell Allen, Virginia Tech, USA
Short Talk: The Cardiolipin-Aggregating Peptide Elamipretide Protects Mitochondrial Structure-Function

Thursday, January 17 | 8:00AM - 11:00AM
Mitochondria in Aging Muscle (Joint)
Room: Grays/Longs Peak

Speaker 8 of 8
Robert V. Musci, Colorado State University, USA
Short Talk: Nrf2 Activator Improves Mitochondrial Function and Attenuates Age-Related Musculoskeletal Dysfunction in a
Novel Guinea Pig Model


Thursday, January 17 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 17 | 5:00PM - 6:45PM
Mitochondria Dynamics and Aging
Room: Grays Peak

Speaker 1 of 5
* Richard J. Youle, NINDS, National Institutes of Health, USA

Thursday, January 17 | 5:00PM - 6:45PM
Mitochondria Dynamics and Aging
Room: Grays Peak

Speaker 2 of 5
Liza A. Pon, Columbia University Medical Center, USA
Inheritance of the Fittest Mitochondria and Lifespan Control in Budding Yeast

Thursday, January 17 | 5:00PM - 6:45PM
Mitochondria Dynamics and Aging
Room: Grays Peak

Speaker 3 of 5
Monica Driscoll, Rutgers University, USA
Throwing It Away: Neuronal Extrusion of Trashy Mitochondria as a Mito-Stasis Strategy

Thursday, January 17 | 5:00PM - 6:45PM
Mitochondria Dynamics and Aging
Room: Grays Peak

Speaker 4 of 5
Lisa Norquay, Janssen, USA
Mitochondrial Dynamics and Mitophagy in Metabolic Disease

Thursday, January 17 | 5:00PM - 6:45PM
Mitochondria Dynamics and Aging
Room: Grays Peak

Speaker 5 of 5
Sofie Hindkjaer Lautrup, University of Oslo and Akershus University Hospital, Norway
Short Talk: NAD+ Prevents Accelerated Aging in Werner Syndrome by Induction of Mitophagy

Thursday, January 17 | 5:00PM - 7:00PM
Mitochondria, Energy Expenditure and Insulin Sensitivity
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 1 of 7
* Anastasia Kralli, Johns Hopkins Medical School, USA


Thursday, January 17 | 5:00PM - 7:00PM
Mitochondria, Energy Expenditure and Insulin Sensitivity
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 2 of 7
* Weiwei Fan, The Salk Institute for Biological Studies, USA


Thursday, January 17 | 5:00PM - 7:00PM
Mitochondria, Energy Expenditure and Insulin Sensitivity
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 3 of 7
Patrick Schrauwen, Maastricht University, Netherlands
Human Skeletal Muscle Mitochondrial function and Insulin Sensitivity


Thursday, January 17 | 5:00PM - 7:00PM
Mitochondria, Energy Expenditure and Insulin Sensitivity
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 4 of 7
Mary-Ellen Harper, University of Ottawa, Canada
Skeletal Muscle Mitochondrial Energetics in Diet-Resistant and Diet-Sensitive Obesity


Thursday, January 17 | 5:00PM - 7:00PM
Mitochondria, Energy Expenditure and Insulin Sensitivity
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 5 of 7
Francesca Amati, University of Lausanne, Switzerland
Mitochondria and Substrate Switches


Thursday, January 17 | 5:00PM - 7:00PM
Mitochondria, Energy Expenditure and Insulin Sensitivity
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 6 of 7
Yvan Ricardo Campos, St. Jude Children's Research Hospital, USA
Short Talk: Mitochondrial Defects in Ozz and Alix Knockout Mouse Models


Thursday, January 17 | 5:00PM - 7:00PM
Mitochondria, Energy Expenditure and Insulin Sensitivity
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak

Speaker 7 of 7
Danielle S. Murashige, University of Pennsylvania, USA
Short Talk: Promotion of Specifically Cardiac Branched Chain Amino Acid Metabolism does not Prevent Cardiac Remodeling


Thursday, January 17 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Grays Peak


Thursday, January 17 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Mito, Heart & Skeletal Muscle
Room: Longs Peak


Thursday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Thursday, January 17 | 8:00PM - 11:00PM
Entertainment
Room: Red Cloud/Shavano/Torreys
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 17 | 8:00PM - 11:00PM
Cash Bar
Room: Red Cloud/Shavano/Torreys


Friday, January 18 | 10:24AM - 10:24AM
Departure


*Session Chair.