Web Desc
Cellular Plasticity: Reprogramming, Regeneration and Metaplasia
joint with Signal Dynamics and Signal Integration in Development and Disease
Organizer(s): Jason C. Mills, Maike Sander and Ben Z. Stanger
Date: January 27 - 31, 2019
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Novartis Institutes for BioMedical Research
For important information on the coronavirus, please click here
Summary of Meeting:
Traditionally, differentiated cells were thought to be post-mitotic. However, now we know mature cells in diverse tissues can reprogram, re-enter the cell cycle, and spawn other lineages (e.g., they revert back to stem cells or adopt other identities). The scientific and health implications are substantial. For one, cellular plasticity might be harnessed to regenerate damaged tissue (e.g., insulin-secreting cells, liver, gut), but repeated reprogramming events – as cells respond to inflammation/injury – can also cause tissue derangement (metaplasia) that predisposes to cancer. Furthermore, cancer cells can harness such plasticity mechanisms to subvert therapy. Thus, defining the mechanisms that allow mature cells to switch identities holds great promise for understanding disease pathogenesis and developing new therapies. This conference gathers the diverse, dynamic field of plasticity/reprogramming together for the first time with the aim of understanding if similar mechanisms underlie plasticity in diverse organs and organisms. The hypothesis is that cellular reprogramming occurs via evolutionarily conserved cellular processes as fundamental to a multicellular organism as apoptosis. Specifically, the conference aims to: 1) Elucidate mechanisms of plasticity in diverse adult tissues; 2) Explore plasticity’s evolutionary context; 3) Elucidate its role in metaplasia/cancer; and 4) Investigate how it can be harnessed therapeutically.
Scholarship Deadline: October 17 2018
Discounted Abstract Deadline: October 17 2018
Abstract Deadline: October 25 2018
Discounted Registration Deadline: November 28 2018
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Novartis Institutes for BioMedical Research
We gratefully acknowledge additional support from these exhibitors at this conference:
10x Genomics
We gratefully acknowledge additional support for this conference from:
Integra Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 27 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, January 27 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Monday, January 28 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Grays/Longs Peak

Speaker 1 of 3
* Jason C. Mills, Washington University, USA

Monday, January 28 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Grays/Longs Peak

Speaker 2 of 3
* Nicolas Tapon, Francis Crick Institute, UK

Monday, January 28 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Grays/Longs Peak

Speaker 3 of 3
Hans C. Clevers, Hubrecht Institute, Netherlands
Lgr5 Stem Cell-Based Organoids in Human Disease

Monday, January 28 | 9:00AM - 11:30AM
Plasticity and Signaling in Development and Homeostasis (Joi
nt)

Room: Grays/Longs Peak

Speaker 1 of 8
* Anna Mae Diehl, Duke University, USA

Monday, January 28 | 9:00AM - 11:30AM
Plasticity and Signaling in Development and Homeostasis (Joi
nt)

Room: Grays/Longs Peak

Speaker 2 of 8
* Michael B. O'Connor, University of Minnesota, Twin Cities, USA

Monday, January 28 | 9:00AM - 11:30AM
Plasticity and Signaling in Development and Homeostasis (Joi
nt)

Room: Grays/Longs Peak

Speaker 3 of 8
Jayaraj Rajagopal, Massachusetts General Hospital, USA
The Airway Epithelial Ensemble

Monday, January 28 | 9:00AM - 11:30AM
Plasticity and Signaling in Development and Homeostasis (Joi
nt)

Room: Grays/Longs Peak


Coffee Break

Monday, January 28 | 9:00AM - 11:30AM
Plasticity and Signaling in Development and Homeostasis (Joi
nt)

Room: Grays/Longs Peak

Speaker 5 of 8
Ophir Klein, University of California, San Francisco, USA
Renewal and Plasticity in Oral Epithelia

Monday, January 28 | 9:00AM - 11:30AM
Plasticity and Signaling in Development and Homeostasis (Joi
nt)

Room: Grays/Longs Peak

Speaker 6 of 8
Valentina Greco, Yale School of Medicine, USA
Principles of Tissue Dynamics and Function Captured by Live Imaging

Monday, January 28 | 9:00AM - 11:30AM
Plasticity and Signaling in Development and Homeostasis (Joi
nt)

Room: Grays/Longs Peak

Speaker 7 of 8
Erin N. Sanders, Stanford University, USA
Short Talk: Real-Time Kinetics of Notch-Mediated Fate Decisions during Organ Renewal

Monday, January 28 | 9:00AM - 11:30AM
Plasticity and Signaling in Development and Homeostasis (Joi
nt)

Room: Grays/Longs Peak

Speaker 8 of 8
Shiyan Yu, Rutgers University-Newark, USA
Short Talk: Injury Induces Paneth Cell Plasticity


Monday, January 28 | 11:30AM - 12:30PM
Meet the Editors (Joint)
Room: Grays/Longs Peak
Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science?
Speaker 1 of 7
* Daniel Klimmeck, EMBO Journal, Germany

Monday, January 28 | 11:30AM - 12:30PM
Meet the Editors (Joint)
Room: Grays/Longs Peak
Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science?
Speaker 2 of 7
* Sheila Chari, Cell Press, USA

Monday, January 28 | 11:30AM - 12:30PM
Meet the Editors (Joint)
Room: Grays/Longs Peak
Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science?
Speaker 3 of 7
Iain Dickson, Nature Reviews, UK

Monday, January 28 | 11:30AM - 12:30PM
Meet the Editors (Joint)
Room: Grays/Longs Peak
Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science?
Speaker 4 of 7
John F. Foley, Science Signaling, USA

Monday, January 28 | 11:30AM - 12:30PM
Meet the Editors (Joint)
Room: Grays/Longs Peak
Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science?
Speaker 5 of 7
Seema Grewal, Development, UK

Monday, January 28 | 11:30AM - 12:30PM
Meet the Editors (Joint)
Room: Grays/Longs Peak
Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science?
Speaker 6 of 7
Marie Bao, Cell Press, USA

Monday, January 28 | 11:30AM - 12:30PM
Meet the Editors (Joint)
Room: Grays/Longs Peak
Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science?
Speaker 7 of 7
Jessie Ann Le Good, Nature Communications, UK

Monday, January 28 | 11:30AM - 5:00PM
On Own for Lunch


Monday, January 28 | 11:30AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Monday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Monday, January 28 | 2:30PM - 4:30PM
Workshop
Room: Grays Peak

Speaker 1 of 8
* Chay T. Kuo, Duke University School of Medicine, USA

Monday, January 28 | 2:30PM - 4:30PM
Workshop
Room: Grays Peak

Speaker 2 of 8
Lorin Olson, Oklahoma Medical Research Foundation, USA
Mosaic Mutant Analysis Identifies PDGFRa/PDGFRb as Regulators of Adipocyte Progenitor Cell Plasticity

Monday, January 28 | 2:30PM - 4:30PM
Workshop
Room: Grays Peak

Speaker 3 of 8
Feng Chen, University of California, San Francisco, USA
Resolving the Contribution of Adult Liver Stem/Progenitor Cells to Hepatocyte Regeneration with a Dual AAV Vector System for Inducing Liver Injury and Lineage Tracing

Monday, January 28 | 2:30PM - 4:30PM
Workshop
Room: Grays Peak

Speaker 4 of 8
Kenji Ito, University of Tokyo, Japan
Cancer Drug Screening Based on Refractoriness of Cancer Cell Reprogramming

Monday, January 28 | 2:30PM - 4:30PM
Workshop
Room: Grays Peak

Speaker 5 of 8
Enric Llorens-Bobadilla, Karolinska Institute, Sweden
Programming Future Fate Decisions in the Glial Scar to Promote Spinal Cord Injury Repair

Monday, January 28 | 2:30PM - 4:30PM
Workshop
Room: Grays Peak

Speaker 6 of 8
Agnieszka B. Bialkowska, Stony Brook University, USA
Krüppel-Like Factor 5 Plays an Important Role in Acinar-to-Ductal Metaplasia of the Pancreas

Monday, January 28 | 2:30PM - 4:30PM
Workshop
Room: Grays Peak

Speaker 7 of 8
Oscar Pellon-Cardenas, Rutgers University, USA
CDX2 Loss Disrupts the Differentiation-Proliferation Balance during Initiation and Progression of Intestinal Tumors

Monday, January 28 | 2:30PM - 4:30PM
Workshop
Room: Grays Peak

Speaker 8 of 8
Lianghui Zhang, University of Illinois at Chicago, USA
Differential Pathogen Response Mechanisms and Single Cell Heterogeneity in Endothelial Regeneration

Monday, January 28 | 2:30PM - 4:30PM
Workshop
This session is from Developmental Signaling
Room: Longs Peak

Speaker 1 of 6
* Silvia Santos, Francis Crick Institute, UK


Monday, January 28 | 2:30PM - 4:30PM
Workshop
This session is from Developmental Signaling
Room: Longs Peak

Speaker 2 of 6
Julie B. Sneddon, University California, San Francisco, USA
Cell Fate Determination in Human Pancreatic Endocrine Development


Monday, January 28 | 2:30PM - 4:30PM
Workshop
This session is from Developmental Signaling
Room: Longs Peak

Speaker 3 of 6
Micha Sam Brickman Raredon, Yale University, USA
Cross-Species scRNAseq Analysis of Cell-Cell Connectomics in Lung


Monday, January 28 | 2:30PM - 4:30PM
Workshop
This session is from Developmental Signaling
Room: Longs Peak

Speaker 4 of 6
Jarod Zepp, University of Pennsylvania, USA
Epithelial to Mesenchymal Crosstalk during the Postnatal Phase of Lung Development Coordinates Lineage Commitment and Niche Formation


Monday, January 28 | 2:30PM - 4:30PM
Workshop
This session is from Developmental Signaling
Room: Longs Peak

Speaker 5 of 6
Oliver Wessely, Cleveland Clinic Foundation, USA
A Design-of-Experiment Approach Towards Differentiation of Human Pluripotent Stem Cells into Definitive Kidney Cell Lineages


Monday, January 28 | 2:30PM - 4:30PM
Workshop
This session is from Developmental Signaling
Room: Longs Peak

Speaker 6 of 6
Akiko Mammoto, Medical College of Wisconsin, USA
Effects of Age-Dependent Changes in Cell Size on Endothelial Cell Growth through YAP1


Monday, January 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 28 | 5:00PM - 7:00PM
Stem Cell Recruitment and Metaplasia
Room: Grays Peak

Speaker 1 of 5
* Eunyoung Choi, Vanderbilt University Medical Center, USA

Monday, January 28 | 5:00PM - 7:00PM
Stem Cell Recruitment and Metaplasia
Room: Grays Peak

Speaker 2 of 5
Calvin Kuo, Stanford University, USA
Intestinal Stem Cell Niches

Monday, January 28 | 5:00PM - 7:00PM
Stem Cell Recruitment and Metaplasia
Room: Grays Peak

Speaker 3 of 5
James R. Goldenring, Vanderbilt University Medical Center, USA
Inflammatory Regulation of Metaplasia Induction in the Stomach

Monday, January 28 | 5:00PM - 7:00PM
Stem Cell Recruitment and Metaplasia
Room: Grays Peak

Speaker 4 of 5
Jason C. Mills, Washington University, USA
Reserve Stem Cells Recruited by Paligenosis, an Evolutionarily Conserved Program

Monday, January 28 | 5:00PM - 7:00PM
Stem Cell Recruitment and Metaplasia
Room: Grays Peak

Speaker 5 of 5
Melissa Hirose Wong, Oregon Health & Science University, USA
Short Talk: Macrophage-Cancer Stem Cell Fusion Underlies Cancer Cell Plasticity and Potentiates Metastatic Spread of Disease

Monday, January 28 | 5:00PM - 7:00PM
Quantitative Approaches and Signaling Networks
This session is from Developmental Signaling
Room: Longs Peak

Speaker 1 of 6
* Anna Kicheva, Institute of Science and Technology Austria, Austria


Monday, January 28 | 5:00PM - 7:00PM
Quantitative Approaches and Signaling Networks
This session is from Developmental Signaling
Room: Longs Peak

Speaker 2 of 6
Michael Elowitz, California Institute of Technology, USA
Communication and Computation in Protein Circuits


Monday, January 28 | 5:00PM - 7:00PM
Quantitative Approaches and Signaling Networks
This session is from Developmental Signaling
Room: Longs Peak

Speaker 3 of 6
Ertugrul M. Ozbudak, Cincinnati Children's Hospital Medical Center, USA
Spatial Fold-Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish


Monday, January 28 | 5:00PM - 7:00PM
Quantitative Approaches and Signaling Networks
This session is from Developmental Signaling
Room: Longs Peak

Speaker 4 of 6
Mary N. Teruel, Stanford University, USA
Control of Cell Differentiation by Timing and Phase-Shifting of Physiological Oscillators


Monday, January 28 | 5:00PM - 7:00PM
Quantitative Approaches and Signaling Networks
This session is from Developmental Signaling
Room: Longs Peak

Speaker 5 of 6
Jared Toettcher, Princeton University, USA
Short Talk: Cellular Optogenetics Reveals Principles of Cell Fate Control in the Early Drosophila Embryo


Monday, January 28 | 5:00PM - 7:00PM
Quantitative Approaches and Signaling Networks
This session is from Developmental Signaling
Room: Longs Peak

Speaker 6 of 6
Amanda L. Zacharias, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Comprehensive Quantitative Analysis of Nuclear ß-catenin in C. elegans Embryos Identifies a Novel Memory Mechanism for Gene Expression Diversification


Monday, January 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Monday, January 28 | 7:30PM - 10:00PM
Poster Session 1
Room: Red Cloud/Shavano/Torreys


Tuesday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Tuesday, January 29 | 8:00AM - 11:15AM
Cancer and Plasticity
Room: Grays Peak

Speaker 1 of 9
* Blair B. Madison, Washington University, USA

Tuesday, January 29 | 8:00AM - 11:15AM
Cancer and Plasticity
Room: Grays Peak

Speaker 2 of 9
Arjun Raj, University of Pennsylvania, USA
Controlling Cellular Plasticity in Cancer

Tuesday, January 29 | 8:00AM - 11:15AM
Cancer and Plasticity
Room: Grays Peak

Speaker 3 of 9
Ben Z. Stanger, University of Pennsylvania, USA
Epithelial-Mesenchymal Plasticity in Cancer Cell Invasion and Metastasis

Tuesday, January 29 | 8:00AM - 11:15AM
Cancer and Plasticity
Room: Grays Peak


Coffee Break

Tuesday, January 29 | 8:00AM - 11:15AM
Cancer and Plasticity
Room: Grays Peak

Speaker 5 of 9
Carla F. Kim, Boston Children's Hospital, USA
Regulation of Progenitor Cells in the Adult Lung

Tuesday, January 29 | 8:00AM - 11:15AM
Cancer and Plasticity
Room: Grays Peak

Speaker 6 of 9
Cory T. Abate-Shen, Columbia University Medical Center, USA
Cellular Plasticity in Prostate Cancer

Tuesday, January 29 | 8:00AM - 11:15AM
Cancer and Plasticity
Room: Grays Peak

Speaker 7 of 9
Rohit Chandwani, Weill Cornell Medicine, USA
Short Talk: Chromatin Dynamics in vivo Reveal the Complexity of Cell Fate Transitions in Pancreatic Cancer Initiation

Tuesday, January 29 | 8:00AM - 11:15AM
Cancer and Plasticity
Room: Grays Peak

Speaker 8 of 9
Ellen M. Langer, Oregon Health & Science University, USA
Short Talk: The Prolyl Isomerase PIN1 Plays a Critical Role in Pancreatic Stellate Cell Plasticity to Impact Tumor Development

Tuesday, January 29 | 8:00AM - 11:15AM
Cancer and Plasticity
Room: Grays Peak

Speaker 9 of 9
Karuna Ganesh, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Regenerative Origin of Metastasis-Initiating Cells

Tuesday, January 29 | 8:00AM - 11:00AM
Signaling Dynamics
This session is from Developmental Signaling
Room: Longs Peak

Speaker 1 of 9
* Dan Shaye, University of Illinois at Chicago, USA


Tuesday, January 29 | 8:00AM - 11:00AM
Signaling Dynamics
This session is from Developmental Signaling
Room: Longs Peak

Speaker 2 of 9
Vivian Li, Francis Crick Institute, UK
Wnt Signal Rregulation in Intestinal Stem Cells and Cancer


Tuesday, January 29 | 8:00AM - 11:00AM
Signaling Dynamics
This session is from Developmental Signaling
Room: Longs Peak

Speaker 3 of 9
Deborah L. Gumucio, University of Michigan, USA
Dynamic Roles for WNT5a During Morphogenesis of the Mouse Fetal Intestine


Tuesday, January 29 | 8:00AM - 11:00AM
Signaling Dynamics
This session is from Developmental Signaling
Room: Longs Peak


Coffee Break


Tuesday, January 29 | 8:00AM - 11:00AM
Signaling Dynamics
This session is from Developmental Signaling
Room: Longs Peak

Speaker 5 of 9
Raphael Kopan, University of Cincinnati College of Medicine, USA
A Role for Notch Dimerization and CSL Binding-Site Architecture in Mammalian Development and Tissue Maintenance


Tuesday, January 29 | 8:00AM - 11:00AM
Signaling Dynamics
This session is from Developmental Signaling
Room: Longs Peak

Speaker 6 of 9
Victoria Ng, Vanderbilt University, USA
Short Talk: The USP46 Complex Promotes Wnt Signaling by Blocking Receptor Turnover


Tuesday, January 29 | 8:00AM - 11:00AM
Signaling Dynamics
This session is from Developmental Signaling
Room: Longs Peak

Speaker 7 of 9
Sergi Regot, Johns Hopkins University, USA
Short Talk: Single Cell Analysis of MAPK Signaling Dynamics in Multicellular Systems


Tuesday, January 29 | 8:00AM - 11:00AM
Signaling Dynamics
This session is from Developmental Signaling
Room: Longs Peak

Speaker 8 of 9
David Sprinzak, Tel Aviv University, Israel
Short Talk: Localized Feedbacks on Fat4-Ds1 Complexes Underlie Planar Cell Polarity


Tuesday, January 29 | 8:00AM - 11:00AM
Signaling Dynamics
This session is from Developmental Signaling
Room: Longs Peak

Speaker 9 of 9
Kaelyn Sumigray, Duke University School of Medicine, USA
Short Talk: Morphogenesis and Compartmentalization of the Mammalian Intestine


Tuesday, January 29 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, January 29 | 11:15AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Tuesday, January 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Tuesday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 29 | 5:00PM - 7:00PM
Reprogramming Cells to Assemble and Repair Organs
Room: Grays Peak

Speaker 1 of 6
* Sydney Shaffer, University of Pennsylvania, USA

Tuesday, January 29 | 5:00PM - 7:00PM
Reprogramming Cells to Assemble and Repair Organs
Room: Grays Peak

Speaker 2 of 6
Jason R. Spence, University of Michigan Health System, USA
Intestinal Organoids

Tuesday, January 29 | 5:00PM - 7:00PM
Reprogramming Cells to Assemble and Repair Organs
Room: Grays Peak

Speaker 3 of 6
Takanori Takebe, Cincinnati Children's Hospital Medical Center, Japan
Next-Gen Organoids from Pluripotency

Tuesday, January 29 | 5:00PM - 7:00PM
Reprogramming Cells to Assemble and Repair Organs
Room: Grays Peak

Speaker 4 of 6
Frederic J. de Sauvage, Genentech, Inc., USA
Targeting Intestinal Stem Cells in Cancer

Tuesday, January 29 | 5:00PM - 7:00PM
Reprogramming Cells to Assemble and Repair Organs
Room: Grays Peak

Speaker 5 of 6
Purushothama Rao Rao Tata, Duke University School of Medicine, USA
Short Talk: Stem Cells and Reserve Stem Cells in the Lung

Tuesday, January 29 | 5:00PM - 7:00PM
Reprogramming Cells to Assemble and Repair Organs
Room: Grays Peak

Speaker 6 of 6
Qiong Wang, City of Hope/BRI, USA
Short Talk: Reversible Dedifferentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation

Tuesday, January 29 | 5:00PM - 7:00PM
Morphogen Gradients in Growth and Patterning
This session is from Developmental Signaling
Room: Longs Peak

Speaker 1 of 6
* Kaelyn Sumigray, Duke University School of Medicine, USA


Tuesday, January 29 | 5:00PM - 7:00PM
Morphogen Gradients in Growth and Patterning
This session is from Developmental Signaling
Room: Longs Peak

Speaker 2 of 6
Caroline S. Hill, Francis Crick Institute, UK
Self-Organizing Pattern Formation in Endoderm Specification in Zebrafish


Tuesday, January 29 | 5:00PM - 7:00PM
Morphogen Gradients in Growth and Patterning
This session is from Developmental Signaling
Room: Longs Peak

Speaker 3 of 6
Anna Kicheva, Institute of Science and Technology Austria, Austria
Coordination of Progenitor Specification and Growth in the Developing Spinal Cord


Tuesday, January 29 | 5:00PM - 7:00PM
Morphogen Gradients in Growth and Patterning
This session is from Developmental Signaling
Room: Longs Peak

Speaker 4 of 6
Jean-Paul B. Vincent, Francis Crick Institute, UK
Coordination of Growth and Patterning in a Developing Epithelium


Tuesday, January 29 | 5:00PM - 7:00PM
Morphogen Gradients in Growth and Patterning
This session is from Developmental Signaling
Room: Longs Peak

Speaker 5 of 6
Jennifer Kong, Stanford University, USA
Short Talk: Molecular Mechanisms that Regulate Target Cell Sensitivity to Hedgehog Morphogens


Tuesday, January 29 | 5:00PM - 7:00PM
Morphogen Gradients in Growth and Patterning
This session is from Developmental Signaling
Room: Longs Peak

Speaker 6 of 6
Shinji Takada, National Institute for Basic Biology, Japan
Short Talk: Extracellular Dynamics and Diffusion Range of Wnt Protein Complex in Xenopus Embryos


Tuesday, January 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Tuesday, January 29 | 7:30PM - 10:00PM
Poster Session 2
Room: Red Cloud/Shavano/Torreys


Wednesday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Wednesday, January 30 | 8:00AM - 11:00AM
Plasticity and Signaling in Regeneration and Tumorigenesis (
Joint)

Room: Grays/Longs Peak

Speaker 1 of 9
* Caroline S. Hill, Francis Crick Institute, UK

Wednesday, January 30 | 8:00AM - 11:00AM
Plasticity and Signaling in Regeneration and Tumorigenesis (
Joint)

Room: Grays/Longs Peak

Speaker 2 of 9
* Thea D. Tlsty, University of California, San Francisco, USA

Wednesday, January 30 | 8:00AM - 11:00AM
Plasticity and Signaling in Regeneration and Tumorigenesis (
Joint)

Room: Grays/Longs Peak

Speaker 3 of 9
Jeffrey L. Wrana, Mount Sinai Hospital, Canada
Revival Stem Cells Regenerate the Intestine

Wednesday, January 30 | 8:00AM - 11:00AM
Plasticity and Signaling in Regeneration and Tumorigenesis (
Joint)

Room: Grays/Longs Peak

Speaker 4 of 9
Maike Sander, University of California, San Diego, USA
Deconstructing Endodermal Organ Development to Reconstruct Organs From Stem Cells

Wednesday, January 30 | 8:00AM - 11:00AM
Plasticity and Signaling in Regeneration and Tumorigenesis (
Joint)

Room: Grays/Longs Peak


Coffee Break

Wednesday, January 30 | 8:00AM - 11:00AM
Plasticity and Signaling in Regeneration and Tumorigenesis (
Joint)

Room: Grays/Longs Peak

Speaker 6 of 9
Stacey S. Huppert, Cincinnati Children’s Hospital Medical Center, USA
Building a Functional Biliary System via Hepatocyte Plasticity

Wednesday, January 30 | 8:00AM - 11:00AM
Plasticity and Signaling in Regeneration and Tumorigenesis (
Joint)

Room: Grays/Longs Peak

Speaker 7 of 9
Owen J. Sansom, Beatson Institute of Cancer Research, UK
Reserve Stem Cells and Intestinal Tumorigenesis: Foetal Progenitors and Microbiome in Colorectal Cancer

Wednesday, January 30 | 8:00AM - 11:00AM
Plasticity and Signaling in Regeneration and Tumorigenesis (
Joint)

Room: Grays/Longs Peak

Speaker 8 of 9
Margaret E. Magaletta, University of Massachusetts Medical School, USA
Short Talk: Single Cell Transcriptomic Analysis Resolves Dynamics of Developing Pharyngeal Endoderm

Wednesday, January 30 | 8:00AM - 11:00AM
Plasticity and Signaling in Regeneration and Tumorigenesis (
Joint)

Room: Grays/Longs Peak

Speaker 9 of 9
P. Duc Si Dong, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Biliary Paucity Due Jagged/Notch Loss is Reversible via a Novel Non-Hepatic Multipotent Cell Population

Wednesday, January 30 | 11:00AM - 12:00PM
Panel: Nomenclature in Cell Plasticity: 'Plasticity,' 'Dedif
ferentiation,' 'Transdifferentiation,' 'Reprogramming,' 'Reversion,' 'Paligenosis' – Can We Agree What These Mean?
Room: Grays/Longs Peak
This session will seek to examine the utility of critical terms relating to cellular plasticity through an open discussion among the panelists and the audience. Particular topics will include: 1) What is dedifferentiation?; 2) What is transdifferentiation?; 3) Are more specific terms required to describe plasticity pathways?; and 4) What are the implications of terms such as metaplasia?
Speaker 1 of 3
James R. Goldenring, Vanderbilt University Medical Center, USA

Wednesday, January 30 | 11:00AM - 12:00PM
Panel: Nomenclature in Cell Plasticity: 'Plasticity,' 'Dedif
ferentiation,' 'Transdifferentiation,' 'Reprogramming,' 'Reversion,' 'Paligenosis' – Can We Agree What These Mean?
Room: Grays/Longs Peak
This session will seek to examine the utility of critical terms relating to cellular plasticity through an open discussion among the panelists and the audience. Particular topics will include: 1) What is dedifferentiation?; 2) What is transdifferentiation?; 3) Are more specific terms required to describe plasticity pathways?; and 4) What are the implications of terms such as metaplasia?
Speaker 2 of 3
Anna Mae Diehl, Duke University, USA

Wednesday, January 30 | 11:00AM - 12:00PM
Panel: Nomenclature in Cell Plasticity: 'Plasticity,' 'Dedif
ferentiation,' 'Transdifferentiation,' 'Reprogramming,' 'Reversion,' 'Paligenosis' – Can We Agree What These Mean?
Room: Grays/Longs Peak
This session will seek to examine the utility of critical terms relating to cellular plasticity through an open discussion among the panelists and the audience. Particular topics will include: 1) What is dedifferentiation?; 2) What is transdifferentiation?; 3) Are more specific terms required to describe plasticity pathways?; and 4) What are the implications of terms such as metaplasia?
Speaker 3 of 3
Jason C. Mills, Washington University, USA

Wednesday, January 30 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, January 30 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Wednesday, January 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Wednesday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 30 | 5:00PM - 7:00PM
Transcriptional Regulation of Cell Plasticity
Room: Grays Peak

Speaker 1 of 5
* Janel Kopp, University of British Columbia, Canada

Wednesday, January 30 | 5:00PM - 7:00PM
Transcriptional Regulation of Cell Plasticity
Room: Grays Peak

Speaker 2 of 5
Ramesh A. Shivdasani, Dana-Farber Cancer Institute, USA
Epigenetic Regulation of Gut Development and Plasticity

Wednesday, January 30 | 5:00PM - 7:00PM
Transcriptional Regulation of Cell Plasticity
Room: Grays Peak

Speaker 3 of 5
Scott T. Magness, University of North Carolina at Chapel Hill, USA
Sox9 Regulates Reserve Intestinal Stem Cell Function

Wednesday, January 30 | 5:00PM - 7:00PM
Transcriptional Regulation of Cell Plasticity
Room: Grays Peak

Speaker 4 of 5
Michele A. Battle, Medical College of Wisconsin, USA
Transcriptional Regulation of Barrett’s Metaplasia

Wednesday, January 30 | 5:00PM - 7:00PM
Transcriptional Regulation of Cell Plasticity
Room: Grays Peak

Speaker 5 of 5
William Zacharias, Cincinnati Children's Hospital, USA
Short Talk: Defining the Gene Regulatory Networks Underlying Regenerative Capacity in Alveolar Epithelial Progenitor Cells

Wednesday, January 30 | 5:00PM - 7:00PM
Cell Competition and Mechanical Interactions
This session is from Developmental Signaling
Room: Longs Peak

Speaker 1 of 6
* Tadanori Mammoto, Medical College of Wisconsin, USA


Wednesday, January 30 | 5:00PM - 7:00PM
Cell Competition and Mechanical Interactions
This session is from Developmental Signaling
Room: Longs Peak

Speaker 2 of 6
Eugenia Piddini, University of Bristol, UK
Mechanical Cell Competition: Mechanisms and Implications for Epithelial Biology


Wednesday, January 30 | 5:00PM - 7:00PM
Cell Competition and Mechanical Interactions
This session is from Developmental Signaling
Room: Longs Peak

Speaker 3 of 6
Miguel Torres, Centro Nacional de Investigaciones Cardiovasculares, Spain
Cell Competition in Mammalian Development and Tissue Homeostasis


Wednesday, January 30 | 5:00PM - 7:00PM
Cell Competition and Mechanical Interactions
This session is from Developmental Signaling
Room: Longs Peak

Speaker 4 of 6
Nicolas Tapon, Francis Crick Institute, UK
Growth Control and Hippo Signaling in the Drosophila Abdomen


Wednesday, January 30 | 5:00PM - 7:00PM
Cell Competition and Mechanical Interactions
This session is from Developmental Signaling
Room: Longs Peak

Speaker 5 of 6
Giulia Pilia, Uppsala Universitet, Sweden
Short Talk: Ack1 Is a Mechanoresponsive Kinase Required for Regulation of Yap/Taz


Wednesday, January 30 | 5:00PM - 7:00PM
Cell Competition and Mechanical Interactions
This session is from Developmental Signaling
Room: Longs Peak

Speaker 6 of 6
Anne-Marie Pret, University of Versailles St Quentin-en-Yvelines, France
Short Talk: JAK/STAT Signaling and Epithelial Homeostasis in Drosophila


Wednesday, January 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Wednesday, January 30 | 7:30PM - 10:00PM
Poster Session 3
Room: Red Cloud/Shavano/Torreys


Thursday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Thursday, January 31 | 8:00AM - 11:00AM
Injury, Inflammation and Regeneration
Room: Grays Peak

Speaker 1 of 8
* Leonard H. Augenlicht, Albert Einstein College of Medicine, USA

Thursday, January 31 | 8:00AM - 11:00AM
Injury, Inflammation and Regeneration
Room: Grays Peak

Speaker 2 of 8
Irene Miguel-Aliaga, Imperial College London, UK
Sex Differences in Organ Plasticity

Thursday, January 31 | 8:00AM - 11:00AM
Injury, Inflammation and Regeneration
Room: Grays Peak

Speaker 3 of 8
Xin Sun, University of California, San Diego, USA
Neural-Immune Niches in the Airway

Thursday, January 31 | 8:00AM - 11:00AM
Injury, Inflammation and Regeneration
Room: Grays Peak


Coffee Break

Thursday, January 31 | 8:00AM - 11:00AM
Injury, Inflammation and Regeneration
Room: Grays Peak

Speaker 5 of 8
Juanita L. Merchant, University of Arizona College of Medicine, USA
How Do Immune Cells Reprogram the Epithelium?

Thursday, January 31 | 8:00AM - 11:00AM
Injury, Inflammation and Regeneration
Room: Grays Peak

Speaker 6 of 8
Anil K. Rustgi, University of Pennsylvania, USA
Metaplasia in Esophagus and Pancreas

Thursday, January 31 | 8:00AM - 11:00AM
Injury, Inflammation and Regeneration
Room: Grays Peak

Speaker 7 of 8
Peter J. Dempsey, University of Colorado Denver, USA
Short Talk: Cellular Plasticity of Defa4-Cre-Expressing Paneth Cells

Thursday, January 31 | 8:00AM - 11:00AM
Injury, Inflammation and Regeneration
Room: Grays Peak

Speaker 8 of 8
Won Jae Huh, Vanderbilt University Medical Center, USA
Short Talk: Transforming Growth Factor-a (TGFa) Overexpression Induces Spasmolytic Polypeptide Expressing Metaplasia

Thursday, January 31 | 8:00AM - 11:00AM
Developmental Signaling and Disease
This session is from Developmental Signaling
Room: Longs Peak

Speaker 1 of 8
* Thijs Jasper Hagenbeek, Genentech, Inc., USA


Thursday, January 31 | 8:00AM - 11:00AM
Developmental Signaling and Disease
This session is from Developmental Signaling
Room: Longs Peak

Speaker 2 of 8
Adolfo Ferrando, Columbia University, USA
Notch in T-Cell Acute Lymphoblastic Leukemia


Thursday, January 31 | 8:00AM - 11:00AM
Developmental Signaling and Disease
This session is from Developmental Signaling
Room: Longs Peak

Speaker 3 of 8
Feng Cong, Novartis Institutes for BioMedical Research, USA
Drug Discovery for the Wnt, TGFß/BMP, and HIPPO Pathways


Thursday, January 31 | 8:00AM - 11:00AM
Developmental Signaling and Disease
This session is from Developmental Signaling
Room: Longs Peak


Coffee Break


Thursday, January 31 | 8:00AM - 11:00AM
Developmental Signaling and Disease
This session is from Developmental Signaling
Room: Longs Peak

Speaker 5 of 8
Kun-Liang Guan, University of California, San Diego, USA
Hippo Signaling in Cancer


Thursday, January 31 | 8:00AM - 11:00AM
Developmental Signaling and Disease
This session is from Developmental Signaling
Room: Longs Peak

Speaker 6 of 8
Vincent Idone, Regeneron Pharmaceuticals Inc., USA
Activin Ligand Traps in Bone Disease Treatment


Thursday, January 31 | 8:00AM - 11:00AM
Developmental Signaling and Disease
This session is from Developmental Signaling
Room: Longs Peak

Speaker 7 of 8
Zlatko Trajanoski, Medical University of Innsbruck, Austria
Short Talk: Perturbation Biology of Colorectal Cancer Organoids Reveals Patient-Specific Signaling Rewiring and Interference with Immunity


Thursday, January 31 | 8:00AM - 11:00AM
Developmental Signaling and Disease
This session is from Developmental Signaling
Room: Longs Peak

Speaker 8 of 8
Dominique Celeste Mitchell, University of California, San Francisco, USA
Short Talk: Small Molecule Activation of LKB1 Reveals Multiphasic Hippo Pathway Signal Buffering


Thursday, January 31 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, January 31 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 31 | 5:00PM - 6:45PM
Applications of Cell Plasticity
Room: Grays Peak

Speaker 1 of 4
* Nicholas Zachos, Johns Hopkins University School of Medicine, USA

Thursday, January 31 | 5:00PM - 6:45PM
Applications of Cell Plasticity
Room: Grays Peak

Speaker 2 of 4
Joe Q. Zhou, Weill Cornell Medical College, USA
Making Insulin-Secreting Cells from Intestine

Thursday, January 31 | 5:00PM - 6:45PM
Applications of Cell Plasticity
Room: Grays Peak

Speaker 3 of 4
Darrell N. Kotton, Boston University, USA
Pluripotent Stem Cell Models of Lung Development and Disease

Thursday, January 31 | 5:00PM - 6:45PM
Applications of Cell Plasticity
Room: Grays Peak

Speaker 4 of 4
Wendy M. McKimpson, Columbia University, USA
Short Talk: Foxo1-Expressing Cells in the Gut as a Source of Insulin for Diabetes Treatment

Thursday, January 31 | 5:00PM - 6:45PM
Integration of Developmental Signaling Pathways
This session is from Developmental Signaling
Room: Longs Peak

Speaker 1 of 5
* Raphael Kopan, University of Cincinnati College of Medicine, USA


Thursday, January 31 | 5:00PM - 6:45PM
Integration of Developmental Signaling Pathways
This session is from Developmental Signaling
Room: Longs Peak

Speaker 2 of 5
Liliana Attisano, University of Toronto, Canada
NUAK2, a Feed Forward Regulator of the Hippo Pathway during Tumorigenesis


Thursday, January 31 | 5:00PM - 6:45PM
Integration of Developmental Signaling Pathways
This session is from Developmental Signaling
Room: Longs Peak

Speaker 3 of 5
Norbert Perrimon, Harvard Medical School, USA
Insights on the Role of Ion Channels in the Drosophila Gut Epithelium


Thursday, January 31 | 5:00PM - 6:45PM
Integration of Developmental Signaling Pathways
This session is from Developmental Signaling
Room: Longs Peak

Speaker 4 of 5
Lukasz Bugaj, University of Pennsylvania, USA
High-Throughput Multicolor Optogenetics for the Systematic Dissection of Signal Dynamics and Integration


Thursday, January 31 | 5:00PM - 6:45PM
Integration of Developmental Signaling Pathways
This session is from Developmental Signaling
Room: Longs Peak

Speaker 5 of 5
Andrei V. Karginov, University of Illinois at Chicago, USA
Short Talk: Interrogation of Signaling Pathways using Light-Regulated Protein Kinases


Thursday, January 31 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Grays Peak


Thursday, January 31 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Developmental Signaling
Room: Longs Peak


Thursday, January 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Thursday, January 31 | 8:00PM - 11:00PM
Entertainment
Room: Red Cloud/Shavano/Torreys
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 31 | 8:00PM - 11:00PM
Cash Bar
Room: Red Cloud/Shavano/Torreys


Friday, February 01 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.