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Web Desc
Signal Dynamics and Signal Integration in Development and Disease joint with Cellular Plasticity: Reprogramming, Regeneration and Metaplasia Organizer(s): Nicolas Tapon, Liliana Attisano and Raphael Kopan Date: January 27 - 31, 2019 Location: Keystone Resort, Keystone, CO, USA Supported by the Directors' Fund Summary of Meeting: The discovery and study of the major developmental signaling pathways (Notch, Hh, Wnt, RTK) has illuminated how patterning and growth are controlled in metazoans. These pathways are reiteratively used during development and adult life, acting to maintain stem cells and direct tissue repair and regeneration. When they are disrupted, cancer develops. This conference embraces recent progress in quantitative biology, mathematical modelling, single cell analysis and intravital imaging. It also presents a major opportunity to bring together knowledge from developmental systems with adult homeostasis, regeneration and cancer, as well as to elucidate how different developmental signals are integrated to influence cellular decision-making processes. The pairing with the conference on Cellular Plasticity: Reprogramming, Regeneration, and Metaplasia enables an in-depth exploration of the parallels between plasticity/pluripotency in development, regeneration and disease. In summary, the conference aims to: 1) Explore the commonalities between signaling in development, regeneration, and homeostasis, 2) Leverage quantitative, single cell and systems biology to study the dynamics and integration of developmental signaling across scales, and 3) Highlight how perturbations in developmental pathways cause diseases such as cancer. Scholarship Deadline: October 17 2018 Discounted Abstract Deadline: October 17 2018 Abstract Deadline: October 25 2018 Discounted Registration Deadline: November 28 2018 We gratefully acknowledge the generous grant for this conference provided by: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Grant No. 1 R13 HD096834-01 Funding for this conference was made possible (in part) by 1 R13 HD096834-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Signal Dynamics and Signal Integration in Development and Disease

joint with Cellular Plasticity: Reprogramming, Regeneration and Metaplasia

Organizer(s): Nicolas Tapon, Liliana Attisano and Raphael Kopan

Date: January 27 - 31, 2019
Location: Keystone Resort, Keystone, CO, USA

Supported by the Directors' Fund

Summary of Meeting:

The discovery and study of the major developmental signaling pathways (Notch, Hh, Wnt, RTK) has illuminated how patterning and growth are controlled in metazoans. These pathways are reiteratively used during development and adult life, acting to maintain stem cells and direct tissue repair and regeneration. When they are disrupted, cancer develops. This conference embraces recent progress in quantitative biology, mathematical modelling, single cell analysis and intravital imaging. It also presents a major opportunity to bring together knowledge from developmental systems with adult homeostasis, regeneration and cancer, as well as to elucidate how different developmental signals are integrated to influence cellular decision-making processes. The pairing with the conference on Cellular Plasticity: Reprogramming, Regeneration, and Metaplasia enables an in-depth exploration of the parallels between plasticity/pluripotency in development, regeneration and disease. In summary, the conference aims to: 1) Explore the commonalities between signaling in development, regeneration, and homeostasis, 2) Leverage quantitative, single cell and systems biology to study the dynamics and integration of developmental signaling across scales, and 3) Highlight how perturbations in developmental pathways cause diseases such as cancer.

Scholarship Deadline: October 17 2018

Discounted Abstract Deadline: October 17 2018

Abstract Deadline: October 25 2018

Discounted Registration Deadline: November 28 2018

We gratefully acknowledge the generous grant for this conference provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Grant No. 1 R13 HD096834-01
Funding for this conference was made possible (in part) by 1 R13 HD096834-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, January 27 \| 4:00PM - 8:00PM Arrival and Registration Room: Longs Peak Foyer
Sunday, January 27 \| 6:00PM - 8:00PM Welcome Mixer Room: Longs Peak Foyer No registration fees are used to fund alcohol served at this function.
Monday, January 28 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Monday, January 28 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Grays/Longs Peak Speaker 1 of 3 * Jason C. Mills, Washington University, USA
Monday, January 28 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Grays/Longs Peak Speaker 2 of 3 * Nicolas Tapon, Francis Crick Institute, UK
Monday, January 28 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Grays/Longs Peak Speaker 3 of 3 Hans C. Clevers, Hubrecht Institute, Netherlands Lgr5 Stem Cell-Based Organoids in Human Disease
Monday, January 28 \| 9:00AM - 11:30AM Plasticity and Signaling in Development and Homeostasis (Joi nt) Room: Grays/Longs Peak Speaker 1 of 8 * Anna Mae Diehl, Duke University, USA
Monday, January 28 \| 9:00AM - 11:30AM Plasticity and Signaling in Development and Homeostasis (Joi nt) Room: Grays/Longs Peak Speaker 2 of 8 * Michael B. O'Connor, University of Minnesota, Twin Cities, USA
Monday, January 28 \| 9:00AM - 11:30AM Plasticity and Signaling in Development and Homeostasis (Joi nt) Room: Grays/Longs Peak Speaker 3 of 8 Jayaraj Rajagopal, Massachusetts General Hospital, USA The Airway Epithelial Ensemble
Monday, January 28 \| 9:00AM - 11:30AM Plasticity and Signaling in Development and Homeostasis (Joi nt) Room: Grays/Longs Peak Coffee Break
Monday, January 28 \| 9:00AM - 11:30AM Plasticity and Signaling in Development and Homeostasis (Joi nt) Room: Grays/Longs Peak Speaker 5 of 8 Ophir Klein, University of California, San Francisco, USA Renewal and Plasticity in Oral Epithelia
Monday, January 28 \| 9:00AM - 11:30AM Plasticity and Signaling in Development and Homeostasis (Joi nt) Room: Grays/Longs Peak Speaker 6 of 8 Valentina Greco, Yale School of Medicine, USA Principles of Tissue Dynamics and Function Captured by Live Imaging
Monday, January 28 \| 9:00AM - 11:30AM Plasticity and Signaling in Development and Homeostasis (Joi nt) Room: Grays/Longs Peak Speaker 7 of 8 Erin N. Sanders, Stanford University, USA Short Talk: Real-Time Kinetics of Notch-Mediated Fate Decisions during Organ Renewal
Monday, January 28 \| 9:00AM - 11:30AM Plasticity and Signaling in Development and Homeostasis (Joi nt) Room: Grays/Longs Peak Speaker 8 of 8 Shiyan Yu, Rutgers University-Newark, USA Short Talk: Injury Induces Paneth Cell Plasticity
Monday, January 28 \| 11:15AM - 5:00PM On Own for Lunch
Monday, January 28 \| 11:15AM - 1:00PM Poster Setup Room: Red Cloud/Shavano/Torreys
Monday, January 28 \| 11:30AM - 12:30PM Meet the Editors (Joint) Room: Grays/Longs Peak Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science? Speaker 1 of 7 * Daniel Klimmeck, EMBO Journal, Germany
Monday, January 28 \| 11:30AM - 12:30PM Meet the Editors (Joint) Room: Grays/Longs Peak Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science? Speaker 2 of 7 * Sheila Chari, Cell Press, USA
Monday, January 28 \| 11:30AM - 12:30PM Meet the Editors (Joint) Room: Grays/Longs Peak Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science? Speaker 3 of 7 Iain Dickson, Nature Reviews, UK
Monday, January 28 \| 11:30AM - 12:30PM Meet the Editors (Joint) Room: Grays/Longs Peak Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science? Speaker 4 of 7 John F. Foley, Science Signaling, USA
Monday, January 28 \| 11:30AM - 12:30PM Meet the Editors (Joint) Room: Grays/Longs Peak Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science? Speaker 5 of 7 Seema Grewal, Development, UK
Monday, January 28 \| 11:30AM - 12:30PM Meet the Editors (Joint) Room: Grays/Longs Peak Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science? Speaker 6 of 7 Marie Bao, Cell Press, USA
Monday, January 28 \| 11:30AM - 12:30PM Meet the Editors (Joint) Room: Grays/Longs Peak Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science? Speaker 7 of 7 Jessie Ann Le Good, Nature Communications, UK
Monday, January 28 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano/Torreys
Monday, January 28 \| 2:30PM - 4:30PM Workshop Room: Longs Peak Speaker 1 of 6 * Silvia Santos, Francis Crick Institute, UK
Monday, January 28 \| 2:30PM - 4:30PM Workshop Room: Longs Peak Speaker 2 of 6 Julie B. Sneddon, University California, San Francisco, USA Cell Fate Determination in Human Pancreatic Endocrine Development
Monday, January 28 \| 2:30PM - 4:30PM Workshop Room: Longs Peak Speaker 3 of 6 Micha Sam Brickman Raredon, Yale University, USA Cross-Species scRNAseq Analysis of Cell-Cell Connectomics in Lung
Monday, January 28 \| 2:30PM - 4:30PM Workshop Room: Longs Peak Speaker 4 of 6 Jarod Zepp, University of Pennsylvania, USA Epithelial to Mesenchymal Crosstalk during the Postnatal Phase of Lung Development Coordinates Lineage Commitment and Niche Formation
Monday, January 28 \| 2:30PM - 4:30PM Workshop Room: Longs Peak Speaker 5 of 6 Oliver Wessely, Cleveland Clinic Foundation, USA A Design-of-Experiment Approach Towards Differentiation of Human Pluripotent Stem Cells into Definitive Kidney Cell Lineages
Monday, January 28 \| 2:30PM - 4:30PM Workshop Room: Longs Peak Speaker 6 of 6 Akiko Mammoto, Medical College of Wisconsin, USA Effects of Age-Dependent Changes in Cell Size on Endothelial Cell Growth through YAP1
Monday, January 28 \| 2:30PM - 4:30PM Workshop This session is from Cellular Plasticity Room: Grays Peak Speaker 1 of 8 * Chay T. Kuo, Duke University School of Medicine, USA
Monday, January 28 \| 2:30PM - 4:30PM Workshop This session is from Cellular Plasticity Room: Grays Peak Speaker 2 of 8 Lorin Olson, Oklahoma Medical Research Foundation, USA Mosaic Mutant Analysis Identifies PDGFRa/PDGFRb as Regulators of Adipocyte Progenitor Cell Plasticity
Monday, January 28 \| 2:30PM - 4:30PM Workshop This session is from Cellular Plasticity Room: Grays Peak Speaker 3 of 8 Feng Chen, University of California, San Francisco, USA Resolving the Contribution of Adult Liver Stem/Progenitor Cells to Hepatocyte Regeneration with a Dual AAV Vector System for Inducing Liver Injury and Lineage Tracing
Monday, January 28 \| 2:30PM - 4:30PM Workshop This session is from Cellular Plasticity Room: Grays Peak Speaker 4 of 8 Kenji Ito, University of Tokyo, Japan Cancer Drug Screening Based on Refractoriness of Cancer Cell Reprogramming
Monday, January 28 \| 2:30PM - 4:30PM Workshop This session is from Cellular Plasticity Room: Grays Peak Speaker 5 of 8 Enric Llorens-Bobadilla, Karolinska Institute, Sweden Programming Future Fate Decisions in the Glial Scar to Promote Spinal Cord Injury Repair
Monday, January 28 \| 2:30PM - 4:30PM Workshop This session is from Cellular Plasticity Room: Grays Peak Speaker 6 of 8 Agnieszka B. Bialkowska, Stony Brook University, USA Krüppel-Like Factor 5 Plays an Important Role in Acinar-to-Ductal Metaplasia of the Pancreas
Monday, January 28 \| 2:30PM - 4:30PM Workshop This session is from Cellular Plasticity Room: Grays Peak Speaker 7 of 8 Oscar Pellon-Cardenas, Rutgers University, USA CDX2 Loss Disrupts the Differentiation-Proliferation Balance during Initiation and Progression of Intestinal Tumors
Monday, January 28 \| 2:30PM - 4:30PM Workshop This session is from Cellular Plasticity Room: Grays Peak Speaker 8 of 8 Lianghui Zhang, University of Illinois at Chicago, USA Differential Pathogen Response Mechanisms and Single Cell Heterogeneity in Endothelial Regeneration
Monday, January 28 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, January 28 \| 5:00PM - 7:00PM Quantitative Approaches and Signaling Networks Room: Longs Peak Speaker 1 of 6 * Anna Kicheva, Institute of Science and Technology Austria, Austria
Monday, January 28 \| 5:00PM - 7:00PM Quantitative Approaches and Signaling Networks Room: Longs Peak Speaker 2 of 6 Michael Elowitz, California Institute of Technology, USA Communication and Computation in Protein Circuits
Monday, January 28 \| 5:00PM - 7:00PM Quantitative Approaches and Signaling Networks Room: Longs Peak Speaker 3 of 6 Ertugrul M. Ozbudak, Cincinnati Children's Hospital Medical Center, USA Spatial Fold-Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish
Monday, January 28 \| 5:00PM - 7:00PM Quantitative Approaches and Signaling Networks Room: Longs Peak Speaker 4 of 6 Mary N. Teruel, Stanford University, USA Control of Cell Differentiation by Timing and Phase-Shifting of Physiological Oscillators
Monday, January 28 \| 5:00PM - 7:00PM Quantitative Approaches and Signaling Networks Room: Longs Peak Speaker 5 of 6 Jared Toettcher, Princeton University, USA Short Talk: Cellular Optogenetics Reveals Principles of Cell Fate Control in the Early Drosophila Embryo
Monday, January 28 \| 5:00PM - 7:00PM Quantitative Approaches and Signaling Networks Room: Longs Peak Speaker 6 of 6 Amanda L. Zacharias, Cincinnati Children's Hospital Medical Center, USA Short Talk: Comprehensive Quantitative Analysis of Nuclear ß-catenin in C. elegans Embryos Identifies a Novel Memory Mechanism for Gene Expression Diversification
Monday, January 28 \| 5:00PM - 7:00PM Stem Cell Recruitment and Metaplasia This session is from Cellular Plasticity Room: Grays Peak Speaker 1 of 5 * Eunyoung Choi, Vanderbilt University Medical Center, USA
Monday, January 28 \| 5:00PM - 7:00PM Stem Cell Recruitment and Metaplasia This session is from Cellular Plasticity Room: Grays Peak Speaker 2 of 5 Calvin Kuo, Stanford University, USA Intestinal Stem Cell Niches
Monday, January 28 \| 5:00PM - 7:00PM Stem Cell Recruitment and Metaplasia This session is from Cellular Plasticity Room: Grays Peak Speaker 3 of 5 James R. Goldenring, Vanderbilt University Medical Center, USA Inflammatory Regulation of Metaplasia Induction in the Stomach
Monday, January 28 \| 5:00PM - 7:00PM Stem Cell Recruitment and Metaplasia This session is from Cellular Plasticity Room: Grays Peak Speaker 4 of 5 Jason C. Mills, Washington University, USA Reserve Stem Cells Recruited by Paligenosis, an Evolutionarily Conserved Program
Monday, January 28 \| 5:00PM - 7:00PM Stem Cell Recruitment and Metaplasia This session is from Cellular Plasticity Room: Grays Peak Speaker 5 of 5 Melissa Hirose Wong, Oregon Health & Science University, USA Short Talk: Macrophage-Cancer Stem Cell Fusion Underlies Cancer Cell Plasticity and Potentiates Metastatic Spread of Disease
Monday, January 28 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Monday, January 28 \| 7:30PM - 10:00PM Poster Session 1 Room: Red Cloud/Shavano/Torreys
Tuesday, January 29 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Tuesday, January 29 \| 8:00AM - 11:00AM Signaling Dynamics Room: Longs Peak Speaker 1 of 9 * Dan Shaye, University of Illinois at Chicago, USA
Tuesday, January 29 \| 8:00AM - 11:00AM Signaling Dynamics Room: Longs Peak Speaker 2 of 9 Vivian Li, Francis Crick Institute, UK Wnt Signal Rregulation in Intestinal Stem Cells and Cancer
Tuesday, January 29 \| 8:00AM - 11:00AM Signaling Dynamics Room: Longs Peak Speaker 3 of 9 Deborah L. Gumucio, University of Michigan, USA Dynamic Roles for WNT5a During Morphogenesis of the Mouse Fetal Intestine
Tuesday, January 29 \| 8:00AM - 11:00AM Signaling Dynamics Room: Longs Peak Coffee Break
Tuesday, January 29 \| 8:00AM - 11:00AM Signaling Dynamics Room: Longs Peak Speaker 5 of 9 Raphael Kopan, University of Cincinnati College of Medicine, USA A Role for Notch Dimerization and CSL Binding-Site Architecture in Mammalian Development and Tissue Maintenance
Tuesday, January 29 \| 8:00AM - 11:00AM Signaling Dynamics Room: Longs Peak Speaker 6 of 9 Victoria Ng, Vanderbilt University, USA Short Talk: The USP46 Complex Promotes Wnt Signaling by Blocking Receptor Turnover
Tuesday, January 29 \| 8:00AM - 11:00AM Signaling Dynamics Room: Longs Peak Speaker 7 of 9 Sergi Regot, Johns Hopkins University, USA Short Talk: Single Cell Analysis of MAPK Signaling Dynamics in Multicellular Systems
Tuesday, January 29 \| 8:00AM - 11:00AM Signaling Dynamics Room: Longs Peak Speaker 8 of 9 David Sprinzak, Tel Aviv University, Israel Short Talk: Localized Feedbacks on Fat4-Ds1 Complexes Underlie Planar Cell Polarity
Tuesday, January 29 \| 8:00AM - 11:00AM Signaling Dynamics Room: Longs Peak Speaker 9 of 9 Kaelyn Sumigray, Duke University School of Medicine, USA Short Talk: Morphogenesis and Compartmentalization of the Mammalian Intestine
Tuesday, January 29 \| 8:00AM - 11:15AM Cancer and Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 1 of 9 * Blair B. Madison, Washington University, USA
Tuesday, January 29 \| 8:00AM - 11:15AM Cancer and Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 2 of 9 Arjun Raj, University of Pennsylvania, USA Controlling Cellular Plasticity in Cancer
Tuesday, January 29 \| 8:00AM - 11:15AM Cancer and Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 3 of 9 Ben Z. Stanger, University of Pennsylvania, USA Epithelial-Mesenchymal Plasticity in Cancer Cell Invasion and Metastasis
Tuesday, January 29 \| 8:00AM - 11:15AM Cancer and Plasticity This session is from Cellular Plasticity Room: Grays Peak Coffee Break
Tuesday, January 29 \| 8:00AM - 11:15AM Cancer and Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 5 of 9 Carla F. Kim, Boston Children's Hospital, USA Regulation of Progenitor Cells in the Adult Lung
Tuesday, January 29 \| 8:00AM - 11:15AM Cancer and Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 6 of 9 Cory T. Abate-Shen, Columbia University Medical Center, USA Cellular Plasticity in Prostate Cancer
Tuesday, January 29 \| 8:00AM - 11:15AM Cancer and Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 7 of 9 Rohit Chandwani, Weill Cornell Medicine, USA Short Talk: Chromatin Dynamics in vivo Reveal the Complexity of Cell Fate Transitions in Pancreatic Cancer Initiation
Tuesday, January 29 \| 8:00AM - 11:15AM Cancer and Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 8 of 9 Ellen M. Langer, Oregon Health & Science University, USA Short Talk: The Prolyl Isomerase PIN1 Plays a Critical Role in Pancreatic Stellate Cell Plasticity to Impact Tumor Development
Tuesday, January 29 \| 8:00AM - 11:15AM Cancer and Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 9 of 9 Karuna Ganesh, Memorial Sloan Kettering Cancer Center, USA Short Talk: Regenerative Origin of Metastasis-Initiating Cells
Tuesday, January 29 \| 11:00AM - 5:00PM On Own for Lunch
Tuesday, January 29 \| 11:00AM - 1:00PM Poster Setup Room: Red Cloud/Shavano/Torreys
Tuesday, January 29 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano/Torreys
Tuesday, January 29 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, January 29 \| 5:00PM - 7:00PM Morphogen Gradients in Growth and Patterning Room: Longs Peak Speaker 1 of 6 * Kaelyn Sumigray, Duke University School of Medicine, USA
Tuesday, January 29 \| 5:00PM - 7:00PM Morphogen Gradients in Growth and Patterning Room: Longs Peak Speaker 2 of 6 Caroline S. Hill, Francis Crick Institute, UK Self-Organizing Pattern Formation in Endoderm Specification in Zebrafish
Tuesday, January 29 \| 5:00PM - 7:00PM Morphogen Gradients in Growth and Patterning Room: Longs Peak Speaker 3 of 6 Anna Kicheva, Institute of Science and Technology Austria, Austria Coordination of Progenitor Specification and Growth in the Developing Spinal Cord
Tuesday, January 29 \| 5:00PM - 7:00PM Morphogen Gradients in Growth and Patterning Room: Longs Peak Speaker 4 of 6 Jean-Paul B. Vincent, Francis Crick Institute, UK Coordination of Growth and Patterning in a Developing Epithelium
Tuesday, January 29 \| 5:00PM - 7:00PM Morphogen Gradients in Growth and Patterning Room: Longs Peak Speaker 5 of 6 Jennifer Kong, Stanford University, USA Short Talk: Molecular Mechanisms that Regulate Target Cell Sensitivity to Hedgehog Morphogens
Tuesday, January 29 \| 5:00PM - 7:00PM Morphogen Gradients in Growth and Patterning Room: Longs Peak Speaker 6 of 6 Shinji Takada, National Institute for Basic Biology, Japan Short Talk: Extracellular Dynamics and Diffusion Range of Wnt Protein Complex in Xenopus Embryos
Tuesday, January 29 \| 5:00PM - 7:00PM Reprogramming Cells to Assemble and Repair Organs This session is from Cellular Plasticity Room: Grays Peak Speaker 1 of 6 * Sydney Shaffer, University of Pennsylvania, USA
Tuesday, January 29 \| 5:00PM - 7:00PM Reprogramming Cells to Assemble and Repair Organs This session is from Cellular Plasticity Room: Grays Peak Speaker 2 of 6 Jason R. Spence, University of Michigan Health System, USA Intestinal Organoids
Tuesday, January 29 \| 5:00PM - 7:00PM Reprogramming Cells to Assemble and Repair Organs This session is from Cellular Plasticity Room: Grays Peak Speaker 3 of 6 Takanori Takebe, Cincinnati Children's Hospital Medical Center, Japan Next-Gen Organoids from Pluripotency
Tuesday, January 29 \| 5:00PM - 7:00PM Reprogramming Cells to Assemble and Repair Organs This session is from Cellular Plasticity Room: Grays Peak Speaker 4 of 6 Frederic J. de Sauvage, Genentech, Inc., USA Targeting Intestinal Stem Cells in Cancer
Tuesday, January 29 \| 5:00PM - 7:00PM Reprogramming Cells to Assemble and Repair Organs This session is from Cellular Plasticity Room: Grays Peak Speaker 5 of 6 Purushothama Rao Tata, Duke University School of Medicine, USA Short Talk: Stem Cells and Reserve Stem Cells in the Lung
Tuesday, January 29 \| 5:00PM - 7:00PM Reprogramming Cells to Assemble and Repair Organs This session is from Cellular Plasticity Room: Grays Peak Speaker 6 of 6 Qiong Wang, City of Hope/BRI, USA Short Talk: Reversible Dedifferentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation
Tuesday, January 29 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Tuesday, January 29 \| 7:30PM - 10:00PM Poster Session 2 Room: Red Cloud/Shavano/Torreys
Wednesday, January 30 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Wednesday, January 30 \| 8:00AM - 11:00AM Plasticity and Signaling in Regeneration and Tumorigenesis ( Joint) Room: Grays/Longs Peak Speaker 1 of 9 * Caroline S. Hill, Francis Crick Institute, UK
Wednesday, January 30 \| 8:00AM - 11:00AM Plasticity and Signaling in Regeneration and Tumorigenesis ( Joint) Room: Grays/Longs Peak Speaker 2 of 9 * Thea D. Tlsty, University of California, San Francisco, USA
Wednesday, January 30 \| 8:00AM - 11:00AM Plasticity and Signaling in Regeneration and Tumorigenesis ( Joint) Room: Grays/Longs Peak Speaker 3 of 9 Jeffrey L. Wrana, Mount Sinai Hospital, Canada Revival Stem Cells Regenerate the Intestine
Wednesday, January 30 \| 8:00AM - 11:00AM Plasticity and Signaling in Regeneration and Tumorigenesis ( Joint) Room: Grays/Longs Peak Speaker 4 of 9 Maike Sander, University of California, San Diego, USA Deconstructing Endodermal Organ Development to Reconstruct Organs From Stem Cells
Wednesday, January 30 \| 8:00AM - 11:00AM Plasticity and Signaling in Regeneration and Tumorigenesis ( Joint) Room: Grays/Longs Peak Coffee Break
Wednesday, January 30 \| 8:00AM - 11:00AM Plasticity and Signaling in Regeneration and Tumorigenesis ( Joint) Room: Grays/Longs Peak Speaker 6 of 9 Stacey S. Huppert, Cincinnati Children’s Hospital Medical Center, USA Building a Functional Biliary System via Hepatocyte Plasticity
Wednesday, January 30 \| 8:00AM - 11:00AM Plasticity and Signaling in Regeneration and Tumorigenesis ( Joint) Room: Grays/Longs Peak Speaker 7 of 9 Owen J. Sansom, Beatson Institute of Cancer Research, UK Reserve Stem Cells and Intestinal Tumorigenesis: Foetal Progenitors and Microbiome in Colorectal Cancer
Wednesday, January 30 \| 8:00AM - 11:00AM Plasticity and Signaling in Regeneration and Tumorigenesis ( Joint) Room: Grays/Longs Peak Speaker 8 of 9 Margaret E. Magaletta, University of Massachusetts Medical School, USA Short Talk: Single Cell Transcriptomic Analysis Resolves Dynamics of Developing Pharyngeal Endoderm
Wednesday, January 30 \| 8:00AM - 11:00AM Plasticity and Signaling in Regeneration and Tumorigenesis ( Joint) Room: Grays/Longs Peak Speaker 9 of 9 P. Duc Si Dong, Sanford Burnham Prebys Medical Discovery Institute, USA Short Talk: Biliary Paucity Due Jagged/Notch Loss is Reversible via a Novel Non-Hepatic Multipotent Cell Population
Wednesday, January 30 \| 11:00AM - 12:00PM Panel: Nomenclature in Cell Plasticity: 'Plasticity,' 'Dedif ferentiation,' 'Transdifferentiation,' 'Reprogramming,' 'Reversion,' 'Paligenosis' - Can We Agree What These Mean? This session is from Cellular Plasticity Room: Grays/Longs Peak This session will seek to examine the utility of critical terms relating to cellular plasticity through an open discussion among the panelists and the audience. Particular topics will include: 1) What is dedifferentiation?; 2) What is transdifferentiation?; 3) Are more specific terms required to describe plasticity pathways?; and 4) What are the implications of terms such as metaplasia? Speaker 1 of 3 James R. Goldenring, Vanderbilt University Medical Center, USA
Wednesday, January 30 \| 11:00AM - 12:00PM Panel: Nomenclature in Cell Plasticity: 'Plasticity,' 'Dedif ferentiation,' 'Transdifferentiation,' 'Reprogramming,' 'Reversion,' 'Paligenosis' - Can We Agree What These Mean? This session is from Cellular Plasticity Room: Grays/Longs Peak This session will seek to examine the utility of critical terms relating to cellular plasticity through an open discussion among the panelists and the audience. Particular topics will include: 1) What is dedifferentiation?; 2) What is transdifferentiation?; 3) Are more specific terms required to describe plasticity pathways?; and 4) What are the implications of terms such as metaplasia? Speaker 2 of 3 Anna Mae Diehl, Duke University, USA
Wednesday, January 30 \| 11:00AM - 12:00PM Panel: Nomenclature in Cell Plasticity: 'Plasticity,' 'Dedif ferentiation,' 'Transdifferentiation,' 'Reprogramming,' 'Reversion,' 'Paligenosis' - Can We Agree What These Mean? This session is from Cellular Plasticity Room: Grays/Longs Peak This session will seek to examine the utility of critical terms relating to cellular plasticity through an open discussion among the panelists and the audience. Particular topics will include: 1) What is dedifferentiation?; 2) What is transdifferentiation?; 3) Are more specific terms required to describe plasticity pathways?; and 4) What are the implications of terms such as metaplasia? Speaker 3 of 3 Jason C. Mills, Washington University, USA
Wednesday, January 30 \| 11:00AM - 5:00PM On Own for Lunch
Wednesday, January 30 \| 11:00AM - 1:00PM Poster Setup Room: Red Cloud/Shavano/Torreys
Wednesday, January 30 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano/Torreys
Wednesday, January 30 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, January 30 \| 5:00PM - 7:00PM Cell Competition and Mechanical Interactions Room: Longs Peak Speaker 1 of 6 * Tadanori Mammoto, Medical College of Wisconsin, USA
Wednesday, January 30 \| 5:00PM - 7:00PM Cell Competition and Mechanical Interactions Room: Longs Peak Speaker 2 of 6 Eugenia Piddini, University of Bristol, UK Mechanical Cell Competition: Mechanisms and Implications for Epithelial Biology
Wednesday, January 30 \| 5:00PM - 7:00PM Cell Competition and Mechanical Interactions Room: Longs Peak Speaker 3 of 6 Miguel Torres, Centro Nacional de Investigaciones Cardiovasculares, Spain Cell Competition in Mammalian Development and Tissue Homeostasis
Wednesday, January 30 \| 5:00PM - 7:00PM Cell Competition and Mechanical Interactions Room: Longs Peak Speaker 4 of 6 Nicolas Tapon, Francis Crick Institute, UK Growth Control and Hippo Signaling in the Drosophila Abdomen
Wednesday, January 30 \| 5:00PM - 7:00PM Cell Competition and Mechanical Interactions Room: Longs Peak Speaker 5 of 6 Giulia Pilia, Uppsala Universitet, Sweden Short Talk: Ack1 Is a Mechanoresponsive Kinase Required for Regulation of Yap/Taz
Wednesday, January 30 \| 5:00PM - 7:00PM Cell Competition and Mechanical Interactions Room: Longs Peak Speaker 6 of 6 Anne-Marie Pret, University of Versailles St Quentin-en-Yvelines, France Short Talk: JAK/STAT Signaling and Epithelial Homeostasis in Drosophila
Wednesday, January 30 \| 5:00PM - 7:00PM Transcriptional Regulation of Cell Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 1 of 5 * Janel Kopp, University of British Columbia, Canada
Wednesday, January 30 \| 5:00PM - 7:00PM Transcriptional Regulation of Cell Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 2 of 5 Ramesh A. Shivdasani, Dana-Farber Cancer Institute, USA Epigenetic Regulation of Gut Development and Plasticity
Wednesday, January 30 \| 5:00PM - 7:00PM Transcriptional Regulation of Cell Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 3 of 5 Scott T. Magness, University of North Carolina at Chapel Hill, USA Sox9 Regulates Reserve Intestinal Stem Cell Function
Wednesday, January 30 \| 5:00PM - 7:00PM Transcriptional Regulation of Cell Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 4 of 5 Michele A. Battle, Medical College of Wisconsin, USA Transcriptional Regulation of Barrett’s Metaplasia
Wednesday, January 30 \| 5:00PM - 7:00PM Transcriptional Regulation of Cell Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 5 of 5 William Zacharias, Cincinnati Children's Hospital, USA Short Talk: Defining the Gene Regulatory Networks Underlying Regenerative Capacity in Alveolar Epithelial Progenitor Cells
Wednesday, January 30 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Wednesday, January 30 \| 7:30PM - 10:00PM Poster Session 3 Room: Red Cloud/Shavano/Torreys
Thursday, January 31 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Thursday, January 31 \| 8:00AM - 11:00AM Developmental Signaling and Disease Room: Longs Peak Speaker 1 of 8 * Thijs Jasper Hagenbeek, Genentech, Inc., USA
Thursday, January 31 \| 8:00AM - 11:00AM Developmental Signaling and Disease Room: Longs Peak Speaker 2 of 8 Adolfo Ferrando, Columbia University, USA Notch in T-Cell Acute Lymphoblastic Leukemia
Thursday, January 31 \| 8:00AM - 11:00AM Developmental Signaling and Disease Room: Longs Peak Speaker 3 of 8 Feng Cong, Novartis Institutes for BioMedical Research, USA Drug Discovery for the Wnt, TGFß/BMP, and HIPPO Pathways
Thursday, January 31 \| 8:00AM - 11:00AM Developmental Signaling and Disease Room: Longs Peak Coffee Break
Thursday, January 31 \| 8:00AM - 11:00AM Developmental Signaling and Disease Room: Longs Peak Speaker 5 of 8 Kun-Liang Guan, University of California, San Diego, USA Hippo Signaling in Cancer
Thursday, January 31 \| 8:00AM - 11:00AM Developmental Signaling and Disease Room: Longs Peak Speaker 6 of 8 Vincent Idone, Regeneron Pharmaceuticals Inc., USA Activin Ligand Traps in Bone Disease Treatment
Thursday, January 31 \| 8:00AM - 11:00AM Developmental Signaling and Disease Room: Longs Peak Speaker 7 of 8 Zlatko Trajanoski, Medical University of Innsbruck, Austria Short Talk: Perturbation Biology of Colorectal Cancer Organoids Reveals Patient-Specific Signaling Rewiring and Interference with Immunity
Thursday, January 31 \| 8:00AM - 11:00AM Developmental Signaling and Disease Room: Longs Peak Speaker 8 of 8 Dominique Celeste Mitchell, University of California, San Francisco, USA Short Talk: Small Molecule Activation of LKB1 Reveals Multiphasic Hippo Pathway Signal Buffering
Thursday, January 31 \| 8:00AM - 11:00AM Injury, Inflammation and Regeneration This session is from Cellular Plasticity Room: Grays Peak Speaker 1 of 8 * Leonard H. Augenlicht, Albert Einstein College of Medicine, USA
Thursday, January 31 \| 8:00AM - 11:00AM Injury, Inflammation and Regeneration This session is from Cellular Plasticity Room: Grays Peak Speaker 2 of 8 Irene Miguel-Aliaga, Imperial College London, UK Sex Differences in Organ Plasticity
Thursday, January 31 \| 8:00AM - 11:00AM Injury, Inflammation and Regeneration This session is from Cellular Plasticity Room: Grays Peak Speaker 3 of 8 Xin Sun, University of California, San Diego, USA Neural-Immune Niches in the Airway
Thursday, January 31 \| 8:00AM - 11:00AM Injury, Inflammation and Regeneration This session is from Cellular Plasticity Room: Grays Peak Coffee Break
Thursday, January 31 \| 8:00AM - 11:00AM Injury, Inflammation and Regeneration This session is from Cellular Plasticity Room: Grays Peak Speaker 5 of 8 Juanita L. Merchant, University of Arizona College of Medicine, USA How Do Immune Cells Reprogram the Epithelium?
Thursday, January 31 \| 8:00AM - 11:00AM Injury, Inflammation and Regeneration This session is from Cellular Plasticity Room: Grays Peak Speaker 6 of 8 Anil K. Rustgi, University of Pennsylvania, USA Metaplasia in Esophagus and Pancreas
Thursday, January 31 \| 8:00AM - 11:00AM Injury, Inflammation and Regeneration This session is from Cellular Plasticity Room: Grays Peak Speaker 7 of 8 Peter J. Dempsey, University of Colorado Denver, USA Short Talk: Cellular Plasticity of Defa4-Cre-Expressing Paneth Cells
Thursday, January 31 \| 8:00AM - 11:00AM Injury, Inflammation and Regeneration This session is from Cellular Plasticity Room: Grays Peak Speaker 8 of 8 Won Jae Huh, Vanderbilt University Medical Center, USA Short Talk: Transforming Growth Factor-a (TGFa) Overexpression Induces Spasmolytic Polypeptide Expressing Metaplasia
Thursday, January 31 \| 11:00AM - 5:00PM On Own for Lunch
Thursday, January 31 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, January 31 \| 5:00PM - 6:45PM Integration of Developmental Signaling Pathways Room: Longs Peak Speaker 1 of 5 * Raphael Kopan, University of Cincinnati College of Medicine, USA
Thursday, January 31 \| 5:00PM - 6:45PM Integration of Developmental Signaling Pathways Room: Longs Peak Speaker 2 of 5 Liliana Attisano, University of Toronto, Canada NUAK2, a Feed Forward Regulator of the Hippo Pathway during Tumorigenesis
Thursday, January 31 \| 5:00PM - 6:45PM Integration of Developmental Signaling Pathways Room: Longs Peak Speaker 3 of 5 Norbert Perrimon, Harvard Medical School, USA Insights on the Role of Ion Channels in the Drosophila Gut Epithelium
Thursday, January 31 \| 5:00PM - 6:45PM Integration of Developmental Signaling Pathways Room: Longs Peak Speaker 4 of 5 Lukasz Bugaj, University of Pennsylvania, USA High-Throughput Multicolor Optogenetics for the Systematic Dissection of Signal Dynamics and Integration
Thursday, January 31 \| 5:00PM - 6:45PM Integration of Developmental Signaling Pathways Room: Longs Peak Speaker 5 of 5 Andrei V. Karginov, University of Illinois at Chicago, USA Short Talk: Interrogation of Signaling Pathways using Light-Regulated Protein Kinases
Thursday, January 31 \| 5:00PM - 6:45PM Applications of Cell Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 1 of 4 * Nicholas Zachos, Johns Hopkins University School of Medicine, USA
Thursday, January 31 \| 5:00PM - 6:45PM Applications of Cell Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 2 of 4 Joe Q. Zhou, Weill Cornell Medical College, USA Making Insulin-Secreting Cells from Intestine
Thursday, January 31 \| 5:00PM - 6:45PM Applications of Cell Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 3 of 4 Darrell N. Kotton, Boston University, USA Pluripotent Stem Cell Models of Lung Development and Disease
Thursday, January 31 \| 5:00PM - 6:45PM Applications of Cell Plasticity This session is from Cellular Plasticity Room: Grays Peak Speaker 4 of 4 Wendy M. McKimpson, Columbia University, USA Short Talk: Foxo1-Expressing Cells in the Gut as a Source of Insulin for Diabetes Treatment
Thursday, January 31 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Longs Peak
Thursday, January 31 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) This session is from Cellular Plasticity Room: Grays Peak
Thursday, January 31 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Thursday, January 31 \| 8:00PM - 11:00PM Entertainment Room: Red Cloud/Shavano/Torreys Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, January 31 \| 8:00PM - 11:00PM Cash Bar Room: Red Cloud/Shavano/Torreys
Friday, February 01 \| 10:24AM - 10:24AM Departure *Session Chair.