Past Meeting | Keystone Symposia

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B Cell Renaissance: Epigenetics, Regulation and Immunotherapy (2020X1)

Web Desc
B Cell-T Cell Interactions joint with Molecular Approaches to Vaccines and Immune Monitoring Organizer(s): Gabriel D. Victora and Carola G. Vinuesa Date: February 10 - 14, 2019 Location: Keystone Resort, Keystone, CO, USA Sponsored by BioLegend, Inc. For important information on the coronavirus, please click here Summary of Meeting: B cell-T cell interactions bring about the maturation and production of high affinity antibodies and are key to the establishment of effective humoral immunity. While this greatly enhances our ability to fight pathogens, it also can lead to the development of allergies and autoimmune disease. While recent years have seen a burst in our understanding of how B cell-T cell interactions drive antibody affinity maturation, a number of gaps remain, including how these interactions influence the differentiation of B cells into effector fates and how they limit the emergence of autoreactive B cell clones. Most importantly, from the vaccine standpoint, it is likely that better understanding of how T cell help shapes the B cell repertoire will allow us to better control the specificity of vaccine-induced immune responses. The aim of this Keystone symposium will be to: (1) Present the most recent advances in the basic biology of the T cell-dependent B cell response, focusing on Tfh development and function and B cell activation and differentiation; (2) address the gap in our understanding the differentiation of B cells into post-activation (memory and plasma cell) fates; (3) discuss how furthering our understanding of B cell-T cell interactions can inform vaccine development; and (4) present recent findings regarding the role of T-cell dependent B cell response in allergy and autoimmunity. Scholarship Deadline: October 23 2018 Discounted Abstract Deadline: October 23 2018 Abstract Deadline: November 7 2018 Discounted Registration Deadline: December 6 2018 Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested. Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Viela Bio We gratefully acknowledge the generous grant for this conference provided by: National Institute of Allergy and Infectious Diseases (NIAID) Grant No. 1 R13 AI140576-01 Funding for this conference was made possible (in part) by 1 R13 AI140576-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

B Cell-T Cell Interactions

joint with Molecular Approaches to Vaccines and Immune Monitoring

Organizer(s): Gabriel D. Victora and Carola G. Vinuesa

Date: February 10 - 14, 2019
Location: Keystone Resort, Keystone, CO, USA

Program


Sunday, February 10 \| 4:00PM - 8:00PM Arrival and Registration Room: Longs Peak Foyer
Sunday, February 10 \| 6:00PM - 8:00PM Welcome Mixer Room: Longs Peak Foyer No registration fees are used to fund alcohol served at this function.
Monday, February 11 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Monday, February 11 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Columbine Ballroom Speaker 1 of 2 * Facundo D. Batista, Massachusetts Institute of Technology and Harvard University, USA
Monday, February 11 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Columbine Ballroom Speaker 2 of 2 Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland The B Cell Immune Response to Infection and Vaccination
Monday, February 11 \| 9:00AM - 9:30AM Coffee Break Room: Longs Peak Foyer
Monday, February 11 \| 9:30AM - 11:30AM Tfh Biology Room: Quandary Peak Speaker 1 of 5 Carola G. Vinuesa, Australian National University, Australia Human Tfh Biology
Monday, February 11 \| 9:30AM - 11:30AM Tfh Biology Room: Quandary Peak Speaker 2 of 5 Hai Qi, Tsinghua University, China Guidance Cues for Tfh Cells
Monday, February 11 \| 9:30AM - 11:30AM Tfh Biology Room: Quandary Peak Speaker 3 of 5 Shane Crotty, La Jolla Institute for Immunology, USA Tfh Cell and Germinal Center B Cell Responses in the Context of Infections and Vaccines
Monday, February 11 \| 9:30AM - 11:30AM Tfh Biology Room: Quandary Peak Speaker 4 of 5 * Pamela L. Schwartzberg, NIAID, NHGRI, National Institutes of Health, USA Short Talk: PI3 Kinase-Mediated Pathways Orchestrate T and B Cell Contributions to Humoral Responses during Immunization and Infection
Monday, February 11 \| 9:30AM - 11:30AM Tfh Biology Room: Quandary Peak Speaker 5 of 5 Stephanie C. Eisenbarth, Yale University, USA Short Talk: A Unique Subset of Tfh Cells Drives High-Affinity IgE Production
Monday, February 11 \| 9:30AM - 11:45AM Targeting Appropriate Immune Responses for Structure-Based D esign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 1 of 8 * Erica Ollmann Saphire, La Jolla Institute for Immunology, USA
Monday, February 11 \| 9:30AM - 11:45AM Targeting Appropriate Immune Responses for Structure-Based D esign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 2 of 8 * Gary J. Nabel, Sanofi, USA
Monday, February 11 \| 9:30AM - 11:45AM Targeting Appropriate Immune Responses for Structure-Based D esign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 3 of 8 Dennis R. Burton, The Scripps Research Institute, USA From Antibody to Vaccine
Monday, February 11 \| 9:30AM - 11:45AM Targeting Appropriate Immune Responses for Structure-Based D esign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 4 of 8 George Georgiou, University of Texas at Austin, USA Molecular Definition of Protective Serum Responses from Vaccination and for Immune Monitoring
Monday, February 11 \| 9:30AM - 11:45AM Targeting Appropriate Immune Responses for Structure-Based D esign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 5 of 8 Peter D. Kwong, NIAID, National Institutes of Health, USA Antibody-Guided Structure-Based Vaccines: Challenges and Opportunities
Monday, February 11 \| 9:30AM - 11:45AM Targeting Appropriate Immune Responses for Structure-Based D esign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 6 of 8 Evelien M. Bunnik, University of Texas Health Science Center, USA Short Talk: Naturally Acquired Protective Humoral Immunity Against Malaria
Monday, February 11 \| 9:30AM - 11:45AM Targeting Appropriate Immune Responses for Structure-Based D esign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 7 of 8 Nisreen Mamdouh Ahmed Okba, Erasmus MC, Netherlands Short Talk: Antibody Responses as Blueprint for MERS-CoV Rational Vaccine Design
Monday, February 11 \| 9:30AM - 11:45AM Targeting Appropriate Immune Responses for Structure-Based D esign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 8 of 8 Andrew McGuire, Fred Hutchinson Cancer Research Center, USA Short Talk: An Anti-gH/gL Antibody that Neutralizes Dual-Tropic Infection Defines a Site of Vulnerability on Epstein-Barr Virus
Monday, February 11 \| 11:30AM - 5:00PM On Own for Lunch
Monday, February 11 \| 11:45AM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Monday, February 11 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Biology of B Cell-T Cell Interactions Room: Quandary Peak Speaker 1 of 8 * Dirk Baumjohann, Ludwig-Maximilians-University Munich, Germany T Cell-Expressed MicroRNAs Critically Regulate Germinal Center Tfh and B Cell Function and Maintenance
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Biology of B Cell-T Cell Interactions Room: Quandary Peak Speaker 2 of 8 Numana Bhat, Sanford Burnham Prebys Medical Discovery Institute, USA Regnase-1 Is Essential for Controlling Aberrant Differentiation of B Cells during Maturation and T Dependent B Cell Response
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Biology of B Cell-T Cell Interactions Room: Quandary Peak Speaker 3 of 8 Takeshi Inoue, Osaka University, Japan Germinal-Center-Mediated Memory B Cell Development Is Driven by Cooperation of Metabolic Fitness and Survival
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Biology of B Cell-T Cell Interactions Room: Quandary Peak Speaker 4 of 8 Yisi Lu, Yale University, USA CD4+ Follicular Regulatory T Cells Improve the Protective Antigen-Specific Germinal Center B Cell Responses and Promote Memory
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Biology of B Cell-T Cell Interactions Room: Quandary Peak Speaker 5 of 8 Laura Vella, University of Pennsylvania/CHOP, USA Cell States in the Thoracic Duct: Circulatory Intermediates of T Follicular Helper Cells between Lymph Nodes and Blood
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Biology of B Cell-T Cell Interactions Room: Quandary Peak Speaker 6 of 8 Tibor Z. Veres, NIAID, National Institutes of Health, USA Visualizing the Emerging Humoral Immune Response to Vaccines in 3D
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Biology of B Cell-T Cell Interactions Room: Quandary Peak Speaker 7 of 8 Lea Simoni, Boston Children's Hospital, USA Role of C4A and C4B in SLE Susceptibility and Development
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Biology of B Cell-T Cell Interactions Room: Quandary Peak Speaker 8 of 8 Hai-Hui (Howard) Xue, University of Iowa, USA Ezh2 Couples Epigenetic and Transcriptional Mechanism to Program Differentiation of Follicular Helper T Cells
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Molecular Design of Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 1 of 9 * Neil P. King, University of Washington, USA
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Molecular Design of Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 2 of 9 * Guillaume B.E. Stewart-Jones, National Institutes of Health, USA Structure-Based Design of Nipah and Parainfluenza Virus F Glycoprotein Vaccines
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Molecular Design of Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 3 of 9 Bruno Emanuel Correia, École Polytechnique Fédérale de Lausanne, Switzerland Trivalent Epitope-Focused Vaccine Elicits RSV Neutralization in NHPs
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Molecular Design of Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 4 of 9 Timothy Caradonna, Ragon Institute, USA Molecular Grafting of a Complex Broadly Neutralizing Influenza Hemagglutinin Epitope
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Molecular Design of Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 5 of 9 Syed M. Moin, National Institutes of Health, USA A Bi-Component Nanoparticle Presenting Group 1 and 2 Influenza Hemagglutinin Stem Trimers Confers Inter-Group Heterosubtypic Protections
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Molecular Design of Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 6 of 9 Seyhan Boyoglu-Barnum, National Institutes of Health, USA Computationally Designed Nanoparticles Displaying Influenza Virus Hemagglutinins of Seasonal Vaccine Strains
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Molecular Design of Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 7 of 9 Cara Chao, NIAID, National Institutes of Health, USA An Isopeptide-Linking Platform to Incorporate Trimeric Antigens into Self-Assembling Nanoparticle Immunogens
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Molecular Design of Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 8 of 9 Sean H. Kelly, Duke University, USA Molecular Design of Mucus-Penetrating Nanovaccines Enables Sublingual Peptide Immunization
Monday, February 11 \| 2:30PM - 4:30PM Workshop 1: Molecular Design of Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 9 of 9 Kshitij Wagh, Los Alamos National Laboratory, USA A Novel Glycan Shield Prediction Strategy Reveals that HIV-1 Env Glycan Shield Completeness at Transmission Determines Development of Neutralization Breadth in Natural Infection
Monday, February 11 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, February 11 \| 5:00PM - 7:00PM Regulation of the GC Response Room: Quandary Peak Speaker 1 of 4 Andre Ballesteros-Tato, University of Alabama at Birmingham, USA IL-6 Stabilizes the GC-Tfh Cell Response to Influenza by Inhibiting IL-2 Responsiveness
Monday, February 11 \| 5:00PM - 7:00PM Regulation of the GC Response Room: Quandary Peak Speaker 2 of 4 Michelle A. Linterman, Babraham Institute, UK Aging and the Germinal Centre Response
Monday, February 11 \| 5:00PM - 7:00PM Regulation of the GC Response Room: Quandary Peak Speaker 3 of 4 Di Yu, Australian National University, Australia Follicular Cytotoxic T Cells: Friends or Foes?
Monday, February 11 \| 5:00PM - 7:00PM Regulation of the GC Response Room: Quandary Peak Speaker 4 of 4 * Peter Sage, Harvard Medical School, USA Short Talk: TFR Cells Dynamically Regulate Distinct Stages of B Cell Responses
Monday, February 11 \| 5:00PM - 7:00PM Tackling Difficult Pathogens with Molecular-Based Vaccine De sign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 1 of 7 * Bruno Emanuel Correia, École Polytechnique Fédérale de Lausanne, Switzerland
Monday, February 11 \| 5:00PM - 7:00PM Tackling Difficult Pathogens with Molecular-Based Vaccine De sign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 2 of 7 * William Schief, International AIDS Vaccine Initiative and The Scripps Research Institute, USA
Monday, February 11 \| 5:00PM - 7:00PM Tackling Difficult Pathogens with Molecular-Based Vaccine De sign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 3 of 7 Ian A. Wilson, The Scripps Research Institute, USA Towards a Universal Influenza Virus Vaccine: Is it Better to Target the HA Head or Stem?
Monday, February 11 \| 5:00PM - 7:00PM Tackling Difficult Pathogens with Molecular-Based Vaccine De sign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 4 of 7 Sarah F. Andrews, National Institutes of Health, USA Identifying Common Antibody Lineages Elicited by Influenza Vaccination
Monday, February 11 \| 5:00PM - 7:00PM Tackling Difficult Pathogens with Molecular-Based Vaccine De sign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 5 of 7 Erica Ollmann Saphire, La Jolla Institute for Immunology, USA Broad-Spectrum Recognition of the Ebolaviruses
Monday, February 11 \| 5:00PM - 7:00PM Tackling Difficult Pathogens with Molecular-Based Vaccine De sign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 6 of 7 Andrew Flyak, California Institute of Technology, USA Short Talk: Common Genetic Signatures in HCV bNAbs: Implications for Vaccine Design
Monday, February 11 \| 5:00PM - 7:00PM Tackling Difficult Pathogens with Molecular-Based Vaccine De sign This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 7 of 7 Johannes P.M. Langedijk, Janssen Vaccines and Prevention, Netherlands Short Talk: Stabilization of Conserved Metastable Structural Elements in Class I Fusion Proteins for Optimal Vaccine Design
Monday, February 11 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Monday, February 11 \| 7:30PM - 10:00PM Poster Session 1 Room: Colorado Rockies Ballroom
Tuesday, February 12 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Tuesday, February 12 \| 8:00AM - 9:00AM Keynote Address (Joint) Room: Columbine Ballroom Speaker 1 of 2 * Hedda Wardemann, German Cancer Research Center, Germany
Tuesday, February 12 \| 8:00AM - 9:00AM Keynote Address (Joint) Room: Columbine Ballroom Speaker 2 of 2 Michel C. Nussenzweig, HHMI/Rockefeller University, USA Antibody Responses and Antibodies
Tuesday, February 12 \| 9:00AM - 9:30AM Coffee Break Room: Longs Peak Foyer
Tuesday, February 12 \| 9:30AM - 11:30AM Germinal Center Biology Room: Quandary Peak Speaker 1 of 5 Gabriel D. Victora, Rockefeller University, USA Clonal Dynamics of the Antibody Response
Tuesday, February 12 \| 9:30AM - 11:30AM Germinal Center Biology Room: Quandary Peak Speaker 2 of 5 Jason G. Cyster, HHMI/University of California, San Francisco, USA Germinal Center B Cell Confinement Mechanisms
Tuesday, February 12 \| 9:30AM - 11:30AM Germinal Center Biology Room: Quandary Peak Speaker 3 of 5 Tomohiro Kurosaki, Osaka University, Japan Selection Mechanisms of Germinal Center Cells into the Memory B Cell Compartment
Tuesday, February 12 \| 9:30AM - 11:30AM Germinal Center Biology Room: Quandary Peak Speaker 4 of 5 * Kim Good-Jacobson, Monash University, Australia Short Talk: Humoral Responses to Chronic Viral and Parasitic Infection are Underpinned by Dysregulation of the Polycomb Repressive Complexes
Tuesday, February 12 \| 9:30AM - 11:30AM Germinal Center Biology Room: Quandary Peak Speaker 5 of 5 Mark R. Boothby, Vanderbilt University Medical Center, USA Short Talk: Imaging & Manipulating Nutrient Micro-Milieux as B Cells Effect Humoral Immunity
Tuesday, February 12 \| 9:30AM - 11:45AM B Cell Ontogenies as Vaccine Templates This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 1 of 8 * Andrew McGuire, Fred Hutchinson Cancer Research Center, USA
Tuesday, February 12 \| 9:30AM - 11:45AM B Cell Ontogenies as Vaccine Templates This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 2 of 8 * Dennis R. Burton, The Scripps Research Institute, USA
Tuesday, February 12 \| 9:30AM - 11:45AM B Cell Ontogenies as Vaccine Templates This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 3 of 8 Penny L. Moore, University of the Witwatersrand and National Institute for Communicable Diseases, South Africa Insight into Developing Immune Systems from Pediatric Studies of HIV Infection
Tuesday, February 12 \| 9:30AM - 11:45AM B Cell Ontogenies as Vaccine Templates This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 4 of 8 William Schief, International AIDS Vaccine Initiative and The Scripps Research Institute, USA Germline-Targeting Vaccine Design
Tuesday, February 12 \| 9:30AM - 11:45AM B Cell Ontogenies as Vaccine Templates This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 5 of 8 Frederick W. Alt, Boston Children's Hospital, USA Novel Mouse Models for Lineage-Based Vaccine Studies
Tuesday, February 12 \| 9:30AM - 11:45AM B Cell Ontogenies as Vaccine Templates This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 6 of 8 Maya Sangesland, Ragon Institute of MGH, MIT and Harvard, USA Short Talk: Germline-Encoded Affinity Facilitates Vaccine-Amplification of Broadly Neutralizing Antibodies Against Influenza Virus
Tuesday, February 12 \| 9:30AM - 11:45AM B Cell Ontogenies as Vaccine Templates This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 7 of 8 Andrew J. Borst, University of Washington, USA Short Talk: Germline VRC01 Antibody Recognition of a Modified Clade C HIV-1 Envelope Trimer and a Glycosylated HIV-1 gp120 Core
Tuesday, February 12 \| 9:30AM - 11:45AM B Cell Ontogenies as Vaccine Templates This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 8 of 8 Amelia Escolano, Rockefeller University, USA Short Talk: Prime Immunization Expands Precursors of Anti HIV-1 Broadly Neutralizing Antibodies in Mice, Rabbits and Rhesus Macaques
Tuesday, February 12 \| 11:30AM - 5:00PM On Own for Lunch
Tuesday, February 12 \| 11:45AM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Tuesday, February 12 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: B and T Cell Responses in the Mucosa Room: Quandary Peak Speaker 1 of 8 Yoshimasa Takahashi, National Institute of Infectious Diseases, Japan Local Germinal Center B Cells Target Conserved Epitopes that Are Occluded in Native Viral Antigen
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: B and T Cell Responses in the Mucosa Room: Quandary Peak Speaker 2 of 8 Adi Biram, Weizmann Institute of Science, Israel Differential Roles for B Cell Receptor Affinity in Colonization of the Subepithelial Dome and Infiltration into Pre-Existing Germinal Centers within Peyer's Patches
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: B and T Cell Responses in the Mucosa Room: Quandary Peak Speaker 3 of 8 Rebecca A. Elsner, University of Pittsburgh, USA IL-12 Production during Salmonella Infection Suppresses T Follicular Helper Cell Differentiation
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: B and T Cell Responses in the Mucosa Room: Quandary Peak Speaker 4 of 8 Steven Erickson, University of Chicago, USA Polyreactive B Cells in the Mucosa
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: B and T Cell Responses in the Mucosa Room: Quandary Peak Speaker 5 of 8 Raud Razzaghi, National Institutes of Health, USA Regulation of Fas-Mediated Apoptosis in Mucosal Germinal Center B Cells
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: B and T Cell Responses in the Mucosa Room: Quandary Peak Speaker 6 of 8 Jacqueline H.Y. Siu, Cambridge University, UK Investigating Non-Conventional Memory B Cells in Human Lymphoid Tissues
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: B and T Cell Responses in the Mucosa Room: Quandary Peak Speaker 7 of 8 Marisa Stebegg, University of Cambridge, UK Faecal Microbiota Transplantation Restores the Reduced Germinal Centre Response in Peyer's Patches of Aged Mice
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: B and T Cell Responses in the Mucosa Room: Quandary Peak Speaker 8 of 8 * Duane R. Wesemann, Harvard Medical School, USA Naïve Ig Repertoire Polyreactivity Is a Tunable Feature
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: Antibody Characterization and B Cell Sequencing This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 1 of 10 * Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: Antibody Characterization and B Cell Sequencing This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 2 of 10 * Laura M. Walker, Adimab LLC, USA
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: Antibody Characterization and B Cell Sequencing This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 3 of 10 Kathryn Hastie, The Scripps Research Institute, USA Convergent Structures Reveal Key Residues to Enhance Potency and Breadth for Pan-Lassa Virus Neutralization
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: Antibody Characterization and B Cell Sequencing This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 4 of 10 Jonathan McDaniel, University of Texas at Austin, USA R21 Vaccine Elicits Near Germline Serum Antibodies that Potently Inhibit Malaria Infection
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: Antibody Characterization and B Cell Sequencing This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 5 of 10 Lan Zhang, Merck, USA Characterization of Potent RSV Neutralizing Antibodies Isolated from Human Memory B Cells and Identification of a Novel RSV/hMPV Cross-Neutralizing Epitope
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: Antibody Characterization and B Cell Sequencing This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 6 of 10 Bharat Madan, University of Kansas, USA In vitro Evolution of a Vaccine-Elicited Antibody Identifies New Capabilities for Effective Fusion Peptide-Based HIV Neutralization
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: Antibody Characterization and B Cell Sequencing This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 7 of 10 Lauren E. Gentles, University of Washington, USA Complete Antigenic Mapping of an Influenza A Virus Non-Neutralizing Antibody
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: Antibody Characterization and B Cell Sequencing This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 8 of 10 Goran Bajic, Harvard Medical School, USA Autoreactivity Profiles of Influenza Hemagglutinin Broadly Neutralizing Antibodies
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: Antibody Characterization and B Cell Sequencing This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 9 of 10 Pablo Canales Herrerias, Institut Pasteur, France Characterizing Autoantibody-Producing Cells in Thrombocytopenic Patients for Secretion Rate and Affinity for a Platelet Autoantigen
Tuesday, February 12 \| 2:30PM - 4:30PM Workshop 2: Antibody Characterization and B Cell Sequencing This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 10 of 10 Karyn McFadden, Amgen, USA Rapid Discovery of Functional Antibodies from Primary Cells using an Optofluidic Single-Cell Screening Platform
Tuesday, February 12 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, February 12 \| 5:00PM - 7:00PM B Cells and Helper T Cells Outside of B Cell Follicles Room: Quandary Peak Speaker 1 of 5 Virginia Pascual, Cornell University, USA Novel Mechanism of Extrafollicular Help in Human SLE
Tuesday, February 12 \| 5:00PM - 7:00PM B Cells and Helper T Cells Outside of B Cell Follicles Room: Quandary Peak Speaker 2 of 5 Ziv Shulman, Weizmann Institute, Israel Syk Proteasomal Degradation Regulates B Cell Fate in Germinal Centers
Tuesday, February 12 \| 5:00PM - 7:00PM B Cells and Helper T Cells Outside of B Cell Follicles Room: Quandary Peak Speaker 3 of 5 Troy D. Randall, University of Alabama at Birmingham, USA Lung-Resident Memory B Cells
Tuesday, February 12 \| 5:00PM - 7:00PM B Cells and Helper T Cells Outside of B Cell Follicles Room: Quandary Peak Speaker 4 of 5 Jason Weinstein, Rutgers New Jersey Medical School, USA Short Talk: STAT4 Regulates Pathogenic IL-21 and IFN-? Production in T Follicular Helper (Tfh) Cells in Murine and Human Lupus
Tuesday, February 12 \| 5:00PM - 7:00PM B Cells and Helper T Cells Outside of B Cell Follicles Room: Quandary Peak Speaker 5 of 5 * Tullia C. Bruno, University of Pittsburgh, USA Short Talk: Tumor-Infiltrating B Cells Co-Localize with CD4 T Effector Cells within Tertiary Lymphoid Structures to Present Antigen and Educate the Anti-Tumor Immune Response in Human Primary Tumors
Tuesday, February 12 \| 5:00PM - 7:00PM Clinical Results from Molecular-Based Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 1 of 7 * Julie Ledgerwood, NIAID, National Institutes of Health, USA
Tuesday, February 12 \| 5:00PM - 7:00PM Clinical Results from Molecular-Based Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 2 of 7 * Drew Weissman, University of Pennsylvania, USA
Tuesday, February 12 \| 5:00PM - 7:00PM Clinical Results from Molecular-Based Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 3 of 7 Sumana Chandramouli, GlaxoSmithKline Vaccines, USA A Structural Biology Approach to Developing an HCMV Vaccine
Tuesday, February 12 \| 5:00PM - 7:00PM Clinical Results from Molecular-Based Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 4 of 7 Amy S. Espeseth, Merck & Co., USA mRNA Vaccines Expressing Forms of RSV-F Protein Are Immunogenic and Protective in Preclinical Models of Respiratory Syncytial Virus Infection
Tuesday, February 12 \| 5:00PM - 7:00PM Clinical Results from Molecular-Based Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 5 of 7 Barney S. Graham, NIAID, National Institutes of Health, USA Clinical Results from the Prefusion-Stabilized RSV F (DS-Cav1) Subunit Vaccine
Tuesday, February 12 \| 5:00PM - 7:00PM Clinical Results from Molecular-Based Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 6 of 7 Katherine Burgomaster, NIAID, National Institutes of Health, USA Short Talk: Limited Cross-Reactive Antibody Responses Elicited by a ZIKV DNA Vaccine Candidate
Tuesday, February 12 \| 5:00PM - 7:00PM Clinical Results from Molecular-Based Vaccines This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 7 of 7 Adrian V. S. Hill, Jenner Institute, University of Oxford, UK Short Talk: Enhanced Efficacy of Anti-Liver-Stage Vectored Vaccines using a Prime-Target Immunisation Approach
Tuesday, February 12 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Tuesday, February 12 \| 7:30PM - 10:00PM Poster Session 2 Room: Colorado Rockies Ballroom
Wednesday, February 13 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Wednesday, February 13 \| 8:00AM - 9:30AM Keynote Session (Joint) Room: Columbine Ballroom Speaker 1 of 3 * Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Wednesday, February 13 \| 8:00AM - 9:30AM Keynote Session (Joint) Room: Columbine Ballroom Speaker 2 of 3 Facundo D. Batista, Massachusetts Institute of Technology and Harvard University, USA Importance of B Cell-T Cell Interactions in Mouse Vaccine Models
Wednesday, February 13 \| 8:00AM - 9:30AM Keynote Session (Joint) Room: Columbine Ballroom Speaker 3 of 3 Hedda Wardemann, German Cancer Research Center, Germany Development and Clonal Evolution of Human Memory B Cell Antibody Responses
Wednesday, February 13 \| 9:30AM - 10:00AM Coffee Break Room: Longs Peak Foyer
Wednesday, February 13 \| 10:00AM - 11:30AM B Cell Responses in Infectious Disease Room: Quandary Peak Speaker 1 of 4 Patrick C. Wilson, University of Chicago, USA The B Cell Response to Influenza and Vaccination
Wednesday, February 13 \| 10:00AM - 11:30AM B Cell Responses in Infectious Disease Room: Quandary Peak Speaker 2 of 4 Katherine Kedzierska, University of Melbourne, Australia B Cell and T Follicular Helper Cell Responses during Influenza Virus Infection and Vaccination
Wednesday, February 13 \| 10:00AM - 11:30AM B Cell Responses in Infectious Disease Room: Quandary Peak Speaker 3 of 4 * Ian A. Cockburn, Australian National University, Australia Short Talk: Chronic Antigen Exposure and Potent Antibody Feedback Limit Memory Responses to a Major Malaria Vaccine Candidate
Wednesday, February 13 \| 10:00AM - 11:30AM B Cell Responses in Infectious Disease Room: Quandary Peak Speaker 4 of 4 Daniel Lingwood, Havard Medical School, USA Short Talk: Natural Gene-Encoded Affinity for Cognate Antigen Facilitates Vaccine-Amplification of Broadly Neutralizing Antibodies against Influenza Virus
Wednesday, February 13 \| 10:00AM - 11:45AM Immune Monitoring of B Cell Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 1 of 7 * Brandon DeKosky, University of Kansas, USA
Wednesday, February 13 \| 10:00AM - 11:45AM Immune Monitoring of B Cell Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 2 of 7 * Frederick W. Alt, Boston Children's Hospital, USA
Wednesday, February 13 \| 10:00AM - 11:45AM Immune Monitoring of B Cell Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 3 of 7 Michael Joseph Mina, Brigham and Women's Hospital / Harvard Medical School / School of Public Health, USA Comprehensive Profiling of the Anti-Pathogen Antibody Repertoire with Phage Display and Deep Neural Networks for Infectious Disease and Vaccine Surveillance
Wednesday, February 13 \| 10:00AM - 11:45AM Immune Monitoring of B Cell Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 4 of 7 Margaret E. Ackerman, Dartmouth College, USA Measuring and Mining Serum Antibody Responses to Understand Protection from Infection
Wednesday, February 13 \| 10:00AM - 11:45AM Immune Monitoring of B Cell Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 5 of 7 Gwo-Yu Chuang, NIAID, National Institutes of Health, USA Short Talk: Delineating the Sequence Signature of a Multi-Donor Class of Human Antibodies that Broadly Neutralizes Influenza Viruses for Immune Monitoring of Vaccination Studies
Wednesday, February 13 \| 10:00AM - 11:45AM Immune Monitoring of B Cell Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 6 of 7 Colin Havenar-Daughton, Vir Biotechnology, USA Short Talk: Longitudinally Tracked, Rapid, Robust Antigen-Specific Germinal Center Responses and Somatic Hypermutation in Non-Human Primates After a Single Nanoparticle Vaccine Immunization
Wednesday, February 13 \| 10:00AM - 11:45AM Immune Monitoring of B Cell Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 7 of 7 David B. Weiner, Wistar Institute, USA Short Talk: Immunogenicity and Protection with A Low-Dose Intradermal Vaccine INO-4700 Against Middle East Respiratory Syndrome in Non-Human Primates
Wednesday, February 13 \| 11:30AM - 5:00PM On Own for Lunch
Wednesday, February 13 \| 11:45AM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Wednesday, February 13 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: B Cell-T Cell Interactions in Disease Room: Quandary Peak Speaker 1 of 8 Davide Angeletti, University of Gothenburg, Sweden Outflanking B Cell and Antibody Immunodominance to Target Subdominant Influenza A Virus Epitopes
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: B Cell-T Cell Interactions in Disease Room: Quandary Peak Speaker 2 of 8 Rachael Bashford-Rogers, University of Oxford, UK Mapping B Cell Receptor Repertoires in Six Immune-Mediated Diseases
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: B Cell-T Cell Interactions in Disease Room: Quandary Peak Speaker 3 of 8 Blair L. DeBuysscher, Fred Hutchinson Cancer Research Center, USA Mapping the HIV Envelope-Specific B Cell Population in HIV-Unexposed Individuals
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: B Cell-T Cell Interactions in Disease Room: Quandary Peak Speaker 4 of 8 Marco De Giovanni, Ospedale San Raffaele Srl, Italy Spatiotemporal Regulation of Type I Interferon Determines Antiviral CD4+ T Cell Polarization
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: B Cell-T Cell Interactions in Disease Room: Quandary Peak Speaker 5 of 8 * Joanna R. Groom, Walter and Eliza Hall Institute of Medical Research, Australia TFH/TH1 Common Precursor Requires CXCR3-Dependent Interactions at the T:B Boarder
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: B Cell-T Cell Interactions in Disease Room: Quandary Peak Speaker 6 of 8 Shi-Hsia Hwa, Africa Health Research Institute, South Africa Effects of Monoclonal Antibodies from TB Patient Lymph Node and Healthy Donor Blood on Mycobacterium tuberculosis Growth and Macrophage Infection
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: B Cell-T Cell Interactions in Disease Room: Quandary Peak Speaker 7 of 8 Amber Papillion, University of Alabama, USA Interleukin 6 Prevents the Premature Contraction of the T Follicular Helper (Tfh) Cell Response to Influenza by Precluding IL-2 Responsiveness of GC-Tfh Cells
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: B Cell-T Cell Interactions in Disease Room: Quandary Peak Speaker 8 of 8 William T. Yewdell, Memorial Sloan Kettering Cancer Center, USA Striking Features of the Memory B Cell Response to Influenza Infection
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: Molecular Probing of the Elicited Vaccine Respon se This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 1 of 9 * George Georgiou, University of Texas at Austin, USA
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: Molecular Probing of the Elicited Vaccine Respon se This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 2 of 9 * Pierre Bruhns, Institut Pasteur, France
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: Molecular Probing of the Elicited Vaccine Respon se This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 3 of 9 Maryam Mukhamedova, NIAID, National Institutes of Health, USA Characterization of RSV Antibody Repertoire to B Cells Elicited by Prefusion RSV F Subunit Protein (DS-Cav1)-Vaccinated Adult Volunteers
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: Molecular Probing of the Elicited Vaccine Respon se This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 4 of 9 Raffaello Verardi, NIAID, National Institutes of Health, USA Structural Studies of Human Norovirus Antibodies Isolated from Vaccines Reveal Basis for Broad Reactivity
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: Molecular Probing of the Elicited Vaccine Respon se This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 5 of 9 Christopher A. Cottrell, The Scripps Research Institute, USA Immunofocusing Antibody Responses to Target the HIV Env Fusion Peptide (FP) Epitope in Non-Human Primates (NHPs)
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: Molecular Probing of the Elicited Vaccine Respon se This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 6 of 9 Zizhang Sheng, Columbia University, USA Developmental Pathways for Vaccine-Induced Neutralizing Antibodies Targeting the HIV-1 Fusion Peptide Suggest a Low Barrier to Elicitation
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: Molecular Probing of the Elicited Vaccine Respon se This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 7 of 9 Rajagopal Murugan, German Cancer Research Institute, Germany Maturation of the Memory B Cell Response to Plasmodium Falciparum Circumsporozoite Protein (PfCSP) through Clonal Selection, Not Affinity Maturation
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: Molecular Probing of the Elicited Vaccine Respon se This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 8 of 9 Elisabetta Frigimelica, GlaxoSmithKline Vaccines S.r.l., Italy Characterization of the Human Antibody Repertoire Following Immunization with Meningococcus B Vaccine
Wednesday, February 13 \| 2:30PM - 4:30PM Workshop 3: Molecular Probing of the Elicited Vaccine Respon se This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 9 of 9 Murillo Silva, Massachusetts Institute of Technology, USA Saponin-MPLA Nanoparticulate Adjuvants Alter Lymph Flow and Enhance Early Antigen Acquisition by B Cells
Wednesday, February 13 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, February 13 \| 5:00PM - 7:00PM Memory Humoral Responses Room: Quandary Peak Speaker 1 of 4 Marc K. Jenkins, University of Minnesota Medical School, USA Memory T and B Cell Responses
Wednesday, February 13 \| 5:00PM - 7:00PM Memory Humoral Responses Room: Quandary Peak Speaker 2 of 4 Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA Heterogeneity of Memory B Cell Compartments
Wednesday, February 13 \| 5:00PM - 7:00PM Memory Humoral Responses Room: Quandary Peak Speaker 3 of 4 Marion Pepper, University of Washington, USA Memory B Cells in Plasmodium Infection
Wednesday, February 13 \| 5:00PM - 7:00PM Memory Humoral Responses Room: Quandary Peak Speaker 4 of 4 * Claude-Agnès Reynaud, Necker-Paris Medical School, France Short Talk: A Splenic IgM Memory Subset Harboring Anti-Bacterial Specificities is Sustained from Persistent Mucosal Germinal Center Reactions
Wednesday, February 13 \| 5:00PM - 7:00PM Optimizing Vaccine Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 1 of 7 * Ian A. Wilson, The Scripps Research Institute, USA
Wednesday, February 13 \| 5:00PM - 7:00PM Optimizing Vaccine Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 2 of 7 * Peter D. Kwong, NIAID, National Institutes of Health, USA
Wednesday, February 13 \| 5:00PM - 7:00PM Optimizing Vaccine Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 3 of 7 Neil P. King, University of Washington, USA Computational Design of Protein Nanomaterials for Next-Generation Vaccine Design
Wednesday, February 13 \| 5:00PM - 7:00PM Optimizing Vaccine Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 4 of 7 Günther Staffler, AFFiRiS AG, Austria Towards a Heart Attack Vaccine: PCSK9 as a Immunogen
Wednesday, February 13 \| 5:00PM - 7:00PM Optimizing Vaccine Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 5 of 7 Pierre Bruhns, Institut Pasteur, France Monitoring Plasmablast Responses at the Single Cell Level
Wednesday, February 13 \| 5:00PM - 7:00PM Optimizing Vaccine Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 6 of 7 Sonia M. Maciejewski, NIAID, National Institutes of Health, USA Short Talk: Distinct Correlates of Protection Among Closely Related ZIKV DNA Vaccines Identify a Critical Role for Antibody Quality Following Vaccination
Wednesday, February 13 \| 5:00PM - 7:00PM Optimizing Vaccine Responses This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 7 of 7 Kimberly M. Cirelli, La Jolla Institute for Immunology, USA Short Talk: Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance
Wednesday, February 13 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Wednesday, February 13 \| 7:30PM - 10:00PM Poster Session 3 Room: Colorado Rockies Ballroom
Thursday, February 14 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Thursday, February 14 \| 8:00AM - 11:00AM Humoral Autoimmunity and Allergic Responses Room: Quandary Peak Speaker 1 of 7 Rachel Ettinger, Viela Bio, USA VIB4920, a Novel CD40L Antagonist, Decreased Disease Activity and Improved Biomarkers of Immune Activation in a Phase 1b, Proof-of-Concept Study in Rheumatoid Arthritis
Thursday, February 14 \| 8:00AM - 11:00AM Humoral Autoimmunity and Allergic Responses Room: Quandary Peak Speaker 2 of 7 Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA Epitope Spreading in Autoimmune Germinal Centers
Thursday, February 14 \| 8:00AM - 11:00AM Humoral Autoimmunity and Allergic Responses Room: Quandary Peak Coffee Break
Thursday, February 14 \| 8:00AM - 11:00AM Humoral Autoimmunity and Allergic Responses Room: Quandary Peak Speaker 4 of 7 * Maria A. Curotto de Lafaille, New York University School of Medicine, USA Biology of IgE Affinity Maturation
Thursday, February 14 \| 8:00AM - 11:00AM Humoral Autoimmunity and Allergic Responses Room: Quandary Peak Speaker 5 of 7 Christopher C. Goodnow, Garvan Institute of Medical Research, Australia Progression from Benign to Pathogenic Autoantibody by Somatic Mutation in a Rogue Clone: Single Cell RNA and DNA Sequencing
Thursday, February 14 \| 8:00AM - 11:00AM Humoral Autoimmunity and Allergic Responses Room: Quandary Peak Speaker 6 of 7 Fleur du Pre, University of Oslo and Oslo University Hospital, Norway Short Talk: A Celiac Disease Patient-Derived Anti-TG2 Antibody Is not Tolerized in Mice
Thursday, February 14 \| 8:00AM - 11:00AM Humoral Autoimmunity and Allergic Responses Room: Quandary Peak Speaker 7 of 7 Brigette Boast, Australian National University, Australia Short Talk: ARPC1B-/- Mice Suggest a New Role for DOCK8 in the Murine Germinal Center Response
Thursday, February 14 \| 8:00AM - 11:15AM Vaccines: Better, Faster and Less Expensive! This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 1 of 12 * Amy S. Espeseth, Merck & Co., USA
Thursday, February 14 \| 8:00AM - 11:15AM Vaccines: Better, Faster and Less Expensive! This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 2 of 12 * Barney S. Graham, NIAID, National Institutes of Health, USA
Thursday, February 14 \| 8:00AM - 11:15AM Vaccines: Better, Faster and Less Expensive! This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 3 of 12 Rino Rappuoli, GlaxoSmithKline Vaccines, Italy Developing Vaccines against Pandemics and for the Developing World
Thursday, February 14 \| 8:00AM - 11:15AM Vaccines: Better, Faster and Less Expensive! This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 4 of 12 Laura M. Walker, Adimab LLC, USA Generation of Broad and Potent Neutralizing Antibodies to Speed Pandemic Responses
Thursday, February 14 \| 8:00AM - 11:15AM Vaccines: Better, Faster and Less Expensive! This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Coffee Break
Thursday, February 14 \| 8:00AM - 11:15AM Vaccines: Better, Faster and Less Expensive! This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 6 of 12 * Jeffrey B. Ulmer, GlaxoSmithKline Vaccines, USA
Thursday, February 14 \| 8:00AM - 11:15AM Vaccines: Better, Faster and Less Expensive! This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 7 of 12 * David B. Weiner, Wistar Institute, USA
Thursday, February 14 \| 8:00AM - 11:15AM Vaccines: Better, Faster and Less Expensive! This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 8 of 12 Brandon DeKosky, University of Kansas, USA Paired Heavy-Light Chain Sequencing and Display for Immune Monitoring of Vaccination and Natural Infection
Thursday, February 14 \| 8:00AM - 11:15AM Vaccines: Better, Faster and Less Expensive! This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 9 of 12 Julie Ledgerwood, NIAID, National Institutes of Health, USA Immune Monitoring to Increase the Likelihood of Phase 2 Success
Thursday, February 14 \| 8:00AM - 11:15AM Vaccines: Better, Faster and Less Expensive! This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 10 of 12 Ami Patel, Wistar Institute, USA Short Talk: Infection to Protection: An in vivo Approach for Rapid Delivery of DNA-Encoded Monoclonal Antibodies (DMAbs) Isolated Directly from Ebola Virus Disease Survivors and Other Infectious Diseases
Thursday, February 14 \| 8:00AM - 11:15AM Vaccines: Better, Faster and Less Expensive! This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 11 of 12 Julia Lederhofer, NIAID, National Institutes of Health, USA Short Talk: Augmented Immune Responses by Co-Immunization of Commercial Seasonal Influenza Vaccine and the HA Stem-Based Universal Influenza Vaccine Candidates
Thursday, February 14 \| 8:00AM - 11:15AM Vaccines: Better, Faster and Less Expensive! This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 12 of 12 Daniel R. Ellis, University of Washington, USA Short Talk: Co-Display of Multiple Antigenic Variants on Computationally-Designed Protein Nanomaterials as a Versatile Vaccine Platform
Thursday, February 14 \| 11:00AM - 5:00PM On Own for Lunch
Thursday, February 14 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, February 14 \| 5:00PM - 6:45PM T-Dependent B Cell Differentiation Room: Quandary Peak Speaker 1 of 4 Brian J. Laidlaw, University of California, San Francisco, USA Short Talk: Transcriptional Regulation of Memory B Cell Development Following Viral Infection
Thursday, February 14 \| 5:00PM - 6:45PM T-Dependent B Cell Differentiation Room: Quandary Peak Speaker 2 of 4 Meinrad Busslinger, Research Institute of Molecular Pathology, Austria Ikaros Prevents Autoimmunity by Promoting Anergy Induction and Restraining Toll-Like Receptor Signaling in B Cells
Thursday, February 14 \| 5:00PM - 6:45PM T-Dependent B Cell Differentiation Room: Quandary Peak Speaker 3 of 4 Robert Brink, Garvan Institute of Medical Research, Australia Constant Region-Based Selection in the Germinal Center Reaction
Thursday, February 14 \| 5:00PM - 6:45PM T-Dependent B Cell Differentiation Room: Quandary Peak Speaker 4 of 4 * Kai-Michael Toellner, University of Birmingham, UK Short Talk: CCL19/CCL21 Direct Memory B Cell Reentry in Reactive Lymph Nodes
Thursday, February 14 \| 5:00PM - 6:45PM Reducing Vaccine Risks and Costs This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 1 of 5 * Margaret E. Ackerman, Dartmouth College, USA
Thursday, February 14 \| 5:00PM - 6:45PM Reducing Vaccine Risks and Costs This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 2 of 5 * Rino Rappuoli, GlaxoSmithKline Vaccines, Italy
Thursday, February 14 \| 5:00PM - 6:45PM Reducing Vaccine Risks and Costs This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 3 of 5 Jeffrey B. Ulmer, GlaxoSmithKline Vaccines, USA Molecular Approaches to Streamlining Vaccine Discovery and Development
Thursday, February 14 \| 5:00PM - 6:45PM Reducing Vaccine Risks and Costs This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 4 of 5 Drew Weissman, University of Pennsylvania, USA Advantages of an mRNA Vaccine Approach
Thursday, February 14 \| 5:00PM - 6:45PM Reducing Vaccine Risks and Costs This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak Speaker 5 of 5 Gary J. Nabel, Sanofi, USA Innovation in Antibody Structure and Design to Optimize Protection and Improve Efficacy: Vaccine Implications
Thursday, February 14 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Quandary Peak
Thursday, February 14 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) This session is from Vaccines & Imm Monitoring Room: Grays/Longs Peak
Thursday, February 14 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Thursday, February 14 \| 8:00PM - 11:00PM Entertainment Room: Colorado Rockies Ballroom Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, February 14 \| 8:00PM - 11:00PM Cash Bar Room: Colorado Rockies Ballroom
Friday, February 15 \| 10:24AM - 10:24AM Departure *Session Chair †Invited, not yet responded.