Web Desc
B Cell-T Cell Interactions
joint with Molecular Approaches to Vaccines and Immune Monitoring
Organizer(s): Gabriel D. Victora and Carola G. Vinuesa
Date: February 10 - 14, 2019
Location: Keystone Resort, Keystone, CO, USA
Sponsored by BioLegend, Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
B cell-T cell interactions bring about the maturation and production of high affinity antibodies and are key to the establishment of effective humoral immunity. While this greatly enhances our ability to fight pathogens, it also can lead to the development of allergies and autoimmune disease. While recent years have seen a burst in our understanding of how B cell-T cell interactions drive antibody affinity maturation, a number of gaps remain, including how these interactions influence the differentiation of B cells into effector fates and how they limit the emergence of autoreactive B cell clones. Most importantly, from the vaccine standpoint, it is likely that better understanding of how T cell help shapes the B cell repertoire will allow us to better control the specificity of vaccine-induced immune responses. The aim of this Keystone symposium will be to: (1) Present the most recent advances in the basic biology of the T cell-dependent B cell response, focusing on Tfh development and function and B cell activation and differentiation; (2) address the gap in our understanding the differentiation of B cells into post-activation (memory and plasma cell) fates; (3) discuss how furthering our understanding of B cell-T cell interactions can inform vaccine development; and (4) present recent findings regarding the role of T-cell dependent B cell response in allergy and autoimmunity.
Scholarship Deadline: October 23 2018
Discounted Abstract Deadline: October 23 2018
Abstract Deadline: November 7 2018
Discounted Registration Deadline: December 6 2018
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
BioLegend, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Viela Bio
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI140576-01
Funding for this conference was made possible (in part) by 1 R13 AI140576-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, February 10 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, February 10 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Monday, February 11 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 1 of 2
* Facundo D. Batista, Massachusetts Institute of Technology and Harvard University, USA

Monday, February 11 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 2 of 2
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
The B Cell Immune Response to Infection and Vaccination

Monday, February 11 | 9:00AM - 9:30AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 11 | 9:30AM - 11:30AM
Tfh Biology
Room: Quandary Peak

Speaker 1 of 5
Carola G. Vinuesa, Australian National University, Australia
Human Tfh Biology

Monday, February 11 | 9:30AM - 11:30AM
Tfh Biology
Room: Quandary Peak

Speaker 2 of 5
Hai Qi, Tsinghua University, China
Guidance Cues for Tfh Cells

Monday, February 11 | 9:30AM - 11:30AM
Tfh Biology
Room: Quandary Peak

Speaker 3 of 5
Shane Crotty, La Jolla Institute for Immunology, USA
Tfh Cell and Germinal Center B Cell Responses in the Context of Infections and Vaccines

Monday, February 11 | 9:30AM - 11:30AM
Tfh Biology
Room: Quandary Peak

Speaker 4 of 5
* Pamela L. Schwartzberg, NIAID, NHGRI, National Institutes of Health, USA
Short Talk: PI3 Kinase-Mediated Pathways Orchestrate T and B Cell Contributions to Humoral Responses during Immunization and Infection

Monday, February 11 | 9:30AM - 11:30AM
Tfh Biology
Room: Quandary Peak

Speaker 5 of 5
Stephanie C. Eisenbarth, Yale University, USA
Short Talk: A Unique Subset of Tfh Cells Drives High-Affinity IgE Production

Monday, February 11 | 9:30AM - 11:45AM
Targeting Appropriate Immune Responses for Structure-Based D
esign
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 1 of 8
* Erica Ollmann Saphire, La Jolla Institute for Immunology, USA


Monday, February 11 | 9:30AM - 11:45AM
Targeting Appropriate Immune Responses for Structure-Based D
esign
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 2 of 8
* Gary J. Nabel, Sanofi, USA


Monday, February 11 | 9:30AM - 11:45AM
Targeting Appropriate Immune Responses for Structure-Based D
esign
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 3 of 8
Dennis R. Burton, The Scripps Research Institute, USA
From Antibody to Vaccine


Monday, February 11 | 9:30AM - 11:45AM
Targeting Appropriate Immune Responses for Structure-Based D
esign
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 4 of 8
George Georgiou, University of Texas at Austin, USA
Molecular Definition of Protective Serum Responses from Vaccination and for Immune Monitoring


Monday, February 11 | 9:30AM - 11:45AM
Targeting Appropriate Immune Responses for Structure-Based D
esign
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 5 of 8
Peter D. Kwong, NIAID, National Institutes of Health, USA
Antibody-Guided Structure-Based Vaccines: Challenges and Opportunities


Monday, February 11 | 9:30AM - 11:45AM
Targeting Appropriate Immune Responses for Structure-Based D
esign
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 6 of 8
Evelien M. Bunnik, University of Texas Health Science Center, USA
Short Talk: Naturally Acquired Protective Humoral Immunity Against Malaria


Monday, February 11 | 9:30AM - 11:45AM
Targeting Appropriate Immune Responses for Structure-Based D
esign
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 7 of 8
Nisreen Mamdouh Ahmed Okba, Erasmus MC, Netherlands
Short Talk: Antibody Responses as Blueprint for MERS-CoV Rational Vaccine Design


Monday, February 11 | 9:30AM - 11:45AM
Targeting Appropriate Immune Responses for Structure-Based D
esign
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 8 of 8
Andrew McGuire, Fred Hutchinson Cancer Research Center, USA
Short Talk: An Anti-gH/gL Antibody that Neutralizes Dual-Tropic Infection Defines a Site of Vulnerability on Epstein-Barr Virus


Monday, February 11 | 11:30AM - 5:00PM
On Own for Lunch


Monday, February 11 | 11:45AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Monday, February 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Biology of B Cell-T Cell Interactions
Room: Quandary Peak

Speaker 1 of 8
* Dirk Baumjohann, Ludwig-Maximilians-University Munich, Germany
T Cell-Expressed MicroRNAs Critically Regulate Germinal Center Tfh and B Cell Function and Maintenance

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Biology of B Cell-T Cell Interactions
Room: Quandary Peak

Speaker 2 of 8
Numana Bhat, Sanford Burnham Prebys Medical Discovery Institute, USA
Regnase-1 Is Essential for Controlling Aberrant Differentiation of B Cells during Maturation and T Dependent B Cell Response

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Biology of B Cell-T Cell Interactions
Room: Quandary Peak

Speaker 3 of 8
Takeshi Inoue, Osaka University, Japan
Germinal-Center-Mediated Memory B Cell Development Is Driven by Cooperation of Metabolic Fitness and Survival

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Biology of B Cell-T Cell Interactions
Room: Quandary Peak

Speaker 4 of 8
Yisi Lu, Yale University, USA
CD4+ Follicular Regulatory T Cells Improve the Protective Antigen-Specific Germinal Center B Cell Responses and Promote Memory

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Biology of B Cell-T Cell Interactions
Room: Quandary Peak

Speaker 5 of 8
Laura Vella, University of Pennsylvania/CHOP, USA
Cell States in the Thoracic Duct: Circulatory Intermediates of T Follicular Helper Cells between Lymph Nodes and Blood

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Biology of B Cell-T Cell Interactions
Room: Quandary Peak

Speaker 6 of 8
Tibor Z. Veres, NIAID, National Institutes of Health, USA
Visualizing the Emerging Humoral Immune Response to Vaccines in 3D

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Biology of B Cell-T Cell Interactions
Room: Quandary Peak

Speaker 7 of 8
Lea Simoni, Boston Children's Hospital, USA
Role of C4A and C4B in SLE Susceptibility and Development

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Biology of B Cell-T Cell Interactions
Room: Quandary Peak

Speaker 8 of 8
Hai-Hui (Howard) Xue, University of Iowa, USA
Ezh2 Couples Epigenetic and Transcriptional Mechanism to Program Differentiation of Follicular Helper T Cells

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Molecular Design of Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 1 of 9
* Neil P. King, University of Washington, USA


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Molecular Design of Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 2 of 9
* Guillaume B.E. Stewart-Jones, National Institutes of Health, USA
Structure-Based Design of Nipah and Parainfluenza Virus F Glycoprotein Vaccines


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Molecular Design of Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 3 of 9
Bruno Emanuel Correia, École Polytechnique Fédérale de Lausanne, Switzerland
Trivalent Epitope-Focused Vaccine Elicits RSV Neutralization in NHPs


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Molecular Design of Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 4 of 9
Timothy Caradonna, Ragon Institute, USA
Molecular Grafting of a Complex Broadly Neutralizing Influenza Hemagglutinin Epitope


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Molecular Design of Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 5 of 9
Syed M. Moin, National Institutes of Health, USA
A Bi-Component Nanoparticle Presenting Group 1 and 2 Influenza Hemagglutinin Stem Trimers Confers Inter-Group Heterosubtypic Protections


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Molecular Design of Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 6 of 9
Seyhan Boyoglu-Barnum, National Institutes of Health, USA
Computationally Designed Nanoparticles Displaying Influenza Virus Hemagglutinins of Seasonal Vaccine Strains


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Molecular Design of Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 7 of 9
Cara Chao, NIAID, National Institutes of Health, USA
An Isopeptide-Linking Platform to Incorporate Trimeric Antigens into Self-Assembling Nanoparticle Immunogens


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Molecular Design of Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 8 of 9
Sean H. Kelly, Duke University, USA
Molecular Design of Mucus-Penetrating Nanovaccines Enables Sublingual Peptide Immunization


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Molecular Design of Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 9 of 9
Kshitij Wagh, Los Alamos National Laboratory, USA
A Novel Glycan Shield Prediction Strategy Reveals that HIV-1 Env Glycan Shield Completeness at Transmission Determines Development of Neutralization Breadth in Natural Infection


Monday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 11 | 5:00PM - 7:00PM
Regulation of the GC Response
Room: Quandary Peak

Speaker 1 of 4
Andre Ballesteros-Tato, University of Alabama at Birmingham, USA
IL-6 Stabilizes the GC-Tfh Cell Response to Influenza by Inhibiting IL-2 Responsiveness

Monday, February 11 | 5:00PM - 7:00PM
Regulation of the GC Response
Room: Quandary Peak

Speaker 2 of 4
Michelle A. Linterman, Babraham Institute, UK
Aging and the Germinal Centre Response

Monday, February 11 | 5:00PM - 7:00PM
Regulation of the GC Response
Room: Quandary Peak

Speaker 3 of 4
Di Yu, Australian National University, Australia
Follicular Cytotoxic T Cells: Friends or Foes?

Monday, February 11 | 5:00PM - 7:00PM
Regulation of the GC Response
Room: Quandary Peak

Speaker 4 of 4
* Peter Sage, Harvard Medical School, USA
Short Talk: TFR Cells Dynamically Regulate Distinct Stages of B Cell Responses

Monday, February 11 | 5:00PM - 7:00PM
Tackling Difficult Pathogens with Molecular-Based Vaccine De
sign 
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 1 of 7
* Bruno Emanuel Correia, École Polytechnique Fédérale de Lausanne, Switzerland


Monday, February 11 | 5:00PM - 7:00PM
Tackling Difficult Pathogens with Molecular-Based Vaccine De
sign 
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 2 of 7
* William Schief, International AIDS Vaccine Initiative and The Scripps Research Institute, USA


Monday, February 11 | 5:00PM - 7:00PM
Tackling Difficult Pathogens with Molecular-Based Vaccine De
sign 
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 3 of 7
Ian A. Wilson, The Scripps Research Institute, USA
Towards a Universal Influenza Virus Vaccine: Is it Better to Target the HA Head or Stem?


Monday, February 11 | 5:00PM - 7:00PM
Tackling Difficult Pathogens with Molecular-Based Vaccine De
sign 
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 4 of 7
Sarah F. Andrews, National Institutes of Health, USA
Identifying Common Antibody Lineages Elicited by Influenza Vaccination


Monday, February 11 | 5:00PM - 7:00PM
Tackling Difficult Pathogens with Molecular-Based Vaccine De
sign 
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 5 of 7
Erica Ollmann Saphire, La Jolla Institute for Immunology, USA
Broad-Spectrum Recognition of the Ebolaviruses


Monday, February 11 | 5:00PM - 7:00PM
Tackling Difficult Pathogens with Molecular-Based Vaccine De
sign 
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 6 of 7
Andrew Flyak, California Institute of Technology, USA
Short Talk: Common Genetic Signatures in HCV bNAbs: Implications for Vaccine Design


Monday, February 11 | 5:00PM - 7:00PM
Tackling Difficult Pathogens with Molecular-Based Vaccine De
sign 
This session is from Vaccines & Imm Monitoring

Room: Grays/Longs Peak

Speaker 7 of 7
Johannes P.M. Langedijk, Janssen Vaccines and Prevention, Netherlands
Short Talk: Stabilization of Conserved Metastable Structural Elements in Class I Fusion Proteins for Optimal Vaccine Design


Monday, February 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, February 11 | 7:30PM - 10:00PM
Poster Session 1
Room: Colorado Rockies Ballroom


Tuesday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Tuesday, February 12 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 1 of 2
* Hedda Wardemann, German Cancer Research Center, Germany

Tuesday, February 12 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 2 of 2
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Antibody Responses and Antibodies

Tuesday, February 12 | 9:00AM - 9:30AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 12 | 9:30AM - 11:30AM
Germinal Center Biology
Room: Quandary Peak

Speaker 1 of 5
Gabriel D. Victora, Rockefeller University, USA
Clonal Dynamics of the Antibody Response

Tuesday, February 12 | 9:30AM - 11:30AM
Germinal Center Biology
Room: Quandary Peak

Speaker 2 of 5
Jason G. Cyster, HHMI/University of California, San Francisco, USA
Germinal Center B Cell Confinement Mechanisms

Tuesday, February 12 | 9:30AM - 11:30AM
Germinal Center Biology
Room: Quandary Peak

Speaker 3 of 5
Tomohiro Kurosaki, Osaka University, Japan
Selection Mechanisms of Germinal Center Cells into the Memory B Cell Compartment

Tuesday, February 12 | 9:30AM - 11:30AM
Germinal Center Biology
Room: Quandary Peak

Speaker 4 of 5
* Kim Good-Jacobson, Monash University, Australia
Short Talk: Humoral Responses to Chronic Viral and Parasitic Infection are Underpinned by Dysregulation of the Polycomb Repressive Complexes

Tuesday, February 12 | 9:30AM - 11:30AM
Germinal Center Biology
Room: Quandary Peak

Speaker 5 of 5
Mark R. Boothby, Vanderbilt University Medical Center, USA
Short Talk: Imaging & Manipulating Nutrient Micro-Milieux as B Cells Effect Humoral Immunity

Tuesday, February 12 | 9:30AM - 11:45AM
B Cell Ontogenies as Vaccine Templates
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 1 of 8
* Andrew McGuire, Fred Hutchinson Cancer Research Center, USA


Tuesday, February 12 | 9:30AM - 11:45AM
B Cell Ontogenies as Vaccine Templates
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 2 of 8
* Dennis R. Burton, The Scripps Research Institute, USA


Tuesday, February 12 | 9:30AM - 11:45AM
B Cell Ontogenies as Vaccine Templates
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 3 of 8
Penny L. Moore, University of the Witwatersrand and National Institute for Communicable Diseases, South Africa
Insight into Developing Immune Systems from Pediatric Studies of HIV Infection


Tuesday, February 12 | 9:30AM - 11:45AM
B Cell Ontogenies as Vaccine Templates
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 4 of 8
William Schief, International AIDS Vaccine Initiative and The Scripps Research Institute, USA
Germline-Targeting Vaccine Design


Tuesday, February 12 | 9:30AM - 11:45AM
B Cell Ontogenies as Vaccine Templates
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 5 of 8
Frederick W. Alt, Boston Children's Hospital, USA
Novel Mouse Models for Lineage-Based Vaccine Studies


Tuesday, February 12 | 9:30AM - 11:45AM
B Cell Ontogenies as Vaccine Templates
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 6 of 8
Maya Sangesland, Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: Germline-Encoded Affinity Facilitates Vaccine-Amplification of Broadly Neutralizing Antibodies Against Influenza Virus


Tuesday, February 12 | 9:30AM - 11:45AM
B Cell Ontogenies as Vaccine Templates
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 7 of 8
Andrew J. Borst, University of Washington, USA
Short Talk: Germline VRC01 Antibody Recognition of a Modified Clade C HIV-1 Envelope Trimer and a Glycosylated HIV-1 gp120 Core


Tuesday, February 12 | 9:30AM - 11:45AM
B Cell Ontogenies as Vaccine Templates
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 8 of 8
Amelia Escolano, Rockefeller University, USA
Short Talk: Prime Immunization Expands Precursors of Anti HIV-1 Broadly Neutralizing Antibodies in Mice, Rabbits and Rhesus Macaques


Tuesday, February 12 | 11:30AM - 5:00PM
On Own for Lunch


Tuesday, February 12 | 11:45AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Tuesday, February 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: B and T Cell Responses in the Mucosa
Room: Quandary Peak

Speaker 1 of 8
Yoshimasa Takahashi, National Institute of Infectious Diseases, Japan
Local Germinal Center B Cells Target Conserved Epitopes that Are Occluded in Native Viral Antigen

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: B and T Cell Responses in the Mucosa
Room: Quandary Peak

Speaker 2 of 8
Adi Biram, Weizmann Institute of Science, Israel
Differential Roles for B Cell Receptor Affinity in Colonization of the Subepithelial Dome and Infiltration into Pre-Existing Germinal Centers within Peyer's Patches

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: B and T Cell Responses in the Mucosa
Room: Quandary Peak

Speaker 3 of 8
Rebecca A. Elsner, University of Pittsburgh, USA
IL-12 Production during Salmonella Infection Suppresses T Follicular Helper Cell Differentiation

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: B and T Cell Responses in the Mucosa
Room: Quandary Peak

Speaker 4 of 8
Steven Erickson, University of Chicago, USA
Polyreactive B Cells in the Mucosa

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: B and T Cell Responses in the Mucosa
Room: Quandary Peak

Speaker 5 of 8
Raud Razzaghi, National Institutes of Health, USA
Regulation of Fas-Mediated Apoptosis in Mucosal Germinal Center B Cells

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: B and T Cell Responses in the Mucosa
Room: Quandary Peak

Speaker 6 of 8
Jacqueline H.Y. Siu, Cambridge University, UK
Investigating Non-Conventional Memory B Cells in Human Lymphoid Tissues

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: B and T Cell Responses in the Mucosa
Room: Quandary Peak

Speaker 7 of 8
Marisa Stebegg, University of Cambridge, UK
Faecal Microbiota Transplantation Restores the Reduced Germinal Centre Response in Peyer's Patches of Aged Mice

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: B and T Cell Responses in the Mucosa
Room: Quandary Peak

Speaker 8 of 8
* Duane R. Wesemann, Harvard Medical School, USA
Naïve Ig Repertoire Polyreactivity Is a Tunable Feature

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: Antibody Characterization and B Cell Sequencing
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 1 of 10
* Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: Antibody Characterization and B Cell Sequencing
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 2 of 10
* Laura M. Walker, Adimab LLC, USA


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: Antibody Characterization and B Cell Sequencing
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 3 of 10
Kathryn Hastie, The Scripps Research Institute, USA
Convergent Structures Reveal Key Residues to Enhance Potency and Breadth for Pan-Lassa Virus Neutralization


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: Antibody Characterization and B Cell Sequencing
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 4 of 10
Jonathan McDaniel, University of Texas at Austin, USA
R21 Vaccine Elicits Near Germline Serum Antibodies that Potently Inhibit Malaria Infection


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: Antibody Characterization and B Cell Sequencing
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 5 of 10
Lan Zhang, Merck, USA
Characterization of Potent RSV Neutralizing Antibodies Isolated from Human Memory B Cells and Identification of a Novel RSV/hMPV Cross-Neutralizing Epitope


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: Antibody Characterization and B Cell Sequencing
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 6 of 10
Bharat Madan, University of Kansas, USA
In vitro Evolution of a Vaccine-Elicited Antibody Identifies New Capabilities for Effective Fusion Peptide-Based HIV Neutralization


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: Antibody Characterization and B Cell Sequencing
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 7 of 10
Lauren E. Gentles, University of Washington, USA
Complete Antigenic Mapping of an Influenza A Virus Non-Neutralizing Antibody


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: Antibody Characterization and B Cell Sequencing
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 8 of 10
Goran Bajic, Harvard Medical School, USA
Autoreactivity Profiles of Influenza Hemagglutinin Broadly Neutralizing Antibodies


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: Antibody Characterization and B Cell Sequencing
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 9 of 10
Pablo Canales Herrerias, Institut Pasteur, France
Characterizing Autoantibody-Producing Cells in Thrombocytopenic Patients for Secretion Rate and Affinity for a Platelet Autoantigen


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 2: Antibody Characterization and B Cell Sequencing
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 10 of 10
Karyn McFadden, Amgen, USA
Rapid Discovery of Functional Antibodies from Primary Cells using an Optofluidic Single-Cell Screening Platform


Tuesday, February 12 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 12 | 5:00PM - 7:00PM
B Cells and Helper T Cells Outside of B Cell Follicles
Room: Quandary Peak

Speaker 1 of 5
Virginia Pascual, Cornell University, USA
Novel Mechanism of Extrafollicular Help in Human SLE


Tuesday, February 12 | 5:00PM - 7:00PM
B Cells and Helper T Cells Outside of B Cell Follicles
Room: Quandary Peak

Speaker 2 of 5
Ziv Shulman, Weizmann Institute, Israel
Syk Proteasomal Degradation Regulates B Cell Fate in Germinal Centers

Tuesday, February 12 | 5:00PM - 7:00PM
B Cells and Helper T Cells Outside of B Cell Follicles
Room: Quandary Peak

Speaker 3 of 5
Troy D. Randall, University of Alabama at Birmingham, USA
Lung-Resident Memory B Cells

Tuesday, February 12 | 5:00PM - 7:00PM
B Cells and Helper T Cells Outside of B Cell Follicles
Room: Quandary Peak

Speaker 4 of 5
Jason Weinstein, Rutgers New Jersey Medical School, USA
Short Talk: STAT4 Regulates Pathogenic IL-21 and IFN-? Production in T Follicular Helper (Tfh) Cells in Murine and Human Lupus

Tuesday, February 12 | 5:00PM - 7:00PM
B Cells and Helper T Cells Outside of B Cell Follicles
Room: Quandary Peak

Speaker 5 of 5
* Tullia C. Bruno, University of Pittsburgh, USA
Short Talk: Tumor-Infiltrating B Cells Co-Localize with CD4 T Effector Cells within Tertiary Lymphoid Structures to Present
Antigen and Educate the Anti-Tumor Immune Response in Human Primary Tumors


Tuesday, February 12 | 5:00PM - 7:00PM
Clinical Results from Molecular-Based Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 1 of 7
* Julie Ledgerwood, NIAID, National Institutes of Health, USA


Tuesday, February 12 | 5:00PM - 7:00PM
Clinical Results from Molecular-Based Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 2 of 7
* Drew Weissman, University of Pennsylvania, USA


Tuesday, February 12 | 5:00PM - 7:00PM
Clinical Results from Molecular-Based Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 3 of 7
Sumana Chandramouli, GlaxoSmithKline Vaccines, USA
A Structural Biology Approach to Developing an HCMV Vaccine


Tuesday, February 12 | 5:00PM - 7:00PM
Clinical Results from Molecular-Based Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 4 of 7
Amy S. Espeseth, Merck & Co., USA
mRNA Vaccines Expressing Forms of RSV-F Protein Are Immunogenic and Protective in Preclinical Models of Respiratory Syncytial Virus Infection


Tuesday, February 12 | 5:00PM - 7:00PM
Clinical Results from Molecular-Based Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 5 of 7
Barney S. Graham, NIAID, National Institutes of Health, USA
Clinical Results from the Prefusion-Stabilized RSV F (DS-Cav1) Subunit Vaccine


Tuesday, February 12 | 5:00PM - 7:00PM
Clinical Results from Molecular-Based Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 6 of 7
Katherine Burgomaster, NIAID, National Institutes of Health, USA
Short Talk: Limited Cross-Reactive Antibody Responses Elicited by a ZIKV DNA Vaccine Candidate


Tuesday, February 12 | 5:00PM - 7:00PM
Clinical Results from Molecular-Based Vaccines
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 7 of 7
Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Short Talk: Enhanced Efficacy of Anti-Liver-Stage Vectored Vaccines using a Prime-Target Immunisation Approach


Tuesday, February 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, February 12 | 7:30PM - 10:00PM
Poster Session 2
Room: Colorado Rockies Ballroom


Wednesday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Wednesday, February 13 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 1 of 3
* Michel C. Nussenzweig, HHMI/Rockefeller University, USA

Wednesday, February 13 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 2 of 3
Facundo D. Batista, Massachusetts Institute of Technology and Harvard University, USA
Importance of B Cell-T Cell Interactions in Mouse Vaccine Models

Wednesday, February 13 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 3 of 3
Hedda Wardemann, German Cancer Research Center, Germany
Development and Clonal Evolution of Human Memory B Cell Antibody Responses

Wednesday, February 13 | 9:30AM - 10:00AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 13 | 10:00AM - 11:30AM
B Cell Responses in Infectious Disease
Room: Quandary Peak

Speaker 1 of 4
Patrick C. Wilson, University of Chicago, USA
The B Cell Response to Influenza and Vaccination

Wednesday, February 13 | 10:00AM - 11:30AM
B Cell Responses in Infectious Disease
Room: Quandary Peak

Speaker 2 of 4
Katherine Kedzierska, University of Melbourne, Australia
B Cell and T Follicular Helper Cell Responses during Influenza Virus Infection and Vaccination

Wednesday, February 13 | 10:00AM - 11:30AM
B Cell Responses in Infectious Disease
Room: Quandary Peak

Speaker 3 of 4
* Ian A. Cockburn, Australian National University, Australia
Short Talk: Chronic Antigen Exposure and Potent Antibody Feedback Limit Memory Responses to a Major Malaria Vaccine
Candidate


Wednesday, February 13 | 10:00AM - 11:30AM
B Cell Responses in Infectious Disease
Room: Quandary Peak

Speaker 4 of 4
Daniel Lingwood, Havard Medical School, USA
Short Talk: Natural Gene-Encoded Affinity for Cognate Antigen Facilitates Vaccine-Amplification of Broadly Neutralizing Antibodies against Influenza Virus

Wednesday, February 13 | 10:00AM - 11:45AM
Immune Monitoring of B Cell Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 1 of 7
* Brandon DeKosky, University of Kansas, USA


Wednesday, February 13 | 10:00AM - 11:45AM
Immune Monitoring of B Cell Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 2 of 7
* Frederick W. Alt, Boston Children's Hospital, USA


Wednesday, February 13 | 10:00AM - 11:45AM
Immune Monitoring of B Cell Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 3 of 7
Michael Joseph Mina, Brigham and Women's Hospital / Harvard Medical School / School of Public Health, USA
Comprehensive Profiling of the Anti-Pathogen Antibody Repertoire with Phage Display and Deep Neural Networks for Infectious Disease and Vaccine Surveillance


Wednesday, February 13 | 10:00AM - 11:45AM
Immune Monitoring of B Cell Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 4 of 7
Margaret E. Ackerman, Dartmouth College, USA
Measuring and Mining Serum Antibody Responses to Understand Protection from Infection


Wednesday, February 13 | 10:00AM - 11:45AM
Immune Monitoring of B Cell Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 5 of 7
Gwo-Yu Chuang, NIAID, National Institutes of Health, USA
Short Talk: Delineating the Sequence Signature of a Multi-Donor Class of Human Antibodies that Broadly Neutralizes Influenza Viruses for Immune Monitoring of Vaccination Studies


Wednesday, February 13 | 10:00AM - 11:45AM
Immune Monitoring of B Cell Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 6 of 7
Colin Havenar-Daughton, Vir Biotechnology, USA
Short Talk: Longitudinally Tracked, Rapid, Robust Antigen-Specific Germinal Center Responses and Somatic Hypermutation in
Non-Human Primates After a Single Nanoparticle Vaccine Immunization


Wednesday, February 13 | 10:00AM - 11:45AM
Immune Monitoring of B Cell Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 7 of 7
David B. Weiner, Wistar Institute, USA
Short Talk: Immunogenicity and Protection with A Low-Dose Intradermal Vaccine INO-4700 Against Middle East Respiratory
Syndrome in Non-Human Primates


Wednesday, February 13 | 11:30AM - 5:00PM
On Own for Lunch


Wednesday, February 13 | 11:45AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Wednesday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: B Cell-T Cell Interactions in Disease
Room: Quandary Peak

Speaker 1 of 8
Davide Angeletti, University of Gothenburg, Sweden
Outflanking B Cell and Antibody Immunodominance to Target Subdominant Influenza A Virus Epitopes

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: B Cell-T Cell Interactions in Disease
Room: Quandary Peak

Speaker 2 of 8
Rachael Bashford-Rogers, University of Oxford, UK
Mapping B Cell Receptor Repertoires in Six Immune-Mediated Diseases

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: B Cell-T Cell Interactions in Disease
Room: Quandary Peak

Speaker 3 of 8
Blair L. DeBuysscher, Fred Hutchinson Cancer Research Center, USA
Mapping the HIV Envelope-Specific B Cell Population in HIV-Unexposed Individuals

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: B Cell-T Cell Interactions in Disease
Room: Quandary Peak

Speaker 4 of 8
Marco De Giovanni, Ospedale San Raffaele Srl, Italy
Spatiotemporal Regulation of Type I Interferon Determines Antiviral CD4+ T Cell Polarization

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: B Cell-T Cell Interactions in Disease
Room: Quandary Peak

Speaker 5 of 8
* Joanna R. Groom, Walter and Eliza Hall Institute of Medical Research, Australia
TFH/TH1 Common Precursor Requires CXCR3-Dependent Interactions at the T:B Boarder

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: B Cell-T Cell Interactions in Disease
Room: Quandary Peak

Speaker 6 of 8
Shi-Hsia Hwa, Africa Health Research Institute, South Africa
Effects of Monoclonal Antibodies from TB Patient Lymph Node and Healthy Donor Blood on Mycobacterium tuberculosis Growth and Macrophage Infection

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: B Cell-T Cell Interactions in Disease
Room: Quandary Peak

Speaker 7 of 8
Amber Papillion, University of Alabama, USA
Interleukin 6 Prevents the Premature Contraction of the T Follicular Helper (Tfh) Cell Response to Influenza by Precluding IL-2 Responsiveness of GC-Tfh Cells

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: B Cell-T Cell Interactions in Disease
Room: Quandary Peak

Speaker 8 of 8
William T. Yewdell, Memorial Sloan Kettering Cancer Center, USA
Striking Features of the Memory B Cell Response to Influenza Infection

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: Molecular Probing of the Elicited Vaccine Respon
se
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 1 of 9
* George Georgiou, University of Texas at Austin, USA


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: Molecular Probing of the Elicited Vaccine Respon
se
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 2 of 9
* Pierre Bruhns, Institut Pasteur, France


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: Molecular Probing of the Elicited Vaccine Respon
se
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 3 of 9
Maryam Mukhamedova, NIAID, National Institutes of Health, USA
Characterization of RSV Antibody Repertoire to B Cells Elicited by Prefusion RSV F Subunit Protein (DS-Cav1)-Vaccinated Adult Volunteers


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: Molecular Probing of the Elicited Vaccine Respon
se
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 4 of 9
Raffaello Verardi, NIAID, National Institutes of Health, USA
Structural Studies of Human Norovirus Antibodies Isolated from Vaccines Reveal Basis for Broad Reactivity


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: Molecular Probing of the Elicited Vaccine Respon
se
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 5 of 9
Christopher A. Cottrell, The Scripps Research Institute, USA
Immunofocusing Antibody Responses to Target the HIV Env Fusion Peptide (FP) Epitope in Non-Human Primates (NHPs)


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: Molecular Probing of the Elicited Vaccine Respon
se
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 6 of 9
Zizhang Sheng, Columbia University, USA
Developmental Pathways for Vaccine-Induced Neutralizing Antibodies Targeting the HIV-1 Fusion Peptide Suggest a Low Barrier to Elicitation


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: Molecular Probing of the Elicited Vaccine Respon
se
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 7 of 9
Rajagopal Murugan, German Cancer Research Institute, Germany
Maturation of the Memory B Cell Response to Plasmodium Falciparum Circumsporozoite Protein (PfCSP) through
Clonal Selection, Not Affinity Maturation


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: Molecular Probing of the Elicited Vaccine Respon
se
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 8 of 9
Elisabetta Frigimelica, GlaxoSmithKline Vaccines S.r.l., Italy
Characterization of the Human Antibody Repertoire Following Immunization with Meningococcus B Vaccine


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 3: Molecular Probing of the Elicited Vaccine Respon
se
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 9 of 9
Murillo Silva, Massachusetts Institute of Technology, USA
Saponin-MPLA Nanoparticulate Adjuvants Alter Lymph Flow and Enhance Early Antigen Acquisition by B Cells


Wednesday, February 13 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 13 | 5:00PM - 7:00PM
Memory Humoral Responses
Room: Quandary Peak

Speaker 1 of 4
Marc K. Jenkins, University of Minnesota Medical School, USA
Memory T and B Cell Responses

Wednesday, February 13 | 5:00PM - 7:00PM
Memory Humoral Responses
Room: Quandary Peak

Speaker 2 of 4
Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Heterogeneity of Memory B Cell Compartments

Wednesday, February 13 | 5:00PM - 7:00PM
Memory Humoral Responses
Room: Quandary Peak

Speaker 3 of 4
Marion Pepper, University of Washington, USA
Memory B Cells in Plasmodium Infection

Wednesday, February 13 | 5:00PM - 7:00PM
Memory Humoral Responses
Room: Quandary Peak

Speaker 4 of 4
* Claude-Agnès Reynaud, Necker-Paris Medical School, France
Short Talk: A Splenic IgM Memory Subset Harboring Anti-Bacterial Specificities is Sustained from Persistent Mucosal Germinal Center Reactions

Wednesday, February 13 | 5:00PM - 7:00PM
Optimizing Vaccine Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 1 of 7
* Ian A. Wilson, The Scripps Research Institute, USA


Wednesday, February 13 | 5:00PM - 7:00PM
Optimizing Vaccine Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 2 of 7
* Peter D. Kwong, NIAID, National Institutes of Health, USA


Wednesday, February 13 | 5:00PM - 7:00PM
Optimizing Vaccine Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 3 of 7
Neil P. King, University of Washington, USA
Computational Design of Protein Nanomaterials for Next-Generation Vaccine Design


Wednesday, February 13 | 5:00PM - 7:00PM
Optimizing Vaccine Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 4 of 7
Günther Staffler, AFFiRiS AG, Austria
Towards a Heart Attack Vaccine: PCSK9 as a Immunogen


Wednesday, February 13 | 5:00PM - 7:00PM
Optimizing Vaccine Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 5 of 7
Pierre Bruhns, Institut Pasteur, France
Monitoring Plasmablast Responses at the Single Cell Level


Wednesday, February 13 | 5:00PM - 7:00PM
Optimizing Vaccine Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 6 of 7
Sonia M. Maciejewski, NIAID, National Institutes of Health, USA
Short Talk: Distinct Correlates of Protection Among Closely Related ZIKV DNA Vaccines Identify a Critical Role for Antibody
Quality Following Vaccination


Wednesday, February 13 | 5:00PM - 7:00PM
Optimizing Vaccine Responses
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 7 of 7
Kimberly M. Cirelli, La Jolla Institute for Immunology, USA
Short Talk: Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation
of Immunodominance


Wednesday, February 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, February 13 | 7:30PM - 10:00PM
Poster Session 3
Room: Colorado Rockies Ballroom


Thursday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Thursday, February 14 | 8:00AM - 11:00AM
Humoral Autoimmunity and Allergic Responses
Room: Quandary Peak

Speaker 1 of 7
Rachel Ettinger, Viela Bio, USA
VIB4920, a Novel CD40L Antagonist, Decreased Disease Activity and Improved Biomarkers of Immune Activation in a Phase 1b, Proof-of-Concept Study in Rheumatoid Arthritis

Thursday, February 14 | 8:00AM - 11:00AM
Humoral Autoimmunity and Allergic Responses
Room: Quandary Peak

Speaker 2 of 7
Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Epitope Spreading in Autoimmune Germinal Centers

Thursday, February 14 | 8:00AM - 11:00AM
Humoral Autoimmunity and Allergic Responses
Room: Quandary Peak


Coffee Break

Thursday, February 14 | 8:00AM - 11:00AM
Humoral Autoimmunity and Allergic Responses
Room: Quandary Peak

Speaker 4 of 7
* Maria A. Curotto de Lafaille, New York University School of Medicine, USA
Biology of IgE Affinity Maturation

Thursday, February 14 | 8:00AM - 11:00AM
Humoral Autoimmunity and Allergic Responses
Room: Quandary Peak

Speaker 5 of 7
Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Progression from Benign to Pathogenic Autoantibody by Somatic Mutation in a Rogue Clone: Single Cell RNA and DNA Sequencing

Thursday, February 14 | 8:00AM - 11:00AM
Humoral Autoimmunity and Allergic Responses
Room: Quandary Peak

Speaker 6 of 7
Fleur du Pre, University of Oslo and Oslo University Hospital, Norway
Short Talk: A Celiac Disease Patient-Derived Anti-TG2 Antibody Is not Tolerized in Mice

Thursday, February 14 | 8:00AM - 11:00AM
Humoral Autoimmunity and Allergic Responses
Room: Quandary Peak

Speaker 7 of 7
Brigette Boast, Australian National University, Australia
Short Talk: ARPC1B-/- Mice Suggest a New Role for DOCK8 in the Murine Germinal Center Response

Thursday, February 14 | 8:00AM - 11:15AM
Vaccines: Better, Faster and Less Expensive!
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 1 of 12
* Amy S. Espeseth, Merck & Co., USA


Thursday, February 14 | 8:00AM - 11:15AM
Vaccines: Better, Faster and Less Expensive!
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 2 of 12
* Barney S. Graham, NIAID, National Institutes of Health, USA


Thursday, February 14 | 8:00AM - 11:15AM
Vaccines: Better, Faster and Less Expensive!
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 3 of 12
Rino Rappuoli, GlaxoSmithKline Vaccines, Italy
Developing Vaccines against Pandemics and for the Developing World


Thursday, February 14 | 8:00AM - 11:15AM
Vaccines: Better, Faster and Less Expensive!
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 4 of 12
Laura M. Walker, Adimab LLC, USA
Generation of Broad and Potent Neutralizing Antibodies to Speed Pandemic Responses


Thursday, February 14 | 8:00AM - 11:15AM
Vaccines: Better, Faster and Less Expensive!
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak


Coffee Break


Thursday, February 14 | 8:00AM - 11:15AM
Vaccines: Better, Faster and Less Expensive!
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 6 of 12
* Jeffrey B. Ulmer, GlaxoSmithKline Vaccines, USA


Thursday, February 14 | 8:00AM - 11:15AM
Vaccines: Better, Faster and Less Expensive!
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 7 of 12
* David B. Weiner, Wistar Institute, USA


Thursday, February 14 | 8:00AM - 11:15AM
Vaccines: Better, Faster and Less Expensive!
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 8 of 12
Brandon DeKosky, University of Kansas, USA
Paired Heavy-Light Chain Sequencing and Display for Immune Monitoring of Vaccination and Natural Infection


Thursday, February 14 | 8:00AM - 11:15AM
Vaccines: Better, Faster and Less Expensive!
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 9 of 12
Julie Ledgerwood, NIAID, National Institutes of Health, USA
Immune Monitoring to Increase the Likelihood of Phase 2 Success


Thursday, February 14 | 8:00AM - 11:15AM
Vaccines: Better, Faster and Less Expensive!
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 10 of 12
Ami Patel, Wistar Institute, USA
Short Talk: Infection to Protection: An in vivo Approach for Rapid Delivery of DNA-Encoded Monoclonal Antibodies (DMAbs) Isolated Directly from Ebola Virus Disease Survivors and Other Infectious Diseases


Thursday, February 14 | 8:00AM - 11:15AM
Vaccines: Better, Faster and Less Expensive!
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 11 of 12
Julia Lederhofer, NIAID, National Institutes of Health, USA
Short Talk: Augmented Immune Responses by Co-Immunization of Commercial Seasonal Influenza Vaccine and the HA
Stem-Based Universal Influenza Vaccine Candidates


Thursday, February 14 | 8:00AM - 11:15AM
Vaccines: Better, Faster and Less Expensive!
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 12 of 12
Daniel R. Ellis, University of Washington, USA
Short Talk: Co-Display of Multiple Antigenic Variants on Computationally-Designed Protein Nanomaterials as a Versatile Vaccine Platform


Thursday, February 14 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, February 14 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 14 | 5:00PM - 6:45PM
T-Dependent B Cell Differentiation
Room: Quandary Peak

Speaker 1 of 4
Brian J. Laidlaw, University of California, San Francisco, USA
Short Talk: Transcriptional Regulation of Memory B Cell Development Following Viral Infection

Thursday, February 14 | 5:00PM - 6:45PM
T-Dependent B Cell Differentiation
Room: Quandary Peak

Speaker 2 of 4
Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Ikaros Prevents Autoimmunity by Promoting Anergy Induction and Restraining Toll-Like Receptor Signaling in B Cells

Thursday, February 14 | 5:00PM - 6:45PM
T-Dependent B Cell Differentiation
Room: Quandary Peak

Speaker 3 of 4
Robert Brink, Garvan Institute of Medical Research, Australia
Constant Region-Based Selection in the Germinal Center Reaction

Thursday, February 14 | 5:00PM - 6:45PM
T-Dependent B Cell Differentiation
Room: Quandary Peak

Speaker 4 of 4
* Kai-Michael Toellner, University of Birmingham, UK
Short Talk: CCL19/CCL21 Direct Memory B Cell Reentry in Reactive Lymph Nodes

Thursday, February 14 | 5:00PM - 6:45PM
Reducing Vaccine Risks and Costs
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 1 of 5
* Margaret E. Ackerman, Dartmouth College, USA


Thursday, February 14 | 5:00PM - 6:45PM
Reducing Vaccine Risks and Costs
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 2 of 5
* Rino Rappuoli, GlaxoSmithKline Vaccines, Italy


Thursday, February 14 | 5:00PM - 6:45PM
Reducing Vaccine Risks and Costs
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 3 of 5
Jeffrey B. Ulmer, GlaxoSmithKline Vaccines, USA
Molecular Approaches to Streamlining Vaccine Discovery and Development


Thursday, February 14 | 5:00PM - 6:45PM
Reducing Vaccine Risks and Costs
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 4 of 5
Drew Weissman, University of Pennsylvania, USA
Advantages of an mRNA Vaccine Approach


Thursday, February 14 | 5:00PM - 6:45PM
Reducing Vaccine Risks and Costs
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak

Speaker 5 of 5
Gary J. Nabel, Sanofi, USA
Innovation in Antibody Structure and Design to Optimize Protection and Improve Efficacy: Vaccine Implications


Thursday, February 14 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Quandary Peak


Thursday, February 14 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Vaccines & Imm Monitoring
Room: Grays/Longs Peak


Thursday, February 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, February 14 | 8:00PM - 11:00PM
Entertainment
Room: Colorado Rockies Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, February 14 | 8:00PM - 11:00PM
Cash Bar
Room: Colorado Rockies Ballroom


Friday, February 15 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.