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Web Desc
Framing the Response to Emerging Virus Infections
Organizer(s): Ralph A. Tripp, Suresh Mahalingam, John W. Lowenthal, Andrew G. Bean and Malik Peiris
Date: October 14 - 18, 2018
Location: Lee Shau Kee Lecture Centre, Centennial Campus University of Hong Kong, Pok Fu Lam, Hong Kong
Organized in collaboration with the Croucher Foundation and The University of Hong Kong
Summary of Meeting:
Emerging and re-emerging viruses have the potential to cause high morbidity and mortality and range from localized outbreaks to epidemics. Due to their emerging nature, most aspects of the biology and infectious potential of these viruses are poorly understood. Our continuing struggle to respond to a procession of pandemics including SARS, avian influenza, MERS, Ebola and more recently Zika, highlights key gaps in our knowledge and should serve to motivate our re-thinking on how we can better prepare and deal with future unknown viral threats. This meeting will focus on important areas such as surveillance, diagnostics and countermeasures and other important advances in new technologies and how they are being applied to research. Furthermore, we will discuss how to facilitate the translation of research, data and candidate treatments through the development pipeline in a timely and cost-effective manner. The key themes to be covered include the need to understand why zoonotic diseases matter, their association with agriculture, the importance of surveillance and early detection, and the difficulties of dealing with diseases that involve both medical and veterinary communities. The conference will bring together experts in virology, immunology, vaccinology, epidemiology with those that seek to transfer knowledge between these groups, veterinarians and industry and government. Further, this meeting would bring together individuals involved in the control of these diseases in government and non-government organizations, as well as people involved in study of zoonosis and countermeasures. The creation of global networks and sharing of information will ensure that we are better prepared for future outbreaks.
Global Health Travel Award Deadline: June 27 2018
Scholarship Deadline: June 27 2018
Discounted Abstract Deadline: June 27 2018
Abstract Deadline: July 17 2018
Discounted Registration Deadline: August 14 2018
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Croucher FoundationThe University of Hong Kong
We gratefully acknowledge additional support for this conference from:
GeneTex, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Takeda Pharmaceutical Company Limited
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI140574-01
Funding for this conference was made possible (in part) by 1 R13 AI140574-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, October 14 | 4:00PM - 8:00PM
Arrival and Registration
Room: Hotel Jen Lobby


Sunday, October 14 | 6:00PM - 8:00PM
Welcome Mixer
Room: Hotel Jen Lobby
No registration fees are used to fund alcohol served at this function.

Monday, October 15 | 8:00AM - 9:00AM
Poster Setup
Room: Lecture Hall LG 2


Monday, October 15 | 9:00AM - 5:30PM
Poster Viewing
Room: Lecture Hall LG 2


Monday, October 15 | 9:00AM - 10:00AM
Welcome and Keynote Address
Room: Grand Hall

Speaker 1 of 3
* Malik Peiris, University of Hong Kong, Hong Kong

Monday, October 15 | 9:00AM - 10:00AM
Welcome and Keynote Address
Room: Grand Hall

Speaker 2 of 3
Gabriel M. Leung, University of Hong Kong, Hong Kong
Opening Remarks

Monday, October 15 | 9:00AM - 10:00AM
Welcome and Keynote Address
Room: Grand Hall

Speaker 3 of 3
Peter Daszak, EcoHealth Alliance, USA
Emerging Infectious Disease Threats

Monday, October 15 | 10:00AM - 12:30PM
Mosquito-Borne Viruses - Biology and Host Interactions
Room: Grand Hall

Speaker 1 of 7
* Lisa E. Gralinski, University of North Carolina, USA

Monday, October 15 | 10:00AM - 12:30PM
Mosquito-Borne Viruses - Biology and Host Interactions
Room: Grand Hall

Speaker 2 of 7
Scott C. Weaver, University of Texas Medical Branch, USA
Urban Arboviruses: History, Evolution and Mechanisms of Emergence


Monday, October 15 | 10:00AM - 12:30PM
Mosquito-Borne Viruses - Biology and Host Interactions
Room: Grand Hall


Coffee Break

Monday, October 15 | 10:00AM - 12:30PM
Mosquito-Borne Viruses - Biology and Host Interactions
Room: Grand Hall

Speaker 4 of 7
Suresh Mahalingam, Griffith University, Australia
Alphavirus Inflammatory Disease Mechanisms and Approaches to Therapy

Monday, October 15 | 10:00AM - 12:30PM
Mosquito-Borne Viruses - Biology and Host Interactions
Room: Grand Hall

Speaker 5 of 7
Michael S. Diamond, Washington University School of Medicine, USA
Host Factors Required for Alphavirus Infection: The Identification of Mxra8 as an Entry Receptor

Monday, October 15 | 10:00AM - 12:30PM
Mosquito-Borne Viruses - Biology and Host Interactions
Room: Grand Hall

Speaker 6 of 7
Ali Zaid, Griffith University Gold Coast, Australia
Short Talk: Specific Inhibition of NLRP3 in Chikungunya Disease Reveals a Role for Inflammasome in Alphavirus-Induced
Inflammation


Monday, October 15 | 10:00AM - 12:30PM
Mosquito-Borne Viruses - Biology and Host Interactions
Room: Grand Hall

Speaker 7 of 7
Kar Muthumani, Wistar Institute, USA
Short Talk: Synthetic Nucleic Acid Antibody Prophylaxis + DNA Vaccine Confers Rapid and Durable Protective Immunity against Zika Virus

Monday, October 15 | 12:30PM - 1:30PM
Networking Lunch
Room: Lecture Hall LG 2


Monday, October 15 | 1:00PM - 3:00PM
Poster Session 1
Room: Lecture Hall LG 2


Monday, October 15 | 3:00PM - 3:30PM
Coffee Available
Room: Lecture Hall LG 2


Monday, October 15 | 3:30PM - 5:30PM
ZIKA Virus Countermeasures
Room: Grand Hall

Speaker 1 of 5
* Suresh Mahalingam, Griffith University, Australia

Monday, October 15 | 3:30PM - 5:30PM
ZIKA Virus Countermeasures
Room: Grand Hall

Speaker 2 of 5
Raman Rao, Takeda Pharmaceutical Company, Singapore
Zika Vaccine Development Strategies for Emergency Preparedness

Monday, October 15 | 3:30PM - 5:30PM
ZIKA Virus Countermeasures
Room: Grand Hall

Speaker 3 of 5
Mauro Martins Teixeira, Universidade Federal de Minas Gerais, Brazil
The Role of Glutamate Receptors in the Pathogenesis of Zika

Monday, October 15 | 3:30PM - 5:30PM
ZIKA Virus Countermeasures
Room: Grand Hall

Speaker 4 of 5
Natalie A. Prow, University of South Australia, Australia
A New Replication-Defective, Vaccinia-Derived, CHO-Manufactured Vaccine Vector System (SCV) Is Effective in
Preclinical Studies against Zika and Chikungunya Viruses


Monday, October 15 | 3:30PM - 5:30PM
ZIKA Virus Countermeasures
Room: Grand Hall

Speaker 5 of 5
Mingyuan Li, University of Hong Kong, Hong Kong
Short Talk: Activated ADP-Ribosylation Factor 4 (ARF4) Is Required for ZIKA Virus (ZIKV) Infectious Cycle

Tuesday, October 16 | 8:30AM - 9:00AM
Poster Setup
Room: Lecture Hall LG 2


Tuesday, October 16 | 9:00AM - 5:00PM
Poster Viewing
Room: Lecture Hall LG 2


Tuesday, October 16 | 9:00AM - 10:30AM
Ebola Virus: Biology and Host Interactions
Room: Grand Hall

Speaker 1 of 6
* Erica Ollmann Saphire, La Jolla Institute for Immunology, USA

Tuesday, October 16 | 9:00AM - 10:30AM
Ebola Virus: Biology and Host Interactions
Room: Grand Hall

Speaker 2 of 6
Yoshihiro Kawaoka, University of Wisconsin / University of Tokyo, USA
Human Ebola Virus Disease Pathogenesis Revealed by Multi-Platform ‘Omics Analysis

Tuesday, October 16 | 9:00AM - 10:30AM
Ebola Virus: Biology and Host Interactions
Room: Grand Hall

Speaker 3 of 6
Andrea Marzi, NIAID, National Institutes of Health, USA
Animal Models of Ebolaviruses

Tuesday, October 16 | 9:00AM - 10:30AM
Ebola Virus: Biology and Host Interactions
Room: Grand Hall

Speaker 4 of 6
Adam Joseph Hume, Boston University, USA
Short Talk: The Use of Minigenome Systems as Tools to “Fill in the Blanks” for Uncultured Emerging Viruses and Facilitate
Virus Rescue: A Lloviu Virus Case Study


Tuesday, October 16 | 9:00AM - 10:30AM
Ebola Virus: Biology and Host Interactions
Room: Grand Hall

Speaker 5 of 6
Beatriz Escudero Pérez, Bernhard Nocht Institute for Tropical Medicine, Germany
Short Talk: Comparative Pathogenesis of Ebola and Reston Virus in Humanized Mice

Tuesday, October 16 | 9:00AM - 10:30AM
Ebola Virus: Biology and Host Interactions
Room: Grand Hall


Coffee Break

Tuesday, October 16 | 10:50AM - 12:30PM
Ebola Virus: Vaccines and Therapeutics
Room: Grand Hall

Speaker 1 of 5
* Andrea Marzi, NIAID, National Institutes of Health, USA

Tuesday, October 16 | 10:50AM - 12:30PM
Ebola Virus: Vaccines and Therapeutics
Room: Grand Hall

Speaker 2 of 5
Erica Ollmann Saphire, La Jolla Institute for Immunology, USA
Structural Studies to Guide the Development of Broadly Reactive Antibodies Against Ebolaviruses and Lassa Virus

Tuesday, October 16 | 10:50AM - 12:30PM
Ebola Virus: Vaccines and Therapeutics
Room: Grand Hall

Speaker 3 of 5
John Misasi, NIAID, National Institutes of Health, USA
Short Talk: ChAd3-Based Ebola Vaccination Induces Protective Antibody Classes

Tuesday, October 16 | 10:50AM - 12:30PM
Ebola Virus: Vaccines and Therapeutics
Room: Grand Hall

Speaker 4 of 5
Sarah Elliott, Wistar Institute, USA
Short Talk: A Synthetic Micro-Consensus DNA Vaccine Induces Potent Immune Responses Against Diverse Strains of Marburgvirus

Tuesday, October 16 | 10:50AM - 12:30PM
Ebola Virus: Vaccines and Therapeutics
Room: Grand Hall

Speaker 5 of 5
Danielle P. Porter, Gilead Sciences, USA
Short Talk: Broad Spectrum Antiviral Remdesivir for the Treatment of Emerging Viral Infections with High Outbreak Potential

Tuesday, October 16 | 12:30PM - 1:30PM
Lunch
Room: Lecture Hall LG 2


Tuesday, October 16 | 1:00PM - 3:00PM
Poster Session 2
Room: Lecture Hall LG 2


Tuesday, October 16 | 2:30PM - 3:00PM
Coffee Available
Room: Lecture Hall LG 2


Tuesday, October 16 | 3:00PM - 5:00PM
Zoonotic Influenza and MERS
Room: Grand Hall

Speaker 1 of 6
* Andrew G. Bean, Commonwealth Scientific and Industrial Research Organization, Australia

Tuesday, October 16 | 3:00PM - 5:00PM
Zoonotic Influenza and MERS
Room: Grand Hall

Speaker 2 of 6
Yi Guan, University of Hong Kong, Hong Kong
Zoonotic Influenza Viruses from China: An Increasing Pandemic Threat?

Tuesday, October 16 | 3:00PM - 5:00PM
Zoonotic Influenza and MERS
Room: Grand Hall

Speaker 3 of 6
Bart L. Haagmans, Erasmus MC, Netherlands
MERS-Coronavirus: From Discovery to Intervention

Tuesday, October 16 | 3:00PM - 5:00PM
Zoonotic Influenza and MERS
Room: Grand Hall

Speaker 4 of 6
Malik Peiris, University of Hong Kong, Hong Kong
MERS-Coronaviruses in Africa - Is There a Zoonotic Threat?

Tuesday, October 16 | 3:00PM - 5:00PM
Zoonotic Influenza and MERS
Room: Grand Hall

Speaker 5 of 6
LaiGiea Nicole Seng, University of Hong Kong, Hong Kong
Short Talk: Virulence Determinants of Novel Influenza A (H7N9) Virus in Mammals

Tuesday, October 16 | 3:00PM - 5:00PM
Zoonotic Influenza and MERS
Room: Grand Hall

Speaker 6 of 6
Sabiha Jahan Akhee, University of Hong Kong, Hong Kong
Short Talk: Deubiquitylase OTUB1 Plays Critical Role in Influenza A Virus Infection and Immune Response

Tuesday, October 16 | 6:00PM - 6:30PM
Transportation to Optional Dinner


Tuesday, October 16 | 6:30PM - 9:30PM
Optional Dinner Gathering at Jumbo Kingdom


Wednesday, October 17 | 9:00AM - 12:30PM
MERS
Room: Grand Hall

Speaker 1 of 11
* John W. Lowenthal, Deakin University, Australia

Wednesday, October 17 | 9:00AM - 12:30PM
MERS
Room: Grand Hall

Speaker 2 of 11
KY Yuen, University of Hong Kong, Hong Kong
Host Cellular Protein Facilitating Viral Replication

Wednesday, October 17 | 9:00AM - 12:30PM
MERS
Room: Grand Hall

Speaker 3 of 11
Ralph S. Baric, University of North Carolina at Chapel Hill, USA
Rapid Response Strategies to Control Emerging Coronavirus Infections

Wednesday, October 17 | 9:00AM - 12:30PM
MERS
Room: Grand Hall

Speaker 4 of 11
Dong-Yan Jin, University of Hong Kong, Hong Kong
Short Talk: Suppression of Type I Interferon Production by Middle East Respiratory Syndrome Coronavirus ORF8b Accessory Protein through Interaction with HSP70 Chaperone

Wednesday, October 17 | 9:00AM - 12:30PM
MERS
Room: Grand Hall

Speaker 5 of 11
Lisa E. Gralinski, University of North Carolina, USA
Short Talk: Using a Reduced Complexity Cross to Identify Host Susceptibility Factors to SARS-CoV Infection

Wednesday, October 17 | 9:00AM - 12:30PM
MERS
Room: Grand Hall


Coffee Break

Wednesday, October 17 | 9:00AM - 12:30PM
MERS
Room: Grand Hall

Speaker 7 of 11
* Bart L. Haagmans, Erasmus MC, Netherlands

Wednesday, October 17 | 9:00AM - 12:30PM
MERS
Room: Grand Hall

Speaker 8 of 11
John W. Lowenthal, Deakin University, Australia
A Strategy for Developing a MERS Camel Vaccine in Order to Protect Humans

Wednesday, October 17 | 9:00AM - 12:30PM
MERS
Room: Grand Hall

Speaker 9 of 11
Jincun Zhao, Guangzhou Institute of Respiratory Disease, China
Immune Responses in MERS-CoV Infected Mice and Humans

Wednesday, October 17 | 9:00AM - 12:30PM
MERS
Room: Grand Hall

Speaker 10 of 11
Stalin Raj Victor, Indian Institute of Science Education and Research, India
Short Talk: Chimeric Camel-Human Heavy Chain Antibodies Protect Mice from MERS-CoV Infection

Wednesday, October 17 | 9:00AM - 12:30PM
MERS
Room: Grand Hall

Speaker 11 of 11
Neeltje van Doremalen, NIAID, National Institutes of Health, USA
Short Talk: The Omics of Sex-Specific MERS-CoV Severity in a Transgenic Mouse Model

Wednesday, October 17 | 12:30PM - 1:00PM
Poster Setup
Room: Lecture Hall LG 2


Wednesday, October 17 | 12:30PM - 5:00PM
On Own for Lunch and Recreation


Wednesday, October 17 | 1:00PM - 9:30PM
Poster Viewing
Room: Lecture Hall LG 2


Wednesday, October 17 | 4:30PM - 5:00PM
Coffee Available
Room: Lecture Hall LG 2


Wednesday, October 17 | 5:00PM - 7:00PM
Emerging Disease Detection and Surveillance
Room: Grand Hall

Speaker 1 of 5
Marion P.G. Koopmans, Erasmus MC, Netherlands
Challenges and Opportunities in Emerging Disease Detection

Wednesday, October 17 | 5:00PM - 7:00PM
Emerging Disease Detection and Surveillance
Room: Grand Hall

Speaker 2 of 5
Gavin J.D. Smith, Duke-NUS Medical School, Singapore
Surveillance for Risk Assessment and Prediction

Wednesday, October 17 | 5:00PM - 7:00PM
Emerging Disease Detection and Surveillance
Room: Grand Hall

Speaker 3 of 5
Linfa Wang, Duke-NUS Medical School, Singapore
From SARS to SADS: EIDs Caused by Bat Coronaviruses

Wednesday, October 17 | 5:00PM - 7:00PM
Emerging Disease Detection and Surveillance
Room: Grand Hall

Speaker 4 of 5
Anna Uehara, Duke-NUS Medical School, Singapore
Short Talk: Serologic Evidence of Bat Orthoreovirus in Singapore

Wednesday, October 17 | 5:00PM - 7:00PM
Emerging Disease Detection and Surveillance
Room: Grand Hall

Speaker 5 of 5
Kenrie Pui Yan Hui, University of Hong Kong, Hong Kong
Short Talk: Tropism and Pathogenesis of the Avian Influenza A/H7N9 Virus in ex vivo and in vitro Cultures of the Human Respiratory Tract and Human Airway Organoids

Wednesday, October 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Lecture Hall LG 2


Wednesday, October 17 | 7:30PM - 9:30PM
Poster Session 3
Room: Lecture Hall LG 2


Thursday, October 18 | 9:00AM - 12:00PM
Influenza: Immunity and Vaccines
Room: Grand Hall

Speaker 1 of 10
* Ralph A. Tripp, University of Georgia, USA

Thursday, October 18 | 9:00AM - 12:00PM
Influenza: Immunity and Vaccines
Room: Grand Hall

Speaker 2 of 10
Leo Poon, University of Hong Kong, Hong Kong
Universal Influenza Vaccines

Thursday, October 18 | 9:00AM - 12:00PM
Influenza: Immunity and Vaccines
Room: Grand Hall

Speaker 3 of 10
Andrew G. Bean, Commonwealth Scientific and Industrial Research Organization, Australia
Tailoring the Avian Host Immune Response for Enhanced Vaccine Production

Thursday, October 18 | 9:00AM - 12:00PM
Influenza: Immunity and Vaccines
Room: Grand Hall

Speaker 4 of 10
Sophie A. Valkenburg, University of Hong Kong, Hong Kong
Short Talk: ADCC Antibodies Are a Protective Immune Correlate in a Household Model of Influenza Transmission

Thursday, October 18 | 9:00AM - 12:00PM
Influenza: Immunity and Vaccines
Room: Grand Hall

Speaker 5 of 10
Matloob Husain, University of Otago, New Zealand
Short Talk: The Identification of Human Histone Deacetylases, HDAC1 and HDAC2 as Novel Anti-Influenza Viral Factors

Thursday, October 18 | 9:00AM - 12:00PM
Influenza: Immunity and Vaccines
Room: Grand Hall


Coffee Break

Thursday, October 18 | 9:00AM - 12:00PM
Influenza: Immunity and Vaccines
Room: Grand Hall

Speaker 7 of 10
* Linfa Wang, Duke-NUS Medical School, Singapore

Thursday, October 18 | 9:00AM - 12:00PM
Influenza: Immunity and Vaccines
Room: Grand Hall

Speaker 8 of 10
Ted M. Ross, University of Georgia, USA
Broadly Protective Influenza Vaccines: Protection Against Mismatched Strains


Thursday, October 18 | 9:00AM - 12:00PM
Influenza: Immunity and Vaccines
Room: Grand Hall

Speaker 9 of 10
Li-meng Yan, University of Hong Kong, Hong Kong
Short Talk: Combined Use of Live-Attenuated and Inactivated Influenza Vaccines to Enhance Heterosubtypic Protection

Thursday, October 18 | 9:00AM - 12:00PM
Influenza: Immunity and Vaccines
Room: Grand Hall

Speaker 10 of 10
Timothy Uyeki, Centers for Disease Control and Prevention, USA
Short Talk: Clinical Research Is a Major Gap in the Response to Emerging Respiratory Viral Infections

Thursday, October 18 | 12:00PM - 1:30PM
Lunch
Room: Lecture Hall LG 2


Thursday, October 18 | 1:30PM - 3:45PM
Vaccine and Therapeutic Strategies
Room: Grand Hall

Speaker 1 of 8
* Marion P.G. Koopmans, Erasmus MC, Netherlands

Thursday, October 18 | 1:30PM - 3:45PM
Vaccine and Therapeutic Strategies
Room: Grand Hall

Speaker 2 of 8
Stephen Whitehead, NIAID, National Institutes of Health, USA
Evaluation of Live Attenuated Vaccines for Dengue and Zika Viruses (and their Challenge Models)

Thursday, October 18 | 1:30PM - 3:45PM
Vaccine and Therapeutic Strategies
Room: Grand Hall

Speaker 3 of 8
Ralph A. Tripp, University of Georgia, USA
Novel Strategies to Improve Vaccine Yield

Thursday, October 18 | 1:30PM - 3:45PM
Vaccine and Therapeutic Strategies
Room: Grand Hall


Coffee Break

Thursday, October 18 | 1:30PM - 3:45PM
Vaccine and Therapeutic Strategies
Room: Grand Hall

Speaker 5 of 8
Adam Taylor, Griffith University, Australia
Short Talk: Novel Delivery of a Live-Attenuated Chikungunya Virus Vaccine Candidate

Thursday, October 18 | 1:30PM - 3:45PM
Vaccine and Therapeutic Strategies
Room: Grand Hall

Speaker 6 of 8
James Duehr, Icahn School of Medicine, USA
Short Talk: Characterization of Humoral Immunity Generated against Andes Virus GnGc

Thursday, October 18 | 1:30PM - 3:45PM
Vaccine and Therapeutic Strategies
Room: Grand Hall

Speaker 7 of 8
Danielle E. Anderson, Duke-NUS Medical School, Singapore
Short Talk: SEC61B Is a Cellular Host Factor Required for Mumps Virus Replication in Humans and Bats

Thursday, October 18 | 1:30PM - 3:45PM
Vaccine and Therapeutic Strategies
Room: Grand Hall

Speaker 8 of 8
Laura Riva, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Identification of Chemical Compounds Inhibiting Ebola Virus Replication

Thursday, October 18 | 3:45PM - 4:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Grand Hall


Thursday, October 18 | 5:30PM - 6:30PM
Social Hour
Room: Cafe Malacca, Hotel Jen


Thursday, October 18 | 6:30PM - 8:00PM
Buffet Dinner
Room: Cafe Malacca, Hotel Jen


Friday, October 19 | 10:24AM - 10:24AM
Departure


*Session Chair.