Web Desc
21st-Century Drug Discovery and Development for Global Health
Organizer(s): Ken Duncan, Elizabeth Winzeler and Lluís Ballell
Date: October 17 - 20, 2018
Location: Hotel Palace Berlin, Berlin, Germany
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Infectious diseases cause substantial morbidity and mortality in the developing world. The medicines available today are often inconvenient to use or result in side effects, and many are being lost to emerging drug resistance. There remains an urgent need to discover and develop the next generation of transformative medicines that are more efficacious, more highly targeted, and have a better safety profile. This will only be achieved through the application of state-of-the-art drug discovery tools, technologies and approaches. This meeting will focus on diseases caused by parasitic organisms and bacteria, including malaria, neglected tropical diseases, diarrheal disease and tuberculosis. The goals of this meeting are to improve understanding of the disease burden and challenges faced in developing new therapies, to highlight examples of progress towards new drug candidates, and to foster communication and collaboration among communities of researchers working in global health across the spectrum from research to the clinic. The meeting will be of interest to basic scientists as well as drug discovery and development experts wanting to gain a better understanding of the challenges and opportunities in global health.
Global Health Travel Award Deadline: May 15 2018
Scholarship Deadline: June 19 2018
Discounted Abstract Deadline: June 19 2018
Abstract Deadline: July 17 2018
Discounted Registration Deadline: August 16 2018
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

BioVersys AG

Intarcia Therapeutics, Inc.

Sirenas
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, October 17 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer 2nd Floor


Wednesday, October 17 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer 2nd Floor
No registration fees are used to fund alcohol served at this function.

Thursday, October 18 | 8:00AM - 9:50AM
New Therapeutics for Global Health
Room: Bordeaux I-II

Speaker 1 of 5
* Ken Duncan, Bill & Melinda Gates Foundation, USA

Thursday, October 18 | 8:00AM - 9:50AM
New Therapeutics for Global Health
Room: Bordeaux I-II

Speaker 2 of 5
Nathalie Strub Wourgaft, Drugs for Neglected Diseases Initiative, DNDi, Switzerland
Transformative New Therapies for Human African trypanosomiasis

Thursday, October 18 | 8:00AM - 9:50AM
New Therapeutics for Global Health
Room: Bordeaux I-II

Speaker 3 of 5
Thierry T. Diagana, Novartis Institute for Tropical Diseases, USA
Progress with the Clinical Development of Cipargamin (KAE609) and Ganaplacide (KAF156) for the Treatment of Malaria

Thursday, October 18 | 8:00AM - 9:50AM
New Therapeutics for Global Health
Room: Bordeaux I-II

Speaker 4 of 5
Lluis Ballell, GlaxoSmithKline, Spain
Global Health GSK R&D in Tres Cantos – Introducing GSK701 and GSK286
as Novel Preclinical Candidates against Malaria and TB


Thursday, October 18 | 8:00AM - 9:50AM
New Therapeutics for Global Health
Room: Bordeaux I-II

Speaker 5 of 5
Joseph D. Turner, Liverpool School of Tropical Medicine, UK
Short Talk: Novel Anti-Wolbachia Drugs as Short-Course Macrofilaricides for Onchocerciasis

Thursday, October 18 | 10:10AM - 12:00PM
Robust Target Validation - What Does it Mean?
Room: Bordeaux I-II

Speaker 1 of 5
* Anil Koul, Institute of Microbial Technology, India

Thursday, October 18 | 10:10AM - 12:00PM
Robust Target Validation - What Does it Mean?
Room: Bordeaux I-II

Speaker 2 of 5
Elizabeth A. Winzeler, University of California, San Diego, USA
Multidisciplinary Approaches to the Discovery of Chemoprotective Drugs and Targets for Malaria

Thursday, October 18 | 10:10AM - 12:00PM
Robust Target Validation - What Does it Mean?
Room: Bordeaux I-II

Speaker 3 of 5
Dirk Schnappinger, Weill Cornell Medical College, USA
Combining Chemical Probes and Genetic Knockdowns to Validate Drug Targets in Mycobacterium tuberculosis

Thursday, October 18 | 10:10AM - 12:00PM
Robust Target Validation - What Does it Mean?
Room: Bordeaux I-II

Speaker 4 of 5
Boris Striepen, University of Pennsylvania, USA
Using Molecular Genetics to Understand and Combat Cryptosporidium


Thursday, October 18 | 10:10AM - 12:00PM
Robust Target Validation - What Does it Mean?
Room: Bordeaux I-II

Speaker 5 of 5
Andrew Fraser, University of Toronto, Canada
Short Talk: Dissecting the Pathway for Rhodoquinone Biosynthesis in C. elegans: It all Starts at the Beginning

Thursday, October 18 | 12:00PM - 1:00PM
Transfer to Grand Challenges Event at Estrel Congress Center


Thursday, October 18 | 12:30PM - 1:30PM
Lunch with Grand Challenges
Room: Estrel Congress Ctr, Convention Hall I-A/B


Thursday, October 18 | 1:30PM - 4:00PM
Joint Keynote Session and Panel Discussion with Grand Challe
nges: Innovation in Drug Discovery
Room: Estrel Convention Hall II
Keynote
Ken Duncan, The Bill & Melinda Gates Foundation, USA

Spotlight Talk
Kelly Chibale, University of Cape Town, South Africa

Panel Discussion: Combatting Antimicrobial Resistance through Drug Discovery and Innovation
*Sally Davies, UK Department of Health, UK
Stephen Baker, University of Oxford, UK
Renu Swarup, Department of Biotechnology, India

Closing Keynote
Lynda Stuart, The Bill & Melinda Gates Foundation, USA
Thursday, October 18 | 4:00PM - 5:00PM
Networking and Welcome Mixer with Grand Challenges and Keyst
one Symposia
Room: Estrel Congress Ctr, Convention Hall I-A/B


Thursday, October 18 | 5:00PM - 6:00PM
Return Transfer to Hotel


Thursday, October 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Burgund I-III
No registration fees are used to fund alcohol served at this function.

Friday, October 19 | 8:00AM - 11:00AM
Importance of Chemical Diversity in Seeking New Leads
Room: Bordeaux I-II

Speaker 1 of 7
* Courtney Cortez Aldrich, University of Minnesota, USA

Friday, October 19 | 8:00AM - 11:00AM
Importance of Chemical Diversity in Seeking New Leads
Room: Bordeaux I-II

Speaker 2 of 7
Xiaopeng Bai, GlaxoSmithKline, USA
Experience with DNA-Encoded Libraries in Search for New Leads against TB

Friday, October 19 | 8:00AM - 11:00AM
Importance of Chemical Diversity in Seeking New Leads
Room: Bordeaux I-II

Speaker 3 of 7
E. Paige Stout, Sirenas, USA
Sirenas Biochemometrics Platform: Transforming the Search for New Medicines

Friday, October 19 | 8:00AM - 11:00AM
Importance of Chemical Diversity in Seeking New Leads
Room: Bordeaux I-II


Coffee Break

Friday, October 19 | 8:00AM - 11:00AM
Importance of Chemical Diversity in Seeking New Leads
Room: Bordeaux I-II

Speaker 5 of 7
Judy A. Sakanari, University of California, San Francisco, USA
Identifying Anti-Filarial Candidates using a Multifaceted Screening Funnel

Friday, October 19 | 8:00AM - 11:00AM
Importance of Chemical Diversity in Seeking New Leads
Room: Bordeaux I-II

Speaker 6 of 7
Charles E. Mowbray, Drugs for Neglected Diseases Initiative, Switzerland
A New Era of Orally Active Treatments for Leishmaniasis Patients

Friday, October 19 | 8:00AM - 11:00AM
Importance of Chemical Diversity in Seeking New Leads
Room: Bordeaux I-II

Speaker 7 of 7
Jennifer Elizabeth Collins, University of Central Florida, USA
Short Talk: Novel Antiplasmodial Compounds from Fungi

Friday, October 19 | 11:00AM - 5:00PM
On Own for Lunch


Friday, October 19 | 11:00AM - 1:00PM
Poster Setup
Room: Burgund I-III


Friday, October 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Burgund I-III


Friday, October 19 | 4:30PM - 5:00PM
Coffee Available
Room: Burgund I-III


Friday, October 19 | 5:00PM - 7:00PM
Alternative Approaches to Drug Delivery - Opportunities and
Challenges

Room: Bordeaux I-II

Speaker 1 of 5
* Anna Upton, TB Alliance, USA

Friday, October 19 | 5:00PM - 7:00PM
Alternative Approaches to Drug Delivery - Opportunities and
Challenges

Room: Bordeaux I-II

Speaker 2 of 5
Paul L. Feldman, Intarcia Therapeutics, USA
Application of the Intarcia Medici Drug Delivery SystemTM for Long-Acting HIV Prevention for Global Health

Friday, October 19 | 5:00PM - 7:00PM
Alternative Approaches to Drug Delivery - Opportunities and
Challenges

Room: Bordeaux I-II

Speaker 3 of 5
Andrew Martin Bellinger, Lyndra, USA
Development of Oral, Ultra Long-Lasting, Sustained Release Therapies in the Fight against Malaria and HIV

Friday, October 19 | 5:00PM - 7:00PM
Alternative Approaches to Drug Delivery - Opportunities and
Challenges

Room: Bordeaux I-II

Speaker 4 of 5
Arnab Chatterjee, Calibr at Scripps Research, USA
Chemoprophylaxis for Prevention of Malaria Infection

Friday, October 19 | 5:00PM - 7:00PM
Alternative Approaches to Drug Delivery - Opportunities and
Challenges

Room: Bordeaux I-II

Speaker 5 of 5
Daniel Greenwood, Francis Crick Institute, UK
Short Talk: Subcellular Antibiotic Visualisation Reveals a Dynamic Drug Reservoir in Mycobacterium tuberculosis-Infected Macrophages

Friday, October 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Burgund I-III
No registration fees are used to fund alcohol served at this function.

Friday, October 19 | 7:30PM - 10:00PM
Poster Session 1
Room: Burgund I-III


Saturday, October 20 | 7:00AM - 8:00AM
Poster Setup
Room: Burgund I-III


Saturday, October 20 | 8:00AM - 5:00PM
Poster Viewing
Room: Burgund I-III


Saturday, October 20 | 8:00AM - 11:15AM
Improving Target and Phenotypic-Based Approaches
Room: Bordeaux I-II

Speaker 1 of 9
* Tanya Parish, Infectious Disease Research Institute, USA

Saturday, October 20 | 8:00AM - 11:15AM
Improving Target and Phenotypic-Based Approaches
Room: Bordeaux I-II

Speaker 2 of 9
Leann M. Tilley, University of Melbourne, Australia
The Proteasome as a Target for New Antimalarial Drugs

Saturday, October 20 | 8:00AM - 11:15AM
Improving Target and Phenotypic-Based Approaches
Room: Bordeaux I-II

Speaker 3 of 9
Kirsten Hanson, University of Texas at San Antonio, USA
Profiling Compounds against Liver Stage Malaria

Saturday, October 20 | 8:00AM - 11:15AM
Improving Target and Phenotypic-Based Approaches
Room: Bordeaux I-II

Speaker 4 of 9
Beatriz Baragana, University of Dundee, UK
Short Talk: Lysyl tRNA Synthetase as a Drug Target in Apicomplexan Parasites

Saturday, October 20 | 8:00AM - 11:15AM
Improving Target and Phenotypic-Based Approaches
Room: Bordeaux I-II

Speaker 5 of 9
Nyssa Drinkwater, Monash University, Australia
Short Talk: Rational Design of a Multi-Target Antimalarial Compound with in vivo Activity

Saturday, October 20 | 8:00AM - 11:15AM
Improving Target and Phenotypic-Based Approaches
Room: Bordeaux I-II


Coffee Break

Saturday, October 20 | 8:00AM - 11:15AM
Improving Target and Phenotypic-Based Approaches
Room: Bordeaux I-II

Speaker 7 of 9
Deborah T. Hung, Broad Institute of MIT & Harvard, USA
Multiplex Screening of an M. tuberculosis Hypomorph Library Simultaneously Identifies Lead and Target

Saturday, October 20 | 8:00AM - 11:15AM
Improving Target and Phenotypic-Based Approaches
Room: Bordeaux I-II

Speaker 8 of 9
Marc Gitzinger, BioVersys AG, Switzerland
A SMARt Approach to Reversing Drug Resistance in TB and Deploying the Hidden Potential of Current TB Drugs

Saturday, October 20 | 8:00AM - 11:15AM
Improving Target and Phenotypic-Based Approaches
Room: Bordeaux I-II

Speaker 9 of 9
Bryan J. Berube, Infectious Disease Research Institute, USA
Short Talk: MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis Alone and in Combination with Electron-Transport Chain Inhibitors

Saturday, October 20 | 11:15AM - 12:30PM
Lunch
Room: Burgund I-III


Saturday, October 20 | 12:00PM - 2:30PM
Poster Session 2
Room: Burgund I-III


Saturday, October 20 | 2:30PM - 4:30PM
Workshop: Opportunities for Repurposing to Discover New Cand
idates or Mature Starting Points
Room: Bordeaux I-II

Speaker 1 of 9
* Elnaz Menhaji-Klotz, Bill & Melinda Gates Medical Research Institute, USA

Saturday, October 20 | 2:30PM - 4:30PM
Workshop: Opportunities for Repurposing to Discover New Cand
idates or Mature Starting Points
Room: Bordeaux I-II

Speaker 2 of 9
* Khisimuzi E. Mdluli, Bill & Melinda Gates Medical Research Institute, USA

Saturday, October 20 | 2:30PM - 4:30PM
Workshop: Opportunities for Repurposing to Discover New Cand
idates or Mature Starting Points
Room: Bordeaux I-II

Speaker 3 of 9
Oluyomi S. Adeyemi, Landmark University, Nigeria
Drug Repurposing and Screening of Libraries of Chemical Compounds to Identify New Anti-Parasitic Agents

Saturday, October 20 | 2:30PM - 4:30PM
Workshop: Opportunities for Repurposing to Discover New Cand
idates or Mature Starting Points
Room: Bordeaux I-II

Speaker 4 of 9
Samuel Arnold, University of Washington, USA
A Second Chance for Your Favorite Protozoan Target: Repositioning Opportunities for Treatment of Cryptosporidosis

Saturday, October 20 | 2:30PM - 4:30PM
Workshop: Opportunities for Repurposing to Discover New Cand
idates or Mature Starting Points
Room: Bordeaux I-II

Speaker 5 of 9
Giancarlo Biagini, Liverpool School of Tropical Medicine, UK
Antimalarial Pharmacology of Primaquine: Attempting to Solve a 70-Year-Old Puzzle

Saturday, October 20 | 2:30PM - 4:30PM
Workshop: Opportunities for Repurposing to Discover New Cand
idates or Mature Starting Points
Room: Bordeaux I-II

Speaker 6 of 9
Elena Fernandez Alvaro, GlaxoSmithKline, Spain
Repurposing Opportunities for the Treatment of MDR Bacterial Enteric Infections

Saturday, October 20 | 2:30PM - 4:30PM
Workshop: Opportunities for Repurposing to Discover New Cand
idates or Mature Starting Points
Room: Bordeaux I-II

Speaker 7 of 9
Malkeet Kumar, University of Cape Town, South Africa
Repositioning the Antihistamine Drug Astemizole as an Anti-Plasmodial Agent

Saturday, October 20 | 2:30PM - 4:30PM
Workshop: Opportunities for Repurposing to Discover New Cand
idates or Mature Starting Points
Room: Bordeaux I-II

Speaker 8 of 9
Rob Leurs, Vrije Universiteit Amsterdam, Netherlands
Parasite-Specific Cyclic Nucleotide Phosphodiesterase Inhibitors to Target Neglected Parasitic Diseases (PDE4NPD)

Saturday, October 20 | 2:30PM - 4:30PM
Workshop: Opportunities for Repurposing to Discover New Cand
idates or Mature Starting Points
Room: Bordeaux I-II

Speaker 9 of 9
Rose C. Lopeman, Aston University, UK
Faropenem and Clavulanate Exhibit Additive Effect against Mycobacterium abscessus in vitro

Saturday, October 20 | 4:30PM - 5:00PM
Coffee Available
Room: Burgund I-III


Saturday, October 20 | 5:00PM - 6:45PM
Translational Tools for Predicting Efficacy and Resistance
Room: Bordeaux I-II

Speaker 1 of 5
* Robert S. Wallis, Aurum Institute, South Africa

Saturday, October 20 | 5:00PM - 6:45PM
Translational Tools for Predicting Efficacy and Resistance
Room: Bordeaux I-II

Speaker 2 of 5
Wesley C. Van Voorhis, University of Washington, USA
Pharmacodynamic Modeling of Anti-Cryptosporidium Drug Efficacy

Saturday, October 20 | 5:00PM - 6:45PM
Translational Tools for Predicting Efficacy and Resistance
Room: Bordeaux I-II

Speaker 3 of 5
Yingda L. Xie, NIAID, National Institutes of Health, USA
Improving Phase 2a TB Drug Development Models through PET/CT Imaging (NexGen EBA)

Saturday, October 20 | 5:00PM - 6:45PM
Translational Tools for Predicting Efficacy and Resistance
Room: Bordeaux I-II

Speaker 4 of 5
Cristina Donini, Medicines for Malaria Venture, Switzerland
Role of Volunteer Infection Studies in Prioritizing the Next Generation of Clinical Candidates in Malaria

Saturday, October 20 | 5:00PM - 6:45PM
Translational Tools for Predicting Efficacy and Resistance
Room: Bordeaux I-II

Speaker 5 of 5
Thomas Spangenberg, Merck, Switzerland
Short Talk: Evaluation of the Pharmacokinetic-Pharmacodynamic Relationship of Praziquantel in the Schistosoma mansoni Mouse Model

Saturday, October 20 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Bordeaux I-II


Saturday, October 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Burgund I-III
No registration fees are used to fund alcohol served at this function.

Saturday, October 20 | 8:00PM - 11:00PM
Entertainment
Room: Burgund I-III
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Saturday, October 20 | 8:00PM - 11:00PM
Cash Bar
Room: Burgund I-III


Sunday, October 21 | 10:24AM - 10:24AM
Departure


*Session Chair.