Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Helminths: New Insights from Immunity to Global Health (2020T4)
The Malaria Endgame: Innovation in Therapeutics, Vector Control and Public Health Tools (2020G1)

Web Desc
21st-Century Drug Discovery and Development for Global Health Organizer(s): Ken Duncan, Elizabeth Winzeler and Lluís Ballell Date: October 17 - 20, 2018 Location: Hotel Palace Berlin, Berlin, Germany Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation Summary of Meeting: Infectious diseases cause substantial morbidity and mortality in the developing world. The medicines available today are often inconvenient to use or result in side effects, and many are being lost to emerging drug resistance. There remains an urgent need to discover and develop the next generation of transformative medicines that are more efficacious, more highly targeted, and have a better safety profile. This will only be achieved through the application of state-of-the-art drug discovery tools, technologies and approaches. This meeting will focus on diseases caused by parasitic organisms and bacteria, including malaria, neglected tropical diseases, diarrheal disease and tuberculosis. The goals of this meeting are to improve understanding of the disease burden and challenges faced in developing new therapies, to highlight examples of progress towards new drug candidates, and to foster communication and collaboration among communities of researchers working in global health across the spectrum from research to the clinic. The meeting will be of interest to basic scientists as well as drug discovery and development experts wanting to gain a better understanding of the challenges and opportunities in global health. Global Health Travel Award Deadline: May 15 2018 Scholarship Deadline: June 19 2018 Discounted Abstract Deadline: June 19 2018 Abstract Deadline: July 17 2018 Discounted Registration Deadline: August 16 2018 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: BioVersys AG Intarcia Therapeutics, Inc. Sirenas We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

21st-Century Drug Discovery and Development for Global Health

Organizer(s): Ken Duncan, Elizabeth Winzeler and Lluís Ballell

Date: October 17 - 20, 2018
Location: Hotel Palace Berlin, Berlin, Germany

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation

Summary of Meeting:

Infectious diseases cause substantial morbidity and mortality in the developing world. The medicines available today are often inconvenient to use or result in side effects, and many are being lost to emerging drug resistance. There remains an urgent need to discover and develop the next generation of transformative medicines that are more efficacious, more highly targeted, and have a better safety profile. This will only be achieved through the application of state-of-the-art drug discovery tools, technologies and approaches. This meeting will focus on diseases caused by parasitic organisms and bacteria, including malaria, neglected tropical diseases, diarrheal disease and tuberculosis. The goals of this meeting are to improve understanding of the disease burden and challenges faced in developing new therapies, to highlight examples of progress towards new drug candidates, and to foster communication and collaboration among communities of researchers working in global health across the spectrum from research to the clinic. The meeting will be of interest to basic scientists as well as drug discovery and development experts wanting to gain a better understanding of the challenges and opportunities in global health.

Global Health Travel Award Deadline: May 15 2018

Scholarship Deadline: June 19 2018

Discounted Abstract Deadline: June 19 2018

Abstract Deadline: July 17 2018

Discounted Registration Deadline: August 16 2018

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

BioVersys AG

Intarcia Therapeutics, Inc.

Sirenas

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Wednesday, October 17 \| 4:00PM - 8:00PM Arrival and Registration Room: Foyer 2nd Floor
Wednesday, October 17 \| 6:00PM - 8:00PM Welcome Mixer Room: Foyer 2nd Floor No registration fees are used to fund alcohol served at this function.
Thursday, October 18 \| 8:00AM - 9:50AM New Therapeutics for Global Health Room: Bordeaux I-II Speaker 1 of 5 * Ken Duncan, Bill & Melinda Gates Foundation, USA
Thursday, October 18 \| 8:00AM - 9:50AM New Therapeutics for Global Health Room: Bordeaux I-II Speaker 2 of 5 Nathalie Strub Wourgaft, Drugs for Neglected Diseases Initiative, DNDi, Switzerland Transformative New Therapies for Human African trypanosomiasis
Thursday, October 18 \| 8:00AM - 9:50AM New Therapeutics for Global Health Room: Bordeaux I-II Speaker 3 of 5 Thierry T. Diagana, Novartis Institute for Tropical Diseases, USA Progress with the Clinical Development of Cipargamin (KAE609) and Ganaplacide (KAF156) for the Treatment of Malaria
Thursday, October 18 \| 8:00AM - 9:50AM New Therapeutics for Global Health Room: Bordeaux I-II Speaker 4 of 5 Lluis Ballell, GlaxoSmithKline, Spain Global Health GSK R&D in Tres Cantos – Introducing GSK701 and GSK286 as Novel Preclinical Candidates against Malaria and TB
Thursday, October 18 \| 8:00AM - 9:50AM New Therapeutics for Global Health Room: Bordeaux I-II Speaker 5 of 5 Joseph D. Turner, Liverpool School of Tropical Medicine, UK Short Talk: Novel Anti-Wolbachia Drugs as Short-Course Macrofilaricides for Onchocerciasis
Thursday, October 18 \| 10:10AM - 12:00PM Robust Target Validation - What Does it Mean? Room: Bordeaux I-II Speaker 1 of 5 * Anil Koul, Institute of Microbial Technology, India
Thursday, October 18 \| 10:10AM - 12:00PM Robust Target Validation - What Does it Mean? Room: Bordeaux I-II Speaker 2 of 5 Elizabeth A. Winzeler, University of California, San Diego, USA Multidisciplinary Approaches to the Discovery of Chemoprotective Drugs and Targets for Malaria
Thursday, October 18 \| 10:10AM - 12:00PM Robust Target Validation - What Does it Mean? Room: Bordeaux I-II Speaker 3 of 5 Dirk Schnappinger, Weill Cornell Medical College, USA Combining Chemical Probes and Genetic Knockdowns to Validate Drug Targets in Mycobacterium tuberculosis
Thursday, October 18 \| 10:10AM - 12:00PM Robust Target Validation - What Does it Mean? Room: Bordeaux I-II Speaker 4 of 5 Boris Striepen, University of Pennsylvania, USA Using Molecular Genetics to Understand and Combat Cryptosporidium
Thursday, October 18 \| 10:10AM - 12:00PM Robust Target Validation - What Does it Mean? Room: Bordeaux I-II Speaker 5 of 5 Andrew Fraser, University of Toronto, Canada Short Talk: Dissecting the Pathway for Rhodoquinone Biosynthesis in C. elegans: It all Starts at the Beginning
Thursday, October 18 \| 12:00PM - 1:00PM Transfer to Grand Challenges Event at Estrel Congress Center
Thursday, October 18 \| 12:30PM - 1:30PM Lunch with Grand Challenges Room: Estrel Congress Ctr, Convention Hall I-A/B
Thursday, October 18 \| 1:30PM - 4:00PM Joint Keynote Session and Panel Discussion with Grand Challe nges: Innovation in Drug Discovery Room: Estrel Convention Hall II Keynote Ken Duncan, The Bill & Melinda Gates Foundation, USA Spotlight Talk Kelly Chibale, University of Cape Town, South Africa Panel Discussion: Combatting Antimicrobial Resistance through Drug Discovery and Innovation *Sally Davies, UK Department of Health, UK Stephen Baker, University of Oxford, UK Renu Swarup, Department of Biotechnology, India Closing Keynote Lynda Stuart, The Bill & Melinda Gates Foundation, USA
Thursday, October 18 \| 4:00PM - 5:00PM Networking and Welcome Mixer with Grand Challenges and Keyst one Symposia Room: Estrel Congress Ctr, Convention Hall I-A/B
Thursday, October 18 \| 5:00PM - 6:00PM Return Transfer to Hotel
Thursday, October 18 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Burgund I-III No registration fees are used to fund alcohol served at this function.
Friday, October 19 \| 8:00AM - 11:00AM Importance of Chemical Diversity in Seeking New Leads Room: Bordeaux I-II Speaker 1 of 7 * Courtney Cortez Aldrich, University of Minnesota, USA
Friday, October 19 \| 8:00AM - 11:00AM Importance of Chemical Diversity in Seeking New Leads Room: Bordeaux I-II Speaker 2 of 7 Xiaopeng Bai, GlaxoSmithKline, USA Experience with DNA-Encoded Libraries in Search for New Leads against TB
Friday, October 19 \| 8:00AM - 11:00AM Importance of Chemical Diversity in Seeking New Leads Room: Bordeaux I-II Speaker 3 of 7 E. Paige Stout, Sirenas, USA Sirenas Biochemometrics Platform: Transforming the Search for New Medicines
Friday, October 19 \| 8:00AM - 11:00AM Importance of Chemical Diversity in Seeking New Leads Room: Bordeaux I-II Coffee Break
Friday, October 19 \| 8:00AM - 11:00AM Importance of Chemical Diversity in Seeking New Leads Room: Bordeaux I-II Speaker 5 of 7 Judy A. Sakanari, University of California, San Francisco, USA Identifying Anti-Filarial Candidates using a Multifaceted Screening Funnel
Friday, October 19 \| 8:00AM - 11:00AM Importance of Chemical Diversity in Seeking New Leads Room: Bordeaux I-II Speaker 6 of 7 Charles E. Mowbray, Drugs for Neglected Diseases Initiative, Switzerland A New Era of Orally Active Treatments for Leishmaniasis Patients
Friday, October 19 \| 8:00AM - 11:00AM Importance of Chemical Diversity in Seeking New Leads Room: Bordeaux I-II Speaker 7 of 7 Jennifer Elizabeth Collins, University of Central Florida, USA Short Talk: Novel Antiplasmodial Compounds from Fungi
Friday, October 19 \| 11:00AM - 5:00PM On Own for Lunch
Friday, October 19 \| 11:00AM - 1:00PM Poster Setup Room: Burgund I-III
Friday, October 19 \| 1:00PM - 10:00PM Poster Viewing Room: Burgund I-III
Friday, October 19 \| 4:30PM - 5:00PM Coffee Available Room: Burgund I-III
Friday, October 19 \| 5:00PM - 7:00PM Alternative Approaches to Drug Delivery - Opportunities and Challenges Room: Bordeaux I-II Speaker 1 of 5 * Anna Upton, TB Alliance, USA
Friday, October 19 \| 5:00PM - 7:00PM Alternative Approaches to Drug Delivery - Opportunities and Challenges Room: Bordeaux I-II Speaker 2 of 5 Paul L. Feldman, Intarcia Therapeutics, USA Application of the Intarcia Medici Drug Delivery SystemTM for Long-Acting HIV Prevention for Global Health
Friday, October 19 \| 5:00PM - 7:00PM Alternative Approaches to Drug Delivery - Opportunities and Challenges Room: Bordeaux I-II Speaker 3 of 5 Andrew Martin Bellinger, Lyndra, USA Development of Oral, Ultra Long-Lasting, Sustained Release Therapies in the Fight against Malaria and HIV
Friday, October 19 \| 5:00PM - 7:00PM Alternative Approaches to Drug Delivery - Opportunities and Challenges Room: Bordeaux I-II Speaker 4 of 5 Arnab Chatterjee, Calibr at Scripps Research, USA Chemoprophylaxis for Prevention of Malaria Infection
Friday, October 19 \| 5:00PM - 7:00PM Alternative Approaches to Drug Delivery - Opportunities and Challenges Room: Bordeaux I-II Speaker 5 of 5 Daniel Greenwood, Francis Crick Institute, UK Short Talk: Subcellular Antibiotic Visualisation Reveals a Dynamic Drug Reservoir in Mycobacterium tuberculosis-Infected Macrophages
Friday, October 19 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Burgund I-III No registration fees are used to fund alcohol served at this function.
Friday, October 19 \| 7:30PM - 10:00PM Poster Session 1 Room: Burgund I-III
Saturday, October 20 \| 7:00AM - 8:00AM Poster Setup Room: Burgund I-III
Saturday, October 20 \| 8:00AM - 5:00PM Poster Viewing Room: Burgund I-III
Saturday, October 20 \| 8:00AM - 11:15AM Improving Target and Phenotypic-Based Approaches Room: Bordeaux I-II Speaker 1 of 9 * Tanya Parish, Infectious Disease Research Institute, USA
Saturday, October 20 \| 8:00AM - 11:15AM Improving Target and Phenotypic-Based Approaches Room: Bordeaux I-II Speaker 2 of 9 Leann M. Tilley, University of Melbourne, Australia The Proteasome as a Target for New Antimalarial Drugs
Saturday, October 20 \| 8:00AM - 11:15AM Improving Target and Phenotypic-Based Approaches Room: Bordeaux I-II Speaker 3 of 9 Kirsten Hanson, University of Texas at San Antonio, USA Profiling Compounds against Liver Stage Malaria
Saturday, October 20 \| 8:00AM - 11:15AM Improving Target and Phenotypic-Based Approaches Room: Bordeaux I-II Speaker 4 of 9 Beatriz Baragana, University of Dundee, UK Short Talk: Lysyl tRNA Synthetase as a Drug Target in Apicomplexan Parasites
Saturday, October 20 \| 8:00AM - 11:15AM Improving Target and Phenotypic-Based Approaches Room: Bordeaux I-II Speaker 5 of 9 Nyssa Drinkwater, Monash University, Australia Short Talk: Rational Design of a Multi-Target Antimalarial Compound with in vivo Activity
Saturday, October 20 \| 8:00AM - 11:15AM Improving Target and Phenotypic-Based Approaches Room: Bordeaux I-II Coffee Break
Saturday, October 20 \| 8:00AM - 11:15AM Improving Target and Phenotypic-Based Approaches Room: Bordeaux I-II Speaker 7 of 9 Deborah T. Hung, Broad Institute of MIT & Harvard, USA Multiplex Screening of an M. tuberculosis Hypomorph Library Simultaneously Identifies Lead and Target
Saturday, October 20 \| 8:00AM - 11:15AM Improving Target and Phenotypic-Based Approaches Room: Bordeaux I-II Speaker 8 of 9 Marc Gitzinger, BioVersys AG, Switzerland A SMARt Approach to Reversing Drug Resistance in TB and Deploying the Hidden Potential of Current TB Drugs
Saturday, October 20 \| 8:00AM - 11:15AM Improving Target and Phenotypic-Based Approaches Room: Bordeaux I-II Speaker 9 of 9 Bryan J. Berube, Infectious Disease Research Institute, USA Short Talk: MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis Alone and in Combination with Electron-Transport Chain Inhibitors
Saturday, October 20 \| 11:15AM - 12:30PM Lunch Room: Burgund I-III
Saturday, October 20 \| 12:00PM - 2:30PM Poster Session 2 Room: Burgund I-III
Saturday, October 20 \| 2:30PM - 4:30PM Workshop: Opportunities for Repurposing to Discover New Cand idates or Mature Starting Points Room: Bordeaux I-II Speaker 1 of 9 * Elnaz Menhaji-Klotz, Bill & Melinda Gates Medical Research Institute, USA
Saturday, October 20 \| 2:30PM - 4:30PM Workshop: Opportunities for Repurposing to Discover New Cand idates or Mature Starting Points Room: Bordeaux I-II Speaker 2 of 9 * Khisimuzi E. Mdluli, Bill & Melinda Gates Medical Research Institute, USA
Saturday, October 20 \| 2:30PM - 4:30PM Workshop: Opportunities for Repurposing to Discover New Cand idates or Mature Starting Points Room: Bordeaux I-II Speaker 3 of 9 Oluyomi S. Adeyemi, Landmark University, Nigeria Drug Repurposing and Screening of Libraries of Chemical Compounds to Identify New Anti-Parasitic Agents
Saturday, October 20 \| 2:30PM - 4:30PM Workshop: Opportunities for Repurposing to Discover New Cand idates or Mature Starting Points Room: Bordeaux I-II Speaker 4 of 9 Samuel Arnold, University of Washington, USA A Second Chance for Your Favorite Protozoan Target: Repositioning Opportunities for Treatment of Cryptosporidosis
Saturday, October 20 \| 2:30PM - 4:30PM Workshop: Opportunities for Repurposing to Discover New Cand idates or Mature Starting Points Room: Bordeaux I-II Speaker 5 of 9 Giancarlo Biagini, Liverpool School of Tropical Medicine, UK Antimalarial Pharmacology of Primaquine: Attempting to Solve a 70-Year-Old Puzzle
Saturday, October 20 \| 2:30PM - 4:30PM Workshop: Opportunities for Repurposing to Discover New Cand idates or Mature Starting Points Room: Bordeaux I-II Speaker 6 of 9 Elena Fernandez Alvaro, GlaxoSmithKline, Spain Repurposing Opportunities for the Treatment of MDR Bacterial Enteric Infections
Saturday, October 20 \| 2:30PM - 4:30PM Workshop: Opportunities for Repurposing to Discover New Cand idates or Mature Starting Points Room: Bordeaux I-II Speaker 7 of 9 Malkeet Kumar, University of Cape Town, South Africa Repositioning the Antihistamine Drug Astemizole as an Anti-Plasmodial Agent
Saturday, October 20 \| 2:30PM - 4:30PM Workshop: Opportunities for Repurposing to Discover New Cand idates or Mature Starting Points Room: Bordeaux I-II Speaker 8 of 9 Rob Leurs, Vrije Universiteit Amsterdam, Netherlands Parasite-Specific Cyclic Nucleotide Phosphodiesterase Inhibitors to Target Neglected Parasitic Diseases (PDE4NPD)
Saturday, October 20 \| 2:30PM - 4:30PM Workshop: Opportunities for Repurposing to Discover New Cand idates or Mature Starting Points Room: Bordeaux I-II Speaker 9 of 9 Rose C. Lopeman, Aston University, UK Faropenem and Clavulanate Exhibit Additive Effect against Mycobacterium abscessus in vitro
Saturday, October 20 \| 4:30PM - 5:00PM Coffee Available Room: Burgund I-III
Saturday, October 20 \| 5:00PM - 6:45PM Translational Tools for Predicting Efficacy and Resistance Room: Bordeaux I-II Speaker 1 of 5 * Robert S. Wallis, Aurum Institute, South Africa
Saturday, October 20 \| 5:00PM - 6:45PM Translational Tools for Predicting Efficacy and Resistance Room: Bordeaux I-II Speaker 2 of 5 Wesley C. Van Voorhis, University of Washington, USA Pharmacodynamic Modeling of Anti-Cryptosporidium Drug Efficacy
Saturday, October 20 \| 5:00PM - 6:45PM Translational Tools for Predicting Efficacy and Resistance Room: Bordeaux I-II Speaker 3 of 5 Yingda L. Xie, NIAID, National Institutes of Health, USA Improving Phase 2a TB Drug Development Models through PET/CT Imaging (NexGen EBA)
Saturday, October 20 \| 5:00PM - 6:45PM Translational Tools for Predicting Efficacy and Resistance Room: Bordeaux I-II Speaker 4 of 5 Cristina Donini, Medicines for Malaria Venture, Switzerland Role of Volunteer Infection Studies in Prioritizing the Next Generation of Clinical Candidates in Malaria
Saturday, October 20 \| 5:00PM - 6:45PM Translational Tools for Predicting Efficacy and Resistance Room: Bordeaux I-II Speaker 5 of 5 Thomas Spangenberg, Merck, Switzerland Short Talk: Evaluation of the Pharmacokinetic-Pharmacodynamic Relationship of Praziquantel in the Schistosoma mansoni Mouse Model
Saturday, October 20 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Bordeaux I-II
Saturday, October 20 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Burgund I-III No registration fees are used to fund alcohol served at this function.
Saturday, October 20 \| 8:00PM - 11:00PM Entertainment Room: Burgund I-III Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Saturday, October 20 \| 8:00PM - 11:00PM Cash Bar Room: Burgund I-III
Sunday, October 21 \| 10:24AM - 10:24AM Departure *Session Chair.