Web Desc
Unraveling the Secrets of Kidney Disease
joint with Diabetes: Innovations, Outcomes and Personalized Therapies
Organizer(s): Katalin Susztak, Caroline Fox and Masaomi Nangaku
Date: March 03 - 07, 2019
Location: Whistler Conference Centre, Whistler, BC, Canada
Sponsored by Akebia Therapeutics, Bayer AG and Vertex Pharmaceuticals Incorporated
Summary of Meeting:
Approximately one in 11 people in the world suffers from kidney disease. The incidence of kidney disease is increasing, especially in the developing world. This issue was recently reviewed and emphasized in a Lancet article (Global Health Atlas). Acute and chronic kidney disease is associated with a highly significant increase in cardiovascular death. Chronic kidney disease (CKD) represents a leading cause of death in the United States. There is no cure for this disease, with current treatment strategies relying on blood pressure control through blockade of the renin-angiotensin system. Such approaches only delay the development of end-stage kidney disease and can be associated with serious side effects. Recent identification of several novel mechanisms contributing to CKD development - including vascular changes, loss of podocytes and renal epithelial cells, matrix deposition, inflammation and metabolic dysregulation - has revealed new potential therapeutic approaches for CKD. This conference will review clinical and observational studies in the kidney disease area, highlight recent advances in basic biology of kidney and kidney disease, assess emerging strategies and agents for CKD treatment, and discuss major obstacles in drug development. The conference will also encourage collaborations among clinicians and researchers from academic institutes and pharmaceutical laboratories to accelerate innovation in this field. There has not been a conference in the area in kidney disease that brings together clinicians, basic scientists and industry to foster collaboration. Small focused conferences have been organized by the International Society of Nephrology, but these conferences are limited to a single special topic. Furthermore, more than half of kidney disease is caused by diabetes; pairing the conference with a conference focused on diabetes affords the opportunity to understand the role of diabetes in the development of kidney complications.
Scholarship Deadline: November 19 2018
Discounted Abstract Deadline: November 19 2018
Abstract Deadline: December 19 2018
Discounted Registration Deadline: January 11 2019
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Akebia TherapeuticsBayer AGVertex Pharmaceuticals Incorporated
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Boehringer Ingelheim Pharmaceuticals, Inc.

Regeneron Genetics Center, LLC
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK120137-01
Funding for this conference was made possible (in part) by 1R13DK120137-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 03 | 4:00PM - 8:00PM
Arrival and Registration
Room: Grand Foyer


Sunday, March 03 | 6:00PM - 8:00PM
Welcome Mixer
Room: Grand Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Grand Foyer


Monday, March 04 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky C

Speaker 1 of 3
* Masaomi Nangaku, University of Tokyo School of Medicine, Japan

Monday, March 04 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky C

Speaker 2 of 3
* Katalin Susztak, University of Pennsylvania, USA

Monday, March 04 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky C

Speaker 3 of 3
Caroline S. Fox, Merck Research Labs, USA
Using Genetics to Drive Drug Discovery: The Industry Perspective

Monday, March 04 | 8:00AM - 10:30AM
State of the Union for Diabetes Care anno 2019: What Should
We Expect from a Stellar Novel Diabetes Drug?
This session is from Diabetes Therapies

Room: Sea to Sky B

Speaker 1 of 6
* Philip J. Larsen, Bayer Pharmaceuticals, Germany


Monday, March 04 | 8:00AM - 10:30AM
State of the Union for Diabetes Care anno 2019: What Should
We Expect from a Stellar Novel Diabetes Drug?
This session is from Diabetes Therapies

Room: Sea to Sky B

Speaker 2 of 6
Tina Vilsbøll, Steno Diabetes Center Copenhagen, Denmark
How to Demonstrate Medical Value for Diabetes Drugs Fast and Convincingly


Monday, March 04 | 8:00AM - 10:30AM
State of the Union for Diabetes Care anno 2019: What Should
We Expect from a Stellar Novel Diabetes Drug?
This session is from Diabetes Therapies

Room: Sea to Sky B

Speaker 3 of 6
Brian Finan, Novo Nordisk, USA
Mechanisms of GIP Induced Augmentation of GLP-1 Pharmacology


Monday, March 04 | 8:00AM - 10:30AM
State of the Union for Diabetes Care anno 2019: What Should
We Expect from a Stellar Novel Diabetes Drug?
This session is from Diabetes Therapies

Room: Sea to Sky B


Coffee Break


Monday, March 04 | 8:00AM - 10:30AM
State of the Union for Diabetes Care anno 2019: What Should
We Expect from a Stellar Novel Diabetes Drug?
This session is from Diabetes Therapies

Room: Sea to Sky B

Speaker 5 of 6
Niels Porksen, Sanofi, France
Insulin Therapy: A Corner Stone of Diabetes Therapy, But is There Still Room for Innovation


Monday, March 04 | 8:00AM - 10:30AM
State of the Union for Diabetes Care anno 2019: What Should
We Expect from a Stellar Novel Diabetes Drug?
This session is from Diabetes Therapies

Room: Sea to Sky B

Speaker 6 of 6
George L. King, Joslin Diabetes Center, USA
Identification of Protective Factors against Nephropathy and Retinopathy in People with Diabetes of Extreme Duration


Monday, March 04 | 9:00AM - 12:00PM
Why Podocytes Are So Important in Kidney Disease?
Room: Sea to Sky C

Speaker 1 of 10
* Hermann Haller, Hannover Medical School, Germany

Monday, March 04 | 9:00AM - 12:00PM
Why Podocytes Are So Important in Kidney Disease?
Room: Sea to Sky C

Speaker 2 of 10
* Reiko Inagi, University of Tokyo School of Medicine, Japan

Monday, March 04 | 9:00AM - 12:00PM
Why Podocytes Are So Important in Kidney Disease?
Room: Sea to Sky C

Speaker 3 of 10
Friedhelm Hildebrandt, Boston Children’s Hospital, Harvard Medical School, USA
Monogenic Causes of Podocyte Loss Reveal Targets for Personalized Treatment

Monday, March 04 | 9:00AM - 12:00PM
Why Podocytes Are So Important in Kidney Disease?
Room: Sea to Sky C


Coffee Break

Monday, March 04 | 9:00AM - 12:00PM
Why Podocytes Are So Important in Kidney Disease?
Room: Sea to Sky C

Speaker 5 of 10
John Cijiang He, Icahn School of Medicine at Mount Sinai, USA
Potential New Therapies by Targeting on Podocyte Injury

Monday, March 04 | 9:00AM - 12:00PM
Why Podocytes Are So Important in Kidney Disease?
Room: Sea to Sky C

Speaker 6 of 10
Stuart J. Shankland, University of Washington, USA
Understanding Podocyte Regeneration

Monday, March 04 | 9:00AM - 12:00PM
Why Podocytes Are So Important in Kidney Disease?
Room: Sea to Sky C

Speaker 7 of 10
Kyung Lee, Icahn School of Medicine at Mount Sinai, USA
Short Talk: BAMBI Protects against Podocyte and Endothelial Cell Injury in Diabetic Kidneys through Two Distinct TGF-ß Signaling Pathways

Monday, March 04 | 9:00AM - 12:00PM
Why Podocytes Are So Important in Kidney Disease?
Room: Sea to Sky C

Speaker 8 of 10
Markus M. Rinschen, The Scripps Research Institute, USA
Short Talk: Phenotype-Guided Ultrasensitive Proteomics for Discovery of Conserved Injury Mechanisms in Podocytes and Nephrocytes

Monday, March 04 | 9:00AM - 12:00PM
Why Podocytes Are So Important in Kidney Disease?
Room: Sea to Sky C

Speaker 9 of 10
Shizheng Huang, University of Pennsylvania, USA
Short Talk: Allele-Specific Expression Studies Identify Tubule Epithelial DACH1 as a Kidney Disease Gene

Monday, March 04 | 9:00AM - 12:00PM
Why Podocytes Are So Important in Kidney Disease?
Room: Sea to Sky C

Speaker 10 of 10
Fernanda V Duraes, Novartis Institute for Biomecial Research, Switzerland
Short Talk: The Role of Tissue-Resident Immune Cells in Kidney Injury and Fibrosis Development

Monday, March 04 | 12:00PM - 5:00PM
On Own for Lunch


Monday, March 04 | 12:00PM - 1:00PM
Poster Setup
Room: Sea to Sky A


Monday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Monday, March 04 | 2:30PM - 3:30PM
Workshop
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 1 of 5
* Philip J. Larsen, Bayer Pharmaceuticals, Germany


Monday, March 04 | 2:30PM - 3:30PM
Workshop
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 2 of 5
Rami Al Batran, University of Montreal, Canada
Skeletal Muscle Ketone Body Oxidation as a Novel Target for Improving Obesity-Induced Dysglycemia in Mice


Monday, March 04 | 2:30PM - 3:30PM
Workshop
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 3 of 5
Simone C. da Silva Rosa, University of Manitoba, Canada
Therapeutic Targeting of Skeletal Muscle Nix in Early-Onset Insulin Resistance


Monday, March 04 | 2:30PM - 3:30PM
Workshop
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 4 of 5
Keshav Gopal, University of Alberta, Faculty of Pharmacy and Pharmaceutical Sciences, Canada
The Antianginal Ranolazine Mitigates Obesity-Induced Non-Alcoholic Fatty Liver Disease and Increases Hepatic Pyruvate Dehydrogenase Activity


Monday, March 04 | 2:30PM - 3:30PM
Workshop
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 5 of 5
Johnna D. Wesley, Novo Nordisk Research Center Seattle, Inc., USA
Multicistronic Plasmid Immunotherapy for the Prevention of T1D


Monday, March 04 | 3:30PM - 4:30PM
Panel Discussion
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 1 of 4
* Philip J. Larsen, Bayer Pharmaceuticals, Germany


Monday, March 04 | 3:30PM - 4:30PM
Panel Discussion
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 2 of 4
Niels Porksen, Sanofi, France


Monday, March 04 | 3:30PM - 4:30PM
Panel Discussion
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 3 of 4
Craig Hammond, Eli Lilly and Company, USA


Monday, March 04 | 3:30PM - 4:30PM
Panel Discussion
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 4 of 4
Brian Finan, Novo Nordisk, USA


Monday, March 04 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Monday, March 04 | 5:00PM - 7:15PM
Harnessing the Immune System for Kidney Protection
Room: Sea to Sky C

Speaker 1 of 7
* Stuart Cook, Duke-NUS, Singapore

Monday, March 04 | 5:00PM - 7:15PM
Harnessing the Immune System for Kidney Protection
Room: Sea to Sky C

Speaker 2 of 7
* Laura Denby, University of Edinburgh, UK

Monday, March 04 | 5:00PM - 7:15PM
Harnessing the Immune System for Kidney Protection
Room: Sea to Sky C

Speaker 3 of 7
Ali Gharavi, Columbia University Medical Center, USA
Genetic and Immunological Studies of IgA Nephropathy

Monday, March 04 | 5:00PM - 7:15PM
Harnessing the Immune System for Kidney Protection
Room: Sea to Sky C

Speaker 4 of 7
Martin Pollak, Beth Israel Deaconess Medical Center, USA
Mechanisms of APOL1-Associated Kidney Disease

Monday, March 04 | 5:00PM - 7:15PM
Harnessing the Immune System for Kidney Protection
Room: Sea to Sky C

Speaker 5 of 7
David J. Salant, Boston University School of Medicine, USA
Membranous Nephropathy and PLA2R

Monday, March 04 | 5:00PM - 7:15PM
Harnessing the Immune System for Kidney Protection
Room: Sea to Sky C

Speaker 6 of 7
Mark Douglas Okusa, University of Virginia, USA
Neural Control of Inflammation in AKI

Monday, March 04 | 5:00PM - 7:15PM
Harnessing the Immune System for Kidney Protection
Room: Sea to Sky C

Speaker 7 of 7
Archana Raman, University of Pennsylvania, USA
Short Talk: APOL1 Risk Variant-Induced Kidney Injury in Mice Podocytes Is Caused by Inflammasome-Mediated Pyroptotic Cell Death

Monday, March 04 | 5:00PM - 7:00PM
Diabetes and Its Many Phenotypes
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 1 of 5
* Leif C. Groop, Lund University, Sweden


Monday, March 04 | 5:00PM - 7:00PM
Diabetes and Its Many Phenotypes
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 2 of 5
Tai E. Shyong, National University of Singapore, Singapore
Ethnically Determined Diabetes Variants (Asian Diabetes)


Monday, March 04 | 5:00PM - 7:00PM
Diabetes and Its Many Phenotypes
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 3 of 5
Keld Fosgerau, Gubra, Denmark
Short Talk: Stereological Quantification and Whole-Kidney 3D Imaging for Assessment of Key Pathological Features in a
Uni-Nephrectomised db/db Mouse Model of Diabetic Nephropathy


Monday, March 04 | 5:00PM - 7:00PM
Diabetes and Its Many Phenotypes
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 4 of 5
Simon N. Dankel, University of Bergen, Norway
Short Talk: Integrative Genomics Links Homeobox Transcription Factors to Risk of Visceral Adiposity


Monday, March 04 | 5:00PM - 7:00PM
Diabetes and Its Many Phenotypes
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 5 of 5
Joji Kusuyama, Joslin Diabetes Center, USA
Short Talk: Identification of a Novel Placenta-Derived Protein that Mediates the Beneficial Effects of Maternal Exercise on Offspring Liver


Monday, March 04 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Monday, March 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A


Tuesday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Grand Foyer


Tuesday, March 05 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Sea to Sky B/C

Speaker 1 of 2
* Tina Vilsbøll, Steno Diabetes Center Copenhagen, Denmark

Tuesday, March 05 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Sea to Sky B/C

Speaker 2 of 2
Leif C. Groop, Lund University, Sweden
A Novel Reclassification of Type 2 Diabetes – Steps Toward Precision Medicine

Tuesday, March 05 | 9:00AM - 11:15AM
Genetics and Epigenetics of Diabetes and Complications (Join
t)

Room: Sea to Sky B/C

Speaker 1 of 6
* Gregory Dressler, University of Michigan, USA

Tuesday, March 05 | 9:00AM - 11:15AM
Genetics and Epigenetics of Diabetes and Complications (Join
t)

Room: Sea to Sky B/C

Speaker 2 of 6
Jose C. Florez, Massachusetts General Hospital, USA
Genetics of Diabetic Kidney Disease

Tuesday, March 05 | 9:00AM - 11:15AM
Genetics and Epigenetics of Diabetes and Complications (Join
t)

Room: Sea to Sky B/C


Coffee Break

Tuesday, March 05 | 9:00AM - 11:15AM
Genetics and Epigenetics of Diabetes and Complications (Join
t)

Room: Sea to Sky B/C

Speaker 4 of 6
Melina Claussnitzer, Beth Israel Deaconess Medical Center, USA
Type 2 Diabetes and its Comorbidities: The Journey from GWAS to Disease Mechanism

Tuesday, March 05 | 9:00AM - 11:15AM
Genetics and Epigenetics of Diabetes and Complications (Join
t)

Room: Sea to Sky B/C

Speaker 5 of 6
Katalin Susztak, University of Pennsylvania, USA
Post-GWAS Annotation of Kidney Disease Risk Loci using eQTL and Single Cell Analysis

Tuesday, March 05 | 9:00AM - 11:15AM
Genetics and Epigenetics of Diabetes and Complications (Join
t)

Room: Sea to Sky B/C

Speaker 6 of 6
Shreeram Akilesh, University of Washington, USA
Short Talk: Integrated Genomic Analysis Enables Functional Annotation of Kidney GWAS Loci

Tuesday, March 05 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, March 05 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Tuesday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Tuesday, March 05 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Tuesday, March 05 | 5:00PM - 7:00PM
Understanding Tubule Injury and Function
Room: Sea to Sky C

Speaker 1 of 7
* Alexander Staruschenko, Medical College of Wisconsin, USA

Tuesday, March 05 | 5:00PM - 7:00PM
Understanding Tubule Injury and Function
Room: Sea to Sky C

Speaker 2 of 7
* Hyug Moo Kwon, Ulsan National Institute of Science and Technology, South Korea

Tuesday, March 05 | 5:00PM - 7:00PM
Understanding Tubule Injury and Function
Room: Sea to Sky C

Speaker 3 of 7
Masaomi Nangaku, University of Tokyo School of Medicine, Japan
The Role of Hypoxia and HIF in Tubule Injury

Tuesday, March 05 | 5:00PM - 7:00PM
Understanding Tubule Injury and Function
Room: Sea to Sky C

Speaker 4 of 7
Matthias Kretzler, University of Michigan, USA
Progression Pathways in CKD: Toward Molecular Targeting of Renal Disease

Tuesday, March 05 | 5:00PM - 7:00PM
Understanding Tubule Injury and Function
Room: Sea to Sky C

Speaker 5 of 7
Eugene Park Rhee, Massachusetts General Hospital, USA
Revisiting Kidney Function through Unbiased Profiling

Tuesday, March 05 | 5:00PM - 7:00PM
Understanding Tubule Injury and Function
Room: Sea to Sky C

Speaker 6 of 7
Verónica Miguel, Centro de Biologia Molecular Severo Ochoa, Spain
Short Talk: Cpt1a-Mediated Enhancement of Fatty Acid Oxidation in the Renal Tubule Mitigates Kidney Fibrosis

Tuesday, March 05 | 5:00PM - 7:00PM
Understanding Tubule Injury and Function
Room: Sea to Sky C

Speaker 7 of 7
Gregory Dressler, University of Michigan, USA
Short Talk: Fine Tuning TGF-ß Superfamily Signaling with Genetics or Small Molecules to Attenuate Kidney and Liver Fibrosis

Tuesday, March 05 | 5:00PM - 7:00PM
Deciphering Cellular Function of Target Tissues of Relevance
for Diabetes
This session is from Diabetes Therapies

Room: Sea to Sky B

Speaker 1 of 6
* Maike Sander, University of California, San Diego, USA


Tuesday, March 05 | 5:00PM - 7:00PM
Deciphering Cellular Function of Target Tissues of Relevance
for Diabetes
This session is from Diabetes Therapies

Room: Sea to Sky B

Speaker 2 of 6
Marcelo Nobrega, University of Chicago, USA
Experimental Dissection of the Cellular and Organismal Effects of T2D Genes


Tuesday, March 05 | 5:00PM - 7:00PM
Deciphering Cellular Function of Target Tissues of Relevance
for Diabetes
This session is from Diabetes Therapies

Room: Sea to Sky B

Speaker 3 of 6
Kenichiro Furuyama, University of Geneva, Switzerland
Conversion of Human non-ß-Cells into Insulin Producers


Tuesday, March 05 | 5:00PM - 7:00PM
Deciphering Cellular Function of Target Tissues of Relevance
for Diabetes
This session is from Diabetes Therapies

Room: Sea to Sky B

Speaker 4 of 6
James C. Lo, Weill Cornell Medicine, USA
Short Talk: Adipsin Preserves Beta Cells in Diabetic Mice and Associates with Protection from Type 2 Diabetes in Humans


Tuesday, March 05 | 5:00PM - 7:00PM
Deciphering Cellular Function of Target Tissues of Relevance
for Diabetes
This session is from Diabetes Therapies

Room: Sea to Sky B

Speaker 5 of 6
José Rivera-Feliciano, Harvard University, USA
Short Talk: A Novel Insulin-Independent Glucose Lowering Activity


Tuesday, March 05 | 5:00PM - 7:00PM
Deciphering Cellular Function of Target Tissues of Relevance
for Diabetes
This session is from Diabetes Therapies

Room: Sea to Sky B

Speaker 6 of 6
Nasa Sinnott-Armstrong, Stanford University and The Broad Institute of MIT and Harvard, USA
Short Talk: A Regulatory Variant at 3q21.1 Confers Pleiotropic Risk for High Bone Mineral Density and Hyperglycaemia


Tuesday, March 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Tuesday, March 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Wednesday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Grand Foyer


Wednesday, March 06 | 8:00AM - 12:00PM
Mechanism and Treatment of Complications of Diabetes (Joint)
Room: Sea to Sky B/C

Speaker 1 of 12
* George L. King, Joslin Diabetes Center, USA

Wednesday, March 06 | 8:00AM - 12:00PM
Mechanism and Treatment of Complications of Diabetes (Joint)
Room: Sea to Sky B/C

Speaker 2 of 12
* Julia Scialla, Duke University, USA

Wednesday, March 06 | 8:00AM - 12:00PM
Mechanism and Treatment of Complications of Diabetes (Joint)
Room: Sea to Sky B/C

Speaker 3 of 12
Susan Quaggin, Northwestern University, USA
The Role of Endothelial Cell Injury in Diabetic Kidney Disease

Wednesday, March 06 | 8:00AM - 12:00PM
Mechanism and Treatment of Complications of Diabetes (Joint)
Room: Sea to Sky B/C

Speaker 4 of 12
Farhad Danesh, University of Texas MD Anderson Cancer Center, USA
Podocyte and Mitochondrial Dysfunction in Diabetes

Wednesday, March 06 | 8:00AM - 12:00PM
Mechanism and Treatment of Complications of Diabetes (Joint)
Room: Sea to Sky B/C


Coffee Break

Wednesday, March 06 | 8:00AM - 12:00PM
Mechanism and Treatment of Complications of Diabetes (Joint)
Room: Sea to Sky B/C

Speaker 6 of 12
Hiddo Lambers Heerspink, University Medical Center Groningen, Netherlands
SGLT-2 Inhibitors and the Kidney: Extending from Diabetic to Non-Diabetic Kidneys

Wednesday, March 06 | 8:00AM - 12:00PM
Mechanism and Treatment of Complications of Diabetes (Joint)
Room: Sea to Sky B/C

Speaker 7 of 12
Donald Kohan, University of Utah Health Center, USA
Endothelin Receptors Antagonists in DKD: SONAR and Beyond

Wednesday, March 06 | 8:00AM - 12:00PM
Mechanism and Treatment of Complications of Diabetes (Joint)
Room: Sea to Sky B/C

Speaker 8 of 12
Joshua Thurman, University of Colorado, USA
Therapeutic Targeting the Complement Cascade in Kidney Disease

Wednesday, March 06 | 8:00AM - 12:00PM
Mechanism and Treatment of Complications of Diabetes (Joint)
Room: Sea to Sky B/C

Speaker 9 of 12
James Varani, University of Michigan, USA
Short Talk: CCN3-Based Peptide Inhibits Liver Injury in a Diabetic Mouse Model

Wednesday, March 06 | 8:00AM - 12:00PM
Mechanism and Treatment of Complications of Diabetes (Joint)
Room: Sea to Sky B/C

Speaker 10 of 12
Tony Wang, Kunming Biomed International, China
Short Talk: Development and Characterization of High Fat Diet-induced Non-Human Primate Models of Diabetes and Metabolic Complications of Kidney, Cardiovascular, Liver and Eye Disease

Wednesday, March 06 | 8:00AM - 12:00PM
Mechanism and Treatment of Complications of Diabetes (Joint)
Room: Sea to Sky B/C

Speaker 11 of 12
Parker C. Wilson, Washington University in St. Louis, USA
Short Talk: The Single Cell Transcriptomic Landscape of Early Human Diabetic Nephropathy

Wednesday, March 06 | 8:00AM - 12:00PM
Mechanism and Treatment of Complications of Diabetes (Joint)
Room: Sea to Sky B/C

Speaker 12 of 12
Hongbo Liu, University of Pennsylvania, USA
Short Talk: Functional Methylome Analysis of Human Diabetic Kidney Disease

Wednesday, March 06 | 12:00PM - 5:00PM
On Own for Lunch


Wednesday, March 06 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Wednesday, March 06 | 5:00PM - 7:00PM
Novel Pathways and Targets for Kidney Disease
Room: Sea to Sky C

Speaker 1 of 6
Katalin Susztak, University of Pennsylvania, USA

Wednesday, March 06 | 5:00PM - 7:00PM
Novel Pathways and Targets for Kidney Disease
Room: Sea to Sky C

Speaker 2 of 6
Samir M. Parikh, Beth Israel Deaconess Medical Center, USA
Kidney Mitochondria, NAD and Saving Kidneys

Wednesday, March 06 | 5:00PM - 7:00PM
Novel Pathways and Targets for Kidney Disease
Room: Sea to Sky C

Speaker 3 of 6
Janos Peti-Peterdi, University of Southern California, USA
New Role of Macula Densa Cells in Glomerular Remodeling

Wednesday, March 06 | 5:00PM - 7:00PM
Novel Pathways and Targets for Kidney Disease
Room: Sea to Sky C

Speaker 4 of 6
Pinelopi P. Kapitsinou, Northwestern University, USA
Short Talk: Inhibition of Endothelial PHD2 Protects Against Ischemic Kidney Injury through HIF-1 Dependent Suppression of Post-Ischemic Inflammation

Wednesday, March 06 | 5:00PM - 7:00PM
Novel Pathways and Targets for Kidney Disease
Room: Sea to Sky C

Speaker 5 of 6
Mark E. Cooper, Monash University, Australia
Short Talk: Lipoxin A4 Protects against Diabetic Nephropathy in Part by Attenuating the NLRP3 Inflammasome

Wednesday, March 06 | 5:00PM - 7:00PM
Novel Pathways and Targets for Kidney Disease
Room: Sea to Sky C

Speaker 6 of 6
Hiroshi Maekawa, University of Tokyo, Japan
Short Talk: Mitochondrial DNA Leakage Causes Inflammation via the cGAS-STING Axis in Cisplatin-Mediated Tubular Damage

Wednesday, March 06 | 5:00PM - 7:00PM
Omics Stuff and Profiling
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 1 of 6
* Samantha Laber, Broad Institute of MIT and Harvard, USA


Wednesday, March 06 | 5:00PM - 7:00PM
Omics Stuff and Profiling
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 2 of 6
Christopher B. Newgard, Duke University Medical Center, USA
Multi-Omics Strategies for Defining Cardiometabolic Disease Mechanisms and Therapeutic Targets


Wednesday, March 06 | 5:00PM - 7:00PM
Omics Stuff and Profiling
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 3 of 6
Hindrik Mulder, Lund University, Sweden
Omics Analyses of Human Islets Demonstrate Mitochondrial Dysfunction in Type 2 Diabetes


Wednesday, March 06 | 5:00PM - 7:00PM
Omics Stuff and Profiling
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 4 of 6
Martin Heni, Eberhard Karls University Tübingen, Germany
Insulin Sensitivity: More than Glycemic Control


Wednesday, March 06 | 5:00PM - 7:00PM
Omics Stuff and Profiling
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 5 of 6
Stephan Sachs, Helmholtz Zentrum München, Germany
Short Talk: Single Cell RNA Sequencing Deciphers Mechanisms of ß-Cell Failure and Regeneration after Drug Treatment


Wednesday, March 06 | 5:00PM - 7:00PM
Omics Stuff and Profiling
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 6 of 6
Ken Suzuki, University of Tokyo, Japan
Short Talk: Identification of 28 New Susceptibility loci for Type 2 Diabetes in the Japanese Population


Wednesday, March 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Thursday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Grand Foyer


Thursday, March 07 | 8:00AM - 11:00AM
Organoids and Single Cell Approaches
Room: Sea to Sky C

Speaker 1 of 9
* Gerd Walz, University Freiburg Medical Center, Germany

Thursday, March 07 | 8:00AM - 11:00AM
Organoids and Single Cell Approaches
Room: Sea to Sky C

Speaker 2 of 9
* Jurgen Heymann, National Institutes of Health, USA

Thursday, March 07 | 8:00AM - 11:00AM
Organoids and Single Cell Approaches
Room: Sea to Sky C

Speaker 3 of 9
Jonathan Himmelfarb, University of Washington, USA
A Kidney on a Chip for Drug Development

Thursday, March 07 | 8:00AM - 11:00AM
Organoids and Single Cell Approaches
Room: Sea to Sky C

Speaker 4 of 9
Benjamin D. Humphreys, Washington University, USA
Modeling Kidney Development and Repair with Organoids and scRNA-Seq

Thursday, March 07 | 8:00AM - 11:00AM
Organoids and Single Cell Approaches
Room: Sea to Sky C


Coffee Break

Thursday, March 07 | 8:00AM - 11:00AM
Organoids and Single Cell Approaches
Room: Sea to Sky C

Speaker 6 of 9
Jochen Reiser, Rush University, USA
suPAR – Immunological Risk Factor for Kidney Diseases

Thursday, March 07 | 8:00AM - 11:00AM
Organoids and Single Cell Approaches
Room: Sea to Sky C

Speaker 7 of 9
Sho Hasegawa, University of Tokyo, Japan
Short Talk: Whole-Kidney Three-Dimensional Analysis (CUBIC-kidney) Reveals Abnormal Renal Sympathetic Nerves After Ischemia-Reperfusion Injury

Thursday, March 07 | 8:00AM - 11:00AM
Organoids and Single Cell Approaches
Room: Sea to Sky C

Speaker 8 of 9
Matthew Ishahak, University of Miami, USA
Short Talk: Engineering a Physiomimetic Glomerulus-on-Chip to Model Diabetic Kidney Disease

Thursday, March 07 | 8:00AM - 11:00AM
Organoids and Single Cell Approaches
Room: Sea to Sky C

Speaker 9 of 9
Ian M. Rogers, University of Toronto, Canada
Short Talk: Manufacturing a Kidney from Stem Cells and Decellularized Kidney Matrix

Thursday, March 07 | 8:00AM - 11:00AM
Epigenomics of T2D
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 1 of 7
* Patrick Guye, InSphero AG, Switzerland


Thursday, March 07 | 8:00AM - 11:00AM
Epigenomics of T2D
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 2 of 7
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Epigenomic Regulation of Metabolism


Thursday, March 07 | 8:00AM - 11:00AM
Epigenomics of T2D
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 3 of 7
Maike Sander, University of California, San Diego, USA
Epigenetic Mechanisms of Beta Cell Functional Adaption




Thursday, March 07 | 8:00AM - 11:00AM
Epigenomics of T2D
This session is from Diabetes Therapies
Room: Sea to Sky B


Coffee Break


Thursday, March 07 | 8:00AM - 11:00AM
Epigenomics of T2D
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 5 of 7
Evan D. Rosen, Harvard University, USA
Novel Thermoregulatory Mechanisms Exposed by Single Cell Analysis of Adipose Tissue


Thursday, March 07 | 8:00AM - 11:00AM
Epigenomics of T2D
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 6 of 7
Regine Aasen Jersin, University of Bergen, Norway
Short Talk: Inhibition of the Serine Transporter SLC7A10 Limits Antioxidant Capacity and Promotes Lipid Storage in Adipocytes


Thursday, March 07 | 8:00AM - 11:00AM
Epigenomics of T2D
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 7 of 7
Debora R. Sobreira, University of Chicago, USA
Short Talk: Diabetes-Associated Variants in the FTO Locus: Dissecting the Complex Landscape of GWAS


Thursday, March 07 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, March 07 | 2:30PM - 4:30PM
Workshop
Room: Sea to Sky C

Speaker 1 of 9
* Catherine Godson, University College Dublin, Ireland

Thursday, March 07 | 2:30PM - 4:30PM
Workshop
Room: Sea to Sky C

Speaker 2 of 9
* Pinelopi P. Kapitsinou, Northwestern University, USA

Thursday, March 07 | 2:30PM - 4:30PM
Workshop
Room: Sea to Sky C

Speaker 3 of 9
Daria Ilatovskaya, Medical University of South Carolina, USA
Detecting Mitochondria ROS in Podocytes of Freshly Isolated Glomeruli during Salt-Sensitive Hypertension

Thursday, March 07 | 2:30PM - 4:30PM
Workshop
Room: Sea to Sky C

Speaker 4 of 9
Krisztian Stadler, Pennington Biomedical, USA
Chronic Kidney Disease in a New Mouse Model of Mitochondrial Overload

Thursday, March 07 | 2:30PM - 4:30PM
Workshop
Room: Sea to Sky C

Speaker 5 of 9
Tsuyoshi Inoue, University of Tokyo, Japan
Non-Canonical Cholinergic Anti-Inflammatory Pathway-Mediated Activation of Peritoneal Macrophages Induces Hes1 and Blocks Ischemia/Reperfusion Injury in the Kidney

Thursday, March 07 | 2:30PM - 4:30PM
Workshop
Room: Sea to Sky C

Speaker 6 of 9
Hiroshi Nishi, University of Tokyo, Japan
Neutrophil Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase (EIF2AK2) Promotes Vascular Adhesion and Transmigration in Non-Viral Inflammatory Disease

Thursday, March 07 | 2:30PM - 4:30PM
Workshop
Room: Sea to Sky C

Speaker 7 of 9
Jay C. Jha, Monash University, Australia
The Relative Roles of Pro-Oxidant Enzymes Nox4/Nox5 in Diabetic Kidney Disease

Thursday, March 07 | 2:30PM - 4:30PM
Workshop
Room: Sea to Sky C

Speaker 8 of 9
Francesca Oltrabella, Genentech, Inc., USA
Designing a Whole Genome CRISPR KO Pooled Screen to Identify Factors that Facilitate APOL1 Variant-Induced Cytotoxicity

Thursday, March 07 | 2:30PM - 4:30PM
Workshop
Room: Sea to Sky C

Speaker 9 of 9
Joseph M. Rutkowski, Texas A&M College of Medicine, USA
Increased Renal Lymphatic Density Improves Inflammation following AKI

Thursday, March 07 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Thursday, March 07 | 5:00PM - 7:15PM
Novel Approaches for Drug Discovery
Room: Sea to Sky C

Speaker 1 of 6
* Santiago Lamas, Centro de Biología Molecular, Spain

Thursday, March 07 | 5:00PM - 7:15PM
Novel Approaches for Drug Discovery
Room: Sea to Sky C

Speaker 2 of 6
Alan R. Shuldiner, Regeneron Pharmaceuticals, Inc, USA
Drug Discovery 2.0, the Use of Human Knock-Outs and Other Genetic Experiments of Nature

Thursday, March 07 | 5:00PM - 7:15PM
Novel Approaches for Drug Discovery
Room: Sea to Sky C

Speaker 3 of 6
Carine Boustany, Boehringer Ingelheim, USA
Novel Strategies to Treat Diabetic Kidney Disease

Thursday, March 07 | 5:00PM - 7:15PM
Novel Approaches for Drug Discovery
Room: Sea to Sky C

Speaker 4 of 6
Alex Bell, Ionis Pharmaceuticals, USA
RNA Therapeutics for Kidney Disease

Thursday, March 07 | 5:00PM - 7:15PM
Novel Approaches for Drug Discovery
Room: Sea to Sky C

Speaker 5 of 6
Stephanie Cherqui, University of California, San Diego, USA
Stem Cell and Gene Therapy for Cystinosis

Thursday, March 07 | 5:00PM - 7:15PM
Novel Approaches for Drug Discovery
Room: Sea to Sky C

Speaker 6 of 6
Thomas Soare, Goldfinch Bio, USA
Short Talk: Comparative Transcriptomic Analysis of Cultured Podocytes and Human Kidney Organoids at Single Cell-Resolution

Thursday, March 07 | 5:00PM - 6:45PM
Metabolic Surgery
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 1 of 5
* Brian Finan, Novo Nordisk, USA


Thursday, March 07 | 5:00PM - 6:45PM
Metabolic Surgery
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 2 of 5
Lee M. Kaplan, Massachusetts General Hospital, USA
Variability of Response and Prediction of Outcome


Thursday, March 07 | 5:00PM - 6:45PM
Metabolic Surgery
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 3 of 5
Filip K. Knop, Gentofte Hospital, University of Copenhagen, Denmark
A Gut Feeling About Glucagon


Thursday, March 07 | 5:00PM - 6:45PM
Metabolic Surgery
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 4 of 5
Philip J. Larsen, Bayer Pharmaceuticals, Germany
Can We Translate Bariatric Surgery into Equi-Efficacious Pharmacotherapy


Thursday, March 07 | 5:00PM - 6:45PM
Metabolic Surgery
This session is from Diabetes Therapies
Room: Sea to Sky B

Speaker 5 of 5
Berit Svendsen, University of Copenhagen, Denmark
Short Talk: GIP Receptor Blocking Improves Body Composition and Glucose Tolerance in Mice


Thursday, March 07 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Diabetes Therapies
Room: Sea to Sky B


Thursday, March 07 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Sea to Sky C


Thursday, March 07 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Thursday, March 07 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 07 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Friday, March 08 | 10:24AM - 10:24AM
Departure


*Session Chair.