Web Desc
Epigenetics and Human Disease
joint with 3D Genome: Gene Regulation and Disease
Organizer(s): Cheryl H. Arrowsmith, Anne Schaefer and Mark A. Dawson
Date: March 17 - 21, 2019
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by Cell Research, Incyte Corporation, Novartis Institutes for BioMedical Research and Pfizer Inc.
Summary of Meeting:
Epigenetics is a major mechanism in human health and disease. Data from a range of diseases (cancer, neurological and immunological disorders) have uncovered altered epigenomes arising from mutations, altered expression and/or copy number alterations of numerous epigenetic factors (histones, DNA and chromatin modifying enzymes, reader proteins, chromatin modulators and noncoding RNAs). Genome-wide analyses have illustrated the relationship between altered epigenetic states (e.g., modified DNA, histones and chromatin packaging) and disease onset and progression. Furthermore, both local and long-range nuclear chromatin architecture are increasingly recognized as major contributors to normal and pathologic epigenetic states. This conference, held jointly with a conference on “3D Genome”, will cover the most current knowledge of epigenetic events modulating nuclear function (gene expression regulation, enhancer modulation, domains and structural organization as well as cell division and differentiation), while relating this to normal and disease models. In addition, this conference will highlight the impact that preclinical and clinical epigenetic therapeutics have on multiple diseases including cancer, immunological and neurological disorders. An interdisciplinary panel of speakers including both thought leaders in the field as well as young investigators will survey the latest research results and conceptual understanding of fundamental mechanisms of epigenetic signaling, especially as they relate to regulation of gene expression programs. Presentations and workshops will highlight the latest technologies and methodologies for studying epigenetic states and 3D chromatin architecture in cells, tissues and organisms.
Scholarship Deadline: November 29 2018
Discounted Abstract Deadline: November 29 2018
Abstract Deadline: December 12 2018
Discounted Registration Deadline: January 22 2019
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Cell ResearchIncyte CorporationNovartis Institutes for BioMedical ResearchPfizer Inc.
We gratefully acknowledge additional support from these exhibitors at this conference:
EpiCypherIllumina10x Genomics
We gratefully acknowledge additional support for this conference from:
American Association for Cancer Research (AACR)American Society of Gene & Cell Therapy (ASGCT)Chroma Technology CorporationZymo Research Corporation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA236128-01
Funding for this conference was made possible (in part) by 1R13CA236128-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 17 | 4:00PM - 8:00PM
Arrival and Registration
Room: Van Horne Foyer


Sunday, March 17 | 6:00PM - 8:00PM
Welcome Mixer
Room: Van Horne Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 18 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Monday, March 18 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 1 of 5
* Cheryl Arrowsmith, University of Toronto, Canada

Monday, March 18 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 2 of 5
* Bing Ren, Ludwig Institute for Cancer Research, USA

Monday, March 18 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 3 of 5
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Transcriptional Regulation, Epigenetics and Disease

Monday, March 18 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 4 of 5
Wendy A. Bickmore, University of Edinburgh, UK
Spatial Organization of the Human Genome in Disease and Senescence

Monday, March 18 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B


Coffee Break

Monday, March 18 | 9:50AM - 12:15PM
3D Epigenome/Epigenetics and Disease (Joint)
Room: Van Horne A/B

Speaker 1 of 7
* Anne Schaefer, Mount Sinai School of Medicine, USA

Monday, March 18 | 9:50AM - 12:15PM
3D Epigenome/Epigenetics and Disease (Joint)
Room: Van Horne A/B

Speaker 2 of 7
Matthias Merkenschlager, Imperial College London, UK
Quantitative Approaches to Cohesin-Dependent Regulation of Transcription

Monday, March 18 | 9:50AM - 12:15PM
3D Epigenome/Epigenetics and Disease (Joint)
Room: Van Horne A/B

Speaker 3 of 7
Mathieu Lupien, University Health Network, Canada
Epigenetics Variants in Cancer

Monday, March 18 | 9:50AM - 12:15PM
3D Epigenome/Epigenetics and Disease (Joint)
Room: Van Horne A/B

Speaker 4 of 7
Joanna Wysocka, Stanford University, USA
Epigenetic Regulation of Craniofacial Development

Monday, March 18 | 9:50AM - 12:15PM
3D Epigenome/Epigenetics and Disease (Joint)
Room: Van Horne A/B

Speaker 5 of 7
John Alan Wildenthal, NCI, National Institutes of Health, USA
Short Talk: Elucidating Enhancers Governing Human Pancreas Cell Identity and Function

Monday, March 18 | 9:50AM - 12:15PM
3D Epigenome/Epigenetics and Disease (Joint)
Room: Van Horne A/B

Speaker 6 of 7
Yin Shen, University of California, San Francisco, USA
Short Talk: Charting Cell-Specific 3D Epigenomes during Corticogenesis to Understand
Human Brain Development and Complex Disorders


Monday, March 18 | 9:50AM - 12:15PM
3D Epigenome/Epigenetics and Disease (Joint)
Room: Van Horne A/B

Speaker 7 of 7
Evgeny Kvon, Lawrence Berkeley National Laboratory, USA
Short Talk: Saturation Mutagenesis Reveals Functional Impact of Enhancer Mutations in vivo

Monday, March 18 | 12:15PM - 5:00PM
On Own for Lunch


Monday, March 18 | 12:15PM - 1:00PM
Poster Setup
Room: Mezzanine 2


Monday, March 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: Epigenetic Memory and Inheritance in Health and
Disease
Room: Van Horne A/B

Speaker 1 of 8
* Mathieu Lupien, University Health Network, Canada

Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: Epigenetic Memory and Inheritance in Health and
Disease
Room: Van Horne A/B

Speaker 2 of 8
Berkley Eric Gryder, NCI, National Institutes of Health, USA
Chemical Disruption of Core Regulatory Architecture in Rhabdomyosarcoma

Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: Epigenetic Memory and Inheritance in Health and
Disease
Room: Van Horne A/B

Speaker 3 of 8
Navneet Matharu, University of California, San Francisco, USA
CRISPRa-Mediated Activation of Promoter or Enhancer Corrects Haploinsufficiency

Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: Epigenetic Memory and Inheritance in Health and
Disease
Room: Van Horne A/B

Speaker 4 of 8
Benjamin A. Nacev, Memorial Sloan Kettering Cancer Center, USA
Expanding the Landscape of 'Oncohistone' Mutations in Human Cancers

Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: Epigenetic Memory and Inheritance in Health and
Disease
Room: Van Horne A/B

Speaker 5 of 8
Kirsten C. Sadler, New York University Abu Dhabi, United Arab Emirates
Epigenetic Compensation Promotes Liver Regeneration

Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: Epigenetic Memory and Inheritance in Health and
Disease
Room: Van Horne A/B

Speaker 6 of 8
Shu-Ping Wang, Academia Sinica, Taiwan
Critical Roles of the MLL4 Complex in Establishing an Active Enhancer Landscape in Normal and Pathological Conditions

Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: Epigenetic Memory and Inheritance in Health and
Disease
Room: Van Horne A/B

Speaker 7 of 8
Yael David, Memorial Sloan Kettering Cancer Center, USA
Reversible Histone Glycation Drives Cancer- Associated Changes in Chromatin Architecture

Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: Epigenetic Memory and Inheritance in Health and
Disease
Room: Van Horne A/B

Speaker 8 of 8
Joel B. Berletch, University of Washington, USA
Differential Epigenetic Regulation of Maternal and Paternal Alleles by the Histone Demethylase KDM6A

Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: 4DN Nucleome Consortium Resources
This session is from 3D Genome
Room: Van Horne C
In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them.
Speaker 1 of 8
Judy Mietz, NCI, National Institutes of Health, USA
4DN Current Scope and Outlook


Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: 4DN Nucleome Consortium Resources
This session is from 3D Genome
Room: Van Horne C
In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them.
Speaker 2 of 8
Olivier Blondel, NIDDK, National Institutes of Health, USA
4DN Current Scope and Outlook


Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: 4DN Nucleome Consortium Resources
This session is from 3D Genome
Room: Van Horne C
In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them.
Speaker 3 of 8
Burak H. Alver, Harvard Medical School, USA
4DN Data Portal


Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: 4DN Nucleome Consortium Resources
This session is from 3D Genome
Room: Van Horne C
In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them.
Speaker 4 of 8
Feng Yue, Pennsylvania State University, USA
Introduction to 4DN Joint Analysis


Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: 4DN Nucleome Consortium Resources
This session is from 3D Genome
Room: Van Horne C
In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them.
Speaker 5 of 8
Nick Gilbert, University of Edinburgh, UK
Chromatin-Associated RNA Recycling by XRN2 Regulates Transcription and Chromosome Structure


Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: 4DN Nucleome Consortium Resources
This session is from 3D Genome
Room: Van Horne C
In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them.
Speaker 6 of 8
Rieke Kempfer, Max Delbrück Center, Germany
Higher-Order Chromatin Contacts and Regulatory Networks in the ESC Genome.


Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: 4DN Nucleome Consortium Resources
This session is from 3D Genome
Room: Van Horne C
In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them.
Speaker 7 of 8
* Sheng Zhong, University of California, San Diego, USA
RNA as Proximity Labeling Media for Connecting Microscopic and Omics Data of Nuclear Organization


Monday, March 18 | 2:30PM - 4:30PM
Workshop 1: 4DN Nucleome Consortium Resources
This session is from 3D Genome
Room: Van Horne C
In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them.
Speaker 8 of 8
Zhen Chen, City of Hope, USA
Endothelial Functional Regulation by Enhancer-Associated Long Non-Coding RNAs


Monday, March 18 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Monday, March 18 | 5:00PM - 7:00PM
Epigenetic Dysregulation in Neurobiology
Room: Van Horne A/B

Speaker 1 of 6
* Wendy A. Bickmore, University of Edinburgh, UK

Monday, March 18 | 5:00PM - 7:00PM
Epigenetic Dysregulation in Neurobiology
Room: Van Horne A/B

Speaker 2 of 6
Anne Schaefer, Mount Sinai School of Medicine, USA
Epigenetic Regulation of Neurodevelopment and Neurodegeneration

Monday, March 18 | 5:00PM - 7:00PM
Epigenetic Dysregulation in Neurobiology
Room: Van Horne A/B

Speaker 3 of 6
Danny F. Reinberg, HHMI/New York University, USA
The Epigenetic Status of Some Histone Post-Translational Modifications

Monday, March 18 | 5:00PM - 7:00PM
Epigenetic Dysregulation in Neurobiology
Room: Van Horne A/B

Speaker 4 of 6
Shelley L. Berger, University of Pennsylvania, USA
Epigenetic Pathways as Targets in Human Cancer


Monday, March 18 | 5:00PM - 7:00PM
Epigenetic Dysregulation in Neurobiology
Room: Van Horne A/B

Speaker 5 of 6
Gonçalo Castelo-Branco, Karolinska Institutet, Sweden
Short Talk: Single-Cell Transcriptomics and Epigenomics Reveal Disease-Specific States of Oligodendroglia in Multiple Sclerosis

Monday, March 18 | 5:00PM - 7:00PM
Epigenetic Dysregulation in Neurobiology
Room: Van Horne A/B

Speaker 6 of 6
Lorna Farrelly, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Glutamine 5 Serotonylation on Histone H3 Is a Permissive Modification that Functions Combinatorially with
H3K4me3 to Potentiate Gene Expression


Monday, March 18 | 5:00PM - 7:30PM
Single Cell Analysis of Genome Architecture
This session is from 3D Genome
Room: Van Horne C

Speaker 1 of 8
* Xiaowei Zhuang, Harvard University, USA


Monday, March 18 | 5:00PM - 7:30PM
Single Cell Analysis of Genome Architecture
This session is from 3D Genome
Room: Van Horne C

Speaker 2 of 8
Alistair Boettiger, Stanford University, USA
Visualizing 3D Genome Architecture and Gene Expression during Embryogenesis


Monday, March 18 | 5:00PM - 7:30PM
Single Cell Analysis of Genome Architecture
This session is from 3D Genome
Room: Van Horne C

Speaker 3 of 8
Peter Fraser, Florida State University, USA
Cell Cycle Dynamics of Chromosomal Organization at Single-Cell Resolution


Monday, March 18 | 5:00PM - 7:30PM
Single Cell Analysis of Genome Architecture
This session is from 3D Genome
Room: Van Horne C

Speaker 4 of 8
Ibrahim Cissé, Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Live Mammalian Cells


Monday, March 18 | 5:00PM - 7:30PM
Single Cell Analysis of Genome Architecture
This session is from 3D Genome
Room: Van Horne C

Speaker 5 of 8
Blanca Pijuan-Sala, University of Cambridge, UK
Short Talk: Using Single-Cell Chromatin Accessibility Profiling to Study the Regulatory
Mechanisms Underlying Early Mouse Organogenesis


Monday, March 18 | 5:00PM - 7:30PM
Single Cell Analysis of Genome Architecture
This session is from 3D Genome
Room: Van Horne C

Speaker 6 of 8
Akihito Harada, Kyushu University, Japan
Short Talk: High-Throughput Single Cell Epigenomic Profiling using Chromatin Integration
Labeling-Sequence


Monday, March 18 | 5:00PM - 7:30PM
Single Cell Analysis of Genome Architecture
This session is from 3D Genome
Room: Van Horne C

Speaker 7 of 8
Seungsoo Kim, University of Washington, USA
Short Talk: A Combination of Transcription Factors Mediates Inducible Interchromosomal Contacts


Monday, March 18 | 5:00PM - 7:30PM
Single Cell Analysis of Genome Architecture
This session is from 3D Genome
Room: Van Horne C

Speaker 8 of 8
Jesse M. Engreitz, Harvard University and Broad Institute, USA
Short Talk: Activity-by-Contact Model of Enhancer Specificity from Thousands of CRISPR Perturbations


Monday, March 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Monday, March 18 | 7:30PM - 10:00PM
Poster Session 1
Room: Mezzanine 2


Tuesday, March 19 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Tuesday, March 19 | 8:00AM - 11:15AM
Understanding and Targeting Epigenetic Dysregulation
Room: Van Horne A/B

Speaker 1 of 9
* Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA

Tuesday, March 19 | 8:00AM - 11:15AM
Understanding and Targeting Epigenetic Dysregulation
Room: Van Horne A/B

Speaker 2 of 9
Mark A. Dawson, Peter MacCallum Cancer Centre, Australia
Mechanisms of Epigenetic Therapeutics in Leukemia

Tuesday, March 19 | 8:00AM - 11:15AM
Understanding and Targeting Epigenetic Dysregulation
Room: Van Horne A/B

Speaker 3 of 9
Johannes Zuber, Research Institute of Molecular Pathology, Austria
Decoding Transcriptional Dependencies in Leukemia

Tuesday, March 19 | 8:00AM - 11:15AM
Understanding and Targeting Epigenetic Dysregulation
Room: Van Horne A/B


Coffee Break

Tuesday, March 19 | 8:00AM - 11:15AM
Understanding and Targeting Epigenetic Dysregulation
Room: Van Horne A/B

Speaker 5 of 9
Cheryl Arrowsmith, University of Toronto, Canada
Probing the Epigenome for Therapeutic Opportunities

Tuesday, March 19 | 8:00AM - 11:15AM
Understanding and Targeting Epigenetic Dysregulation
Room: Van Horne A/B

Speaker 6 of 9
Marie Classon, USA
Epigenetic Mechanisms of Drug Resistance

Tuesday, March 19 | 8:00AM - 11:15AM
Understanding and Targeting Epigenetic Dysregulation
Room: Van Horne A/B

Speaker 7 of 9
Sarah Attwell, Zenith Epigenetics Corp., Canada
Short Talk: The BET Inhibitor ZEN-3694 Blocks Multiple Tumor Immune Suppressive Factors and Has the Potential to Increase the Efficacy of Anti-PD1 Treatment

Tuesday, March 19 | 8:00AM - 11:15AM
Understanding and Targeting Epigenetic Dysregulation
Room: Van Horne A/B

Speaker 8 of 9
M. Ryan Corces, Stanford University, USA
Short Talk: The Chromatin Accessibility Landscape of Primary Human Cancers

Tuesday, March 19 | 8:00AM - 11:15AM
Understanding and Targeting Epigenetic Dysregulation
Room: Van Horne A/B

Speaker 9 of 9
Céline Vallot, Institut Curie, France
Short Talk: Single-Cell Chromatin Profiling Reveals Heterogeneity of Chromatin States in Breast Cancer

Tuesday, March 19 | 8:00AM - 11:00AM
Analysis of 3D Genome with Advanced Microscopy
This session is from 3D Genome
Room: Van Horne C

Speaker 1 of 8
* Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany


Tuesday, March 19 | 8:00AM - 11:00AM
Analysis of 3D Genome with Advanced Microscopy
This session is from 3D Genome
Room: Van Horne C

Speaker 2 of 8
Cornelis Murre, University of California, San Diego, USA
The Role of Non-Coding Transcription in Compartmentalization


Tuesday, March 19 | 8:00AM - 11:00AM
Analysis of 3D Genome with Advanced Microscopy
This session is from 3D Genome
Room: Van Horne C

Speaker 3 of 8
Andrew S. Belmont, University of Illinois at Urbana-Champaign, USA
Nuclear Speckle Association Modulates Transcription Revealed through Live-Cell Imaging


Tuesday, March 19 | 8:00AM - 11:00AM
Analysis of 3D Genome with Advanced Microscopy
This session is from 3D Genome
Room: Van Horne C


Coffee Break


Tuesday, March 19 | 8:00AM - 11:00AM
Analysis of 3D Genome with Advanced Microscopy
This session is from 3D Genome
Room: Van Horne C

Speaker 5 of 8
Hanhui Ma, Shanghaitech University, China
Short Talk: “CRISPRadius” Reveals that DNA and Histone Modifications Cooperatively Regulate Heterochromatin Condensates


Tuesday, March 19 | 8:00AM - 11:00AM
Analysis of 3D Genome with Advanced Microscopy
This session is from 3D Genome
Room: Van Horne C

Speaker 6 of 8
Clodagh C. O'Shea, The Salk Institute for Biological Studies, USA
Cracking the Nucleus: Visualizing the Higher Coding Structures of DNA


Tuesday, March 19 | 8:00AM - 11:00AM
Analysis of 3D Genome with Advanced Microscopy
This session is from 3D Genome
Room: Van Horne C

Speaker 7 of 8
Magda Bienko, Karolinska Institutet, Sweden
Short Talk: Radial Organization of the Genome Revealed by GPSeq


Tuesday, March 19 | 8:00AM - 11:00AM
Analysis of 3D Genome with Advanced Microscopy
This session is from 3D Genome
Room: Van Horne C

Speaker 8 of 8
Erez Lieberman-Aiden, Baylor College of Medicine, USA
Tracking Genome Architecture in Space, in Time and in Single Cells


Tuesday, March 19 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, March 19 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Tuesday, March 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: Novel Modifications of Chromatin & RNA: Detectio
n, Quantification and Functional Significance
Room: Van Horne A/B

Speaker 1 of 6
* François Fuks, Université Libre de Bruxelles, Belgium
Transcriptome-Wide Distribution and Function of RNA Modifications

Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: Novel Modifications of Chromatin & RNA: Detectio
n, Quantification and Functional Significance
Room: Van Horne A/B

Speaker 2 of 6
Adriana Z. Corvalan, University of California, Los Angeles, USA
Understanding the Role of H4K20me3 and Suv4-20h2 in Cellular Quiescence

Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: Novel Modifications of Chromatin & RNA: Detectio
n, Quantification and Functional Significance
Room: Van Horne A/B

Speaker 3 of 6
Harrison W. Gabel, Washington University School of Medicine, USA
Non-CG DNA Methylation in Neurodevelopmental Disorders

Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: Novel Modifications of Chromatin & RNA: Detectio
n, Quantification and Functional Significance
Room: Van Horne A/B

Speaker 4 of 6
Simão Teixeira Rocha, Instituto de Medicina Molecular Joao Lobo Antunes, Portugal
Exploring the Role of Polycomb Recruitment in Xist-Mediated Silencing of the X Chromosome in ES Cells

Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: Novel Modifications of Chromatin & RNA: Detectio
n, Quantification and Functional Significance
Room: Van Horne A/B

Speaker 5 of 6
Rohan Nishant Shah, University of Chicago, USA
Quantitative Studies of Histone Modifications


Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: Novel Modifications of Chromatin & RNA: Detectio
n, Quantification and Functional Significance
Room: Van Horne A/B

Speaker 6 of 6
Zibo Zhao, Northwestern University, USA
Regulation of MLL/COMPASS Stability Through Its Proteolytic Cleavage by Taspase1 as a Possible Approach for Clinical Therapy of Leukemia

Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: ENCODE Consortium Resources
This session is from 3D Genome
Room: Van Horne C
The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium.
Speaker 1 of 8
* Feng Yue, Pennsylvania State University, USA


Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: ENCODE Consortium Resources
This session is from 3D Genome
Room: Van Horne C
The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium.
Speaker 2 of 8
Michael J. Pazin, NHGRI, National Institutes of Health, USA
Overview of ENCODE Project


Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: ENCODE Consortium Resources
This session is from 3D Genome
Room: Van Horne C
The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium.
Speaker 3 of 8
Zhiping Weng, University of Massachusetts, USA
ENCODE DAC


Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: ENCODE Consortium Resources
This session is from 3D Genome
Room: Van Horne C
The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium.
Speaker 4 of 8
Jason Hilton, Stanford University, USA
ENCODE DAC


Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: ENCODE Consortium Resources
This session is from 3D Genome
Room: Van Horne C
The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium.
Speaker 5 of 8
Jian Ma, Carnegie Mellon University, USA
Comparing 3D Genome Organization in Multiple Species using Phylo-HMRF


Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: ENCODE Consortium Resources
This session is from 3D Genome
Room: Van Horne C
The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium.
Speaker 6 of 8
Yanxiao Zhang, Ludwig Institute for Cancer Research, USA
Primate-Specific Retrotransposon HERV-H Demarcates Chromatin Domains in Lineage Specification and Evolution


Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: ENCODE Consortium Resources
This session is from 3D Genome
Room: Van Horne C
The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium.
Speaker 7 of 8
Joe Spidle, Arima Genomics, Inc., USA
Rapid and Sensitive Discovery of Genomic Interactions using Arima-HiC


Tuesday, March 19 | 2:30PM - 4:30PM
Workshop 2: ENCODE Consortium Resources
This session is from 3D Genome
Room: Van Horne C
The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium.
Speaker 8 of 8
Michael Christopher Keogh, EpiCypher Inc, USA
Fixing ChIP with Next-Generation Spike-In Controls


Tuesday, March 19 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, March 19 | 5:00PM - 7:00PM
Infectious Diseases and Autoimmunity
Room: Van Horne A/B

Speaker 1 of 6
* Rab K. Prinjha, GlaxoSmithKline, UK

Tuesday, March 19 | 5:00PM - 7:00PM
Infectious Diseases and Autoimmunity
Room: Van Horne A/B

Speaker 2 of 6
Eric A. Miska, University of Cambridge, UK
RNA Modifications and Novel Antiviral Response

Tuesday, March 19 | 5:00PM - 7:00PM
Infectious Diseases and Autoimmunity
Room: Van Horne A/B

Speaker 3 of 6
Alexander Tarakhovsky, Rockefeller University, USA
I-BET, Inflammation, Histone Mimicry in Pathogens, Antiviral Response

Tuesday, March 19 | 5:00PM - 7:00PM
Infectious Diseases and Autoimmunity
Room: Van Horne A/B

Speaker 4 of 6
Madle Sirel, Karolinska Institutet, Sweden
Short Talk: Epigenetics of Parasites Causing Placental Malaria

Tuesday, March 19 | 5:00PM - 7:00PM
Infectious Diseases and Autoimmunity
Room: Van Horne A/B

Speaker 5 of 6
Colby Zaph, Monash University, Australia
Regulatory T Cell Stability Is Controlled by the Lysine Methyltransferase G9a Independently of DNA Methylation

Tuesday, March 19 | 5:00PM - 7:00PM
Infectious Diseases and Autoimmunity
Room: Van Horne A/B

Speaker 6 of 6
Timothy M. Johanson, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Pax5 Organizes the B Cell Genome in Three-Dimensions Independent of Transcription

Tuesday, March 19 | 5:00PM - 7:15PM
Chromatin and Epigenetics
This session is from 3D Genome
Room: Van Horne C

Speaker 1 of 7
* X. Shirley Liu, Dana-Farber Cancer Institute, USA


Tuesday, March 19 | 5:00PM - 7:15PM
Chromatin and Epigenetics
This session is from 3D Genome
Room: Van Horne C

Speaker 2 of 7
Bas van Steensel, Netherlands Cancer Institute, Netherlands
Rewiring of LADs by Transcription


Tuesday, March 19 | 5:00PM - 7:15PM
Chromatin and Epigenetics
This session is from 3D Genome
Room: Van Horne C

Speaker 3 of 7
Mitchell Guttman, California Institute of Technology, USA
3D Genome Organization and X Chromosome Inactivation


Tuesday, March 19 | 5:00PM - 7:15PM
Chromatin and Epigenetics
This session is from 3D Genome
Room: Van Horne C

Speaker 4 of 7
Joseph R. Ecker, The Salk Institute for Biological Studies, USA
Single Cell Analysis of DNA Methylation


Tuesday, March 19 | 5:00PM - 7:15PM
Chromatin and Epigenetics
This session is from 3D Genome
Room: Van Horne C

Speaker 5 of 7
Chen-Yu Wang, Massachusetts General Hospital, USA
Short Talk: SMCHD1 Regulates the Folding of the Inactive X Chromosome and Select Autosomal loci


Tuesday, March 19 | 5:00PM - 7:15PM
Chromatin and Epigenetics
This session is from 3D Genome
Room: Van Horne C

Speaker 6 of 7
Candice Byers, Tufts University, USA
Short Talk: Cellular Systems Genetics Implicates KRAB Zinc Finger Proteins in Mediating
Variation in Chromatin State in Pluripotent Stem Cells


Tuesday, March 19 | 5:00PM - 7:15PM
Chromatin and Epigenetics
This session is from 3D Genome
Room: Van Horne C

Speaker 7 of 7
Marc Bühler, Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: A Transcription Factor Implicated in Autism Locally Constrains Chromatin Looping


Tuesday, March 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Tuesday, March 19 | 7:30PM - 10:00PM
Poster Session 2
Room: Mezzanine 2


Wednesday, March 20 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Wednesday, March 20 | 8:00AM - 11:15AM
Chromatin Signaling and Epigenetic Mechanisms
Room: Van Horne A/B

Speaker 1 of 9
* Anne Brunet, Stanford University, USA

Wednesday, March 20 | 8:00AM - 11:15AM
Chromatin Signaling and Epigenetic Mechanisms
Room: Van Horne A/B

Speaker 2 of 9
Christopher Vakoc, Cold Spring Harbor Laboratory, USA
Transcriptional Addiction in Cancer

Wednesday, March 20 | 8:00AM - 11:15AM
Chromatin Signaling and Epigenetic Mechanisms
Room: Van Horne A/B

Speaker 3 of 9
Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School, USA
Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease

Wednesday, March 20 | 8:00AM - 11:15AM
Chromatin Signaling and Epigenetic Mechanisms
Room: Van Horne A/B


Coffee Break

Wednesday, March 20 | 8:00AM - 11:15AM
Chromatin Signaling and Epigenetic Mechanisms
Room: Van Horne A/B

Speaker 5 of 9
Paola Scaffidi, Francis Crick Institute, UK
Epigenetics and Functional Intratumor Heterogeneity

Wednesday, March 20 | 8:00AM - 11:15AM
Chromatin Signaling and Epigenetic Mechanisms
Room: Van Horne A/B

Speaker 6 of 9
Xiaobing Shi, Van Andel Institute, USA
Identification of the ZZ Domain as a Novel Histone Reader

Wednesday, March 20 | 8:00AM - 11:15AM
Chromatin Signaling and Epigenetic Mechanisms
Room: Van Horne A/B

Speaker 7 of 9
Kelly Barnett, Vanderbilt University, USA
Short Talk: ATAC-Me Captures Spatiotemporal Dynamics of DNA Methylation Across the Chromatin Accessible Genome during
a Monocyte-to-Macrophage Transition


Wednesday, March 20 | 8:00AM - 11:15AM
Chromatin Signaling and Epigenetic Mechanisms
Room: Van Horne A/B

Speaker 8 of 9
Susan J. Clark, Garvan Institute of Medical Research, Australia
Short Talk: DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Mono-Methylation
Patterns


Wednesday, March 20 | 8:00AM - 11:15AM
Chromatin Signaling and Epigenetic Mechanisms
Room: Van Horne A/B

Speaker 9 of 9
Hatice S. Kaya-Okur, Fred Hutchinson Cancer Research Center, USA
Short Talk: CUT&Tag for Efficient Epigenomic Profiling of Small Samples and Single Cells

Wednesday, March 20 | 8:00AM - 11:00AM
3D Genome and Gene Regulation
This session is from 3D Genome
Room: Van Horne C

Speaker 1 of 7
* Mathieu Lupien, University Health Network, Canada


Wednesday, March 20 | 8:00AM - 11:00AM
3D Genome and Gene Regulation
This session is from 3D Genome
Room: Van Horne C

Speaker 2 of 7
Bing Ren, Ludwig Institute for Cancer Research, USA
Systematic Identification and Characterization of Promoter-Enhancer Interactions in the Human Genome


Wednesday, March 20 | 8:00AM - 11:00AM
3D Genome and Gene Regulation
This session is from 3D Genome
Room: Van Horne C

Speaker 3 of 7
Gerd A. Blobel, Children's Hospital of Philadelphia, USA
Re-Configuration of Chromatin Structure During the Mitosis-G1 Phase Transition


Wednesday, March 20 | 8:00AM - 11:00AM
3D Genome and Gene Regulation
This session is from 3D Genome
Room: Van Horne C


Coffee Break


Wednesday, March 20 | 8:00AM - 11:00AM
3D Genome and Gene Regulation
This session is from 3D Genome
Room: Van Horne C

Speaker 5 of 7
Jennifer E. Phillips-Cremins, University of Pennsylvania, USA
LADL: Light-­Activated Dynamic Looping for Endogenous Gene Expression Control


Wednesday, March 20 | 8:00AM - 11:00AM
3D Genome and Gene Regulation
This session is from 3D Genome
Room: Van Horne C

Speaker 6 of 7
Stavros Lomvardas, Columbia University, USA
3D Chromatin Organization of the Olfactory Receptor Locus


Wednesday, March 20 | 8:00AM - 11:00AM
3D Genome and Gene Regulation
This session is from 3D Genome
Room: Van Horne C

Speaker 7 of 7
X. Shirley Liu, Dana-Farber Cancer Institute, USA
Epigenomic Analysis of Cancer Cells


Wednesday, March 20 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, March 20 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Wednesday, March 20 | 11:30AM - 12:30PM
Roundtable Discussion: Women in Science (Joint)
Room: Conservatory


Wednesday, March 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Wednesday, March 20 | 2:30PM - 4:30PM
Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin
g Enzymes
Room: Van Horne A/B

Speaker 1 of 7
* Nada Jabado, McGill University Health Centre, Canada
Therapeutic Vulnerability of the K27M Oncohistone: Finding Achilles' Heel in Gliomas?

Wednesday, March 20 | 2:30PM - 4:30PM
Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin
g Enzymes
Room: Van Horne A/B

Speaker 2 of 7
Danielle Bozek, University of Calgary, Canada
DOT1L Epigenetically Regulates Glioblastoma Cancer Stem Cell Properties

Wednesday, March 20 | 2:30PM - 4:30PM
Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin
g Enzymes
Room: Van Horne A/B

Speaker 3 of 7
Patrizia Casaccia, Advanced Science Research Center, USA
DNA Hydroxymethylation Impacts Age-Dependent Myelin Regeneration in the Central Nervous System

Wednesday, March 20 | 2:30PM - 4:30PM
Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin
g Enzymes
Room: Van Horne A/B

Speaker 4 of 7
Bilal N. Sheikh, Max Planck Institute for Immunobiology and Epigenetics, Germany
Neural Metabolic Defects Lead to Inflammation and Brain Haemorrhage

Wednesday, March 20 | 2:30PM - 4:30PM
Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin
g Enzymes
Room: Van Horne A/B

Speaker 5 of 7
Gabriel Oh, Centre for Addiction and Mental Health, Canada
Circadian DNA Modification Hallmarks of Aging and Disease

Wednesday, March 20 | 2:30PM - 4:30PM
Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin
g Enzymes
Room: Van Horne A/B

Speaker 6 of 7
Andreas R. Pfenning, Carnegie Mellon University, USA
Epigenomic Profiling of Major Human Brain Cell Types Reveals Sex Specific Differences in Hippocampal Oligodendrocyte Gene Regulation in Alzheimer's Disease

Wednesday, March 20 | 2:30PM - 4:30PM
Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin
g Enzymes
Room: Van Horne A/B

Speaker 7 of 7
Emmanuelle Vire, University College London, UK
Altered DNA Methylation Signatures to Better Detect, Classify, and Understand Human Prion Diseases

Wednesday, March 20 | 2:30PM - 4:30PM
Workshop 3: International Human Epigenome Consortium
This session is from 3D Genome
Room: Van Horne C
The IHEC consortium is an international consortium of investigators dedicated to the study of epigenomes in normal and disease cells. It has made major contributions to the development of new technologies and generation of valuable datasets to the field of epigenomics. This workshop will feature short presentations and tutorials aimed at facilitating the dissemination of resources and tools from the IHEC consortium.
Speaker 1 of 5
Martin Hirst, BC Cancer Agency, Canada
Introduction to International Human Epigenome Consortium


Wednesday, March 20 | 2:30PM - 4:30PM
Workshop 3: International Human Epigenome Consortium
This session is from 3D Genome
Room: Van Horne C
The IHEC consortium is an international consortium of investigators dedicated to the study of epigenomes in normal and disease cells. It has made major contributions to the development of new technologies and generation of valuable datasets to the field of epigenomics. This workshop will feature short presentations and tutorials aimed at facilitating the dissemination of resources and tools from the IHEC consortium.
Speaker 2 of 5
David Bujold, McGill University, Canada
Epigenomic Data Discovery with the IHEC Data Portal


Wednesday, March 20 | 2:30PM - 4:30PM
Workshop 3: International Human Epigenome Consortium
This session is from 3D Genome
Room: Van Horne C
The IHEC consortium is an international consortium of investigators dedicated to the study of epigenomes in normal and disease cells. It has made major contributions to the development of new technologies and generation of valuable datasets to the field of epigenomics. This workshop will feature short presentations and tutorials aimed at facilitating the dissemination of resources and tools from the IHEC consortium.
Speaker 3 of 5
Charles Dupras, McGill University, Canada
Potential (Mis)use of Epigenetic Age Estimators by Private Companies and Public Agencies: Are Legal Safeguards Required?


Wednesday, March 20 | 2:30PM - 4:30PM
Workshop 3: International Human Epigenome Consortium
This session is from 3D Genome
Room: Van Horne C
The IHEC consortium is an international consortium of investigators dedicated to the study of epigenomes in normal and disease cells. It has made major contributions to the development of new technologies and generation of valuable datasets to the field of epigenomics. This workshop will feature short presentations and tutorials aimed at facilitating the dissemination of resources and tools from the IHEC consortium.
Speaker 4 of 5
* Danny C.Y. Leung, Hong Kong University of Science and Technology, Hong Kong
Epigenomic Analyses of Retrotransposon-Derived cis-Regulatory Elements in Distinct Human Cell-Types


Wednesday, March 20 | 2:30PM - 4:30PM
Workshop 3: International Human Epigenome Consortium
This session is from 3D Genome
Room: Van Horne C
The IHEC consortium is an international consortium of investigators dedicated to the study of epigenomes in normal and disease cells. It has made major contributions to the development of new technologies and generation of valuable datasets to the field of epigenomics. This workshop will feature short presentations and tutorials aimed at facilitating the dissemination of resources and tools from the IHEC consortium.
Speaker 5 of 5
Martin Hirst, BC Cancer Agency, Canada
Polycomb Contraction during Human Granulopoietic Lineage Restriction


Wednesday, March 20 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, March 20 | 5:00PM - 7:00PM
Metabolic Diseases and Aging
Room: Van Horne A/B

Speaker 1 of 6
* Shelley L. Berger, University of Pennsylvania, USA

Wednesday, March 20 | 5:00PM - 7:00PM
Metabolic Diseases and Aging
Room: Van Horne A/B

Speaker 2 of 6
Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA
Role of Mutations in Epigenetic Regulators in Pathogenesis of AML

Wednesday, March 20 | 5:00PM - 7:00PM
Metabolic Diseases and Aging
Room: Van Horne A/B

Speaker 3 of 6
Stefan Horvath, University of California, Los Angeles, USA
Epigenetic Aging Clock versus Gene Regulation

Wednesday, March 20 | 5:00PM - 7:00PM
Metabolic Diseases and Aging
Room: Van Horne A/B

Speaker 4 of 6
Anne Brunet, Stanford University, USA
Epigenetic Regulation of Aging

Wednesday, March 20 | 5:00PM - 7:00PM
Metabolic Diseases and Aging
Room: Van Horne A/B

Speaker 5 of 6
Louis Coussement, University Ghent, Belgium
Short Talk: The Aging Genome: CpG Depletion throughout Human Evolution

Wednesday, March 20 | 5:00PM - 7:00PM
Metabolic Diseases and Aging
Room: Van Horne A/B

Speaker 6 of 6
Anita Öst, Linköping University, Sweden
Short Talk: Diet-Sensitive Fragmentation of Sperm tRNA

Wednesday, March 20 | 5:00PM - 7:15PM
Genome Architecture and Development
This session is from 3D Genome
Room: Van Horne C

Speaker 1 of 7
* Jennifer E. Phillips-Cremins, University of Pennsylvania, USA


Wednesday, March 20 | 5:00PM - 7:15PM
Genome Architecture and Development
This session is from 3D Genome
Room: Van Horne C

Speaker 2 of 7
Wei Xie, Tsinghua University, China
Chromatin Reprogramming in Mammalian Gametogenesis and Early Development


Wednesday, March 20 | 5:00PM - 7:15PM
Genome Architecture and Development
This session is from 3D Genome
Room: Van Horne C

Speaker 3 of 7
Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Genome Architecture Mapping: Discovering 3D Genome Topology in Rare Cell Types


Wednesday, March 20 | 5:00PM - 7:15PM
Genome Architecture and Development
This session is from 3D Genome
Room: Van Horne C

Speaker 4 of 7
X. Sunney Xie, Peking University, China
Decoding the 3D Human Genome


Wednesday, March 20 | 5:00PM - 7:15PM
Genome Architecture and Development
This session is from 3D Genome
Room: Van Horne C

Speaker 5 of 7
Sajad Hamid, University of California, San Francisco, USA
Short Talk: Mapping of Nuclear Lamina-Associated Genome Organization in Developing Mouse and Human Brain


Wednesday, March 20 | 5:00PM - 7:15PM
Genome Architecture and Development
This session is from 3D Genome
Room: Van Horne C

Speaker 6 of 7
Xiong Ji, Peking University, China
Short Talk: RNAPII Condensates Connect Genome Organization and Gene Regulation


Wednesday, March 20 | 5:00PM - 7:15PM
Genome Architecture and Development
This session is from 3D Genome
Room: Van Horne C

Speaker 7 of 7
Fulai Jin, Case Western Reserve University, USA
Short Talk: Multi-Scale 3D Genome Analyses in Human Neurogenesis and Brain Tissues with
Easy Hi-C


Wednesday, March 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Wednesday, March 20 | 7:30PM - 10:00PM
Poster Session 3
Room: Mezzanine 2


Thursday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Thursday, March 21 | 8:00AM - 11:15AM
Epigenetic Regulation in Immunoncology and Cancer Therapeuti
cs

Room: Van Horne A/B

Speaker 1 of 9
* Christopher Vakoc, Cold Spring Harbor Laboratory, USA

Thursday, March 21 | 8:00AM - 11:15AM
Epigenetic Regulation in Immunoncology and Cancer Therapeuti
cs

Room: Van Horne A/B

Speaker 2 of 9
Daniel De Carvalho, University Health Network, Canada
DNA Methylation, Viral Mimicry, Epigenetic Therapy

Thursday, March 21 | 8:00AM - 11:15AM
Epigenetic Regulation in Immunoncology and Cancer Therapeuti
cs

Room: Van Horne A/B

Speaker 3 of 9
Rab K. Prinjha, GlaxoSmithKline, UK
Drug Discovery and Clinical Progression or Epigenetic Therapies

Thursday, March 21 | 8:00AM - 11:15AM
Epigenetic Regulation in Immunoncology and Cancer Therapeuti
cs

Room: Van Horne A/B


Coffee Break

Thursday, March 21 | 8:00AM - 11:15AM
Epigenetic Regulation in Immunoncology and Cancer Therapeuti
cs

Room: Van Horne A/B

Speaker 5 of 9
Benjamin Nicholson, Merck Research Laboratories, USA
Epigenetics and Immune Modulation in Cancer

Thursday, March 21 | 8:00AM - 11:15AM
Epigenetic Regulation in Immunoncology and Cancer Therapeuti
cs

Room: Van Horne A/B

Speaker 6 of 9
Ricky W. Johnstone, Peter MacCallum Cancer Centre, Australia
Epigenetic Modulation of the Immune System for Cancer Treatment

Thursday, March 21 | 8:00AM - 11:15AM
Epigenetic Regulation in Immunoncology and Cancer Therapeuti
cs

Room: Van Horne A/B

Speaker 7 of 9
Alison A. Chomiak, Van Andel Research Institute, USA
Short Talk: Polycomb Signaling as a Therapeutic Axis for Enhancing Epigenetic Therapy in Colorectal Cancer

Thursday, March 21 | 8:00AM - 11:15AM
Epigenetic Regulation in Immunoncology and Cancer Therapeuti
cs

Room: Van Horne A/B

Speaker 8 of 9
Colum P. Walsh, University of Ulster, UK
Short Talk: UHRF1 Is Required to Suppress Viral Mimicry through Both DNA Methylation-Dependent and -Independent Mechanisms

Thursday, March 21 | 8:00AM - 11:15AM
Epigenetic Regulation in Immunoncology and Cancer Therapeuti
cs

Room: Van Horne A/B

Speaker 9 of 9
Andrew Morton, Case Western Reserve University, USA
Short Talk: Lineage-Specific Enhancers Are Co-Opted on Focal Oncogenic Amplifications in Solid Tumors

Thursday, March 21 | 8:00AM - 11:00AM
Computational Analysis of 3D Genome
This session is from 3D Genome
Room: Van Horne C

Speaker 1 of 9
* Bas van Steensel, Netherlands Cancer Institute, Netherlands


Thursday, March 21 | 8:00AM - 11:00AM
Computational Analysis of 3D Genome
This session is from 3D Genome
Room: Van Horne C

Speaker 2 of 9
David Hawkins, University of Washington, USA
Short Talk: Epigenome Annotation and Three-Dimensional Genome Architecture Reveal
Candidate Silencer Elements for the Human and Mouse Genomes


Thursday, March 21 | 8:00AM - 11:00AM
Computational Analysis of 3D Genome
This session is from 3D Genome
Room: Van Horne C

Speaker 3 of 9
Frank Alber, University California, Los Angeles, USA
Computational Modeling of 3D Genome


Thursday, March 21 | 8:00AM - 11:00AM
Computational Analysis of 3D Genome
This session is from 3D Genome
Room: Van Horne C

Speaker 4 of 9
Jill E. Moore, University of Massachusetts Medical School, USA
Short Talk: Evaluating Computational Methods for Predicting Enhancer-Gene Interactions


Thursday, March 21 | 8:00AM - 11:00AM
Computational Analysis of 3D Genome
This session is from 3D Genome
Room: Van Horne C


Coffee Break


Thursday, March 21 | 8:00AM - 11:00AM
Computational Analysis of 3D Genome
This session is from 3D Genome
Room: Van Horne C

Speaker 6 of 9
Mario Nicodemi, Universita' di Napoli Federico II, Italy
Polymer Physics Predicts the Effects of Structural Variants on Chromatin Architecture


Thursday, March 21 | 8:00AM - 11:00AM
Computational Analysis of 3D Genome
This session is from 3D Genome
Room: Van Horne C

Speaker 7 of 9
Ferhat Ay, La Jolla Institute, USA
Short Talk: FitHiChIP: Identification of Chromatin Loops from HiChIP/PLAC-Seq Data


Thursday, March 21 | 8:00AM - 11:00AM
Computational Analysis of 3D Genome
This session is from 3D Genome
Room: Van Horne C

Speaker 8 of 9
Kathleen Keough, Gladstone Institutes, University of California, San Francisco, USA
Short Talk: A Role for Enhancer Hijacking in the Emergence of Human Accelerated Regions


Thursday, March 21 | 8:00AM - 11:00AM
Computational Analysis of 3D Genome
This session is from 3D Genome
Room: Van Horne C

Speaker 9 of 9
R. Babak Faryabi, University of Pennsylvania, USA
Short Talk: Notch-Instructed 3D Cancer Genome


Thursday, March 21 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, March 21 | 11:30AM - 12:30PM
Roundtable Discussion: Careers in Industry (Joint)
Room: Conservatory


Thursday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, March 21 | 5:00PM - 7:00PM
3D Genome and Disease (Joint)
Room: Van Horne A/B

Speaker 1 of 7
* Mark A. Dawson, Peter MacCallum Cancer Centre, Australia

Thursday, March 21 | 5:00PM - 7:00PM
3D Genome and Disease (Joint)
Room: Van Horne A/B

Speaker 2 of 7
Joseph R. Ecker, The Salk Institute for Biological Studies, USA

Thursday, March 21 | 5:00PM - 7:00PM
3D Genome and Disease (Joint)
Room: Van Horne A/B

Speaker 3 of 7
Xiaowei Zhuang, Harvard University, USA
Single-Cell Transcriptome and Chromosome Imaging

Thursday, March 21 | 5:00PM - 7:00PM
3D Genome and Disease (Joint)
Room: Van Horne A/B

Speaker 4 of 7
Bradley E. Bernstein, Massachusetts General Hospital, USA
Epigenetic Plasticity and Selection in Tumorigenesis

Thursday, March 21 | 5:00PM - 7:00PM
3D Genome and Disease (Joint)
Room: Van Horne A/B

Speaker 5 of 7
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
TET Loss-of-Function and Oncogenesis

Thursday, March 21 | 5:00PM - 7:00PM
3D Genome and Disease (Joint)
Room: Van Horne A/B

Speaker 6 of 7
Zuzana Tothova, Dana-Farber Cancer Institute, USA
Short Talk: Chromatin Architecture in Leukemia through the Lens of Cohesin Complex Mutations

Thursday, March 21 | 5:00PM - 7:00PM
3D Genome and Disease (Joint)
Room: Van Horne A/B

Speaker 7 of 7
Jesse Dixon, The Salk Institute for Biological Studies, USA
Short Talk: Identification of Recurrent TAD Fusion Events as a Result of Structural Variation in Cancer Genomes

Thursday, March 21 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Joint)
Room: Van Horne A/B

Speaker 1 of 2
Anne Schaefer, Mount Sinai School of Medicine, USA

Thursday, March 21 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Joint)
Room: Van Horne A/B

Speaker 2 of 2
Joseph R. Ecker, The Salk Institute for Biological Studies, USA

Thursday, March 21 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Thursday, March 21 | 8:00PM - 11:00PM
Entertainment
Room: Mezzanine 2
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 21 | 8:00PM - 11:00PM
Cash Bar
Room: Mezzanine 2


Friday, March 22 | 10:24AM - 10:24AM
Departure


*Session Chair.