Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Cancer Epigenetics: New Mechanisms and Therapeutic Opportunities (2020J4)

Web Desc
Epigenetics and Human Disease joint with 3D Genome: Gene Regulation and Disease Organizer(s): Cheryl H. Arrowsmith, Anne Schaefer and Mark A. Dawson Date: March 17 - 21, 2019 Location: Fairmont Banff Springs, Banff, AB, Canada Sponsored by Cell Research, Incyte Corporation, Novartis Institutes for BioMedical Research and Pfizer Inc. Summary of Meeting: Epigenetics is a major mechanism in human health and disease. Data from a range of diseases (cancer, neurological and immunological disorders) have uncovered altered epigenomes arising from mutations, altered expression and/or copy number alterations of numerous epigenetic factors (histones, DNA and chromatin modifying enzymes, reader proteins, chromatin modulators and noncoding RNAs). Genome-wide analyses have illustrated the relationship between altered epigenetic states (e.g., modified DNA, histones and chromatin packaging) and disease onset and progression. Furthermore, both local and long-range nuclear chromatin architecture are increasingly recognized as major contributors to normal and pathologic epigenetic states. This conference, held jointly with a conference on “3D Genome”, will cover the most current knowledge of epigenetic events modulating nuclear function (gene expression regulation, enhancer modulation, domains and structural organization as well as cell division and differentiation), while relating this to normal and disease models. In addition, this conference will highlight the impact that preclinical and clinical epigenetic therapeutics have on multiple diseases including cancer, immunological and neurological disorders. An interdisciplinary panel of speakers including both thought leaders in the field as well as young investigators will survey the latest research results and conceptual understanding of fundamental mechanisms of epigenetic signaling, especially as they relate to regulation of gene expression programs. Presentations and workshops will highlight the latest technologies and methodologies for studying epigenetic states and 3D chromatin architecture in cells, tissues and organisms. Scholarship Deadline: November 29 2018 Discounted Abstract Deadline: November 29 2018 Abstract Deadline: December 12 2018 Discounted Registration Deadline: January 22 2019 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support from these exhibitors at this conference: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: GlaxoSmithKline We gratefully acknowledge the generous grant for this conference provided by: National Cancer Institute (NCI) Grant No. 1R13CA236128-01 Funding for this conference was made possible (in part) by 1R13CA236128-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Epigenetics and Human Disease

joint with 3D Genome: Gene Regulation and Disease

Organizer(s): Cheryl H. Arrowsmith, Anne Schaefer and Mark A. Dawson

Date: March 17 - 21, 2019
Location: Fairmont Banff Springs, Banff, AB, Canada

Sponsored by Cell Research, Incyte Corporation, Novartis Institutes for BioMedical Research and Pfizer Inc.

Summary of Meeting:

Epigenetics is a major mechanism in human health and disease. Data from a range of diseases (cancer, neurological and immunological disorders) have uncovered altered epigenomes arising from mutations, altered expression and/or copy number alterations of numerous epigenetic factors (histones, DNA and chromatin modifying enzymes, reader proteins, chromatin modulators and noncoding RNAs). Genome-wide analyses have illustrated the relationship between altered epigenetic states (e.g., modified DNA, histones and chromatin packaging) and disease onset and progression. Furthermore, both local and long-range nuclear chromatin architecture are increasingly recognized as major contributors to normal and pathologic epigenetic states. This conference, held jointly with a conference on “3D Genome”, will cover the most current knowledge of epigenetic events modulating nuclear function (gene expression regulation, enhancer modulation, domains and structural organization as well as cell division and differentiation), while relating this to normal and disease models. In addition, this conference will highlight the impact that preclinical and clinical epigenetic therapeutics have on multiple diseases including cancer, immunological and neurological disorders. An interdisciplinary panel of speakers including both thought leaders in the field as well as young investigators will survey the latest research results and conceptual understanding of fundamental mechanisms of epigenetic signaling, especially as they relate to regulation of gene expression programs. Presentations and workshops will highlight the latest technologies and methodologies for studying epigenetic states and 3D chromatin architecture in cells, tissues and organisms.

Scholarship Deadline: November 29 2018

Discounted Abstract Deadline: November 29 2018

Abstract Deadline: December 12 2018

Discounted Registration Deadline: January 22 2019

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support from these exhibitors at this conference:

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline

We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA236128-01
Funding for this conference was made possible (in part) by 1R13CA236128-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, March 17 \| 4:00PM - 8:00PM Arrival and Registration Room: Van Horne Foyer
Sunday, March 17 \| 6:00PM - 8:00PM Welcome Mixer Room: Van Horne Foyer No registration fees are used to fund alcohol served at this function.
Monday, March 18 \| 7:00AM - 8:00AM Breakfast Room: Mezzanine 2
Monday, March 18 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Van Horne A/B Speaker 1 of 5 * Cheryl Arrowsmith, University of Toronto, Canada
Monday, March 18 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Van Horne A/B Speaker 2 of 5 * Bing Ren, Ludwig Institute for Cancer Research, USA
Monday, March 18 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Van Horne A/B Speaker 3 of 5 Richard A. Young, Whitehead Institute for Biomedical Research, USA Transcriptional Regulation, Epigenetics and Disease
Monday, March 18 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Van Horne A/B Speaker 4 of 5 Wendy A. Bickmore, University of Edinburgh, UK Spatial Organization of the Human Genome in Disease and Senescence
Monday, March 18 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Van Horne A/B Coffee Break
Monday, March 18 \| 9:50AM - 12:15PM 3D Epigenome/Epigenetics and Disease (Joint) Room: Van Horne A/B Speaker 1 of 7 * Anne Schaefer, Mount Sinai School of Medicine, USA
Monday, March 18 \| 9:50AM - 12:15PM 3D Epigenome/Epigenetics and Disease (Joint) Room: Van Horne A/B Speaker 2 of 7 Matthias Merkenschlager, Imperial College London, UK Quantitative Approaches to Cohesin-Dependent Regulation of Transcription
Monday, March 18 \| 9:50AM - 12:15PM 3D Epigenome/Epigenetics and Disease (Joint) Room: Van Horne A/B Speaker 3 of 7 Mathieu Lupien, University Health Network, Canada Epigenetics Variants in Cancer
Monday, March 18 \| 9:50AM - 12:15PM 3D Epigenome/Epigenetics and Disease (Joint) Room: Van Horne A/B Speaker 4 of 7 Joanna Wysocka, Stanford University, USA Epigenetic Regulation of Craniofacial Development
Monday, March 18 \| 9:50AM - 12:15PM 3D Epigenome/Epigenetics and Disease (Joint) Room: Van Horne A/B Speaker 5 of 7 John Alan Wildenthal, NCI, National Institutes of Health, USA Short Talk: Elucidating Enhancers Governing Human Pancreas Cell Identity and Function
Monday, March 18 \| 9:50AM - 12:15PM 3D Epigenome/Epigenetics and Disease (Joint) Room: Van Horne A/B Speaker 6 of 7 Yin Shen, University of California, San Francisco, USA Short Talk: Charting Cell-Specific 3D Epigenomes during Corticogenesis to Understand Human Brain Development and Complex Disorders
Monday, March 18 \| 9:50AM - 12:15PM 3D Epigenome/Epigenetics and Disease (Joint) Room: Van Horne A/B Speaker 7 of 7 Evgeny Kvon, Lawrence Berkeley National Laboratory, USA Short Talk: Saturation Mutagenesis Reveals Functional Impact of Enhancer Mutations in vivo
Monday, March 18 \| 12:15PM - 5:00PM On Own for Lunch
Monday, March 18 \| 12:15PM - 1:00PM Poster Setup Room: Mezzanine 2
Monday, March 18 \| 1:00PM - 10:00PM Poster Viewing Room: Mezzanine 2
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: Epigenetic Memory and Inheritance in Health and Disease Room: Van Horne A/B Speaker 1 of 8 * Mathieu Lupien, University Health Network, Canada
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: Epigenetic Memory and Inheritance in Health and Disease Room: Van Horne A/B Speaker 2 of 8 Berkley Eric Gryder, NCI, National Institutes of Health, USA Chemical Disruption of Core Regulatory Architecture in Rhabdomyosarcoma
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: Epigenetic Memory and Inheritance in Health and Disease Room: Van Horne A/B Speaker 3 of 8 Navneet Matharu, University of California, San Francisco, USA CRISPRa-Mediated Activation of Promoter or Enhancer Corrects Haploinsufficiency
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: Epigenetic Memory and Inheritance in Health and Disease Room: Van Horne A/B Speaker 4 of 8 Benjamin A. Nacev, Memorial Sloan Kettering Cancer Center, USA Expanding the Landscape of 'Oncohistone' Mutations in Human Cancers
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: Epigenetic Memory and Inheritance in Health and Disease Room: Van Horne A/B Speaker 5 of 8 Kirsten C. Sadler, New York University Abu Dhabi, United Arab Emirates Epigenetic Compensation Promotes Liver Regeneration
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: Epigenetic Memory and Inheritance in Health and Disease Room: Van Horne A/B Speaker 6 of 8 Shu-Ping Wang, Academia Sinica, Taiwan Critical Roles of the MLL4 Complex in Establishing an Active Enhancer Landscape in Normal and Pathological Conditions
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: Epigenetic Memory and Inheritance in Health and Disease Room: Van Horne A/B Speaker 7 of 8 Yael David, Memorial Sloan Kettering Cancer Center, USA Reversible Histone Glycation Drives Cancer- Associated Changes in Chromatin Architecture
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: Epigenetic Memory and Inheritance in Health and Disease Room: Van Horne A/B Speaker 8 of 8 Joel B. Berletch, University of Washington, USA Differential Epigenetic Regulation of Maternal and Paternal Alleles by the Histone Demethylase KDM6A
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: 4DN Nucleome Consortium Resources This session is from 3D Genome Room: Van Horne C In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them. Speaker 1 of 8 Judy Mietz, NCI, National Institutes of Health, USA 4DN Current Scope and Outlook
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: 4DN Nucleome Consortium Resources This session is from 3D Genome Room: Van Horne C In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them. Speaker 2 of 8 Olivier Blondel, NIDDK, National Institutes of Health, USA 4DN Current Scope and Outlook
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: 4DN Nucleome Consortium Resources This session is from 3D Genome Room: Van Horne C In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them. Speaker 3 of 8 Burak H. Alver, Harvard Medical School, USA 4DN Data Portal
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: 4DN Nucleome Consortium Resources This session is from 3D Genome Room: Van Horne C In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them. Speaker 4 of 8 Feng Yue, Pennsylvania State University, USA Introduction to 4DN Joint Analysis
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: 4DN Nucleome Consortium Resources This session is from 3D Genome Room: Van Horne C In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them. Speaker 5 of 8 Nick Gilbert, University of Edinburgh, UK Chromatin-Associated RNA Recycling by XRN2 Regulates Transcription and Chromosome Structure
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: 4DN Nucleome Consortium Resources This session is from 3D Genome Room: Van Horne C In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them. Speaker 6 of 8 Rieke Kempfer, Max Delbrück Center, Germany Higher-Order Chromatin Contacts and Regulatory Networks in the ESC Genome.
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: 4DN Nucleome Consortium Resources This session is from 3D Genome Room: Van Horne C In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them. Speaker 7 of 8 * Sheng Zhong, University of California, San Diego, USA RNA as Proximity Labeling Media for Connecting Microscopic and Omics Data of Nuclear Organization
Monday, March 18 \| 2:30PM - 4:30PM Workshop 1: 4DN Nucleome Consortium Resources This session is from 3D Genome Room: Van Horne C In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them. Speaker 8 of 8 Zhen Chen, City of Hope, USA Endothelial Functional Regulation by Enhancer-Associated Long Non-Coding RNAs
Monday, March 18 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Monday, March 18 \| 5:00PM - 7:00PM Epigenetic Dysregulation in Neurobiology Room: Van Horne A/B Speaker 1 of 6 * Wendy A. Bickmore, University of Edinburgh, UK
Monday, March 18 \| 5:00PM - 7:00PM Epigenetic Dysregulation in Neurobiology Room: Van Horne A/B Speaker 2 of 6 Anne Schaefer, Mount Sinai School of Medicine, USA Epigenetic Regulation of Neurodevelopment and Neurodegeneration
Monday, March 18 \| 5:00PM - 7:00PM Epigenetic Dysregulation in Neurobiology Room: Van Horne A/B Speaker 3 of 6 Danny F. Reinberg, HHMI/New York University, USA The Epigenetic Status of Some Histone Post-Translational Modifications
Monday, March 18 \| 5:00PM - 7:00PM Epigenetic Dysregulation in Neurobiology Room: Van Horne A/B Speaker 4 of 6 Shelley L. Berger, University of Pennsylvania, USA Epigenetic Pathways as Targets in Human Cancer
Monday, March 18 \| 5:00PM - 7:00PM Epigenetic Dysregulation in Neurobiology Room: Van Horne A/B Speaker 5 of 6 Gonçalo Castelo-Branco, Karolinska Institutet, Sweden Short Talk: Single-Cell Transcriptomics and Epigenomics Reveal Disease-Specific States of Oligodendroglia in Multiple Sclerosis
Monday, March 18 \| 5:00PM - 7:00PM Epigenetic Dysregulation in Neurobiology Room: Van Horne A/B Speaker 6 of 6 Lorna Farrelly, Icahn School of Medicine at Mount Sinai, USA Short Talk: Glutamine 5 Serotonylation on Histone H3 Is a Permissive Modification that Functions Combinatorially with H3K4me3 to Potentiate Gene Expression
Monday, March 18 \| 5:00PM - 7:30PM Single Cell Analysis of Genome Architecture This session is from 3D Genome Room: Van Horne C Speaker 1 of 8 * Xiaowei Zhuang, Harvard University, USA
Monday, March 18 \| 5:00PM - 7:30PM Single Cell Analysis of Genome Architecture This session is from 3D Genome Room: Van Horne C Speaker 2 of 8 Alistair Boettiger, Stanford University, USA Visualizing 3D Genome Architecture and Gene Expression during Embryogenesis
Monday, March 18 \| 5:00PM - 7:30PM Single Cell Analysis of Genome Architecture This session is from 3D Genome Room: Van Horne C Speaker 3 of 8 Peter Fraser, Florida State University, USA Cell Cycle Dynamics of Chromosomal Organization at Single-Cell Resolution
Monday, March 18 \| 5:00PM - 7:30PM Single Cell Analysis of Genome Architecture This session is from 3D Genome Room: Van Horne C Speaker 4 of 8 Ibrahim Cissé, Massachusetts Institute of Technology, USA Super-Resolution Imaging of Transcription in Live Mammalian Cells
Monday, March 18 \| 5:00PM - 7:30PM Single Cell Analysis of Genome Architecture This session is from 3D Genome Room: Van Horne C Speaker 5 of 8 Blanca Pijuan-Sala, University of Cambridge, UK Short Talk: Using Single-Cell Chromatin Accessibility Profiling to Study the Regulatory Mechanisms Underlying Early Mouse Organogenesis
Monday, March 18 \| 5:00PM - 7:30PM Single Cell Analysis of Genome Architecture This session is from 3D Genome Room: Van Horne C Speaker 6 of 8 Akihito Harada, Kyushu University, Japan Short Talk: High-Throughput Single Cell Epigenomic Profiling using Chromatin Integration Labeling-Sequence
Monday, March 18 \| 5:00PM - 7:30PM Single Cell Analysis of Genome Architecture This session is from 3D Genome Room: Van Horne C Speaker 7 of 8 Seungsoo Kim, University of Washington, USA Short Talk: A Combination of Transcription Factors Mediates Inducible Interchromosomal Contacts
Monday, March 18 \| 5:00PM - 7:30PM Single Cell Analysis of Genome Architecture This session is from 3D Genome Room: Van Horne C Speaker 8 of 8 Jesse M. Engreitz, Harvard University and Broad Institute, USA Short Talk: Activity-by-Contact Model of Enhancer Specificity from Thousands of CRISPR Perturbations
Monday, March 18 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Mezzanine 2 No registration fees are used to fund alcohol served at this function.
Monday, March 18 \| 7:30PM - 10:00PM Poster Session 1 Room: Mezzanine 2
Tuesday, March 19 \| 7:00AM - 8:00AM Breakfast Room: Mezzanine 2
Tuesday, March 19 \| 8:00AM - 11:15AM Understanding and Targeting Epigenetic Dysregulation Room: Van Horne A/B Speaker 1 of 9 * Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA
Tuesday, March 19 \| 8:00AM - 11:15AM Understanding and Targeting Epigenetic Dysregulation Room: Van Horne A/B Speaker 2 of 9 Mark A. Dawson, Peter MacCallum Cancer Centre, Australia Mechanisms of Epigenetic Therapeutics in Leukemia
Tuesday, March 19 \| 8:00AM - 11:15AM Understanding and Targeting Epigenetic Dysregulation Room: Van Horne A/B Speaker 3 of 9 Johannes Zuber, Research Institute of Molecular Pathology, Austria Decoding Transcriptional Dependencies in Leukemia
Tuesday, March 19 \| 8:00AM - 11:15AM Understanding and Targeting Epigenetic Dysregulation Room: Van Horne A/B Coffee Break
Tuesday, March 19 \| 8:00AM - 11:15AM Understanding and Targeting Epigenetic Dysregulation Room: Van Horne A/B Speaker 5 of 9 Cheryl Arrowsmith, University of Toronto, Canada Probing the Epigenome for Therapeutic Opportunities
Tuesday, March 19 \| 8:00AM - 11:15AM Understanding and Targeting Epigenetic Dysregulation Room: Van Horne A/B Speaker 6 of 9 Marie Classon, USA Epigenetic Mechanisms of Drug Resistance
Tuesday, March 19 \| 8:00AM - 11:15AM Understanding and Targeting Epigenetic Dysregulation Room: Van Horne A/B Speaker 7 of 9 Sarah Attwell, Zenith Epigenetics Corp., Canada Short Talk: The BET Inhibitor ZEN-3694 Blocks Multiple Tumor Immune Suppressive Factors and Has the Potential to Increase the Efficacy of Anti-PD1 Treatment
Tuesday, March 19 \| 8:00AM - 11:15AM Understanding and Targeting Epigenetic Dysregulation Room: Van Horne A/B Speaker 8 of 9 M. Ryan Corces, Stanford University, USA Short Talk: The Chromatin Accessibility Landscape of Primary Human Cancers
Tuesday, March 19 \| 8:00AM - 11:15AM Understanding and Targeting Epigenetic Dysregulation Room: Van Horne A/B Speaker 9 of 9 Céline Vallot, Institut Curie, France Short Talk: Single-Cell Chromatin Profiling Reveals Heterogeneity of Chromatin States in Breast Cancer
Tuesday, March 19 \| 8:00AM - 11:00AM Analysis of 3D Genome with Advanced Microscopy This session is from 3D Genome Room: Van Horne C Speaker 1 of 8 * Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Tuesday, March 19 \| 8:00AM - 11:00AM Analysis of 3D Genome with Advanced Microscopy This session is from 3D Genome Room: Van Horne C Speaker 2 of 8 Cornelis Murre, University of California, San Diego, USA The Role of Non-Coding Transcription in Compartmentalization
Tuesday, March 19 \| 8:00AM - 11:00AM Analysis of 3D Genome with Advanced Microscopy This session is from 3D Genome Room: Van Horne C Speaker 3 of 8 Andrew S. Belmont, University of Illinois at Urbana-Champaign, USA Nuclear Speckle Association Modulates Transcription Revealed through Live-Cell Imaging
Tuesday, March 19 \| 8:00AM - 11:00AM Analysis of 3D Genome with Advanced Microscopy This session is from 3D Genome Room: Van Horne C Coffee Break
Tuesday, March 19 \| 8:00AM - 11:00AM Analysis of 3D Genome with Advanced Microscopy This session is from 3D Genome Room: Van Horne C Speaker 5 of 8 Hanhui Ma, Shanghaitech University, China Short Talk: “CRISPRadius” Reveals that DNA and Histone Modifications Cooperatively Regulate Heterochromatin Condensates
Tuesday, March 19 \| 8:00AM - 11:00AM Analysis of 3D Genome with Advanced Microscopy This session is from 3D Genome Room: Van Horne C Speaker 6 of 8 Clodagh C. O'Shea, The Salk Institute for Biological Studies, USA Cracking the Nucleus: Visualizing the Higher Coding Structures of DNA
Tuesday, March 19 \| 8:00AM - 11:00AM Analysis of 3D Genome with Advanced Microscopy This session is from 3D Genome Room: Van Horne C Speaker 7 of 8 Magda Bienko, Karolinska Institutet, Sweden Short Talk: Radial Organization of the Genome Revealed by GPSeq
Tuesday, March 19 \| 8:00AM - 11:00AM Analysis of 3D Genome with Advanced Microscopy This session is from 3D Genome Room: Van Horne C Speaker 8 of 8 Erez Lieberman-Aiden, Baylor College of Medicine, USA Tracking Genome Architecture in Space, in Time and in Single Cells
Tuesday, March 19 \| 11:15AM - 5:00PM On Own for Lunch
Tuesday, March 19 \| 11:15AM - 1:00PM Poster Setup Room: Mezzanine 2
Tuesday, March 19 \| 1:00PM - 10:00PM Poster Viewing Room: Mezzanine 2
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: Novel Modifications of Chromatin & RNA: Detectio n, Quantification and Functional Significance Room: Van Horne A/B Speaker 1 of 6 * François Fuks, Université Libre de Bruxelles, Belgium Transcriptome-Wide Distribution and Function of RNA Modifications
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: Novel Modifications of Chromatin & RNA: Detectio n, Quantification and Functional Significance Room: Van Horne A/B Speaker 2 of 6 Adriana Z. Corvalan, University of California, Los Angeles, USA Understanding the Role of H4K20me3 and Suv4-20h2 in Cellular Quiescence
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: Novel Modifications of Chromatin & RNA: Detectio n, Quantification and Functional Significance Room: Van Horne A/B Speaker 3 of 6 Harrison W. Gabel, Washington University School of Medicine, USA Non-CG DNA Methylation in Neurodevelopmental Disorders
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: Novel Modifications of Chromatin & RNA: Detectio n, Quantification and Functional Significance Room: Van Horne A/B Speaker 4 of 6 Simão Teixeira Rocha, Instituto de Medicina Molecular Joao Lobo Antunes, Portugal Exploring the Role of Polycomb Recruitment in Xist-Mediated Silencing of the X Chromosome in ES Cells
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: Novel Modifications of Chromatin & RNA: Detectio n, Quantification and Functional Significance Room: Van Horne A/B Speaker 5 of 6 Rohan Nishant Shah, University of Chicago, USA Quantitative Studies of Histone Modifications
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: Novel Modifications of Chromatin & RNA: Detectio n, Quantification and Functional Significance Room: Van Horne A/B Speaker 6 of 6 Zibo Zhao, Northwestern University, USA Regulation of MLL/COMPASS Stability Through Its Proteolytic Cleavage by Taspase1 as a Possible Approach for Clinical Therapy of Leukemia
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: ENCODE Consortium Resources This session is from 3D Genome Room: Van Horne C The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium. Speaker 1 of 8 * Feng Yue, Pennsylvania State University, USA
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: ENCODE Consortium Resources This session is from 3D Genome Room: Van Horne C The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium. Speaker 2 of 8 Michael J. Pazin, NHGRI, National Institutes of Health, USA Overview of ENCODE Project
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: ENCODE Consortium Resources This session is from 3D Genome Room: Van Horne C The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium. Speaker 3 of 8 Zhiping Weng, University of Massachusetts, USA ENCODE DAC
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: ENCODE Consortium Resources This session is from 3D Genome Room: Van Horne C The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium. Speaker 4 of 8 Jason Hilton, Stanford University, USA ENCODE DAC
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: ENCODE Consortium Resources This session is from 3D Genome Room: Van Horne C The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium. Speaker 5 of 8 Jian Ma, Carnegie Mellon University, USA Comparing 3D Genome Organization in Multiple Species using Phylo-HMRF
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: ENCODE Consortium Resources This session is from 3D Genome Room: Van Horne C The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium. Speaker 6 of 8 Yanxiao Zhang, Ludwig Institute for Cancer Research, USA Primate-Specific Retrotransposon HERV-H Demarcates Chromatin Domains in Lineage Specification and Evolution
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: ENCODE Consortium Resources This session is from 3D Genome Room: Van Horne C The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium. Speaker 7 of 8 Joe Spidle, Arima Genomics, Inc., USA Rapid and Sensitive Discovery of Genomic Interactions using Arima-HiC
Tuesday, March 19 \| 2:30PM - 4:30PM Workshop 2: ENCODE Consortium Resources This session is from 3D Genome Room: Van Horne C The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium. Speaker 8 of 8 Michael Christopher Keogh, EpiCypher Inc, USA Fixing ChIP with Next-Generation Spike-In Controls
Tuesday, March 19 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Tuesday, March 19 \| 5:00PM - 7:00PM Infectious Diseases and Autoimmunity Room: Van Horne A/B Speaker 1 of 6 * Rab K. Prinjha, GlaxoSmithKline, UK
Tuesday, March 19 \| 5:00PM - 7:00PM Infectious Diseases and Autoimmunity Room: Van Horne A/B Speaker 2 of 6 Eric A. Miska, University of Cambridge, UK RNA Modifications and Novel Antiviral Response
Tuesday, March 19 \| 5:00PM - 7:00PM Infectious Diseases and Autoimmunity Room: Van Horne A/B Speaker 3 of 6 Alexander Tarakhovsky, Rockefeller University, USA I-BET, Inflammation, Histone Mimicry in Pathogens, Antiviral Response
Tuesday, March 19 \| 5:00PM - 7:00PM Infectious Diseases and Autoimmunity Room: Van Horne A/B Speaker 4 of 6 Madle Sirel, Karolinska Institutet, Sweden Short Talk: Epigenetics of Parasites Causing Placental Malaria
Tuesday, March 19 \| 5:00PM - 7:00PM Infectious Diseases and Autoimmunity Room: Van Horne A/B Speaker 5 of 6 Colby Zaph, Monash University, Australia Regulatory T Cell Stability Is Controlled by the Lysine Methyltransferase G9a Independently of DNA Methylation
Tuesday, March 19 \| 5:00PM - 7:00PM Infectious Diseases and Autoimmunity Room: Van Horne A/B Speaker 6 of 6 Timothy M. Johanson, Walter and Eliza Hall Institute of Medical Research, Australia Short Talk: Pax5 Organizes the B Cell Genome in Three-Dimensions Independent of Transcription
Tuesday, March 19 \| 5:00PM - 7:15PM Chromatin and Epigenetics This session is from 3D Genome Room: Van Horne C Speaker 1 of 7 * X. Shirley Liu, Dana-Farber Cancer Institute, USA
Tuesday, March 19 \| 5:00PM - 7:15PM Chromatin and Epigenetics This session is from 3D Genome Room: Van Horne C Speaker 2 of 7 Bas van Steensel, Netherlands Cancer Institute, Netherlands Rewiring of LADs by Transcription
Tuesday, March 19 \| 5:00PM - 7:15PM Chromatin and Epigenetics This session is from 3D Genome Room: Van Horne C Speaker 3 of 7 Mitchell Guttman, California Institute of Technology, USA 3D Genome Organization and X Chromosome Inactivation
Tuesday, March 19 \| 5:00PM - 7:15PM Chromatin and Epigenetics This session is from 3D Genome Room: Van Horne C Speaker 4 of 7 Joseph R. Ecker, The Salk Institute for Biological Studies, USA Single Cell Analysis of DNA Methylation
Tuesday, March 19 \| 5:00PM - 7:15PM Chromatin and Epigenetics This session is from 3D Genome Room: Van Horne C Speaker 5 of 7 Chen-Yu Wang, Massachusetts General Hospital, USA Short Talk: SMCHD1 Regulates the Folding of the Inactive X Chromosome and Select Autosomal loci
Tuesday, March 19 \| 5:00PM - 7:15PM Chromatin and Epigenetics This session is from 3D Genome Room: Van Horne C Speaker 6 of 7 Candice Byers, Tufts University, USA Short Talk: Cellular Systems Genetics Implicates KRAB Zinc Finger Proteins in Mediating Variation in Chromatin State in Pluripotent Stem Cells
Tuesday, March 19 \| 5:00PM - 7:15PM Chromatin and Epigenetics This session is from 3D Genome Room: Van Horne C Speaker 7 of 7 Marc Bühler, Friedrich Miescher Institute for Biomedical Research, Switzerland Short Talk: A Transcription Factor Implicated in Autism Locally Constrains Chromatin Looping
Tuesday, March 19 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Mezzanine 2 No registration fees are used to fund alcohol served at this function.
Tuesday, March 19 \| 7:30PM - 10:00PM Poster Session 2 Room: Mezzanine 2
Wednesday, March 20 \| 7:00AM - 8:00AM Breakfast Room: Mezzanine 2
Wednesday, March 20 \| 8:00AM - 11:15AM Chromatin Signaling and Epigenetic Mechanisms Room: Van Horne A/B Speaker 1 of 9 * Anne Brunet, Stanford University, USA
Wednesday, March 20 \| 8:00AM - 11:15AM Chromatin Signaling and Epigenetic Mechanisms Room: Van Horne A/B Speaker 2 of 9 Christopher Vakoc, Cold Spring Harbor Laboratory, USA Transcriptional Addiction in Cancer
Wednesday, March 20 \| 8:00AM - 11:15AM Chromatin Signaling and Epigenetic Mechanisms Room: Van Horne A/B Speaker 3 of 9 Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School, USA Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease
Wednesday, March 20 \| 8:00AM - 11:15AM Chromatin Signaling and Epigenetic Mechanisms Room: Van Horne A/B Coffee Break
Wednesday, March 20 \| 8:00AM - 11:15AM Chromatin Signaling and Epigenetic Mechanisms Room: Van Horne A/B Speaker 5 of 9 Paola Scaffidi, Francis Crick Institute, UK Epigenetics and Functional Intratumor Heterogeneity
Wednesday, March 20 \| 8:00AM - 11:15AM Chromatin Signaling and Epigenetic Mechanisms Room: Van Horne A/B Speaker 6 of 9 Xiaobing Shi, Van Andel Institute, USA Identification of the ZZ Domain as a Novel Histone Reader
Wednesday, March 20 \| 8:00AM - 11:15AM Chromatin Signaling and Epigenetic Mechanisms Room: Van Horne A/B Speaker 7 of 9 Kelly Barnett, Vanderbilt University, USA Short Talk: ATAC-Me Captures Spatiotemporal Dynamics of DNA Methylation Across the Chromatin Accessible Genome during a Monocyte-to-Macrophage Transition
Wednesday, March 20 \| 8:00AM - 11:15AM Chromatin Signaling and Epigenetic Mechanisms Room: Van Horne A/B Speaker 8 of 9 Susan J. Clark, Garvan Institute of Medical Research, Australia Short Talk: DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Mono-Methylation Patterns
Wednesday, March 20 \| 8:00AM - 11:15AM Chromatin Signaling and Epigenetic Mechanisms Room: Van Horne A/B Speaker 9 of 9 Hatice S. Kaya-Okur, Fred Hutchinson Cancer Research Center, USA Short Talk: CUT&Tag for Efficient Epigenomic Profiling of Small Samples and Single Cells
Wednesday, March 20 \| 8:00AM - 11:00AM 3D Genome and Gene Regulation This session is from 3D Genome Room: Van Horne C Speaker 1 of 7 * Mathieu Lupien, University Health Network, Canada
Wednesday, March 20 \| 8:00AM - 11:00AM 3D Genome and Gene Regulation This session is from 3D Genome Room: Van Horne C Speaker 2 of 7 Bing Ren, Ludwig Institute for Cancer Research, USA Systematic Identification and Characterization of Promoter-Enhancer Interactions in the Human Genome
Wednesday, March 20 \| 8:00AM - 11:00AM 3D Genome and Gene Regulation This session is from 3D Genome Room: Van Horne C Speaker 3 of 7 Gerd A. Blobel, Children's Hospital of Philadelphia, USA Re-Configuration of Chromatin Structure During the Mitosis-G1 Phase Transition
Wednesday, March 20 \| 8:00AM - 11:00AM 3D Genome and Gene Regulation This session is from 3D Genome Room: Van Horne C Coffee Break
Wednesday, March 20 \| 8:00AM - 11:00AM 3D Genome and Gene Regulation This session is from 3D Genome Room: Van Horne C Speaker 5 of 7 Jennifer E. Phillips-Cremins, University of Pennsylvania, USA LADL: Light-Activated Dynamic Looping for Endogenous Gene Expression Control
Wednesday, March 20 \| 8:00AM - 11:00AM 3D Genome and Gene Regulation This session is from 3D Genome Room: Van Horne C Speaker 6 of 7 Stavros Lomvardas, Columbia University, USA 3D Chromatin Organization of the Olfactory Receptor Locus
Wednesday, March 20 \| 8:00AM - 11:00AM 3D Genome and Gene Regulation This session is from 3D Genome Room: Van Horne C Speaker 7 of 7 X. Shirley Liu, Dana-Farber Cancer Institute, USA Epigenomic Analysis of Cancer Cells
Wednesday, March 20 \| 11:15AM - 5:00PM On Own for Lunch
Wednesday, March 20 \| 11:15AM - 1:00PM Poster Setup Room: Mezzanine 2
Wednesday, March 20 \| 11:30AM - 12:30PM Roundtable Discussion: Women in Science (Joint) Room: Conservatory
Wednesday, March 20 \| 1:00PM - 10:00PM Poster Viewing Room: Mezzanine 2
Wednesday, March 20 \| 2:30PM - 4:30PM Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin g Enzymes Room: Van Horne A/B Speaker 1 of 7 * Nada Jabado, McGill University Health Centre, Canada Therapeutic Vulnerability of the K27M Oncohistone: Finding Achilles' Heel in Gliomas?
Wednesday, March 20 \| 2:30PM - 4:30PM Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin g Enzymes Room: Van Horne A/B Speaker 2 of 7 Danielle Bozek, University of Calgary, Canada DOT1L Epigenetically Regulates Glioblastoma Cancer Stem Cell Properties
Wednesday, March 20 \| 2:30PM - 4:30PM Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin g Enzymes Room: Van Horne A/B Speaker 3 of 7 Patrizia Casaccia, Advanced Science Research Center, USA DNA Hydroxymethylation Impacts Age-Dependent Myelin Regeneration in the Central Nervous System
Wednesday, March 20 \| 2:30PM - 4:30PM Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin g Enzymes Room: Van Horne A/B Speaker 4 of 7 Bilal N. Sheikh, Max Planck Institute for Immunobiology and Epigenetics, Germany Neural Metabolic Defects Lead to Inflammation and Brain Haemorrhage
Wednesday, March 20 \| 2:30PM - 4:30PM Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin g Enzymes Room: Van Horne A/B Speaker 5 of 7 Gabriel Oh, Centre for Addiction and Mental Health, Canada Circadian DNA Modification Hallmarks of Aging and Disease
Wednesday, March 20 \| 2:30PM - 4:30PM Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin g Enzymes Room: Van Horne A/B Speaker 6 of 7 Andreas R. Pfenning, Carnegie Mellon University, USA Epigenomic Profiling of Major Human Brain Cell Types Reveals Sex Specific Differences in Hippocampal Oligodendrocyte Gene Regulation in Alzheimer's Disease
Wednesday, March 20 \| 2:30PM - 4:30PM Workshop 3: Emerging Therapies to Chromatin and RNA Modifyin g Enzymes Room: Van Horne A/B Speaker 7 of 7 Emmanuelle Vire, University College London, UK Altered DNA Methylation Signatures to Better Detect, Classify, and Understand Human Prion Diseases
Wednesday, March 20 \| 2:30PM - 4:30PM Workshop 3: International Human Epigenome Consortium This session is from 3D Genome Room: Van Horne C The IHEC consortium is an international consortium of investigators dedicated to the study of epigenomes in normal and disease cells. It has made major contributions to the development of new technologies and generation of valuable datasets to the field of epigenomics. This workshop will feature short presentations and tutorials aimed at facilitating the dissemination of resources and tools from the IHEC consortium. Speaker 1 of 5 Martin Hirst, BC Cancer Agency, Canada Introduction to International Human Epigenome Consortium
Wednesday, March 20 \| 2:30PM - 4:30PM Workshop 3: International Human Epigenome Consortium This session is from 3D Genome Room: Van Horne C The IHEC consortium is an international consortium of investigators dedicated to the study of epigenomes in normal and disease cells. It has made major contributions to the development of new technologies and generation of valuable datasets to the field of epigenomics. This workshop will feature short presentations and tutorials aimed at facilitating the dissemination of resources and tools from the IHEC consortium. Speaker 2 of 5 David Bujold, McGill University, Canada Epigenomic Data Discovery with the IHEC Data Portal
Wednesday, March 20 \| 2:30PM - 4:30PM Workshop 3: International Human Epigenome Consortium This session is from 3D Genome Room: Van Horne C The IHEC consortium is an international consortium of investigators dedicated to the study of epigenomes in normal and disease cells. It has made major contributions to the development of new technologies and generation of valuable datasets to the field of epigenomics. This workshop will feature short presentations and tutorials aimed at facilitating the dissemination of resources and tools from the IHEC consortium. Speaker 3 of 5 Charles Dupras, McGill University, Canada Potential (Mis)use of Epigenetic Age Estimators by Private Companies and Public Agencies: Are Legal Safeguards Required?
Wednesday, March 20 \| 2:30PM - 4:30PM Workshop 3: International Human Epigenome Consortium This session is from 3D Genome Room: Van Horne C The IHEC consortium is an international consortium of investigators dedicated to the study of epigenomes in normal and disease cells. It has made major contributions to the development of new technologies and generation of valuable datasets to the field of epigenomics. This workshop will feature short presentations and tutorials aimed at facilitating the dissemination of resources and tools from the IHEC consortium. Speaker 4 of 5 * Danny C.Y. Leung, Hong Kong University of Science and Technology, Hong Kong Epigenomic Analyses of Retrotransposon-Derived cis-Regulatory Elements in Distinct Human Cell-Types
Wednesday, March 20 \| 2:30PM - 4:30PM Workshop 3: International Human Epigenome Consortium This session is from 3D Genome Room: Van Horne C The IHEC consortium is an international consortium of investigators dedicated to the study of epigenomes in normal and disease cells. It has made major contributions to the development of new technologies and generation of valuable datasets to the field of epigenomics. This workshop will feature short presentations and tutorials aimed at facilitating the dissemination of resources and tools from the IHEC consortium. Speaker 5 of 5 Martin Hirst, BC Cancer Agency, Canada Polycomb Contraction during Human Granulopoietic Lineage Restriction
Wednesday, March 20 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Wednesday, March 20 \| 5:00PM - 7:00PM Metabolic Diseases and Aging Room: Van Horne A/B Speaker 1 of 6 * Shelley L. Berger, University of Pennsylvania, USA
Wednesday, March 20 \| 5:00PM - 7:00PM Metabolic Diseases and Aging Room: Van Horne A/B Speaker 2 of 6 Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA Role of Mutations in Epigenetic Regulators in Pathogenesis of AML
Wednesday, March 20 \| 5:00PM - 7:00PM Metabolic Diseases and Aging Room: Van Horne A/B Speaker 3 of 6 Stefan Horvath, University of California, Los Angeles, USA Epigenetic Aging Clock versus Gene Regulation
Wednesday, March 20 \| 5:00PM - 7:00PM Metabolic Diseases and Aging Room: Van Horne A/B Speaker 4 of 6 Anne Brunet, Stanford University, USA Epigenetic Regulation of Aging
Wednesday, March 20 \| 5:00PM - 7:00PM Metabolic Diseases and Aging Room: Van Horne A/B Speaker 5 of 6 Louis Coussement, University Ghent, Belgium Short Talk: The Aging Genome: CpG Depletion throughout Human Evolution
Wednesday, March 20 \| 5:00PM - 7:00PM Metabolic Diseases and Aging Room: Van Horne A/B Speaker 6 of 6 Anita Öst, Linköping University, Sweden Short Talk: Diet-Sensitive Fragmentation of Sperm tRNA
Wednesday, March 20 \| 5:00PM - 7:15PM Genome Architecture and Development This session is from 3D Genome Room: Van Horne C Speaker 1 of 7 * Jennifer E. Phillips-Cremins, University of Pennsylvania, USA
Wednesday, March 20 \| 5:00PM - 7:15PM Genome Architecture and Development This session is from 3D Genome Room: Van Horne C Speaker 2 of 7 Wei Xie, Tsinghua University, China Chromatin Reprogramming in Mammalian Gametogenesis and Early Development
Wednesday, March 20 \| 5:00PM - 7:15PM Genome Architecture and Development This session is from 3D Genome Room: Van Horne C Speaker 3 of 7 Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany Genome Architecture Mapping: Discovering 3D Genome Topology in Rare Cell Types
Wednesday, March 20 \| 5:00PM - 7:15PM Genome Architecture and Development This session is from 3D Genome Room: Van Horne C Speaker 4 of 7 X. Sunney Xie, Peking University, China Decoding the 3D Human Genome
Wednesday, March 20 \| 5:00PM - 7:15PM Genome Architecture and Development This session is from 3D Genome Room: Van Horne C Speaker 5 of 7 Sajad Hamid, University of California, San Francisco, USA Short Talk: Mapping of Nuclear Lamina-Associated Genome Organization in Developing Mouse and Human Brain
Wednesday, March 20 \| 5:00PM - 7:15PM Genome Architecture and Development This session is from 3D Genome Room: Van Horne C Speaker 6 of 7 Xiong Ji, Peking University, China Short Talk: RNAPII Condensates Connect Genome Organization and Gene Regulation
Wednesday, March 20 \| 5:00PM - 7:15PM Genome Architecture and Development This session is from 3D Genome Room: Van Horne C Speaker 7 of 7 Fulai Jin, Case Western Reserve University, USA Short Talk: Multi-Scale 3D Genome Analyses in Human Neurogenesis and Brain Tissues with Easy Hi-C
Wednesday, March 20 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Mezzanine 2 No registration fees are used to fund alcohol served at this function.
Wednesday, March 20 \| 7:30PM - 10:00PM Poster Session 3 Room: Mezzanine 2
Thursday, March 21 \| 7:00AM - 8:00AM Breakfast Room: Mezzanine 2
Thursday, March 21 \| 8:00AM - 11:15AM Epigenetic Regulation in Immunoncology and Cancer Therapeuti cs Room: Van Horne A/B Speaker 1 of 9 * Christopher Vakoc, Cold Spring Harbor Laboratory, USA
Thursday, March 21 \| 8:00AM - 11:15AM Epigenetic Regulation in Immunoncology and Cancer Therapeuti cs Room: Van Horne A/B Speaker 2 of 9 Daniel De Carvalho, University Health Network, Canada DNA Methylation, Viral Mimicry, Epigenetic Therapy
Thursday, March 21 \| 8:00AM - 11:15AM Epigenetic Regulation in Immunoncology and Cancer Therapeuti cs Room: Van Horne A/B Speaker 3 of 9 Rab K. Prinjha, GlaxoSmithKline, UK Drug Discovery and Clinical Progression or Epigenetic Therapies
Thursday, March 21 \| 8:00AM - 11:15AM Epigenetic Regulation in Immunoncology and Cancer Therapeuti cs Room: Van Horne A/B Coffee Break
Thursday, March 21 \| 8:00AM - 11:15AM Epigenetic Regulation in Immunoncology and Cancer Therapeuti cs Room: Van Horne A/B Speaker 5 of 9 Benjamin Nicholson, Merck Research Laboratories, USA Epigenetics and Immune Modulation in Cancer
Thursday, March 21 \| 8:00AM - 11:15AM Epigenetic Regulation in Immunoncology and Cancer Therapeuti cs Room: Van Horne A/B Speaker 6 of 9 Ricky W. Johnstone, Peter MacCallum Cancer Centre, Australia Epigenetic Modulation of the Immune System for Cancer Treatment
Thursday, March 21 \| 8:00AM - 11:15AM Epigenetic Regulation in Immunoncology and Cancer Therapeuti cs Room: Van Horne A/B Speaker 7 of 9 Alison A. Chomiak, Van Andel Research Institute, USA Short Talk: Polycomb Signaling as a Therapeutic Axis for Enhancing Epigenetic Therapy in Colorectal Cancer
Thursday, March 21 \| 8:00AM - 11:15AM Epigenetic Regulation in Immunoncology and Cancer Therapeuti cs Room: Van Horne A/B Speaker 8 of 9 Colum P. Walsh, University of Ulster, UK Short Talk: UHRF1 Is Required to Suppress Viral Mimicry through Both DNA Methylation-Dependent and -Independent Mechanisms
Thursday, March 21 \| 8:00AM - 11:15AM Epigenetic Regulation in Immunoncology and Cancer Therapeuti cs Room: Van Horne A/B Speaker 9 of 9 Andrew Morton, Case Western Reserve University, USA Short Talk: Lineage-Specific Enhancers Are Co-Opted on Focal Oncogenic Amplifications in Solid Tumors
Thursday, March 21 \| 8:00AM - 11:00AM Computational Analysis of 3D Genome This session is from 3D Genome Room: Van Horne C Speaker 1 of 9 * Bas van Steensel, Netherlands Cancer Institute, Netherlands
Thursday, March 21 \| 8:00AM - 11:00AM Computational Analysis of 3D Genome This session is from 3D Genome Room: Van Horne C Speaker 2 of 9 David Hawkins, University of Washington, USA Short Talk: Epigenome Annotation and Three-Dimensional Genome Architecture Reveal Candidate Silencer Elements for the Human and Mouse Genomes
Thursday, March 21 \| 8:00AM - 11:00AM Computational Analysis of 3D Genome This session is from 3D Genome Room: Van Horne C Speaker 3 of 9 Frank Alber, University California, Los Angeles, USA Computational Modeling of 3D Genome
Thursday, March 21 \| 8:00AM - 11:00AM Computational Analysis of 3D Genome This session is from 3D Genome Room: Van Horne C Speaker 4 of 9 Jill E. Moore, University of Massachusetts Medical School, USA Short Talk: Evaluating Computational Methods for Predicting Enhancer-Gene Interactions
Thursday, March 21 \| 8:00AM - 11:00AM Computational Analysis of 3D Genome This session is from 3D Genome Room: Van Horne C Coffee Break
Thursday, March 21 \| 8:00AM - 11:00AM Computational Analysis of 3D Genome This session is from 3D Genome Room: Van Horne C Speaker 6 of 9 Mario Nicodemi, Universita' di Napoli Federico II, Italy Polymer Physics Predicts the Effects of Structural Variants on Chromatin Architecture
Thursday, March 21 \| 8:00AM - 11:00AM Computational Analysis of 3D Genome This session is from 3D Genome Room: Van Horne C Speaker 7 of 9 Ferhat Ay, La Jolla Institute, USA Short Talk: FitHiChIP: Identification of Chromatin Loops from HiChIP/PLAC-Seq Data
Thursday, March 21 \| 8:00AM - 11:00AM Computational Analysis of 3D Genome This session is from 3D Genome Room: Van Horne C Speaker 8 of 9 Kathleen Keough, Gladstone Institutes, University of California, San Francisco, USA Short Talk: A Role for Enhancer Hijacking in the Emergence of Human Accelerated Regions
Thursday, March 21 \| 8:00AM - 11:00AM Computational Analysis of 3D Genome This session is from 3D Genome Room: Van Horne C Speaker 9 of 9 R. Babak Faryabi, University of Pennsylvania, USA Short Talk: Notch-Instructed 3D Cancer Genome
Thursday, March 21 \| 11:15AM - 5:00PM On Own for Lunch
Thursday, March 21 \| 11:30AM - 12:30PM Roundtable Discussion: Careers in Industry (Joint) Room: Conservatory
Thursday, March 21 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Thursday, March 21 \| 5:00PM - 7:00PM 3D Genome and Disease (Joint) Room: Van Horne A/B Speaker 1 of 7 * Mark A. Dawson, Peter MacCallum Cancer Centre, Australia
Thursday, March 21 \| 5:00PM - 7:00PM 3D Genome and Disease (Joint) Room: Van Horne A/B Speaker 2 of 7 Joseph R. Ecker, The Salk Institute for Biological Studies, USA
Thursday, March 21 \| 5:00PM - 7:00PM 3D Genome and Disease (Joint) Room: Van Horne A/B Speaker 3 of 7 Xiaowei Zhuang, Harvard University, USA Single-Cell Transcriptome and Chromosome Imaging
Thursday, March 21 \| 5:00PM - 7:00PM 3D Genome and Disease (Joint) Room: Van Horne A/B Speaker 4 of 7 Bradley E. Bernstein, Massachusetts General Hospital, USA Epigenetic Plasticity and Selection in Tumorigenesis
Thursday, March 21 \| 5:00PM - 7:00PM 3D Genome and Disease (Joint) Room: Van Horne A/B Speaker 5 of 7 Anjana Rao, La Jolla Institute for Allergy and Immunology, USA TET Loss-of-Function and Oncogenesis
Thursday, March 21 \| 5:00PM - 7:00PM 3D Genome and Disease (Joint) Room: Van Horne A/B Speaker 6 of 7 Zuzana Tothova, Dana-Farber Cancer Institute, USA Short Talk: Chromatin Architecture in Leukemia through the Lens of Cohesin Complex Mutations
Thursday, March 21 \| 5:00PM - 7:00PM 3D Genome and Disease (Joint) Room: Van Horne A/B Speaker 7 of 7 Jesse Dixon, The Salk Institute for Biological Studies, USA Short Talk: Identification of Recurrent TAD Fusion Events as a Result of Structural Variation in Cancer Genomes
Thursday, March 21 \| 7:00PM - 7:15PM Meeting Wrap-Up: Outcomes and Future Directions (Joint) Room: Van Horne A/B Speaker 1 of 2 Anne Schaefer, Mount Sinai School of Medicine, USA
Thursday, March 21 \| 7:00PM - 7:15PM Meeting Wrap-Up: Outcomes and Future Directions (Joint) Room: Van Horne A/B Speaker 2 of 2 Joseph R. Ecker, The Salk Institute for Biological Studies, USA
Thursday, March 21 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Mezzanine 2 No registration fees are used to fund alcohol served at this function.
Thursday, March 21 \| 8:00PM - 11:00PM Entertainment Room: Mezzanine 2 Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, March 21 \| 8:00PM - 11:00PM Cash Bar Room: Mezzanine 2
Friday, March 22 \| 10:24AM - 10:24AM Departure *Session Chair.