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Web Desc
Noncoding RNAs: Mechanism, Function and Therapies
Organizer(s): Howard Y. Chang, Frank W. Rigo and Lynne E. Maquat
Date: January 12 - 16, 2020
Location: Fairmont Chateau Whistler, Whistler, BC, Canada
Sponsored by Ionis Pharmaceuticals, Inc. and Moderna
Summary of Meeting:
A revolution is sweeping the RNA world. The human genome contains over 60,000 long noncoding RNA genes, three times the number of protein coding genes. Many important questions are outstanding, including physiologic functions of regulatory RNAs, their molecular mechanisms, and therapeutic potential. This conference will bring together leaders in RNA biology, technology, and medicine to present the latest findings in these respective areas. We anticipate that this conference will provide an integrated view of the cutting edge of this rapidly advancing scientific area and create many opportunities for synergy and cross fertilization.
Scholarship Deadline: September 24 2019
Discounted Abstract Deadline: September 24 2019
Abstract Deadline: October 10 2019
Discounted Registration Deadline: November 12 2019
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Ionis Pharmaceuticals, Inc.Moderna
We gratefully acknowledge additional support from these exhibitors at this conference:
Eclipse Bioinnovations, Inc.
We gratefully acknowledge additional support for this conference from:
Arraystar Inc.Zymo Research Corporation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Accent Therapeutics

Arrakis Therapeutics
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 12 | 4:00PM - 8:00PM
Arrival and Registration
Room: MacDonald Foyer


Sunday, January 12 | 6:00PM - 8:00PM
Welcome Mixer
Room: MacDonald Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: MacDonald DEF


Monday, January 13 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: MacDonald ABC

Speaker 1 of 3
* Howard Y. Chang, Stanford University, USA

Monday, January 13 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: MacDonald ABC

Speaker 2 of 3
* Lynne E. Maquat, University of Rochester Medical Center, USA

Monday, January 13 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: MacDonald ABC

Speaker 3 of 3
Joan A. Steitz, Yale University, USA
Viral Noncoding RNAs: Approaching Answers

Monday, January 13 | 9:00AM - 11:30AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 1 of 7
* Joshua T. Mendell, University of Texas Southwestern Medical Center, USA

Monday, January 13 | 9:00AM - 11:30AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 2 of 7
Lynne E. Maquat, University of Rochester Medical Center, USA
3’UTR-Mediated Post-transcriptional Effects on Human Gene Expression via Staufen and SINEs

Monday, January 13 | 9:00AM - 11:30AM
LncRNA Mechanisms
Room: MacDonald ABC


Coffee Break

Monday, January 13 | 9:00AM - 11:30AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 4 of 7
Montserrat Anguera, University of Pennsylvania, USA
X-Chromosome Inactivation Maintenance in Immune Cells

Monday, January 13 | 9:00AM - 11:30AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 5 of 7
Elsa R. Flores, Moffitt Cancer Center, USA
Pan-Cancer Analysis Reveals Alternate Mechanisms for AKT Activation through TAp63 Regulated Oncogenic lncRNAs (TROLLs)

Monday, January 13 | 9:00AM - 11:30AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 6 of 7
Nicolas Jaé, Goethe-University Frankfurt, Germany
Short Talk: Control of Vessel Permeability by the Splicing-Regulatory lncRNA NTRAS

Monday, January 13 | 9:00AM - 11:30AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 7 of 7
Amanda J. Whipple, Harvard University, USA
Short Talk: Imprinted Maternally-Expressed MicroRNAs Antagonize Paternally-Driven Gene Programs in Neurons

Monday, January 13 | 11:30AM - 5:00PM
On Own for Lunch


Monday, January 13 | 11:30AM - 1:00PM
Poster Setup
Room: MacDonald DEF


Monday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: MacDonald DEF


Monday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: MacDonald Foyer


Monday, January 13 | 5:00PM - 7:00PM
Regulatory RNA Physiologic Functions
Room: MacDonald ABC

Speaker 1 of 6
* Lynne E. Maquat, University of Rochester Medical Center, USA

Monday, January 13 | 5:00PM - 7:00PM
Regulatory RNA Physiologic Functions
Room: MacDonald ABC

Speaker 2 of 6
Alena Shkumatava, Institut Curie-Centre de Recherche, France
LncRNA in Vertebrate Development

Monday, January 13 | 5:00PM - 7:00PM
Regulatory RNA Physiologic Functions
Room: MacDonald ABC

Speaker 3 of 6
Upasna Sharma, University of California, Santa Cruz, USA
Intergenerational Epigenetic Inheritance by Sperm Small RNAs

Monday, January 13 | 5:00PM - 7:00PM
Regulatory RNA Physiologic Functions
Room: MacDonald ABC

Speaker 4 of 6
Tamer Sallam, University of California, Los Angeles, USA
LncRNA in Cardiometabolic Disease

Monday, January 13 | 5:00PM - 7:00PM
Regulatory RNA Physiologic Functions
Room: MacDonald ABC

Speaker 5 of 6
Sathya Puthanveettil, The Scripps Research Institute, USA
Short Talk: Activity Dependent Synaptic Targeting of Intronic lncRNA for Long-Term Memory Storage

Monday, January 13 | 5:00PM - 7:00PM
Regulatory RNA Physiologic Functions
Room: MacDonald ABC

Speaker 6 of 6
Daniel Kim, University of California, Santa Cruz, USA
Short Talk: Noncoding RNA Landscape of Mutant KRAS-Driven Cellular Transformation

Monday, January 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: MacDonald DEF
No registration fees are used to fund alcohol served at this function.

Monday, January 13 | 7:30PM - 10:00PM
Poster Session 1
Room: MacDonald DEF


Tuesday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: MacDonald DEF


Tuesday, January 14 | 8:00AM - 11:15AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 1 of 9
* Karissa Y. Sanbonmatsu, Los Alamos National Laboratory, USA

Tuesday, January 14 | 8:00AM - 11:15AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 2 of 9
Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs

Tuesday, January 14 | 8:00AM - 11:15AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 3 of 9
Susan B. Carpenter, University of California, Santa Cruz, USA
Characterization of the Conserved lncRNA, GAPLINC, and Its Role in Endotoxic Shock

Tuesday, January 14 | 8:00AM - 11:15AM
LncRNA Mechanisms
Room: MacDonald ABC


Coffee Break

Tuesday, January 14 | 8:00AM - 11:15AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 5 of 9
Joshua T. Mendell, University of Texas Southwestern Medical Center, USA
Regulation and Function of Mammalian Noncoding RNAs

Tuesday, January 14 | 8:00AM - 11:15AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 6 of 9
John L. Rinn, University of Colorado Boulder, USA
Differential Contribution of Steady-State RNA and Active Transcription in Chromatin Organization

Tuesday, January 14 | 8:00AM - 11:15AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 7 of 9
Nadya Dimitrova, Yale University, USA
Short Talk: Investigation of the Mechanisms of lncRNAs in Tumorigenesis

Tuesday, January 14 | 8:00AM - 11:15AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 8 of 9
Adam Schmitt, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Cancers Escape Tumor Suppression through Loss of the Long Noncoding RNA Dino

Tuesday, January 14 | 8:00AM - 11:15AM
LncRNA Mechanisms
Room: MacDonald ABC

Speaker 9 of 9
Prasanth V. Kannanganattu, University of Illinois, USA
Short Talk: A Family of Nucleolus-Enriched ncRNAs Regulate rDNA Expression by Coating the NOR-Containing Autosomes in a Monoallelic Fashion

Tuesday, January 14 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, January 14 | 11:15AM - 1:00PM
Poster Setup
Room: MacDonald DEF


Tuesday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: MacDonald DEF


Tuesday, January 14 | 3:00PM - 4:30PM
Workshop
Room: MacDonald ABC

Speaker 1 of 7
* Robert Spitale, University of California, Irvine, USA

Tuesday, January 14 | 3:00PM - 4:30PM
Workshop
Room: MacDonald ABC

Speaker 2 of 7
Chen Davidovich, Monash University, Australia
RNA Mediates Context-Specific Regulation of Gene Repression through Interactions with the Regulatory Centre of the Histone Methyltransferase PRC2

Tuesday, January 14 | 3:00PM - 4:30PM
Workshop
Room: MacDonald ABC

Speaker 3 of 7
Simon A. Hardwick, Weill Cornell Medicine, USA
High Resolution Analysis of Long Non-Coding RNA Isoforms in Mouse Cortex

Tuesday, January 14 | 3:00PM - 4:30PM
Workshop
Room: MacDonald ABC

Speaker 4 of 7
Tim Vierbuchen, University of Massachusetts Medical School, USA
Regulation of Type I Interferon Responses in Human Phagocytes by the Long Non-Coding RNAs LUCAT1 and lncRNA-CMPK2

Tuesday, January 14 | 3:00PM - 4:30PM
Workshop
Room: MacDonald ABC

Speaker 5 of 7
Ryan Alexander Flynn, Stanford University, USA
Mammalian Small RNAs Are Modified at Discrete Guanosine Residues with N-Glycans

Tuesday, January 14 | 3:00PM - 4:30PM
Workshop
Room: MacDonald ABC

Speaker 6 of 7
Tasha Alease Morrison, National Institutes of Health, USA
Identification of a Long Noncoding RNA within an NK-Specific Super-Enhancer Uncovers Critical Role Ugcg Plays in NK Cells

Tuesday, January 14 | 3:00PM - 4:30PM
Workshop
Room: MacDonald ABC

Speaker 7 of 7
Christiane Olivero, Yale University, USA
p53 Activates the lncRNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis

Tuesday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: MacDonald Foyer


Tuesday, January 14 | 5:00PM - 7:15PM
RNA Structure and Function
Room: MacDonald ABC

Speaker 1 of 7
* Christine Mayr, Memorial Sloan Kettering Cancer Center, USA

Tuesday, January 14 | 5:00PM - 7:15PM
RNA Structure and Function
Room: MacDonald ABC

Speaker 2 of 7
Yue Wan, Genome Institute of Singapore, Singapore
Studying RNA Structures Using Direct RNA Sequencing on Nanopores

Tuesday, January 14 | 5:00PM - 7:15PM
RNA Structure and Function
Room: MacDonald ABC

Speaker 3 of 7
Karissa Y. Sanbonmatsu, Los Alamos National Laboratory, USA
Zinc-Finger Protein CNBP Alters the 3-D Structure of lncRNA Braveheart in Solution

Tuesday, January 14 | 5:00PM - 7:15PM
RNA Structure and Function
Room: MacDonald ABC

Speaker 4 of 7
Robert Spitale, University of California, Irvine, USA
Emergent Chemical Methods for Probing RNA Structure Inside Living Cells

Tuesday, January 14 | 5:00PM - 7:15PM
RNA Structure and Function
Room: MacDonald ABC

Speaker 5 of 7
Allison Marly Porman, University of Colorado Anschutz Medical Campus, USA
Short Talk: N6-Methyladenosine and YTHDC1 Regulate Long Noncoding RNA HOTAIR Function in Breast Cancer

Tuesday, January 14 | 5:00PM - 7:15PM
RNA Structure and Function
Room: MacDonald ABC

Speaker 6 of 7
Hala Abou Assi, Duke University, USA
Short Talk: Investigating the Impact of Epitranscriptomic Modifications on RNA Structural Dynamics

Tuesday, January 14 | 5:00PM - 7:15PM
RNA Structure and Function
Room: MacDonald ABC

Speaker 7 of 7
Chase Weidmann, University of North Carolina at Chapel Hill, USA
Short Talk: RNP-MaP: RNA-Protein Interaction Networks in Living Cells

Tuesday, January 14 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: MacDonald DEF
No registration fees are used to fund alcohol served at this function.

Tuesday, January 14 | 7:30PM - 10:00PM
Poster Session 2
Room: MacDonald DEF


Wednesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: MacDonald DEF


Wednesday, January 15 | 8:00AM - 11:00AM
RNA Technologies
Room: MacDonald ABC

Speaker 1 of 8
* Sara R. Cherry, University of Pennsylvania, USA

Wednesday, January 15 | 8:00AM - 11:00AM
RNA Technologies
Room: MacDonald ABC

Speaker 2 of 8
Gene W. Yeo, University of California, San Diego, USA
RNP Discovery and Manipulation

Wednesday, January 15 | 8:00AM - 11:00AM
RNA Technologies
Room: MacDonald ABC

Speaker 3 of 8
J. Mauro Calabrese, University of North Carolina at Chapel Hill, USA
Studying lncRNAs through K-Mer Based Methods of Sequence Comparison

Wednesday, January 15 | 8:00AM - 11:00AM
RNA Technologies
Room: MacDonald ABC


Coffee Break

Wednesday, January 15 | 8:00AM - 11:00AM
RNA Technologies
Room: MacDonald ABC

Speaker 5 of 8
Mitchell Guttman, California Institute of Technology, USA
A Widespread Role for RNA in Demarcating Distinct 3D Spatial Territories within the Nucleus

Wednesday, January 15 | 8:00AM - 11:00AM
RNA Technologies
Room: MacDonald ABC

Speaker 6 of 8
Mitchell R. O'Connell, University of Rochester Medical Center, USA
Programmable RNA-Targeting by CRISPR-Cas Enzymes

Wednesday, January 15 | 8:00AM - 11:00AM
RNA Technologies
Room: MacDonald ABC

Speaker 7 of 8
Hyaeyeong Kim, Weill Cornell Medicine, USA
Short Talk: Chemogenetic Control of Phase Separations in Live Cells Templated by Small Molecule-Regulated RNA Dimerization

Wednesday, January 15 | 8:00AM - 11:00AM
RNA Technologies
Room: MacDonald ABC

Speaker 8 of 8
Kengo Sato, Keio University, Japan
Short Talk: A Max-Margin Training of RNA Secondary Structure Prediction Integrated with the Thermodynamic Model

Wednesday, January 15 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: MacDonald Foyer


Wednesday, January 15 | 5:00PM - 7:00PM
Circular RNAs and RNA Modification
Room: MacDonald ABC

Speaker 1 of 6
* Nadya Dimitrova, Yale University, USA

Wednesday, January 15 | 5:00PM - 7:00PM
Circular RNAs and RNA Modification
Room: MacDonald ABC

Speaker 2 of 6
Chuan He, University of Chicago, USA
RNA Methylation in Gene Expression Regulation

Wednesday, January 15 | 5:00PM - 7:00PM
Circular RNAs and RNA Modification
Room: MacDonald ABC

Speaker 3 of 6
Dimitrios Papaioannou, Ohio State University, USA
Short Talk: CircPCMTD1: A Protein-Coding Circular RNA That Regulates DNA Synthesis in Leukemia

Wednesday, January 15 | 5:00PM - 7:00PM
Circular RNAs and RNA Modification
Room: MacDonald ABC

Speaker 4 of 6
Rui Zhou, Johns Hopkins University School of Medicine, USA
Short Talk: Function and Regulation of the Circular RNA Edis in Innate Immunity and Neurodevelopment

Wednesday, January 15 | 5:00PM - 7:00PM
Circular RNAs and RNA Modification
Room: MacDonald ABC

Speaker 5 of 6
Christopher Lee Holley, Duke University, USA
Short Talk: Modification of Messenger RNA by 2'-O-Methylation Regulates Gene Expression

Wednesday, January 15 | 5:00PM - 7:00PM
Circular RNAs and RNA Modification
Room: MacDonald ABC

Speaker 6 of 6
Tristan R. Grams, University of Florida, USA
Short Talk: Targeting the Viral lncRNA LAT of Herpes Simplex Virus 1 Reduces Reactivation in vivo

Wednesday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: MacDonald DEF
No registration fees are used to fund alcohol served at this function.

Thursday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: MacDonald DEF


Thursday, January 16 | 8:00AM - 11:00AM
RNA Therapeutics
Room: MacDonald ABC

Speaker 1 of 8
* Frank Rigo, Ionis Pharmaceuticals, USA

Thursday, January 16 | 8:00AM - 11:00AM
RNA Therapeutics
Room: MacDonald ABC

Speaker 2 of 8
Sven Diederichs, University of Freiburg, Germany
RNA-Dependent Proteins and Non-Coding RNAs in Cancer

Thursday, January 16 | 8:00AM - 11:00AM
RNA Therapeutics
Room: MacDonald ABC

Speaker 3 of 8
Sara R. Cherry, University of Pennsylvania, USA
Defining the Landscape of Antiviral Long Noncoding RNAs

Thursday, January 16 | 8:00AM - 11:00AM
RNA Therapeutics
Room: MacDonald ABC


Coffee Break

Thursday, January 16 | 8:00AM - 11:00AM
RNA Therapeutics
Room: MacDonald ABC

Speaker 5 of 8
Scott A. Ribich, Accent Therapeutics, USA
The RNA Editor ADAR1 is a Therapeutic Target in Cancers with Intrinsic Elevated Type I Interferon Signaling

Thursday, January 16 | 8:00AM - 11:00AM
RNA Therapeutics
Room: MacDonald ABC

Speaker 6 of 8
James Barsoum, Arrakis Therapeutics, USA
Targeting RNA Structures with Drug-Like Small Molecules

Thursday, January 16 | 8:00AM - 11:00AM
RNA Therapeutics
Room: MacDonald ABC

Speaker 7 of 8
Timothy Bredy, University of Queensland, Australia
Short Talk: RNA Modifications and Experience-Dependent Plasticity

Thursday, January 16 | 8:00AM - 11:00AM
RNA Therapeutics
Room: MacDonald ABC

Speaker 8 of 8
Chun-Kan Chen, Stanford University School of Medicine, USA
Short Talk: Structured Elements Drive Circular RNA Translation and Expand the Human Proteome

Thursday, January 16 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: MacDonald Foyer


Thursday, January 16 | 5:00PM - 6:45PM
Regulatory RNA in Development
Room: MacDonald ABC

Speaker 1 of 5
* Alena Shkumatava, Institut Curie-Centre de Recherche, France

Thursday, January 16 | 5:00PM - 6:45PM
Regulatory RNA in Development
Room: MacDonald ABC

Speaker 2 of 5
Christine Mayr, Memorial Sloan Kettering Cancer Center, USA
Enhancer-Mediated Control of 3'UTR Ratios Regulates PTEN Phosphatase Activity


Thursday, January 16 | 5:00PM - 6:45PM
Regulatory RNA in Development
Room: MacDonald ABC

Speaker 3 of 5
Jason Shepherd, University of Utah, USA
Virus-Like Intercellular RNA Transfer in the Nervous System

Thursday, January 16 | 5:00PM - 6:45PM
Regulatory RNA in Development
Room: MacDonald ABC

Speaker 4 of 5
Kevin G. Nyberg, Northwestern University, USA
Short Talk: Investigation of the Role of a Pair of Divergent lncRNAs in Drosophila Eggshell Development

Thursday, January 16 | 5:00PM - 6:45PM
Regulatory RNA in Development
Room: MacDonald ABC

Speaker 5 of 5
Haruna Yamashiro, University of Tokyo, Japan
Short Talk: Molecular Mechanism underlying Inter-Organelle Translocation of piRNA Precursor

Thursday, January 16 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: MacDonald ABC

Speaker 1 of 1
Frank Rigo, Ionis Pharmaceuticals, USA

Thursday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: MacDonald DEF
No registration fees are used to fund alcohol served at this function.

Thursday, January 16 | 8:00PM - 11:00PM
Entertainment
Room: MacDonald DEF
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Friday, January 17 | 10:24AM - 10:24AM
Departure


*Session Chair.