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Tuberculosis: Science Aimed at Ending the Epidemic (2021EK10)

Web Desc
Tuberculosis: Immunity and Immune Evasion Organizer(s): Joel Ernst, Jennifer Philips and Daniel L. Barber Date: January 16 - 20, 2020 Location: Eldorado Hotel & Spa, Santa Fe, NM, USA Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation Summary of Meeting: Tuberculosis remains the most common fatal infectious disease worldwide due to the absence of a sufficiently effective vaccine. Two critical barriers to the development of an effective TB vaccine are the incomplete understanding of the mechanisms of protective immunity to TB, and of the mechanisms of immune evasion by M. tuberculosis. The interactions among speakers and attendees at this conference will promote collaborations between scientists with complementary expertise who work in geographically distinct institutions, including those in high TB burden regions. This conference will present new findings on mechanisms of protective immunity to M. tuberculosis, and promote dialogue between immunologists and scientists in different areas of expertise to fill gaps in knowledge. Participants will also discuss advances in TB vaccine development and vaccine immunology. Finally, this conference will cover advances in other fields of immunology and other infectious diseases characterized by pathogen persistence, which will help to inform development of effective TB vaccines. Global Health Travel Award Deadline: August 13 2019 Scholarship Deadline: September 24 2019 Discounted Abstract Deadline: September 24 2019 Abstract Deadline: October 16 2019 Discounted Registration Deadline: November 19 2019 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Allergy and Infectious Diseases (NIAID) Grant No. 1R13AI147619-01 Funding for this conference was made possible (in part) by 1R13AI147619-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Tuberculosis: Immunity and Immune Evasion

Organizer(s): Joel Ernst, Jennifer Philips and Daniel L. Barber

Date: January 16 - 20, 2020
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation

Summary of Meeting:

Tuberculosis remains the most common fatal infectious disease worldwide due to the absence of a sufficiently effective vaccine. Two critical barriers to the development of an effective TB vaccine are the incomplete understanding of the mechanisms of protective immunity to TB, and of the mechanisms of immune evasion by M. tuberculosis. The interactions among speakers and attendees at this conference will promote collaborations between scientists with complementary expertise who work in geographically distinct institutions, including those in high TB burden regions. This conference will present new findings on mechanisms of protective immunity to M. tuberculosis, and promote dialogue between immunologists and scientists in different areas of expertise to fill gaps in knowledge. Participants will also discuss advances in TB vaccine development and vaccine immunology. Finally, this conference will cover advances in other fields of immunology and other infectious diseases characterized by pathogen persistence, which will help to inform development of effective TB vaccines.

Global Health Travel Award Deadline: August 13 2019

Scholarship Deadline: September 24 2019

Discounted Abstract Deadline: September 24 2019

Abstract Deadline: October 16 2019

Discounted Registration Deadline: November 19 2019

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI147619-01
Funding for this conference was made possible (in part) by 1R13AI147619-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Thursday, January 16 \| 4:00PM - 8:00PM Arrival and Registration Room: Cava Santa Fe
Thursday, January 16 \| 6:00PM - 8:00PM Welcome Mixer Room: Cava Santa Fe No registration fees are used to fund alcohol served at this function.
Friday, January 17 \| 7:00AM - 8:00AM Breakfast Room: Anasazi Ballroom
Friday, January 17 \| 7:30AM - 8:00AM Poster Setup Room: Anasazi Ballroom
Friday, January 17 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Eldorado Grand Ballroom Speaker 2 of 2 Eric Goosby, University of California, San Francisco / United Nations, USA Global Solutions to Elimination of Tuberculosis: The Roles of Immunology and Vaccines
Friday, January 17 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Eldorado Grand Ballroom Speaker 1 of 2 * Joel D. Ernst, University of California, San Francisco, USA
Friday, January 17 \| 8:00AM - 7:00PM Poster Viewing Room: Anasazi Ballroom
Friday, January 17 \| 9:00AM - 11:00AM TB Vaccines and Vaccine Immunology Room: Eldorado Grand Ballroom Speaker 5 of 5 Ann M. Ginsberg, BMGF, USA TB Vaccine Human Efficacy Trials: What Have We Learned? Where Are We Headed?
Friday, January 17 \| 9:00AM - 11:00AM TB Vaccines and Vaccine Immunology Room: Eldorado Grand Ballroom Speaker 4 of 5 Thomas J. Scriba, University of Cape Town, South Africa Immune Responses to Diverse TB Vaccines in Humans
Friday, January 17 \| 9:00AM - 11:00AM TB Vaccines and Vaccine Immunology Room: Eldorado Grand Ballroom Coffee Break
Friday, January 17 \| 9:00AM - 11:00AM TB Vaccines and Vaccine Immunology Room: Eldorado Grand Ballroom Speaker 2 of 5 Patricia A. Darrah, NIAID, National Institutes of Health, USA Evaluating Mechanisms of Protection after Intravenous BCG Immunization in Nonhuman Primates
Friday, January 17 \| 9:00AM - 11:00AM TB Vaccines and Vaccine Immunology Room: Eldorado Grand Ballroom Speaker 1 of 5 * Joel D. Ernst, University of California, San Francisco, USA
Friday, January 17 \| 11:00AM - 12:30PM Lunch Room: Anasazi Ballroom
Friday, January 17 \| 12:00PM - 2:30PM Poster Session 1 Room: Anasazi Ballroom
Friday, January 17 \| 2:30PM - 4:30PM Workshop 1: Moving Beyond Th1 Immunity in TB Room: Eldorado Grand Ballroom Speaker 8 of 9 Michael C. Kiritsy, University of Massachusetts Medical School, USA Dissecting Host Innate Immunity to Tuberculosis Using Engineered and Natural Genetic Variation
Friday, January 17 \| 2:30PM - 4:30PM Workshop 1: Moving Beyond Th1 Immunity in TB Room: Eldorado Grand Ballroom Speaker 7 of 9 David M. Lewinsohn, Oregon Health & Science University, USA Presentation of Mtb-Derived Antigens to MR1T Cells: A Unique Role for Endosomal Trafficking, and an Inhibitory Role for the MR1B Splice Variant
Friday, January 17 \| 2:30PM - 4:30PM Workshop 1: Moving Beyond Th1 Immunity in TB Room: Eldorado Grand Ballroom Speaker 6 of 9 Shunsuke Sakai, NIAID, National Institutes of Health, USA Immunoregulatory and Host-Protective Functions of MAIT Cells during Mycobacterium tuberculosis Infection
Friday, January 17 \| 2:30PM - 4:30PM Workshop 1: Moving Beyond Th1 Immunity in TB Room: Eldorado Grand Ballroom Speaker 5 of 9 Paula Ruibal, Leiden University Medical Center, Netherlands Identification of Novel HLA-E Binding Mtb-Derived Peptides as Potential Vaccine Candidates
Friday, January 17 \| 2:30PM - 4:30PM Workshop 1: Moving Beyond Th1 Immunity in TB Room: Eldorado Grand Ballroom Speaker 4 of 9 Rachel L. Tanner, University of Oxford, UK Characterising the BCG-Induced Humoral Immune Response to Inform the Design of Improved TB Vaccines
Friday, January 17 \| 2:30PM - 4:30PM Workshop 1: Moving Beyond Th1 Immunity in TB Room: Eldorado Grand Ballroom Speaker 3 of 9 Hao Li, China Agricultural University, China Isolation and Functional Characterization of Fully Human Protective Monoclonal Antibodies Directed against the Surface of Mycobacterium tuberculosis
Friday, January 17 \| 2:30PM - 4:30PM Workshop 1: Moving Beyond Th1 Immunity in TB Room: Eldorado Grand Ballroom Speaker 2 of 9 Shi-Hsia Hwa, Africa Health Research Institute, South Africa Human Serum and Monoclonal Antibodies Can Inhibit Intracellular Mycobacterium Tuberculosis Growth and Promote Phagocyte Survival
Friday, January 17 \| 2:30PM - 4:30PM Workshop 1: Moving Beyond Th1 Immunity in TB Room: Eldorado Grand Ballroom Speaker 1 of 9 * Andrew Olive, Michigan State University, USA
Friday, January 17 \| 2:30PM - 4:30PM Workshop 1: Moving Beyond Th1 Immunity in TB Room: Eldorado Grand Ballroom Speaker 9 of 9 Daniel F. Hoft, St. Louis University, USA A Human BCG Challenge Model to Assess TB Vaccines and Identify Immune Biomarkers
Friday, January 17 \| 4:30PM - 5:00PM Coffee Available Room: Concourse
Friday, January 17 \| 5:00PM - 7:00PM Impact of Host and Pathogen Diversity Room: Eldorado Grand Ballroom Speaker 1 of 5 * Thuong T. T. Nguyen, Oxford University Clinical Research Unit, Vietnam
Friday, January 17 \| 5:00PM - 7:00PM Impact of Host and Pathogen Diversity Room: Eldorado Grand Ballroom Speaker 2 of 5 Chetan Seshadri, University of Washington, USA IFN-?-Independent Immune Markers of Mycobacterium tuberculosis Exposure
Friday, January 17 \| 5:00PM - 7:00PM Impact of Host and Pathogen Diversity Room: Eldorado Grand Ballroom Speaker 3 of 5 Sara Suliman, Brigham and Women's Hospital, USA Human Genetic and Transcriptional Correlates of TB Progression
Friday, January 17 \| 5:00PM - 7:00PM Impact of Host and Pathogen Diversity Room: Eldorado Grand Ballroom Speaker 4 of 5 Shabaana A. Khader, Washington University School of Medicine, USA Role of Innate Lymphoid Cells in Tuberculosis
Friday, January 17 \| 5:00PM - 7:00PM Impact of Host and Pathogen Diversity Room: Eldorado Grand Ballroom Speaker 5 of 5 Sarah M. Fortune, Harvard TH Chan School of Public Health, USA Single Cell RNAseq Reveals Novel Correlates of TB Granuloma Fate
Saturday, January 18 \| 7:00AM - 8:00AM Breakfast Room: Anasazi Ballroom
Saturday, January 18 \| 8:00AM - 11:00AM Mechanisms of T Cell Protection Room: Eldorado Grand Ballroom Speaker 1 of 8 * Cheryl L. Day, Emory University, USA
Saturday, January 18 \| 8:00AM - 11:00AM Mechanisms of T Cell Protection Room: Eldorado Grand Ballroom Speaker 2 of 8 Marc K. Jenkins, University of Minnesota Medical School, USA CD4+ T Cell-Based Control of a Phagosomal Pathogen
Saturday, January 18 \| 8:00AM - 11:00AM Mechanisms of T Cell Protection Room: Eldorado Grand Ballroom Speaker 3 of 8 Cecilia S. Lindestam Arlehamn, La Jolla Institute for Allergy and Immunology, USA T Cell Transcriptomics Reveal Immune Signatures of Tuberculosis
Saturday, January 18 \| 8:00AM - 11:00AM Mechanisms of T Cell Protection Room: Eldorado Grand Ballroom Coffee Break
Saturday, January 18 \| 8:00AM - 11:00AM Mechanisms of T Cell Protection Room: Eldorado Grand Ballroom Speaker 5 of 8 Daniel L. Barber, NIAID, National Institutes of Health, USA Protective CD4 T Cell Responses to M. tuberculosis Infection
Saturday, January 18 \| 8:00AM - 11:00AM Mechanisms of T Cell Protection Room: Eldorado Grand Ballroom Speaker 6 of 8 Paul Ogongo, University of California, San Francisco, USA Compartmentalization of M. tuberculosis-Specific Human T-Cells in the Lung
Saturday, January 18 \| 8:00AM - 11:00AM Mechanisms of T Cell Protection Room: Eldorado Grand Ballroom Speaker 7 of 8 Munyaradzi Nyasha Musvosvi, University of Cape Town, South Africa Short Talk: Mycobacteria-Specific T Cell Receptor Clonotypes Associated with Mycobacterium tuberculosis Infection Outcome
Saturday, January 18 \| 8:00AM - 11:00AM Mechanisms of T Cell Protection Room: Eldorado Grand Ballroom Speaker 8 of 8 Christine Nelson, NIAID, National Institutes of Health, USA Short Talk: CD226 and CD28 Have Opposing Roles in the Generation of Lung-Homing CD4 T Cells during M. tuberculosis Infection
Saturday, January 18 \| 11:00AM - 5:00PM On Own for Lunch
Saturday, January 18 \| 11:00AM - 1:00PM Poster Setup Room: Anasazi Ballroom
Saturday, January 18 \| 1:00PM - 10:00PM Poster Viewing Room: Anasazi Ballroom
Saturday, January 18 \| 3:00PM - 4:30PM Workshop 2: Impact of Coinfections and Comorbidities on TB I mmunity Room: Eldorado Grand Ballroom Speaker 1 of 7 * Blanca I. Restrepo, University of Texas HSC Houston, Brownsville Campus, USA
Saturday, January 18 \| 3:00PM - 4:30PM Workshop 2: Impact of Coinfections and Comorbidities on TB I mmunity Room: Eldorado Grand Ballroom Speaker 2 of 7 Taryn A. McLaughlin, Emory University, USA CD4 T Cells in Mycobacterium tuberculosis and Schistosoma Mansoni Co-Infected Individuals Maintain Functional TH1 Responses
Saturday, January 18 \| 3:00PM - 4:30PM Workshop 2: Impact of Coinfections and Comorbidities on TB I mmunity Room: Eldorado Grand Ballroom Speaker 4 of 7 Mohau Steven Makatsa, University of Cape Town, South Africa Characterization of Mtb-Specific Th22 Cells in HIV and TB Co-Infection
Saturday, January 18 \| 3:00PM - 4:30PM Workshop 2: Impact of Coinfections and Comorbidities on TB I mmunity Room: Eldorado Grand Ballroom Speaker 3 of 7 Deepak Tripathi, University of Texas Health Science Center at Tyler, USA IL-22 Produced by Type 3 Innate Lymphoid Cells (ILC3s) Reduces the Mortality of Type 2 Diabetes Mellitus (T2DM) Mice Infected with Mycobacterium tuberculosis
Saturday, January 18 \| 3:00PM - 4:30PM Workshop 2: Impact of Coinfections and Comorbidities on TB I mmunity Room: Eldorado Grand Ballroom Speaker 6 of 7 Charles A. Scanga, University of Pittsburgh School of Medicine, USA Vaccination with Intravenous BCG Confers Remarkable Protection from Tuberculosis in SIV+ Macaques
Saturday, January 18 \| 3:00PM - 4:30PM Workshop 2: Impact of Coinfections and Comorbidities on TB I mmunity Room: Eldorado Grand Ballroom Speaker 7 of 7 Robert Blomgran, Linköping University, Sweden Beneficial Effects of Helminth Antigen Exposure for the Control of Mycobacterium tuberculosis Infection in Monocytes and Macrophages, Contrasting the Effect of Chronic Helminth Infection
Saturday, January 18 \| 3:00PM - 4:30PM Workshop 2: Impact of Coinfections and Comorbidities on TB I mmunity Room: Eldorado Grand Ballroom Speaker 5 of 7 Susana Benet, Irsicaixa, Spain Impact of Siglec-1 Variant on Disseminated Tuberculosis during HIV-1 Co-Infection
Saturday, January 18 \| 4:30PM - 5:00PM Coffee Available Room: Concourse
Saturday, January 18 \| 5:00PM - 7:15PM Immunometabolism and Host-Directed Therapies Room: Eldorado Grand Ballroom Speaker 1 of 7 * Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands
Saturday, January 18 \| 5:00PM - 7:15PM Immunometabolism and Host-Directed Therapies Room: Eldorado Grand Ballroom Speaker 2 of 7 Amit Singhal, Singapore Immunology Network, Singapore Reprograming Host Immunometabolic Circuits for Designing TB HDT
Saturday, January 18 \| 5:00PM - 7:15PM Immunometabolism and Host-Directed Therapies Room: Eldorado Grand Ballroom Speaker 3 of 7 Sarah A. Stanley, University of California, Berkeley, USA Metabolic Regulation of Macrophage Activation during Mtb Infection
Saturday, January 18 \| 5:00PM - 7:15PM Immunometabolism and Host-Directed Therapies Room: Eldorado Grand Ballroom Speaker 4 of 7 Jennifer Philips, Washington University School of Medicine, USA Targeting Host Metabolism to Treat TB
Saturday, January 18 \| 5:00PM - 7:15PM Immunometabolism and Host-Directed Therapies Room: Eldorado Grand Ballroom Speaker 5 of 7 Jeffey M. Collins, Emory University School of Medicine, USA Short Talk: Tryptophan Catabolism Reflects Disease Activity and Treatment Response in Latent Infection and Active Disease Caused by Mycobacterium tuberculosis
Saturday, January 18 \| 5:00PM - 7:15PM Immunometabolism and Host-Directed Therapies Room: Eldorado Grand Ballroom Speaker 6 of 7 Katharina Ronacher, University of Queensland, Australia Short Talk: Identification of a Putative Target for Host-Directed Therapy: A Cholesterol Receptor Regulates Interferons and Bacterial Growth during M. tuberculosis Infection
Saturday, January 18 \| 5:00PM - 7:15PM Immunometabolism and Host-Directed Therapies Room: Eldorado Grand Ballroom Speaker 7 of 7 Hua Yang, Shanghai Pulmonary Hospital, Tongji University School of Medicine, China Short Talk: Interception of Host Fatty Acid Metabolism by Mycobacteria Under Hypoxia to Suppress Anti-TB Immunity
Saturday, January 18 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Anasazi Ballroom No registration fees are used to fund alcohol served at this function.
Saturday, January 18 \| 7:30PM - 10:00PM Poster Session 2 Room: Anasazi Ballroom
Sunday, January 19 \| 7:00AM - 8:00AM Breakfast Room: Anasazi Ballroom
Sunday, January 19 \| 8:00AM - 11:15AM Lessons from Beyond TB Room: Eldorado Grand Ballroom Speaker 1 of 9 * Sarah A. Stanley, University of California, Berkeley, USA
Sunday, January 19 \| 8:00AM - 11:15AM Lessons from Beyond TB Room: Eldorado Grand Ballroom Speaker 2 of 9 Steven M. Holland, NIAID, National Institutes of Health, USA Are Infections in the Lung and Outside it the Same? Host Factors in Mycobacterial Tissue Specificity
Sunday, January 19 \| 8:00AM - 11:15AM Lessons from Beyond TB Room: Eldorado Grand Ballroom Speaker 3 of 9 Nevil J. Singh, University of Maryland, USA The Signaling Logic Regulating T Cell Responses to Persistent Antigens
Sunday, January 19 \| 8:00AM - 11:15AM Lessons from Beyond TB Room: Eldorado Grand Ballroom Coffee Break
Sunday, January 19 \| 8:00AM - 11:15AM Lessons from Beyond TB Room: Eldorado Grand Ballroom Speaker 5 of 9 David L. Sacks, NIAID, National Institutes of Health, USA Dermis Resident Macrophages are Maintained as a Replicative Niche for Leishmania in a Th1 Immune Environment
Sunday, January 19 \| 8:00AM - 11:15AM Lessons from Beyond TB Room: Eldorado Grand Ballroom Speaker 6 of 9 Haina Shin, Washington University, USA Distinct Host Restriction of HSV-1 and HSV-2 Genital Herpes
Sunday, January 19 \| 8:00AM - 11:15AM Lessons from Beyond TB Room: Eldorado Grand Ballroom Speaker 7 of 9 Lara Mittereder, Food and Drug Administration, USA Short Talk: Primed Lymphocytes That Control Intramacrophage Bacterial Replication Shift Metabolism toward Glycolysis
Sunday, January 19 \| 8:00AM - 11:15AM Lessons from Beyond TB Room: Eldorado Grand Ballroom Speaker 8 of 9 Erika J. Hughes, Duke University, USA Short Talk: Single-Cell RNA-Seq of Zebrafish Granulomas Reveals Altered Cell Composition and Inflammatory Expression Profiles Associated with Dysregulated Eicosanoid Signaling
Sunday, January 19 \| 8:00AM - 11:15AM Lessons from Beyond TB Room: Eldorado Grand Ballroom Speaker 9 of 9 Ya-Ting Wang, Washington University School of Medicine, USA Short Talk: Redefining the Role of Autophagy in Infectious Disease
Sunday, January 19 \| 11:15AM - 5:00PM On Own for Lunch
Sunday, January 19 \| 11:15AM - 1:00PM Poster Setup Room: Anasazi Ballroom
Sunday, January 19 \| 1:00PM - 10:00PM Poster Viewing Room: Anasazi Ballroom
Sunday, January 19 \| 4:30PM - 5:00PM Coffee Available Room: Concourse
Sunday, January 19 \| 5:00PM - 7:00PM Mechanisms of T Cell Evasion Room: Eldorado Grand Ballroom Speaker 1 of 6 * Daniel L. Barber, NIAID, National Institutes of Health, USA
Sunday, January 19 \| 5:00PM - 7:00PM Mechanisms of T Cell Evasion Room: Eldorado Grand Ballroom Speaker 2 of 6 Joel D. Ernst, University of California, San Francisco, USA Partners of T Cells: Functional Diversity of Mononuclear Phagocytes in Chronic M. tuberculosis Infection
Sunday, January 19 \| 5:00PM - 7:00PM Mechanisms of T Cell Evasion Room: Eldorado Grand Ballroom Speaker 3 of 6 Samuel M. Behar, University of Massachusetts Medical School, USA Differential Presentation of M. tuberculosis Antigens to T Cells During Priming and Chronic Infection
Sunday, January 19 \| 5:00PM - 7:00PM Mechanisms of T Cell Evasion Room: Eldorado Grand Ballroom Speaker 4 of 6 Kevin B. Urdahl, Seattle Children's Research Institute, USA Barriers to Immunity in the TB Granuloma
Sunday, January 19 \| 5:00PM - 7:00PM Mechanisms of T Cell Evasion Room: Eldorado Grand Ballroom Speaker 5 of 6 Björn Corleis, Friedrich-Loeffler Institute, Germany Short Talk: Tobacco Smoke Leads to Recruitment of Inflammatory Monocytes into the Alveolar Space and Accelerates Growth of Mycobacterium Tuberculosis
Sunday, January 19 \| 5:00PM - 7:00PM Mechanisms of T Cell Evasion Room: Eldorado Grand Ballroom Speaker 6 of 6 Ana Beatriz Enriquez, Emory University, USA Short Talk: Mycobacterium tuberculosis Modulation of Notch Ligand Expression Impedes Dendritic Cell-T Cell Crosstalk and Limits Th17 Polarization
Sunday, January 19 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Anasazi Ballroom No registration fees are used to fund alcohol served at this function.
Sunday, January 19 \| 7:30PM - 10:00PM Poster Session 3 Room: Anasazi Ballroom
Monday, January 20 \| 7:00AM - 8:00AM Breakfast Room: Anasazi Ballroom
Monday, January 20 \| 8:00AM - 11:00AM Pathogen Determinants of Immune Evasion Room: Eldorado Grand Ballroom Speaker 1 of 8 * Jennifer Philips, Washington University School of Medicine, USA
Monday, January 20 \| 8:00AM - 11:00AM Pathogen Determinants of Immune Evasion Room: Eldorado Grand Ballroom Speaker 2 of 8 Steven A. Porcelli, Albert Einstein College of Medicine, USA Mycobacterial PE_PGRS Proteins in Evasion of Innate and Adaptive Immunity
Monday, January 20 \| 8:00AM - 11:00AM Pathogen Determinants of Immune Evasion Room: Eldorado Grand Ballroom Speaker 3 of 8 Olivier Neyrolles, IPBS, CNRS-University of Toulouse, France C-Type Lectin Receptors in Immunity to Tuberculosis
Monday, January 20 \| 8:00AM - 11:00AM Pathogen Determinants of Immune Evasion Room: Eldorado Grand Ballroom Coffee Break
Monday, January 20 \| 8:00AM - 11:00AM Pathogen Determinants of Immune Evasion Room: Eldorado Grand Ballroom Speaker 5 of 8 Maximiliano Gutierrez, Francis Crick Institute, UK Mycobacterium tuberculosis Evasion of Xenophagy in the Cytosol of Host Cells
Monday, January 20 \| 8:00AM - 11:00AM Pathogen Determinants of Immune Evasion Room: Eldorado Grand Ballroom Speaker 6 of 8 Oren S. Rosenberg, University of California, San Francisco, USA TB from the Inside Out: Structural Biology of ESX Secretion
Monday, January 20 \| 8:00AM - 11:00AM Pathogen Determinants of Immune Evasion Room: Eldorado Grand Ballroom Speaker 7 of 8 Volker Briken, University of Maryland, USA Short Talk: A Molecular Mechanism of Mycobacterium tuberculosis Mediated Inflammasome Inhibition
Monday, January 20 \| 8:00AM - 11:00AM Pathogen Determinants of Immune Evasion Room: Eldorado Grand Ballroom Speaker 8 of 8 Jeffrey Buter, University of Groningen, Netherlands Short Talk: M. Tuberculosis Antacids Block Autophagy and Promote Lipid Accumulation in Foamy Macrophages
Monday, January 20 \| 11:00AM - 5:00PM On Own for Lunch
Monday, January 20 \| 3:00PM - 4:30PM Workshop 3: New Technologies and Models in TB Immunity Room: Eldorado Grand Ballroom Speaker 1 of 7 * Oren S. Rosenberg, University of California, San Francisco, USA
Monday, January 20 \| 3:00PM - 4:30PM Workshop 3: New Technologies and Models in TB Immunity Room: Eldorado Grand Ballroom Speaker 2 of 7 Amanda J. Martinot, Tufts Cummings School of Veterinary Medicine, USA Cyclic Immunofluorescence: in situ Multiplex Immunophenotyping of Cells in TB Granulomas
Monday, January 20 \| 3:00PM - 4:30PM Workshop 3: New Technologies and Models in TB Immunity Room: Eldorado Grand Ballroom Speaker 3 of 7 Erin F. McCaffrey, Stanford University, USA Characterization of the Composition and Structure of Human Tuberculosis Granulomas with Multiplexed Ion Beam Imaging
Monday, January 20 \| 3:00PM - 4:30PM Workshop 3: New Technologies and Models in TB Immunity Room: Eldorado Grand Ballroom Speaker 4 of 7 Sherry L. Kurtz, Food & Drug Administration, USA Genetically Diverse DO Mice Are a Novel Model for Studying Tuberculosis Vaccines and for Defining Genetic Traits Associated with Vaccine-Induced Protection
Monday, January 20 \| 3:00PM - 4:30PM Workshop 3: New Technologies and Models in TB Immunity Room: Eldorado Grand Ballroom Speaker 5 of 7 Mohamed Ahmed, Africa Health Research Institute, South Africa Sensing of Interferon-gamma by Mycobacterium tuberculosis
Monday, January 20 \| 3:00PM - 4:30PM Workshop 3: New Technologies and Models in TB Immunity Room: Eldorado Grand Ballroom Speaker 6 of 7 Paulo Bettencourt, University of Oxford, UK Immunopeptidomics-Based Identification of Antigens Presented by MHC-I and MHC-II for Vaccines against Tuberculosis
Monday, January 20 \| 3:00PM - 4:30PM Workshop 3: New Technologies and Models in TB Immunity Room: Eldorado Grand Ballroom Speaker 7 of 7 Mark Hatherill, University of Cape Town, South Africa Biomarker-Targeted Tuberculosis Preventive Therapy: A Randomized, Partially-Blinded Clinical Trial
Monday, January 20 \| 4:30PM - 5:00PM Coffee Available Room: Concourse
Monday, January 20 \| 5:00PM - 6:45PM Trained Immunity and Control of TB Room: Eldorado Grand Ballroom Speaker 1 of 4 Mihai G. Netea, Radboud University, Netherlands Trained Immunity: A Memory for Innate Host Defense
Monday, January 20 \| 5:00PM - 6:45PM Trained Immunity and Control of TB Room: Eldorado Grand Ballroom Speaker 2 of 4 Maziar Divangahi, McGill University, Canada M. tuberculosis Reprograms HSCs to Limit Myelopoiesis and Impair Trained Immunity
Monday, January 20 \| 5:00PM - 6:45PM Trained Immunity and Control of TB Room: Eldorado Grand Ballroom Speaker 3 of 4 Simone A. Joosten, Leiden University Medical Center, Netherlands Trained Immunity in TB Exposure
Monday, January 20 \| 5:00PM - 6:45PM Trained Immunity and Control of TB Room: Eldorado Grand Ballroom Speaker 4 of 4 * Alissa C. Rothchild, University of Massachusetts Amherst, USA Short Talk: Alveolar Macrophages Up-Regulate a Non-Classical Innate Response to Mycobacterium tuberculosis Infection in vivo
Monday, January 20 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Eldorado Grand Ballroom
Monday, January 20 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Anasazi Ballroom No registration fees are used to fund alcohol served at this function.
Monday, January 20 \| 8:00PM - 11:00PM Entertainment Room: Anasazi Ballroom Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Tuesday, January 21 \| 10:24AM - 10:24AM Departure *Session Chair.