Web Desc
Tuberculosis: Immunity and Immune Evasion
Organizer(s): Joel Ernst, Jennifer Philips and Daniel L. Barber
Date: January 16 - 20, 2020
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Tuberculosis remains the most common fatal infectious disease worldwide due to the absence of a sufficiently effective vaccine. Two critical barriers to the development of an effective TB vaccine are the incomplete understanding of the mechanisms of protective immunity to TB, and of the mechanisms of immune evasion by M. tuberculosis. The interactions among speakers and attendees at this conference will promote collaborations between scientists with complementary expertise who work in geographically distinct institutions, including those in high TB burden regions. This conference will present new findings on mechanisms of protective immunity to M. tuberculosis, and promote dialogue between immunologists and scientists in different areas of expertise to fill gaps in knowledge. Participants will also discuss advances in TB vaccine development and vaccine immunology. Finally, this conference will cover advances in other fields of immunology and other infectious diseases characterized by pathogen persistence, which will help to inform development of effective TB vaccines.
Global Health Travel Award Deadline: August 13 2019
Scholarship Deadline: September 24 2019
Discounted Abstract Deadline: September 24 2019
Abstract Deadline: October 16 2019
Discounted Registration Deadline: November 19 2019
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates Foundation
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI147619-01
Funding for this conference was made possible (in part) by 1R13AI147619-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, January 16 | 4:00PM - 8:00PM
Arrival and Registration
Room: Cava Santa Fe


Thursday, January 16 | 6:00PM - 8:00PM
Welcome Mixer
Room: Cava Santa Fe
No registration fees are used to fund alcohol served at this function.

Friday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Friday, January 17 | 7:30AM - 8:00AM
Poster Setup
Room: Anasazi Ballroom


Friday, January 17 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado Grand Ballroom

Speaker 2 of 2
Eric Goosby, University of California, San Francisco / United Nations, USA
Global Solutions to Elimination of Tuberculosis: The Roles of Immunology and Vaccines

Friday, January 17 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado Grand Ballroom

Speaker 1 of 2
* Joel D. Ernst, University of California, San Francisco, USA

Friday, January 17 | 8:00AM - 7:00PM
Poster Viewing
Room: Anasazi Ballroom


Friday, January 17 | 9:00AM - 11:00AM
TB Vaccines and Vaccine Immunology
Room: Eldorado Grand Ballroom

Speaker 5 of 5
Ann M. Ginsberg, BMGF, USA
TB Vaccine Human Efficacy Trials: What Have We Learned? Where Are We Headed?

Friday, January 17 | 9:00AM - 11:00AM
TB Vaccines and Vaccine Immunology
Room: Eldorado Grand Ballroom

Speaker 4 of 5
Thomas J. Scriba, University of Cape Town, South Africa
Immune Responses to Diverse TB Vaccines in Humans

Friday, January 17 | 9:00AM - 11:00AM
TB Vaccines and Vaccine Immunology
Room: Eldorado Grand Ballroom


Coffee Break

Friday, January 17 | 9:00AM - 11:00AM
TB Vaccines and Vaccine Immunology
Room: Eldorado Grand Ballroom

Speaker 2 of 5
Patricia A. Darrah, NIAID, National Institutes of Health, USA
Evaluating Mechanisms of Protection after Intravenous BCG Immunization in Nonhuman Primates

Friday, January 17 | 9:00AM - 11:00AM
TB Vaccines and Vaccine Immunology
Room: Eldorado Grand Ballroom

Speaker 1 of 5
* Joel D. Ernst, University of California, San Francisco, USA

Friday, January 17 | 11:00AM - 12:30PM
Lunch
Room: Anasazi Ballroom


Friday, January 17 | 12:00PM - 2:30PM
Poster Session 1
Room: Anasazi Ballroom


Friday, January 17 | 2:30PM - 4:30PM
Workshop 1: Moving Beyond Th1 Immunity in TB
Room: Eldorado Grand Ballroom

Speaker 8 of 9
Michael C. Kiritsy, University of Massachusetts Medical School, USA
Dissecting Host Innate Immunity to Tuberculosis Using Engineered and Natural Genetic Variation

Friday, January 17 | 2:30PM - 4:30PM
Workshop 1: Moving Beyond Th1 Immunity in TB
Room: Eldorado Grand Ballroom

Speaker 7 of 9
David M. Lewinsohn, Oregon Health & Science University, USA
Presentation of Mtb-Derived Antigens to MR1T Cells: A Unique Role for Endosomal Trafficking, and an Inhibitory Role for the MR1B Splice Variant

Friday, January 17 | 2:30PM - 4:30PM
Workshop 1: Moving Beyond Th1 Immunity in TB
Room: Eldorado Grand Ballroom

Speaker 6 of 9
Shunsuke Sakai, NIAID, National Institutes of Health, USA
Immunoregulatory and Host-Protective Functions of MAIT Cells during Mycobacterium tuberculosis Infection

Friday, January 17 | 2:30PM - 4:30PM
Workshop 1: Moving Beyond Th1 Immunity in TB
Room: Eldorado Grand Ballroom

Speaker 5 of 9
Paula Ruibal, Leiden University Medical Center, Netherlands
Identification of Novel HLA-E Binding Mtb-Derived Peptides as Potential Vaccine Candidates

Friday, January 17 | 2:30PM - 4:30PM
Workshop 1: Moving Beyond Th1 Immunity in TB
Room: Eldorado Grand Ballroom

Speaker 4 of 9
Rachel L. Tanner, University of Oxford, UK
Characterising the BCG-Induced Humoral Immune Response to Inform the Design of Improved TB Vaccines

Friday, January 17 | 2:30PM - 4:30PM
Workshop 1: Moving Beyond Th1 Immunity in TB
Room: Eldorado Grand Ballroom

Speaker 3 of 9
Hao Li, China Agricultural University, China
Isolation and Functional Characterization of Fully Human Protective Monoclonal Antibodies Directed against the Surface of Mycobacterium tuberculosis

Friday, January 17 | 2:30PM - 4:30PM
Workshop 1: Moving Beyond Th1 Immunity in TB
Room: Eldorado Grand Ballroom

Speaker 2 of 9
Shi-Hsia Hwa, Africa Health Research Institute, South Africa
Human Serum and Monoclonal Antibodies Can Inhibit Intracellular Mycobacterium Tuberculosis Growth and Promote Phagocyte Survival

Friday, January 17 | 2:30PM - 4:30PM
Workshop 1: Moving Beyond Th1 Immunity in TB
Room: Eldorado Grand Ballroom

Speaker 1 of 9
* Andrew Olive, Michigan State University, USA

Friday, January 17 | 2:30PM - 4:30PM
Workshop 1: Moving Beyond Th1 Immunity in TB
Room: Eldorado Grand Ballroom

Speaker 9 of 9
Daniel F. Hoft, St. Louis University, USA
A Human BCG Challenge Model to Assess TB Vaccines and Identify Immune Biomarkers

Friday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Friday, January 17 | 5:00PM - 7:00PM
Impact of Host and Pathogen Diversity
Room: Eldorado Grand Ballroom

Speaker 1 of 5
* Thuong T. T. Nguyen, Oxford University Clinical Research Unit, Vietnam

Friday, January 17 | 5:00PM - 7:00PM
Impact of Host and Pathogen Diversity
Room: Eldorado Grand Ballroom

Speaker 2 of 5
Chetan Seshadri, University of Washington, USA
IFN-?-Independent Immune Markers of Mycobacterium tuberculosis Exposure

Friday, January 17 | 5:00PM - 7:00PM
Impact of Host and Pathogen Diversity
Room: Eldorado Grand Ballroom

Speaker 3 of 5
Sara Suliman, Brigham and Women's Hospital, USA
Human Genetic and Transcriptional Correlates of TB Progression

Friday, January 17 | 5:00PM - 7:00PM
Impact of Host and Pathogen Diversity
Room: Eldorado Grand Ballroom

Speaker 4 of 5
Shabaana A. Khader, Washington University School of Medicine, USA
Role of Innate Lymphoid Cells in Tuberculosis

Friday, January 17 | 5:00PM - 7:00PM
Impact of Host and Pathogen Diversity
Room: Eldorado Grand Ballroom

Speaker 5 of 5
Sarah M. Fortune, Harvard TH Chan School of Public Health, USA
Single Cell RNAseq Reveals Novel Correlates of TB Granuloma Fate

Saturday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Saturday, January 18 | 8:00AM - 11:00AM
Mechanisms of T Cell Protection
Room: Eldorado Grand Ballroom

Speaker 1 of 8
* Cheryl L. Day, Emory University, USA

Saturday, January 18 | 8:00AM - 11:00AM
Mechanisms of T Cell Protection
Room: Eldorado Grand Ballroom

Speaker 2 of 8
Marc K. Jenkins, University of Minnesota Medical School, USA
CD4+ T Cell-Based Control of a Phagosomal Pathogen

Saturday, January 18 | 8:00AM - 11:00AM
Mechanisms of T Cell Protection
Room: Eldorado Grand Ballroom

Speaker 3 of 8
Cecilia S. Lindestam Arlehamn, La Jolla Institute for Allergy and Immunology, USA
T Cell Transcriptomics Reveal Immune Signatures of Tuberculosis

Saturday, January 18 | 8:00AM - 11:00AM
Mechanisms of T Cell Protection
Room: Eldorado Grand Ballroom


Coffee Break

Saturday, January 18 | 8:00AM - 11:00AM
Mechanisms of T Cell Protection
Room: Eldorado Grand Ballroom

Speaker 5 of 8
Daniel L. Barber, NIAID, National Institutes of Health, USA
Protective CD4 T Cell Responses to M. tuberculosis Infection

Saturday, January 18 | 8:00AM - 11:00AM
Mechanisms of T Cell Protection
Room: Eldorado Grand Ballroom

Speaker 6 of 8
Paul Ogongo, University of California, San Francisco, USA
Compartmentalization of M. tuberculosis-Specific Human T-Cells in the Lung

Saturday, January 18 | 8:00AM - 11:00AM
Mechanisms of T Cell Protection
Room: Eldorado Grand Ballroom

Speaker 7 of 8
Munyaradzi Nyasha Musvosvi, University of Cape Town, South Africa
Short Talk: Mycobacteria-Specific T Cell Receptor Clonotypes Associated with Mycobacterium tuberculosis Infection Outcome

Saturday, January 18 | 8:00AM - 11:00AM
Mechanisms of T Cell Protection
Room: Eldorado Grand Ballroom

Speaker 8 of 8
Christine Nelson, NIAID, National Institutes of Health, USA
Short Talk: CD226 and CD28 Have Opposing Roles in the Generation of Lung-Homing CD4 T Cells during M. tuberculosis Infection

Saturday, January 18 | 11:00AM - 5:00PM
On Own for Lunch


Saturday, January 18 | 11:00AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Saturday, January 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Saturday, January 18 | 3:00PM - 4:30PM
Workshop 2: Impact of Coinfections and Comorbidities on TB I
mmunity
Room: Eldorado Grand Ballroom

Speaker 1 of 7
* Blanca I. Restrepo, University of Texas HSC Houston, Brownsville Campus, USA

Saturday, January 18 | 3:00PM - 4:30PM
Workshop 2: Impact of Coinfections and Comorbidities on TB I
mmunity
Room: Eldorado Grand Ballroom

Speaker 2 of 7
Taryn A. McLaughlin, Emory University, USA
CD4 T Cells in Mycobacterium tuberculosis and Schistosoma Mansoni Co-Infected Individuals Maintain Functional TH1 Responses

Saturday, January 18 | 3:00PM - 4:30PM
Workshop 2: Impact of Coinfections and Comorbidities on TB I
mmunity
Room: Eldorado Grand Ballroom

Speaker 4 of 7
Mohau Steven Makatsa, University of Cape Town, South Africa
Characterization of Mtb-Specific Th22 Cells in HIV and TB Co-Infection

Saturday, January 18 | 3:00PM - 4:30PM
Workshop 2: Impact of Coinfections and Comorbidities on TB I
mmunity
Room: Eldorado Grand Ballroom

Speaker 3 of 7
Deepak Tripathi, University of Texas Health Science Center at Tyler, USA
IL-22 Produced by Type 3 Innate Lymphoid Cells (ILC3s) Reduces the Mortality of Type 2 Diabetes Mellitus (T2DM) Mice Infected with Mycobacterium tuberculosis

Saturday, January 18 | 3:00PM - 4:30PM
Workshop 2: Impact of Coinfections and Comorbidities on TB I
mmunity
Room: Eldorado Grand Ballroom

Speaker 6 of 7
Charles A. Scanga, University of Pittsburgh School of Medicine, USA
Vaccination with Intravenous BCG Confers Remarkable Protection from Tuberculosis in SIV+ Macaques

Saturday, January 18 | 3:00PM - 4:30PM
Workshop 2: Impact of Coinfections and Comorbidities on TB I
mmunity
Room: Eldorado Grand Ballroom

Speaker 7 of 7
Robert Blomgran, Linköping University, Sweden
Beneficial Effects of Helminth Antigen Exposure for the Control of Mycobacterium tuberculosis Infection in Monocytes and Macrophages, Contrasting the Effect of Chronic Helminth Infection

Saturday, January 18 | 3:00PM - 4:30PM
Workshop 2: Impact of Coinfections and Comorbidities on TB I
mmunity
Room: Eldorado Grand Ballroom

Speaker 5 of 7
Susana Benet, Irsicaixa, Spain
Impact of Siglec-1 Variant on Disseminated Tuberculosis during HIV-1 Co-Infection

Saturday, January 18 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Saturday, January 18 | 5:00PM - 7:15PM
Immunometabolism and Host-Directed Therapies
Room: Eldorado Grand Ballroom

Speaker 1 of 7
* Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands

Saturday, January 18 | 5:00PM - 7:15PM
Immunometabolism and Host-Directed Therapies
Room: Eldorado Grand Ballroom

Speaker 2 of 7
Amit Singhal, Singapore Immunology Network, Singapore
Reprograming Host Immunometabolic Circuits for Designing TB HDT

Saturday, January 18 | 5:00PM - 7:15PM
Immunometabolism and Host-Directed Therapies
Room: Eldorado Grand Ballroom

Speaker 3 of 7
Sarah A. Stanley, University of California, Berkeley, USA
Metabolic Regulation of Macrophage Activation during Mtb Infection

Saturday, January 18 | 5:00PM - 7:15PM
Immunometabolism and Host-Directed Therapies
Room: Eldorado Grand Ballroom

Speaker 4 of 7
Jennifer Philips, Washington University School of Medicine, USA
Targeting Host Metabolism to Treat TB

Saturday, January 18 | 5:00PM - 7:15PM
Immunometabolism and Host-Directed Therapies
Room: Eldorado Grand Ballroom

Speaker 5 of 7
Jeffey M. Collins, Emory University School of Medicine, USA
Short Talk: Tryptophan Catabolism Reflects Disease Activity and Treatment Response in Latent Infection and Active Disease Caused by Mycobacterium tuberculosis

Saturday, January 18 | 5:00PM - 7:15PM
Immunometabolism and Host-Directed Therapies
Room: Eldorado Grand Ballroom

Speaker 6 of 7
Katharina Ronacher, University of Queensland, Australia
Short Talk: Identification of a Putative Target for Host-Directed Therapy: A Cholesterol Receptor Regulates Interferons and Bacterial Growth during M. tuberculosis Infection

Saturday, January 18 | 5:00PM - 7:15PM
Immunometabolism and Host-Directed Therapies
Room: Eldorado Grand Ballroom

Speaker 7 of 7
Hua Yang, Shanghai Pulmonary Hospital, Tongji University School of Medicine, China
Short Talk: Interception of Host Fatty Acid Metabolism by Mycobacteria Under Hypoxia to Suppress Anti-TB Immunity

Saturday, January 18 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Saturday, January 18 | 7:30PM - 10:00PM
Poster Session 2
Room: Anasazi Ballroom


Sunday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Sunday, January 19 | 8:00AM - 11:15AM
Lessons from Beyond TB
Room: Eldorado Grand Ballroom

Speaker 1 of 9
* Sarah A. Stanley, University of California, Berkeley, USA

Sunday, January 19 | 8:00AM - 11:15AM
Lessons from Beyond TB
Room: Eldorado Grand Ballroom

Speaker 2 of 9
Steven M. Holland, NIAID, National Institutes of Health, USA
Are Infections in the Lung and Outside it the Same? Host Factors in Mycobacterial Tissue Specificity

Sunday, January 19 | 8:00AM - 11:15AM
Lessons from Beyond TB
Room: Eldorado Grand Ballroom

Speaker 3 of 9
Nevil J. Singh, University of Maryland, USA
The Signaling Logic Regulating T Cell Responses to Persistent Antigens

Sunday, January 19 | 8:00AM - 11:15AM
Lessons from Beyond TB
Room: Eldorado Grand Ballroom


Coffee Break

Sunday, January 19 | 8:00AM - 11:15AM
Lessons from Beyond TB
Room: Eldorado Grand Ballroom

Speaker 5 of 9
David L. Sacks, NIAID, National Institutes of Health, USA
Dermis Resident Macrophages are Maintained as a Replicative Niche for Leishmania in a Th1 Immune Environment

Sunday, January 19 | 8:00AM - 11:15AM
Lessons from Beyond TB
Room: Eldorado Grand Ballroom

Speaker 6 of 9
Haina Shin, Washington University, USA
Distinct Host Restriction of HSV-1 and HSV-2 Genital Herpes

Sunday, January 19 | 8:00AM - 11:15AM
Lessons from Beyond TB
Room: Eldorado Grand Ballroom

Speaker 7 of 9
Lara Mittereder, Food and Drug Administration, USA
Short Talk: Primed Lymphocytes That Control Intramacrophage Bacterial Replication Shift Metabolism toward Glycolysis

Sunday, January 19 | 8:00AM - 11:15AM
Lessons from Beyond TB
Room: Eldorado Grand Ballroom

Speaker 8 of 9
Erika J. Hughes, Duke University, USA
Short Talk: Single-Cell RNA-Seq of Zebrafish Granulomas Reveals Altered Cell Composition and Inflammatory Expression Profiles Associated with Dysregulated Eicosanoid Signaling

Sunday, January 19 | 8:00AM - 11:15AM
Lessons from Beyond TB
Room: Eldorado Grand Ballroom

Speaker 9 of 9
Ya-Ting Wang, Washington University School of Medicine, USA
Short Talk: Redefining the Role of Autophagy in Infectious Disease

Sunday, January 19 | 11:15AM - 5:00PM
On Own for Lunch


Sunday, January 19 | 11:15AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Sunday, January 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Sunday, January 19 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Sunday, January 19 | 5:00PM - 7:00PM
Mechanisms of T Cell Evasion
Room: Eldorado Grand Ballroom

Speaker 1 of 6
* Daniel L. Barber, NIAID, National Institutes of Health, USA

Sunday, January 19 | 5:00PM - 7:00PM
Mechanisms of T Cell Evasion
Room: Eldorado Grand Ballroom

Speaker 2 of 6
Joel D. Ernst, University of California, San Francisco, USA
Partners of T Cells: Functional Diversity of Mononuclear Phagocytes in Chronic M. tuberculosis Infection

Sunday, January 19 | 5:00PM - 7:00PM
Mechanisms of T Cell Evasion
Room: Eldorado Grand Ballroom

Speaker 3 of 6
Samuel M. Behar, University of Massachusetts Medical School, USA
Differential Presentation of M. tuberculosis Antigens to T Cells During Priming and Chronic Infection

Sunday, January 19 | 5:00PM - 7:00PM
Mechanisms of T Cell Evasion
Room: Eldorado Grand Ballroom

Speaker 4 of 6
Kevin B. Urdahl, Seattle Children's Research Institute, USA
Barriers to Immunity in the TB Granuloma

Sunday, January 19 | 5:00PM - 7:00PM
Mechanisms of T Cell Evasion
Room: Eldorado Grand Ballroom

Speaker 5 of 6
Björn Corleis, Friedrich-Loeffler Institute, Germany
Short Talk: Tobacco Smoke Leads to Recruitment of Inflammatory Monocytes into the Alveolar Space and Accelerates Growth of Mycobacterium Tuberculosis

Sunday, January 19 | 5:00PM - 7:00PM
Mechanisms of T Cell Evasion
Room: Eldorado Grand Ballroom

Speaker 6 of 6
Ana Beatriz Enriquez, Emory University, USA
Short Talk: Mycobacterium tuberculosis Modulation of Notch Ligand Expression Impedes Dendritic Cell-T Cell Crosstalk and Limits Th17 Polarization

Sunday, January 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Sunday, January 19 | 7:30PM - 10:00PM
Poster Session 3
Room: Anasazi Ballroom


Monday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Monday, January 20 | 8:00AM - 11:00AM
Pathogen Determinants of Immune Evasion
Room: Eldorado Grand Ballroom

Speaker 1 of 8
* Jennifer Philips, Washington University School of Medicine, USA

Monday, January 20 | 8:00AM - 11:00AM
Pathogen Determinants of Immune Evasion
Room: Eldorado Grand Ballroom

Speaker 2 of 8
Steven A. Porcelli, Albert Einstein College of Medicine, USA
Mycobacterial PE_PGRS Proteins in Evasion of Innate and Adaptive Immunity

Monday, January 20 | 8:00AM - 11:00AM
Pathogen Determinants of Immune Evasion
Room: Eldorado Grand Ballroom

Speaker 3 of 8
Olivier Neyrolles, IPBS, CNRS-University of Toulouse, France
C-Type Lectin Receptors in Immunity to Tuberculosis

Monday, January 20 | 8:00AM - 11:00AM
Pathogen Determinants of Immune Evasion
Room: Eldorado Grand Ballroom


Coffee Break

Monday, January 20 | 8:00AM - 11:00AM
Pathogen Determinants of Immune Evasion
Room: Eldorado Grand Ballroom

Speaker 5 of 8
Maximiliano Gutierrez, Francis Crick Institute, UK
Mycobacterium tuberculosis Evasion of Xenophagy in the Cytosol of Host Cells

Monday, January 20 | 8:00AM - 11:00AM
Pathogen Determinants of Immune Evasion
Room: Eldorado Grand Ballroom

Speaker 6 of 8
Oren S. Rosenberg, University of California, San Francisco, USA
TB from the Inside Out: Structural Biology of ESX Secretion

Monday, January 20 | 8:00AM - 11:00AM
Pathogen Determinants of Immune Evasion
Room: Eldorado Grand Ballroom

Speaker 7 of 8
Volker Briken, University of Maryland, USA
Short Talk: A Molecular Mechanism of Mycobacterium tuberculosis Mediated Inflammasome Inhibition

Monday, January 20 | 8:00AM - 11:00AM
Pathogen Determinants of Immune Evasion
Room: Eldorado Grand Ballroom

Speaker 8 of 8
Jeffrey Buter, University of Groningen, Netherlands
Short Talk: M. Tuberculosis Antacids Block Autophagy and Promote Lipid Accumulation in Foamy Macrophages

Monday, January 20 | 11:00AM - 5:00PM
On Own for Lunch


Monday, January 20 | 3:00PM - 4:30PM
Workshop 3: New Technologies and Models in TB Immunity
Room: Eldorado Grand Ballroom

Speaker 1 of 7
* Oren S. Rosenberg, University of California, San Francisco, USA

Monday, January 20 | 3:00PM - 4:30PM
Workshop 3: New Technologies and Models in TB Immunity
Room: Eldorado Grand Ballroom

Speaker 2 of 7
Amanda J. Martinot, Tufts Cummings School of Veterinary Medicine, USA
Cyclic Immunofluorescence: in situ Multiplex Immunophenotyping of Cells in TB Granulomas

Monday, January 20 | 3:00PM - 4:30PM
Workshop 3: New Technologies and Models in TB Immunity
Room: Eldorado Grand Ballroom

Speaker 3 of 7
Erin F. McCaffrey, Stanford University, USA
Characterization of the Composition and Structure of Human Tuberculosis Granulomas with Multiplexed Ion Beam Imaging

Monday, January 20 | 3:00PM - 4:30PM
Workshop 3: New Technologies and Models in TB Immunity
Room: Eldorado Grand Ballroom

Speaker 4 of 7
Sherry L. Kurtz, Food & Drug Administration, USA
Genetically Diverse DO Mice Are a Novel Model for Studying Tuberculosis Vaccines and for Defining Genetic Traits Associated with Vaccine-Induced Protection

Monday, January 20 | 3:00PM - 4:30PM
Workshop 3: New Technologies and Models in TB Immunity
Room: Eldorado Grand Ballroom

Speaker 5 of 7
Mohamed Ahmed, Africa Health Research Institute, South Africa
Sensing of Interferon-gamma by Mycobacterium tuberculosis

Monday, January 20 | 3:00PM - 4:30PM
Workshop 3: New Technologies and Models in TB Immunity
Room: Eldorado Grand Ballroom

Speaker 6 of 7
Paulo Bettencourt, University of Oxford, UK
Immunopeptidomics-Based Identification of Antigens Presented by MHC-I and MHC-II for Vaccines against Tuberculosis

Monday, January 20 | 3:00PM - 4:30PM
Workshop 3: New Technologies and Models in TB Immunity
Room: Eldorado Grand Ballroom

Speaker 7 of 7
Mark Hatherill, University of Cape Town, South Africa
Biomarker-Targeted Tuberculosis Preventive Therapy: A Randomized, Partially-Blinded Clinical Trial

Monday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Monday, January 20 | 5:00PM - 6:45PM
Trained Immunity and Control of TB
Room: Eldorado Grand Ballroom

Speaker 1 of 4
Mihai G. Netea, Radboud University, Netherlands
Trained Immunity: A Memory for Innate Host Defense


Monday, January 20 | 5:00PM - 6:45PM
Trained Immunity and Control of TB
Room: Eldorado Grand Ballroom

Speaker 2 of 4
Maziar Divangahi, McGill University, Canada
M. tuberculosis Reprograms HSCs to Limit Myelopoiesis and Impair Trained Immunity

Monday, January 20 | 5:00PM - 6:45PM
Trained Immunity and Control of TB
Room: Eldorado Grand Ballroom

Speaker 3 of 4
Simone A. Joosten, Leiden University Medical Center, Netherlands
Trained Immunity in TB Exposure

Monday, January 20 | 5:00PM - 6:45PM
Trained Immunity and Control of TB
Room: Eldorado Grand Ballroom

Speaker 4 of 4
* Alissa C. Rothchild, University of Massachusetts Amherst, USA
Short Talk: Alveolar Macrophages Up-Regulate a Non-Classical Innate Response to Mycobacterium tuberculosis Infection in vivo

Monday, January 20 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Eldorado Grand Ballroom


Monday, January 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, January 20 | 8:00PM - 11:00PM
Entertainment
Room: Anasazi Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Tuesday, January 21 | 10:24AM - 10:24AM
Departure


*Session Chair.