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Web Desc
Tissue Immunity
Organizer(s): Bana Jabri, Daniel Mucida and Ramnik Xavier
Date: January 26 - 29, 2020
Location: Embassy Suites by Hilton Boulder, Boulder, CO, USA
Sponsored by AbbVie Inc., Akebia Therapeutics, BioLegend, Inc., Merck & Co., Inc. and Pfizer Inc.
Summary of Meeting:
How tissues integrate host-microbial signals and regulate immune responses has a critical impact on health and disease. However, our understanding of tissue immunity is limited because of difficulties in accessing the different organs and also due to the inherent complexity and individuality of the cellular circuits present in different tissues. This conference will bring together scientists in the fields of mucosal immunology, neurology, microbiology, metabolism and systems biology. The conference will discuss (i) the diversity of tissue resident T cell subsets and their function and regulation, (ii) the regulation and role of mucosal B cell responses, (iii) the role of the nervous system in the regulation of tissue immunity, (iii) how tissues integrate metabolic and microbial cues to determine which type of immune response to mount, (iv) the existence of innate memory and its role in pathophysiology, and (v) new approaches in the study of tissue immunity. Because of the interdisciplinary nature of the conference and its focus on tissue immunity across organs and cell types, the conference will give investigators a broad perspective on tissue immunity and encourage them to go beyond the traditional disciplinary boundaries. An interactive workshop engage will engage industrial partners to define new approaches to prevent and treat inflammatory disorders and cancer and will highlight new frontiers in tissue immunity, cellular networks and inter-tissue communication in health and disease.
Scholarship Deadline: September 26 2019
Discounted Abstract Deadline: September 26 2019
Abstract Deadline: October 24 2019
Discounted Registration Deadline: November 21 2019
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AbbVie Inc.Akebia TherapeuticsBioLegend, Inc.Merck & Co., Inc.Pfizer Inc.
We gratefully acknowledge additional support from these exhibitors at this conference:
Bolder BioPATH, Inc.
We gratefully acknowledge additional support for this conference from:
American Association for Cancer Research (AACR)
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI147688-01
Funding for this conference was made possible (in part) by 1R13AI147688-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 26 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Sunday, January 26 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 27 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Pearl Street Ballroom

Speaker 2 of 2
Richard M. Locksley, HHMI/University of California, San Francisco, USA
Type 2 Immunity and Tissue Resilience

Monday, January 27 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Pearl Street Ballroom

Speaker 1 of 2
* Piotr Bielecki, Celsius Therapeutics, USA

Monday, January 27 | 9:30AM - 12:00PM
Tissue-Resident T Cells
Room: Pearl Street Ballroom

Speaker 6 of 6
Toufic Mayassi, University of Chicgao, USA
Insights into Tissue-Resident Immunity and Intraepithelial gamma delta Biology from Celiac Disease

Monday, January 27 | 9:30AM - 12:00PM
Tissue-Resident T Cells
Room: Pearl Street Ballroom

Speaker 5 of 6
Ivaylo I. Ivanov, Columbia University, USA
Dissecting the Differential Roles of ILC3 and T Cells in Mucosal Immunity

Monday, January 27 | 9:30AM - 12:00PM
Tissue-Resident T Cells
Room: Pearl Street Ballroom

Speaker 4 of 6
Laura K. Mackay, University of Melbourne, Australia
Targeting Tissue-Resident Memory T Cell Subsets

Monday, January 27 | 9:30AM - 12:00PM
Tissue-Resident T Cells
Room: Pearl Street Ballroom


Coffee Break

Monday, January 27 | 9:30AM - 12:00PM
Tissue-Resident T Cells
Room: Pearl Street Ballroom

Speaker 2 of 6
David B. Masopust, University of Minnesota, USA
Functions of Tissue Resident T Cells

Monday, January 27 | 9:30AM - 12:00PM
Tissue-Resident T Cells
Room: Pearl Street Ballroom

Speaker 1 of 6
* Daniel Mucida, Rockefeller University, USA

Monday, January 27 | 12:00PM - 1:00PM
Poster Setup
Room: Pearl Street Ballroom


Monday, January 27 | 12:00PM - 5:00PM
On Own for Lunch


Monday, January 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Pearl Street Ballroom


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Immune Responses across Tissues
Room: Pearl Street Ballroom

Speaker 10 of 10
Emily E. Thornton, University of Oxford, UK
Commensal-Reactive, IL-23 Responsive T Cells Promote Gut Barrier Immunity

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Immune Responses across Tissues
Room: Pearl Street Ballroom

Speaker 9 of 10
Madelene W. Dahlgren, University of California, San Francisco, USA
Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Immune Responses across Tissues
Room: Pearl Street Ballroom

Speaker 8 of 10
Angelina Bilate, Rockefeller University, USA
Instructive Role of the T Cell Receptor on Lymphocyte Plasticity at the Intestinal Border

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Immune Responses across Tissues
Room: Pearl Street Ballroom

Speaker 7 of 10
Zachary Earley, University of Chicago, USA
GATA4 Controls Regionalization of Intestinal Immunity Through Restricting Bacterial Colonization

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Immune Responses across Tissues
Room: Pearl Street Ballroom

Speaker 6 of 10
Jack McGinty, University of Washington, USA
Tuft Cell-Derived Leukotrienes Drive Rapid Activation of Anti-Helminth Immunity in the Small Intestine

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Immune Responses across Tissues
Room: Pearl Street Ballroom

Speaker 5 of 10
Susan Christo, University of Melbourne, Australia
The Local Microenvironment Drives the Identity of Tissue-Resident Memory T Cells

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Immune Responses across Tissues
Room: Pearl Street Ballroom

Speaker 4 of 10
Quynh Nguyen, University of California, San Diego, USA
Transcriptional Programming of Intestinal CD4+ Tissue-Resident Memory T Cells

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Immune Responses across Tissues
Room: Pearl Street Ballroom

Speaker 3 of 10
Nicholas Bessman, Weill Cornell Medicine, USA
Dendritic Cell-Derived Hepcidin Sequesters Iron from the Microbiota to Promote Mucosal Healing

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Immune Responses across Tissues
Room: Pearl Street Ballroom

Speaker 2 of 10
* Xingbin AI, Brigham & Women's Hospital, USA

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Immune Responses across Tissues
Room: Pearl Street Ballroom

Speaker 1 of 10
* Daria Esterházy, University of Chicago, USA

Monday, January 27 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, January 27 | 5:00PM - 7:00PM
Innate Memory in Tissues
Room: Pearl Street Ballroom

Speaker 1 of 6
* Fiona M. Powrie, University of Oxford, UK

Monday, January 27 | 5:00PM - 7:00PM
Innate Memory in Tissues
Room: Pearl Street Ballroom

Speaker 2 of 6
Mihai G. Netea, Radboud University, Netherlands
Trained Immunity: A Memory for Innate Host Defense

Monday, January 27 | 5:00PM - 7:00PM
Innate Memory in Tissues
Room: Pearl Street Ballroom

Speaker 3 of 6
Marco Colonna, Washington University School of Medicine, USA
Tissue Imprinting of Innate-Like-Lymphocytes

Monday, January 27 | 5:00PM - 7:00PM
Innate Memory in Tissues
Room: Pearl Street Ballroom

Speaker 4 of 6
Shruti Naik, New York University, USA
Inflammatory Memory in Epithelial Stem Cells

Monday, January 27 | 5:00PM - 7:00PM
Innate Memory in Tissues
Room: Pearl Street Ballroom

Speaker 5 of 6
Michael G. Constantinides, The Scripps Research Institute, USA
Short Talk: MAIT Cells are Imprinted by the Microbiota in Early Life and Promote Tissue Repair

Monday, January 27 | 5:00PM - 7:00PM
Innate Memory in Tissues
Room: Pearl Street Ballroom

Speaker 6 of 6
Judith Agudo, Dana-Farber Cancer Institute, USA
Short Talk: Quiescent Tissue-Resident Stem Cells Evade Immune Surveillance

Monday, January 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pearl Street Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, January 27 | 7:30PM - 10:00PM
Poster Session 1
Room: Pearl Street Ballroom


Tuesday, January 28 | 8:30AM - 11:30AM
Neuronal Control of Tissue Immunity
Room: Pearl Street Ballroom

Speaker 1 of 6
* Ramnik Xavier, Massachusetts General Hospital, USA
Microbial Metabolites in Health and Disease

Tuesday, January 28 | 8:30AM - 11:30AM
Neuronal Control of Tissue Immunity
Room: Pearl Street Ballroom

Speaker 2 of 6
Gloria Choi, Massachusetts Institute of Technology, USA
Neural Circuits and the Immune System

Tuesday, January 28 | 8:30AM - 11:30AM
Neuronal Control of Tissue Immunity
Room: Pearl Street Ballroom


Coffee Break

Tuesday, January 28 | 8:30AM - 11:30AM
Neuronal Control of Tissue Immunity
Room: Pearl Street Ballroom

Speaker 4 of 6
Daniel Mucida, Rockefeller University, USA
Adrenergic Signaling in Muscularis Macrophages Limits Neuronal Death Following Enteric Infection

Tuesday, January 28 | 8:30AM - 11:30AM
Neuronal Control of Tissue Immunity
Room: Pearl Street Ballroom

Speaker 5 of 6
Lorena Riol Blanco, Genentech, Inc., USA
Nodose Sensory Neurons Require TMC3 to Restrain Lung Damage

Tuesday, January 28 | 8:30AM - 11:30AM
Neuronal Control of Tissue Immunity
Room: Pearl Street Ballroom

Speaker 6 of 6
William Khoury-Hanold, Yale University, USA
Short Talk: Bitter Taste Sensing in the Gastrointestinal Tract Controls Allergic Sensitization

Tuesday, January 28 | 11:30AM - 5:00PM
On Own for Lunch


Tuesday, January 28 | 11:30AM - 1:00PM
Poster Setup
Room: Pearl Street Ballroom


Tuesday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Pearl Street Ballroom


Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Pearl Street Ballroom

Speaker 1 of 8
Shruti Naik, New York University, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Pearl Street Ballroom

Speaker 2 of 8
David B. Masopust, University of Minnesota, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Pearl Street Ballroom

Speaker 3 of 8
Daria Esterházy, University of Chicago, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Pearl Street Ballroom

Speaker 4 of 8
Dan A. Erkes, American Association for Cancer Research, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Pearl Street Ballroom

Speaker 5 of 8
Ramnik Xavier, Massachusetts General Hospital, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Pearl Street Ballroom

Speaker 6 of 8
Melissa Marie Walker, Bolder Biopath, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Pearl Street Ballroom

Speaker 7 of 8
Fiona M. Powrie, University of Oxford, UK

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Pearl Street Ballroom

Speaker 8 of 8
Ursula Weiss, Nature Publishing Group, UK

Tuesday, January 28 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, January 28 | 5:00PM - 7:00PM
Mucosal B Cell Responses
Room: Pearl Street Ballroom

Speaker 1 of 4
Matteo Iannacone, Fondazione Centro San Raffaele, Italy
Spatiotemporal Dynamics and Genomic Landscape of CD8+ T Cells Undergoing Intrahepatic Priming

Tuesday, January 28 | 5:00PM - 7:00PM
Mucosal B Cell Responses
Room: Pearl Street Ballroom

Speaker 2 of 4
* Ludvig M. Sollid, University of Oslo, Norway
Antigen-Specific B Cell Responses Implicated in Celiac Disease

Tuesday, January 28 | 5:00PM - 7:00PM
Mucosal B Cell Responses
Room: Pearl Street Ballroom

Speaker 3 of 4
Valerie Abadie, University of Chicago, USA
Contribution of the Humoral Response to the Pathogenesis of Celiac Disease

Tuesday, January 28 | 5:00PM - 7:00PM
Mucosal B Cell Responses
Room: Pearl Street Ballroom

Speaker 4 of 4
Priyadharshini Devarajan, University of Massachusetts Medical School, USA
Short Talk: Generation of Tissue-Restricted CD4 Effectors, TFH and ThCTL, Requires Signals from Antigen in the Tissue Site and from Infection at an Effector Checkpoint

Tuesday, January 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pearl Street Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, January 28 | 7:30PM - 10:00PM
Poster Session 2
Room: Pearl Street Ballroom


Wednesday, January 29 | 8:30AM - 11:45AM
Molecular and Metabolic Control of Inflammation
Room: Pearl Street Ballroom

Speaker 1 of 9
* Ramnik Xavier, Massachusetts General Hospital, USA

Wednesday, January 29 | 8:30AM - 11:45AM
Molecular and Metabolic Control of Inflammation
Room: Pearl Street Ballroom

Speaker 2 of 9
Daria Esterházy, University of Chicago, USA
Compartmentalization of Intestinal Immune Responses

Wednesday, January 29 | 8:30AM - 11:45AM
Molecular and Metabolic Control of Inflammation
Room: Pearl Street Ballroom

Speaker 3 of 9
Fiona M. Powrie, University of Oxford, UK
Talk Title to be Announced

Wednesday, January 29 | 8:30AM - 11:45AM
Molecular and Metabolic Control of Inflammation
Room: Pearl Street Ballroom


Coffee Break

Wednesday, January 29 | 8:30AM - 11:45AM
Molecular and Metabolic Control of Inflammation
Room: Pearl Street Ballroom

Speaker 5 of 9
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Krebs Cycle Reborn in Macrophages

Wednesday, January 29 | 8:30AM - 11:45AM
Molecular and Metabolic Control of Inflammation
Room: Pearl Street Ballroom

Speaker 6 of 9
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Influence of Nutrient Availability on Tissue Metabolism

Wednesday, January 29 | 8:30AM - 11:45AM
Molecular and Metabolic Control of Inflammation
Room: Pearl Street Ballroom

Speaker 7 of 9
Graham Barlow, Stanford University, USA
Short Talk: Hierarchical Tissue Factors Orchestrate Autoimmune Insulitis in Human Type I Diabetes

Wednesday, January 29 | 8:30AM - 11:45AM
Molecular and Metabolic Control of Inflammation
Room: Pearl Street Ballroom

Speaker 8 of 9
Jacqueline W. Mays, NIDCR, National Institutes of Health, USA
Short Talk: Tissue-Resident Memory T Cells May Drive the Pathogenesis of Exocrine Gland Chronic Graft-Versus-Host Disease

Wednesday, January 29 | 8:30AM - 11:45AM
Molecular and Metabolic Control of Inflammation
Room: Pearl Street Ballroom

Speaker 9 of 9
Eric Brown, Broad Institute of MIT and Harvard, USA
Short Talk: Intestinal Microbiome Sphingolipid Signaling Mediates Inflammation and Mucosal Immunity

Wednesday, January 29 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, January 29 | 2:30PM - 4:30PM
Workshop 2: New Approaches to Target Tissue Immunity in Auto
immunity and Cancer
Room: Pearl Street Ballroom

Speaker 1 of 10
* Shruti Naik, New York University, USA

Wednesday, January 29 | 2:30PM - 4:30PM
Workshop 2: New Approaches to Target Tissue Immunity in Auto
immunity and Cancer
Room: Pearl Street Ballroom

Speaker 2 of 10
* Ricardo R. Cibotti, NIAMS, National Institutes of Health, USA

Wednesday, January 29 | 2:30PM - 4:30PM
Workshop 2: New Approaches to Target Tissue Immunity in Auto
immunity and Cancer
Room: Pearl Street Ballroom

Speaker 3 of 10
Rafael Sanguinetti Czepielewski, Washington University School of Medicine, USA
Mesenteric Tertiary Lymphoid Organs Block Leukocyte Migration from the Intestine in a Crohn’s Disease-Like Mouse Model

Wednesday, January 29 | 2:30PM - 4:30PM
Workshop 2: New Approaches to Target Tissue Immunity in Auto
immunity and Cancer
Room: Pearl Street Ballroom

Speaker 4 of 10
Michel Enamorado, NIAID, National Institutes of Health, USA
Immunity - or Lack of - to Staphylococcus aureus

Wednesday, January 29 | 2:30PM - 4:30PM
Workshop 2: New Approaches to Target Tissue Immunity in Auto
immunity and Cancer
Room: Pearl Street Ballroom

Speaker 5 of 10
Yisu Gu, University of Oxford, UK
Spatial Compartmentalisation of Pathobiont-Reactive T Cell Differentiation in Gut Tissue

Wednesday, January 29 | 2:30PM - 4:30PM
Workshop 2: New Approaches to Target Tissue Immunity in Auto
immunity and Cancer
Room: Pearl Street Ballroom

Speaker 6 of 10
Duncan McKenzie, Francis Crick Institute, UK
A Two-Step Molecular Mechanism for Immune Discrimination of Tissue Dysregulation from Normality

Wednesday, January 29 | 2:30PM - 4:30PM
Workshop 2: New Approaches to Target Tissue Immunity in Auto
immunity and Cancer
Room: Pearl Street Ballroom

Speaker 7 of 10
Martina Damo, Yale University, USA
Tissue Type Determines the Outcome of Peripheral T Cell Tolerance Induction

Wednesday, January 29 | 2:30PM - 4:30PM
Workshop 2: New Approaches to Target Tissue Immunity in Auto
immunity and Cancer
Room: Pearl Street Ballroom

Speaker 8 of 10
Bernardo S. Reis, Rockefeller University, USA
Role of Intraepithelial gamma delta Lymphocytes during Colon Cancer Development and Progression

Wednesday, January 29 | 2:30PM - 4:30PM
Workshop 2: New Approaches to Target Tissue Immunity in Auto
immunity and Cancer
Room: Pearl Street Ballroom

Speaker 9 of 10
Zuri Sullivan, Yale University, USA
Gammadelta T-Cells Regulate Intestinal Epithelial Response to Nutrient Sensing

Wednesday, January 29 | 2:30PM - 4:30PM
Workshop 2: New Approaches to Target Tissue Immunity in Auto
immunity and Cancer
Room: Pearl Street Ballroom

Speaker 10 of 10
Shiqun Zhang, University of Pittsburgh, USA
MrgprD-Expressing Neurons Maintain Cutaneous Mast Cell Homeostasis

Wednesday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, January 29 | 5:00PM - 6:00PM
Microbiota and Tissue Immunity
Room: Pearl Street Ballroom

Speaker 1 of 3
* Ivaylo I. Ivanov, Columbia University, USA

Wednesday, January 29 | 5:00PM - 6:00PM
Microbiota and Tissue Immunity
Room: Pearl Street Ballroom

Speaker 2 of 3
Dan R. Littman, HHMI/New York University School of Medicine, USA
Gut Microbiota and Systemic Immunity

Wednesday, January 29 | 5:00PM - 6:00PM
Microbiota and Tissue Immunity
Room: Pearl Street Ballroom

Speaker 3 of 3
Jun R. Huh, Harvard Medical School, USA
Immune Modulatory Roles of Bile Acid Metabolites

Wednesday, January 29 | 6:00PM - 6:45PM
Closing Keynote Address
Room: Pearl Street Ballroom

Speaker 1 of 2
* Ramnik Xavier, Massachusetts General Hospital, USA

Wednesday, January 29 | 6:00PM - 6:45PM
Closing Keynote Address
Room: Pearl Street Ballroom

Speaker 2 of 2
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Innate Resident T Cells in Skin Immunity

Wednesday, January 29 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Pearl Street Ballroom


Wednesday, January 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pearl Street Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, January 29 | 8:00PM - 11:00PM
Entertainment
Room: Pearl Street Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 30 | 10:24AM - 10:24AM
Departure


*Session Chair.