Web Desc
Antibodies as Drugs: From B Cell Biology to New Treatments
Organizer(s): Paul Carter, Janine Schuurman and Karl Dane Wittrup
Date: February 02 - 06, 2020
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Sponsored by BioLegend, Inc., Compass Therapeutics, Incyte Corporation, MorphoSys AG and Surface Oncology

Supported by a grant from Genentech
Summary of Meeting:
Since the mid-1990s, antibodies have grown steadily into a clinically important pharmaceutical class with over 70 antibody-based drugs approved, predominantly in oncology, autoimmunity and inflammation. As the antibody drug field has expanded and matured in recent years, the field has moved from empirical strategies to deep knowledge-based, designer approaches for which understanding of mechanisms of action is critical; there has also been a trend toward increasingly specialized meetings with a narrow focus such as cancer immunotherapy, bispecifics or B cell biology. In contrast, we are proposing a scientifically diverse program that spans a broad range of different and cutting-edge topics relevant to antibody drug development, including antibodies for infectious disease and antibody pharmacology, topics which are often under-represented at major antibody conferences. Additionally, we have chosen a diverse collection of speakers from junior investigators to seasoned researchers from a wide range of institutions in at least eight different countries. We hope and expect that this approach will stimulate ‘cross-pollination’ between disciplines that span the gamut from basic to translational to clinical sciences with the common theme of antibody drugs for the benefit of patients.
Scholarship Deadline: October 17 2019
Discounted Abstract Deadline: October 17 2019
Abstract Deadline: November 5 2019
Discounted Registration Deadline: December 5 2019
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
BioLegend, Inc.Compass TherapeuticsGenentech, Inc.Incyte CorporationMorphoSys AGSurface Oncology
We gratefully acknowledge additional support from these exhibitors at this conference:
10x Genomics
We gratefully acknowledge additional support for this conference from:
AdipoGen Life SciencesAmerican Association for Cancer Research (AACR)American Society of Gene & Cell Therapy (ASGCT)MacroGenics, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Adimab, Inc.

Akrevia Therapeutics

Genentech, Inc.

Genmab A/S

Immatics Biotechnologies GmbH

Light Chain Bioscience

Regeneron Pharmaceuticals, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 02 | 4:00PM - 8:00PM
Arrival and Registration
Room: Cava Santa Fe


Sunday, February 02 | 6:00PM - 8:00PM
Welcome Mixer
Room: Cava Santa Fe
No registration fees are used to fund alcohol served at this function.

Monday, February 03 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado B


Monday, February 03 | 7:30AM - 8:00AM
Poster Setup
Room: Eldorado B


Monday, February 03 | 8:00AM - 7:00PM
Poster Viewing
Room: Eldorado B


Monday, February 03 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado A

Speaker 1 of 2
* Karl Dane Wittrup, Massachusetts Institute of Technology, USA

Monday, February 03 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado A

Speaker 2 of 2
Glenn Dranoff, Novartis Institutes for BioMedical Research, USA
Future Prospects for Cancer Immunotherapy

Monday, February 03 | 9:00AM - 11:15AM
Immunoglobulin Repertoires: From Basic Biology to Therapeuti
c Applications

Room: Eldorado A

Speaker 1 of 6
* Laura M. Walker, Adimab LLC, USA

Monday, February 03 | 9:00AM - 11:15AM
Immunoglobulin Repertoires: From Basic Biology to Therapeuti
c Applications

Room: Eldorado A

Speaker 2 of 6
Pierre Bruhns, Institut Pasteur, France
Deep-Mining of Antibody Repertoires for Diagnostics and Therapeutic Antibody Discovery

Monday, February 03 | 9:00AM - 11:15AM
Immunoglobulin Repertoires: From Basic Biology to Therapeuti
c Applications

Room: Eldorado A


Coffee Break

Monday, February 03 | 9:00AM - 11:15AM
Immunoglobulin Repertoires: From Basic Biology to Therapeuti
c Applications

Room: Eldorado A

Speaker 4 of 6
Ning Jenny Jiang, University of Texas at Austin, USA
Systems Immunology Based Immune Engineering

Monday, February 03 | 9:00AM - 11:15AM
Immunoglobulin Repertoires: From Basic Biology to Therapeuti
c Applications

Room: Eldorado A

Speaker 5 of 6
Sai T. Reddy, ETH Zurich, Switzerland
Antibody Discovery and Engineering by Deep Learning

Monday, February 03 | 9:00AM - 11:15AM
Immunoglobulin Repertoires: From Basic Biology to Therapeuti
c Applications

Room: Eldorado A

Speaker 6 of 6
Anupam Singhal, Berkeley Lights Inc., USA
Short Talk: Reaching the High-Hanging Fruit: Accessing Broad B Cell Diversity to Select Better Lead Candidates in Under 1 Week

Monday, February 03 | 11:15AM - 12:15PM
Lunch
Room: Eldorado B


Monday, February 03 | 12:00PM - 2:30PM
Poster Session 1
Room: Eldorado B


Monday, February 03 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Monday, February 03 | 5:00PM - 7:00PM
Biology of Antibody Generation by B Cells
Room: Eldorado A

Speaker 1 of 5
* Pierre Bruhns, Institut Pasteur, France

Monday, February 03 | 5:00PM - 7:00PM
Biology of Antibody Generation by B Cells
Room: Eldorado A

Speaker 2 of 5
Facundo D. Batista, Massachusetts Institute of Technology and Harvard University, USA
B Cell Activation: From Molecular Events to Antibody Production

Monday, February 03 | 5:00PM - 7:00PM
Biology of Antibody Generation by B Cells
Room: Eldorado A

Speaker 3 of 5
Andrew Bradbury, Specifica, USA
Drug-Like Antibodies Straight From Selections: Enhanced Affinity & Developability from Specifica’s Generation 3 Platform

Monday, February 03 | 5:00PM - 7:00PM
Biology of Antibody Generation by B Cells
Room: Eldorado A

Speaker 4 of 5
Shane Crotty, La Jolla Institute for Immunology, USA
Probing the Human Naive B Cell Repertoire, and Developing Immunization Strategies that Enhance Antibody and Germinal Center Responses via Modulation of Immunodominance

Monday, February 03 | 5:00PM - 7:00PM
Biology of Antibody Generation by B Cells
Room: Eldorado A

Speaker 5 of 5
Patrick McTamney, AstraZeneca, USA
Short Talk: Utilizing the Human Body as a Bioreactor: Direct Comparison of in vivo Expressed Biologics (IVEB) Delivery Platforms

Monday, February 03 | 7:00PM - 7:00PM
On Own for Dinner


Tuesday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado B


Tuesday, February 04 | 8:00AM - 11:00AM
Advances in Antibodies for Immuno-Oncology
Room: Eldorado A

Speaker 1 of 8
* Falk Nimmerjahn, Universitätsklinikum Erlangen, Germany

Tuesday, February 04 | 8:00AM - 11:00AM
Advances in Antibodies for Immuno-Oncology
Room: Eldorado A

Speaker 2 of 8
Teemu T. Junttila, Genentech, Inc., USA
Optimization of Preclinical Safety and Efficacy of anti-HER2/CD3 TDB

Tuesday, February 04 | 8:00AM - 11:00AM
Advances in Antibodies for Immuno-Oncology
Room: Eldorado A

Speaker 3 of 8
Esther Breij, Genmab, Netherlands
Boosting Anti-Tumor Immunity using Bispecific Antibody Molecules

Tuesday, February 04 | 8:00AM - 11:00AM
Advances in Antibodies for Immuno-Oncology
Room: Eldorado A


Coffee Break

Tuesday, February 04 | 8:00AM - 11:00AM
Advances in Antibodies for Immuno-Oncology
Room: Eldorado A

Speaker 5 of 8
Nicolas Fischer, Light Chain Bioscience / Novimmune SA, Switzerland
Harnessing Macrophage Activity via Targeted Inhibition of the CD47-SIPRa Axis

Tuesday, February 04 | 8:00AM - 11:00AM
Advances in Antibodies for Immuno-Oncology
Room: Eldorado A

Speaker 6 of 8
Jennifer E. O'Neil, Akrevia Therapeutics, USA
Development of a Highly Potent anti-CTLA-4 Antibody Active Specifically in the Tumor Microenvironment

Tuesday, February 04 | 8:00AM - 11:00AM
Advances in Antibodies for Immuno-Oncology
Room: Eldorado A

Speaker 7 of 8
Kamal Joshi, Genentech, Inc., USA
Short Talk: Probing Chain Pairing Preferences in Bispecific Antibodies to Facilitate Production in Single Host Cells

Tuesday, February 04 | 8:00AM - 11:00AM
Advances in Antibodies for Immuno-Oncology
Room: Eldorado A

Speaker 8 of 8
Susumu Uchiyama, Osaka University, Japan
Short Talk: Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of Therapeutic IgG Molecules

Tuesday, February 04 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, February 04 | 11:00AM - 1:00PM
Poster Setup
Room: Eldorado B


Tuesday, February 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Eldorado B


Tuesday, February 04 | 2:30PM - 4:30PM
Career Roundtable
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 1 of 6
Paul Carter, Genentech, Inc., USA

Tuesday, February 04 | 2:30PM - 4:30PM
Career Roundtable
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 2 of 6
Laura M. Walker, Adimab LLC, USA

Tuesday, February 04 | 2:30PM - 4:30PM
Career Roundtable
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 3 of 6
Ning Jenny Jiang, University of Texas at Austin, USA

Tuesday, February 04 | 2:30PM - 4:30PM
Career Roundtable
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 4 of 6
Ana Maria Moro, Instituto Butantan, Brazil

Tuesday, February 04 | 2:30PM - 4:30PM
Career Roundtable
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 5 of 6
Janine Schuurman, Genmab B.V., Netherlands

Tuesday, February 04 | 2:30PM - 4:30PM
Career Roundtable
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 6 of 6
Sanjay Ram, University of Massachusetts, USA

Tuesday, February 04 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Tuesday, February 04 | 5:00PM - 7:00PM
Pharmacology of Antibody Drugs
Room: Eldorado A

Speaker 1 of 6
* Tomoyuki Igawa, Chugai Pharmabody Research, Singapore

Tuesday, February 04 | 5:00PM - 7:00PM
Pharmacology of Antibody Drugs
Room: Eldorado A

Speaker 2 of 6
Amrita Kamath, Genentech, Inc., USA
PK/PD Considerations for the Development of T-cell Dependent Bispecific Antibodies

Tuesday, February 04 | 5:00PM - 7:00PM
Pharmacology of Antibody Drugs
Room: Eldorado A

Speaker 3 of 6
Dhaval K. Shah, University at Buffalo, USA
Tissue Distribution of Antibodies: Pharmacokinetics/Pharmacodynamics Perspective

Tuesday, February 04 | 5:00PM - 7:00PM
Pharmacology of Antibody Drugs
Room: Eldorado A

Speaker 4 of 6
Tim Paul Hickling, Pfizer, Inc., USA
Mechanistic, Multiscale Mathematical Model of Immunogenicity for Therapeutic Proteins

Tuesday, February 04 | 5:00PM - 7:00PM
Pharmacology of Antibody Drugs
Room: Eldorado A

Speaker 5 of 6
Rob N. de Jong, Genmab, Netherlands
Short Talk: Therapeutic IgG Antibody Combinations Acting as Bio-Logic AND Gates

Tuesday, February 04 | 5:00PM - 7:00PM
Pharmacology of Antibody Drugs
Room: Eldorado A

Speaker 6 of 6
David P. Humphreys, UCB Pharma, UK
Short Talk: On Target Hexamerisation of IgG1 Driven by a Mutant Form of IgM tail-Piece C-Terminal Fusion

Tuesday, February 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado B
No registration fees are used to fund alcohol served at this function.

Tuesday, February 04 | 7:30PM - 10:00PM
Poster Session 2
Room: Eldorado B


Wednesday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado B


Wednesday, February 05 | 8:00AM - 11:15AM
Antibody Effector Functions
Room: Eldorado A

Speaker 1 of 9
* Galit Alter, MIT and Harvard University, USA

Wednesday, February 05 | 8:00AM - 11:15AM
Antibody Effector Functions
Room: Eldorado A

Speaker 2 of 9
Piet Gros, Utrecht University, Netherlands
Molecular Mechanisms of Antibody-Mediated Complement Activation

Wednesday, February 05 | 8:00AM - 11:15AM
Antibody Effector Functions
Room: Eldorado A

Speaker 3 of 9
Leo James, MRC Laboratory of Molecular Biology, UK
Targeted Protein Depletion using Cytosolic Antibodies

Wednesday, February 05 | 8:00AM - 11:15AM
Antibody Effector Functions
Room: Eldorado A


Coffee Break

Wednesday, February 05 | 8:00AM - 11:15AM
Antibody Effector Functions
Room: Eldorado A

Speaker 5 of 9
Falk Nimmerjahn, Universitätsklinikum Erlangen, Germany
The Organ Environment Determines Antibody-Dependent Immunotherapy Responses

Wednesday, February 05 | 8:00AM - 11:15AM
Antibody Effector Functions
Room: Eldorado A

Speaker 6 of 9
Marjolein van Egmond, VU University Medical Center, Netherlands
IgA as Therapeutic Antibodies 2.0?

Wednesday, February 05 | 8:00AM - 11:15AM
Antibody Effector Functions
Room: Eldorado A

Speaker 7 of 9
Stephanie Langel, Duke University, USA
Short Talk: Engineering Dimeric IgA Antibodies for Passive Transfer into Breastmilk and Protection against Human Rotavirus in Suckling Neonates

Wednesday, February 05 | 8:00AM - 11:15AM
Antibody Effector Functions
Room: Eldorado A

Speaker 8 of 9
Irene Nailain Nkumama, Heidelberg University, Germany
Short Talk: Fc-Dependent Antibody Effector Functions Mediate Protective Immunity against Malaria

Wednesday, February 05 | 8:00AM - 11:15AM
Antibody Effector Functions
Room: Eldorado A

Speaker 9 of 9
Yuki Yamaguchi, Osaka University, Japan
Short Talk: HDX-MS Analysis of IgG-FcRIII Interaction

Wednesday, February 05 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, February 05 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Wednesday, February 05 | 5:00PM - 7:00PM
T Cell Targeting for Cancer Therapy
Room: Eldorado A

Speaker 1 of 5
* Esther Breij, Genmab, Netherlands

Wednesday, February 05 | 5:00PM - 7:00PM
T Cell Targeting for Cancer Therapy
Room: Eldorado A

Speaker 2 of 5
Thorbald van Hall, Leiden University Medical Center, Netherlands
CD3-Engagement in the Tumor Microenvironment

Wednesday, February 05 | 5:00PM - 7:00PM
T Cell Targeting for Cancer Therapy
Room: Eldorado A

Speaker 3 of 5
Tara Lynn Arvedson, Amgen Inc., USA
Targeting T Cells to Solid Tumors using BiTE® Molecules

Wednesday, February 05 | 5:00PM - 7:00PM
T Cell Targeting for Cancer Therapy
Room: Eldorado A

Speaker 4 of 5
Amir Alpert, Immatics Biotechnologies, USA
TCR-Based Cancer Immunotherapies to Novel pMHC

Wednesday, February 05 | 5:00PM - 7:00PM
T Cell Targeting for Cancer Therapy
Room: Eldorado A

Speaker 5 of 5
Ryan Molony, Novartis Institutes for Biomedical Research, USA
Short Talk: CD8+ T Cells Require CD4+ T Cell Help to Achieve Sustained in vitro Target Tumor Cell Killing Mediated by a CD3-Engaging Bispecific Antibody

Wednesday, February 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado B
No registration fees are used to fund alcohol served at this function.

Thursday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado B


Thursday, February 06 | 8:00AM - 11:00AM
Antibodies for the Treatment of Infectious Diseases
Room: Eldorado A

Speaker 1 of 7
* Sai T. Reddy, ETH Zurich, Switzerland

Thursday, February 06 | 8:00AM - 11:00AM
Antibodies for the Treatment of Infectious Diseases
Room: Eldorado A

Speaker 2 of 7
Laura M. Walker, Adimab LLC, USA
Longitudinal Dynamics of the Human B Cell Response to the Yellow Fever 17D Vaccine

Thursday, February 06 | 8:00AM - 11:00AM
Antibodies for the Treatment of Infectious Diseases
Room: Eldorado A

Speaker 3 of 7
Sanjay Ram, University of Massachusetts, USA
DNA-Encoded Anti-Lipooligosaccharide Monoclonal Antibody Engineered to Enhance Complement Activation as a Vaccination Strategy against Multidrug-Resistant Gonorrhea

Thursday, February 06 | 8:00AM - 11:00AM
Antibodies for the Treatment of Infectious Diseases
Room: Eldorado A


Coffee Break

Thursday, February 06 | 8:00AM - 11:00AM
Antibodies for the Treatment of Infectious Diseases
Room: Eldorado A

Speaker 5 of 7
Joseph R. Francica, Vaccine Research Center, National Institutes of Health, USA
A Human Monoclonal Antibody Prevents Malaria Infection by Targeting Sporozoites in the Skin and Liver

Thursday, February 06 | 8:00AM - 11:00AM
Antibodies for the Treatment of Infectious Diseases
Room: Eldorado A

Speaker 6 of 7
Galit Alter, MIT and Harvard University, USA
A Systems Fc-Engineering Approach to Define Functional Humoral Correlates of Immunity

Thursday, February 06 | 8:00AM - 11:00AM
Antibodies for the Treatment of Infectious Diseases
Room: Eldorado A

Speaker 7 of 7
Raymond A. Alvarez, Ichor Biologics, USA
Short Talk: The Development of Human Monoclonal Antibodies to Treat Andes Hantavirus Infections

Thursday, February 06 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, February 06 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Thursday, February 06 | 5:00PM - 6:45PM
Emerging Antibody Drugs for Neurodegenerative, Cardiovascula
r and Immunological Diseases

Room: Eldorado A

Speaker 1 of 4
* Marjolein van Egmond, VU University Medical Center, Netherlands

Thursday, February 06 | 5:00PM - 6:45PM
Emerging Antibody Drugs for Neurodegenerative, Cardiovascula
r and Immunological Diseases

Room: Eldorado A

Speaker 2 of 4
Tina Schwabe, Alector, USA
Immune Modulatory Antibody Drugs for Dementia

Thursday, February 06 | 5:00PM - 6:45PM
Emerging Antibody Drugs for Neurodegenerative, Cardiovascula
r and Immunological Diseases

Room: Eldorado A

Speaker 3 of 4
Tomoyuki Igawa, Chugai Pharmabody Research, Singapore
Novel Antibody Engineering to Improve Therapeutic Index of Antibody Targeting Solid Tumors

Thursday, February 06 | 5:00PM - 6:45PM
Emerging Antibody Drugs for Neurodegenerative, Cardiovascula
r and Immunological Diseases

Room: Eldorado A

Speaker 4 of 4
Jamie M. Orengo, Regeneron Pharmaceuticals Inc., USA
Novel Approaches to Treating Allergic Disorders with Monoclonal Antibodies

Thursday, February 06 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Eldorado A


Thursday, February 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado B
No registration fees are used to fund alcohol served at this function.

Thursday, February 06 | 8:00PM - 11:00PM
Entertainment
Room: Eldorado B
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Friday, February 07 | 10:24AM - 10:24AM
Departure


*Session Chair.